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- Author:
- Zhang, Xiao-Wei; Yan, Xiao-Jing; Zhou, Zi-Ren; Yang, Fei-Fei; Wu, Zi-Yu; Sun, Hong-Bin; Liang, Wen-Xue; Song, Ai-Xin; Lallemand-Breitenbach, Valérie; Jeanne, Marion; Zhang, Qun-Ye; Yang, Huai-Yu; Huang, Qiu-Hua; Zhou, Guang-Biao; Tong, Jian-Hua; Zhang, Yan; Wu, Ji-Hui; Hu, Hong-Yu; de Thé, Hugues; Chen, Sai-Juan; Chen, Zhu
- Source:
- Science 2010 v.328 no.5975 pp. 240-243
- ISSN:
- 0036-8075
- Subject:
- Oriental traditional medicine; antineoplastic activity; arsenic; cysteine; drugs; leukemia; mechanism of action; oligomerization; oncogene proteins; patients; post-translational modification; retinoic acid receptors; therapeutics; zinc finger motif
- Abstract:
- ... Arsenic, an ancient drug used in traditional Chinese medicine, has attracted worldwide interest because it shows substantial anticancer activity in patients with acute promyelocytic leukemia (APL). Arsenic trioxide (As₂O₃) exerts its therapeutic effect by promoting degradation of an oncogenic protein that drives the growth of APL cells, PML-RARα (a fusion protein containing sequences from the PML ...
- DOI:
- 10.1126/science.1183424
- https://doi.org/10.1126/science.1183424
- Author:
- Li, Chien-Te; Lin, Ching-Hsiung; Kao, Te-Yu; Wu, Ming-Fang; Yeh, Chin-Shui; Yeh, Kun-Tu; Ko, Jiunn-Liang
- Source:
- Pharmaceutical biology 2010 v.48 no.11 pp. 1302-1309
- ISSN:
- 1388-0209
- Subject:
- Oriental traditional medicine; Trichosanthes kirilowii; adenocarcinoma; animal models; antineoplastic activity; apoptosis; carcinogenesis; cell cycle; cell growth; cytotoxicity; enzyme-linked immunosorbent assay; flow cytometry; humans; immunomodulation; interferon-gamma; lung neoplasms; lymphocytes; mechanism of action; medicinal plants; metastasis; neoplasm cells; telomerase; telomeres; therapeutics
- Abstract:
- ... Context: Tianhua (TH-R) is extracted from Trichosanthes kirilowii Maxim (Cucurbitaceae) containing trichosanthin, a traditional Chinese medicine, which has been locally reported to have good anticancer effects in vivo in both animal and human models. However, there have been several reports that trichosanthin has an anticancer effect involving apoptosis. Objective: To investigate other anticancer ...
- DOI:
- 10.3109/13880201003789432
- https://doi.org/10.3109/13880201003789432
- Author:
- Florian Herrmann; Marta R. Romero; Alba G. Blazquez; Dorothea Kaufmann; Mohamed L. Ashour; Stefan Kahl; Jose J.G. Marin; Thomas Efferth; Michael Wink
- Source:
- Diversity 2011 v.3 no.4 pp. 547-580
- ISSN:
- 1424-2818
- Subject:
- Alpinia galanga; Alpinia oxyphylla; Arctium lappa; Bovine viral diarrhea virus 1; Celosia argentea var. cristata; Coptis chinensis; Euodia; Flavivirus; Glycyrrhiza; Hepatitis B virus; Hepatitis C virus; Houttuynia cordata; Kadsura; Oldenlandia diffusa; Ophioglossum; Oriental traditional medicine; Panax ginseng; Panax notoginseng; Saposhnikovia divaricata; Selaginella tamariscina; Trypanosoma brucei brucei; antineoplastic activity; antiviral properties; cattle; cell lines; cell viability; cytotoxicity; herbal medicines; humans; inhibitory concentration 50; medicinal plants; models; neoplasm cells; screening; therapeutics; China; Europe
- Abstract:
- ... In an extensive screening, the antiviral, antitrypanosomal and anticancer properties of extracts from 82 plants used in traditional Chinese medicine and European phytomedicine were determined. Several promising plants that were highly effective against hepatitis B virus (HBV), bovine viral diarrhoea virus (BVDV)—a flavivirus used here as a surrogate in vitro model of hepatitis C virus, trypanosome ...
- DOI:
- 10.3390/d3040547
- https://doi.org/10.3390/d3040547
- Author:
- Hua, Zhang; Wang, Yan-Hong; Cao, Hong-Wei; Pu, Li-Jun; Cui, Yu-Dong
- Source:
- Pharmaceutical biology 2011 v.49 no.3 pp. 269-275
- ISSN:
- 1388-0209
- Subject:
- Eisenia fetida; Escherichia coli; Lumbricus rubellus; Oriental traditional medicine; Staphylococcus aureus; antibacterial properties; antineoplastic activity; dose response; earthworms; erythrocytes; gel chromatography; hemolysis; inhibitory concentration 50; ion exchange chromatography; minimum inhibitory concentration; molecular weight; polyacrylamide gel electrophoresis; sodium dodecyl sulfate; ultrafiltration
- Abstract:
- ... Context: Earthworm Eisenia foetida (Lumbricus rubellus), a traditional Chinese medicine, is used for treating many diseases, and its coelomic fluid has extensive biological functions. Objective: The hemolytic, antibacterial and antitumor activities of an earthworm protein purified from coelomic fluid were investigated in vitro. Materials and methods: We used ultrafiltration, gel chromatography, an ...
- DOI:
- 10.3109/13880209.2010.508498
- https://doi.org/10.3109/13880209.2010.508498
- Author:
- Jian-Lan Jiang; Huan Zhang; Pei-Pei Zhou; Sheng-Nan Han; Ya-Di Han; Ying-Jin Yuan
- Source:
- Analytical methods 2013 v.5 no.3 pp. 641-647
- ISSN:
- 1759-9679
- Subject:
- Curcuma longa; Oriental traditional medicine; analytical methods; antineoplastic activity; chemical composition; human cell lines; model validation; quality control; regression analysis; support vector machines; turmeric
- Abstract:
- ... Composition–activity relationship (CAR) modeling is a novel and appropriate method to evaluate the quality of traditional Chinese medicines (TCMs) for it can correlate the chemical constituents of TCMs with their bioactivity. In this paper, we studied the relationship between the antitumor activity on HeLa cells and the curcuminoids from thirty one batches of Curcuma longa L. using support vector ...
- DOI:
- 10.1039/c2ay26192h
- https://doi.org/10.1039/c2ay26192h
- Author:
- Hong Xin; Ying Kong; Yong Wang; Yingjun Zhou; Yizhun Zhu; Dapeng Li; Wenfu Tan
- Source:
- Phytomedicine 2013 v.20 pp. 640-647
- ISSN:
- 0944-7113
- Subject:
- 4',6-diamidino-2-phenylindole; Oriental traditional medicine; Vitex negundo; Western blotting; antineoplastic activity; apoptosis; breast neoplasms; cell cycle checkpoints; cyclins; cytotoxicity; flow cytometry; histones; inhibitory concentration 50; lignans; liver neoplasms; neoplasm cells; phosphorylation; staining
- Abstract:
- ... Evn-50 is a lignan compounds mixture extracted from Vitex negundo, a widely used herb in traditional Chinese medicine. This study is aimed to define the spectrum of cytotoxic activity of EVn-50, and also to investigate mechanisms underlying the anticancer actions via assessing the influence on cell cycle using EVn-50, and the lignan compound VB1 purified from EVn-50. The cytotoxic effect of EVn-50 ...
- DOI:
- 10.1016/j.phymed.2013.02.002
- https://doi.org/10.1016/j.phymed.2013.02.002
- Author:
- Huanli Xu; Jinmei Yu; Yan Sun; Xiaona Xu; Li Li; Ming Xue; Guanhua Du
- Source:
- Phytomedicine 2013 v.20 pp. 897-903
- ISSN:
- 0944-7113
- Subject:
- Oriental traditional medicine; Scutellaria barbata; adjuvants; adverse effects; antineoplastic activity; apoptosis; caspase-3; drug therapy; fluorouracil; growth retardation; high performance liquid chromatography; messenger RNA; metabolism
- Abstract:
- ... Traditional Chinese medicines have been recognized as a new source of anticancer drugs or chemotherapy adjuvant to enhance the efficacy of chemotherapy and to ameliorate the side effects. This study aimed to investigate the antitumor effects of combined Scutellaria barbata D. Don extract (SBE) and 5-FU treatment in vitro and in vivo and the potential mechanisms. SBE was prepared and analyzed by HP ...
- DOI:
- 10.1016/j.phymed.2013.03.025
- https://doi.org/10.1016/j.phymed.2013.03.025
- Author:
- Minjung Song; Hye-Jin Park
- Source:
- Journal of ethnopharmacology 2014 v.154 no.2 pp. 311-318
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Phellinus linteus; Western blotting; animal models; anti-inflammatory activity; antineoplastic activity; brown rice; colitis; colon; dextran; filtration; gamma-aminobutyric acid; inducible nitric oxide synthase; inflammation; lipopolysaccharides; macrophages; mice; mitogen-activated protein kinase; neoplasms; nitric oxide; prostaglandin synthase; prostaglandins; sodium; sulfasalazine; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... Phellinus linteus is a herb used in traditional Asian medicine to treat stomachache, inflammation, and tumors. Recent studies show that the extract of Phellinus linteus has anti-inflammatory and antitumor activities. However, Phellinus linteus extract has limitation of high cost and limited availability because of supply shortage. Here, we grew Phellinus linteus on germinated brown rice to address ...
- DOI:
- 10.1016/j.jep.2013.12.059
- https://doi.org/10.1016/j.jep.2013.12.059
- Author:
- Hong-Xiang Sun; Li-Qing Chen; Juan Zhang; Feng-Yang Chen
- Source:
- Journal of ethnopharmacology 2014 v.153 no.3 pp. 831-839
- ISSN:
- 0378-8741
- Subject:
- GATA transcription factors; Musca domestica; Oriental traditional medicine; antibodies; antineoplastic activity; antineoplastic agents; blood serum; cell-mediated immunity; coma; cytotoxic T-lymphocytes; gene expression; immunoglobulin G; immunomodulators; insects; interferon-gamma; interleukin-10; larvae; mechanism of action; messenger RNA; mice; natural killer cells; necrosis; oral administration; osteomyelitis; protein content; sarcoma; splenocytes; stomach neoplasms; transcription (genetics)
- Abstract:
- ... The larvae of Musca domestica (Diptera: Muscidae) have been used traditionally for malnutritional stagnation, decubital necrosis, osteomyelitis, ecthyma and lip scald and also to treat coma and gastric cancer in the traditional Chinese medicine. Its in vitro antitumor activity and immunomodulatory effect in naïve mice in relation to the traditional uses were also reported. However, the in vivo ant ...
- DOI:
- 10.1016/j.jep.2014.03.052
- https://doi.org/10.1016/j.jep.2014.03.052
- Author:
- Ashwini Anjana; K.F.H Nazeer Ahamed; V. Ravichandiran; M. Sumithra; Jayaraman Anbu
- Source:
- Chinese journal of natural medicines 2014 v.12 no.2 pp. 114-120
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Sargassum wightii; antineoplastic activity; antioxidant activity; body weight; cell lines; cell proliferation; flavonoids; hematologic tests; longevity; lymphoma; mice; neoplasm cells
- Abstract:
- ... Sargassum wightii Greville is a marine brown alga belonging to the Sargassaceae family which has about 200 species. The ethanolic extract of the whole dry plant powder contained numerous phytoconstituents, including flavonoids. The study was focused on the anticancer activity of Sargassum wightii in mice.The ethanolic extract of Sargassum wightii (EESW) at two dose levels was used to examine the a ...
- DOI:
- 10.1016/S1875-5364(14)60018-2
- https://doi.org/10.1016/S1875-5364(14)60018-2
- Author:
- MAO Qian; LI Yi; LI Song-Lin; YANG Jie; ZHANG Ping-Hu; WANG Qiang
- Source:
- Chinese journal of natural medicines 2014 v.12 no.1 pp. 30-37
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Panax notoginseng; adenocarcinoma; antineoplastic activity; cytotoxicity; ethanol; hepatoma; high performance liquid chromatography; human cell lines; humans; leaves; lung neoplasms; pancreatic neoplasms; porous media; saponins
- Abstract:
- ... To evaluate the chemical profiles and cytotoxic effects among the total saponin fraction (TSF), 25% ethanol fraction (25EF), 50% ethanol fraction (50EF), and 85% ethanol fraction (85EF) prepared by macroporous resin from the leaves of Panax notoginseng.The simultaneous determination of thirteen main saponins, as well as the chemical profiles of saponin fractions of different polarity, was made by ...
- DOI:
- 10.1016/S1875-5364(14)60006-6
- https://doi.org/10.1016/S1875-5364(14)60006-6
- Author:
- Sunyeong Lee; Younghyun Lee; Young Joo Choi; Kyung-Suk Han; Hai Won Chung
- Source:
- Journal of ethnopharmacology 2014 v.152 no.2 pp. 372-376
- ISSN:
- 0378-8741
- Subject:
- Bufo bufo; DNA; Oriental traditional medicine; T-lymphocytes; antineoplastic activity; apoptosis; breast neoplasms; comet assay; dose response; ethanol; flow cytometry; genotoxicity; human cell lines; lung neoplasms; micronucleus tests; neoplasm cells; propidium; staining; therapeutics; venoms; viability
- Abstract:
- ... Chan Su, an ethanolic extract from skin and parotid venom glands of the Bufo bufo gargarizans Cantor, is widely used as a traditional Chinese medicine for cancer therapy. Although the anti-cancer properties of Chan Su have been investigated, no information exists regarding whether Chan Su has genotoxic effects in cancer cells. The aim of the present study was to examine the cyto-/genotoxic effect ...
- DOI:
- 10.1016/j.jep.2014.01.023
- https://doi.org/10.1016/j.jep.2014.01.023
- Author:
- ZHAO Ren-Ping; LIN Sen-Sen; Sheng-Tao YUAN; Bo-Yang YU; Xian-Shu BAI; Li SUN; Lu-Yong ZHANG
- Source:
- Chinese journal of natural medicines 2014 v.12 no.1 pp. 24-29
- ISSN:
- 1875-5364
- Subject:
- CCR5 receptor; Ophiopogon japonicus; Oriental traditional medicine; Western blotting; adhesion; antineoplastic activity; cell proliferation; hypoxia-inducible factor 1; lungs; messenger RNA; metastasis; mice; normoxia; protein content; protein synthesis; quantitative polymerase chain reaction; saponins; tubers; vascular endothelial growth factors
- Abstract:
- ... To investigate the anticancer activity of DT-13 under normoxia and determine the underlying mechanisms of action.MDA-MB-435 cell proliferation, migration, and adhesion were performed to assess the anticancer activity of DT-13, a saponin from Ophiopogon japonicus, in vitro. In addition, the effects of DT-13 on tumor growth and metastasis in vivo were evaluated by orthotopic implantation of MDA-MB-4 ...
- DOI:
- 10.1016/S1875-5364(14)60005-4
- https://doi.org/10.1016/S1875-5364(14)60005-4
- Author:
- Yu-Xia Wang; Xiang-Xiang Gu; Di Geng; Hua-Ying Sun; Chun-Mei Wang; Gui-Xiang Jiang; Xin-Nan Hou; Chang-Hua Ma
- Source:
- Journal of ethnopharmacology 2014 v.155 no.3 pp. 1583-1588
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; albumins; alkaline phosphatase; analytical kits; antineoplastic activity; cell differentiation; cell lines; cell proliferation; clones; cytotoxicity; dose response; gamma-glutamyltransferase; hepatoma; high performance liquid chromatography; mice; mitogen-activated protein kinase; neoplasm cells; protein content; radioimmunoassays; reptiles; secretion; signal transduction; China
- Abstract:
- ... Gecko, a kind of reptile, has been widely used as a traditional Chinese medicine to treat various diseases including cancer in China for thousands of years. The aim of this study was to investigate the anti-tumor effect of AG (aqueous extracts of fresh gecko) on human hepatocellular carcinoma cell Bel-7402 in vitro and mouse H22 hepatocellular in vivo. Further to underlie the molecular mechanism o ...
- DOI:
- 10.1016/j.jep.2014.07.050
- https://doi.org/10.1016/j.jep.2014.07.050
- Author:
- Le-Le ZHANG; Li-Na MA; Dan YAN; Cong-En ZHANG; Dan GAO; Yin XIONG; Fei-Ya SHENG; Xiao-Ping DONG; Xiao-He XIAO
- Source:
- Chinese journal of natural medicines 2014 v.12 no.6 pp. 428-435
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; antineoplastic activity; berberine; cell growth; cisplatin; cytotoxicity; death; human cell lines; in vitro studies; inhibitory concentration 50; monitoring; screening
- Abstract:
- ... To investigate the cytotoxic effects of the six protoberberine alkaloids (PAs) from Rhizoma Coptidis on HepG2 cells.A systematic screening was conducted to investigate the dynamic response of HepG2 cells to the PAs using the impedance-based xCELLigence system. Cisplatin was selected as the positive control. The real time, concentration-response curves and the 50% inhibitory concentrations (IC50) w ...
- DOI:
- 10.1016/S1875-5364(14)60067-4
- https://doi.org/10.1016/S1875-5364(14)60067-4
- Author:
- Horng-Huey Ko; Yao-Chang Chiang; Ming-Horng Tsai; Chan-Jung Liang; Lee-Fen Hsu; Shu-Yu Li; Moo-Chin Wang; Feng-Lin Yen; Chiang-Wen Lee
- Source:
- Journal of ethnopharmacology 2014 v.151 no.1 pp. 386-393
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Phyla nodiflora; Western blotting; anti-inflammatory activity; antineoplastic activity; cytotoxicity; dose response; enzyme activity; enzyme-linked immunosorbent assay; flavonoids; gene expression regulation; herbal tea; hyperpigmentation; inflammation; melanin; melanogenesis; melanoma; mice; mitogen-activated protein kinase; phosphorylation; protein content; protein synthesis; transcription (genetics); transcription factors
- Abstract:
- ... In hyperpigmentation disorders marked by melanin overproduction in the skin, including melisma and freckles, melanogenesis is caused by tyrosinase overexpression. Natural medicinal resources, like Phyla nodiflora, a traditional Chinese herbal medicine, have been used for a long time to management of dermatological conditions, such as skin inflammation and melanogenesis. Eupafolin, a functional fla ...
- DOI:
- 10.1016/j.jep.2013.10.054
- https://doi.org/10.1016/j.jep.2013.10.054
- Author:
- Yu Jiang; Liqiang Gu; Ruowen Zhang; Yuanyuan Zhang; Lunhui Zhang; Ping Ju; Bingjie Ma; Kexia Zhang; Kaishun Bi; Xiaohui Chen
- Source:
- Journal of ethnopharmacology 2014 v.158 pp. 317-324
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; antineoplastic activity; biomarkers; blood chemistry; blood serum; cholic acid; hippuric acid; histopathology; ingestion; kidneys; laboratory techniques; liquid chromatography; liver; males; mass spectrometry; medicinal plants; oral administration; overdose; rats; sulfates; taurine; tissues; uric acid; urine
- Abstract:
- ... Genkwa Flos, a classical traditional Chinese medicine, is used for the definite antitumor activity and tends to be taken overdose or long term in these years. While the excessive application can result in damage to liver and kidney. In this study, the indicative roles of seven potential biomarkers were evaluated to investigate hepato-nephrotoxicity in the early stages after oral administration of ...
- DOI:
- 10.1016/j.jep.2014.10.055
- https://doi.org/10.1016/j.jep.2014.10.055
- Author:
- Yan Zhang; Rui-Fan Xie; Qun-Gen Xiao; Ran Li; Xiao-Li Shen; Xin-Gen Zhu
- Source:
- Journal of ethnopharmacology 2014 v.158 pp. 404-411
- ISSN:
- 0378-8741
- Subject:
- Oldenlandia diffusa; Oriental traditional medicine; antineoplastic activity; apoptosis; caspase-3; cell cycle checkpoints; colorimetry; dose response; enzyme activity; flow cytometry; inflammation; membrane potential; mitochondria; mitochondrial membrane; mitogen-activated protein kinase; neoplasms; protein synthesis; proteins; spectrophotometers
- Abstract:
- ... Hedyotis diffusa Willd (Rubiaceae) (HDW) has been widely applied for the treatment of tumors, inflammation and toxication in traditional Chinese medicine. The antitumor effect of HDW on glioblastoma has been rarely reported. We aim to evaluate the activity of this extract and explore the underlying mechanism in U87 human glioblastoma cell line.Cytotoxicity of HDW extract on U87 cells was measured ...
- DOI:
- 10.1016/j.jep.2014.10.017
- https://doi.org/10.1016/j.jep.2014.10.017
- Author:
- Lin-Fang HUANG; Zeng-Hui WANG; Shi-Lin CHEN
- Source:
- Chinese journal of natural medicines 2014 v.12 no.2 pp. 81-88
- ISSN:
- 1875-5364
- Subject:
- Hypericum; Oriental traditional medicine; antineoplastic activity; biosynthesis; chemists; hypericin; synthesis
- Abstract:
- ... Hypericin is one of the most important phenanthoperylene quinones extracted mainly from plants of the genus Hypericum belonging to the sections Euhypericum and Campylosporus of Keller's classification. Widespread attention to the antiviral and anti-tumor properties of hypericin has spurred investigations of the chemical synthesis and biosynthesis of this unique compound. However, the synthetic str ...
- DOI:
- 10.1016/S1875-5364(14)60014-5
- https://doi.org/10.1016/S1875-5364(14)60014-5
- Author:
- Qing ZHANG; Jing-Li LIU; Xiao-Man QI; Chun-Ting QI; Qiang YU
- Source:
- Chinese journal of natural medicines 2014 v.12 no.8 pp. 607-612
- ISSN:
- 1875-5364
- Subject:
- Caesalpinia sappan; Oriental traditional medicine; active ingredients; animal models; antineoplastic activity; cytotoxicity; ethyl acetate; flow cytometry; humans; luciferase; mitosis; neoplasm cells; neoplasms; plasmids; transcription factor NF-kappa B
- Abstract:
- ... To investigate the active constituents of Lignum Sappan (Caesalpinia sappan L.) on growth-related signaling and cell mitosis.The influence of the ethyl acetate (EtOAc) extract of Lignum Sappan and its constituents on growth-related signaling were evaluated by a luciferase assay in cells stably-transfected with NF-κB, STAT1, or STAT3 responsive luciferase reporter plasmid. The inhibitory effect on ...
- DOI:
- 10.1016/S1875-5364(14)60092-3
- https://doi.org/10.1016/S1875-5364(14)60092-3
- Author:
- Mei-Wan CHEN; Wen-Rong CHEN; Jin-Ming ZHANG; Xiao-Ying LONG; Yi-Tao WANG
- Source:
- Chinese journal of natural medicines 2014 v.12 no.2 pp. 103-107
- ISSN:
- 1875-5364
- Subject:
- Lobelia chinensis; Oriental traditional medicine; antineoplastic activity; antineoplastic agents; breathing; chemical composition; flavonoids; piperidine alkaloids; research and development
- Abstract:
- ... Research has demonstrated that many chemical constituents dominated by piperidine alkaloids and flavonoids, such as lobelanidine, lobeline, and lobelanine, have been obtained from Lobelia chinensis Lour. Experimental studies and clinical applications have also indicated that L. chinensis possesses a number of pharmacological activities (e.g., diuretic, choleretic, breathing excitement, anti-venom, ...
- DOI:
- 10.1016/S1875-5364(14)60016-9
- https://doi.org/10.1016/S1875-5364(14)60016-9
- Author:
- Shuang SONG; Ye-Wei HUANG; Yang TIAN; Xuan-Jun WANG; Jun SHENG
- Source:
- Chinese journal of natural medicines 2014 v.12 no.9 pp. 654-662
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Western blotting; antineoplastic activity; catalase; dose response; epigallocatechin gallate; high performance liquid chromatography; hydrogen peroxide; mechanism of action; mitogen-activated protein kinase; neoplasm cells; oxidation; phosphorylation; polyphenols; superoxide dismutase; tea
- Abstract:
- ... (–)-Epigallocatechin-3-gallate (EGCG), a major compound of tea polyphenols, exhibited antitumor activity in previous studies. In these studies, EGCG usually inhibits EGFR, and impairs the ERK1/2 phosphorylation in tumor cells. The aim was to clarify the mechanism of ERK1/2 activation induced by EGCG.Jurkat and 293T cells were treated with EGCG in different culture conditions. Western Blotting (WB) ...
- DOI:
- 10.1016/S1875-5364(14)60100-X
- https://doi.org/10.1016/S1875-5364(14)60100-X
- Author:
- Min-Yu LIU; Lin XIAO; Geng-Hui CHEN; Yong-Xiang WANG; Wei-Xia XIONG; Fei LI; Ying LIU; Xiao-Ling HUANG; Yi-Fang DENG; Zhen ZHANG; Hai-Yan SUN; Quan-Hai LIU; Ming YIN
- Source:
- Chinese journal of natural medicines 2014 v.12 no.10 pp. 768-776
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Xenorhabdus; allografting; animal models; antineoplastic activity; apoptosis; body weight; cell lines; cyclophosphamide; fluorouracil; granulocyte colony-stimulating factor; hepatoma; humans; inhibitory concentration 50; lung neoplasms; metabolites; mice; neoplasm cells; neutropenia; neutrophils; sarcoma
- Abstract:
- ... JS-38 (mitothiolore), a synthetic version of a metabolite isolated from Xenorhabdus sp., was evaluated for its anti-tumor and white blood cell (WBC) elevating activities.These anti-proliferative activities were assessed in vitro using a panel of ten cell lines. The anti-tumor activities were tested in vivo using B16 allograft mouse models and xenograft models of A549 human lung carcinoma and QGY h ...
- DOI:
- 10.1016/S1875-5364(14)60117-5
- https://doi.org/10.1016/S1875-5364(14)60117-5
- Author:
- Li Tao; Sheng Wang; Yang Zhao; Xiaobo Sheng; Aiyun Wang; Shizhong Zheng; Yin Lu
- Source:
- Phytomedicine 2014 v.21 pp. 1473-1482
- ISSN:
- 0944-7113
- Subject:
- Oriental traditional medicine; active sites; antineoplastic activity; benzoic acid; blood; blood circulation; caffeic acid; carcinogenesis; cell growth; cinnamic acid; danshensu; gallic acid; herbs; hydrogen bonding; medicinal plants; metastasis; neoplasm cells; neoplasms; prostaglandin synthase; rosmarinic acid; salvianolic acid; therapeutics
- Abstract:
- ... Integrated research of herbs and formulas characterized by functions of promoting blood circulation and removing blood stasis is one of the most active fields in traditional Chinese medicine. This paper strives to demonstrate the roles of a homologous series of phenolcarboxylic acids from these medicinal herbs in cancer treatment via targeting cyclooxygenase-2 (COX-2), a well-recognized mediator i ...
- DOI:
- 10.1016/j.phymed.2014.05.001
- https://doi.org/10.1016/j.phymed.2014.05.001
- Author:
- Lijuan Zhang; Changwei Wu; Tongnan Gu; Yixin Zhang; Yang Liu
- Source:
- Analytical methods 2014 v.6 no.11 pp. 3838-3841
- ISSN:
- 1759-9679
- Subject:
- Oriental traditional medicine; X-ray diffraction; anthraquinones; antineoplastic activity; arginine; cell lines; cytotoxicity; differential scanning calorimetry; drug formulations; high performance liquid chromatography; infrared spectroscopy; mass spectrometry; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; rhizomes; rhubarb; solubilization; water solubility
- Abstract:
- ... Rhein is a natural anthraquinone, which can be isolated from the rhizomes of rhubarb, a traditional Chinese medicine herb showing antitumor activity. The poor aqueous solubility of rhein hampers its broader applications. Rhein argininate was prepared as a potential cytotoxicity formulation by co-grinding together a 1 : 1 molar mixture of rhein and l-arginine for 8 hours. Characterization of rhein ...
- DOI:
- 10.1039/c4ay00163j
- https://doi.org/10.1039/c4ay00163j
26. Prescription patterns of Chinese herbal products for post-surgery colon cancer patients in Taiwan
- Author:
- Te-Hsin Chao; Pin-Kuei Fu; Chiung-Hung Chang; Shih-Ni Chang; Frank Chiahung Mao; Ching-Heng Lin
- Source:
- Journal of ethnopharmacology 2014 v.155 no.1 pp. 702-708
- ISSN:
- 0378-8741
- Subject:
- Oldenlandia diffusa; Oriental traditional medicine; Scutellaria barbata; antineoplastic activity; colorectal neoplasms; cross-sectional studies; databases; digestive system; food intake; ghrelin; health insurance; herbal medicines; ingredients; patients; secretion; surgery; Taiwan
- Abstract:
- ... Traditional Chinese medicine (TCM) is commonly provided to cancer patients, however, the patterns of prescriptions for this type of medicine in Taiwan are unclear. This study aimed to evaluate the use of traditional Chinese medicine products in colon cancer patients post-surgery in Taiwan and to research patterns of TCM.This was a cross-sectional study of newly diagnosed colon cancer patients who ...
- DOI:
- 10.1016/j.jep.2014.06.012
- https://doi.org/10.1016/j.jep.2014.06.012
- Author:
- Ting Zhao; Yun Feng; Jing Li; Riwen Mao; Ye Zou; Weiwei Feng; Daheng Zheng; Wei Wang; Yao Chen; Liuqing Yang; Xiangyang Wu
- Source:
- International journal of biological macromolecules 2014 v.65 pp. 33-40
- ISSN:
- 0141-8130
- Subject:
- Oriental traditional medicine; Schisandra chinensis; Toll-like receptor 4; antineoplastic activity; hemolysins; immunoglobulins; immunomodulation; inducible nitric oxide synthase; macrophage activation; macrophages; mechanism of action; messenger RNA; mice; neoplasms; nitric oxide; polysaccharides; spleen; thymus gland; tumor necrosis factor-alpha
- Abstract:
- ... Schisandra chinensis (Turcz.) Baill has been used in traditional Chinese medicine for centuries. Previous studies have shown that Schisandra polysaccharide (SCPP11) has robust antitumor activity in vivo. In this study, the immunomodulatory activity and mechanisms of action of SCPP11 were investigated further to reveal its mechanism of action against tumors. Results showed that SCPP11 increased the ...
- DOI:
- 10.1016/j.ijbiomac.2014.01.018
- https://doi.org/10.1016/j.ijbiomac.2014.01.018
- Author:
- Yongheng Bai; Hong Lu; Ge Zhang; Cunzao Wu; Chengcheng Lin; Yong Liang; Bicheng Chen
- Source:
- Life sciences 2014 v.105 no.1-2 pp. 22-30
- ISSN:
- 0024-3205
- Subject:
- Oriental traditional medicine; Sedum sarmentosum; antineoplastic activity; aristolochic acids; blood serum; creatinine; epithelial cells; epithelium; extracellular matrix; fibrosis; kidney diseases; rats; renal function; therapeutics; transforming growth factor beta 1
- Abstract:
- ... Sedum sarmentosum Bunge, a traditional Chinese herbal medicine, has a wide range of clinical effects, including anti-oxidation, anti-inflammation, and anti-cancer properties. In this study, we determined whether S. sarmentosum Bunge Extract (SSBE) has anti-fibrotic effects on renal tissues.We investigated the effects of SSBE on aristolochic acid (AA)-induced injury to renal tubular epithelial cell ...
- DOI:
- 10.1016/j.lfs.2014.04.013
- https://doi.org/10.1016/j.lfs.2014.04.013
- Author:
- Duyeol Kim; Yong-Hoon Lee; Sun Hee Park; Mi Ju Lee; Myoung Jun Kim; Ho-Song Jang; Jung-Min Lee; Hye-Yeong Lee; Beom Seok Han; Woo-Chan Son; Ji Hyeon Seok; Jong Kwon Lee; Jayoung Jeong; Jin Seok Kang; Jong-Koo Kang
- Source:
- Journal of ethnopharmacology 2014 v.151 pp. 1072-1078
- ISSN:
- 0378-8741
- Subject:
- Euodia; Oriental traditional medicine; alanine transaminase; antineoplastic activity; blood chemistry; blood serum; cholesterol; dietary supplements; excretion; females; glucose; hematology; histopathology; liver; males; oral administration; rats; spermatozoa; tissue weight; toxicity; triacylglycerols; urinalysis
- Abstract:
- ... Evodia, a fruit from Evodia rutaecarpa, has been used in oriental medicine, and since its various pharmaceutical actions, including anti-cancer activity, have become known, evodia has been widely used as a dietary supplement. However, information regarding its toxicity is limited.Evodia fruit from Evodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang (0, 25, 74, 222, 667, and 2000mg/kg) w ...
- DOI:
- 10.1016/j.jep.2013.12.006
- https://doi.org/10.1016/j.jep.2013.12.006
- Author:
- Li YANG; Jun TAN; Bo-Chu WANG; Lian-Cai ZHU
- Source:
- Chinese journal of natural medicines 2014 v.12 no.12 pp. 937-942
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; antineoplastic activity; antineoplastic agents; apoptosis; atomic absorption spectrometry; cytotoxicity; differential scanning calorimetry; emodin; flow cytometry; human cell lines; humans; inhibitory concentration 50; interphase; manganese; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; thermogravimetry; ultraviolet-visible spectroscopy; viability
- Abstract:
- ... To synthesize and characterize a novel metal complex of Mn (II) with emodin, and evaluate its anti-cancer activity. The elemental analyses, IR, UV-vis, atomic absorption spectroscopy, TG-DSC, ¹H NMR, and ¹³C NMR data were used to characterize the structure of the complex. The cytotoxicity of the complex against the human cancer cell lines HepG2, HeLa, MCF-7, B16, and MDA-MB-231 was tested by the M ...
- DOI:
- 10.1016/S1875-5364(14)60137-0
- https://doi.org/10.1016/S1875-5364(14)60137-0
- Author:
- Yue-Fei Wang; Ya-Nan Liu; Wen Xiong; Dong-Mei Yan; Yan Zhu; Xiu-Mei Gao; Yan-Tong Xu; Ai-Di Qi
- Source:
- Journal of ethnopharmacology 2014 v.151 no.1 pp. 609-617
- ISSN:
- 0378-8741
- Subject:
- Cullen corylifolium; Oriental traditional medicine; antibacterial properties; antineoplastic activity; asthma; biochemical pathways; biotransformation; dried fruit; formic acid; gastrointestinal system; glycosides; guidelines; intestinal microorganisms; oral administration; osteoporosis; pharmacokinetics; psoralen; quantitative analysis; rats; tandem mass spectrometry; ultra-performance liquid chromatography
- Abstract:
- ... The dried fruit of Psoralea corylifolia L. has been used to prevent and treat vitiligo, osteoporosis, arthralgia and asthma in Traditional Chinese Medicine for some 1600 years. Psoralen (P), isopsoralen (IP), psoralenoside (PO) and isopsoralenoside (IPO) are the major coumarins and coumarin-related benzofuran glycosides in Psoraleae Fructus, which have been reported to show estrogen-like activity, ...
- DOI:
- 10.1016/j.jep.2013.11.013
- https://doi.org/10.1016/j.jep.2013.11.013
- Author:
- You-Cheng Hseu; Chuan-Chen Lee; Yung-Chang Chen; K.J. Senthil Kumar; Chee-Shan Chen; Yu-Chi Huang; Li-Sung Hsu; Hui-Chi Huang; Hsin-Ling Yang
- Source:
- Journal of ethnopharmacology 2014 v.153 no.2 pp. 499-510
- ISSN:
- 0378-8741
- Subject:
- Antrodia; DNA fragmentation; Oriental traditional medicine; antineoplastic activity; antioxidants; apoptosis; caspase-3; cell cycle checkpoints; cell viability; culture media; cyclins; cytochrome c; death domain receptors; in vitro studies; leukemia; ligands; medicinal fungi; mice; mitochondria; mushrooms
- Abstract:
- ... The medicinal mushroom Antrodia salmonea has been used as a traditional Chinese medicine and has demonstrated antioxidant and anti-inflammatory effects.In the present study, we examined the anti-tumor activity of the fermented culture broth of Antrodia salmonea (AS) in vitro and in vivo and revealed its underlying molecular mechanism of action.Treatment of human promyelocytic leukemia (HL-60) cell ...
- DOI:
- 10.1016/j.jep.2014.03.012
- https://doi.org/10.1016/j.jep.2014.03.012
- Author:
- Dong-Ping YUAN; Jun LONG; Yin LU; Jie LIN; Li TONG
- Source:
- Chinese journal of natural medicines 2014 v.12 no.6 pp. 443-448
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; androgen receptors; angiogenesis; antineoplastic activity; apoptosis; cell cycle; databases; drugs; hepatoma; humans; mechanism of action; messenger RNA; screening; viability
- Abstract:
- ... Anticancer targets of cryptotanshinone were evaluated and rapidly forecasted with PharmMapper, a reverse pharmacophore-based screening platform, as well as drug target databases, including PDTD, DrugBank and TTD. The pathway analyses for the collection of anticancer targets screened were carried out based on the KEGG pathway database, followed by the forecast of potential pharmacological activitie ...
- DOI:
- 10.1016/S1875-5364(14)60069-8
- https://doi.org/10.1016/S1875-5364(14)60069-8
- Author:
- Wei-Jie Zhou; Sheng Wang; Zhuang Hu; Zhen-Yu Zhou; Cai-Juan Song
- Source:
- Biochemical and biophysical research communications 2015 v.467 pp. 562-569
- ISSN:
- 0006-291X
- Subject:
- 4',6-diamidino-2-phenylindole; Angelica sinensis; Oriental traditional medicine; adenosine monophosphate; antineoplastic activity; apoptosis; binding proteins; breast neoplasms; caspase-3; cyclic AMP; cytochrome c; cytosol; female genital diseases; flow cytometry; functional foods; humans; inflammation; membrane potential; mice; mitochondria; mitochondrial membrane; models; neoplasm cells; polysaccharides; protein synthesis; roots; signal transduction; staining
- Abstract:
- ... Angelica sinensis polysaccharide (ASP) is purified from the fresh roots of Angelica sinensis (AS). This traditional Chinese medicine has been used for thousands of years for treating gynecological diseases and used in functional foods for the prevention and treatment of various diseases, such as inflammation and cancer. The antitumor activity of ASP is related to its biological activities, because ...
- DOI:
- 10.1016/j.bbrc.2015.09.145
- https://doi.org/10.1016/j.bbrc.2015.09.145
- Author:
- Peng Wei; Chen Zhiyu; Tang Xu; Zheng Xiangwei
- Source:
- BMC complementary and alternative medicine 2015 v.15 no.1 pp. 33
- ISSN:
- 1472-6882
- Subject:
- Alocasia; Oriental traditional medicine; Western blotting; alternative medicine; antineoplastic activity; apoptosis; cancer therapy; caspases; cell cycle; cell lines; chromatin; cyclins; cytochrome c; cytotoxicity; ethyl acetate; flow cytometry; gene expression; humans; inhibitory concentration 50; neoplasm cells; petroleum; protein synthesis; stomach neoplasms
- Abstract:
- ... BACKGROUND: Alocasia cucullata (Lour.) G. Don was applied in traditional Chinese medicine for the treatment of cancer in Chinese Southwest area. Its antitumor effect was scrutinized in vitro and in vivo. And for the first time, the mechanism of extract of A. cucullata (EAC) against human gastric cancer cell was well examined. METHODS: To detect the most effective fraction, the antiproliferation ef ...
- DOI:
- 10.1186/s12906-015-0554-2
- https://doi.org/10.1186/s12906-015-0554-2
- Author:
- D. Pádua; E. Rocha; D. Gargiulo; A.A. Ramos
- Source:
- Phytochemistry letters 2015 v.14 pp. 91-98
- ISSN:
- 1874-3900
- Subject:
- Oriental traditional medicine; Phaeophyceae; administered dose; angiogenesis; antineoplastic activity; antineoplastic agents; antioxidants; bioactive compounds; breast neoplasms; cell cycle checkpoints; cell death; chemoprevention; cytotoxicity; drug resistance; drug therapy; fucoidan; macroalgae; mechanism of action; metastasis; synergism; women
- Abstract:
- ... Breast cancer is one of the most common cancers among women and its incidence tends to increase year by year. Chemotherapy is an effective treatment for many types of cancer, however its toxicity in normal cells and acquired tumor resistance to the drug used are considered as the main barriers. New strategies have been proposed to increase the success of anticancer drugs namely it combination with ...
- DOI:
- 10.1016/j.phytol.2015.09.007
- https://doi.org/10.1016/j.phytol.2015.09.007
- Author:
- T. Li; H. Pan; Y. Feng; H. Li; Y. Zhao
- Source:
- South African journal of botany 2015 v.100 pp. 87-93
- ISSN:
- 0254-6299
- Subject:
- Hedera nepalensis; Oriental traditional medicine; antineoplastic activity; antineoplastic agents; apoptosis; cell growth; chromatography; death; dose response; growth retardation; humans; lung neoplasms; perennials; saponins; spectroscopy; China
- Abstract:
- ... Lung cancer is the number one cause of death among individuals with malignant tumors in China and the world, for which there is no cure. Hedera nepalensis K. Koch is a perennial plant widely used in traditional Chinese medicine. Its anticancer activity has been speculated, but not fully explored. In this study, we used bioactivity-guided isolation approaches to isolate anticancer constituents from ...
- DOI:
- 10.1016/j.sajb.2015.05.011
- https://doi.org/10.1016/j.sajb.2015.05.011
- Author:
- Yanhua Tu; Yingru Xue; Dandan Guo; Lianna Sun; Meili Guo
- Source:
- Revista Brasileira de Farmacognosia 2015 v.25 no.5 pp. 553-566
- ISSN:
- 0102-695X
- Subject:
- Carthamus tinctorius; Oriental traditional medicine; adverse effects; anti-inflammatory activity; antineoplastic activity; brain; coronary disease; diabetes mellitus; fatty liver; florets; glycemic effect; hypersensitivity; hypertension; nephrotoxicity; orthopedics; osteoblasts; protective effect; spermatogenesis; stroke; therapeutics; toxicology; China
- Abstract:
- ... Carthami flos, the dried floret of Carthamus tinctorius L., Asteraceae (safflower), has been widely used in traditional Chinese medicine to treat a broad range of ailments, such as coronary heart disease, angina pectoris, gynecologic disease, stroke, and hypertension. However, although several studies on Carthami flos have been done consecutively, the results are usually scattered across various d ...
- DOI:
- 10.1016/j.bjp.2015.06.001
- https://doi.org/10.1016/j.bjp.2015.06.001
- Author:
- Peng QIU; Zhi-Xiang FENG; Jie-Wei TIAN; Zu-Chao LEI; Lei WANG; Zhi-Gang ZENG; Yi-Wen CHU; Yong-Qiang TIAN
- Source:
- Chinese journal of natural medicines 2015 v.13 no.12 pp. 942-953
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Streptomyces; antibiotics; antineoplastic activity; biochemical pathways; biosynthesis; endophytes; genes; medicinal plants; models; pathogens; polymerase chain reaction; prediction; ribosomal RNA; screening; secondary metabolites; sequence analysis; species diversity; China
- Abstract:
- ... The present study was designed to determine the taxonomic diversity and metabolic activity of the actinomycetes community, including 13 traditional medicinal plants collected in Sichuan province, China, using multiple approaches such as morphological and molecular identification methods, bioactivity assays, and PCR screening for genes involved in antibiotics biosynthesis. 119 endophytic actinomyce ...
- DOI:
- 10.1016/S1875-5364(15)30102-3
- https://doi.org/10.1016/S1875-5364(15)30102-3
- Author:
- Li-Na GUO; Rui ZHANG; Xue-Ying GUO; Tao CUI; Wei DONG; Jin-Hai HUO; Wei-Ming WANG
- Source:
- Chinese journal of natural medicines 2015 v.13 no.9 pp. 707-710
- ISSN:
- 1875-5364
- Subject:
- Juglans mandshurica; Oriental traditional medicine; antineoplastic activity; hulls; inhibitory concentration 50; stomach neoplasms; walnuts
- Abstract:
- ... Two new naphthalenone compounds were isolated from green walnut husks of Juglans mandshurica and their structures were identified as 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (1), 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (2). Compounds 1 and 2 were named as Juglanstetralone A (1) and Juglanstetralone B (2). Compound 1 showed more significant anti-tumor activi ...
- DOI:
- 10.1016/S1875-5364(15)30070-4
- https://doi.org/10.1016/S1875-5364(15)30070-4
- Author:
- Li ZHANG; Jian-Ping ZHOU; Jing YAO
- Source:
- Chinese journal of natural medicines 2015 v.13 no.12 pp. 915-924
- ISSN:
- 1875-5364
- Subject:
- human cell lines; freeze drying; intravenous injection; light scattering; drugs; neoplasms; antineoplastic activity; Oriental traditional medicine; models; pharmacodynamics; mice; tissues; neoplasm cells; hemolysis; paclitaxel; drug delivery systems; nanoparticles; adverse effects; apoptosis
- Abstract:
- ... The present study was designed to develop and evaluate glycyrrhetinic acid-graft-hyaluronic acid (HGA) conjugate for intravenous paclitaxel (PTX) delivery. Lyophilized PTX-loaded self-assembled HGA nanoparticles (PTX/HGAs) were prepared and characterized by dynamic light scattering measurements. Hemolysis test, intravenous irritation assessment, and in vitro and in vivo pharmacodynamic studies wer ...
- DOI:
- 10.1016/S1875-5364(15)30097-2
- https://doi.org/10.1016/S1875-5364(15)30097-2
- Author:
- Alok Ranjan; Neel M. Fofaria; Sung-Hoon Kim; Sanjay K. Srivastava
- Source:
- Chinese journal of natural medicines 2015 v.13 no.10 pp. 730-742
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; World Health Organization; antineoplastic activity; antineoplastic agents; apoptosis; bioactive compounds; cell cycle checkpoints; cell growth; cell proliferation; clinical trials; drug therapy; metastasis; mortality; neoplasms; phytopharmaceuticals; reactive oxygen species; signal transduction
- Abstract:
- ... Cancer is generally regarded as the result of abnormal growth of cells. According to World Health Organization, cancer is the leading cause of mortality worldwide. Mother nature provides a large source of bioactive compounds with excellent therapeutic efficacy. Numerous phytochemicals from nature have been investigated for anticancer properties. In this review article, we discuss several natural c ...
- DOI:
- 10.1016/S1875-5364(15)30073-X
- https://doi.org/10.1016/S1875-5364(15)30073-X
- Author:
- Zhimin Gu; Xiaohui Wang; Ruo Qi; Lijuan Wei; Yinping Huo; Yu Ma; Lei Shi; Yongjie Chang; Gongquan Li; Lixiao Zhou
- Source:
- Biochemical and biophysical research communications 2015 v.457 pp. 187-193
- ISSN:
- 0006-291X
- Subject:
- Oriental traditional medicine; antineoplastic activity; antineoplastic agents; apoptosis; cell viability; fatty-acid synthase; humans; insulin; melanoma; patients; small interfering RNA; translation (genetics)
- Abstract:
- ... Oridonin is an orally available drug isolated from Traditional Chinese Medicine. Previous studies with oridonin have demonstrated broad-spectrum anticancer activity in a variety of cancer types. However, the effect of oridonin in uveal melanoma has not been addressed. In this study, we aimed to investigate whether oridonin elicited anticancer activity and its underlying mechanism in human uveal me ...
- DOI:
- 10.1016/j.bbrc.2014.12.086
- https://doi.org/10.1016/j.bbrc.2014.12.086
- Author:
- Chenrui Li; Qiang Li; Qibing Mei; Tingli Lu
- Source:
- Life sciences 2015 v.126 pp. 57-68
- ISSN:
- 0024-3205
- Subject:
- Epimedium; Oriental traditional medicine; antineoplastic activity; bioactive compounds; bones; drugs; icariin; ingredients; medicinal plants; moieties; neuroprotective effect; osteoporosis; pharmacokinetics; therapeutics; tissue engineering
- Abstract:
- ... Herba Epimedii is an important medicinal plant which has been used in various traditional Chinese formulations for thousands of years as well as in modern proprietary traditional Chinese medicine products. It has extensive clinical indications, especially for the treatment of sexual dysfunction and osteoporosis. There have been more than 260 chemical moieties identified in the genus Epimedium most ...
- DOI:
- 10.1016/j.lfs.2015.01.006
- https://doi.org/10.1016/j.lfs.2015.01.006
- Author:
- Wenjuan Yuan; Xiaoxia Cheng; Pan Wang; Yali Jia; Quanhong Liu; Wei Tang; Xiaobing Wang
- Source:
- Journal of ethnopharmacology 2015 v.172 pp. 410-420
- ISSN:
- 0378-8741
- Subject:
- Bryopsida; NAD ADP-ribosyltransferase; Oriental traditional medicine; Polytrichum; Western blotting; antineoplastic activity; apoptosis; calcium; caspase-3; cytochrome c; cytotoxicity; deformation; ethyl acetate; flavonoids; flow cytometry; fluorescence microscopes; high performance liquid chromatography; homeostasis; leukemia; membrane potential; mitochondria; mitochondrial membrane; mononuclear leukocytes; mosses and liverworts; neoplasm cells; plasma membrane; protein synthesis; scanning electron microscopy; spectroscopy
- Abstract:
- ... Polytrichum commune L.ex Hedw (PCLH), a moss of Bryopsida, has been used as a traditional Chinese medicine and shown to possess anticancer activities. Previous studies have indicated its anti-leukemia effect but the potential mechanisms have not been fully explained.The present study aimed to further investigate the efficacy of PCLH ethyl acetate fraction (PC-EEF) and the associated mechanisms in ...
- DOI:
- 10.1016/j.jep.2015.07.002
- https://doi.org/10.1016/j.jep.2015.07.002
- Author:
- Jin-Jian LU; De-Zhao LU; Yu-Fei CHEN; Ya-Ting DONG; Jun-Ren ZHANG; Ting LI; Zheng-Hai TANG; Zhen YANG
- Source:
- Chinese journal of natural medicines 2015 v.13 no.9 pp. 673-679
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Western blotting; antineoplastic activity; cell viability; desorption; gel electrophoresis; hepatoma; herbal medicines; human cell lines; matrix-assisted laser desorption-ionization mass spectrometry; mechanism of action; neoplasm cells; proteins; proteome; proteomics; triterpenoid saponins
- Abstract:
- ... Platycodin D (PD), a triterpenoid saponin isolated from Platycodonis Radix, is a famous Chinese herbal medicine that has been shown to have anti-proliferative effects in several cancer cell lines. The aim of this study was to determine the changes in cellular proteins after the treatment of hepatocellular carcinoma HepG2 cells with PD using proteomics approaches. The cell viability was determined ...
- DOI:
- 10.1016/S1875-5364(15)30065-0
- https://doi.org/10.1016/S1875-5364(15)30065-0
- Author:
- Dong LI; Xiao-Yi SONG; Qing-Xi Yue; Ya-Jun CUI; Miao LIU; Li-Xing FENG; Wan-Ying WU; Bao-Hong JIANG; Min YANG; Xiao-Bo QU; Xuan LIU; De-An GUO
- Source:
- Chinese journal of natural medicines 2015 v.13 no.1 pp. 41-51
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Western blotting; antineoplastic activity; antineoplastic agents; apoptosis; bioinformatics; breast neoplasms; cell cycle checkpoints; cell proliferation; clinical trials; cytokines; cytoskeleton; cytotoxicity; flow cytometry; humans; keratin; mechanism of action; metabolism; neoplasm cells; proteomics; two-dimensional gel electrophoresis; vimentin; China
- Abstract:
- ... Gambogic acid (GA) is an anticancer agent in phase ‖b clinical trial in China but its mechanism of action has not been fully clarified. The present study was designed to search the possible target-related proteins of GA in cancer cells using proteomic method and establish possible network using bioinformatic analysis. Cytotoxicity and anti-migration effects of GA in MDA-MB-231 cells were checked u ...
- DOI:
- 10.1016/S1875-5364(15)60005-X
- https://doi.org/10.1016/S1875-5364(15)60005-X
- Author:
- Chun-Yan SU; Qian-Liang MING; Khalid RAHMAN; Ting HAN; Lu-Ping QIN
- Source:
- Chinese journal of natural medicines 2015 v.13 no.3 pp. 163-182
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Salvia miltiorrhiza; adverse effects; antineoplastic activity; cerebrovascular disorders; chemical composition; coronary disease; diterpenoids; drug interactions; essential oils; hydrophilicity; medicinal plants; phenolic acids; quinones
- Abstract:
- ... Salvia miltiorrhiza Bunge (SM) is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The pr ...
- DOI:
- 10.1016/S1875-5364(15)30002-9
- https://doi.org/10.1016/S1875-5364(15)30002-9
- Author:
- Jin-Mu Yi; Ok-Sun Bang; No Soo Kim
- Source:
- BMC complementary and alternative medicine 2015 v.15 no.1 pp. 42
- ISSN:
- 1472-6882
- Subject:
- Oriental traditional medicine; Western blotting; alternative medicine; angiogenesis; antineoplastic activity; cell adhesion; cell proliferation; chorioallantoic membrane; drug therapy; extracellular matrix; non-specific protein-tyrosine kinase; phosphorylation; quantitative polymerase chain reaction; viability
- Abstract:
- ... BACKGROUND: Angiogenesis is a general hallmark of cancer; therefore, the inhibition of tumor-derived angiogenesis is considered to be an attractive target in the development of anti-cancer agents. Sa-mi-yeon-geon-tang (SMYGT), a decoction that consists of four natural medicinal products, has been traditionally prescribed in Oriental medicine to treat diverse diseases, including cancer. In the pres ...
- DOI:
- 10.1186/s12906-015-0573-z
- https://doi.org/10.1186/s12906-015-0573-z
- Author:
- Qing Yang; Yalin Yin; Guojun Yu; Yanxia Jin; Xiangdong Ye; Alok Shrestha; Wei Liu; Wenhui Yu; Hui Sun
- Source:
- International journal of biological macromolecules 2015 v.80 pp. 385-391
- ISSN:
- 0141-8130
- Subject:
- Cordyceps militaris; Oriental traditional medicine; animal models; antineoplastic activity; breast neoplasms; carcinoma; chromatography; circular dichroism spectroscopy; cytotoxicity; databases; fruiting bodies; immunomodulation; interleukin-1beta; interleukin-6; lung neoplasms; macrophages; medicinal fungi; messenger RNA; metastasis; mice; neoplasm cells; transcription (genetics); tumor necrosis factor-alpha
- Abstract:
- ... Cordyceps militaris is a famous fungus used in traditional Chinese medicine for nearly one thousand years. And its fruiting body is known to possess anticancer and immunomodulatory activities. This study describes the isolation, characterization, and test of antitumor activity of a C. militaris protein, called here as “C. militaris immunoregulatory protein” (CMIP). CMIP was purified through a thre ...
- DOI:
- 10.1016/j.ijbiomac.2015.06.050
- https://doi.org/10.1016/j.ijbiomac.2015.06.050