Subject: Oriental traditional medicine / Subject term: antineoplastic activity / Text Availability: Citation in PubAg

1. Arsenic Trioxide Controls the Fate of the PML-RARα Oncoprotein by Directly Binding PML

Author:: Zhang, Xiao-Wei; Yan, Xiao-Jing; Zhou, Zi-Ren; Yang, Fei-Fei; Wu, Zi-Yu; Sun, Hong-Bin; Liang, Wen-Xue; Song, Ai-Xin; Lallemand-Breitenbach, Valérie; Jeanne, Marion; Zhang, Qun-Ye; Yang, Huai-Yu; Huang, Qiu-Hua; Zhou, Guang-Biao; Tong, Jian-Hua; Zhang, Yan; Wu, Ji-Hui; Hu, Hong-Yu; de Thé, Hugues; Chen, Sai-Juan; Chen, Zhu
Source:: Science 2010 v.328 no.5975 pp. 240-243
ISSN:: 0036-8075
Subject:: Oriental traditional medicine; antineoplastic activity; arsenic; cysteine; drugs; leukemia; mechanism of action; oligomerization; oncogene proteins; patients; post-translational modification; retinoic acid receptors; therapeutics; zinc finger motif
Abstract:: ... Arsenic, an ancient drug used in traditional Chinese medicine, has attracted worldwide interest because it shows substantial anticancer activity in patients with acute promyelocytic leukemia (APL). Arsenic trioxide (As₂O₃) exerts its therapeutic effect by promoting degradation of an oncogenic protein that drives the growth of APL cells, PML-RARα (a fusion protein containing sequences from the PML ...
DOI:: 10.1126/science.1183424
: https://doi.org/10.1126/science.1183424

2. The mechanisms of action of Tianhua on antitumor activity in lung cancer cells

Author:: Li, Chien-Te; Lin, Ching-Hsiung; Kao, Te-Yu; Wu, Ming-Fang; Yeh, Chin-Shui; Yeh, Kun-Tu; Ko, Jiunn-Liang
Source:: Pharmaceutical biology 2010 v.48 no.11 pp. 1302-1309
ISSN:: 1388-0209
Subject:: Oriental traditional medicine; Trichosanthes kirilowii; adenocarcinoma; animal models; antineoplastic activity; apoptosis; carcinogenesis; cell cycle; cell growth; cytotoxicity; enzyme-linked immunosorbent assay; flow cytometry; humans; immunomodulation; interferon-gamma; lung neoplasms; lymphocytes; mechanism of action; medicinal plants; metastasis; neoplasm cells; telomerase; telomeres; therapeutics
Abstract:: ... Context: Tianhua (TH-R) is extracted from Trichosanthes kirilowii Maxim (Cucurbitaceae) containing trichosanthin, a traditional Chinese medicine, which has been locally reported to have good anticancer effects in vivo in both animal and human models. However, there have been several reports that trichosanthin has an anticancer effect involving apoptosis. Objective: To investigate other anticancer ...
DOI:: 10.3109/13880201003789432
: https://doi.org/10.3109/13880201003789432

3. Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

Author:: Florian Herrmann; Marta R. Romero; Alba G. Blazquez; Dorothea Kaufmann; Mohamed L. Ashour; Stefan Kahl; Jose J.G. Marin; Thomas Efferth; Michael Wink
Source:: Diversity 2011 v.3 no.4 pp. 547-580
ISSN:: 1424-2818
Subject:: Alpinia galanga; Alpinia oxyphylla; Arctium lappa; Bovine viral diarrhea virus 1; Celosia argentea var. cristata; Coptis chinensis; Euodia; Flavivirus; Glycyrrhiza; Hepatitis B virus; Hepatitis C virus; Houttuynia cordata; Kadsura; Oldenlandia diffusa; Ophioglossum; Oriental traditional medicine; Panax ginseng; Panax notoginseng; Saposhnikovia divaricata; Selaginella tamariscina; Trypanosoma brucei brucei; antineoplastic activity; antiviral properties; cattle; cell lines; cell viability; cytotoxicity; herbal medicines; humans; inhibitory concentration 50; medicinal plants; models; neoplasm cells; screening; therapeutics; China; Europe
Abstract:: ... In an extensive screening, the antiviral, antitrypanosomal and anticancer properties of extracts from 82 plants used in traditional Chinese medicine and European phytomedicine were determined. Several promising plants that were highly effective against hepatitis B virus (HBV), bovine viral diarrhoea virus (BVDV)—a flavivirus used here as a surrogate in vitro model of hepatitis C virus, trypanosome ...
DOI:: 10.3390/d3040547
: https://doi.org/10.3390/d3040547

4. Purification of a protein from coelomic fluid of the earthworm Eisenia foetida and evaluation of its hemolytic, antibacterial, and antitumor activities

Author:: Hua, Zhang; Wang, Yan-Hong; Cao, Hong-Wei; Pu, Li-Jun; Cui, Yu-Dong
Source:: Pharmaceutical biology 2011 v.49 no.3 pp. 269-275
ISSN:: 1388-0209
Subject:: Eisenia fetida; Escherichia coli; Lumbricus rubellus; Oriental traditional medicine; Staphylococcus aureus; antibacterial properties; antineoplastic activity; dose response; earthworms; erythrocytes; gel chromatography; hemolysis; inhibitory concentration 50; ion exchange chromatography; minimum inhibitory concentration; molecular weight; polyacrylamide gel electrophoresis; sodium dodecyl sulfate; ultrafiltration
Abstract:: ... Context: Earthworm Eisenia foetida (Lumbricus rubellus), a traditional Chinese medicine, is used for treating many diseases, and its coelomic fluid has extensive biological functions. Objective: The hemolytic, antibacterial and antitumor activities of an earthworm protein purified from coelomic fluid were investigated in vitro. Materials and methods: We used ultrafiltration, gel chromatography, an ...
DOI:: 10.3109/13880209.2010.508498
: https://doi.org/10.3109/13880209.2010.508498

5. Composition–activity relationship modeling to predict the antitumor activity for quality control of curcuminoids from Curcuma longa L. (turmeric)

Author:: Jian-Lan Jiang; Huan Zhang; Pei-Pei Zhou; Sheng-Nan Han; Ya-Di Han; Ying-Jin Yuan
Source:: Analytical methods 2013 v.5 no.3 pp. 641-647
ISSN:: 1759-9679
Subject:: Curcuma longa; Oriental traditional medicine; analytical methods; antineoplastic activity; chemical composition; human cell lines; model validation; quality control; regression analysis; support vector machines; turmeric
Abstract:: ... Composition–activity relationship (CAR) modeling is a novel and appropriate method to evaluate the quality of traditional Chinese medicines (TCMs) for it can correlate the chemical constituents of TCMs with their bioactivity. In this paper, we studied the relationship between the antitumor activity on HeLa cells and the curcuminoids from thirty one batches of Curcuma longa L. using support vector ...
DOI:: 10.1039/c2ay26192h
: https://doi.org/10.1039/c2ay26192h

6. Lignans extracted from Vitex negundo possess cytotoxic activity by G2/M phase cell cycle arrest and apoptosis induction

Author:: Hong Xin; Ying Kong; Yong Wang; Yingjun Zhou; Yizhun Zhu; Dapeng Li; Wenfu Tan
Source:: Phytomedicine 2013 v.20 pp. 640-647
ISSN:: 0944-7113
Subject:: 4',6-diamidino-2-phenylindole; Oriental traditional medicine; Vitex negundo; Western blotting; antineoplastic activity; apoptosis; breast neoplasms; cell cycle checkpoints; cyclins; cytotoxicity; flow cytometry; histones; inhibitory concentration 50; lignans; liver neoplasms; neoplasm cells; phosphorylation; staining
Abstract:: ... Evn-50 is a lignan compounds mixture extracted from Vitex negundo, a widely used herb in traditional Chinese medicine. This study is aimed to define the spectrum of cytotoxic activity of EVn-50, and also to investigate mechanisms underlying the anticancer actions via assessing the influence on cell cycle using EVn-50, and the lignan compound VB1 purified from EVn-50. The cytotoxic effect of EVn-50 ...
DOI:: 10.1016/j.phymed.2013.02.002
: https://doi.org/10.1016/j.phymed.2013.02.002

7. Scutellaria barbata D. Don extract synergizes the antitumor effects of low dose 5-fluorouracil through induction of apoptosis and metabolism

Author:: Huanli Xu; Jinmei Yu; Yan Sun; Xiaona Xu; Li Li; Ming Xue; Guanhua Du
Source:: Phytomedicine 2013 v.20 pp. 897-903
ISSN:: 0944-7113
Subject:: Oriental traditional medicine; Scutellaria barbata; adjuvants; adverse effects; antineoplastic activity; apoptosis; caspase-3; drug therapy; fluorouracil; growth retardation; high performance liquid chromatography; messenger RNA; metabolism
Abstract:: ... Traditional Chinese medicines have been recognized as a new source of anticancer drugs or chemotherapy adjuvant to enhance the efficacy of chemotherapy and to ameliorate the side effects. This study aimed to investigate the antitumor effects of combined Scutellaria barbata D. Don extract (SBE) and 5-FU treatment in vitro and in vivo and the potential mechanisms. SBE was prepared and analyzed by HP ...
DOI:: 10.1016/j.phymed.2013.03.025
: https://doi.org/10.1016/j.phymed.2013.03.025

8. Anti-inflammatory effect of Phellinus linteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages

Author:: Minjung Song; Hye-Jin Park
Source:: Journal of ethnopharmacology 2014 v.154 no.2 pp. 311-318
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Phellinus linteus; Western blotting; animal models; anti-inflammatory activity; antineoplastic activity; brown rice; colitis; colon; dextran; filtration; gamma-aminobutyric acid; inducible nitric oxide synthase; inflammation; lipopolysaccharides; macrophages; mice; mitogen-activated protein kinase; neoplasms; nitric oxide; prostaglandin synthase; prostaglandins; sodium; sulfasalazine; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Phellinus linteus is a herb used in traditional Asian medicine to treat stomachache, inflammation, and tumors. Recent studies show that the extract of Phellinus linteus has anti-inflammatory and antitumor activities. However, Phellinus linteus extract has limitation of high cost and limited availability because of supply shortage. Here, we grew Phellinus linteus on germinated brown rice to address ...
DOI:: 10.1016/j.jep.2013.12.059
: https://doi.org/10.1016/j.jep.2013.12.059

9. Anti-tumor and immunomodulatory activity of peptide fraction from the larvae of Musca domestica

Author:: Hong-Xiang Sun; Li-Qing Chen; Juan Zhang; Feng-Yang Chen
Source:: Journal of ethnopharmacology 2014 v.153 no.3 pp. 831-839
ISSN:: 0378-8741
Subject:: GATA transcription factors; Musca domestica; Oriental traditional medicine; antibodies; antineoplastic activity; antineoplastic agents; blood serum; cell-mediated immunity; coma; cytotoxic T-lymphocytes; gene expression; immunoglobulin G; immunomodulators; insects; interferon-gamma; interleukin-10; larvae; mechanism of action; messenger RNA; mice; natural killer cells; necrosis; oral administration; osteomyelitis; protein content; sarcoma; splenocytes; stomach neoplasms; transcription (genetics)
Abstract:: ... The larvae of Musca domestica (Diptera: Muscidae) have been used traditionally for malnutritional stagnation, decubital necrosis, osteomyelitis, ecthyma and lip scald and also to treat coma and gastric cancer in the traditional Chinese medicine. Its in vitro antitumor activity and immunomodulatory effect in naïve mice in relation to the traditional uses were also reported. However, the in vivo ant ...
DOI:: 10.1016/j.jep.2014.03.052
: https://doi.org/10.1016/j.jep.2014.03.052

10. Anticancer activity of Sargassum wightii Greville on Dalton's ascitic lymphoma

Author:: Ashwini Anjana; K.F.H Nazeer Ahamed; V. Ravichandiran; M. Sumithra; Jayaraman Anbu
Source:: Chinese journal of natural medicines 2014 v.12 no.2 pp. 114-120
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Sargassum wightii; antineoplastic activity; antioxidant activity; body weight; cell lines; cell proliferation; flavonoids; hematologic tests; longevity; lymphoma; mice; neoplasm cells
Abstract:: ... Sargassum wightii Greville is a marine brown alga belonging to the Sargassaceae family which has about 200 species. The ethanolic extract of the whole dry plant powder contained numerous phytoconstituents, including flavonoids. The study was focused on the anticancer activity of Sargassum wightii in mice.The ethanolic extract of Sargassum wightii (EESW) at two dose levels was used to examine the a ...
DOI:: 10.1016/S1875-5364(14)60018-2
: https://doi.org/10.1016/S1875-5364(14)60018-2

11. Chemical profiles and anticancer effects of saponin fractions of different polarity from the leaves of Panax notoginseng

Author:: MAO Qian; LI Yi; LI Song-Lin; YANG Jie; ZHANG Ping-Hu; WANG Qiang
Source:: Chinese journal of natural medicines 2014 v.12 no.1 pp. 30-37
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Panax notoginseng; adenocarcinoma; antineoplastic activity; cytotoxicity; ethanol; hepatoma; high performance liquid chromatography; human cell lines; humans; leaves; lung neoplasms; pancreatic neoplasms; porous media; saponins
Abstract:: ... To evaluate the chemical profiles and cytotoxic effects among the total saponin fraction (TSF), 25% ethanol fraction (25EF), 50% ethanol fraction (50EF), and 85% ethanol fraction (85EF) prepared by macroporous resin from the leaves of Panax notoginseng.The simultaneous determination of thirteen main saponins, as well as the chemical profiles of saponin fractions of different polarity, was made by ...
DOI:: 10.1016/S1875-5364(14)60006-6
: https://doi.org/10.1016/S1875-5364(14)60006-6

12. Cyto-/genotoxic effects of the ethanol extract of Chan Su, a traditional Chinese medicine, in human cancer cell lines

Author:: Sunyeong Lee; Younghyun Lee; Young Joo Choi; Kyung-Suk Han; Hai Won Chung
Source:: Journal of ethnopharmacology 2014 v.152 no.2 pp. 372-376
ISSN:: 0378-8741
Subject:: Bufo bufo; DNA; Oriental traditional medicine; T-lymphocytes; antineoplastic activity; apoptosis; breast neoplasms; comet assay; dose response; ethanol; flow cytometry; genotoxicity; human cell lines; lung neoplasms; micronucleus tests; neoplasm cells; propidium; staining; therapeutics; venoms; viability
Abstract:: ... Chan Su, an ethanolic extract from skin and parotid venom glands of the Bufo bufo gargarizans Cantor, is widely used as a traditional Chinese medicine for cancer therapy. Although the anti-cancer properties of Chan Su have been investigated, no information exists regarding whether Chan Su has genotoxic effects in cancer cells. The aim of the present study was to examine the cyto-/genotoxic effect ...
DOI:: 10.1016/j.jep.2014.01.023
: https://doi.org/10.1016/j.jep.2014.01.023

13. DT-13, a saponin of dwarf lilyturf tuber, exhibits anti-cancer activity by down-regulating C-C chemokine receptor type 5 and vascular endothelial growth factor in MDA-MB-435 cells

Author:: ZHAO Ren-Ping; LIN Sen-Sen; Sheng-Tao YUAN; Bo-Yang YU; Xian-Shu BAI; Li SUN; Lu-Yong ZHANG
Source:: Chinese journal of natural medicines 2014 v.12 no.1 pp. 24-29
ISSN:: 1875-5364
Subject:: CCR5 receptor; Ophiopogon japonicus; Oriental traditional medicine; Western blotting; adhesion; antineoplastic activity; cell proliferation; hypoxia-inducible factor 1; lungs; messenger RNA; metastasis; mice; normoxia; protein content; protein synthesis; quantitative polymerase chain reaction; saponins; tubers; vascular endothelial growth factors
Abstract:: ... To investigate the anticancer activity of DT-13 under normoxia and determine the underlying mechanisms of action.MDA-MB-435 cell proliferation, migration, and adhesion were performed to assess the anticancer activity of DT-13, a saponin from Ophiopogon japonicus, in vitro. In addition, the effects of DT-13 on tumor growth and metastasis in vivo were evaluated by orthotopic implantation of MDA-MB-4 ...
DOI:: 10.1016/S1875-5364(14)60005-4
: https://doi.org/10.1016/S1875-5364(14)60005-4

14. Differentiation of bel-7402 human hepatocarcinoma cells induced by aqueous extracts of fresh gecko (AG) and its anti-tumor activity in vivo

Author:: Yu-Xia Wang; Xiang-Xiang Gu; Di Geng; Hua-Ying Sun; Chun-Mei Wang; Gui-Xiang Jiang; Xin-Nan Hou; Chang-Hua Ma
Source:: Journal of ethnopharmacology 2014 v.155 no.3 pp. 1583-1588
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; albumins; alkaline phosphatase; analytical kits; antineoplastic activity; cell differentiation; cell lines; cell proliferation; clones; cytotoxicity; dose response; gamma-glutamyltransferase; hepatoma; high performance liquid chromatography; mice; mitogen-activated protein kinase; neoplasm cells; protein content; radioimmunoassays; reptiles; secretion; signal transduction; China
Abstract:: ... Gecko, a kind of reptile, has been widely used as a traditional Chinese medicine to treat various diseases including cancer in China for thousands of years. The aim of this study was to investigate the anti-tumor effect of AG (aqueous extracts of fresh gecko) on human hepatocellular carcinoma cell Bel-7402 in vitro and mouse H22 hepatocellular in vivo. Further to underlie the molecular mechanism o ...
DOI:: 10.1016/j.jep.2014.07.050
: https://doi.org/10.1016/j.jep.2014.07.050

15. Dynamic monitoring of the cytotoxic effects of protoberberine alkaloids from Rhizoma Coptidis on HepG2 cells using the xCELLigence system

Author:: Le-Le ZHANG; Li-Na MA; Dan YAN; Cong-En ZHANG; Dan GAO; Yin XIONG; Fei-Ya SHENG; Xiao-Ping DONG; Xiao-He XIAO
Source:: Chinese journal of natural medicines 2014 v.12 no.6 pp. 428-435
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; antineoplastic activity; berberine; cell growth; cisplatin; cytotoxicity; death; human cell lines; in vitro studies; inhibitory concentration 50; monitoring; screening
Abstract:: ... To investigate the cytotoxic effects of the six protoberberine alkaloids (PAs) from Rhizoma Coptidis on HepG2 cells.A systematic screening was conducted to investigate the dynamic response of HepG2 cells to the PAs using the impedance-based xCELLigence system. Cisplatin was selected as the positive control. The real time, concentration-response curves and the 50% inhibitory concentrations (IC50) w ...
DOI:: 10.1016/S1875-5364(14)60067-4
: https://doi.org/10.1016/S1875-5364(14)60067-4

16. Eupafolin, a skin whitening flavonoid isolated from Phyla nodiflora, downregulated melanogenesis: Role of MAPK and Akt pathways

Author:: Horng-Huey Ko; Yao-Chang Chiang; Ming-Horng Tsai; Chan-Jung Liang; Lee-Fen Hsu; Shu-Yu Li; Moo-Chin Wang; Feng-Lin Yen; Chiang-Wen Lee
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 386-393
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Phyla nodiflora; Western blotting; anti-inflammatory activity; antineoplastic activity; cytotoxicity; dose response; enzyme activity; enzyme-linked immunosorbent assay; flavonoids; gene expression regulation; herbal tea; hyperpigmentation; inflammation; melanin; melanogenesis; melanoma; mice; mitogen-activated protein kinase; phosphorylation; protein content; protein synthesis; transcription (genetics); transcription factors
Abstract:: ... In hyperpigmentation disorders marked by melanin overproduction in the skin, including melisma and freckles, melanogenesis is caused by tyrosinase overexpression. Natural medicinal resources, like Phyla nodiflora, a traditional Chinese herbal medicine, have been used for a long time to management of dermatological conditions, such as skin inflammation and melanogenesis. Eupafolin, a functional fla ...
DOI:: 10.1016/j.jep.2013.10.054
: https://doi.org/10.1016/j.jep.2013.10.054

17. Evaluation of the indicative roles of seven potential biomarkers on hepato-nephrotoxicity induced by Genkwa Flos

Author:: Yu Jiang; Liqiang Gu; Ruowen Zhang; Yuanyuan Zhang; Lunhui Zhang; Ping Ju; Bingjie Ma; Kexia Zhang; Kaishun Bi; Xiaohui Chen
Source:: Journal of ethnopharmacology 2014 v.158 pp. 317-324
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; antineoplastic activity; biomarkers; blood chemistry; blood serum; cholic acid; hippuric acid; histopathology; ingestion; kidneys; laboratory techniques; liquid chromatography; liver; males; mass spectrometry; medicinal plants; oral administration; overdose; rats; sulfates; taurine; tissues; uric acid; urine
Abstract:: ... Genkwa Flos, a classical traditional Chinese medicine, is used for the definite antitumor activity and tends to be taken overdose or long term in these years. While the excessive application can result in damage to liver and kidney. In this study, the indicative roles of seven potential biomarkers were evaluated to investigate hepato-nephrotoxicity in the early stages after oral administration of ...
DOI:: 10.1016/j.jep.2014.10.055
: https://doi.org/10.1016/j.jep.2014.10.055

18. Hedyotis diffusa Willd extract inhibits the growth of human glioblastoma cells by inducing mitochondrial apoptosis via AKT/ERK pathways

Author:: Yan Zhang; Rui-Fan Xie; Qun-Gen Xiao; Ran Li; Xiao-Li Shen; Xin-Gen Zhu
Source:: Journal of ethnopharmacology 2014 v.158 pp. 404-411
ISSN:: 0378-8741
Subject:: Oldenlandia diffusa; Oriental traditional medicine; antineoplastic activity; apoptosis; caspase-3; cell cycle checkpoints; colorimetry; dose response; enzyme activity; flow cytometry; inflammation; membrane potential; mitochondria; mitochondrial membrane; mitogen-activated protein kinase; neoplasms; protein synthesis; proteins; spectrophotometers
Abstract:: ... Hedyotis diffusa Willd (Rubiaceae) (HDW) has been widely applied for the treatment of tumors, inflammation and toxication in traditional Chinese medicine. The antitumor effect of HDW on glioblastoma has been rarely reported. We aim to evaluate the activity of this extract and explore the underlying mechanism in U87 human glioblastoma cell line.Cytotoxicity of HDW extract on U87 cells was measured ...
DOI:: 10.1016/j.jep.2014.10.017
: https://doi.org/10.1016/j.jep.2014.10.017

19. Hypericin: chemical synthesis and biosynthesis

Author:: Lin-Fang HUANG; Zeng-Hui WANG; Shi-Lin CHEN
Source:: Chinese journal of natural medicines 2014 v.12 no.2 pp. 81-88
ISSN:: 1875-5364
Subject:: Hypericum; Oriental traditional medicine; antineoplastic activity; biosynthesis; chemists; hypericin; synthesis
Abstract:: ... Hypericin is one of the most important phenanthoperylene quinones extracted mainly from plants of the genus Hypericum belonging to the sections Euhypericum and Campylosporus of Keller's classification. Widespread attention to the antiviral and anti-tumor properties of hypericin has spurred investigations of the chemical synthesis and biosynthesis of this unique compound. However, the synthetic str ...
DOI:: 10.1016/S1875-5364(14)60014-5
: https://doi.org/10.1016/S1875-5364(14)60014-5

20. Inhibitory activities of Lignum Sappan extractives on growth and growth-related signaling of tumor cells

Author:: Qing ZHANG; Jing-Li LIU; Xiao-Man QI; Chun-Ting QI; Qiang YU
Source:: Chinese journal of natural medicines 2014 v.12 no.8 pp. 607-612
ISSN:: 1875-5364
Subject:: Caesalpinia sappan; Oriental traditional medicine; active ingredients; animal models; antineoplastic activity; cytotoxicity; ethyl acetate; flow cytometry; humans; luciferase; mitosis; neoplasm cells; neoplasms; plasmids; transcription factor NF-kappa B
Abstract:: ... To investigate the active constituents of Lignum Sappan (Caesalpinia sappan L.) on growth-related signaling and cell mitosis.The influence of the ethyl acetate (EtOAc) extract of Lignum Sappan and its constituents on growth-related signaling were evaluated by a luciferase assay in cells stably-transfected with NF-κB, STAT1, or STAT3 responsive luciferase reporter plasmid. The inhibitory effect on ...
DOI:: 10.1016/S1875-5364(14)60092-3
: https://doi.org/10.1016/S1875-5364(14)60092-3

21. Lobelia chinensis: chemical constituents and anticancer activity perspective

Author:: Mei-Wan CHEN; Wen-Rong CHEN; Jin-Ming ZHANG; Xiao-Ying LONG; Yi-Tao WANG
Source:: Chinese journal of natural medicines 2014 v.12 no.2 pp. 103-107
ISSN:: 1875-5364
Subject:: Lobelia chinensis; Oriental traditional medicine; antineoplastic activity; antineoplastic agents; breathing; chemical composition; flavonoids; piperidine alkaloids; research and development
Abstract:: ... Research has demonstrated that many chemical constituents dominated by piperidine alkaloids and flavonoids, such as lobelanidine, lobeline, and lobelanine, have been obtained from Lobelia chinensis Lour. Experimental studies and clinical applications have also indicated that L. chinensis possesses a number of pharmacological activities (e.g., diuretic, choleretic, breathing excitement, anti-venom, ...
DOI:: 10.1016/S1875-5364(14)60016-9
: https://doi.org/10.1016/S1875-5364(14)60016-9

22. Mechanism of action of (–)-epigallocatechin-3-gallate: auto-oxidation-dependent activation of extracellular signal-regulated kinase 1/2 in Jurkat cells

Author:: Shuang SONG; Ye-Wei HUANG; Yang TIAN; Xuan-Jun WANG; Jun SHENG
Source:: Chinese journal of natural medicines 2014 v.12 no.9 pp. 654-662
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Western blotting; antineoplastic activity; catalase; dose response; epigallocatechin gallate; high performance liquid chromatography; hydrogen peroxide; mechanism of action; mitogen-activated protein kinase; neoplasm cells; oxidation; phosphorylation; polyphenols; superoxide dismutase; tea
Abstract:: ... (–)-Epigallocatechin-3-gallate (EGCG), a major compound of tea polyphenols, exhibited antitumor activity in previous studies. In these studies, EGCG usually inhibits EGFR, and impairs the ERK1/2 phosphorylation in tumor cells. The aim was to clarify the mechanism of ERK1/2 activation induced by EGCG.Jurkat and 293T cells were treated with EGCG in different culture conditions. Western Blotting (WB) ...
DOI:: 10.1016/S1875-5364(14)60100-X
: https://doi.org/10.1016/S1875-5364(14)60100-X

23. Oral JS-38, a metabolite from Xenorhabdus sp., has both anti-tumor activity and the ability to elevate peripheral neutrophils

Author:: Min-Yu LIU; Lin XIAO; Geng-Hui CHEN; Yong-Xiang WANG; Wei-Xia XIONG; Fei LI; Ying LIU; Xiao-Ling HUANG; Yi-Fang DENG; Zhen ZHANG; Hai-Yan SUN; Quan-Hai LIU; Ming YIN
Source:: Chinese journal of natural medicines 2014 v.12 no.10 pp. 768-776
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Xenorhabdus; allografting; animal models; antineoplastic activity; apoptosis; body weight; cell lines; cyclophosphamide; fluorouracil; granulocyte colony-stimulating factor; hepatoma; humans; inhibitory concentration 50; lung neoplasms; metabolites; mice; neoplasm cells; neutropenia; neutrophils; sarcoma
Abstract:: ... JS-38 (mitothiolore), a synthetic version of a metabolite isolated from Xenorhabdus sp., was evaluated for its anti-tumor and white blood cell (WBC) elevating activities.These anti-proliferative activities were assessed in vitro using a panel of ten cell lines. The anti-tumor activities were tested in vivo using B16 allograft mouse models and xenograft models of A549 human lung carcinoma and QGY h ...
DOI:: 10.1016/S1875-5364(14)60117-5
: https://doi.org/10.1016/S1875-5364(14)60117-5

24. Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity

Author:: Li Tao; Sheng Wang; Yang Zhao; Xiaobo Sheng; Aiyun Wang; Shizhong Zheng; Yin Lu
Source:: Phytomedicine 2014 v.21 pp. 1473-1482
ISSN:: 0944-7113
Subject:: Oriental traditional medicine; active sites; antineoplastic activity; benzoic acid; blood; blood circulation; caffeic acid; carcinogenesis; cell growth; cinnamic acid; danshensu; gallic acid; herbs; hydrogen bonding; medicinal plants; metastasis; neoplasm cells; neoplasms; prostaglandin synthase; rosmarinic acid; salvianolic acid; therapeutics
Abstract:: ... Integrated research of herbs and formulas characterized by functions of promoting blood circulation and removing blood stasis is one of the most active fields in traditional Chinese medicine. This paper strives to demonstrate the roles of a homologous series of phenolcarboxylic acids from these medicinal herbs in cancer treatment via targeting cyclooxygenase-2 (COX-2), a well-recognized mediator i ...
DOI:: 10.1016/j.phymed.2014.05.001
: https://doi.org/10.1016/j.phymed.2014.05.001

25. Preparation, characterization and cytotoxic activity of rhein argininate

Author:: Lijuan Zhang; Changwei Wu; Tongnan Gu; Yixin Zhang; Yang Liu
Source:: Analytical methods 2014 v.6 no.11 pp. 3838-3841
ISSN:: 1759-9679
Subject:: Oriental traditional medicine; X-ray diffraction; anthraquinones; antineoplastic activity; arginine; cell lines; cytotoxicity; differential scanning calorimetry; drug formulations; high performance liquid chromatography; infrared spectroscopy; mass spectrometry; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; rhizomes; rhubarb; solubilization; water solubility
Abstract:: ... Rhein is a natural anthraquinone, which can be isolated from the rhizomes of rhubarb, a traditional Chinese medicine herb showing antitumor activity. The poor aqueous solubility of rhein hampers its broader applications. Rhein argininate was prepared as a potential cytotoxicity formulation by co-grinding together a 1 : 1 molar mixture of rhein and l-arginine for 8 hours. Characterization of rhein ...
DOI:: 10.1039/c4ay00163j
: https://doi.org/10.1039/c4ay00163j

26. Prescription patterns of Chinese herbal products for post-surgery colon cancer patients in Taiwan

Author:: Te-Hsin Chao; Pin-Kuei Fu; Chiung-Hung Chang; Shih-Ni Chang; Frank Chiahung Mao; Ching-Heng Lin
Source:: Journal of ethnopharmacology 2014 v.155 no.1 pp. 702-708
ISSN:: 0378-8741
Subject:: Oldenlandia diffusa; Oriental traditional medicine; Scutellaria barbata; antineoplastic activity; colorectal neoplasms; cross-sectional studies; databases; digestive system; food intake; ghrelin; health insurance; herbal medicines; ingredients; patients; secretion; surgery; Taiwan
Abstract:: ... Traditional Chinese medicine (TCM) is commonly provided to cancer patients, however, the patterns of prescriptions for this type of medicine in Taiwan are unclear. This study aimed to evaluate the use of traditional Chinese medicine products in colon cancer patients post-surgery in Taiwan and to research patterns of TCM.This was a cross-sectional study of newly diagnosed colon cancer patients who ...
DOI:: 10.1016/j.jep.2014.06.012
: https://doi.org/10.1016/j.jep.2014.06.012

27. Schisandra polysaccharide evokes immunomodulatory activity through TLR 4-mediated activation of macrophages

Author:: Ting Zhao; Yun Feng; Jing Li; Riwen Mao; Ye Zou; Weiwei Feng; Daheng Zheng; Wei Wang; Yao Chen; Liuqing Yang; Xiangyang Wu
Source:: International journal of biological macromolecules 2014 v.65 pp. 33-40
ISSN:: 0141-8130
Subject:: Oriental traditional medicine; Schisandra chinensis; Toll-like receptor 4; antineoplastic activity; hemolysins; immunoglobulins; immunomodulation; inducible nitric oxide synthase; macrophage activation; macrophages; mechanism of action; messenger RNA; mice; neoplasms; nitric oxide; polysaccharides; spleen; thymus gland; tumor necrosis factor-alpha
Abstract:: ... Schisandra chinensis (Turcz.) Baill has been used in traditional Chinese medicine for centuries. Previous studies have shown that Schisandra polysaccharide (SCPP11) has robust antitumor activity in vivo. In this study, the immunomodulatory activity and mechanisms of action of SCPP11 were investigated further to reveal its mechanism of action against tumors. Results showed that SCPP11 increased the ...
DOI:: 10.1016/j.ijbiomac.2014.01.018
: https://doi.org/10.1016/j.ijbiomac.2014.01.018

28. Sedum sarmentosum Bunge extract exerts renal anti-fibrotic effects in vivo and in vitro

Author:: Yongheng Bai; Hong Lu; Ge Zhang; Cunzao Wu; Chengcheng Lin; Yong Liang; Bicheng Chen
Source:: Life sciences 2014 v.105 no.1-2 pp. 22-30
ISSN:: 0024-3205
Subject:: Oriental traditional medicine; Sedum sarmentosum; antineoplastic activity; aristolochic acids; blood serum; creatinine; epithelial cells; epithelium; extracellular matrix; fibrosis; kidney diseases; rats; renal function; therapeutics; transforming growth factor beta 1
Abstract:: ... Sedum sarmentosum Bunge, a traditional Chinese herbal medicine, has a wide range of clinical effects, including anti-oxidation, anti-inflammation, and anti-cancer properties. In this study, we determined whether S. sarmentosum Bunge Extract (SSBE) has anti-fibrotic effects on renal tissues.We investigated the effects of SSBE on aristolochic acid (AA)-induced injury to renal tubular epithelial cell ...
DOI:: 10.1016/j.lfs.2014.04.013
: https://doi.org/10.1016/j.lfs.2014.04.013

29. Subchronic oral toxicity of evodia fruit powder in rats

Author:: Duyeol Kim; Yong-Hoon Lee; Sun Hee Park; Mi Ju Lee; Myoung Jun Kim; Ho-Song Jang; Jung-Min Lee; Hye-Yeong Lee; Beom Seok Han; Woo-Chan Son; Ji Hyeon Seok; Jong Kwon Lee; Jayoung Jeong; Jin Seok Kang; Jong-Koo Kang
Source:: Journal of ethnopharmacology 2014 v.151 pp. 1072-1078
ISSN:: 0378-8741
Subject:: Euodia; Oriental traditional medicine; alanine transaminase; antineoplastic activity; blood chemistry; blood serum; cholesterol; dietary supplements; excretion; females; glucose; hematology; histopathology; liver; males; oral administration; rats; spermatozoa; tissue weight; toxicity; triacylglycerols; urinalysis
Abstract:: ... Evodia, a fruit from Evodia rutaecarpa, has been used in oriental medicine, and since its various pharmaceutical actions, including anti-cancer activity, have become known, evodia has been widely used as a dietary supplement. However, information regarding its toxicity is limited.Evodia fruit from Evodia rutaecarpa (Juss.) Benth. var. officinalis (Dode) Huang (0, 25, 74, 222, 667, and 2000mg/kg) w ...
DOI:: 10.1016/j.jep.2013.12.006
: https://doi.org/10.1016/j.jep.2013.12.006

30. Synthesis, characterization, and anti-cancer activity of emodin-Mn(II) metal complex

Author:: Li YANG; Jun TAN; Bo-Chu WANG; Lian-Cai ZHU
Source:: Chinese journal of natural medicines 2014 v.12 no.12 pp. 937-942
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; antineoplastic activity; antineoplastic agents; apoptosis; atomic absorption spectrometry; cytotoxicity; differential scanning calorimetry; emodin; flow cytometry; human cell lines; humans; inhibitory concentration 50; interphase; manganese; neoplasm cells; neoplasms; nuclear magnetic resonance spectroscopy; thermogravimetry; ultraviolet-visible spectroscopy; viability
Abstract:: ... To synthesize and characterize a novel metal complex of Mn (II) with emodin, and evaluate its anti-cancer activity. The elemental analyses, IR, UV-vis, atomic absorption spectroscopy, TG-DSC, ¹H NMR, and ¹³C NMR data were used to characterize the structure of the complex. The cytotoxicity of the complex against the human cancer cell lines HepG2, HeLa, MCF-7, B16, and MDA-MB-231 was tested by the M ...
DOI:: 10.1016/S1875-5364(14)60137-0
: https://doi.org/10.1016/S1875-5364(14)60137-0

31. A UPLC–MS/MS method for in vivo and in vitro pharmacokinetic studies of psoralenoside, isopsoralenoside, psoralen and isopsoralen from Psoralea corylifolia extract

Author:: Yue-Fei Wang; Ya-Nan Liu; Wen Xiong; Dong-Mei Yan; Yan Zhu; Xiu-Mei Gao; Yan-Tong Xu; Ai-Di Qi
Source:: Journal of ethnopharmacology 2014 v.151 no.1 pp. 609-617
ISSN:: 0378-8741
Subject:: Cullen corylifolium; Oriental traditional medicine; antibacterial properties; antineoplastic activity; asthma; biochemical pathways; biotransformation; dried fruit; formic acid; gastrointestinal system; glycosides; guidelines; intestinal microorganisms; oral administration; osteoporosis; pharmacokinetics; psoralen; quantitative analysis; rats; tandem mass spectrometry; ultra-performance liquid chromatography
Abstract:: ... The dried fruit of Psoralea corylifolia L. has been used to prevent and treat vitiligo, osteoporosis, arthralgia and asthma in Traditional Chinese Medicine for some 1600 years. Psoralen (P), isopsoralen (IP), psoralenoside (PO) and isopsoralenoside (IPO) are the major coumarins and coumarin-related benzofuran glycosides in Psoraleae Fructus, which have been reported to show estrogen-like activity, ...
DOI:: 10.1016/j.jep.2013.11.013
: https://doi.org/10.1016/j.jep.2013.11.013

32. The anti-tumor activity of Antrodia salmonea in human promyelocytic leukemia (HL-60) cells is mediated via the induction of G1 cell-cycle arrest and apoptosis in vitro or in vivo

Author:: You-Cheng Hseu; Chuan-Chen Lee; Yung-Chang Chen; K.J. Senthil Kumar; Chee-Shan Chen; Yu-Chi Huang; Li-Sung Hsu; Hui-Chi Huang; Hsin-Ling Yang
Source:: Journal of ethnopharmacology 2014 v.153 no.2 pp. 499-510
ISSN:: 0378-8741
Subject:: Antrodia; DNA fragmentation; Oriental traditional medicine; antineoplastic activity; antioxidants; apoptosis; caspase-3; cell cycle checkpoints; cell viability; culture media; cyclins; cytochrome c; death domain receptors; in vitro studies; leukemia; ligands; medicinal fungi; mice; mitochondria; mushrooms
Abstract:: ... The medicinal mushroom Antrodia salmonea has been used as a traditional Chinese medicine and has demonstrated antioxidant and anti-inflammatory effects.In the present study, we examined the anti-tumor activity of the fermented culture broth of Antrodia salmonea (AS) in vitro and in vivo and revealed its underlying molecular mechanism of action.Treatment of human promyelocytic leukemia (HL-60) cell ...
DOI:: 10.1016/j.jep.2014.03.012
: https://doi.org/10.1016/j.jep.2014.03.012

33. The forecast of anticancer targets of cryptotanshinone based on reverse pharmacophore-based screening technology

Author:: Dong-Ping YUAN; Jun LONG; Yin LU; Jie LIN; Li TONG
Source:: Chinese journal of natural medicines 2014 v.12 no.6 pp. 443-448
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; androgen receptors; angiogenesis; antineoplastic activity; apoptosis; cell cycle; databases; drugs; hepatoma; humans; mechanism of action; messenger RNA; screening; viability
Abstract:: ... Anticancer targets of cryptotanshinone were evaluated and rapidly forecasted with PharmMapper, a reverse pharmacophore-based screening platform, as well as drug target databases, including PDTD, DrugBank and TTD. The pathway analyses for the collection of anticancer targets screened were carried out based on the KEGG pathway database, followed by the forecast of potential pharmacological activitie ...
DOI:: 10.1016/S1875-5364(14)60069-8
: https://doi.org/10.1016/S1875-5364(14)60069-8

34. Angelica sinensis polysaccharides promotes apoptosis in human breast cancer cells via CREB-regulated caspase-3 activation

Author:: Wei-Jie Zhou; Sheng Wang; Zhuang Hu; Zhen-Yu Zhou; Cai-Juan Song
Source:: Biochemical and biophysical research communications 2015 v.467 pp. 562-569
ISSN:: 0006-291X
Subject:: 4',6-diamidino-2-phenylindole; Angelica sinensis; Oriental traditional medicine; adenosine monophosphate; antineoplastic activity; apoptosis; binding proteins; breast neoplasms; caspase-3; cyclic AMP; cytochrome c; cytosol; female genital diseases; flow cytometry; functional foods; humans; inflammation; membrane potential; mice; mitochondria; mitochondrial membrane; models; neoplasm cells; polysaccharides; protein synthesis; roots; signal transduction; staining
Abstract:: ... Angelica sinensis polysaccharide (ASP) is purified from the fresh roots of Angelica sinensis (AS). This traditional Chinese medicine has been used for thousands of years for treating gynecological diseases and used in functional foods for the prevention and treatment of various diseases, such as inflammation and cancer. The antitumor activity of ASP is related to its biological activities, because ...
DOI:: 10.1016/j.bbrc.2015.09.145
: https://doi.org/10.1016/j.bbrc.2015.09.145

35. Antitumor effect and apoptosis induction of Alocasia cucullata (Lour.) G. Don in human gastric cancer cells in vitro and in vivo

Author:: Peng Wei; Chen Zhiyu; Tang Xu; Zheng Xiangwei
Source:: BMC complementary and alternative medicine 2015 v.15 no.1 pp. 33
ISSN:: 1472-6882
Subject:: Alocasia; Oriental traditional medicine; Western blotting; alternative medicine; antineoplastic activity; apoptosis; cancer therapy; caspases; cell cycle; cell lines; chromatin; cyclins; cytochrome c; cytotoxicity; ethyl acetate; flow cytometry; gene expression; humans; inhibitory concentration 50; neoplasm cells; petroleum; protein synthesis; stomach neoplasms
Abstract:: ... BACKGROUND: Alocasia cucullata (Lour.) G. Don was applied in traditional Chinese medicine for the treatment of cancer in Chinese Southwest area. Its antitumor effect was scrutinized in vitro and in vivo. And for the first time, the mechanism of extract of A. cucullata (EAC) against human gastric cancer cell was well examined. METHODS: To detect the most effective fraction, the antiproliferation ef ...
DOI:: 10.1186/s12906-015-0554-2
: https://doi.org/10.1186/s12906-015-0554-2

36. Bioactive compounds from brown seaweeds: Phloroglucinol, fucoxanthin and fucoidan as promising therapeutic agents against breast cancer

Author:: D. Pádua; E. Rocha; D. Gargiulo; A.A. Ramos
Source:: Phytochemistry letters 2015 v.14 pp. 91-98
ISSN:: 1874-3900
Subject:: Oriental traditional medicine; Phaeophyceae; administered dose; angiogenesis; antineoplastic activity; antineoplastic agents; antioxidants; bioactive compounds; breast neoplasms; cell cycle checkpoints; cell death; chemoprevention; cytotoxicity; drug resistance; drug therapy; fucoidan; macroalgae; mechanism of action; metastasis; synergism; women
Abstract:: ... Breast cancer is one of the most common cancers among women and its incidence tends to increase year by year. Chemotherapy is an effective treatment for many types of cancer, however its toxicity in normal cells and acquired tumor resistance to the drug used are considered as the main barriers. New strategies have been proposed to increase the success of anticancer drugs namely it combination with ...
DOI:: 10.1016/j.phytol.2015.09.007
: https://doi.org/10.1016/j.phytol.2015.09.007

37. Bioactivity-guided isolation of anticancer constituents from Hedera nepalensis K. Koch

Author:: T. Li; H. Pan; Y. Feng; H. Li; Y. Zhao
Source:: South African journal of botany 2015 v.100 pp. 87-93
ISSN:: 0254-6299
Subject:: Hedera nepalensis; Oriental traditional medicine; antineoplastic activity; antineoplastic agents; apoptosis; cell growth; chromatography; death; dose response; growth retardation; humans; lung neoplasms; perennials; saponins; spectroscopy; China
Abstract:: ... Lung cancer is the number one cause of death among individuals with malignant tumors in China and the world, for which there is no cure. Hedera nepalensis K. Koch is a perennial plant widely used in traditional Chinese medicine. Its anticancer activity has been speculated, but not fully explored. In this study, we used bioactivity-guided isolation approaches to isolate anticancer constituents from ...
DOI:: 10.1016/j.sajb.2015.05.011
: https://doi.org/10.1016/j.sajb.2015.05.011

38. Carthami flos: a review of its ethnopharmacology, pharmacology and clinical applications

Author:: Yanhua Tu; Yingru Xue; Dandan Guo; Lianna Sun; Meili Guo
Source:: Revista Brasileira de Farmacognosia 2015 v.25 no.5 pp. 553-566
ISSN:: 0102-695X
Subject:: Carthamus tinctorius; Oriental traditional medicine; adverse effects; anti-inflammatory activity; antineoplastic activity; brain; coronary disease; diabetes mellitus; fatty liver; florets; glycemic effect; hypersensitivity; hypertension; nephrotoxicity; orthopedics; osteoblasts; protective effect; spermatogenesis; stroke; therapeutics; toxicology; China
Abstract:: ... Carthami flos, the dried floret of Carthamus tinctorius L., Asteraceae (safflower), has been widely used in traditional Chinese medicine to treat a broad range of ailments, such as coronary heart disease, angina pectoris, gynecologic disease, stroke, and hypertension. However, although several studies on Carthami flos have been done consecutively, the results are usually scattered across various d ...
DOI:: 10.1016/j.bjp.2015.06.001
: https://doi.org/10.1016/j.bjp.2015.06.001

39. Diversity, bioactivities, and metabolic potentials of endophytic actinomycetes isolated from traditional medicinal plants in Sichuan, China

Author:: Peng QIU; Zhi-Xiang FENG; Jie-Wei TIAN; Zu-Chao LEI; Lei WANG; Zhi-Gang ZENG; Yi-Wen CHU; Yong-Qiang TIAN
Source:: Chinese journal of natural medicines 2015 v.13 no.12 pp. 942-953
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Streptomyces; antibiotics; antineoplastic activity; biochemical pathways; biosynthesis; endophytes; genes; medicinal plants; models; pathogens; polymerase chain reaction; prediction; ribosomal RNA; screening; secondary metabolites; sequence analysis; species diversity; China
Abstract:: ... The present study was designed to determine the taxonomic diversity and metabolic activity of the actinomycetes community, including 13 traditional medicinal plants collected in Sichuan province, China, using multiple approaches such as morphological and molecular identification methods, bioactivity assays, and PCR screening for genes involved in antibiotics biosynthesis. 119 endophytic actinomyce ...
DOI:: 10.1016/S1875-5364(15)30102-3
: https://doi.org/10.1016/S1875-5364(15)30102-3

40. Identfication of new naphthalenones from Juglans mandshurica and evalution of their anticancer activities

Author:: Li-Na GUO; Rui ZHANG; Xue-Ying GUO; Tao CUI; Wei DONG; Jin-Hai HUO; Wei-Ming WANG
Source:: Chinese journal of natural medicines 2015 v.13 no.9 pp. 707-710
ISSN:: 1875-5364
Subject:: Juglans mandshurica; Oriental traditional medicine; antineoplastic activity; hulls; inhibitory concentration 50; stomach neoplasms; walnuts
Abstract:: ... Two new naphthalenone compounds were isolated from green walnut husks of Juglans mandshurica and their structures were identified as 4-butoxybutoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (1), 4-ethoxyethoxy-5,8-dihydroxy-3,4-dihydro-2H-naphthalen-1-one (2). Compounds 1 and 2 were named as Juglanstetralone A (1) and Juglanstetralone B (2). Compound 1 showed more significant anti-tumor activi ...
DOI:: 10.1016/S1875-5364(15)30070-4
: https://doi.org/10.1016/S1875-5364(15)30070-4

41. Improved anti-tumor activity and safety profile of a paclitaxel-loaded glycyrrhetinic acid-graft-hyaluronic acid conjugate as a synergistically targeted drug delivery system

Author:: Li ZHANG; Jian-Ping ZHOU; Jing YAO
Source:: Chinese journal of natural medicines 2015 v.13 no.12 pp. 915-924
ISSN:: 1875-5364
Subject:: human cell lines; freeze drying; intravenous injection; light scattering; drugs; neoplasms; antineoplastic activity; Oriental traditional medicine; models; pharmacodynamics; mice; tissues; neoplasm cells; hemolysis; paclitaxel; drug delivery systems; nanoparticles; adverse effects; apoptosis
Abstract:: ... The present study was designed to develop and evaluate glycyrrhetinic acid-graft-hyaluronic acid (HGA) conjugate for intravenous paclitaxel (PTX) delivery. Lyophilized PTX-loaded self-assembled HGA nanoparticles (PTX/HGAs) were prepared and characterized by dynamic light scattering measurements. Hemolysis test, intravenous irritation assessment, and in vitro and in vivo pharmacodynamic studies wer ...
DOI:: 10.1016/S1875-5364(15)30097-2
: https://doi.org/10.1016/S1875-5364(15)30097-2

42. Modulation of signal transduction pathways by natural compounds in cancer

Author:: Alok Ranjan; Neel M. Fofaria; Sung-Hoon Kim; Sanjay K. Srivastava
Source:: Chinese journal of natural medicines 2015 v.13 no.10 pp. 730-742
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; World Health Organization; antineoplastic activity; antineoplastic agents; apoptosis; bioactive compounds; cell cycle checkpoints; cell growth; cell proliferation; clinical trials; drug therapy; metastasis; mortality; neoplasms; phytopharmaceuticals; reactive oxygen species; signal transduction
Abstract:: ... Cancer is generally regarded as the result of abnormal growth of cells. According to World Health Organization, cancer is the leading cause of mortality worldwide. Mother nature provides a large source of bioactive compounds with excellent therapeutic efficacy. Numerous phytochemicals from nature have been investigated for anticancer properties. In this review article, we discuss several natural c ...
DOI:: 10.1016/S1875-5364(15)30073-X
: https://doi.org/10.1016/S1875-5364(15)30073-X

43. Oridonin induces apoptosis in uveal melanoma cells by upregulation of Bim and downregulation of Fatty Acid Synthase

Author:: Zhimin Gu; Xiaohui Wang; Ruo Qi; Lijuan Wei; Yinping Huo; Yu Ma; Lei Shi; Yongjie Chang; Gongquan Li; Lixiao Zhou
Source:: Biochemical and biophysical research communications 2015 v.457 pp. 187-193
ISSN:: 0006-291X
Subject:: Oriental traditional medicine; antineoplastic activity; antineoplastic agents; apoptosis; cell viability; fatty-acid synthase; humans; insulin; melanoma; patients; small interfering RNA; translation (genetics)
Abstract:: ... Oridonin is an orally available drug isolated from Traditional Chinese Medicine. Previous studies with oridonin have demonstrated broad-spectrum anticancer activity in a variety of cancer types. However, the effect of oridonin in uveal melanoma has not been addressed. In this study, we aimed to investigate whether oridonin elicited anticancer activity and its underlying mechanism in human uveal me ...
DOI:: 10.1016/j.bbrc.2014.12.086
: https://doi.org/10.1016/j.bbrc.2014.12.086

44. Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii

Author:: Chenrui Li; Qiang Li; Qibing Mei; Tingli Lu
Source:: Life sciences 2015 v.126 pp. 57-68
ISSN:: 0024-3205
Subject:: Epimedium; Oriental traditional medicine; antineoplastic activity; bioactive compounds; bones; drugs; icariin; ingredients; medicinal plants; moieties; neuroprotective effect; osteoporosis; pharmacokinetics; therapeutics; tissue engineering
Abstract:: ... Herba Epimedii is an important medicinal plant which has been used in various traditional Chinese formulations for thousands of years as well as in modern proprietary traditional Chinese medicine products. It has extensive clinical indications, especially for the treatment of sexual dysfunction and osteoporosis. There have been more than 260 chemical moieties identified in the genus Epimedium most ...
DOI:: 10.1016/j.lfs.2015.01.006
: https://doi.org/10.1016/j.lfs.2015.01.006

45. Polytrichum commune L.ex Hedw ethyl acetate extract-triggered perturbations in intracellular Ca2+ homeostasis regulates mitochondrial-dependent apoptosis

Author:: Wenjuan Yuan; Xiaoxia Cheng; Pan Wang; Yali Jia; Quanhong Liu; Wei Tang; Xiaobing Wang
Source:: Journal of ethnopharmacology 2015 v.172 pp. 410-420
ISSN:: 0378-8741
Subject:: Bryopsida; NAD ADP-ribosyltransferase; Oriental traditional medicine; Polytrichum; Western blotting; antineoplastic activity; apoptosis; calcium; caspase-3; cytochrome c; cytotoxicity; deformation; ethyl acetate; flavonoids; flow cytometry; fluorescence microscopes; high performance liquid chromatography; homeostasis; leukemia; membrane potential; mitochondria; mitochondrial membrane; mononuclear leukocytes; mosses and liverworts; neoplasm cells; plasma membrane; protein synthesis; scanning electron microscopy; spectroscopy
Abstract:: ... Polytrichum commune L.ex Hedw (PCLH), a moss of Bryopsida, has been used as a traditional Chinese medicine and shown to possess anticancer activities. Previous studies have indicated its anti-leukemia effect but the potential mechanisms have not been fully explained.The present study aimed to further investigate the efficacy of PCLH ethyl acetate fraction (PC-EEF) and the associated mechanisms in ...
DOI:: 10.1016/j.jep.2015.07.002
: https://doi.org/10.1016/j.jep.2015.07.002

46. Proteomic analysis of hepatocellular carcinoma HepG2 cells treated with platycodin D

Author:: Jin-Jian LU; De-Zhao LU; Yu-Fei CHEN; Ya-Ting DONG; Jun-Ren ZHANG; Ting LI; Zheng-Hai TANG; Zhen YANG
Source:: Chinese journal of natural medicines 2015 v.13 no.9 pp. 673-679
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Western blotting; antineoplastic activity; cell viability; desorption; gel electrophoresis; hepatoma; herbal medicines; human cell lines; matrix-assisted laser desorption-ionization mass spectrometry; mechanism of action; neoplasm cells; proteins; proteome; proteomics; triterpenoid saponins
Abstract:: ... Platycodin D (PD), a triterpenoid saponin isolated from Platycodonis Radix, is a famous Chinese herbal medicine that has been shown to have anti-proliferative effects in several cancer cell lines. The aim of this study was to determine the changes in cellular proteins after the treatment of hepatocellular carcinoma HepG2 cells with PD using proteomics approaches. The cell viability was determined ...
DOI:: 10.1016/S1875-5364(15)30065-0
: https://doi.org/10.1016/S1875-5364(15)30065-0

47. Proteomic and bioinformatic analyses of possible target-related proteins of gambogic acid in human breast carcinoma MDA-MB-231 cells

Author:: Dong LI; Xiao-Yi SONG; Qing-Xi Yue; Ya-Jun CUI; Miao LIU; Li-Xing FENG; Wan-Ying WU; Bao-Hong JIANG; Min YANG; Xiao-Bo QU; Xuan LIU; De-An GUO
Source:: Chinese journal of natural medicines 2015 v.13 no.1 pp. 41-51
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Western blotting; antineoplastic activity; antineoplastic agents; apoptosis; bioinformatics; breast neoplasms; cell cycle checkpoints; cell proliferation; clinical trials; cytokines; cytoskeleton; cytotoxicity; flow cytometry; humans; keratin; mechanism of action; metabolism; neoplasm cells; proteomics; two-dimensional gel electrophoresis; vimentin; China
Abstract:: ... Gambogic acid (GA) is an anticancer agent in phase ‖b clinical trial in China but its mechanism of action has not been fully clarified. The present study was designed to search the possible target-related proteins of GA in cancer cells using proteomic method and establish possible network using bioinformatic analysis. Cytotoxicity and anti-migration effects of GA in MDA-MB-231 cells were checked u ...
DOI:: 10.1016/S1875-5364(15)60005-X
: https://doi.org/10.1016/S1875-5364(15)60005-X

48. Salvia miltiorrhiza: Traditional medicinal uses, chemistry, and pharmacology

Author:: Chun-Yan SU; Qian-Liang MING; Khalid RAHMAN; Ting HAN; Lu-Ping QIN
Source:: Chinese journal of natural medicines 2015 v.13 no.3 pp. 163-182
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Salvia miltiorrhiza; adverse effects; antineoplastic activity; cerebrovascular disorders; chemical composition; coronary disease; diterpenoids; drug interactions; essential oils; hydrophilicity; medicinal plants; phenolic acids; quinones
Abstract:: ... Salvia miltiorrhiza Bunge (SM) is a very popular medicinal plant that has been extensively applied for many years to treat various diseases, especially coronary heart diseases and cerebrovascular diseases, either alone or in combination with other Chinese plant-based medicines. Although a large number of studies on SM have been performed, they are scattered across a variety of publications. The pr ...
DOI:: 10.1016/S1875-5364(15)30002-9
: https://doi.org/10.1016/S1875-5364(15)30002-9

49. An evaluation of the anti-angiogenic effect of the Korean medicinal formula “Sa-mi-yeon-geon-tang” in vitro and in ovo

Author:: Jin-Mu Yi; Ok-Sun Bang; No Soo Kim
Source:: BMC complementary and alternative medicine 2015 v.15 no.1 pp. 42
ISSN:: 1472-6882
Subject:: Oriental traditional medicine; Western blotting; alternative medicine; angiogenesis; antineoplastic activity; cell adhesion; cell proliferation; chorioallantoic membrane; drug therapy; extracellular matrix; non-specific protein-tyrosine kinase; phosphorylation; quantitative polymerase chain reaction; viability
Abstract:: ... BACKGROUND: Angiogenesis is a general hallmark of cancer; therefore, the inhibition of tumor-derived angiogenesis is considered to be an attractive target in the development of anti-cancer agents. Sa-mi-yeon-geon-tang (SMYGT), a decoction that consists of four natural medicinal products, has been traditionally prescribed in Oriental medicine to treat diverse diseases, including cancer. In the pres ...
DOI:: 10.1186/s12906-015-0573-z
: https://doi.org/10.1186/s12906-015-0573-z

50. A novel protein with anti-metastasis activity on 4T1 carcinoma from medicinal fungus Cordyceps militaris

Author:: Qing Yang; Yalin Yin; Guojun Yu; Yanxia Jin; Xiangdong Ye; Alok Shrestha; Wei Liu; Wenhui Yu; Hui Sun
Source:: International journal of biological macromolecules 2015 v.80 pp. 385-391
ISSN:: 0141-8130
Subject:: Cordyceps militaris; Oriental traditional medicine; animal models; antineoplastic activity; breast neoplasms; carcinoma; chromatography; circular dichroism spectroscopy; cytotoxicity; databases; fruiting bodies; immunomodulation; interleukin-1beta; interleukin-6; lung neoplasms; macrophages; medicinal fungi; messenger RNA; metastasis; mice; neoplasm cells; transcription (genetics); tumor necrosis factor-alpha
Abstract:: ... Cordyceps militaris is a famous fungus used in traditional Chinese medicine for nearly one thousand years. And its fruiting body is known to possess anticancer and immunomodulatory activities. This study describes the isolation, characterization, and test of antitumor activity of a C. militaris protein, called here as “C. militaris immunoregulatory protein” (CMIP). CMIP was purified through a thre ...
DOI:: 10.1016/j.ijbiomac.2015.06.050
: https://doi.org/10.1016/j.ijbiomac.2015.06.050

51. The resveratrol oligomers, cis- and trans-gnetin H, from Paeonia suffruticosa seeds inhibit the growth of several human cancer cell lines

Author:: Ying Gao; Chunnian He; Ran Ran; Dabing Zhang; Dawei Li; Pei-Gen Xiao; Elliot Altman
Source:: Journal of ethnopharmacology 2015 v.169 pp. 24-33
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Paeonia suffruticosa; animal models; anti-inflammatory agents; antineoplastic activity; apoptosis; breast neoplasms; breasts; caspases; cell cycle; chemoprevention; cytochrome c; cytotoxicity; drug therapy; epithelial cells; flow cytometry; fluorescence; human cell lines; lung neoplasms; lungs; membrane potential; mitochondria; mitochondrial membrane; neoplasm cells; osteosarcoma; permeability; resveratrol; screening; seeds; transcription factor NF-kappa B; viability assays
Abstract:: ... Paeonia suffruticosa Andrews (PSE) is a well-known Chinese medicine that has been widely used as an anti-tumor, anti-oxidative and anti-inflammatory agent. cis- and trans-gnetin H are two resveratrol oligomers isolated from the seeds of PSE. Although resveratrol is widely considered to be one of the most valuable natural chemopreventive agents and there are numerous studies on the antitumor activi ...
DOI:: 10.1016/j.jep.2015.03.074
: https://doi.org/10.1016/j.jep.2015.03.074

52. A review on phytochemistry and pharmacological activities of the processed lateral root of Aconitum carmichaelii Debeaux

Author:: Guohong Zhou; Liying Tang; Xidan Zhou; Ting Wang; Zhenzhen Kou; Zhuju Wang
Source:: Journal of ethnopharmacology 2015 v.160 pp. 173-193
ISSN:: 0378-8741
Subject:: Aconitum carmichaelii; Oriental traditional medicine; active ingredients; alkaloids; analgesics; anti-aging properties; antineoplastic activity; bioactive compounds; cardiovascular system; chemical constituents of plants; coronary disease; energy; heart failure; hypotension; immune system; kidneys; leaves; lipemic effect; myocardial infarction; roots; stems; toxicity; China; Japan; Korean Peninsula
Abstract:: ... The processed lateral root of Aconitum carmichaelii Debeaux (Ranunculaceae), an extensively used traditional Chinese medicine, is known as Fuzi in China (Chinese: 附子), “bushi” in Japan, “Kyeong-Po Buja” in Korea, Chinese aconite, monkshood or Chinese wolfsbane. It has been used to treat shock resulting from acute myocardial infarction, low blood pressure, coronary heart disease, chronic heart fail ...
DOI:: 10.1016/j.jep.2014.11.043
: https://doi.org/10.1016/j.jep.2014.11.043

53. Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress

Author:: Li-Xing FENG; Peng SUN; Tian MI; Miao LIU; Wang LIU; Si YAO; Yi-Min CAO; Xiao-Lu YU; Wan-Ying WU; Bao-Hong JIANG; Min YANG; De-An GUO; Xuan LIU
Source:: Chinese journal of natural medicines 2016 v.14 no.11 pp. 856-864
ISSN:: 1875-5364
Subject:: Arisaema; Oriental traditional medicine; agglutinins; antineoplastic activity; apoptosis; autophagy; caspase-3; caspase-9; cell cycle checkpoints; cytotoxicity; humans; hydrophobic interaction chromatography; inflammation; interphase; lung neoplasms; medicinal plants; neoplasm cells; organelles; patients; seizures; staining
Abstract:: ... Arisaema heterophyllum Blume is one of the three medicinal plants known as traditional Chinese medicine Rhizoma Arisaematis (RA). RA has been popularly used to treat patients with convulsions, inflammation, and cancer for a long time. However, the underlying mechanisms for RA effects are still unclear. The present study was designed to determine the cytotoxicity of agglutinin isolated from Arisema ...
DOI:: 10.1016/S1875-5364(16)30102-9
: https://doi.org/10.1016/S1875-5364(16)30102-9

54. Amentoflavone enhances osteogenesis of human mesenchymal stem cells through JNK and p38 MAPK pathways

Author:: Xuan Zha; Zhoumei Xu; Yuyu Liu; Liangliang Xu; Hongxin Huang; Jingjing Zhang; Liao Cui; Chenhui Zhou; Daohua Xu
Source:: Natural medicines 2016 v.70 no.3 pp. 634-644
ISSN:: 1340-3443
Subject:: Danio rerio; Ginkgo; Oriental traditional medicine; Selaginella tamariscina; Western blotting; alkaline phosphatase; antineoplastic activity; antioxidants; bone formation; gene expression regulation; humans; larvae; mineralization; mitogen-activated protein kinase; osteoblasts; signal transduction; stem cells; transcription factors
Abstract:: ... Amentoflavone is a bioflavonoid found in a variety of traditional Chinese medicines such as Gingko and Selaginella tamariscina. It has been reported that amentoflavone has anti-inflammatory, antioxidant, antiviral and anticancer effects. However, the effect of amentoflavone on osteogenic differentiation of human mesenchymal stem cells (hMSCs) has not been studied. In this study, we aim to explore ...
DOI:: 10.1007/s11418-016-0993-1
: https://doi.org/10.1007/s11418-016-0993-1

55. Biochemical synthesis of silver nanoprticles using filamentous fungi Penicillium decumbens (MTCC-2494) and its efficacy against A-549 lung cancer cell line

Author:: Shahnaz Majeed; Mohd Syafiq bin Abdullah; Gouri Kumar Dash; Mohammed Tahir Ansari; Anima Nanda
Source:: Chinese journal of natural medicines 2016 v.14 no.8 pp. 615-620
ISSN:: 1875-5364
Subject:: Fourier transform infrared spectroscopy; Oriental traditional medicine; Penicillium decumbens; absorption; amines; amoxicillin; antimicrobial properties; antineoplastic activity; atomic force microscopy; biomedical research; biosynthesis; carbenicillin; cefixime; color; cost effectiveness; fungi; human cell lines; humans; lung neoplasms; nanobiotechnology; nanomedicine; nanoparticles; nanosilver; neoplasm cells; ofloxacin; piperacillin; proteins; roughness; scanning electron microscopy; silver; sparfloxacin; spectral analysis; topology; toxicity; virulent strains; India
Abstract:: ... Biosynthesis of silver and other metallic nanoparticles is one of the emerging research area in the field of science and technology due to their potentiality, especially in the field of nano-biotechnology and biomedical sciences in order to develop nanomedicine. In our present study, Penicillium decumbens (MTCC-2494) was brought from Institute of Microbial Technology (IMTECH) Chandigarh and employ ...
DOI:: 10.1016/S1875-5364(16)30072-3
: https://doi.org/10.1016/S1875-5364(16)30072-3

56. Cantharis by photosynthetic bacteria biotransformation: Reduced toxicity and improved antitumor efficacy

Author:: Man Yu; Yue Zhao
Source:: Journal of ethnopharmacology 2016 v.186 pp. 151-158
ISSN:: 0378-8741
Subject:: Mylabris; Oriental traditional medicine; acute toxicity; antineoplastic activity; biotransformation; culture media; experimental design; growth curves; ingredients; kidneys; lethal dose 50; liquids; liver; mice; photosynthetic bacteria; toxicity testing
Abstract:: ... The blister beetle, also known as Mylabris cichorii, is not only widely used in clinical applications in Chinese anticancer medicine, but is also one of the main ingredients in a variety of traditional Chinese medicinal preparations with anticancer activity. However, the strong toxicity exhibited by this beetle species limits its clinical applicability, with the photosynthetic bacteria featuring a ...
DOI:: 10.1016/j.jep.2016.03.058
: https://doi.org/10.1016/j.jep.2016.03.058

57. Co-delivery of doxorubicin and the traditional Chinese medicine quercetin using biotin–PEG₂₀₀₀–DSPE modified liposomes for the treatment of multidrug resistant breast cancer

Author:: Jiulong Zhang; Yue Luo; Xiufeng Zhao; Xiaowei Li; Kexin Li; Dawei Chen; Mingxi Qiao; Haiyang Hu; Xiuli Zhao
Source:: RSC advances 2016 v.6 no.114 pp. 113173-113184
ISSN:: 2046-2069
Subject:: Oriental traditional medicine; P-glycoproteins; adenosine triphosphate; antineoplastic activity; apoptosis; breast neoplasms; cell lines; cytoplasm; cytotoxicity; doxorubicin; drug delivery systems; drug therapy; histology; multiple drug resistance; neoplasm cells; quercetin; toxicity testing
Abstract:: ... At present, multidrug resistance (MDR) in cancer therapy is an international problem, which is caused mostly by the overexpressed P-glycoprotein (P-gp) efflux pump. To address this issue and effectively deliver chemotherapeutic drugs to cancer cells, a liposomal drug delivery system (DOX/QUE BPL) has been designed for the co-delivery of the antitumor drug doxorubicin (DOX) and the traditional Chin ...
DOI:: 10.1039/c6ra24173e
: https://doi.org/10.1039/c6ra24173e

58. In vitro cytotoxicity and antimicrobial activity of Talaromyces flavus SP5 inhabited in the marine sediment of Southern Coast of India

Author:: Bibin G. Anand; C. K. Navin Thomas; S. Prakash
Source:: Chinese journal of natural medicines 2016 v.14 no.12 pp. 913-921
ISSN:: 1875-5364
Subject:: Aspergillus oryzae; Candida tropicalis; Escherichia coli; Oriental traditional medicine; Pseudomonas aeruginosa; Talaromyces flavus; Trichoderma; animal pathogens; antimicrobial properties; antineoplastic activity; antineoplastic agents; bioactive compounds; coasts; cytotoxicity; gas chromatography-mass spectrometry; lethal concentration 50; marine fungi; marine sediments; neoplasm cells; screening; solvents; India
Abstract:: ... Marine sediment samples were collected from the coastal areas of Southern India, particularly in Kanyakumari District. Twenty-eight different fungal strains were isolated. The screening of fungi from marine sediment was done to isolate a potent fungus that can produce bioactive compounds for biomedical applications. Only three strains viz Trichoderma gamsii SP4, Talaromyces flavus SP5 and Aspergil ...
DOI:: 10.1016/S1875-5364(17)30016-X
: https://doi.org/10.1016/S1875-5364(17)30016-X

59. Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism

Author:: Huanli Xu; Tao Yang; Xiaohui Liu; Ye Tian; Xiaoliang Chen; Ru Yuan; Shuonan Su; Xiukun Lin; Guanhua Du
Source:: Life sciences 2016 v.144 pp. 138-147
ISSN:: 0024-3205
Subject:: Oriental traditional medicine; Western blotting; antineoplastic activity; apoptosis; cell cycle; cell viability; combination drug therapy; enzymes; fluorouracil; growth retardation; hepatoma; humans; luteolin; messenger RNA; metabolism; neoplasm cells; staining; synergism
Abstract:: ... Some compounds derived from Chinese medicine have demonstrated great prospective roles in sensitization to chemotherapy. This study aimed to investigate the combination of luteolin and 5-fluorouracil on proliferations of hepatocellular carcinoma cells and the potential mechanisms.The antitumor effects of luteolin, 5-fluorouracil, and their combinations were detected by 3-(4,5-dimethylthiazol-2-yl) ...
DOI:: 10.1016/j.lfs.2015.12.002
: https://doi.org/10.1016/j.lfs.2015.12.002

60. Marsdenia tenacissima extract suppresses A549 cell migration through regulation of CCR5-CCL5 axis, Rho C, and phosphorylated FAK

Author:: Sen-Sen LIN; Fang-Fang LI; Li SUN; Wei FAN; Ming GU; Lu-Yong ZHANG; Song QIN; Sheng-Tao YUAN
Source:: Chinese journal of natural medicines 2016 v.14 no.3 pp. 203-209
ISSN:: 1875-5364
Subject:: CCR5 receptor; CCR9 receptor; CXCR4 receptor; Marsdenia tenacissima; Oriental traditional medicine; antineoplastic activity; asthma; cell movement; chemokine CCL5; cystitis; dose response; ligands; lung neoplasms; metastasis; neoplasm cells; pharyngitis; phosphorylation; pneumonia; protein content; secretion
Abstract:: ... Marsdenia tenacissima, a traditional Chinese medicine, is long been used to treat various diseases including asthma, cancer, trachitis, tonsillitis, pharyngitis, cystitis, and pneumonia. Although Marsdenia tenacissima has been demonstrated to have strong anti-tumor effects against primary tumors, its effect on cancer metastasis remains to be defined, and the molecular mechanism underlying the anti ...
DOI:: 10.1016/S1875-5364(16)30017-6
: https://doi.org/10.1016/S1875-5364(16)30017-6

61. New arbutin derivatives from the leaves of Heliciopsis lobata with cytotoxicity

Author:: Wei-Yan QI; Na OU; Xiao-Dong WU; Han-Mei XU
Source:: Chinese journal of natural medicines 2016 v.14 no.10 pp. 789-793
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; antineoplastic activity; chemical structure; cytotoxicity; inhibitory concentration 50; leaves; medicinal plants; spectral analysis
Abstract:: ... Heliciopsis lobata is a medicinal plant, which is exclusively used to treat tumor in Li folk region. Two new arbutin derivatives, 6’-((E)2-methoxy-5-hydroxycinnamoyl) arbutin (1) and 2’-((E)2, 5-dihydroxycinnamoyl) arbutin (2) along with five known compounds (3–7), were isolated from the leaves of Heliciopsis lobata. Their structures were elucidated on the basis of extensive spectroscopic interpre ...
DOI:: 10.1016/S1875-5364(16)30094-2
: https://doi.org/10.1016/S1875-5364(16)30094-2

62. Pharmacokinetic profiles of falcarindiol and oplopandiol in rats after oral administration of polyynes extract of Oplopanax elatus

Author:: Wei SUN; Yi-Sheng HE; Ling-Hui XU; Bi-Ying ZHANG; Lian-Wen QI; Jie YANG; Ping LI; Xiao-Dong WEN
Source:: Chinese journal of natural medicines 2016 v.14 no.9 pp. 714-720
ISSN:: 1875-5364
Subject:: Oplopanax; Oriental traditional medicine; antineoplastic activity; liquid-liquid extraction; monitoring; oral administration; pharmacokinetics; rats; spectrometers; spectroscopy
Abstract:: ... Polyynes, such as facarindiol (FAD) and oplopandiol (OPD), are responsible for anticancer activities of Oplopanax elatus (O. elatus). A novel approach to pharmacokinetics determination of the two natural polyynes in rats was developed and validated using a liquid chromatography-electrospray ionization-mass spectrometry (LC-MS) method. Biosamples were prepared by liquid-liquid extraction using ethy ...
DOI:: 10.1016/S1875-5364(16)30085-1
: https://doi.org/10.1016/S1875-5364(16)30085-1

63. Red ginseng and cancer treatment

Author:: Chong-Zhi WANG; Samantha ANDERSON; Wei DU; Tong-Chuan HE; Chun-Su YUAN
Source:: Chinese journal of natural medicines 2016 v.14 no.1 pp. 7-16
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Panax ginseng; Panax notoginseng; Panax quinquefolius; air drying; angiogenesis; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; chemical bonding; ginsenosides; herbal medicines; neoplasms; steaming; stereoselectivity; structure-activity relationships; sugars
Abstract:: ... The ginseng family, including Panax ginseng (Asian ginseng), Panax quinquefolius (American ginseng), and Panax notoginseng (notoginseng), is commonly used herbal medicine. White ginseng is prepared by air-drying after harvest, while red ginseng is prepared by a steaming or heating process. The anticancer activity of red ginseng is significantly increased, due to the production of active anticancer ...
DOI:: 10.3724/SP.J.1009.2016.00007
: https://doi.org/10.3724/SP.J.1009.2016.00007

64. Screening and quantification of anticancer compounds in traditional Chinese medicine by hollow fiber cell fishing and hollow fiber liquid/solid‐phase microextraction

Author:: Caiyun Wang; Shuang Hu; Xuan Chen; Xiaohong Bai
Source:: Journal of separation science 2016 v.39 no.10 pp. 1814-1824
ISSN:: 1615-9306
Subject:: Oriental traditional medicine; agitation; antineoplastic activity; apoptosis; binding sites; cell culture; cell membranes; curcumin; high performance liquid chromatography; microextraction; neoplasm cells; neoplasms; pH; phospholipase C; salt concentration; screening; solvents; survival rate; temperature
Abstract:: ... Hollow fiber cell fishing, based on HepG‐2, SKOV‐3, and ACHN cancer cells, and hollow fiber liquid/solid microextraction with HPLC were developed and introduced for researching the anticancer activity of Rhizoma Curcumae Longae, Radix Curcumae, and Rhizoma Curcumae. The structures of curcumin, demethoxycurcumin, and bisdemethoxycurcumin screened were identified and their contents were determined. ...
DOI:: 10.1002/jssc.201600103
: https://doi.org/10.1002/jssc.201600103

65. Structural characterization and in vitro antitumor activity of an acidic polysaccharide from Angelica sinensis (Oliv.) Diels

Author:: Yu Zhang; Tao Zhou; Hongjing Wang; Zheng Cui; Fang Cheng; Kai-ping Wang
Source:: Carbohydrate polymers 2016 v.147 pp. 401-408
ISSN:: 0144-8617
Subject:: Angelica sinensis; Oriental traditional medicine; antineoplastic activity; arabinose; branches; cytotoxicity; dose response; galactose; gel chromatography; glucose; glucuronic acid; human cell lines; molecular weight; polysaccharides; roots
Abstract:: ... A water-soluble polysaccharide extracted from the roots of Angelica sinensis (Oliv.) Diels, which is a traditional Chinese medicine herb, was fractioned and purified by Sephadex G-50 gel filtration chromatography. The structural characterization and antitumor activities of the purified polysaccharide fraction, named as ASP, were evaluated in the present study. ASP, which molecular weight was deter ...
DOI:: 10.1016/j.carbpol.2016.04.002
: https://doi.org/10.1016/j.carbpol.2016.04.002

66. Synthesis and cytotoxicity evaluation of 3-amino-2-hydroxypropoxyisoflavone derivatives

Author:: Jing-Jing TANG; Xiao-Ting GENG; Ya-Jing WANG; Tian-Yu ZHENG; Jin-Rong LU; Rong HU
Source:: Chinese journal of natural medicines 2016 v.14 no.6 pp. 462-472
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; chemoprevention; cytotoxicity; enzymes; gene expression regulation; human cell lines; humans; isoflavones; neoplasm cells; neoplasms; oxidative stress; protein content
Abstract:: ... Soy isoflavones exert a wide variety of biological activities, such as antioxidant, anti-inflammatory and anti-cancer properties. Nuclear factor erythroid 2-related factor 2 (Nrf2), a bZip transcription factor, plays a key role in soy isoflavones induced protection against oxidative stress and cancer. To obtain more effective isofavones, a series of 7,4′-bis-(3-amino-2-hydroxypropoxy), 7 or 4′-(3- ...
DOI:: 10.1016/S1875-5364(16)30044-9
: https://doi.org/10.1016/S1875-5364(16)30044-9

67. Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.) F.H. Chen: A review

Author:: Ting Wang; Rixin Guo; Guohong Zhou; Xidan Zhou; Zhenzhen Kou; Feng Sui; Chun Li; Liying Tang; Zhuju Wang
Source:: Journal of ethnopharmacology 2016 v.188 pp. 234-258
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Panax notoginseng; antineoplastic activity; cardiovascular diseases; cardiovascular system; databases; flavonoids; hemorrhage; herbal medicines; immune system; inflammation; pain; saponins; structure-activity relationships; therapeutics; toxicology; China
Abstract:: ... Panax notoginseng (Burk.) F.H. Chen is a widely used traditional Chinese medicine known as Sanqi or Tianqi in China. This plant, which is distributed primarily in the southwest of China, has wide-ranging pharmacological effects and can be used to treat cardiovascular diseases, pain, inflammation and trauma as well as internal and external bleeding due to injury.This paper provides up-to-date infor ...
DOI:: 10.1016/j.jep.2016.05.005
: https://doi.org/10.1016/j.jep.2016.05.005

68. Anti-proliferation activity of terpenoids isolated from Euphorbia kansui in human cancer cells and their structure-activity relationship

Author:: Jin-Jun HOU; Yao SHEN; Zhou YANG; Lin FANG; Lu-Ying CAI; Shuai YAO; Hua-Li LONG; Wan-Ying WU; De-An GUO
Source:: Chinese journal of natural medicines 2017 v.15 no.10 pp. 766-774
ISSN:: 1875-5364
Subject:: Euphorbia kansui; Oriental traditional medicine; antineoplastic activity; asthma; breast neoplasms; colorectal neoplasms; diterpenoids; edema; humans; inhibitory concentration 50; melanoma; neoplasm cells; staurosporine; structure-activity relationships; triterpenoids
Abstract:: ... Euphorbia kansui is a commonly used traditional Chinese medicine for the treatment of edema, pleural effusion, and asthma, etc. According to the previous researches, terpenoids in E. kansui possess various biological activities, e.g., anti-virus, anti-allergy, antitumor effects. In this work, twenty five terpenoids were isolated from E. kansui, including thirteen ingenane- and eight jatrophane-typ ...
DOI:: 10.1016/S1875-5364(17)30108-5
: https://doi.org/10.1016/S1875-5364(17)30108-5

69. Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways

Author:: Do Luong Huynh; Neelesh Sharma; Amit Kumar Singh; Simrinder Singh Sodhi; Jiao-Jiao ZHANG; Raj Kumar Mongre; Mrinmoy Ghosh; Nameun Kim; Yang Ho Park; Dong Kee Jeong
Source:: Chinese journal of natural medicines 2017 v.15 no.1 pp. 15-40
ISSN:: 1875-5364
Subject:: AMP-activated protein kinase; DNA; Oriental traditional medicine; Scutellaria baicalensis; adverse effects; antineoplastic activity; antioxidants; apoptosis; drug resistance; flavonoids; metastasis; neoplasms; non-specific serine/threonine protein kinase; pharmacokinetics; researchers; signal transduction; telomerase; therapeutics
Abstract:: ... Wogonin is a plant flavonoid compound extracted from Scutellaria baicalensis (Huang-Qin or Chinese skullcap) and has been studied thoroughly by many researchers till date for its anti-viral, anti-oxidant, anti-cancerous and neuro-protective properties. Numerous experiments conducted in vitro and in vivo have demonstrated wogonin's excellent tumor inhibitory properties. The anti-cancer mechanism of ...
DOI:: 10.1016/S1875-5364(17)30005-5
: https://doi.org/10.1016/S1875-5364(17)30005-5

70. Anti-tumor and chemosensitization effects of Cryptotanshinone extracted from Salvia miltiorrhiza Bge. on ovarian cancer cells in vitro

Author:: Guoqiang Jiang; Jia Liu; Baoyin Ren; Lin Zhang; Lawrence Owusu; Likun Liu; Jing Zhang; Yawei Tang; Weiling Li
Source:: Journal of ethnopharmacology 2017 v.205 pp. 33-40
ISSN:: 0378-8741
Subject:: DNA damage; Oriental traditional medicine; Salvia miltiorrhiza; Western blotting; antineoplastic activity; apoptosis; caspases; cell movement; cell viability; chemosensitization; cisplatin; dose response; drug therapy; flow cytometry; hypertension; immunocytochemistry; metastasis; neoplasm cells; ovarian neoplasms; proteins; roots; tissue repair
Abstract:: ... Cryptotanshinone, a natural compound isolated from the roots of Salvia miltiorrhiza Bge. (Danshen), is a commonly used traditional Chinese medicine to treat high blood pressure in some countries. It has been shown that Cryptotanshinone induces cancer cells apoptosis and impairs cell migration and invasion. However, the antiproliferation and chemosensitization effects of Cryptotanshinone on ovarian ...
DOI:: 10.1016/j.jep.2017.04.026
: https://doi.org/10.1016/j.jep.2017.04.026

71. Anti-tumor and immunomodulatory activities induced by an alkali-extracted polysaccharide BCAP-1 from Bupleurum chinense via NF-κB signaling pathway

Author:: Xiangfu Song; Ting Ren; Zhou Zheng; Tiancheng Lu; Zhicheng Wang; Fengguo Du; Haibin Tong
Source:: International journal of biological macromolecules 2017 v.95 pp. 357-362
ISSN:: 0141-8130
Subject:: Bupleurum; Oriental traditional medicine; agarose; antineoplastic activity; blood serum; cytotoxicity; ethanol; fractionation; immunomodulation; inducible nitric oxide synthase; macrophages; mice; neoplasm cells; nitric oxide; phosphorylation; sarcoma; secretion; signal transduction; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Bupleurum chinense is a well-known traditional Chinese medicine. Polysaccharides extracted from medical plants possess multiple healthy benefits. In the present study, an alkali-extracted polysaccharide (BCAP-1) was isolated from Bupleurum chinense, and evaluated its physicochemical features, anti-tumor activities and immunomodulatory effects. BCAP-1 was obtained by alkali-extraction, ethanol prec ...
DOI:: 10.1016/j.ijbiomac.2016.10.112
: https://doi.org/10.1016/j.ijbiomac.2016.10.112

72. Anticancer carbazole alkaloids and coumarins from Clausena plants: A review

Author:: Li HUANG; Zhe-Ling FENG; Yi-Tao WANG; Li-Gen LIN
Source:: Chinese journal of natural medicines 2017 v.15 no.12 pp. 881-888
ISSN:: 1875-5364
Subject:: Clausena; Oriental traditional medicine; adverse effects; alkaloids; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; chemical constituents of plants; coumarins; cytotoxicity; drug therapy; edible fruits; fruit products; neoplasms; vegetables
Abstract:: ... Pharmaceutical research has focused on the discovery and development of anticancer drugs. Clinical application of chemotherapy drugs is limited due to their severe side effects. In this regard, new naturally occurring anticancer drugs have gained increasing attention because of their potential effectiveness and safety. Fruits and vegetables are promising sources of anticancer remedy. Clausena (fam ...
DOI:: 10.1016/S1875-5364(18)30003-7
: https://doi.org/10.1016/S1875-5364(18)30003-7

73. Anticancer effects of cantharidin in A431 human skin cancer (Epidermoid carcinoma) cells in vitro and in vivo

Author:: Chi‐Chuan Li; Fu‐Shun Yu; Ming‐Jen Fan; Ya‐Yin Chen; Jin‐Cherng Lien; Yu‐Cheng Chou; Hsu‐Feng Lu; Nou‐Ying Tang; Shu‐Fen Peng; Wen‐Wen Huang; Jing‐Gung Chung
Source:: Environmental toxicology 2017 v.32 no.3 pp. 723-738
ISSN:: 1520-4081
Subject:: DNA; DNA fragmentation; Oriental traditional medicine; animal models; antineoplastic activity; antineoplastic agents; apoptosis; calcium; cantharidin; carcinoma; caspase-8; cell growth; cell viability; cyclins; cytochrome c; cytotoxicity; death domain receptors; enzyme activity; enzyme inhibitors; flow cytometry; gel electrophoresis; humans; in vivo studies; interphase; membrane potential; mice; mitochondrial membrane; skin (animal); skin neoplasms
Abstract:: ... Cantharidin (CTD), a potential anticancer agent of Traditional Chinese Medicine has cytotxic effects in different human cancer cell lines. The cytotoxic effects of CTD on A431 human skin cancer (epidermoid carcinoma) cells in vitro and in A431 cell xenograft mouse model were examined. In vitro, A431 human skin cell were treated with CTD for 24 and 48 h. Cell phase distribution, ROS production, Ca² ...
DOI:: 10.1002/tox.22273
: https://doi.org/10.1002/tox.22273

74. Anticancer efficacy of the ethyl acetate extract from the traditional Chinese medicine herb Celastrus orbiculatus against human gastric cancer

Author:: Haibo Wang; Lide Tao; Tengyang Ni; Hao Gu; Feng Jin; Xiaojun Dai; Jun Feng; Yanbing Ding; Weiming Xiao; Shiyu Guo; Tadashi Hisamitsu; Yayun Qian; Yanqing Liu
Source:: Journal of ethnopharmacology 2017 v.205 pp. 147-157
ISSN:: 0378-8741
Subject:: B-lymphocytes; Celastrus orbiculatus; Oriental traditional medicine; Western blotting; analgesics; antineoplastic activity; apoptosis; caspases; cell growth; cell viability; ethyl acetate; flow cytometry; humans; image analysis; medicinal plants; membrane potential; microstructure; mitochondria; mitochondrial membrane; neoplasm cells; phosphatidylinositol 3-kinase; proteins; rapamycin; staining; stomach neoplasms; transmission electron microscopy; China
Abstract:: ... The traditional Chinese medicine (TCM) herb Celastrus orbiculatus is an important folk medicinal plant in China that has been used as an anti-inflammatory, antitumor, and analgesic in various diseases. The ethyl acetate extract of C. orbiculatus (C. orbiculatus extract, COE) was reported to show significant antitumor effects. However, no study in China or abroad has reported the effect and mechani ...
DOI:: 10.1016/j.jep.2017.04.030
: https://doi.org/10.1016/j.jep.2017.04.030

75. Antiproliferative effect of Momordica cochinchinensis seeds on human lung cancer cells and isolation of the major constituents

Author:: Jae Sik Yu; Hyun-Soo Roh; Seul Lee; Kiwon Jung; Kwan-Hyuck Baek; Ki Hyun Kim
Source:: Revista Brasileira de Farmacognosia 2017 v.27 no.3 pp. 329-333
ISSN:: 0102-695X
Subject:: Momordica cochinchinensis; Oriental traditional medicine; anti-ulcer activity; antineoplastic activity; antioxidants; cell proliferation; edible fruits; endothelial cells; ethanol; humans; lung neoplasms; neoplasm cells; saponins; secondary metabolites; seeds; triterpenoids
Abstract:: ... Gac, Momordica cochinchinensis (Lour.) Spreng., Cucurbitaceae, is an indigenous South Asian edible fruit and has been used therapeutically in Traditional Chinese Medicine. Previous studies have shown that M. cochinchinensis seed (Momordicae Semen) has various pharmaceutical properties such as antioxidant and anti-ulcer effects as well as contains secondary metabolites with potential anticancer act ...
DOI:: 10.1016/j.bjp.2017.02.002
: https://doi.org/10.1016/j.bjp.2017.02.002

76. Antitumorpharmacological mechanism of the oral liquid of Poriacocos polysaccharide

Author:: Chunyu Shi; Qinhai Ma; Mengyue Ren; Dedong Liang; Qingtian Yu; Jiabo Luo
Source:: Journal of ethnopharmacology 2017 v.209 pp. 24-31
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Western blotting; Wolfiporia cocos; antineoplastic activity; apoptosis; caspase-3; caspase-9; fungi; immunohistochemistry; liver; mice; oral administration; polysaccharides; sarcoma; spleen; staining; thymus gland; tissues
Abstract:: ... The liquid oral formulation of Poria cocos polysaccharides is composed of polysaccharides of Lentinusedodes, Ganodermalucidum and Poria cocos(1:1:2), which are all fungi used in traditional Chinese medicine. Polysaccharides extracted from these fungi have been reported to exhibit an antitumor effect by modulating the immune system.The present study aimed to clarify the antitumor mechanism of an or ...
DOI:: 10.1016/j.jep.2017.07.003
: https://doi.org/10.1016/j.jep.2017.07.003

77. Apigenin's anticancer properties and molecular mechanisms of action: Recent advances and future prospectives

Author:: Jumah Masoud Mohammad SALMANI; Xiao-Ping ZHANG; Joe Antony JACOB; Bao-An CHEN
Source:: Chinese journal of natural medicines 2017 v.15 no.5 pp. 321-329
ISSN:: 1875-5364
Subject:: DNA damage; Oriental traditional medicine; antineoplastic activity; antioxidants; apigenin; apoptosis; autophagy; fruit products; mechanism of action; models; natural resources; neoplasms; risk; vegetables
Abstract:: ... Cancer is a major health concern and leading burden on economy worldwide. An increasing effort is devoted to isolation and development of plant-derived dietary components as effective chemo-preventive products. Phytochemical compounds from natural resources such as fruits and vegetables are responsible for decreasing the risk of certain cancers among the consuming populations. Apigenin, a flavonoi ...
DOI:: 10.1016/S1875-5364(17)30052-3
: https://doi.org/10.1016/S1875-5364(17)30052-3

78. Berberine inhibits the proliferation and migration of breast cancer ZR-75-30 cells by targeting Ephrin-B2

Author:: Weina Ma; Man Zhu; Dongdong Zhang; Liu Yang; Tianfeng Yang; Xin Li; Yanmin Zhang
Source:: Phytomedicine 2017 v.25 pp. 45-51
ISSN:: 0944-7113
Subject:: Coptis chinensis; Oriental traditional medicine; antineoplastic activity; berberine; binding proteins; breast neoplasms; cell growth; cell membranes; cell movement; cell proliferation; chromatography; phosphorylation; vascular endothelial growth factor receptor-2
Abstract:: ... Berberine, a plant-derived compound isolated from Coptis chinensis used in traditional Chinese medicine, has been shown to possess anti-cancer properties. However, no study has shown that berberine could target ephrin-B2, which plays a critical role in cell proliferation and migration.The aim of this study is to investigate the effect of berberine on cancer cell growth and migration, through the r ...
DOI:: 10.1016/j.phymed.2016.12.013
: https://doi.org/10.1016/j.phymed.2016.12.013

79. Biological characteristics, bioactive components and antineoplastic properties of sporoderm-broken spores from wild Cordyceps cicadae

Author:: Yanfang Sun; Michael Wink; Pan Wang; Hongfei Lu; Hongxin Zhao; Hongtao Liu; Shixian Wang; Yang Sun; Zongsuo Liang
Source:: Phytomedicine 2017 v.36 pp. 217-228
ISSN:: 0944-7113
Subject:: Cordyceps; Oriental traditional medicine; Paecilomyces; antineoplastic activity; apoptosis; beta catenin; bioactive compounds; cadherins; cell cycle; cordycepin; entomopathogenic fungi; fluorescent antibody technique; fluorescent dyes; gas chromatography-mass spectrometry; ingredients; inhibitory concentration 50; ions; lung neoplasms; neoplasm cells; nucleotide sequences; phylogeny; powders; ribosomal DNA; spores; staining; volatile compounds
Abstract:: ... Cordyceps cicadae, an entomogenous fungus has been used as a dietary therapeutic in traditional Chinese medicine for several millennia, in the form of powders and decoction. However, wild C. cicadae is notably scarce. To date, there is still a lack of comprehensive and deep studies on the biological characteristics, chemical profiles and antineoplastic mechanisms of C. cicadae, especially its spor ...
DOI:: 10.1016/j.phymed.2017.10.004
: https://doi.org/10.1016/j.phymed.2017.10.004

80. Cinobufagin, a bufadienolide, activates ROS-mediated pathways to trigger human lung cancer cell apoptosis in vivo

Author:: Panli Peng; Junhong Lv; Changqing Cai; Shaohuan Lin; Enqing Zhuo; Senming Wang
Source:: RSC advances 2017 v.7 no.40 pp. 25175-25181
ISSN:: 2046-2069
Subject:: Bufo bufo; Oriental traditional medicine; antineoplastic activity; apoptosis; bufadienolides; caspases; dose response; epithelial cells; humans; inhibitory concentration 50; lung neoplasms; mitochondria; neoplasm cells; phosphorylation; therapeutics; toads; venoms
Abstract:: ... Lung cancer, as the most common malignancy worldwide, is one of the most threatening diseases for human beings. Chan Su, an ethanolic extract from skin and parotid venom glands of the Bufo bufo gargarizans Cantor, is widely used as a traditional Chinese medicine in cancer therapy. Bufadienolides are cardiotonic steroids isolated from the skin and parotid venom glands of toad Bufo bufo gargarizans ...
DOI:: 10.1039/c7ra01085k
: https://doi.org/10.1039/c7ra01085k

81. Cordyceps militaris hot water extract inhibits lipopolysaccharide-induced inflammatory response in porcine alveolar macrophages by the regulation of mitogen-activated protein kinase signaling pathway

Author:: Felix Shih-Hsiang Hsiao; Yeong-Hsiang Cheng; Szu-Kai Wang; Yu-Hsiang Yu
Source:: Canadian journal of animal science 2017 v.98 no.1 pp. 44-52
ISSN:: 1918-1825
Subject:: Cordyceps militaris; Oriental traditional medicine; antineoplastic activity; bioactive compounds; cordycepin; dose response; feed additives; immunomodulation; immunomodulators; inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; macrophages; medicinal fungi; mitogen-activated protein kinase; nitric oxide; phosphorylation; prostaglandin synthase; protein synthesis; secondary metabolites; secretion; signal transduction; swine; tumor necrosis factor-alpha
Abstract:: ... Cordyceps militaris is a rare and exotic medicinal mushroom used in traditional Chinese medicine. The secondary metabolite, cordycepin (3′-deoxyadenosine), produced from C. militaris is a biologically active compound. Cordycepin has been demonstrated to exert several pharmacological effects, such as anti-microbial and anti-tumor activities. However, the effect of cordycepin on the immune modulatio ...
DOI:: 10.1139/cjas-2016-0244
: https://doi.org/10.1139/cjas-2016-0244

82. Curcumol Induces Cell Cycle Arrest in Colon Cancer Cells via Reactive Oxygen Species and Akt/ GSK3β/cyclin D1 Pathway

Author:: Juan Wang; Xu-mei Li; Zhun Bai; Bi-xia Chi; Yan Wei; Xu Chen
Source:: Journal of ethnopharmacology 2017 pp. -
ISSN:: 0378-8741
Subject:: Curcuma kwangsiensis; Oriental traditional medicine; Western blotting; acetylcysteine; antineoplastic activity; carcinogenesis; cell cycle checkpoints; cell growth; colorectal neoplasms; cyclin-dependent kinase; cyclins; ethanol; flow cytometry; gene expression; growth retardation; humans; interphase; medicinal plants; messenger RNA; mice; neoplasm cells; phosphatidylinositol 3-kinase; quantitative polymerase chain reaction; reactive oxygen species; reverse transcriptase polymerase chain reaction; sesquiterpenoids; tau-protein kinase; China
Abstract:: ... Curcuma kwangsiensis S. G. Lee & C. F. Liang (Guangxi ezhu, in Chinese) belongs to the Zingiberaceae family, has been used as a traditionally Chinese medicine nearly 2,000 year. Curcumol is one of the guaiane-type sesquiterpenoid hemiketal isolated from medicine plant Curcuma kwangsiensis S. G. Lee & C. F. Liang, which has been reported possesses anti-cancer effects. Our previous study found that ...
DOI:: 10.1016/j.jep.2017.06.037
: https://doi.org/10.1016/j.jep.2017.06.037

83. Dithiothreitol enhanced arsenic‐trioxide‐induced cell apoptosis in cultured oral cancer cells via mitochondrial dysfunction and endoplasmic reticulum stress

Author:: Chia‐Wen Tsai; Mei‐Due Yang; Te‐Chun Hsia; Wen‐Shin Chang; Chin‐Mu Hsu; Yi‐Hsien Hsieh; Jing‐Gung Chung; Da‐Tian Bau
Source:: Environmental toxicology 2017 v.32 no.1 pp. 17-27
ISSN:: 1520-4081
Subject:: Oriental traditional medicine; antineoplastic activity; apoptosis; arsenic; arsenic oxide; calpain; cytotoxicity; dithiothreitol; drinking; drugs; endoplasmic reticulum stress; hypertension; leukemia; liver; membrane potential; mitochondria; mouth neoplasms; neoplasm cells; neurotoxicity; patients; risk; therapeutics; tissue repair
Abstract:: ... Arsenic is naturally occurring toxic metalloid and drinking As₂O₃ containing water are recognized to be related to increased risk of neurotoxicity, liver injury, blackfoot disease, hypertension, and cancer. On the contrary, As₂O₃ has been an ancient drug used in traditional Chinese medicine with substantial anticancer activities, especially in the treatment of acute promyelocytic leukemia as well ...
DOI:: 10.1002/tox.22208
: https://doi.org/10.1002/tox.22208

84. Ethnopharmacology, phytochemistry, and pharmacology of Cornus officinalis Sieb. et Zucc

Author:: Jun Huang; Yiwei Zhang; Lin Dong; Qinghan Gao; Lei Yin; Hongfeng Quan; Rong Chen; Xueyan Fu; Dingbo Lin
Source:: Journal of ethnopharmacology 2017 pp. -
ISSN:: 0378-8741
Subject:: Cornus officinalis; Internet; Oriental traditional medicine; analgesic effect; analytical methods; anti-aging properties; antineoplastic activity; cardioprotective effect; chemical composition; chemical constituents of plants; drugs; fruits; glycemic effect; herbs; hypertension; immunomodulation; kidneys; knees; loganin; neuroprotective effect; organic acids and salts; pain; quality control; renoprotective effect; therapeutics; toxicology; waist; China
Abstract:: ... Cornus officinalis (Cornaceae), known in Chinese as “Shanzhuyu,” is a frequently used traditional Chinese medicine. It tastes sour and is astringent and slightly warm in nature. Its fruits have long been used to treat kidney deficiency, high blood pressure, waist and knee pain, dizziness, tinnitus, impotence, spermatorrhea, menorrhagia, and other diseases in China. The main distribution areas are ...
DOI:: 10.1016/j.jep.2017.11.010
: https://doi.org/10.1016/j.jep.2017.11.010

85. Evaluation of the anti-cancer activity of the triterpenoidal saponin fraction isolated from the traditional Chinese medicine Conyza blinii H. Lév.

Author:: Long Ma; Haiyan Liu; Lingpei Meng; Ping Qin; Botao Zhang; Yuyin Li; Shuli Man; Zhen Liu; Zhenxing Liu; Aipo Diao
Source:: RSC advances 2017 v.7 no.6 pp. 3408-3412
ISSN:: 2046-2069
Subject:: Conyza; Oriental traditional medicine; animal experimentation; antineoplastic activity; apoptosis; cell movement; dose response; flow cytometry; human cell lines; inflammation; interphase; medicinal plants; membrane potential; mitochondria; mitochondrial membrane; neoplasm cells; neoplasms; saponins; scanning electron microscopy; China
Abstract:: ... Conyza blinii H. Lév. is traditionally used in China as a medicinal plant to treat inflammation. We show here that the active fraction of this plant, Conyza blinii saponin (CBS), also has potent anti-cancer activity both in vitro and in vivo. Cell-based experiments showed that CBS suppresses the growth of cancer cells in a number of ways. CBS induces apoptosis in a dose-dependent manner. The mitoc ...
DOI:: 10.1039/c6ra26361e
: https://doi.org/10.1039/c6ra26361e

86. Ganoderma lucidum (Reishi) suppresses proliferation and migration of breast cancer cells via inhibiting Wnt/β-catenin signaling

Author:: Yu Zhang
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: Ganoderma lucidum; Oriental traditional medicine; antineoplastic activity; breast neoplasms; cell growth; cell movement; humans; mice; mushrooms; neoplasm cells; phosphorylation; signal transduction
Abstract:: ... The medical mushroom Ganoderma lucidum (Reishi), a traditional Chinese medicine, has exhibited a promising anti-cancer effect. However, the molecular mechanism of its action on cancer cells remains unclear. Aberrant activation of Wnt/β-catenin signaling pathway is the cause of many types of cancer, including breast cancer. Here we investigated the effect of Reishi on Wnt/β-catenin signaling pathwa ...
DOI:: 10.1016/j.bbrc.2017.04.086
: https://doi.org/10.1016/j.bbrc.2017.04.086

87. Ginkgo biloba exocarp extracts induces apoptosis in Lewis lung cancer cells involving MAPK signaling pathways

Author:: Chenjie Cao; Ya Su; Dongdong Han; Yanqi Gao; Menghua Zhang; Huasheng Chen; Aihua Xu
Source:: Journal of ethnopharmacology 2017 v.198 pp. 379-388
ISSN:: 0378-8741
Subject:: Ginkgo biloba; Oriental traditional medicine; Western blotting; antineoplastic activity; apoptosis; caspase-3; cyclophosphamide; cytosol; death; exocarp; growth retardation; in vitro studies; inhibitory concentration 50; lung neoplasms; membrane potential; messenger RNA; mice; mitochondria; mitochondrial membrane; mitogen-activated protein kinase; models; neoplasm cells; protein synthesis; proteins; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; China
Abstract:: ... A fruit of Ginkgo biloba L. is known as Ginkgo nuts. It is an edible traditional Chinese medicine, and could be used for the treatment of cancer thousands of years ago in China. The extracts prepared from the exocarp of Ginkgo biloba (Ginkgo biloba exocarp extracts, GBEE) has the effects of anti-cancer, immune promotion, anti-aging and etc.To study the effects of GBEE inducing apoptosis in Lewis l ...
DOI:: 10.1016/j.jep.2017.01.009
: https://doi.org/10.1016/j.jep.2017.01.009

88. Ginsenoside Rk1 suppresses pro-inflammatory responses in lipopolysaccharide-stimulated RAW264.7 cells by inhibiting the Jak2/Stat3 pathway

Author:: Qian YU; Ke-Wu ZENG; Xiao-Li MA; Yong JIANG; Peng-Fei TU; Xue-Mei WANG
Source:: Chinese journal of natural medicines 2017 v.15 no.10 pp. 751-757
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; Panax; Western blotting; anti-inflammatory activity; antineoplastic activity; enzyme-linked immunosorbent assay; inflammation; interleukin-1beta; macrophages; metabolism; nitric oxide; non-specific protein-tyrosine kinase; phosphorylation; reverse transcriptase polymerase chain reaction; saponins; signal transduction; transactivators; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... The saponin ginsenoside Rk1 is a major compound isolated from ginseng. Ginsenoside Rk1 has been reported to have anti-inflammatory and anti-tumor properties and to be involved in the regulation of metabolism. However, the effect and mechanism of anti-inflammatory action of ginsenoside Rk1 has not been fully clarified. We investigated whether ginsenoside Rk1 could suppress the inflammatory response ...
DOI:: 10.1016/S1875-5364(17)30106-1
: https://doi.org/10.1016/S1875-5364(17)30106-1

89. High temperature and UV-C treatments affect stilbenoid accumulation and related gene expression levels in Gnetum parvifolium

Author:: Nan Deng; Caixia Liu; Ermei Chang; Jing Ji; Xiamei Yao; Jianyun Yue; Igor V. Bartish; Lanzhen Chen; Zeping Jiang; Shengqing Shi
Source:: Electronic Journal of Biotechnology 2017 v.25 pp. 43-49
ISSN:: 0717-3458
Subject:: Gnetum; Oriental traditional medicine; antineoplastic activity; bioactive compounds; biochemical pathways; biosynthesis; biotechnology; gene expression; genes; resveratrol; roots; seedlings; stems; temperature; ultraviolet radiation
Abstract:: ... Gnetum parvifolium stems and roots have been used for a long time in traditional Chinese medicines. Stilbenes are bioactive compounds present in G. parvifolium plants, and they possess antioxidative and anticancer properties. However, little is known about the responses of G. parvifolium stilbene biosynthetic pathways to stress conditions. Therefore, we investigated stilbene biosynthesis, includin ...
DOI:: 10.1016/j.ejbt.2016.11.001
: https://doi.org/10.1016/j.ejbt.2016.11.001

90. Hypaconitine inhibits TGF-β1-induced epithelial–mesenchymal transition and suppresses adhesion, migration, and invasion of lung cancer A549 cells

Author:: Hai-Tao FENG; Wen-Wen ZHAO; Jin-Jian LU; Yi-Tao WANG; Xiu-Ping CHEN
Source:: Chinese journal of natural medicines 2017 v.15 no.6 pp. 427-435
ISSN:: 1875-5364
Subject:: Aconitum; IKappaB kinase; Oriental traditional medicine; Western blotting; adhesion; alkaloids; analgesics; antineoplastic activity; cadherins; cytotoxicity; fluorescent antibody technique; lung neoplasms; metastasis; microscopy; signal transduction; therapeutics; transcription factor NF-kappa B; transforming growth factor beta 1
Abstract:: ... Epithelial-mesenchymal transition (EMT) has been implicated in tumor invasion and metastasis and provides novel strategies for cancer therapy. Hypaconitine (HpA), a diester-diterpenoid alkaloid isolated from the root of the Aconitum species, exhibits anti-inflammatory, analgesic, and especially, cardiotoxic activities. Here, we reported the anti-metastatic potentials of HpA in transforming growth ...
DOI:: 10.1016/S1875-5364(17)30064-X
: https://doi.org/10.1016/S1875-5364(17)30064-X

91. Imperatorin suppresses proliferation and angiogenesis of human colon cancer cell by targeting HIF-1α via the mTOR/p70S6K/4E-BP1 and MAPK pathways

Author:: Chunliu Mi; Juan Ma; Ke Si Wang; Hong Xiang Zuo; Zhe Wang; Ming Yue Li; Lian Xun Piao; Guang Hua Xu; Xuezheng Li; Zhe Shan Quan; Xuejun Jin
Source:: Journal of ethnopharmacology 2017 v.203 pp. 27-38
ISSN:: 0378-8741
Subject:: Angelica dahurica; Oriental traditional medicine; Western blotting; angiogenesis; antineoplastic activity; colorectal neoplasms; flow cytometry; fluorescent antibody technique; genes; headache; humans; hypoxia-inducible factor 1; interphase; messenger RNA; migraine; mitogen-activated protein kinase; phosphorylation; protein synthesis; rapamycin; reverse transcriptase polymerase chain reaction; ribosomal proteins; vascular endothelial growth factors
Abstract:: ... Angelica dahurica is a commonly used traditional Chinese medicine to treat migraine headache, toothache and cancer. Imperatorin is an active natural furocoumarin component originating from Angelica dahurica and has been shown to exhibit multiple bioeffector functions, including anti-cancer activity. However, the mechanism by which imperatorin inhibits tumor growth is not fully understood.The aim o ...
DOI:: 10.1016/j.jep.2017.03.033
: https://doi.org/10.1016/j.jep.2017.03.033

92. Liposome encapsulation attenuated venenum bufonis induced vascular irritation in rabbit ear vein via regulating TLR/MAPK/NF-κB pathway

Author:: Qin Cao; Jianming Guo; Dawei Qian; Hongyue Ma; Yunru Peng; Erxin Shang; Buchang Zhao; Jinao Duan
Source:: RSC advances 2017 v.7 no.44 pp. 27431-27440
ISSN:: 2046-2069
Subject:: Astragalus membranaceus; Meloidae; Oriental traditional medicine; Panax; Toll-like receptor 2; Toll-like receptor 4; Western blotting; adverse effects; animal models; antineoplastic activity; blood serum; ears; encapsulation; histopathology; immunohistochemistry; inflammation; interleukin-10; interleukin-1beta; interleukin-6; intravenous injection; necrosis; neoplasms; rabbits; signal transduction; tumor necrosis factor-alpha
Abstract:: ... Delisheng injection (DLS), composed of venenum bufonis (VB), Chinese blister beetle (CB), red ginseng (RG) and Astragalus membranaceus (AM), is a Chinese medicine injection with good efficacy for the treatment of different types of cancers, while the side effects of DLS, such as vascular irritation and inflammation, restrict its wide clinical applications. Based on our previous study, VB is a main ...
DOI:: 10.1039/c7ra01820g
: https://doi.org/10.1039/c7ra01820g

93. Mesua ferrea stem bark extract induces apoptosis and inhibits metastasis in human colorectal carcinoma HCT 116 cells, through modulation of multiple cell signalling pathways

Author:: Muhammad Asif; Armaghan Shafaei; Aman Shah Abdul Majid; Mohammed Oday Ezzat; Saad S Dahham; Mohamed B. Khadeer Ahamed; Chern Ein Oon; Amin Malik Shah Abdul Majid
Source:: Chinese journal of natural medicines 2017 v.15 no.7 pp. 505-514
ISSN:: 1875-5364
Subject:: Mesua ferrea; Oriental traditional medicine; antineoplastic activity; antineoplastic agents; apoptosis; bark; betulinic acid; chemical constituents of plants; colorectal neoplasms; fluorescence; gas chromatography-mass spectrometry; high performance liquid chromatography; humans; hypoxia-inducible factor 1; in vitro studies; membrane potential; metastasis; mitochondrial membrane; shrinkage; signal transduction; transforming growth factor beta
Abstract:: ... Considering the great potential of natural products as anticancer agents, the present study was designed to explore the molecular mechanisms responsible for anticancer activities of Mesua ferrea stem bark extract against human colorectal carcinoma. Based on MTT assay results, bioactive sub-fraction (SF-3) was selected for further studies using HCT 116 cells. Repeated column chromatography resulted ...
DOI:: 10.1016/S1875-5364(17)30076-6
: https://doi.org/10.1016/S1875-5364(17)30076-6

94. Novel Beta-Tubulin-Immobilized Nanoparticles Affinity Material for Screening β-Tubulin Inhibitors from a Complex Mixture

Author:: Liu Qing-Shan; Deng Ran; Yan Qing-Fang; Cheng Lin; Luo Yongming; Li Keqin; Yin Xiaoying; Qin Xiaoyan
Source:: ACS Applied Materials & Interfaces 2017 v.9 no.7 pp. 5725-5732
ISSN:: 1944-8252
Subject:: Chloranthus; Oriental traditional medicine; active ingredients; adsorption; antineoplastic activity; antineoplastic agents; binding capacity; binding sites; chemical elements; dissociation; mechanism of action; microtubules; models; molecular dynamics; molecular imprinting; nanoparticles; paclitaxel; polymethylmethacrylate; screening; structure-activity relationships; tubulin
Abstract:: ... In order to efficiently screen and isolate β-tubulin inhibitors, β-tubulin was immobilized on core–shell PMMA/CS (poly(methyl methacrylate)/Chitosan) nanoparticles to produce a new type of immobilized affinity material named β-tubulin-immobilized nanoparticles (β-TIN). The selectivity and adsorption performance of β-TIN were characterized using various control drugs. The β-TIN, the paclitaxel mole ...
DOI:: 10.1021/acsami.6b13477
: https://doi.org/10.1021/acsami.6b13477

95. Pharmacokinetic studies of active triterpenoid saponins and the total secondary saponin from Anemone raddeana Regel

Author:: Dandan Zhang; Tianli Lei; Chongning Lv; Huimin Zhao; Haiyan Xu; Jincai Lu
Source:: Journal of chromatography 2017 v.1044-1045 pp. 54-62
ISSN:: 1570-0232
Subject:: Oriental traditional medicine; absorption; active ingredients; ammonium acetate; antineoplastic activity; chromatography; human cell lines; intestines; models; permeability; pharmacokinetics; phloridzin; rats; rhizomes; triterpenoid saponins
Abstract:: ... The rhizome of Anemone raddeana Regel, a Traditional Chinese Medicine (TCM) which has a robust history treating rheumatism and neuralgia. The total secondary saponin (TSS) from it has demonstrated antitumor activity. In this study, a rapid and validated LC–MS/MS method was developed to simultaneously determine the active compounds (Hederacolchiside A1 and Eleutheroside K). Analytes were separated ...
DOI:: 10.1016/j.jchromb.2017.01.003
: https://doi.org/10.1016/j.jchromb.2017.01.003

96. Polysaccharides from Epimedium koreanum Nakai with immunomodulatory activity and inhibitory effect on tumor growth in LLC-bearing mice

Author:: Chengcheng Wang; Liang Feng; Jiayan Su; Li Cui; Dan Liu; Jun Yan; Chuanlin Ding; Xiaobin Tan; Xiaobin Jia
Source:: Journal of ethnopharmacology 2017 v.207 pp. 8-18
ISSN:: 0378-8741
Subject:: CD4-positive T-lymphocytes; Epimedium koreanum; Fourier transform infrared spectroscopy; Oriental traditional medicine; antineoplastic activity; arabinose; chemical composition; cytokines; fructose; galactosamine; galactose; glucose; glucuronic acid; immunity; immunomodulators; interferon-gamma; macrophages; mannose; mice; neoplasm cells; neoplasms; polysaccharides; rhamnose; scanning electron microscopy; secretion; silver; China
Abstract:: ... Epimedium koreanum Nakai is documented as tonic herbal in China for over a thousand years and has the potential to enhance the body's immunity according to the theory of traditional Chinese medicine. Polysaccharides are one of the most important effective compounds in Epimedium koreanum Nakai. Accumulating evidence indicated polysaccharides derived from traditional Chinese medicine have potent imm ...
DOI:: 10.1016/j.jep.2017.06.014
: https://doi.org/10.1016/j.jep.2017.06.014

97. Saponin fraction isolated from Conyza blinii H.Lév. demonstrates strong anti-cancer activity that is due to its NF-κB inhibition

Author:: Long Ma; Haiyan Liu; Ping Qin; Chenxi Hu; Shuli Man; Yuyin Li; Zhen Liu; Zhenxing Liu; Aipo Diao
Source:: Biochemical and biophysical research communications 2017 v.483 pp. 779-785
ISSN:: 0006-291X
Subject:: Conyza; Oriental traditional medicine; adverse effects; animal models; antineoplastic activity; apoptosis; cyclins; dose response; gene expression; mitochondria; neoplasm cells; neoplasms; pro-apoptotic proteins; saponins; transcription factor NF-kappa B
Abstract:: ... CBS (Conyza blinii saponin) is the total triterpenoidal saponins of Conyza blinii H.Lév which is a type of traditional Chinese medicine (TCM). We have discovered that CBS has a profound cytostatic activity against a range of solid tumour cells in a time- and dose-dependent manner. We also confirm that the cytostatic activity of CBS originates from its apoptosis induction effect. Additionally, we u ...
DOI:: 10.1016/j.bbrc.2016.12.066
: https://doi.org/10.1016/j.bbrc.2016.12.066

98. Study on Antitumour Activity of Scutellarin and Its Metabolite Scutellarein by Combining Activity Screening, Target Tissue Distribution and Pharmacokinetics

Author:: Meiqin Feng; Yanhong Song; Jinxiao Wu; Xuan Chen; Xiaohong Bai; Yanqin Zhang
Source:: Chromatographia 2017 v.80 no.3 pp. 427-435
ISSN:: 0009-5893
Subject:: Oriental traditional medicine; antineoplastic activity; blood; cell growth; hepatoma; high performance liquid chromatography; human cell lines; humans; ingredients; intraperitoneal injection; kidneys; liquid-phase microextraction; liver; metabolites; nutrient solutions; pharmacokinetics; screening; survival rate; tissue distribution
Abstract:: ... Ingredients in traditional Chinese medicine (TCM) can be absorbed into blood and reach and maintain effective concentrations in the target organ, which is the premise of the ingredients taking effect in vivo. Hollow fibre cell fishing (HFCF) based on ACHN human renal tubular cells or HepG2 hepatoma cells using high-performance liquid chromatography with ultraviolet detection (HPLC/UV), coupled wit ...
DOI:: 10.1007/s10337-017-3260-z
: https://doi.org/10.1007/s10337-017-3260-z

99. Synthesis and anti-hepatocellular carcinoma activity of novel O2-vinyl diazeniumdiolate-based nitric oxide-releasing derivatives of oleanolic acid

Author:: Yu ZOU; Chang YAN; Jing-Chao LIU; Zhang-Jian HUANG; Jin-Yi XU; Jin-Pei ZHOU; Hui-Bin ZHANG; Yi-Hua ZHANG
Source:: Chinese journal of natural medicines 2017 v.15 no.12 pp. 928-937
ISSN:: 1875-5364
Subject:: Oriental traditional medicine; active ingredients; antineoplastic activity; aqueous solutions; carcinoma; hepatocytes; human cell lines; liver neoplasms; neoplasm cells; nitric oxide; oleanolic acid; solubility
Abstract:: ... Considering that high levels of nitric oxide (NO) exert anti-cancer effect and the derivatives of oleanolic acid (OA) have shown potent anti-cancer activity, new O²-vinyl diazeniumdiolate-based NO releasing derivatives (5a–l, 11a–l) of OA were designed, synthesized, and biologically evaluated in the present study. These derivatives could release different amounts of NO in liver cells. Among them, ...
DOI:: 10.1016/S1875-5364(18)30009-8
: https://doi.org/10.1016/S1875-5364(18)30009-8

100. Targeting selenium nanoparticles combined with baicalin to treat HBV-infected liver cancer

Author:: Xueyang Fang; Xianlin Wu; Chang'e Li; Binwei Zhou; Xiaoyin Chen; Tianfeng Chen; Fang Yang
Source:: RSC advances 2017 v.7 no.14 pp. 8178-8185
ISSN:: 2046-2069
Subject:: Hepatitis B virus; Oriental traditional medicine; antineoplastic activity; apoptosis; baicalin; biocompatibility; cell movement; endocytosis; folic acid; hydrophilicity; liver neoplasms; lysosomes; moieties; nanoparticles; neoplasm cells; particle size distribution; selenium; tissues; toxicity
Abstract:: ... As a traditional Chinese medicine, baicalin exhibits high antitumor activity towards hepatitis B virus (HBV)-infected liver cancer, but low toxicity towards normal tissues. However, the properties of baicalin, including its low hydrophilicity and poor biocompatibility, have limited its clinical application. Herein, in this study, we have designed and synthesized multifunctional selenium nanopartic ...
DOI:: 10.1039/c6ra28229f
: https://doi.org/10.1039/c6ra28229f

PubAg

Main content area

Limit your search

Text Availability

Journal

Publication Year

Subject

Search

266 Search Results

Search Results

1. Arsenic Trioxide Controls the Fate of the PML-RARα Oncoprotein by Directly Binding PML

2. The mechanisms of action of Tianhua on antitumor activity in lung cancer cells

3. Diversity of Pharmacological Properties in Chinese and European Medicinal Plants: Cytotoxicity, Antiviral and Antitrypanosomal Screening of 82 Herbal Drugs

4. Purification of a protein from coelomic fluid of the earthworm Eisenia foetida and evaluation of its hemolytic, antibacterial, and antitumor activities

5. Composition–activity relationship modeling to predict the antitumor activity for quality control of curcuminoids from Curcuma longa L. (turmeric)

6. Lignans extracted from Vitex negundo possess cytotoxic activity by G2/M phase cell cycle arrest and apoptosis induction

7. Scutellaria barbata D. Don extract synergizes the antitumor effects of low dose 5-fluorouracil through induction of apoptosis and metabolism

8. Anti-inflammatory effect of Phellinus linteus grown on germinated brown rice on dextran sodium sulfate-induced acute colitis in mice and LPS-activated macrophages

9. Anti-tumor and immunomodulatory activity of peptide fraction from the larvae of Musca domestica

10. Anticancer activity of Sargassum wightii Greville on Dalton's ascitic lymphoma

11. Chemical profiles and anticancer effects of saponin fractions of different polarity from the leaves of Panax notoginseng

12. Cyto-/genotoxic effects of the ethanol extract of Chan Su, a traditional Chinese medicine, in human cancer cell lines

13. DT-13, a saponin of dwarf lilyturf tuber, exhibits anti-cancer activity by down-regulating C-C chemokine receptor type 5 and vascular endothelial growth factor in MDA-MB-435 cells

14. Differentiation of bel-7402 human hepatocarcinoma cells induced by aqueous extracts of fresh gecko (AG) and its anti-tumor activity in vivo

15. Dynamic monitoring of the cytotoxic effects of protoberberine alkaloids from Rhizoma Coptidis on HepG2 cells using the xCELLigence system

16. Eupafolin, a skin whitening flavonoid isolated from Phyla nodiflora, downregulated melanogenesis: Role of MAPK and Akt pathways

17. Evaluation of the indicative roles of seven potential biomarkers on hepato-nephrotoxicity induced by Genkwa Flos

18. Hedyotis diffusa Willd extract inhibits the growth of human glioblastoma cells by inducing mitochondrial apoptosis via AKT/ERK pathways

19. Hypericin: chemical synthesis and biosynthesis

20. Inhibitory activities of Lignum Sappan extractives on growth and growth-related signaling of tumor cells

21. Lobelia chinensis: chemical constituents and anticancer activity perspective

22. Mechanism of action of (–)-epigallocatechin-3-gallate: auto-oxidation-dependent activation of extracellular signal-regulated kinase 1/2 in Jurkat cells

23. Oral JS-38, a metabolite from Xenorhabdus sp., has both anti-tumor activity and the ability to elevate peripheral neutrophils

24. Phenolcarboxylic acids from medicinal herbs exert anticancer effects through disruption of COX-2 activity

25. Preparation, characterization and cytotoxic activity of rhein argininate

26. Prescription patterns of Chinese herbal products for post-surgery colon cancer patients in Taiwan

27. Schisandra polysaccharide evokes immunomodulatory activity through TLR 4-mediated activation of macrophages

28. Sedum sarmentosum Bunge extract exerts renal anti-fibrotic effects in vivo and in vitro

29. Subchronic oral toxicity of evodia fruit powder in rats

30. Synthesis, characterization, and anti-cancer activity of emodin-Mn(II) metal complex

31. A UPLC–MS/MS method for in vivo and in vitro pharmacokinetic studies of psoralenoside, isopsoralenoside, psoralen and isopsoralen from Psoralea corylifolia extract

32. The anti-tumor activity of Antrodia salmonea in human promyelocytic leukemia (HL-60) cells is mediated via the induction of G1 cell-cycle arrest and apoptosis in vitro or in vivo

33. The forecast of anticancer targets of cryptotanshinone based on reverse pharmacophore-based screening technology

34. Angelica sinensis polysaccharides promotes apoptosis in human breast cancer cells via CREB-regulated caspase-3 activation

35. Antitumor effect and apoptosis induction of Alocasia cucullata (Lour.) G. Don in human gastric cancer cells in vitro and in vivo

36. Bioactive compounds from brown seaweeds: Phloroglucinol, fucoxanthin and fucoidan as promising therapeutic agents against breast cancer

37. Bioactivity-guided isolation of anticancer constituents from Hedera nepalensis K. Koch

38. Carthami flos: a review of its ethnopharmacology, pharmacology and clinical applications

39. Diversity, bioactivities, and metabolic potentials of endophytic actinomycetes isolated from traditional medicinal plants in Sichuan, China

40. Identfication of new naphthalenones from Juglans mandshurica and evalution of their anticancer activities

41. Improved anti-tumor activity and safety profile of a paclitaxel-loaded glycyrrhetinic acid-graft-hyaluronic acid conjugate as a synergistically targeted drug delivery system

42. Modulation of signal transduction pathways by natural compounds in cancer

43. Oridonin induces apoptosis in uveal melanoma cells by upregulation of Bim and downregulation of Fatty Acid Synthase

44. Pharmacological effects and pharmacokinetic properties of icariin, the major bioactive component in Herba Epimedii

45. Polytrichum commune L.ex Hedw ethyl acetate extract-triggered perturbations in intracellular Ca2+ homeostasis regulates mitochondrial-dependent apoptosis

46. Proteomic analysis of hepatocellular carcinoma HepG2 cells treated with platycodin D

47. Proteomic and bioinformatic analyses of possible target-related proteins of gambogic acid in human breast carcinoma MDA-MB-231 cells

48. Salvia miltiorrhiza: Traditional medicinal uses, chemistry, and pharmacology

49. An evaluation of the anti-angiogenic effect of the Korean medicinal formula “Sa-mi-yeon-geon-tang” in vitro and in ovo

50. A novel protein with anti-metastasis activity on 4T1 carcinoma from medicinal fungus Cordyceps militaris

51. The resveratrol oligomers, cis- and trans-gnetin H, from Paeonia suffruticosa seeds inhibit the growth of several human cancer cell lines

52. A review on phytochemistry and pharmacological activities of the processed lateral root of Aconitum carmichaelii Debeaux

53. Agglutinin isolated from Arisema heterophyllum Blume induces apoptosis and autophagy in A549 cells through inhibiting PI3K/Akt pathway and inducing ER stress

54. Amentoflavone enhances osteogenesis of human mesenchymal stem cells through JNK and p38 MAPK pathways

55. Biochemical synthesis of silver nanoprticles using filamentous fungi Penicillium decumbens (MTCC-2494) and its efficacy against A-549 lung cancer cell line

56. Cantharis by photosynthetic bacteria biotransformation: Reduced toxicity and improved antitumor efficacy

57. Co-delivery of doxorubicin and the traditional Chinese medicine quercetin using biotin–PEG₂₀₀₀–DSPE modified liposomes for the treatment of multidrug resistant breast cancer

58. In vitro cytotoxicity and antimicrobial activity of Talaromyces flavus SP5 inhabited in the marine sediment of Southern Coast of India

59. Luteolin synergizes the antitumor effects of 5-fluorouracil against human hepatocellular carcinoma cells through apoptosis induction and metabolism

60. Marsdenia tenacissima extract suppresses A549 cell migration through regulation of CCR5-CCL5 axis, Rho C, and phosphorylated FAK

61. New arbutin derivatives from the leaves of Heliciopsis lobata with cytotoxicity

62. Pharmacokinetic profiles of falcarindiol and oplopandiol in rats after oral administration of polyynes extract of Oplopanax elatus

63. Red ginseng and cancer treatment

64. Screening and quantification of anticancer compounds in traditional Chinese medicine by hollow fiber cell fishing and hollow fiber liquid/solid‐phase microextraction

65. Structural characterization and in vitro antitumor activity of an acidic polysaccharide from Angelica sinensis (Oliv.) Diels

66. Synthesis and cytotoxicity evaluation of 3-amino-2-hydroxypropoxyisoflavone derivatives

67. Traditional uses, botany, phytochemistry, pharmacology and toxicology of Panax notoginseng (Burk.) F.H. Chen: A review

68. Anti-proliferation activity of terpenoids isolated from Euphorbia kansui in human cancer cells and their structure-activity relationship

69. Anti-tumor activity of wogonin, an extract from Scutellaria baicalensis, through regulating different signaling pathways

70. Anti-tumor and chemosensitization effects of Cryptotanshinone extracted from Salvia miltiorrhiza Bge. on ovarian cancer cells in vitro