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You searched for: Leucojum aestivum Remove constraint Leucojum aestivum Subject Leucojum aestivum Remove constraint Subject: Leucojum aestivum Subject term Bulgaria Remove constraint Subject term: Bulgaria
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1. Alkaloid Variability in Leucojum aestivum from Wild Populations

Author:
Liliya Georgievaa; Strahil Berkov; Violeta Kondakova; Jaume Bastida; Francesc Viladomat; Atanas Atanassov; Carles Codina
Source:
Zeitschrift für Naturforschung 2014 v.62 no.9-10 pp. 627-635
ISSN:
1865-7125
Subject:
Leucojum aestivum,   etc   ; Alzheimer disease; acetylcholinesterase; bulbs; gas chromatography-mass spectrometry; lycorine; summer; Bulgaria;     Show all 8 Subjects
Abstract:
... Leucojum aestivum (summer snowflake) is a plant species used for the extraction of galanthamine, an acetylcholinesterase inhibitor for the treatment of Alzheimer’s disease. Extracts from bulbs collected from 18 Bulgarian populations and from shoot-clumps obtained in vitro from 8 different populations showed variations in their alkaloid composition. Nineteen alkaloids were detected in the studied s ...
DOI:
10.1515/znc-2007-9-1002

2. The geographic isolation of Leucojum aestivum populations leads to divergation of alkaloid biosynthesis

Author:
Strahil Berkov; Lilija Georgieva; Violeta Kondakova; Francesc Viladomat; Jaume Bastida; Atanas Atanassov; Carles Codina
Source:
Biochemical systematics and ecology 2013 v.46 pp. 152-161
ISSN:
0305-1978
Subject:
Leucojum aestivum,   etc   ; Alzheimer disease; acetylcholinesterase; biosynthesis; chemotypes; gas chromatography; lycorine; mass spectrometry; medicine; mountains; Balearic Islands; Bulgaria; Danube River;     Show all 13 Subjects
Abstract:
... Leucojum aestivum, an industrial source of the acetylcholinesterase inhibitor galanthamine, shows a great chemodiversity in its alkaloid synthesis. Samples from various geographically distinct populations from Bulgaria and the Balearic Islands were studied by GC–MS. The alkaloid pattern of the plants of L. aestivum (subsp. pulchellum) from the Balearic Islands were dominated by crinine type compou ...
DOI:
10.1016/j.bse.2012.10.002

3. Influence of plant origin on propagation capacity and alkaloid biosynthesis during long-term in vitro cultivation of Leucojum aestivum L

Author:
Bogdanova, Yuliyana; Stoeva, Tatyana; Yanev, Stanislav; Pandova, Bozhidarka; Molle, Emil; Burrus, Monique; Stanilova, Marina
Source:
In vitro cellular & developmental biology 2009 v.45 no.4 pp. 458-465
ISSN:
1054-5476
Subject:
Leucojum aestivum,   etc   ; biosynthesis; bulbs; clones; industry; lycorine; raw materials; shoots; summer; Bulgaria;     Show all 10 Subjects
Abstract:
... The investigation deals with in vitro clonal propagation of L. aestivum L. (summer snowflake), a threatened Amaryllidaceae plant species in Bulgaria used in the pharmaceutical industry as raw material for production of galanthamine-based medicines. Plants of known origin and with different alkaloid profile were taken from the living collection of the Institute of Botany, Sofia. Bulbs were used to ...
DOI:
10.1007/s11627-008-9178-2
PubMed:
32214772
PubMed Central:
PMC7089496

4. CGC-MS of alkaloids in Leucojum aestivum plants and their in vitro cultures

Author:
Berkov, S.; Pavlov, A.; Ilieva, M.; Burrus, M.; Popov, S.; Stanilova, M.
Source:
Phytochemical analysis 2005 v.16 no.2 pp. 98-103
ISSN:
0958-0344
Subject:
Leucojum aestivum,   etc   ; capillary gas chromatography; phytochemicals; chemical analysis; isomers; mass spectrometry; Liliaceae; lycorine; Bulgaria;     Show all 9 Subjects
Abstract:
... Underivatised alkaloid mixtures extracted from intact plants and in vitro cultures of Leucojum aestivum (Amaryllidaceae) were investigated by capillary GC-MS. Excellent peak resolution for the alkaloids was exhibited and isomers of galanthamine and N-formylnorgalanthamine were well separated. Fourteen alkaloids of galanthamine, lycorine and crinane types were identified, 11 in the intact plants an ...
DOI:
10.1002/pca.824
PubMed:
15881117

5. Determination of phenolic acids in Amaryllidaceae species by high performance liquid chromatography

Author:
Nikolova, M.; Gevrenova, R.
Source:
Pharmaceutical biology 2005 v.43 no.3 pp. 289-291
ISSN:
1388-0209
Subject:
Leucojum aestivum,   etc   ; Liliaceae; Galanthus elwesii; Galanthus nivalis; Pancratium maritimum; Sternbergia; medicinal plants; plant extracts; phenolic acids; chemical constituents of plants; high performance liquid chromatography; Bulgaria;     Show all 12 Subjects
DOI:
10.1080/13880200590928906

6. Characteristics of natural growing areas for Leucojum aestivum L. in Bulgaria based on chemical composition of plants

Author:
Gorinova, N.I.; Atanassov, A.L.; Stojanov, D.V.
Source:
Journal of plant nutrition 1995 v.18 no.8 pp. 1705-1710
ISSN:
0190-4167
Subject:
Leucojum aestivum,   etc   ; nitrogen content; mineral content; nutrient content; geographical variation; alkaloids; chemical constituents of plants; Bulgaria;     Show all 8 Subjects
Abstract:
... The characterization Bulgarian natural growing areas of Leucojum aestivum L. was on the basis of the chemical composition of the plants and some soil characteristics which give an opportunity to choose those conditions suitable for growing and obtaining enlargement of the source of plant material with high galanthamine content. This information should benefit the improvement of natural growing are ...
DOI:
10.1080/01904169509365015

7. Influence of chemical composition of soils on the galanthamine content in Leucojum aestivum

Author:
Gorinova, N.I.; Atanassov, A.I.; Stojanov, D.V.; Tencheva, J.
Source:
Journal of plant nutrition 1993 v.16 no.9 pp. 1631-1636
ISSN:
0190-4167
Subject:
Leucojum aestivum,   etc   ; alkaloids; soil fertility; nutrient availability; nutrients; zinc; iron; copper; nitrogen; phosphorus; potassium; magnesium; boron; molybdenum; chemical constituents of plants; Bulgaria;     Show all 16 Subjects
Abstract:
... The elemental composition of seven soils of the main geographical regions in Bulgaria for the growth of Leucojum aestivum L. was determined. It was found that a relationship exists between the galanthamine content of the plant and the chemical composition of the soil. These results indicate that galanthamine bio-synthesis could be controlled by the soil fertility level. ...
DOI:
10.1080/01904169309364638