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- Author:
- Jia Xiong Ming; Zhao Cong Wang; Yi Huang; Hifumi Ohishi; Rong Ji Wu; Yan Shao; Hui Wang; Ming Yang Qin; Ze Liang Wu; Yi Yong Li; Shun Chang Zhou; Hui Chen; Hui Liu; Rong Xu
- Source:
- Journal of ethnopharmacology 2021 v.265 pp. 113302
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; RNA interference; Saccharina japonica; Western blotting; antineoplastic activity; cadherins; cell lines; cell proliferation; cell viability; drugs; fibronectins; fluorescent antibody technique; gene expression; human diseases; immunohistochemistry; lung neoplasms; lungs; metastasis; models; neoplasm cells; phenotype; phosphatidylinositol 3-kinase; staining; tissue repair; transcription factor NF-kappa B; xenotransplantation
- Abstract:
- ... Laminaria japonica, a brown seaweed, has been used in Traditional Chinese Medicine (TCM) to treat a variety of diseases including lung cancer.To demonstrate the effects of Fucoxanthin (FX), a major active component extracted from Laminaria japonica on metastasis and Gefitinib (Gef) sensitivity in human lung cancer cells both in vitro and in vivo.Invasion and migration of lung cancer cells were det ...
- DOI:
- 10.1016/j.jep.2020.113302
- https://doi.org/10.1016/j.jep.2020.113302
- Author:
- Tingting Fang; Zhiying Zhao; Feifei Yuan; Mingyan He; Jialei Sun; Mengzhou Guo; Peixin Huang; Biwei Yang; Jinglin Xia
- Source:
- Journal of ethnopharmacology 2020 v.251 pp. 112529
- ISSN:
- 0378-8741
- Subject:
- Actinidia chinensis; Oriental traditional medicine; Western blotting; antineoplastic activity; cell lines; cytotoxicity; genes; hepatoma; messenger RNA; metastasis; mitogen-activated protein kinase; patients; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; root extracts; signal transduction; transcription factors
- Abstract:
- ... Many studies have confirmed that traditional Chinese herbs exert potential anti-tumor effects. Actinidia Chinensis Planch root has been used as a traditional Chinese medicine (TCM) for thousands of years. However, the mechanism of anti-tumor effects of Actinidia Chinensis Planch root has not been clearly clarified.To explore the molecular biological mechanisms underlying the inhibitory effect of A ...
- DOI:
- 10.1016/j.jep.2019.112529
- https://doi.org/10.1016/j.jep.2019.112529
- Author:
- Shanshan Li; Yi Sun; Jin Huang; Bin Wang; Yinan Gong; Yuxin Fang; Yangyang Liu; Shenjun Wang; Yi Guo; Hong Wang; Zhifang Xu; Yongming Guo
- Source:
- Journal of ethnopharmacology 2020 v.258 pp. 112797
- ISSN:
- 0378-8741
- Subject:
- Astragalus membranaceus; Oriental traditional medicine; T-lymphocytes; active ingredients; adverse effects; antineoplastic activity; apoptosis; cell lines; drug therapy; herbal medicines; immunosuppression; macrophages; metastasis; models; neoplasm cells; neoplasms; pathophysiology; patients; risk; surgery
- Abstract:
- ... With cancer deaths increasing, the initiation, pathophysiology and curative management of cancer is receiving increasing attention. Traditional therapies such as surgery and chemoradiotherapy are often accompanied by suppression of host immunity, which increase the risk of metastasis. Astragalus membranceus (AM) is commonly utilized as one herbal medicine of traditional Chinese medicines (TCMs) wi ...
- DOI:
- 10.1016/j.jep.2020.112797
- https://doi.org/10.1016/j.jep.2020.112797
- Author:
- Bayarma M. Urbagarova; Elvira E. Shults; Vasilii V. Taraskin; Larisa D. Radnaeva; Tatyana N. Petrova; Tatyana V. Rybalova; Tatyana S. Frolova; Andrey G. Pokrovskii; Jamsranjav Ganbaatar
- Source:
- Journal of ethnopharmacology 2020 v.261 pp. 112517
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Saposhnikovia divaricata; X-ray diffraction; antineoplastic activity; antineoplastic agents; antioxidants; bergapten; cell lines; chemical composition; chemical constituents of plants; cytotoxicity; ethanol; ethyl acetate; ethyl ether; fractionation; glycosides; hemolysis; high performance liquid chromatography; homeopathic drugs; medicinal plants; models; neoplasm cells; neoplasms; petroleum; roots; scopoletin; silica gel; therapeutics; China; Mongolia; Siberia
- Abstract:
- ... Saposhnikovia divaricata (family Apiaceae) a traditional medicinal plant distributed in many provinces of China, is well known for the pharmaceutical value and has been used for rheumatic arthritis, and anxiety in children. Antiviral, antioxidant and antiproliferative activities were also mentioned. The application of this plant are recorded in the Chinese Medicine (CM) classical text the Shen Non ...
- DOI:
- 10.1016/j.jep.2019.112517
- https://doi.org/10.1016/j.jep.2019.112517
- Author:
- Jia Jia; Xigang Kang; Yanfang Liu; Jianwei Zhang
- Source:
- Applied biological chemistry 2020 v.63 no.1 pp. 67
- ISSN:
- 2468-0834
- Subject:
- 4',6-diamidino-2-phenylindole; Euodia; Oriental traditional medicine; alkaloids; antineoplastic activity; apoptosis; assays; cell growth; cell lines; cell movement; cytotoxicity; decline; exhibitions; humans; liver neoplasms; neoplasm cells; phosphatidylinositol 3-kinase; phosphorylation; proteins; staining; therapeutics; tissue repair
- Abstract:
- ... Evodiamine is an active alkaloid member found in Traditional Chinese Herb (TCH) Evodia rutaecarpa. It has been reported to exhibit remarkable biological and medicinal activities including anticancer and anti-inflammatory. This study was designed to investigate the anticancer effects of evodiamine against human liver cancer and evaluate its effects on cell migration, cell invasion, cellular apoptos ...
- DOI:
- 10.1186/s13765-020-00551-9
- https://doi.org/10.1186/s13765-020-00551-9
- Author:
- Feng Wang; Wei Li; Xiaolei Liu; Hongpeng Zhao; Jie Liu
- Source:
- Phytochemistry letters 2020 v.40 pp. 156-165
- ISSN:
- 1874-3900
- Subject:
- Chilopoda; Oriental traditional medicine; antineoplastic activity; apoptosis; caspases; cell cycle; cell lines; cyclic peptides; cytotoxicity; humans; membrane potential; mitochondrial membrane; neoplasm cells; plant biochemistry; stomach neoplasms; therapeutics; thioredoxins; toxicity testing
- Abstract:
- ... Centipede is a traditional Chinese medicine preparation widely used for gastrointestinal cancers. In this study, the structures of four novel and sixteen known centipede cyclic peptides (CCPs) were identified and their antigastrointestinal cancer potency elucidated. MTT assay demonstrated that CCP-1 [Cyclo-(L-Lys-L-His-L-Leu-L-Trp)] had excellent antitumor activity against the human tumor cell lin ...
- DOI:
- 10.1016/j.phytol.2020.09.015
- https://doi.org/10.1016/j.phytol.2020.09.015
- Author:
- Hongqing Xie; Xiaotong Li; Yajie Chen; Mingzi Lang; Zhangfei Shen; Liangen Shi
- Source:
- Journal of ethnopharmacology 2019 v.231 pp. 230-240
- ISSN:
- 0378-8741
- Subject:
- Cordyceps; Oriental traditional medicine; Western blotting; adenine; adenosine; antineoplastic activity; antineoplastic agents; apoptosis; calcium; caspase-12; caspase-3; caspase-6; caspase-8; caspase-9; cell cycle checkpoints; cell lines; cyclin-dependent kinase; cyclins; cytochrome c; cytosol; dose response; endoplasmic reticulum; endoplasmic reticulum stress; flow cytometry; fluorescent dyes; high performance liquid chromatography; humans; interphase; membrane potential; mitochondria; mitochondrial membrane; neoplasm cells; staining; stomach neoplasms; therapeutics; toxicity; toxicity testing; uridine
- Abstract:
- ... Cordyceps cicadae (Miq.) Massee is a traditional Chinese medicine that has been used for approximately 1600 years in China. C. cicadae, a member of the Cordyceps genus, exerts a therapeutic effect on many diseases, such as cancer.This study aimed to evaluate the antineoplasmic activity of C. cicadae and to identify its molecular mechanism of cell death.The toxicity of the ethanolic extract of C. c ...
- DOI:
- 10.1016/j.jep.2018.11.028
- https://doi.org/10.1016/j.jep.2018.11.028
- Author:
- Zheng LI; Qian-Qian CHEN; Christopher Wai Kei LAM; Jian-Ru GUO; Wei-Jia ZHANG; Cai-Yun WANG; Vincent Kam Wai WONG; Mei-Cun YAO; Wei ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.8 pp. 608-615
- ISSN:
- 1875-5364
- Subject:
- DNA replication; Oriental traditional medicine; adenocarcinoma; antineoplastic activity; cell cycle checkpoints; cell lines; cytotoxicity; epithelial cells; humans; hydroxyurea; interphase; liquid chromatography; lungs; mass spectrometry; metabolism; metabolomics; nucleosides; resveratrol
- Abstract:
- ... In an effort to understand the molecular events contributing to the cytotoxicity activity of resveratrol (RSV), we investigated its effects on human lung adenocarcinoma epithelial cell line A549 at different concentrations. Cellular nucleoside metabolic profiling was determined by an established liquid chromatography-mass spectrometry method in A549 cells. RSV resulted in significant decreases and ...
- DOI:
- 10.1016/S1875-5364(19)30063-9
- https://doi.org/10.1016/S1875-5364(19)30063-9
- Author:
- Qing Lin; Mengke Qu; Hirak K. Patra; Shanshan He; Luyao Wang; Xun Hu; Linyu Xiao; Yu Fu; Tao Gong; Qin He; Ling Zhang; Xun Sun; Zhirong Zhang
- Source:
- Journal of ethnopharmacology 2019 pp. -
- ISSN:
- 0378-8741
- Subject:
- Fritillaria cirrhosa; Oriental traditional medicine; Western blotting; active ingredients; adverse effects; animal models; antineoplastic activity; antineoplastic agents; blood cell counts; cancer therapy; case studies; cell lines; cytotoxicity; drug delivery systems; enzyme-linked immunosorbent assay; films (materials); herbal medicines; histopathology; immunohistochemistry; in vivo studies; inflammation; lung neoplasms; mice; transcription factor NF-kappa B
- Abstract:
- ... Bulbus Fritillaria cirrhosa D. Don (BFC) is a Chinese traditional herbal medicine that has long been used as an indispensable component in herbal prescriptions for bronchopulmonary diseases due to its well-established strong anti-inflammation and pulmonary harmonizing effects. Interestingly, there are few case reports in traditional Chinese medicine available where they found it to contribute in a ...
- DOI:
- 10.1016/j.jep.2019.112283
- https://doi.org/10.1016/j.jep.2019.112283
- Author:
- Kok-Tong Tan; Shiming Li; Yi Rong Li; Shih-Lung Cheng; Sheng-Hao Lin; Yu-Tang Tung
- Source:
- Applied biochemistry and biotechnology 2019 v.187 no.4 pp. 1328-1343
- ISSN:
- 0273-2289
- Subject:
- Oriental traditional medicine; active ingredients; adverse effects; antineoplastic activity; antineoplastic agents; apoptosis; caspase-3; caspase-8; caspase-9; cell lines; cell viability; drug synergism; drug therapy; flavones; herbs; lung neoplasms; mice; models; neoplasm cells; orange peels; paclitaxel; propidium
- Abstract:
- ... Lung cancer remains a highly prevalent disease and a leading cause of cancer-related deaths worldwide. Currently, exploring antitumor drugs derived from herbs used in traditional Chinese medicine is increasingly becoming an attractive area of research. Paclitaxel (PTX), a highly effective chemotherapeutic drug, is widely used for treating different cancers; however, the clinical use of PTX is dose ...
- DOI:
- 10.1007/s12010-018-2869-1
- https://doi.org/10.1007/s12010-018-2869-1
- Author:
- Peng-Cheng LIN; Lin-Lin JI; Xiang-Jian ZHONG; Jin-Jie LI; Xin WANG; Xiao-Ya SHANG; Sheng LIN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.1 pp. 22-26
- ISSN:
- 1875-5364
- Subject:
- Cirsium arvense; Oriental traditional medicine; animal ovaries; antineoplastic activity; cell lines; chemical structure; colorectal neoplasms; cytotoxicity; food plants; humans; inhibitory concentration 50; ovarian neoplasms; secretion; spectral analysis; triterpenoids; tumor necrosis factor-alpha
- Abstract:
- ... Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD d ...
- DOI:
- 10.1016/S1875-5364(19)30005-6
- https://doi.org/10.1016/S1875-5364(19)30005-6
- Author:
- Wen-Long Wei; Jin-Jun Hou; Xia Wang; Yang Yu; Hao-Jv Li; Zhen-Wei Li; Zi-Jin Feng; Hua Qu; Wan-Ying Wu; De-An Guo
- Source:
- Journal of ethnopharmacology 2019 v.237 pp. 215-235
- ISSN:
- 0378-8741
- Subject:
- Bufo; Oriental traditional medicine; adverse effects; anesthetics; animals; antimicrobial properties; antineoplastic activity; bioavailability; biochemical pathways; bufadienolides; cardiotoxicity; cell lines; clinical trials; databases; diarrhea; heat stroke; hydroxylation; indole alkaloids; metabolites; neoplasm cells; neoplasms; new drugs; pain; pharmacodynamics; pharmacokinetics; secretion; toxicology; vomiting
- Abstract:
- ... The animal medicine of Venenum Bufonis (VB), a product of the secretions of Bufo gargarizans Cantor or B. melanostictus Schneider, has long been used as a traditional Chinese medicine (TCM) for the treatment of sunstroke and faint, acute filthy disease - abdominal pain or vomiting and diarrhea, etc.This review is aimed at providing the comprehensive and up-to-date information of VB as regards its ...
- DOI:
- 10.1016/j.jep.2019.03.042
- https://doi.org/10.1016/j.jep.2019.03.042
- Author:
- Chaopan Zheng; Ling Han; Shihai Wu
- Source:
- Molecular biology reports 2019 v.46 no.4 pp. 3857-3864
- ISSN:
- 0301-4851
- Subject:
- Glycyrrhiza glabra; Oriental traditional medicine; alanine; antineoplastic activity; apoptosis; aspartic acid; biomarkers; biosynthesis; carcinoma; cell lines; cysteine; drugs; gas chromatography-mass spectrometry; glutamic acid; glutamine; glutathione; lipid metabolism; metabolites; metabolome; metabolomics; methionine; neoplasm cells; patients; serine; stearic acid; therapeutics; threonine
- Abstract:
- ... Although a majority of nasopharyngeal carcinoma (NPC) are undifferentiated and strongly radiosensitive, many NPC patients still have troubles in recurrence. Traditional Chinese medicine (TCM) is considered as potential therapeutic drugs in NPC. However, the effect of Glycyrrhiza glabra on NPC is limited. The present study shows the decreased proliferation and high apoptosis in G. glabra root extra ...
- DOI:
- 10.1007/s11033-019-04828-1
- https://doi.org/10.1007/s11033-019-04828-1
- Author:
- Jing Zhang; Ri-Zhen Huang; Hong-Jie Cao; An-Wei Cheng; Cheng-Shi Jiang; Zhi-Xin Liao; Chao Liu; Jin-Yue Sun
- Source:
- Industrial crops and products 2018 v.113 pp. 19-27
- ISSN:
- 0926-6690
- Subject:
- DNA replication; Oriental traditional medicine; Potentilla; antineoplastic activity; antineoplastic agents; apoptosis; carbon dioxide; cell cycle; cell growth; cell lines; essential oils; gas chromatography-mass spectrometry; ingredients; inhibitory concentration 50; neoplasm cells; neoplasms; pharmaceutical industry; roots; supercritical fluid extraction
- Abstract:
- ... Potentilla discolor has been used as the Traditional Chinese Medicine ingredient in prescription for over 400 years, and scientific evidences have confirmed its effectiveness as an anticancer agent. The present study is undertaken to assess, for the first time, the chemical composition, potential in vitro anti-tumor activities and related mechanisms of the essential oil, which was extracted from P ...
- DOI:
- 10.1016/j.indcrop.2017.12.071
- https://doi.org/10.1016/j.indcrop.2017.12.071
- Author:
- Qian Wang; Narayan Acharya; Zhongwei Liu; Xianmei Zhou; Meghan Cromie; Jia Zhu; Weimin Gao
- Source:
- Journal of ethnopharmacology 2018 v.217 pp. 140-151
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; Scutellaria barbata; Western blotting; agar; antineoplastic activity; antineoplastic agents; apoptosis; cell lines; cyclins; cytotoxicity; dose response; gene expression; herbal medicines; lung neoplasms; mechanism of action; neoplasm cells; pro-apoptotic proteins; protein synthesis; quantitative polymerase chain reaction; signal transduction
- Abstract:
- ... Experience-based herbal medicine as a complementary to modern western medicine has triggered an array of studies in quest of novel anticancer drugs. Scutellaria barbata D. Don (SB) is commonly used to treat different types of cancers, but its molecular mechanism of action is not clearly understood. In this study, we attempted to elucidate the mode of action of a traditional Chinese medicine prescr ...
- DOI:
- 10.1016/j.jep.2018.02.020
- https://doi.org/10.1016/j.jep.2018.02.020
- Author:
- Weijun Peng; Shaofang Zhang; Zheyu Zhang; Panpan Xu; Dan Mao; Siqi Huang; Biyue Chen; Chunhu Zhang; Sifang Zhang
- Source:
- Journal of ethnopharmacology 2018 v.224 pp. 140-148
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; angiogenesis; antineoplastic activity; apoptosis; carcinogenesis; cell lines; cell movement; colorectal neoplasms; flow cytometry; immunohistochemistry; metastasis; mice; models; neoplasm cells; proteins; signal transduction; therapeutics; vascular endothelial growth factors; viability
- Abstract:
- ... Traditional Chinese medicine has been utilized for the treatment of cancer. Jianpi Jiedu decoction (JPJD), a traditional Chinese medicine formula, has been used for the treatment of colorectal cancer for decades. However, the underlying molecular mechanistic basis for the effect of JPJD on colorectal cancer is poorly understood.The aim of this study was to identify the effects of JPJD on human col ...
- DOI:
- 10.1016/j.jep.2018.05.039
- https://doi.org/10.1016/j.jep.2018.05.039
- Author:
- Ming‐Cheng Chen; Hsi‐Hsien Hsu; Yuan‐Yuan Chu; Sue‐Fei Cheng; Chia‐Yao Shen; Yi‐Jiun Lin; Ray‐Jade Chen; Vijaya Padma Viswanadha; Yueh‐Min Lin; Chih‐Yang Huang
- Source:
- Environmental toxicology 2018 v.33 no.5 pp. 587-593
- ISSN:
- 1520-4081
- Subject:
- Oriental traditional medicine; adjuvants; animal models; antineoplastic activity; apoptosis; cell lines; cell viability; clinical trials; colorectal neoplasms; cytotoxicity; death; dose response; drug therapy; drugs; endoplasmic reticulum; foods; fruits; lupeol; multiple drug resistance; neoplasm cells; patients; vegetables
- Abstract:
- ... Colorectal cancer (CRC) is one of the most common cancers and causes of cancer‐related death. There are several first‐line chemotherapeutic drugs used to treat CRC. Oxaliplatin (OXA) is an alkylating cytotoxic agent that is usually combined with other chemotherapeutic drugs to treat stage II and stage III CRC. However, cancer cells commonly acquire multidrug resistance (MDR), which is a major obst ...
- DOI:
- 10.1002/tox.22544
- https://doi.org/10.1002/tox.22544
- Author:
- Zhenyu Xu; Lu Chen; Zhangang Xiao; Yanhong Zhu; Hui Jiang; Yan Jin; Cheng Gu; Yilai Wu; Lin Wang; Wen Zhang; Jian Zuo; Dexi Zhou; Jiajie Luan; Jing Shen
- Source:
- Phytomedicine 2018 v.51 pp. 58-67
- ISSN:
- 0944-7113
- Subject:
- Oriental traditional medicine; Salvia miltiorrhiza; antineoplastic activity; apoptosis; autophagy; cell cycle checkpoints; cell lines; cytotoxicity; diterpenoids; doxorubicin; drug resistance; drug therapy; flow cytometry; inhibitory concentration 50; neoplasm cells; quantitative polymerase chain reaction; stomach neoplasms
- Abstract:
- ... Gastric cancer is the fifth commonest cancer and the third cause of cancer-related deaths all over the world. The effectiveness of chemotherapy is still limited by drug resistance in gastric cancer. Tanshinones, abietane diterpenes isolated from the traditional Chinese medicine Danshen (Salvia miltiorrhiza), have exhibited versatile anticancer activities in particular the ability to overcome drug ...
- DOI:
- 10.1016/j.phymed.2018.05.012
- https://doi.org/10.1016/j.phymed.2018.05.012
- Author:
- Jiulong Zhang; Yue Luo; Xiufeng Zhao; Xiaowei Li; Kexin Li; Dawei Chen; Mingxi Qiao; Haiyang Hu; Xiuli Zhao
- Source:
- RSC advances 2016 v.6 no.114 pp. 113173-113184
- ISSN:
- 2046-2069
- Subject:
- Oriental traditional medicine; P-glycoproteins; adenosine triphosphate; antineoplastic activity; apoptosis; breast neoplasms; cell lines; cytoplasm; cytotoxicity; doxorubicin; drug delivery systems; drug therapy; histology; multiple drug resistance; neoplasm cells; quercetin; toxicity testing
- Abstract:
- ... At present, multidrug resistance (MDR) in cancer therapy is an international problem, which is caused mostly by the overexpressed P-glycoprotein (P-gp) efflux pump. To address this issue and effectively deliver chemotherapeutic drugs to cancer cells, a liposomal drug delivery system (DOX/QUE BPL) has been designed for the co-delivery of the antitumor drug doxorubicin (DOX) and the traditional Chin ...
- DOI:
- 10.1039/c6ra24173e
- https://doi.org/10.1039/c6ra24173e
- Author:
- Peng Wei; Chen Zhiyu; Tang Xu; Zheng Xiangwei
- Source:
- BMC complementary and alternative medicine 2015 v.15 no.1 pp. 33
- ISSN:
- 1472-6882
- Subject:
- Alocasia; Oriental traditional medicine; Western blotting; alternative medicine; antineoplastic activity; apoptosis; cancer therapy; caspases; cell cycle; cell lines; chromatin; cyclins; cytochrome c; cytotoxicity; ethyl acetate; flow cytometry; gene expression; humans; inhibitory concentration 50; neoplasm cells; petroleum; protein synthesis; stomach neoplasms
- Abstract:
- ... BACKGROUND: Alocasia cucullata (Lour.) G. Don was applied in traditional Chinese medicine for the treatment of cancer in Chinese Southwest area. Its antitumor effect was scrutinized in vitro and in vivo. And for the first time, the mechanism of extract of A. cucullata (EAC) against human gastric cancer cell was well examined. METHODS: To detect the most effective fraction, the antiproliferation ef ...
- DOI:
- 10.1186/s12906-015-0554-2
- https://doi.org/10.1186/s12906-015-0554-2
- Author:
- Ashwini Anjana; K.F.H Nazeer Ahamed; V. Ravichandiran; M. Sumithra; Jayaraman Anbu
- Source:
- Chinese journal of natural medicines 2014 v.12 no.2 pp. 114-120
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Sargassum wightii; antineoplastic activity; antioxidant activity; body weight; cell lines; cell proliferation; flavonoids; hematologic tests; longevity; lymphoma; mice; neoplasm cells
- Abstract:
- ... Sargassum wightii Greville is a marine brown alga belonging to the Sargassaceae family which has about 200 species. The ethanolic extract of the whole dry plant powder contained numerous phytoconstituents, including flavonoids. The study was focused on the anticancer activity of Sargassum wightii in mice.The ethanolic extract of Sargassum wightii (EESW) at two dose levels was used to examine the a ...
- DOI:
- 10.1016/S1875-5364(14)60018-2
- https://doi.org/10.1016/S1875-5364(14)60018-2
- Author:
- Yu-Xia Wang; Xiang-Xiang Gu; Di Geng; Hua-Ying Sun; Chun-Mei Wang; Gui-Xiang Jiang; Xin-Nan Hou; Chang-Hua Ma
- Source:
- Journal of ethnopharmacology 2014 v.155 no.3 pp. 1583-1588
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; albumins; alkaline phosphatase; analytical kits; antineoplastic activity; cell differentiation; cell lines; cell proliferation; clones; cytotoxicity; dose response; gamma-glutamyltransferase; hepatoma; high performance liquid chromatography; mice; mitogen-activated protein kinase; neoplasm cells; protein content; radioimmunoassays; reptiles; secretion; signal transduction; China
- Abstract:
- ... Gecko, a kind of reptile, has been widely used as a traditional Chinese medicine to treat various diseases including cancer in China for thousands of years. The aim of this study was to investigate the anti-tumor effect of AG (aqueous extracts of fresh gecko) on human hepatocellular carcinoma cell Bel-7402 in vitro and mouse H22 hepatocellular in vivo. Further to underlie the molecular mechanism o ...
- DOI:
- 10.1016/j.jep.2014.07.050
- https://doi.org/10.1016/j.jep.2014.07.050
- Author:
- Min-Yu LIU; Lin XIAO; Geng-Hui CHEN; Yong-Xiang WANG; Wei-Xia XIONG; Fei LI; Ying LIU; Xiao-Ling HUANG; Yi-Fang DENG; Zhen ZHANG; Hai-Yan SUN; Quan-Hai LIU; Ming YIN
- Source:
- Chinese journal of natural medicines 2014 v.12 no.10 pp. 768-776
- ISSN:
- 1875-5364
- Subject:
- Oriental traditional medicine; Xenorhabdus; allografting; animal models; antineoplastic activity; apoptosis; body weight; cell lines; cyclophosphamide; fluorouracil; granulocyte colony-stimulating factor; hepatoma; humans; inhibitory concentration 50; lung neoplasms; metabolites; mice; neoplasm cells; neutropenia; neutrophils; sarcoma
- Abstract:
- ... JS-38 (mitothiolore), a synthetic version of a metabolite isolated from Xenorhabdus sp., was evaluated for its anti-tumor and white blood cell (WBC) elevating activities.These anti-proliferative activities were assessed in vitro using a panel of ten cell lines. The anti-tumor activities were tested in vivo using B16 allograft mouse models and xenograft models of A549 human lung carcinoma and QGY h ...
- DOI:
- 10.1016/S1875-5364(14)60117-5
- https://doi.org/10.1016/S1875-5364(14)60117-5
- Author:
- Lijuan Zhang; Changwei Wu; Tongnan Gu; Yixin Zhang; Yang Liu
- Source:
- Analytical methods 2014 v.6 no.11 pp. 3838-3841
- ISSN:
- 1759-9679
- Subject:
- Oriental traditional medicine; X-ray diffraction; anthraquinones; antineoplastic activity; arginine; cell lines; cytotoxicity; differential scanning calorimetry; drug formulations; high performance liquid chromatography; infrared spectroscopy; mass spectrometry; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; rhizomes; rhubarb; solubilization; water solubility
- Abstract:
- ... Rhein is a natural anthraquinone, which can be isolated from the rhizomes of rhubarb, a traditional Chinese medicine herb showing antitumor activity. The poor aqueous solubility of rhein hampers its broader applications. Rhein argininate was prepared as a potential cytotoxicity formulation by co-grinding together a 1 : 1 molar mixture of rhein and l-arginine for 8 hours. Characterization of rhein ...
- DOI:
- 10.1039/c4ay00163j
- https://doi.org/10.1039/c4ay00163j
- Author:
- Florian Herrmann; Marta R. Romero; Alba G. Blazquez; Dorothea Kaufmann; Mohamed L. Ashour; Stefan Kahl; Jose J.G. Marin; Thomas Efferth; Michael Wink
- Source:
- Diversity 2011 v.3 no.4 pp. 547-580
- ISSN:
- 1424-2818
- Subject:
- Alpinia galanga; Alpinia oxyphylla; Arctium lappa; Bovine viral diarrhea virus 1; Celosia argentea var. cristata; Coptis chinensis; Euodia; Flavivirus; Glycyrrhiza; Hepatitis B virus; Hepatitis C virus; Houttuynia cordata; Kadsura; Oldenlandia diffusa; Ophioglossum; Oriental traditional medicine; Panax ginseng; Panax notoginseng; Saposhnikovia divaricata; Selaginella tamariscina; Trypanosoma brucei brucei; antineoplastic activity; antiviral properties; cattle; cell lines; cell viability; cytotoxicity; herbal medicines; humans; inhibitory concentration 50; medicinal plants; models; neoplasm cells; screening; therapeutics; China; Europe
- Abstract:
- ... In an extensive screening, the antiviral, antitrypanosomal and anticancer properties of extracts from 82 plants used in traditional Chinese medicine and European phytomedicine were determined. Several promising plants that were highly effective against hepatitis B virus (HBV), bovine viral diarrhoea virus (BVDV)—a flavivirus used here as a surrogate in vitro model of hepatitis C virus, trypanosome ...
- DOI:
- 10.3390/d3040547
- https://doi.org/10.3390/d3040547