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- Author:
- Tingting Fang; Zhiying Zhao; Feifei Yuan; Mingyan He; Jialei Sun; Mengzhou Guo; Peixin Huang; Biwei Yang; Jinglin Xia
- Source:
- Journal of ethnopharmacology 2020 v.251 pp. 112529
- ISSN:
- 0378-8741
- Subject:
- Actinidia chinensis; Oriental traditional medicine; Western blotting; antineoplastic activity; cell lines; cytotoxicity; genes; hepatoma; messenger RNA; metastasis; mitogen-activated protein kinase; patients; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; root extracts; signal transduction; transcription factors
- Abstract:
- ... Many studies have confirmed that traditional Chinese herbs exert potential anti-tumor effects. Actinidia Chinensis Planch root has been used as a traditional Chinese medicine (TCM) for thousands of years. However, the mechanism of anti-tumor effects of Actinidia Chinensis Planch root has not been clearly clarified.To explore the molecular biological mechanisms underlying the inhibitory effect of A ...
- DOI:
- 10.1016/j.jep.2019.112529
- https://doi.org/10.1016/j.jep.2019.112529
- Author:
- Tingting Fang; Yuan Fang; Xiaojing Xu; Mingyan He; Zhiying Zhao; Peixin Huang; Feifei Yuan; Mengzhou Guo; Biwei Yang; Jinglin Xia
- Source:
- Journal of ethnopharmacology 2019 v.231 pp. 474-485
- ISSN:
- 0378-8741
- Subject:
- Actinidia chinensis; Oriental traditional medicine; animal models; antineoplastic activity; apoptosis; cell proliferation; cell viability; cytotoxicity; diuresis; gene expression; gene expression regulation; genes; hemostasis; hepatoma; herbs; messenger RNA; metastasis; patients; prognosis; quantitative polymerase chain reaction
- Abstract:
- ... Numerous studies have demonstrated the potent anticancer activity of various Chinese herbs. Actinidia chinensis Planch root (acRoots), a traditional Chinese medicine, functions as an antitumor and detoxifying agent and plays a role in diuresis and hemostasis. Treatment with acRoots confers strong inhibition of tumor growth in various forms of cancer. Here, we evaluated the anticancer activity and ...
- DOI:
- 10.1016/j.jep.2018.11.014
- https://doi.org/10.1016/j.jep.2018.11.014
- Author:
- Ya-Zheng ZHAO; Yuan-Yuan ZHANG; Han HAN; Rui-Ping FAN; Yang HU; Liang ZHONG; Jun-Ping KOU; Bo-Yang YU
- Source:
- Chinese journal of natural medicines 2018 v.16 no.10 pp. 732-748
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; antineoplastic activity; apoptosis; autophagy; mechanism of action; neoplasms; signal transduction; steroid saponins
- Abstract:
- ... The steroidal saponins are one of the saponin types that exist in an unbound state and have various pharmacological activities, such as anticancer, anti-inflammatory, antiviral, antibacterial and nerves-calming properties. Cancer is a growing health problem worldwide. Significant progress has been made to understand the antitumor effects of steroidal saponins in recent years. According to reported ...
- DOI:
- 10.1016/S1875-5364(18)30113-4
- https://doi.org/10.1016/S1875-5364(18)30113-4
- Author:
- Li-Xing FENG; Peng SUN; Tian MI; Miao LIU; Wang LIU; Si YAO; Yi-Min CAO; Xiao-Lu YU; Wan-Ying WU; Bao-Hong JIANG; Min YANG; De-An GUO; Xuan LIU
- Source:
- Chinese journal of natural medicines 2016 v.14 no.11 pp. 856-864
- ISSN:
- 1875-5364
- Subject:
- Arisaema; Oriental traditional medicine; agglutinins; antineoplastic activity; apoptosis; autophagy; caspase-3; caspase-9; cell cycle checkpoints; cytotoxicity; humans; hydrophobic interaction chromatography; inflammation; interphase; lung neoplasms; medicinal plants; neoplasm cells; organelles; patients; seizures; staining
- Abstract:
- ... Arisaema heterophyllum Blume is one of the three medicinal plants known as traditional Chinese medicine Rhizoma Arisaematis (RA). RA has been popularly used to treat patients with convulsions, inflammation, and cancer for a long time. However, the underlying mechanisms for RA effects are still unclear. The present study was designed to determine the cytotoxicity of agglutinin isolated from Arisema ...
- DOI:
- 10.1016/S1875-5364(16)30102-9
- https://doi.org/10.1016/S1875-5364(16)30102-9
- Author:
- Xueli Tong; Min Li; Di Li; Chunqin Lao; Jingmian Chen; Weijie Xu; Junxi Du; Meijiao Zhang; Xiangcai Yang; Jiejing Li
- Source:
- Journal of ethnopharmacology 2021 v.280 pp. 114434
- ISSN:
- 0378-8741
- Subject:
- Aloe vera; Oriental traditional medicine; acute toxicity; adenosine triphosphate; antineoplastic activity; apoptosis; breasts; chronic toxicity; constipation; cytotoxicity; gels; high performance liquid chromatography; immune system; lung neoplasms; malic acid; metabolism; mitochondria; necrosis; neoplasm cells; oral administration; reactive oxygen species; tandem mass spectrometry; China
- Abstract:
- ... Aloe vera (L.) Burm. f. is a typical traditional Chinese medicine (TCM) collected in the Pharmacopoeia of the People's Republic of China (version 2015). It has been traditionally used for the treatment of constipation, and its potential therapeutic activities have been widely evaluated, including anti-tumor, anti-inflammatory and immune regulatory effects. The wide application of Aloe vera in food ...
- DOI:
- 10.1016/j.jep.2021.114434
- https://doi.org/10.1016/j.jep.2021.114434
- Author:
- Jin-Mu Yi; Sarah Shin; No Soo Kim; Ok-Sun Bang
- Source:
- BMC complementary and alternative medicine 2019 v.19 no.1 pp. 339
- ISSN:
- 1472-6882
- Subject:
- Forsythia suspensa; Oriental traditional medicine; adverse effects; alternative medicine; antibodies; antineoplastic activity; antineoplastic agents; colorectal neoplasms; cytotoxicity; dried fruit; drug therapy; fruits; ganglia; herbal medicines; human diseases; immunohistochemistry; liquid chromatography; males; models; neoplasm cells; nerve growth factor; neurites; neuroprotective effect; neurotoxicity; patients; peripheral nervous system diseases; quality of life; staining; viability assays
- Abstract:
- ... BACKGROUND: The dried fruits of Forsythia suspensa has generally been used to clear heat and detoxify in traditional Korean and Chinese medicine. Oxaliplatin is a first-line treatment chemotherapeutic agent for advanced colorectal cancer, but it induces peripheral neuropathy as an adverse side effect affecting the treatment regimen and the patient’s quality of life. The present study was conducted ...
- DOI:
- 10.1186/s12906-019-2761-8
- PubMed:
- 31783843
- PubMed Central:
- PMC6884752
- https://doi.org/10.1186/s12906-019-2761-8
- Author:
- Xuan Zha; Zhoumei Xu; Yuyu Liu; Liangliang Xu; Hongxin Huang; Jingjing Zhang; Liao Cui; Chenhui Zhou; Daohua Xu
- Source:
- Natural medicines 2016 v.70 no.3 pp. 634-644
- ISSN:
- 1340-3443
- Subject:
- Danio rerio; Ginkgo; Oriental traditional medicine; Selaginella tamariscina; Western blotting; alkaline phosphatase; antineoplastic activity; antioxidants; bone formation; gene expression regulation; humans; larvae; mineralization; mitogen-activated protein kinase; osteoblasts; signal transduction; stem cells; transcription factors
- Abstract:
- ... Amentoflavone is a bioflavonoid found in a variety of traditional Chinese medicines such as Gingko and Selaginella tamariscina. It has been reported that amentoflavone has anti-inflammatory, antioxidant, antiviral and anticancer effects. However, the effect of amentoflavone on osteogenic differentiation of human mesenchymal stem cells (hMSCs) has not been studied. In this study, we aim to explore ...
- DOI:
- 10.1007/s11418-016-0993-1
- https://doi.org/10.1007/s11418-016-0993-1
- Author:
- Junqian Zhang; Chunjie Li; Li Zhang; Yongqing Heng; Shiwen Wang; Yongfu Pan; Lili Cai; Yunjing Zhang; Tong Xu; Xihui Chen; Robert M Hoffman; Lijun Jia
- Source:
- Phytomedicine 2022 v.98 pp. 153933
- ISSN:
- 0944-7113
- Subject:
- Andrographis; DNA damage; Oriental traditional medicine; adenocarcinoma; andrographolide; anti-inflammatory agents; antineoplastic activity; cancer therapy; cell cycle checkpoints; cell proliferation; cell senescence; flow cytometry; humans; lung neoplasms; lungs; mice; neoplasm cells; protein content; xenotransplantation
- Abstract:
- ... Senescence leads to permanent cell-cycle arrest and is a potential target for cancer therapy. Andrographolide (AD) is a diterpene lactone isolated from Traditional Chinese Medicine (TCM) Andrographis paniculate, which has been used as an anti-inflammatory drug in clinical practice with the potential to target senescence in recalcitrant lung cancer. To determine whether AD can induce senescence in ...
- DOI:
- 10.1016/j.phymed.2022.153933
- https://doi.org/10.1016/j.phymed.2022.153933
- Author:
- Wei-Jie Zhou; Sheng Wang; Zhuang Hu; Zhen-Yu Zhou; Cai-Juan Song
- Source:
- Biochemical and biophysical research communications 2015 v.467 pp. 562-569
- ISSN:
- 0006-291X
- Subject:
- 4',6-diamidino-2-phenylindole; Angelica sinensis; Oriental traditional medicine; adenosine monophosphate; antineoplastic activity; apoptosis; binding proteins; breast neoplasms; caspase-3; cyclic AMP; cytochrome c; cytosol; female genital diseases; flow cytometry; functional foods; humans; inflammation; membrane potential; mice; mitochondria; mitochondrial membrane; models; neoplasm cells; polysaccharides; protein synthesis; roots; signal transduction; staining
- Abstract:
- ... Angelica sinensis polysaccharide (ASP) is purified from the fresh roots of Angelica sinensis (AS). This traditional Chinese medicine has been used for thousands of years for treating gynecological diseases and used in functional foods for the prevention and treatment of various diseases, such as inflammation and cancer. The antitumor activity of ASP is related to its biological activities, because ...
- DOI:
- 10.1016/j.bbrc.2015.09.145
- https://doi.org/10.1016/j.bbrc.2015.09.145
- Author:
- Dandan Zhang; Qiao Zhang; Yunliang Zheng; Jincai Lu
- Source:
- Journal of ethnopharmacology 2020 v.259 pp. 112984
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Western blotting; antineoplastic activity; apoptosis; breast neoplasms; caspase-3; cell cycle checkpoints; cytochrome c; cytosol; flow cytometry; fluorescence microscopy; human cell lines; interphase; mechanism of action; mice; mitochondria; oral administration; phosphatidylinositol 3-kinase; rhizomes; staining; toxicity; toxicity testing; triterpenoid saponins
- Abstract:
- ... The rhizome of Anemone raddeana Regel (A. raddeana) is a famous traditional Chinese medicine (TCM) recorded in Chinese Pharmacopoeia for the treatment of carbuncle and swelling. Carbuncle swollen is an explanation of tumor in the theory of TCM and softening and resolving hard mass effects are one of the important pharmacological activities of A. raddeana.Aim of the study: We investigated the poten ...
- DOI:
- 10.1016/j.jep.2020.112984
- https://doi.org/10.1016/j.jep.2020.112984
- Author:
- Yi LV; Kwok-Fai SO; Nai-Kei WONG; Jia XIAO
- Source:
- Chinese journal of natural medicines 2019 v.17 no.1 pp. 43-49
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; antineoplastic activity; apoptosis; dietary supplements; disease control; garlic; models; neoplasms; organic sulfur compounds
- Abstract:
- ... While most types of malignancies remain recalcitrant to treatment, application of natural products or their analogs in daily life has offered some hopes as an effective prophylaxis against cancer onset and progression in the past decades. Emerging evidence supports a link between garlic consumption and decreased cancer incidence. Notably, aged garlic extract (AGE) exhibits stronger anti-cancer act ...
- DOI:
- 10.1016/S1875-5364(19)30008-1
- https://doi.org/10.1016/S1875-5364(19)30008-1
- Author:
- Lei Peng; Chenxi Hu; Chaozheng Zhang; Yingying Lu; Shuli Man; Long Ma
- Source:
- Journal of ethnopharmacology 2020 v.251 pp. 112503
- ISSN:
- 0378-8741
- Subject:
- Conyza; Oriental traditional medicine; animal models; antineoplastic activity; apoptosis; blood serum; flow cytometry; genes; human cell lines; inflammation; interleukin-1beta; interleukin-2; luciferase; mice; mitogen-activated protein kinase; neoplasm cells; reactive oxygen species; reverse transcriptase polymerase chain reaction; saponins; signal transduction; transforming growth factor beta; tumor necrosis factor-alpha; uterine cervical neoplasms; China
- Abstract:
- ... Conyza blinii H.Lév. is a type of natural plant distributed in southwest of China. Its dried overground section can be used in traditional Chinese medicine (TCM) for treating infections, inflammations and occasionally cancers. CBS (Conyza blinii saponin), mainly composed of triterpenoidal saponins of Conyza blinii H.Lév. CBS is considered as the major active fraction of this species. The current i ...
- DOI:
- 10.1016/j.jep.2019.112503
- https://doi.org/10.1016/j.jep.2019.112503
- Author:
- Sharaf Shehna; S Sreelekshmi; PR Remani; G Padmaja; S Lakshmi
- Source:
- Phytomedicine plus 2022 v.2 no.1 pp. 100195
- ISSN:
- 2667-0313
- Subject:
- Curcuma zedoaria; Oriental traditional medicine; antimicrobial properties; antineoplastic activity; antioxidants; apoptosis; caspase-3; cell cycle checkpoints; cyclophosphamide; longevity; lung neoplasms; lymphoma; phytochemicals; solvents; therapeutics; toxicity
- Abstract:
- ... Curcuma zedoaria is a plant with rich source of phytochemicals extensively used in ayurvedic and Chinese medicine to treat tumors and other ailments. Henceforth, this study was undertaken to scientifically validate the different solvent fractions and isolate active fraction from the plant for the study pertaining to different biological activities including cancer. The objectives of the study incl ...
- DOI:
- 10.1016/j.phyplu.2021.100195
- https://doi.org/10.1016/j.phyplu.2021.100195
- Author:
- Chaoqun Wu; Huiqi Huang; Ho-Young Choi; Yuanren Ma; Tongxi Zhou; Yu Peng; Kejian Pang; Guangwen Shu; Xinzhou Yang
- Source:
- Journal of ethnopharmacology 2021 v.269 pp. 113700
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; antineoplastic activity; apoptosis; cell growth; chromatography; cytotoxicity; dose response; endoplasmic reticulum stress; esophageal neoplasms; flow cytometry; mitochondria; neoplasm progression
- Abstract:
- ... Corilagin (β-1-O-galloyl-3,6-(R)-hexahydroxydiphenoyl-d-glucose) is a tannin isolated from the traditional ethnopharmacological plant Phmllanthi Fructus, which is widely used in not only traditional Chinese medicine but also tropical and subtropical medicine to ameliorate various diseases. This study was designed to isolate the potential anti-esophageal cancer (EC) component corilagin from Phmllan ...
- DOI:
- 10.1016/j.jep.2020.113700
- https://doi.org/10.1016/j.jep.2020.113700
- Author:
- Liying Wang; Jinpo Gu; Mingyue Zong; Qingran Zhang; Huixiang Li; Danna Li; Xiaofeng Mou; Pan Liu; Yanan Liu; Feng Qiu; Feng Zhao
- Source:
- Journal of ethnopharmacology 2021 v.267 pp. 113490
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Physalis; acetic acid; active ingredients; anti-inflammatory activity; antineoplastic activity; calyx; dose response; edema; inducible nitric oxide synthase; inflammation; lipopolysaccharides; macrophages; mice; mitogen-activated protein kinase; necrosis; neoplasms; nitric oxide; permeability; phosphorylation; prostaglandin synthase; prostaglandins; respiratory tract diseases; signal transduction; sorbents; transcription factor NF-kappa B; China
- Abstract:
- ... Physalis Calyx seu Fructus is typically used to treat inflammatory diseases such as upper respiratory tract infection and acute tonsillitis in clinical practice of China. Physalin A, a main active ingredient of this traditional Chinese medicine (TCM), has been reported for its significant anti-tumor activity. However, most reports focused on the studies of its anti-tumor activity, the anti-inflamm ...
- DOI:
- 10.1016/j.jep.2020.113490
- https://doi.org/10.1016/j.jep.2020.113490
- Author:
- Joung-Woo Hong; Ga-Eun Yang; Yoon Bum Kim; Seok Hyun Eom; Jae-Hwan Lew; Hee Kang
- Source:
- BMC complementary and alternative medicine 2012 v.12 no.1 pp. 237
- ISSN:
- 1472-6882
- Subject:
- IKappaB kinase; Oriental traditional medicine; alternative medicine; anti-inflammatory activity; antineoplastic activity; bark; blood serum; cinnamon; fractionation; gene expression; genes; ingredients; interleukin-6; intraperitoneal injection; lipopolysaccharides; macrophages; messenger RNA; mice; mitogen-activated protein kinase; models; molecular weight; oral administration; polyphenols; tumor necrosis factor-alpha; viability
- Abstract:
- ... BACKGROUND: Cinnamon bark is one of the most popular herbal ingredients in traditional oriental medicine and possesses diverse pharmacological activities including anti-bacterial, anti-viral, and anti-cancer properties. The goal of this study is to investigate the in vivo and in vitro inhibitory effect of cinnamon water extract (CWE) on lipopolysaccharide (LPS)-induced tumor necrosis factor (TNF)- ...
- DOI:
- 10.1186/1472-6882-12-237
- PubMed:
- 23190501
- PubMed Central:
- PMC3533872
- https://doi.org/10.1186/1472-6882-12-237
- Author:
- Minjung Song; Hye-Jin Park
- Source:
- Journal of ethnopharmacology 2014 v.154 no.2 pp. 311-318
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Phellinus linteus; Western blotting; animal models; anti-inflammatory activity; antineoplastic activity; brown rice; colitis; colon; dextran; filtration; gamma-aminobutyric acid; inducible nitric oxide synthase; inflammation; lipopolysaccharides; macrophages; mice; mitogen-activated protein kinase; neoplasms; nitric oxide; prostaglandin synthase; prostaglandins; sodium; sulfasalazine; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... Phellinus linteus is a herb used in traditional Asian medicine to treat stomachache, inflammation, and tumors. Recent studies show that the extract of Phellinus linteus has anti-inflammatory and antitumor activities. However, Phellinus linteus extract has limitation of high cost and limited availability because of supply shortage. Here, we grew Phellinus linteus on germinated brown rice to address ...
- DOI:
- 10.1016/j.jep.2013.12.059
- https://doi.org/10.1016/j.jep.2013.12.059
- Author:
- Jin-Jun HOU; Yao SHEN; Zhou YANG; Lin FANG; Lu-Ying CAI; Shuai YAO; Hua-Li LONG; Wan-Ying WU; De-An GUO
- Source:
- Chinese journal of natural medicines 2017 v.15 no.10 pp. 766-774
- ISSN:
- 1875-5364
- Subject:
- Euphorbia kansui; Oriental traditional medicine; antineoplastic activity; asthma; breast neoplasms; colorectal neoplasms; diterpenoids; edema; humans; inhibitory concentration 50; melanoma; neoplasm cells; staurosporine; structure-activity relationships; triterpenoids
- Abstract:
- ... Euphorbia kansui is a commonly used traditional Chinese medicine for the treatment of edema, pleural effusion, and asthma, etc. According to the previous researches, terpenoids in E. kansui possess various biological activities, e.g., anti-virus, anti-allergy, antitumor effects. In this work, twenty five terpenoids were isolated from E. kansui, including thirteen ingenane- and eight jatrophane-typ ...
- DOI:
- 10.1016/S1875-5364(17)30108-5
- https://doi.org/10.1016/S1875-5364(17)30108-5
- Author:
- Do Luong Huynh; Neelesh Sharma; Amit Kumar Singh; Simrinder Singh Sodhi; Jiao-Jiao ZHANG; Raj Kumar Mongre; Mrinmoy Ghosh; Nameun Kim; Yang Ho Park; Dong Kee Jeong
- Source:
- Chinese journal of natural medicines 2017 v.15 no.1 pp. 15-40
- ISSN:
- 1875-5364
- Subject:
- AMP-activated protein kinase; DNA; Oriental traditional medicine; Scutellaria baicalensis; adverse effects; antineoplastic activity; antioxidants; apoptosis; drug resistance; flavonoids; metastasis; neoplasms; non-specific serine/threonine protein kinase; pharmacokinetics; researchers; signal transduction; telomerase; therapeutics
- Abstract:
- ... Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis (Huang-Qin or Chinese skullcap) and has been studied thoroughly by many researchers till date for its anti-viral, anti-oxidant, anti-cancerous and neuro-protective properties. Numerous experiments conducted in vitro and in vivo have demonstrated wogonin's excellent tumor inhibitory properties. The anti-cancer mechanism of ...
- DOI:
- 10.1016/S1875-5364(17)30005-5
- https://doi.org/10.1016/S1875-5364(17)30005-5
- Author:
- Guoqiang Jiang; Jia Liu; Baoyin Ren; Lin Zhang; Lawrence Owusu; Likun Liu; Jing Zhang; Yawei Tang; Weiling Li
- Source:
- Journal of ethnopharmacology 2017 v.205 pp. 33-40
- ISSN:
- 0378-8741
- Subject:
- DNA damage; Oriental traditional medicine; Salvia miltiorrhiza; Western blotting; antineoplastic activity; apoptosis; caspases; cell movement; cell viability; chemosensitization; cisplatin; dose response; drug therapy; flow cytometry; hypertension; immunocytochemistry; metastasis; neoplasm cells; ovarian neoplasms; proteins; roots; tissue repair
- Abstract:
- ... Cryptotanshinone, a natural compound isolated from the roots of Salvia miltiorrhiza Bge. (Danshen), is a commonly used traditional Chinese medicine to treat high blood pressure in some countries. It has been shown that Cryptotanshinone induces cancer cells apoptosis and impairs cell migration and invasion. However, the antiproliferation and chemosensitization effects of Cryptotanshinone on ovarian ...
- DOI:
- 10.1016/j.jep.2017.04.026
- https://doi.org/10.1016/j.jep.2017.04.026
- Author:
- Xiangfu Song; Ting Ren; Zhou Zheng; Tiancheng Lu; Zhicheng Wang; Fengguo Du; Haibin Tong
- Source:
- International journal of biological macromolecules 2017 v.95 pp. 357-362
- ISSN:
- 0141-8130
- Subject:
- Bupleurum; Oriental traditional medicine; agarose; antineoplastic activity; blood serum; cytotoxicity; ethanol; fractionation; immunomodulation; inducible nitric oxide synthase; macrophages; mice; neoplasm cells; nitric oxide; phosphorylation; sarcoma; secretion; signal transduction; transcription factor NF-kappa B; tumor necrosis factor-alpha
- Abstract:
- ... Bupleurum chinense is a well-known traditional Chinese medicine. Polysaccharides extracted from medical plants possess multiple healthy benefits. In the present study, an alkali-extracted polysaccharide (BCAP-1) was isolated from Bupleurum chinense, and evaluated its physicochemical features, anti-tumor activities and immunomodulatory effects. BCAP-1 was obtained by alkali-extraction, ethanol prec ...
- DOI:
- 10.1016/j.ijbiomac.2016.10.112
- https://doi.org/10.1016/j.ijbiomac.2016.10.112
- Author:
- Hong-Xiang Sun; Li-Qing Chen; Juan Zhang; Feng-Yang Chen
- Source:
- Journal of ethnopharmacology 2014 v.153 no.3 pp. 831-839
- ISSN:
- 0378-8741
- Subject:
- GATA transcription factors; Musca domestica; Oriental traditional medicine; antibodies; antineoplastic activity; antineoplastic agents; blood serum; cell-mediated immunity; coma; cytotoxic T-lymphocytes; gene expression; immunoglobulin G; immunomodulators; insects; interferon-gamma; interleukin-10; larvae; mechanism of action; messenger RNA; mice; natural killer cells; necrosis; oral administration; osteomyelitis; protein content; sarcoma; splenocytes; stomach neoplasms; transcription (genetics)
- Abstract:
- ... The larvae of Musca domestica (Diptera: Muscidae) have been used traditionally for malnutritional stagnation, decubital necrosis, osteomyelitis, ecthyma and lip scald and also to treat coma and gastric cancer in the traditional Chinese medicine. Its in vitro antitumor activity and immunomodulatory effect in naïve mice in relation to the traditional uses were also reported. However, the in vivo ant ...
- DOI:
- 10.1016/j.jep.2014.03.052
- https://doi.org/10.1016/j.jep.2014.03.052
- Author:
- Zhijun Li; Haiying Bao
- Source:
- Journal of ethnopharmacology 2022 v.285 pp. 114898
- ISSN:
- 0378-8741
- Subject:
- Inonotus hispidus; Oriental traditional medicine; alanine; antineoplastic activity; aspartic acid; biosynthesis; blood serum; corticosterone; cortisol; energy; fumarates; glutamic acid; histopathology; lysine; malates; metabolomics; models; mushrooms; neoplasms; petroleum; steroid hormones; succinic acid; tricarboxylic acid cycle; tryptophan; ultra-performance liquid chromatography; China
- Abstract:
- ... The mushroom Inonotus hispidus is traditional Chinese medicine, which has been used to treat tumor illness for many years in China. However, the potential anti-tumor mechanisms of I. hispidus remain unclear.This study aimed to reveal the anti-tumor mechanism of I. hispidus petroleum ether extract (IPE) on H22 tumor-bearing mice from the point of view of metabonomics.The model of H22 tumor-bearing ...
- DOI:
- 10.1016/j.jep.2021.114898
- https://doi.org/10.1016/j.jep.2021.114898
- Author:
- Yang Shen; Fan Yang; Haiyan Peng; Guangji Zhang; Fangfang Zhu; Haojun Xu; Le Shi
- Source:
- Journal of ethnopharmacology 2022 v.282 pp. 114601
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Western blotting; antineoplastic activity; apoptosis; blood serum; cell growth; flow cytometry; hepatoma; mice; models; protein synthesis; xenotransplantation
- Abstract:
- ... Yanggan Huayu granule (YGHY) is a formula of traditional Chinese medicine that has been widely used to treat patients with liver cancer. But its working mechanism is still poorly understood.Aim of the study: To investigate the anti-tumor effect of YGHY and its working mechanisms in hepatocellular carcinoma (HCC).H22 mouse xenograft model was used to detect the effect of YGHY on hepatocellular carc ...
- DOI:
- 10.1016/j.jep.2021.114601
- https://doi.org/10.1016/j.jep.2021.114601
- Author:
- Shanshan Li; Yi Sun; Jin Huang; Bin Wang; Yinan Gong; Yuxin Fang; Yangyang Liu; Shenjun Wang; Yi Guo; Hong Wang; Zhifang Xu; Yongming Guo
- Source:
- Journal of ethnopharmacology 2020 v.258 pp. 112797
- ISSN:
- 0378-8741
- Subject:
- Astragalus membranaceus; Oriental traditional medicine; T-lymphocytes; active ingredients; adverse effects; antineoplastic activity; apoptosis; cell lines; drug therapy; herbal medicines; immunosuppression; macrophages; metastasis; models; neoplasm cells; neoplasms; pathophysiology; patients; risk; surgery
- Abstract:
- ... With cancer deaths increasing, the initiation, pathophysiology and curative management of cancer is receiving increasing attention. Traditional therapies such as surgery and chemoradiotherapy are often accompanied by suppression of host immunity, which increase the risk of metastasis. Astragalus membranceus (AM) is commonly utilized as one herbal medicine of traditional Chinese medicines (TCMs) wi ...
- DOI:
- 10.1016/j.jep.2020.112797
- https://doi.org/10.1016/j.jep.2020.112797
- Author:
- Meixia Chen; Jinfeng Wu; Qingli Luo; Shuming Mo; Yubao Lyu; Ying Wei; Jingcheng Dong
- Source:
- Nutrients 2016 v.8 no.9 pp. -
- ISSN:
- 2072-6643
- Subject:
- Oriental traditional medicine; adjuvants; adverse effects; angiogenesis; antineoplastic activity; antineoplastic agents; apoptosis; bioactive compounds; cell cycle; drug therapy; flavonols; glycosides; herbs; human cell lines; hypertension; icariin; metastasis; mice; models; neoplasm cells; neoplasms; osteoporosis; signal transduction; China
- Abstract:
- ... Cancer is one of the leading causes of deaths worldwide. Compounds derived from traditional Chinese medicines have been an important source of anticancer drugs and adjuvant agents to potentiate the efficacy of chemotherapeutic drugs and improve the side effects of chemotherapy. Herba Epimedii is one of most popular herbs used in China traditionally for the treatment of multiple diseases, including ...
- DOI:
- 10.3390/nu8090563
- PubMed:
- 27649234
- PubMed Central:
- PMC5037548
- https://doi.org/10.3390/nu8090563
- Author:
- Rui SUN; Hong-Ming ZHANG; Bao-An CHEN
- Source:
- Chinese journal of natural medicines 2018 v.16 no.9 pp. 641-643
- ISSN:
- 1875-5364
- Subject:
- Garcinia hanburyi; Oriental traditional medicine; anthelmintics; antineoplastic activity; chemical structure; neoplasm cells; neoplasms; toxicity
- Abstract:
- ... Garcinia, a kind of dry resin secreted by Garcinia hanburyi Hook. F. G., is a traditional Chinese medicine with various biological functions such as detoxification, anti-inflammatory, and anthelmintic activities. Recent studies suggest that garcinia has potential anticancer activity. Increasing evidences indicate that the main active monomer gambogic acid isolated from garcinia can inhibit the gro ...
- DOI:
- 10.1016/S1875-5364(18)30103-1
- https://doi.org/10.1016/S1875-5364(18)30103-1
- Author:
- Anusooriya Palanirajan; Poornima Kannappan; Gopalakrishnan Velliyur Kanniappan
- Source:
- Pharmacological research 2022 v.3 pp. 100105
- ISSN:
- 2667-1425
- Subject:
- Alpinia purpurata; Oriental traditional medicine; albino; anesthesia; antineoplastic activity; antineoplastic agents; antioxidants; blood serum; carcinoma; caudal vein; cervical dislocation; chloroform; ethyl acetate; herbal medicines; histopathology; ingredients; intraperitoneal injection; intravenous injection; kidneys; leaf extracts; leaves; lipids; liver; males; nucleic acids; propylene glycol; prostate gland; prostatic neoplasms; protein content; research; seminal vesicles; testosterone; toxicity
- Abstract:
- ... Numerous Chinese herbal extracts have been proved to inhibit the development of prostate cancer. Zingiberaceae family is one type of plant used as an ingredient in traditional Chinese medicine (TCM). The genus Alpinia species of the Zingiberaceae family are well-known traditional herbal medicine for anti-inflammatory, antioxidant, antimicrobial, anti-dermatophytic, anti-nociceptive, hepatoprotecti ...
- DOI:
- 10.1016/j.prmcm.2022.100105
- https://doi.org/10.1016/j.prmcm.2022.100105
- Author:
- Ashwini Anjana; K.F.H Nazeer Ahamed; V. Ravichandiran; M. Sumithra; Jayaraman Anbu
- Source:
- Chinese journal of natural medicines 2014 v.12 no.2 pp. 114-120
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Sargassum wightii; antineoplastic activity; antioxidant activity; body weight; cell lines; cell proliferation; flavonoids; hematologic tests; longevity; lymphoma; mice; neoplasm cells
- Abstract:
- ... Sargassum wightii Greville is a marine brown alga belonging to the Sargassaceae family which has about 200 species. The ethanolic extract of the whole dry plant powder contained numerous phytoconstituents, including flavonoids. The study was focused on the anticancer activity of Sargassum wightii in mice.The ethanolic extract of Sargassum wightii (EESW) at two dose levels was used to examine the a ...
- DOI:
- 10.1016/S1875-5364(14)60018-2
- https://doi.org/10.1016/S1875-5364(14)60018-2
- Author:
- Roberta Salaroli; Giulia Andreani; Chiara Bernardini; Augusta Zannoni; Debora La Mantia; Michele Protti; Monica Forni; Laura Mercolini; Gloria Isani
- Source:
- Research in veterinary science 2022 v.152 pp. 476-484
- ISSN:
- 0034-5288
- Subject:
- Artemisia annua; Oriental traditional medicine; antineoplastic activity; artemisinin; cell cycle; culture media; cytotoxicity; dogs; dose response; drug resistance; ferroptosis; lipid peroxidation; liquid chromatography; medicinal plants; osteosarcoma; phenotype; quantitative analysis; research; tandem mass spectrometry; veterinary medicine
- Abstract:
- ... Since ancient times, Artemisia annua (A. annua) has been used as a medicinal plant in Traditional Chinese Medicine. In addition, recent studies have investigated the cytotoxic effects of A. annua extracts towards cancer cells. The leading aim of the present research is to evaluate the cytotoxic effects of an hydroalcoholic extract of A. annua on two canine osteosarcoma (OSA) cell lines, OSCA-8 and ...
- DOI:
- 10.1016/j.rvsc.2022.09.012
- https://doi.org/10.1016/j.rvsc.2022.09.012
- Author:
- Li HUANG; Zhe-Ling FENG; Yi-Tao WANG; Li-Gen LIN
- Source:
- Chinese journal of natural medicines 2017 v.15 no.12 pp. 881-888
- ISSN:
- 1875-5364
- Subject:
- Clausena; Oriental traditional medicine; adverse effects; alkaloids; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; chemical constituents of plants; coumarins; cytotoxicity; drug therapy; edible fruits; fruit products; neoplasms; vegetables
- Abstract:
- ... Pharmaceutical research has focused on the discovery and development of anticancer drugs. Clinical application of chemotherapy drugs is limited due to their severe side effects. In this regard, new naturally occurring anticancer drugs have gained increasing attention because of their potential effectiveness and safety. Fruits and vegetables are promising sources of anticancer remedy. Clausena (fam ...
- DOI:
- 10.1016/S1875-5364(18)30003-7
- https://doi.org/10.1016/S1875-5364(18)30003-7
- Author:
- Chi‐Chuan Li; Fu‐Shun Yu; Ming‐Jen Fan; Ya‐Yin Chen; Jin‐Cherng Lien; Yu‐Cheng Chou; Hsu‐Feng Lu; Nou‐Ying Tang; Shu‐Fen Peng; Wen‐Wen Huang; Jing‐Gung Chung
- Source:
- Environmental toxicology 2017 v.32 no.3 pp. 723-738
- ISSN:
- 1520-4081
- Subject:
- DNA; DNA fragmentation; Oriental traditional medicine; animal models; antineoplastic activity; antineoplastic agents; apoptosis; calcium; cantharidin; carcinoma; caspase-8; cell growth; cell viability; cyclins; cytochrome c; cytotoxicity; death domain receptors; enzyme activity; enzyme inhibitors; flow cytometry; gel electrophoresis; humans; in vivo studies; interphase; membrane potential; mice; mitochondrial membrane; skin (animal); skin neoplasms
- Abstract:
- ... Cantharidin (CTD), a potential anticancer agent of Traditional Chinese Medicine has cytotxic effects in different human cancer cell lines. The cytotoxic effects of CTD on A431 human skin cancer (epidermoid carcinoma) cells in vitro and in A431 cell xenograft mouse model were examined. In vitro, A431 human skin cell were treated with CTD for 24 and 48 h. Cell phase distribution, ROS production, Ca² ...
- DOI:
- 10.1002/tox.22273
- https://doi.org/10.1002/tox.22273
- Author:
- Haibo Wang; Lide Tao; Tengyang Ni; Hao Gu; Feng Jin; Xiaojun Dai; Jun Feng; Yanbing Ding; Weiming Xiao; Shiyu Guo; Tadashi Hisamitsu; Yayun Qian; Yanqing Liu
- Source:
- Journal of ethnopharmacology 2017 v.205 pp. 147-157
- ISSN:
- 0378-8741
- Subject:
- B-lymphocytes; Celastrus orbiculatus; Oriental traditional medicine; Western blotting; analgesics; antineoplastic activity; apoptosis; caspases; cell growth; cell viability; ethyl acetate; flow cytometry; humans; image analysis; medicinal plants; membrane potential; microstructure; mitochondria; mitochondrial membrane; neoplasm cells; phosphatidylinositol 3-kinase; proteins; rapamycin; staining; stomach neoplasms; transmission electron microscopy; China
- Abstract:
- ... The traditional Chinese medicine (TCM) herb Celastrus orbiculatus is an important folk medicinal plant in China that has been used as an anti-inflammatory, antitumor, and analgesic in various diseases. The ethyl acetate extract of C. orbiculatus (C. orbiculatus extract, COE) was reported to show significant antitumor effects. However, no study in China or abroad has reported the effect and mechani ...
- DOI:
- 10.1016/j.jep.2017.04.030
- https://doi.org/10.1016/j.jep.2017.04.030
- Author:
- Chih‐Yuan Fang; Ching‐Zong Wu; Pei‐Ni Chen; Yu‐Chao Chang; Chun‐Yi Chuang; Chih‐Ting Lai; Shun‐Fa Yang; Lo‐Lin Tsai
- Source:
- Environmental toxicology 2018 v.33 no.5 pp. 545-554
- ISSN:
- 1520-4081
- Subject:
- Oriental traditional medicine; Western blotting; antineoplastic activity; cell movement; metastasis; mitogen-activated protein kinase; protein synthesis; salvianolic acid; squamous cell carcinoma; therapeutics
- Abstract:
- ... The metastasis of oral squamous cell carcinoma (OSCC) is one of the most important causes of cancer‐related deaths. Thus, various therapeutic strategies have been developed to prevent the metastasis of OSCC. Salvianolic acid A (SAA), a traditional Chinese medicine, has antithrombosis, antiplatelet, anti‐inflammation, and antitumor activities. Here, we provide molecular evidence indicating that SAA ...
- DOI:
- 10.1002/tox.22542
- https://doi.org/10.1002/tox.22542
- Author:
- Jae Sik Yu; Hyun-Soo Roh; Seul Lee; Kiwon Jung; Kwan-Hyuck Baek; Ki Hyun Kim
- Source:
- Revista Brasileira de Farmacognosia 2017 v.27 no.3 pp. 329-333
- ISSN:
- 0102-695X
- Subject:
- Momordica cochinchinensis; Oriental traditional medicine; anti-ulcer activity; antineoplastic activity; antioxidants; cell proliferation; edible fruits; endothelial cells; ethanol; humans; lung neoplasms; neoplasm cells; saponins; secondary metabolites; seeds; triterpenoids
- Abstract:
- ... Gac, Momordica cochinchinensis (Lour.) Spreng., Cucurbitaceae, is an indigenous South Asian edible fruit and has been used therapeutically in Traditional Chinese Medicine. Previous studies have shown that M. cochinchinensis seed (Momordicae Semen) has various pharmaceutical properties such as antioxidant and anti-ulcer effects as well as contains secondary metabolites with potential anticancer act ...
- DOI:
- 10.1016/j.bjp.2017.02.002
- https://doi.org/10.1016/j.bjp.2017.02.002
- Author:
- Wei GAO; Yi WANG; Ru WANG; Yi-Hai WANG; Jing-Wen XU; Xiang-Jiu HE
- Source:
- Chinese journal of natural medicines 2022 v.20 no.7 pp. 541-550
- ISSN:
- 1875-5364
- Subject:
- Alocasia macrorrhizos; Oriental traditional medicine; antineoplastic activity; apoptosis; neoplasms; phytochemicals; piperidines; rhizomes; spectroscopy; toxicity testing; wild plants
- Abstract:
- ... The rhizome of giant taro (Alocasia macrorrhiza (L.) Schott), which is a highly adaptable wild plant, is a traditional Chinese herbal medicine. In the current study, the antiproliferative constituents of giant taro were investigated and six new (1−6) and four known piperidine alkaloids (7−10) were isolated from its rhizomes. Their chemical structures and absolute configurations were elucidated usi ...
- DOI:
- 10.1016/S1875-5364(22)60165-1
- https://doi.org/10.1016/S1875-5364(22)60165-1
- Author:
- Shuai HUANG; Shuang-Mei ZHAO; Lian-Hai SHAN; Xian-Li ZHOU
- Source:
- Chinese journal of natural medicines 2020 v.18 no.2 pp. 81-89
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; antineoplastic activity; apoptosis; autophagy; caspase-9; colorectal neoplasms; human diseases; mitogen-activated protein kinase; neoplasm cells; proteins; pyrrolizidine alkaloids; signal transduction
- Abstract:
- ... Nervosine VII is one of the known saturated pyrrolizidine alkaloids isolated from the plant of Liparis nervosa. This is first study to investigate the antitumor activity of nervosine VII in vitro, and the results indicated that nervosine VII induced autophagy and apoptosis in HCT116 human colorectal cancer cells. Mechanistic studies showed that nervosine VII-induced apoptosis was associated with t ...
- DOI:
- 10.1016/S1875-5364(20)30009-1
- https://doi.org/10.1016/S1875-5364(20)30009-1
- Author:
- Peng Wei; Chen Zhiyu; Tang Xu; Zheng Xiangwei
- Source:
- BMC complementary and alternative medicine 2015 v.15 no.1 pp. 33
- ISSN:
- 1472-6882
- Subject:
- Alocasia; Oriental traditional medicine; Western blotting; alternative medicine; antineoplastic activity; apoptosis; cancer therapy; caspases; cell cycle; cell lines; chromatin; cyclins; cytochrome c; cytotoxicity; ethyl acetate; flow cytometry; gene expression; humans; inhibitory concentration 50; neoplasm cells; petroleum; protein synthesis; stomach neoplasms
- Abstract:
- ... BACKGROUND: Alocasia cucullata (Lour.) G. Don was applied in traditional Chinese medicine for the treatment of cancer in Chinese Southwest area. Its antitumor effect was scrutinized in vitro and in vivo. And for the first time, the mechanism of extract of A. cucullata (EAC) against human gastric cancer cell was well examined. METHODS: To detect the most effective fraction, the antiproliferation ef ...
- DOI:
- 10.1186/s12906-015-0554-2
- https://doi.org/10.1186/s12906-015-0554-2
- Author:
- Ying Liu; Wei Zhang; Xiao-Jie Wang; Shi Liu
- Source:
- BMC complementary and alternative medicine 2014 v.14 no.1 pp. 228
- ISSN:
- 1472-6882
- Subject:
- Coix; Oriental traditional medicine; Western blotting; alternative medicine; antineoplastic activity; apoptosis; cell viability; genes; humans; ingredients; mice; neoplasm cells; pancreatic neoplasms; proteins; reverse transcriptase polymerase chain reaction; seed oils; signal transduction; China
- Abstract:
- ... BACKGROUND: Kanglaite® injection (KLT), with a main ingredient of Coix seed oil (a traditional Chinese medicine), has been widely used for cancer treatment in China. KLT has an inhibitory effect on many kinds of tumors and PI3K/Akt/mTOR signaling promotes cell survival, proliferation, and progression in cancer cells. Therefore, targeting this pathway may lead to the development of novel therapeuti ...
- DOI:
- 10.1186/1472-6882-14-228
- PubMed:
- 25005526
- PubMed Central:
- PMC4105135
- https://doi.org/10.1186/1472-6882-14-228
- Author:
- Chunyu Shi; Qinhai Ma; Mengyue Ren; Dedong Liang; Qingtian Yu; Jiabo Luo
- Source:
- Journal of ethnopharmacology 2017 v.209 pp. 24-31
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Western blotting; Wolfiporia cocos; antineoplastic activity; apoptosis; caspase-3; caspase-9; fungi; immunohistochemistry; liver; mice; oral administration; polysaccharides; sarcoma; spleen; staining; thymus gland; tissues
- Abstract:
- ... The liquid oral formulation of Poria cocos polysaccharides is composed of polysaccharides of Lentinusedodes, Ganodermalucidum and Poria cocos(1:1:2), which are all fungi used in traditional Chinese medicine. Polysaccharides extracted from these fungi have been reported to exhibit an antitumor effect by modulating the immune system.The present study aimed to clarify the antitumor mechanism of an or ...
- DOI:
- 10.1016/j.jep.2017.07.003
- https://doi.org/10.1016/j.jep.2017.07.003
- Author:
- Dony Mathew; Wei-Li Hsu
- Source:
- Journal of functional foods 2018 v.40 pp. 692-699
- ISSN:
- 1756-4646
- Subject:
- Oriental traditional medicine; adverse effects; antineoplastic activity; antioxidants; antiviral properties; curcumin; drugs; humans; polyphenols; signal transduction; transcription factor NF-kappa B; turmeric; virus replication; viruses
- Abstract:
- ... The use of synthetic drugs has increased over the recent years, but plant-based drugs are more suitable in terms of least side effects. Since ancient times mankind has been dependent on plants for the treatment of various ailments, among them widely used is curcumin, the principal polyphenol extracted from turmeric. Their medicinal and useful properties are mentioned in Indian Veda’s and Chinese m ...
- DOI:
- 10.1016/j.jff.2017.12.017
- https://doi.org/10.1016/j.jff.2017.12.017
- Author:
- Jumah Masoud Mohammad SALMANI; Xiao-Ping ZHANG; Joe Antony JACOB; Bao-An CHEN
- Source:
- Chinese journal of natural medicines 2017 v.15 no.5 pp. 321-329
- ISSN:
- 1875-5364
- Subject:
- DNA damage; Oriental traditional medicine; antineoplastic activity; antioxidants; apigenin; apoptosis; autophagy; fruit products; mechanism of action; models; natural resources; neoplasms; risk; vegetables
- Abstract:
- ... Cancer is a major health concern and leading burden on economy worldwide. An increasing effort is devoted to isolation and development of plant-derived dietary components as effective chemo-preventive products. Phytochemical compounds from natural resources such as fruits and vegetables are responsible for decreasing the risk of certain cancers among the consuming populations. Apigenin, a flavonoi ...
- DOI:
- 10.1016/S1875-5364(17)30052-3
- https://doi.org/10.1016/S1875-5364(17)30052-3
- Author:
- Zhang, Xiao-Wei; Yan, Xiao-Jing; Zhou, Zi-Ren; Yang, Fei-Fei; Wu, Zi-Yu; Sun, Hong-Bin; Liang, Wen-Xue; Song, Ai-Xin; Lallemand-Breitenbach, Valérie; Jeanne, Marion; Zhang, Qun-Ye; Yang, Huai-Yu; Huang, Qiu-Hua; Zhou, Guang-Biao; Tong, Jian-Hua; Zhang, Yan; Wu, Ji-Hui; Hu, Hong-Yu; de Thé, Hugues; Chen, Sai-Juan; Chen, Zhu
- Source:
- Science 2010 v.328 no.5975 pp. 240-243
- ISSN:
- 0036-8075
- Subject:
- Oriental traditional medicine; antineoplastic activity; arsenic; cysteine; drugs; leukemia; mechanism of action; oligomerization; oncogene proteins; patients; post-translational modification; retinoic acid receptors; therapeutics; zinc finger motif
- Abstract:
- ... Arsenic, an ancient drug used in traditional Chinese medicine, has attracted worldwide interest because it shows substantial anticancer activity in patients with acute promyelocytic leukemia (APL). Arsenic trioxide (As₂O₃) exerts its therapeutic effect by promoting degradation of an oncogenic protein that drives the growth of APL cells, PML-RARα (a fusion protein containing sequences from the PML ...
- DOI:
- 10.1126/science.1183424
- https://doi.org/10.1126/science.1183424
- Author:
- Kuilong Wang; Wei Huang; Xianan Sang; Xin Wu; Qiyuan Shan; Dongxin Tang; Xiaofen Xu; Gang Cao
- Source:
- Phytomedicine 2020 v.68 pp. 153191
- ISSN:
- 0944-7113
- Subject:
- Oriental traditional medicine; antineoplastic activity; apoptosis; cell proliferation; colorectal neoplasms; glucose; glycolysis; in vivo studies; models; neoplasm cells; neoplasm progression; phosphorylation; proteins; reactive oxygen species; signal transduction; stem cells; therapeutics; tissues
- Abstract:
- ... Atractylenolide I (ATL-1) is a natural herbal compound used in traditional Chinese medicine that has exhibited anti-cancer properties. The anti-tumorigenic activity of ATL-1 against colorectal cancer (CRC) and the underlying signaling pathways involved in its mechanisms are examined here.ATL-1 exerts therapeutic effect against CRC by disrupting glucose metabolism and cancer stem cell maintenance v ...
- DOI:
- 10.1016/j.phymed.2020.153191
- https://doi.org/10.1016/j.phymed.2020.153191
- Author:
- Naveenkumar Chandrashekar; Anandakumar Pandi
- Source:
- Journal of food biochemistry 2022 v.46 no.9 pp. e14230
- ISSN:
- 0145-8884
- Subject:
- Oriental traditional medicine; Scutellaria baicalensis; antineoplastic activity; antineoplastic agents; antioxidants; apoptosis; autophagy; cell proliferation; flavonoids; herbal tea; human health; ingredients; lung neoplasms; lungs; mechanism of action; metastasis; mortality
- Abstract:
- ... Plant‐derived flavonoids are reported to function as potential anti‐cancer agents against different types of cancer. Baicalein (BE) is an important flavonoid found in the roots of Scutellaria baicalensis that is popularly used in Chinese medicine as an ingredient in herbal tea preparations to promote wellness. BE has been studied for its several biological effects including antioxidant, anti‐infla ...
- DOI:
- 10.1111/jfbc.14230
- https://doi.org/10.1111/jfbc.14230
- Author:
- Hae Seong Song; Sunphil Jang; Se Chan Kang
- Source:
- Phytomedicine 2018 v.40 pp. 37-47
- ISSN:
- 0944-7113
- Subject:
- Cullen corylifolium; Oriental traditional medicine; Western blotting; anthelmintics; antineoplastic activity; apoptosis; autophagy; caspase-3; cell cycle checkpoints; genes; human cell lines; osteoclasts; phosphorylation; propidium; psoralen; regulatory proteins; staining
- Abstract:
- ... Cullen corylifolium is a plant widely used in traditional Chinese medicine for its stomachic, anthelmintic, and diuretic properties. Bavachalcone, which is known as a component of C. corylifolium has been reported to inhibit osteoclast differentiation. However, the anticancer efficacy and mechanism of C. corylifolium and bavachalcone have not been studied.Our aim is to determine whether C. corylif ...
- DOI:
- 10.1016/j.phymed.2017.12.030
- https://doi.org/10.1016/j.phymed.2017.12.030
- Author:
- Fa Jin; Tao Xie; Xiaoguang Huang; Xinde Zhao
- Source:
- Pharmaceutical biology 2018 v.56 no.1 pp. 665-671
- ISSN:
- 1744-5116
- Subject:
- Oriental traditional medicine; angiogenesis; antineoplastic activity; berberine; carboxymethylcellulose; cell movement; cell viability; gene expression; glioblastoma; hemoglobin; human cell lines; human diseases; inhibitory concentration 50; messenger RNA; mice; mitogen-activated protein kinase; models; neoplasm cells; phosphorylation; survival rate; therapeutics; vascular endothelial growth factor receptor-2
- Abstract:
- ... Context: Berberine is used in traditional Chinese medicine for thousands of years with recent reports of its anticancer activity. Objective: To test antiangiogenic effects of berberine on human glioblastoma and clarify involvement of the VEGFR2/ERK pathway. Materials and methods: Cell viability, proliferation and migration assays were performed to determine in vitro antiangiogenic effects of berbe ...
- DOI:
- 10.1080/13880209.2018.1548627
- PubMed:
- 31070539
- PubMed Central:
- PMC6319470
- https://doi.org/10.1080/13880209.2018.1548627
- Author:
- Weina Ma; Man Zhu; Dongdong Zhang; Liu Yang; Tianfeng Yang; Xin Li; Yanmin Zhang
- Source:
- Phytomedicine 2017 v.25 pp. 45-51
- ISSN:
- 0944-7113
- Subject:
- Coptis chinensis; Oriental traditional medicine; antineoplastic activity; berberine; binding proteins; breast neoplasms; cell growth; cell membranes; cell movement; cell proliferation; chromatography; phosphorylation; vascular endothelial growth factor receptor-2
- Abstract:
- ... Berberine, a plant-derived compound isolated from Coptis chinensis used in traditional Chinese medicine, has been shown to possess anti-cancer properties. However, no study has shown that berberine could target ephrin-B2, which plays a critical role in cell proliferation and migration.The aim of this study is to investigate the effect of berberine on cancer cell growth and migration, through the r ...
- DOI:
- 10.1016/j.phymed.2016.12.013
- https://doi.org/10.1016/j.phymed.2016.12.013
- Author:
- D. Pádua; E. Rocha; D. Gargiulo; A.A. Ramos
- Source:
- Phytochemistry letters 2015 v.14 pp. 91-98
- ISSN:
- 1874-3900
- Subject:
- Oriental traditional medicine; Phaeophyceae; administered dose; angiogenesis; antineoplastic activity; antineoplastic agents; antioxidants; bioactive compounds; breast neoplasms; cell cycle checkpoints; cell death; chemoprevention; cytotoxicity; drug resistance; drug therapy; fucoidan; macroalgae; mechanism of action; metastasis; synergism; women
- Abstract:
- ... Breast cancer is one of the most common cancers among women and its incidence tends to increase year by year. Chemotherapy is an effective treatment for many types of cancer, however its toxicity in normal cells and acquired tumor resistance to the drug used are considered as the main barriers. New strategies have been proposed to increase the success of anticancer drugs namely it combination with ...
- DOI:
- 10.1016/j.phytol.2015.09.007
- https://doi.org/10.1016/j.phytol.2015.09.007
- Author:
- T. Li; H. Pan; Y. Feng; H. Li; Y. Zhao
- Source:
- South African journal of botany 2015 v.100 pp. 87-93
- ISSN:
- 0254-6299
- Subject:
- Hedera nepalensis; Oriental traditional medicine; antineoplastic activity; antineoplastic agents; apoptosis; cell growth; chromatography; death; dose response; growth retardation; humans; lung neoplasms; perennials; saponins; spectroscopy; China
- Abstract:
- ... Lung cancer is the number one cause of death among individuals with malignant tumors in China and the world, for which there is no cure. Hedera nepalensis K. Koch is a perennial plant widely used in traditional Chinese medicine. Its anticancer activity has been speculated, but not fully explored. In this study, we used bioactivity-guided isolation approaches to isolate anticancer constituents from ...
- DOI:
- 10.1016/j.sajb.2015.05.011
- https://doi.org/10.1016/j.sajb.2015.05.011