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You searched for: Subject Pleurotus eryngii Remove constraint Subject: Pleurotus eryngii Subject induced pluripotent stem cells Remove constraint Subject: induced pluripotent stem cells
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1. MicroRNA Replacing Oncogenic Klf4 and c-Myc for Generating iPS Cells via Cationized Pleurotus eryngii Polysaccharide-based Nanotransfection

Author:
Deng Wenwen; Cao Xia; Chen Jingjing; Zhang Zhijian; Yu Qingtong; Wang Yan; Shao Genbao; Zhou Jie; Gao Xiangdong; Yu Jiangnan; Xu Ximing
Source:
ACS Applied Materials & Interfaces 2015 v.7 no.34 pp. 18957-18966
ISSN:
1944-8252
Subject:
Pleurotus eryngii; genetic engineering; humans; induced pluripotent stem cells; medicine; microRNA; nanoparticles; particle size; physicochemical properties; plasmids; polysaccharides; transcription factors; umbilical cord
Abstract:
... Induced pluripotent stem cells (iPSCs), resulting from the forced expression of cocktails out of transcription factors, such as Oct4, Sox2, Klf4, and c-Myc (OSKM), has shown tremendous potential in regenerative medicine. Although rapid progress has been made recently in the generation of iPSCs, the safety and efficiency remain key issues for further application. In this work, microRNA 302-367 was ...
DOI:
10.1021/acsami.5b06768

2. Pleurotus eryngii Polysaccharide Promotes Pluripotent Reprogramming via Facilitating Epigenetic Modification

Author:
Wenwen Deng; Xia Cao; Yan Wang; Qingtong Yu; Zhijian Zhang; Rui Qu; Jingjing Chen; Genbao Shao; Xiangdong Gao; Ximing Xu; Jiangnan Yu
Source:
Journal of agricultural and food chemistry 2016 v.64 no.6 pp. 1264-1273
ISSN:
0021-8561
Subject:
Pleurotus eryngii; bioactive properties; calcium phosphates; endocytosis; epigenetics; genes; induced pluripotent stem cells; mushrooms; nanoparticles; nutritive value; plasmids; polysaccharides
Abstract:
... Pleurotus eryngii is a medicinal/edible mushroom with great nutritional value and bioactivity. Its polysaccharide has recently been developed into an effective gene vector via cationic modification. In the present study, cationized P. eryngii polysaccharide (CPS), hybridized with calcium phosphate (CP), was used to codeliver plasmids (Oct4, Sox2, Klf4, c-Myc) for generating induced pluripotent ste ...
DOI:
10.1021/acs.jafc.5b05661