Subject: Western blotting - PubAg Search Results

1. (−)-Epicatechin modulates the expression of myomiRs implicated in exercise response in mouse skeletal muscle

Author:: Carlos Palma-Flores; Paola B. Zárate-Segura; J. Manuel Hernández-Hernández; Sergio de los Santos; Andrea S. Tejeda-Gómez; Luis Javier Cano-Martínez; Patricia Canto; Jorge Omar Garcia-Rebollar; Ramón M. Coral-Vázquez
Source:: Gene 2023 v.849 pp. 146907
ISSN:: 0378-1119
Subject:: Western blotting; bioinformatics; exercise; genes; hypertrophy; mice; microRNA; muscle development; muscles; myogenin; signal transduction; skeletal muscle
Abstract:: ... The flavanol (−)-epicatechin has exercise-mimetic properties. Besides, several miRNAs play a role in modulating the adaptation of the muscle to different training protocols. However, notwithstanding all information, few studies aimed to determine if (−)-epicatechin can modify the expression of miRNAs related to skeletal muscle development and regeneration. Mice were treated for fifteen days by ora ...
DOI:: 10.1016/j.gene.2022.146907
: https://doi.org/10.1016/j.gene.2022.146907

2. 23-O-acetylshengmanol-3-O-α-L-arabinoside alleviates lipopolysaccharide-induced acute lung injury through inhibiting IκB/NF-κB and MAPK/AP-1 signaling pathways

Author:: Chunyan Chen; Lin Li; Xiaomei Liu; Deqin Zhang; Yang Liu; Yuhong Li
Source:: Journal of ethnopharmacology 2023 v.300 pp. 115725
ISSN:: 0378-8741
Subject:: Actaea cimicifuga; Oriental traditional medicine; Western blotting; blood serum; cytotoxicity; edema; enzyme-linked immunosorbent assay; eosin; fluorescent antibody technique; genes; glycosides; histopathology; interleukin-6; lipopolysaccharides; lung function; lungs; macrophages; models; nitric oxide; pharyngitis; phosphorylation; plethysmography; protein content; rhizomes; therapeutics; toxicity testing; triterpenoids
Abstract:: ... Cimicifuga foetida L. is a well-established traditional Chinese medicine with heat-clearing and detoxifying effects and has good therapeutic effect on oral mucosal ulcer and pharyngitis. The rhizome of this herb is rich in triterpenoid glycosides, including 23-O-acetylshengmanol-3-o-α-L-arabinoside (DA). Whether and how DA attenuates acute lung injury (ALI) are unclear. Accordingly, we focused on ...
DOI:: 10.1016/j.jep.2022.115725
: https://doi.org/10.1016/j.jep.2022.115725

3. Ammonia-induced oxidative stress triggered proinflammatory response and apoptosis in pig lungs

Author:: Daojie Li; Long Shen; Di Zhang; Xiaotong Wang; Qiankun Wang; Wenhao Qin; Yun Gao; Xiaoping Li
Source:: Journal of environmental sciences (China) 2023 v.126 pp. 683-696
ISSN:: 1001-0742
Subject:: DNA; Western blotting; ammonia; animal models; apoptosis; dose response; epithelium; genes; inflammation; lungs; metabolome; mineral fertilizers; oxidative phosphorylation; oxidative stress; protein synthesis; pyruvic acid; swine; toxicity; transcriptome; transmission electron microscopy; China
Abstract:: ... Ammonia, a common toxic gas, is not only one of the main causes of haze, but also can enter respiratory tract and directly affect the health of humans and animals. Pig was used as an animal model for exploring the molecular mechanism and dose effect of ammonia toxicity to lung. In this study, the apoptosis of type II alveolar epithelial cells was observed in high ammonia exposure group using trans ...
DOI:: 10.1016/j.jes.2022.05.005
: https://doi.org/10.1016/j.jes.2022.05.005

4. Anti-inflammatory and osteoprotective effects of Shi-Wei-Ru-Xiang pills on collagen-induced arthritis in rats via inhibiting MAPK and STAT3 pathways

Author:: Hui Xiong; Fengping Meng; Miao Luo; Weiwu Chen; Juan Tian; Lunju Chen; Yankun Ju; Zhinan Mei
Source:: Journal of ethnopharmacology 2023 v.300 pp. 115693
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Western blotting; animal models; apoptosis; blood serum; cartilage; chondrocytes; coculture; flow cytometry; inflammation; interleukin-6; phosphorylation; protein synthesis; rheumatoid arthritis
Abstract:: ... Shi-Wei-Ru-Xiang pills (SW) as a tradition Tibetan medicine has been clinically proved effective in rheumatoid arthritis (RA) treatment. However, the underlying mechanism of SW remains unclear. This study aimed to investigate the anti-arthritic effect of SW and its possible mechanisms of action. A CIA rat model in vivo, and IL-1β-stimulated synoviocytes or chondrocytes and a co-culture system (IL- ...
DOI:: 10.1016/j.jep.2022.115693
: https://doi.org/10.1016/j.jep.2022.115693

5. Atractylodes lancea and Magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating Sirt1 to inhibit p53-driven miR-221

Author:: Jie Yang; Zi-Xuan Wang; Lei Fang; Tu-Shuai Li; Zhi-Hong Liu; Ying Pan; Ling-Dong Kong
Source:: Journal of ethnopharmacology 2023 v.300 pp. 115688
ISSN:: 0378-8741
Subject:: Atractylodes lancea; Magnolia officinalis; Oriental traditional medicine; Western blotting; adiponectin receptors; agonists; animal models; diet; fluorescent antibody technique; fructose; humans; insulin; insulin resistance; kidneys; liquid chromatography; non-specific serine/threonine protein kinase; pharmacology; rats; tandem mass spectrometry; therapeutics; thermosensitivity
Abstract:: ... In traditional Chinese medicine, a long term of improper diet causes the Dampness and disturbs Zang-Fu's functions including Kidney deficiency. Atractylodes lancea (Atr) and Magnolia officinalis (Mag) as a famous herb pair are commonly used to transform Dampness, with kidney protection. To explore how Atr and Mag protected against insulin signaling impairment in glomerular podocytes induced by hig ...
DOI:: 10.1016/j.jep.2022.115688
: https://doi.org/10.1016/j.jep.2022.115688

6. Calcium pyruvate attenuates fat deposition by augmenting fatty acid oxidation and inhibiting glucose oxidation in juvenile large yellow croaker (Larimichthys crocea) consuming a high-fat diet

Author:: Yunqiang Zhang; Wencong Lai; Qiuchi Chen; Wei Fang; Kun Cui; Yuliang He; Xueshan Li; Kangsen Mai; Qinghui Ai
Source:: Aquaculture 2023 v.562 pp. 738778
ISSN:: 0044-8486
Subject:: AMP-activated protein kinase; Larimichthys crocea; Western blotting; acetyl-CoA carboxylase; alanine transaminase; antioxidant activity; aquaculture; aspartate transaminase; beta oxidation; blood glucose; calcium; carnitine palmitoyltransferase; catalase; citrates; diacylglycerol acyltransferase; dietary supplements; droplet size; fatty acid transport proteins; fatty-acid synthase; fish; gene expression; glucokinase; glucose; growth performance; hepatosomatic index; hexokinase; high density lipoprotein cholesterol; high fat diet; interleukin-1beta; juveniles; lipemic effect; lipogenesis; liver; low density lipoprotein cholesterol; malate dehydrogenase; muscles; obesity; oxidation; phosphofructokinases; prostaglandin synthase; protein synthesis; pyruvate dehydrogenase (lipoamide); pyruvate kinase; pyruvic acid; succinate dehydrogenase (quinone); triacylglycerol lipase; triacylglycerols; weight gain
Abstract:: ... Calcium pyruvate (CP), known as an energetic aid, has been shown to enhance lipid utilization and prevent obesity in mammals. However, very few studies were conducted to evaluate the potential implications of CP for aquatic animals. This study examined the role of CP on fat deposition in large yellow croaker by feeding fish with high-fat diets containing four levels of dietary CP (0, 0.375%, 0.75% ...
DOI:: 10.1016/j.aquaculture.2022.738778
: https://doi.org/10.1016/j.aquaculture.2022.738778

7. Celastrus orbiculatus Thunb. extract inhibits EMT and metastasis of gastric cancer by regulating actin cytoskeleton remodeling

Author:: Haibo Wang; YuanYuan Luo; Shiya Ou; Tengyang Ni; Zewen Chu; Xinyi Feng; Xiaojun Dai; Xiaochun Zhang; Yanqing Liu
Source:: Journal of ethnopharmacology 2023 v.301 pp. 115737
ISSN:: 0378-8741
Subject:: Celastrus orbiculatus; Oriental traditional medicine; Western blotting; actin; analgesics; animals; cell movement; medicinal plants; metalloproteinases; metastasis; microfilaments; neoplasm cells; protein degradation; regulatory proteins; stomach neoplasms; China
Abstract:: ... The traditional Chinese medicine herb Celastrus orbiculatus Thunb. is an important folk medicinal plant in China that has been used as an anti-inflammatory, antitumor, and analgesic in various diseases. Recent years, many studies have reported the significant effects of Celastrus orbiculatus Thunb. extract (COE) on gastric cancer. However, the specific mechanism by which COE regulates gastric canc ...
DOI:: 10.1016/j.jep.2022.115737
: https://doi.org/10.1016/j.jep.2022.115737

8. Core-shell SERS nanotags-based western blot

Author:: Bing Liu; Hanyu Tang; Qian Liu; Wenwen Wang; Haitao Li; Shiya Zheng; Fei Sun; Xiangwei Zhao
Source:: Talanta 2023 v.253 pp. 123888
ISSN:: 0039-9140
Subject:: Western blotting; colorimetry; detection limit; glyceraldehyde-3-phosphate dehydrogenase; nanoparticles
Abstract:: ... Western blot (WB) is the most commonly used scheme for protein identification in life science, but it still faces great challenges in the accurate quantitative detection of low-abundance proteins. Here, we proposed a novel surface-enhanced Raman scattering-based Western blot (SERS-WB) to solve this challenge. SERS nanotags were used as quantitative labels of proteins, which were composed of gold-s ...
DOI:: 10.1016/j.talanta.2022.123888
: https://doi.org/10.1016/j.talanta.2022.123888

9. Effects of breviscapine on cerebral ischemia-reperfusion injury and intestinal flora imbalance by regulating the TLR4/MyD88/NF-κB signaling pathway in rats

Author:: Hai-Dong Chen; Ming-Zhao Jiang; Ying-Ying Zhao; Xin Li; Hai Lan; Wan-Qi Yang; Yong Lai
Source:: Journal of ethnopharmacology 2023 v.300 pp. 115691
ISSN:: 0378-8741
Subject:: Erigeron breviscapus; Western blotting; active ingredients; animal models; blood serum; brain; dysbiosis; herbal medicines; infarction; intestinal microorganisms; intestines; ischemia; pain; paralysis; people; protective effect; rheumatoid arthritis; stroke; traditional medicine; China
Abstract:: ... The plant Erigeron breviscapus (Vant.) Hand.-Mazz.,a Chinese herbal medicine with multiple pharmacological effects and clinical applications, has been traditionally used in the treatment of paralysis caused by stroke and joint pain from rheumatism by the Yi minority people of Southwest China for generations.However, its mechanism involves many factors and has not been fully clarified. Taking intes ...
DOI:: 10.1016/j.jep.2022.115691
: https://doi.org/10.1016/j.jep.2022.115691

10. Hericium caput-medusae (Bull.:Fr.) Pers. fermentation concentrate polysaccharides improves intestinal bacteria by activating chloride channels and mucus secretion

Author:: Cong Zhao; Chang Sun; Jing Yuan; Ivan Steve Nguepi Tsopmejio; Yuting Li; Yu Jiang; Hui Song
Source:: Journal of ethnopharmacology 2023 v.300 pp. 115721
ISSN:: 0378-8741
Subject:: Enterobacter; Hericium; Lachnospiraceae; Ruminococcaceae; Staphylococcus; Western blotting; chlorides; cystic fibrosis transmembrane conductance regulator; digestive tract; drugs; edible fungi; fermentation; intestinal microorganisms; intestinal secretions; intestines; mechanism of action; mucus; polysaccharides; protective effect; protein synthesis; secretion; traditional medicine; China
Abstract:: ... As a traditional edible fungus in China and many other Asian countries, Hericium caput-medusae (Bull. Fr.) Pers. is widely used to improve the health of the gastrointestinal tract. For example, the drug “Weilexin Granules” is mainly composed of H. caput-medusae (Bull. Fr.) Pers. fermentation concentrate. However, the mechanism of action remains to be elucidated. The purpose of this study was to as ...
DOI:: 10.1016/j.jep.2022.115721
: https://doi.org/10.1016/j.jep.2022.115721

11. Interaction of Polycyclic Aromatic Hydrocarbon compounds in fish primary hepatocytes: From molecular mechanisms to genotoxic effects

Author:: Isabella Bramatti; Beatriz Matos; Neusa Figueiredo; Pedro Pousão-Ferreira; Vasco Branco; Marta Martins
Source:: Science of the total environment 2023 v.855 pp. 158783
ISSN:: 0048-9697
Subject:: DNA; DNA damage; Sparus aurata; Western blotting; carcinogenicity; cell viability; chemical structure; comet assay; environment; environmental assessment; fish; genes; genotoxicity; hepatocytes; metabolites; mutagens; phenanthrenes; protein synthesis; risk assessment
Abstract:: ... Polycyclic Aromatic Hydrocarbons (PAHs) are persistent pollutants normally found in the environment as complex mixtures. Although several individual PAHs are classified as mutagenic and carcinogenic pollutants, the interaction effects between compounds in a mixture may trigger different toxicological mechanisms and, consequently, yield different effects to organisms which are not accounted for in ...
DOI:: 10.1016/j.scitotenv.2022.158783
: https://doi.org/10.1016/j.scitotenv.2022.158783

12. Saffron essential oil ameliorates CUMS-induced depression-like behavior in mice via the MAPK-CREB1-BDNF signaling pathway

Author:: Ziwei Chen; Jinping Gu; Susu Lin; Zijin Xu; Hongyu Xu; Jiajing Zhao; Peishi Feng; Yi Tao; Suhong Chen; Ping Wang
Source:: Journal of ethnopharmacology 2023 v.300 pp. 115719
ISSN:: 0378-8741
Subject:: Crocus sativus; Oriental traditional medicine; Western blotting; antidepressants; anxiety; blood serum; breathing; calcium; dopamine; enzyme-linked immunosorbent assay; essential oils; fluoxetine; gas chromatography-mass spectrometry; hippocampus; histopathology; models; neurons; odors; pharmacology; saffron; serotonin; stigma; sucrose; synapse; tail suspension test; therapeutics
Abstract:: ... Saffron, the dried stigma of Crocus sativus L., has a long history of use in the treatment of depression in traditional Chinese medicine and Islamic medicine. The unique aroma of saffron, primarily derived from its volatile oil, has been widely used by folk to mitigate anxiety and depression via sniffing because the aroma of saffron has a pleasant and invigorating effect. Aim of the study: This st ...
DOI:: 10.1016/j.jep.2022.115719
: https://doi.org/10.1016/j.jep.2022.115719

13. Uncovering the effect and mechanism of Panax notoginseng saponins on metabolic syndrome by network pharmacology strategy

Author:: Yisa Wang; Peng Ma; Zijing Wang; Mingxia Sun; Biyu Hou; Tianshu Xu; Wenlan Li; Xiuying Yang; Guanhua Du; Tengfei Ji; Guifen Qiang
Source:: Journal of ethnopharmacology 2023 v.300 pp. 115680
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Panax notoginseng; Western blotting; adipocytes; adiposity; blood glucose; blood stasis; brown adipose tissue; computer simulation; drugs; energy; fatty liver; glucose; heat production; high fat diet; histopathology; insulin tolerance test; liver; metabolic diseases; metabolic syndrome; metabolism; obesity; pharmacology; protective effect; quantitative polymerase chain reaction; saponins; stomach; therapeutics; weight loss; white adipose tissue
Abstract:: ... Metabolic syndrome (MetS) is a cluster of disease centered on obesity, which is the result of stagnation of liver qi according to traditional Chinese medicine. Panax notoginseng is a traditional Chinese herbal medicine, entering liver and stomach meridians and dissipating blood stasis, in which panax notoginseng saponins (PNS) are the main active components. However, its effects and mechanism on m ...
DOI:: 10.1016/j.jep.2022.115680
: https://doi.org/10.1016/j.jep.2022.115680

14. Xianglian Pill attenuates ulcerative colitis through TLR4/MyD88/NF-κB signaling pathway

Author:: Yuxin Dai; Qiulu Lu; Peiyi Li; Junyu Zhu; Jiaxin Jiang; Tong Zhao; Yue Hu; Kang Ding; Min Zhao
Source:: Journal of ethnopharmacology 2023 v.300 pp. 115690
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Western blotting; blood serum; colon; dextran sulfate; enzyme activity; enzyme-linked immunosorbent assay; fluorescent antibody technique; histopathology; interleukin-18; interleukin-6; liquid chromatography; models; myeloperoxidase; necrosis; neoplasms; protein domains; quantitative polymerase chain reaction; salicylic acid; ubiquitination; ulcerative colitis
Abstract:: ... Xianglian Pill (XLP) is a classical Chinese medicine prescription applied for controlling ulcerative colitis (UC). Whereas, the underlying mechanism remains unclear. The present work was aimed to investigate the mechanism of XLP in dextran sulfate sodium (DSS)-induced UC via the Toll Like Receptor 4 (TLR4)/Myeloid Differentiation factor 88 (MyD88)/Nuclear Factor kappa-B (NF-κB) signaling in mice. ...
DOI:: 10.1016/j.jep.2022.115690
: https://doi.org/10.1016/j.jep.2022.115690

15. The crude extract from the flowers of Trollius chinensis Bunge exerts anti-influenza virus effects through modulation of the TLR3 signaling pathway

Author:: Yuxi Liang; Xiaoli Liu; Jingyan Hu; Songli Huang; Xin Ma; Xiaoyan Liu; Rufeng Wang; Xiuhua Hu
Source:: Journal of ethnopharmacology 2023 v.300 pp. 115743
ISSN:: 0378-8741
Subject:: Influenza A virus; Oriental traditional medicine; Trollius chinensis; Western blotting; blood; cytoplasm; epithelium; fluorescent antibody technique; lungs; nasal cavity; pharmacology; pharyngitis; pneumonia; spleen; therapeutics; viruses
Abstract:: ... The flowers of Trollius chinensis Bunge (Ranunculaceae) is a traditional Chinese medicine used to treat various inflammatory diseases, including upper respiratory infections, chronic tonsillitis, and pharyngitis. Recently, there has been growing research on the antiviral role of the flowers of T. chinensis Bunge. However, little is known about its anti-influenza virus effects and the underlying me ...
DOI:: 10.1016/j.jep.2022.115743
: https://doi.org/10.1016/j.jep.2022.115743

16. The regulatory roles of DDIT4 in TDCIPP-induced autophagy and apoptosis in PC12 cells

Author:: Li Li; Lingyi Xi; Jin Wu; Zunquan Zhao; Youliang Chen; Weili Liu; Zhihui Pan; Mingzhu Liu; Danfeng Yang; Zhaoli Chen; Yanjun Fang
Source:: Journal of environmental sciences (China) 2023 v.125 pp. 823-830
ISSN:: 1001-0742
Subject:: DNA; Western blotting; apoptosis; autophagy; flame retardants; flow cytometry; humans; neurons; neurotoxicity; phosphates; phosphorylation; protective effect; rats; China
Abstract:: ... Tris (1,3-dichloro-2-propyl) phosphate (TDCIPP) is a commonly used organophosphate-based flame retardant and can bio-accumulate in human tissues and organs. As its structure is similar to that of neurotoxic organophosphate pesticides, the neurotoxicity of TDCIPP has raised widespread concerns. TDCIPP can increase neuronal apoptosis and induce autophagy. However, its regulatory mechanism remains un ...
DOI:: 10.1016/j.jes.2022.02.046
: https://doi.org/10.1016/j.jes.2022.02.046

17. (-) - Epicatechin improves Tibialis anterior muscle repair in CD1 mice with BaCl2-induced damage

Author:: Magally Ramírez-Ramírez; Francisca Fernández-Valverde; Andrea Reséndiz-García; Mirna G Martínez-Damas; Luis Javier Cano-Martínez; Alejandro Zentella-Dehesa; Ramón M Coral-Vázquez
Source:: Journal of nutritional biochemistry 2022 v.107 pp. 109069
ISSN:: 0955-2863
Subject:: Western blotting; animal models; antioxidants; diabetes; epicatechin; histology; hypertrophy; mice; muscle development; muscles; muscular dystrophy; myogenin; sarcopenia; skeletal muscle; therapeutics
Abstract:: ... Several studies have shown the beneficial effect that Epicatechin (Epi) has on the skeletal muscle of murine models and patients with muscular dystrophy and in the muscles of patients with diabetes or murine sarcopenia models. This flavanol has been shown to enhance antioxidant pathways and improve muscle architecture. However, the repair process during muscle regeneration has not been analyzed. T ...
DOI:: 10.1016/j.jnutbio.2022.109069
: https://doi.org/10.1016/j.jnutbio.2022.109069

18. (±)-Equol interferes with the secretion of gonadotropin-releasing hormone and the expression of neuromodulators in murine neurons

Author:: Jingyuan Xiong; Minghui Wang; Ye Tian; Aru Ling; Shufang Shan; Li Zhao; Guo Cheng
Source:: Toxicological and environmental chemistry 2022 v.104 no.1 pp. 129-140
ISSN:: 1029-0486
Subject:: RING finger domains; Western blotting; cell viability; daidzein; environmental science; enzyme-linked immunosorbent assay; estrogens; females; gonadotropin-releasing hormone; intestines; menopause; metabolites; mice; neurotransmitters; quantitative polymerase chain reaction; secretion; toxicology
Abstract:: ... S-Equol is an intestinal bacterial metabolite of the isoflavone daidzein. Racemic (±)-equol is used as a dietary estrogen supplement in menopausal women and is suggested to affect the female reproductive function and development, primarily controlled by the hypothalamic-pituitary-gonadal axis and gonadotropin-releasing hormone release. In this study, murine neurons were utilized to evaluate the ef ...
DOI:: 10.1080/02772248.2022.2055031
: https://doi.org/10.1080/02772248.2022.2055031

19. (−)-Agelasidine A Induces Endoplasmic Reticulum Stress-Dependent Apoptosis in Human Hepatocellular Carcinoma

Author:: I-Ta Lu; Shih-Chao Lin; Yi-Chia Chu; Ya Wen; You-Cheng Lin; Wen-Chien Cheng; Jyh-Horng Sheu; Chi-Chien Lin
Source:: Marine drugs 2022 v.20 no.2 pp. -
ISSN:: 1660-3397
Subject:: Western blotting; antibacterial properties; apoptosis; caspases; cell viability; death domain receptors; endoplasmic reticulum; guanidines; hepatoma; humans; liver; membrane potential; methanol; mitochondria; mitochondrial membrane; sesquiterpenoids
Abstract:: ... Liver cancers, such as hepatocellular carcinoma (HCC), are a highly prevalent cause of cancer-related deaths. Current treatments to combat liver cancer are limited. (−)-Agelasidine A, a compound isolated from the methanol extract of Agelasnakamurai, a sesquiterpene guanidine derived from sea sponge, has antibacterial activity. We demonstrated its anticancer capabilities by researching the associat ...
DOI:: 10.3390/md20020109
: https://doi.org/10.3390/md20020109

20. 13,13a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity

Author:: Gui-Yang Xia; Dong-Jie Fang; Ling-Yan Wang; Huan Xia; Ya-Nan Wang; Hong-Cai Shang; Sheng Lin
Source:: Phytochemistry 2022 v.194 pp. 113023
ISSN:: 0031-9422
Subject:: Corydalis yanhusuo; Western blotting; active sites; anti-inflammatory activity; bioassays; enantiomers; inducible nitric oxide synthase; interleukin-6; lipopolysaccharides; molecular dynamics; nitric oxide; plant biochemistry; skeleton; spectral analysis; transcription factor NF-kappa B
Abstract:: ... Six undescribed protoberberine derivatives including two pairs of enantiomers, named yanhusanines G-L, along with fifteen reported protoberberine alkaloids, were isolated from the tubers of Corydalis yanhusuo. Among them, yanhusanines H-L feature a unique 13,13a-seco skeleton which is rare in nature. Their structural elucidations were achieved by extensive spectroscopic analysis and quantum chemis ...
DOI:: 10.1016/j.phytochem.2021.113023
: https://doi.org/10.1016/j.phytochem.2021.113023

21. 17β-estradiol modulates the expression of hormonal receptors on THP-1 T. gondii-infected macrophages and monocytes in an AKT and ERK-dependent manner

Author:: Ana Laura Pereira-Suárez; María de la Luz Galván-Ramírez; Laura Rocío Rodríguez-Pérez; Edgar I. López-Pulido; Christian David Hernández-Silva; Inocencia Guadalupe Ramírez-López; Grecia Viridiana Morales Amaya; Luis David Lopez Cabrera; José Francisco Muñoz-Valle; Adrián Ramírez-de-Arellano
Source:: Molecular and biochemical parasitology 2022 v.247 pp. 111433
ISSN:: 0166-6851
Subject:: Toxoplasma gondii; Western blotting; cell growth; estrogen receptors; inflammation; macrophages; models; monocytes; parasites; parasitology; phosphatidylinositol 3-kinase; pregnancy; prolactin receptors; tachyzoites
Abstract:: ... Toxoplasma gondii (T. gondii) is a parasite common in pregnancy. Monocytes and macrophages are a significant immunologic barrier against T. gondii by boosting up inflammation. This outcome is highly regulated by signaling pathways such as MAPK (ERK1/2) and PI3K (AKT), necessary in cell growth and proliferation. It may be associated with the hormonal receptors’ modulation by T. gondii (Estrogen Rec ...
DOI:: 10.1016/j.molbiopara.2021.111433
: https://doi.org/10.1016/j.molbiopara.2021.111433

22. 17β-estradiol reduces NF-κB expression induced by increased crosstalk between KLF5 and ERα in murine vascular smooth muscle cells

Author:: Man-li Zhang; Man-na Zhang; Wen-li Wang; Hui Chen; Xia Wang; Xuan Li; Li Li; Fei Tong
Source:: Biochemical and biophysical research communications 2022 v.625 pp. 181-187
ISSN:: 0006-291X
Subject:: Western blotting; cardiovascular system; cell proliferation; chromatin immunoprecipitation; fluorescent antibody technique; inflammation; luciferase; research; smooth muscle
Abstract:: ... Pathological vascular remodeling and cell proliferation play vital roles in many proliferative vascular diseases. Estrogen can protect the cardiovascular system, but its exact molecular mechanism is unknown. Here we report that 17β-estradiol (E2) suppressed vascular smooth muscle cells (VSMCs) proliferation and inflammation. qRT-PCR and Western blot demonstrated that E2 decreased NF-κB p50 express ...
DOI:: 10.1016/j.bbrc.2022.07.054
: https://doi.org/10.1016/j.bbrc.2022.07.054

23. 18β-Glycyrrhetinic acid altered the intestinal permeability in the human Caco-2 monolayer cell model

Author:: Mojtaba Malekinejad; Mohammad Reza Pashaee; Hassan Malekinejad
Source:: European journal of nutrition 2022 v.61 no.7 pp. 3437-3447
ISSN:: 1436-6207
Subject:: Western blotting; absorption; adhesion; biochemical pathways; cell viability; cytotoxicity; dietary supplements; electrical resistance; epithelium; glycyrrhizin; human cell lines; humans; intestines; luciferase; metabolites; models; occludins; permeability; protein content; tight junctions; toxicity testing; traditional medicine
Abstract:: ... PURPOSE: Glycyrrhizin (GL) and its metabolites 18α-glycyrrhetinic acid (18α-GA) and 18β-glycyrrhetinic acid (18β-GA) are used as traditional medicine and food sweeteners. As the major rout of their administration is oral way, therefore their impact on intestinal epithelial cells are investigated. METHODS: The effects of GL and its metabolites on cell viability using MTT assay, on cytotoxicity usin ...
DOI:: 10.1007/s00394-022-02900-4
: https://doi.org/10.1007/s00394-022-02900-4

24. 2-Methoxyestradiol TPGS Micelles Attenuate Cyclosporine A-Induced Nephrotoxicity in Rats through Inhibition of TGF-β1 and p-ERK1/2 Axis

Author:: Mohammed W. Al-Rabia; Mohamed A. Alfaleh; Hani Z. Asfour; Waleed S. Alharbi; Mohamed A. El-Moselhy; Nabil A. Alhakamy; Usama A. Fahmy; Osama A. A. Ahmed; Omar Fahmy; Omar M. Rashad; Abdulmohsin J. Alamoudi; Ashraf B. Abdel-Naim
Source:: Antioxidants 2022 v.11 no.8 pp. -
ISSN:: 2076-3921
Subject:: Western blotting; antioxidants; bioavailability; cyclosporine; kidneys; males; micelles; nanocarriers; nephrotoxicity; oral administration; particle size; polyethylene glycol; protein synthesis; succinic acid
Abstract:: ... The immunosuppressant cyclosporine A (CSA) has been linked to serious renal toxic effects. Although 2-methoxyestradiol (2ME) possesses a wide range of pharmacological abilities, it suffers poor bioavailability after oral administration. The purpose of this study was to evaluate the potential of 2ME loaded D-ɑ-tocopheryl polyethylene glycol succinate (TPGS) micelles to prevent CSA-induced nephrotox ...
DOI:: 10.3390/antiox11081499
: https://doi.org/10.3390/antiox11081499

25. 20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo

Author:: Haibo Zhang; Jun-Koo Yi; Hai Huang; Sijun Park; Wookbong Kwon; Eungyung Kim; Soyoung Jang; Si-Yong Kim; Seong-kyoon Choi; Duhak Yoon; Sung-Hyun Kim; Kangdong Liu; Zigang Dong; Zae Young Ryoo; Myoung Ok Kim
Source:: Journal of Ginseng Research 2022 v.46 no.3 pp. 396-407
ISSN:: 1226-8453
Subject:: Panax; Western blotting; antineoplastic activity; apoptosis; cell cycle checkpoints; cell growth; cell proliferation; colorectal neoplasms; morbidity; mortality; neoplasm cells; research; toxicity; transfection; xenotransplantation
Abstract:: ... Colorectal cancer (CRC) has a high morbidity and mortality worldwide. 20 (S)-ginsenoside Rh2 (G-Rh2) is a natural compound extracted from ginseng, which exhibits anticancer effects in many cancer types. In this study, we demonstrated the effect and underlying molecular mechanism of G-Rh2 in CRC cells in vitro and in vivo. Cell proliferation, migration, invasion, apoptosis, cell cycle, and western ...
DOI:: 10.1016/j.jgr.2021.07.004
: https://doi.org/10.1016/j.jgr.2021.07.004

26. 3,4,5‐O‐tricaffeoylquinic acid alleviates ionizing radiation‐induced injury in vitro and in vivo through regulating ROS/JNK/p38 signaling

Author:: Jiajun Liu; Wen Hu; Xiaoying Ma; Xin Liang; Long Lin; Jianming Huang; Jianwen Liu
Source:: Environmental toxicology 2022 v.37 no.2 pp. 349-361
ISSN:: 1520-4081
Subject:: Azolla; Western blotting; agonists; apoptosis; caspases; cell lines; cytotoxicity; digestive system; ecotoxicology; epithelial cells; immune system; membrane potential; mitochondria; radioprotective effect; radiotherapy
Abstract:: ... Ionizing radiation (IR) brings many health problems to humans, causing damage to the digestive system, hematopoietic system, and immune system. Natural compounds derived from plants have attracted widespread attention due to their low toxicity. Here, we found that 3,4,5‐O‐tricaffeoylquinic acid (tCQA) extracted from natural plant Azolla imbricata could significantly alleviate the systemic damage i ...
DOI:: 10.1002/tox.23403
: https://doi.org/10.1002/tox.23403

27. 3,4-Dihydroxyphenylacetic acid ameliorates gut barrier dysfunction via regulation of MAPK-MLCK pathway in type 2 diabetes mice

Author:: Min Liu; Li Wang; Bijun Huang; Qun Lu; Rui Liu
Source:: Life sciences 2022 v.305 pp. 120742
ISSN:: 0024-3205
Subject:: Western blotting; absorption barrier; anti-inflammatory activity; blood glucose; body weight; digestive system diseases; glutathione; high fat diet; hyperglycemia; inflammation; insulin; insulin resistance; interleukin-10; intestines; lipopolysaccharides; malondialdehyde; mitogen-activated protein kinase; myosin; noninsulin-dependent diabetes mellitus; oxidative stress; protein synthesis; streptozotocin; superoxide dismutase; tight junctions
Abstract:: ... This study aims to investigate whether 3,4-dihydroxyphenylacetic acid (DHAA) can improve gut barrier function by inhibiting the mitogen-activated protein kinase (MAPK) - myosin light-chain kinase (MLCK) signaling pathway in type 2 diabetes (T2D) mice. T2D mice were induced by a high-fat diet combined with streptozotocin. T2D mice were intragastrically administered with DHAA at 75 and 150 mg kg/bod ...
DOI:: 10.1016/j.lfs.2022.120742
: https://doi.org/10.1016/j.lfs.2022.120742

28. IL- 37 alleviates liver granuloma caused by Schistosoma japonicum infection by inducing alternative macrophage activation

Author:: Cuiping Ren; Fengchun Liu; Chen Xing; Ruyu Zhao; Xiaoxue Tang; Miao Liu; Wenda Gao; Jijia Shen
Source:: Parasites & vectors 2022 v.15 no.1 pp. 300
ISSN:: 1756-3305
Subject:: AMP-activated protein kinase; Schistosoma japonicum; Western blotting; blood serum; coculture; enzyme-linked immunosorbent assay; fibrosis; granuloma; interleukins; liver; liver cirrhosis; liver function; macrophage activation; macrophages; mice; people; phenotype; phosphorylation; reverse transcriptase polymerase chain reaction; schistosomiasis
Abstract:: ... BACKGROUND: Hepatic macrophages regulate liver granuloma formation and fibrosis caused by infection with Schistosoma japonicum, with the manner of regulation dependent on macrophage activation state. Interleukin (IL)-37 may have immunomodulatory effects on macrophages. However, whether IL-37 can affect liver granuloma formation and fibrosis by affecting the polarization of macrophages in S. japoni ...
DOI:: 10.1186/s13071-022-05420-6
: https://doi.org/10.1186/s13071-022-05420-6

29. 5-Methoxytryptophan pretreatment alleviates lipopolysaccharide-induced cardiac injury and dysfunction

Author:: Yang Fu; Yi-Fei Dong
Source:: Applied biological chemistry 2022 v.65 no.1 pp. 36
ISSN:: 2468-0834
Subject:: Western blotting; apoptosis; biomarkers; cardiomyopathy; cardioprotective effect; echocardiography; fibroblasts; heart; inflammation; interleukin-10; interleukin-6; lipopolysaccharides; metabolites; protein content; therapeutics; tryptophan
Abstract:: ... Reducing inflammation is a promising therapeutic approach for sepsis-induced cardiomyopathy (SIC). The 5-Methoxytryptophan (5-MTP) is a tryptophan metabolite that demonstrates anti-inflammatory, anti-fibrosis, anti-tumorigenesis, and anti-senescence features. Current investigations aimed to assess the 5-MTP pretreatment impacts on lipopolysaccharide (LPS)-induced cardiac injury and dysfunction. Fo ...
DOI:: 10.1186/s13765-022-00705-x
: https://doi.org/10.1186/s13765-022-00705-x

30. 5‐Heptadecylresorcinol Protects against Atherosclerosis in Apolipoprotein E‐Deficient Mice by Modulating SIRT3 Signaling: The Possible Beneficial Effects of Whole Grain Consumption

Author:: Yiming Hao; Zihui Yang; Qing Li; Ziyuan Wang; Jie Liu; Jing Wang
Source:: Molecular nutrition & food research 2022 v.66 no.9 pp. e2101114
ISSN:: 1613-4125
Subject:: Western blotting; apoptosis; atherosclerosis; biomarkers; blood serum; cholesterol; fluorescent antibody technique; food research; grain consumption; health claims; heart; high fat diet; histology; ingredients; mitochondria; risk; triacylglycerols; whole grain foods
Abstract:: ... SCOPE: Whole grain consumption has been proven to be inversely associated with the risk of cardiovascular diseases. As a biomarker for whole grain dietary intake, 5‐heptadecylresorcinol (AR‐C17) has attracted increased attention due to its potential health‐improving activity. However, the beneficial effect of AR‐C17 on atherosclerosis prevention and the underlying mechanism remain unclear. METHODS ...
DOI:: 10.1002/mnfr.202101114
: https://doi.org/10.1002/mnfr.202101114

31. 6-OH-BDE-47 inhibited proliferation of skin fibroblasts from pygmy killer whale by inducing cell cycle arrest

Author:: Tong Li; Yajing Sun; Ying Zeng; Edmond Sanganyado; Bo Liang; Wenhua Liu
Source:: Science of the total environment 2022 v.807 pp. 150561
ISSN:: 0048-9697
Subject:: Orcinus orca; Western blotting; aquatic food webs; bioaccumulation; biphenyl; cell cycle checkpoints; cell proliferation; cyclin-dependent kinase; cyclins; environment; fibroblasts; hydroxylation; interphase; toxicity; toxicology
Abstract:: ... Hydroxylated polybrominated diphenyl ethers (OH-BDEs) are major transformation products of PBDEs that readily bioaccumulate in the marine food web. Although 6-OH-BDE-47 is frequently and abundantly detected in cetaceans, its potential toxic effects are largely unknown. We explored the toxicological pathways and mechanisms of OH-BDEs by exposing pygmy killer whale skin fibroblast cell lines (PKW-LW ...
DOI:: 10.1016/j.scitotenv.2021.150561
: https://doi.org/10.1016/j.scitotenv.2021.150561

32. 6-methoxydihydroavicine, the alkaloid extracted from Macleaya cordata (Willd.) R. Br. (Papaveraceae), triggers RIPK1/Caspase-dependent cell death in pancreatic cancer cells through the disruption of oxaloacetic acid metabolism and accumulation of reactive oxygen species

Author:: Nengfang Ma; Fugen Shangguan; Hongfei Zhou; Huimin Huang; Jun Lei; Jing An; Guihua Jin; Weiwei Zhuang; Shipeng Zhou; Shijia Wu; Hongping Xia; Hailong Yang; Linhua Lan
Source:: Phytomedicine 2022 v.102 pp. 154164
ISSN:: 0944-7113
Subject:: Macleaya cordata; Western blotting; alkaloids; apoptosis; caspases; cell growth; energy metabolism; flow cytometry; glycolysis; homeostasis; mitochondria; mitophagy; neoplasm cells; oxaloacetic acid; pancreatic neoplasms; reactive oxygen species
Abstract:: ... Many extracts and purified alkaloids of M. cordata (Papaveraceae family) have been reported to display promising anti-tumor effects by inhibiting cancer cell growth and inducing apoptosis in many cancer types. However, no evidence currently exists for anti-pancreatic cancer activity of alkaloids extracted from M. cordata, including a novel alkaloid named 6‑methoxy dihydrosphingosine (6-Methoxydihy ...
DOI:: 10.1016/j.phymed.2022.154164
: https://doi.org/10.1016/j.phymed.2022.154164

33. 7,8-Dihydroxyflavone attenuates the virulence of Staphylococcus aureus by inhibiting alpha-hemolysin

Author:: Nan Bian; Xiangqian Chen; Xinran Ren; Zishu Yu; Mengli Jin; Xiaoyu Chen; Chang Liu; Yanhe Luan; Lin Wei; Ying Chen; Wu Song; Yicheng Zhao; Bingmei Wang; Tao Jiang; Chi Zhang; Zunhua Shu; Xin Su; Li Wang
Source:: World journal of microbiology & biotechnology 2022 v.38 no.11 pp. 200
ISSN:: 0959-3993
Subject:: Staphylococcus aureus; Western blotting; animals; biotechnology; cytotoxicity; genes; hemolysis; hospitals; microbiology; synergism; therapeutics; transcription factors; vancomycin; viability; virulence
Abstract:: ... Staphylococcus aureus (S. aureus), a Gram-positive bacteria, is an incurable cause of hospital and community-acquired infections. Inhibition bacterial virulence is a viable strategy against S. aureus infections based on the multiple virulence factors secreted by S. aureus. Alpha-hemolysin (Hla) plays a crucial role in bacteria virulence without affecting bacterial viability. Here, we identified th ...
DOI:: 10.1007/s11274-022-03378-2
: https://doi.org/10.1007/s11274-022-03378-2

34. ABCA8 inhibits breast cancer cell proliferation by regulating the AMP activated protein kinase/mammalian target of rapamycin signaling pathway

Author:: Chunliu Lv; Han Yang; Jinsong Yu; Xiaowei Dai
Source:: Environmental toxicology 2022 v.37 no.6 pp. 1423-1431
ISSN:: 1520-4081
Subject:: Western blotting; breast neoplasms; carcinogenesis; cell growth; cell proliferation; data collection; ecotoxicology; gene expression regulation; mammals; neoplasm cells; prognosis; protein kinases; rapamycin
Abstract:: ... ATP‐binding cassette (ABC) subfamily A member 8 (ABCA8) has been reported to play a vital role in cancer development. Our study aimed to explore the role and the molecular mechanism of ABCA8 in breast cancer (BC) progression. GSE65194, GSE15852, and GSE45827 datasets were used to identify differentially expressed genes (DEGs) in BC. The diagnosis and prognosis value were determined using ROC curve ...
DOI:: 10.1002/tox.23495
: https://doi.org/10.1002/tox.23495

35. ACSL4 promotes colorectal cancer and is a potential therapeutic target of emodin

Author:: Guoliang Dai; Dong Wang; Shitang Ma; Shengwei Hong; Kang Ding; Xiying Tan; Wenzheng Ju
Source:: Phytomedicine 2022 v.102 pp. 154149
ISSN:: 0944-7113
Subject:: Rheum palmatum; Western blotting; antineoplastic activity; carcinogenesis; cell proliferation; colorectal neoplasms; data collection; databases; emodin; gene expression regulation; immunohistochemistry; ingredients; mice; mortality; secretion; therapeutics; vascular endothelial growth factor receptor-1; vascular endothelial growth factor receptor-2
Abstract:: ... Colorectal cancer (CRC) is an important death-related disease in the world and new therapeutic strategies are urgently needed to reduce mortality. Several studies have demonstrated that emodin, the main ingredient of Rheum palmatum, fights cancer but its potential anti-tumor effect on CRC is still unknown. The present study is aimed to explore the potential anti-tumor effects of emodin against CRC ...
DOI:: 10.1016/j.phymed.2022.154149
: https://doi.org/10.1016/j.phymed.2022.154149

36. ADAMTS8 inhibited lung cancer progression through suppressing VEGFA

Author:: Yutian Zhang; Kang Hu; Ziyi Qu; Zhihong Xie; Fei Tian
Source:: Biochemical and biophysical research communications 2022 v.598 pp. 1-8
ISSN:: 0006-291X
Subject:: Western blotting; apoptosis; cell proliferation; epithelial cells; flow cytometry; gene expression regulation; immunohistochemistry; lung neoplasms; lungs; neoplasm cells; neoplasm progression; plasmids; research; survival rate; transfection; xenotransplantation
Abstract:: ... ADAMTS8 expression has been identified to be low in many cancers including lung cancer. However, the specific functions and regulatory system of ADAMTS8 remain to be unveiled. To study the potential modulatory mechanism of ADAMTS8 in lung cancer in cell and xenograft mice models. Differential expression of ADAMTS8 in lung cancer was analyzed on online tools. So was the overall survival curve in as ...
DOI:: 10.1016/j.bbrc.2022.01.110
: https://doi.org/10.1016/j.bbrc.2022.01.110

37. AICAR stimulates mitochondrial biogenesis and BCAA catabolic enzyme expression in C2C12 myotubes

Author:: Jason S. Hinkle; Caroline N. Rivera; Roger A. Vaughan
Source:: Biochimie 2022 v.195 pp. 77-85
ISSN:: 0300-9084
Subject:: Western blotting; acidification; amino acids; biogenesis; blood; catabolism; gene expression; genes; glycolysis; insulin resistance; keto acids; metabolites; mitochondria; models; myotubes; noninsulin-dependent diabetes mellitus; oxidoreductases; oxygen consumption; peroxisome proliferator-activated receptor gamma; protein kinases; protein synthesis; skeletal muscle
Abstract:: ... Type 2 diabetes is characterized by reduced insulin sensitivity, elevated blood metabolites, and reduced mitochondrial metabolism. Insulin resistant populations often exhibit reduced expression of genes governing mitochondrial metabolism such as peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PGC-1α). Interestingly, PGC-1α regulates the expression of branched-chain amino acid ...
DOI:: 10.1016/j.biochi.2021.11.004
: https://doi.org/10.1016/j.biochi.2021.11.004

38. ALDH6A1 weakens the progression of colon cancer via modulating the RAS/RAF/MEK/ERK pathway in cancer cell lines

Author:: Xiang Li; Nan Wang; Yutong Wu; Yidan Liu; Ruoyu Wang
Source:: Gene 2022 v.842 pp. 146757
ISSN:: 0378-1119
Subject:: Western blotting; adenocarcinoma; aldehyde dehydrogenase; apoptosis; colon; colorectal neoplasms; fibrosarcoma; genes; metalloproteinases; neoplasm cells; pathogenesis; quantitative polymerase chain reaction; rats; transfection; viruses
Abstract:: ... Aldehyde dehydrogenase 6 family member A1 (ALDH6A1) is associated with multiple diseases, but its pathogenesis in colon cancer (CC) is ambiguous and needs further study so that this research explores the function of ALDH6A1 in CC. The level of ALDH6A1 in colon adenocarcinoma (COAD), CC tissues, and cells was measured by starBase v2.0, quantitative real-time polymerase chain reaction (qRT-PCR), and ...
DOI:: 10.1016/j.gene.2022.146757
: https://doi.org/10.1016/j.gene.2022.146757

39. ASPN Is a Potential Biomarker and Associated with Immune Infiltration in Endometriosis

Author:: Li Wang; Jing Sun
Source:: Genes 2022 v.13 no.8 pp. -
ISSN:: 2073-4425
Subject:: B-lymphocytes; T-lymphocytes; Western blotting; biomarkers; calcium; chemokines; cytotoxicity; data collection; databases; endometriosis; endometrium; endothelial cells; extracellular matrix; female genital diseases; fibroblasts; gene expression; gene expression regulation; genes; immunotherapy; metastasis; muscle contraction; patients; regression analysis; smooth muscle
Abstract:: ... Objective: Endometriosis is a benign gynecological disease characterized by distant metastasis. Previous studies have discovered abnormal numbers and function of immune cells in endometriotic lesions. We aimed to find potential biomarkers of endometriosis and to explore the relationship between ASPN and the immune microenvironment of endometriosis. Methods: We obtained the GSE141549 and GSE7305 da ...
DOI:: 10.3390/genes13081352
: https://doi.org/10.3390/genes13081352

40. ASPP2 reduction attenuates HBV induced chronic liver damage: A hybrid mouse model study

Author:: Yang Wang; Yang Che; ShanShan Wang; JinMing Wang; Xiaoni Liu; Buxin Kou; Yuanyue Guan; Dexi Chen; Ying Shi
Source:: Biochemical and biophysical research communications 2022 v.610 pp. 61-69
ISSN:: 0006-291X
Subject:: Hepatitis B virus; Western blotting; apoptosis; autophagy; blood serum; eosin; humans; hybrids; immune system; immunohistochemistry; inflammation; innate immunity; liver; metabolism; mice; necrosis; progeny; research; transcriptome; transcriptomics
Abstract:: ... P53 Apoptosis Stimulating Protein 2 (ASPP2) is confirmed to participate in cellular activities including apoptosis, proliferation, autophagy, injury and so on. However, the role of ASPP2 in Hepatitis B virus (HBV) infection has not been reported in detail. The study explored the role of ASPP2 in HBV induced chronic liver damage. Transcriptome profiling of ASPP2-konckdown mouse liver were analyzed ...
DOI:: 10.1016/j.bbrc.2022.03.109
: https://doi.org/10.1016/j.bbrc.2022.03.109

41. ATP6V1H deficiency impairs glucose tolerance by augmenting endoplasmic reticulum stress in high fat diet fed mice

Author:: Shaoqing Yang; Yuzhuan Hou; Hengwei Zhang; Ying Hao; Yanli Zhang; Zanyan Zhao; Wenyan Ruan; Xiaohong Duan
Source:: Archives of biochemistry and biophysics 2022 v.716 pp. 109116
ISSN:: 0003-9861
Subject:: H-transporting ATP synthase; Western blotting; biophysics; diabetes; endoplasmic reticulum stress; glucose; glucose tolerance; high fat diet; insulin; insulin secretion; models; proton pump; transcriptome; transportation; vacuoles
Abstract:: ... Vacuolar H⁺-ATPase (V-ATPase) is a ubiquitous proton pump that mediates the proton transmembrane transportation in various cells. Previously, H subunit of V-ATPase (ATP6V1H) was found to be related with insulin secretion and diabetes. However, the mechanism by which ATP6V1H regulates insulin secretion and glucose metabolism remains unclear. Herein, we established a high-fat-diet (HFD) fed model wi ...
DOI:: 10.1016/j.abb.2022.109116
: https://doi.org/10.1016/j.abb.2022.109116

42. ATX/LPA axis regulates FAK activation, cell proliferation, apoptosis, and motility in human pancreatic cancer cells

Author:: Yan Liao; Lei Liu; Jiayao Yang; Zhaohong Shi
Source:: In vitro cellular & developmental biology 2022 v.58 no.4 pp. 307-315
ISSN:: 1071-2690
Subject:: Western blotting; adhesion; apoptosis; autocrine signaling; carcinogenesis; cell membranes; cell proliferation; cell viability; cultured cells; flow cytometry; fluorescent antibody technique; humans; lysophospholipids; non-specific protein-tyrosine kinase; pancreatic neoplasms; protein synthesis; secretion
Abstract:: ... Previous studies implicated ATX/LPA axis as a potential driver of tumorigenesis and progression in pancreatic cancer. This study aimed to determine the existence of the autocrine pathway of ATX/LPA action in pancreatic cancer cells, and to elucidate its influence on focal adhesion kinase (FAK) activation, cellular proliferation, apoptosis, and migration. Firstly, we identified the lysophosphatidic ...
DOI:: 10.1007/s11626-022-00660-3
: https://doi.org/10.1007/s11626-022-00660-3

43. Abnormal Expression of microRNA-296-3p in Type 2 Diabetes Patients and its Role in Pancreatic β-Cells Function by Targeting Tensin Homolog Deleted on Chromosome Ten

Author:: Minggang Cheng; Yichen Guo; Weichuan Zhong; Xueyan Chen; Guangzhou Guo
Source:: Biochemical genetics 2022 v.60 no.1 pp. 39-53
ISSN:: 0006-2928
Subject:: Western blotting; apoptosis; blood glucose; blood serum; cell proliferation; cell viability; chromosomes; flow cytometry; insulin; insulin secretion; noninsulin-dependent diabetes mellitus; protective effect; reverse transcriptase polymerase chain reaction; therapeutics; transfection; uric acid
Abstract:: ... Diabetes mellitus (DM), a familiar disease, is characterized by high blood glucose levels owing to insulin deficiency. Researches have suggested that the incidence rate of diabetes is increasing and it has become an important global epidemic. The type 2 diabetes mellitus (T2DM) is featured with pancreatic β-cell loss and lack of insulin release. Nevertheless, the therapeutic methods that was helpf ...
DOI:: 10.1007/s10528-021-10083-6
: https://doi.org/10.1007/s10528-021-10083-6

44. Activation of PGC‐1α via isoliquiritigenin‐induced downregulation of miR‐138‐5p alleviates nonalcoholic fatty liver disease

Author:: Lu Wang; Xiaohui Wang; Lina Kong; Yingying Li; Kai Huang; Jingjing Wu; Changyuan Wang; Huijun Sun; Pengyuan Sun; Jiangning Gu; Haifeng Luo; Kexin Liu; Qiang Meng
Source:: Phytotherapy research 2022 v.36 no.2 pp. 899-913
ISSN:: 0951-418X
Subject:: Western blotting; bioinformatics; drugs; fatty liver; fluorescent antibody technique; histopathology; inflammation; interleukin-6; lipid metabolism; lipids; liver; luciferase; metabolic diseases; phytotherapy; quantitative polymerase chain reaction; reactive oxygen species; research
Abstract:: ... Nonalcoholic fatty liver disease (NAFLD), a metabolic disease, has received wide attention worldwide. However, there is no approved effective drug for NAFLD treatment. In the study, H&E and Oil Red O staining were employed to detect liver histopathological changes and the accumulation of lipid droplets. Quantitative real‐time PCR, Western blot, bioinformatics, luciferase assay, immunofluorescence ...
DOI:: 10.1002/ptr.7334
: https://doi.org/10.1002/ptr.7334

45. Activation of mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K/Akt/mTOR signaling pathway by voacamine suppress breast cancer progression

Author:: Yi Zuo; Chao-zheng Zhang; Qing Ren; Yao Chen; Xiao Li; Ji-rui Yang; Hong-xiang Li; Wen-tao Tang; Hing-Man HO; Chen Sun; Mei-mei Li; Bo Ren; Yun Deng; Mao-lin Wang; Jun Lu
Source:: Phytomedicine 2022 v.99 pp. 154015
ISSN:: 0944-7113
Subject:: Voacanga africana; Western blotting; alkaloids; apoptosis; breast neoplasms; cell proliferation; cyclin-dependent kinase; cyclins; flow cytometry; humans; interphase; membrane potential; mice; mitochondrial membrane; morbidity; mortality; neoplasm cells; neoplasm progression; protein synthesis; reactive oxygen species; toxicity
Abstract:: ... Breast cancer is one of the malignant tumors with the highest morbidity and mortality rate. Numerous efficient anti-breast cancer drugs are being derived from the development of natural products. Voacamine (VOA), a bisindole alkaloid isolated from Voacanga africana Stapf, possesses various pharmacological and biological activities. In this study, we investigated the efficacy of VOA against breast ...
DOI:: 10.1016/j.phymed.2022.154015
: https://doi.org/10.1016/j.phymed.2022.154015

46. Active legumain promotes invasion and migration of neuroblastoma by regulating epithelial-mesenchymal transition

Author:: Min Zhang; Jianhua Zhu; Wei Wang; Zhiteng Jiang
Source:: Open life sciences 2022 v.17 no.1 pp. 676-685
ISSN:: 2391-5412
Subject:: Western blotting; asparagine; cadherins; gene amplification; gene targeting; genes; humans; legumain; metastasis; neoplasms; slugs; transfection; vimentin
Abstract:: ... Neuroblastoma (NB) is a commonly occurring malignancy in children. Epithelial-mesenchymal transition (EMT) is an adaptive change in promoting tumor metastasis. As an important factor in regulating tumor metastasis, whether legumain could promote metastasis of NB by EMT is still unexplored. Legumain is the active form of prolegumain, abundant in tumor plasma. So in the current study, different form ...
DOI:: 10.1515/biol-2022-0012
: https://doi.org/10.1515/biol-2022-0012

47. Acute lead acetate induces neurotoxicity through decreased synaptic plasticity-related protein expression and disordered dendritic formation in nerve cells

Author:: Lingli Chen; Yuye Liu; Penghuan Jia; Hongli Zhang; Zhihong Yin; Dongfang Hu; Hongmei Ning; Yaming Ge
Source:: Environmental science and pollution research 2022 v.29 no.39 pp. 58927-58935
ISSN:: 0944-1344
Subject:: Western blotting; axons; cell membranes; cerebral cortex; dose response; females; heavy metals; hippocampus; lead acetate; memory; mice; microscopy; nerve tissue; neurotoxicity; permeability; pollution; protein synthesis; research; survival rate
Abstract:: ... Lead (Pb) is a widespread environmental heavy metal that can damage the cerebral cortex and hippocampus, and reduce the learning and memory ability in humans and animals. In vivo and in vitro models of acute lead acetate exposure were established to further study the mechanism of neurons injury. In this study, 4-week-old female Kunming mice were randomly divided into four groups. Each group was tr ...
DOI:: 10.1007/s11356-022-20051-1
: https://doi.org/10.1007/s11356-022-20051-1

48. Adiponectin affects uterine steroidogenesis during early pregnancy and the oestrous cycle: An in vitro study

Author:: M. Kiezun; K. Dobrzyn; E. Zaobidna; E. Rytelewska; K. Kisielewska; M. Gudelska; K. Orzechowska; G. Kopij; K. Szymanska; B. Kaminska; T. Kaminski; N. Smolinska
Source:: Animal reproduction science 2022 v.245 pp. 107067
ISSN:: 0378-4320
Subject:: Western blotting; adiponectin; endometrium; energy balance; estradiol; estrone; estrous cycle; gene expression; genes; insulin; myometrium; pregnancy; protein synthesis; radioimmunoassays; secretion; steroidogenesis; swine; testosterone
Abstract:: ... Reproduction in females is an energetically demanding process. We assumed that adiponectin (ADPN), known for its role in energy balance maintenance, is also engaged in the regulation of uterine steroidogenesis in the pig. We determined the impact of ADPN alone or in combination with insulin (INS) on testosterone (T), estrone (E₁) and estradiol (E₂) secretion by porcine endometrium and myometrium, ...
DOI:: 10.1016/j.anireprosci.2022.107067
: https://doi.org/10.1016/j.anireprosci.2022.107067

49. Aerobic exercise improves adipogenesis in diet-induced obese mice via the lncSRA/p38/JNK/PPARγ pathway

Author:: Baoai Wu; Jiyuan Ding; Anping Chen; Yicun Song; Cong Xu; Fujun Tian; Jinfeng Zhao
Source:: Nutrition research 2022 v.105 pp. 20-32
ISSN:: 0271-5317
Subject:: Western blotting; adipogenesis; adiposity; blood lipids; epididymis; exercise; lipid metabolism; lipids; mitogen-activated protein kinase; nutrition research; obesity; risk factors; spectrophotometers; viruses; white adipose tissue
Abstract:: ... Adipogenesis is one of the triggers of obesity, which is a risk factor for various metabolic diseases. Long noncoding RNA steroid receptor RNA activator (lncRNA-SRA) is closely related to adipogenesis and p38/JNK mitogen-activated protein kinase mediates lipid production by regulating peroxisome proliferator-activated receptor gamma (PPARγ). Aerobic exercise can be efficient in improving adiposity ...
DOI:: 10.1016/j.nutres.2022.04.004
: https://doi.org/10.1016/j.nutres.2022.04.004

50. Aerobic exercise improves intestinal mucosal barrier dysfunction through TLR4/MyD88/NF-κB signaling pathway in diabetic rats

Author:: Yuzhen Wu; Xia Liu; Jianping Li; Wei Ji; Qinghua Tian; Shichen Li
Source:: Biochemical and biophysical research communications 2022 pp. -
ISSN:: 0006-291X
Subject:: Toll-like receptor 4; Western blotting; blood glucose; blood serum; diabetes; diamine oxidase; exercise; insulin; insulin resistance; interleukin-6; intestinal mucosa; lipopolysaccharides; models; necrosis; neoplasms; occludins; research; transmission electron microscopy; villi
Abstract:: ... This study examined the effects of aerobic exercise on the intestinal mucosal barrier dysfunction in diabetic rats. We established a diabetic rats model consisting of three groups: normal control (NC), diabetes control (DC), and diabetes eight-week aerobic exercise (DE). We measured serum fasting blood glucose (FBG), insulin (INS), diamine oxidase (DAO), D(-)-lactate (D-Lac), lipopolysaccharide (L ...
DOI:: 10.1016/j.bbrc.2022.09.075
: https://doi.org/10.1016/j.bbrc.2022.09.075

51. Aeromonas hydrophila Ssp1: A secretory serine protease that disrupts tight junction integrity and is essential for host infection

Author:: Chen Feng; Xiaofeng Liu; Niewen Hu; Yiyang Tang; Mengzhe Feng; Zejun Zhou
Source:: Fish & shellfish immunology 2022 v.127 pp. 530-541
ISSN:: 1050-4648
Subject:: Aeromonas hydrophila; Gram-negative bacteria; Vibrio; Western blotting; biofilm; dysbiosis; fish; genes; host range; intestinal microorganisms; intestines; mutants; myosin light chain kinase; myosin light chains; occludins; pathogens; permeability; serine proteinases; shellfish; tight junctions; transcriptomics; virulence
Abstract:: ... Aeromonas hydrophila is a Gram-negative bacterial pathogen with a broad host range, including fish and humans. In this study, we examined the function of a secretory serine protease (named Ssp1) identified in pathogenic A. hydrophila CCL1. Ssp1 possesses a trypsin-like serine protease domain and contains two conserved PDZ domains. Recombinant Ssp1 protein (rSsp1) treatment increased intestinal per ...
DOI:: 10.1016/j.fsi.2022.06.068
: https://doi.org/10.1016/j.fsi.2022.06.068

52. Aesculetin exhibited anti-inflammatory activities through inhibiting NF-кB and MAPKs pathway in vitro and in vivo

Author:: Shou-Kai Wang; Ting-Xiao Chen; Wei Wang; Ling-Ling Xu; Yu-Qing Zhang; Zhen Jin; You-Bin Liu; You-Zhi Tang
Source:: Journal of ethnopharmacology 2022 v.296 pp. 115489
ISSN:: 0378-8741
Subject:: Western blotting; anti-inflammatory activity; anti-inflammatory agents; colitis; colon; interleukin-6; macrophages; mice; secretion; traditional medicine; weight loss
Abstract:: ... Aesculetin (6,7-dihydroxy-2H-1-benzopyran-2-one) has been reported to exhibit potent anti-inflammatory property both in vitro and in vivo. In this study, we evaluated the anti-inflammatory effect and investigated underlying molecular mechanisms of aesculetin in LPS-induced RAW264.7 macrophages and DSS-induced colitis. In this study, the production of NO, TNF-α, and IL-6 were measured to identify t ...
DOI:: 10.1016/j.jep.2022.115489
: https://doi.org/10.1016/j.jep.2022.115489

53. Agrimoniin sensitizes pancreatic cancer to apoptosis through ROS-mediated energy metabolism dysfunction

Author:: Xiandong Zhu; Yan Zhang; Yongqiang Wang; Hewei Zhang; Xiaowu Wang; Hengjie Tang; Hongjian Huang; Zijun Zhou; Bicheng Chen; Linxiao Sun
Source:: Phytomedicine 2022 v.96 pp. 153807
ISSN:: 0944-7113
Subject:: Agrimonia pilosa; Western blotting; acidification; apoptosis; cancer therapy; cell growth; cell proliferation; drug development; drug therapy; energy metabolism; flow cytometry; membrane potential; mitochondria; mitochondrial membrane; oxygen consumption; pancreatic neoplasms; polyphenols; protein synthesis; radiotherapy; reactive oxygen species; toxicity
Abstract:: ... Pancreatic cancer is a fatal tumor, which is one of the most common malignant tumors at present. Patients with pancreatic cancer also respond poorly to chemotherapy or radiation therapy and may be accompanied by serious adverse reactions. Therefore, to find an effective way to inhibit the initiation and progression of pancreatic cancer is important to improve the survival and development of patien ...
DOI:: 10.1016/j.phymed.2021.153807
: https://doi.org/10.1016/j.phymed.2021.153807

54. Agrobacterium tumefaciens–mediated genetic transformation and overexpression of the flavonoid 3′5′-hydroxylase gene increases the flavonoid content of the transgenic Aconitum carmichaelii Debx. plant

Author:: Thi Ngoc Lan Nguyen; Thi Thu Hoan Hoang; Huu Quan Nguyen; Quang Tan Tu; Thi Hong Tran; Thi Mai Thu Lo; Thi Thu Thuy Vu; Hoang Mau Chu
Source:: In vitro cellular & developmental biology 2022 v.58 no.1 pp. 93-102
ISSN:: 1054-5476
Subject:: Aconitum carmichaelii; Agrobacterium radiobacter; Western blotting; antioxidants; biosynthesis; enzymes; flavonoids; genetic transformation; greenhouses; medicinal plants; polyacrylamide gel electrophoresis; polymerase chain reaction; polysaccharides; protein content; transgenes
Abstract:: ... Aconitum carmichaelii Debx. is a medicinal plant that contains a variety of valuable medicinal substances, including flavonoids, alkaloids, and polysaccharides. Flavonoids are important substances because of their antioxidant, antiproliferative, and anticancer effects, but the flavonoid content in A. carmichaelii is low. Flavonoid 3′5′-hydroxylase (F3′5′H) is a key enzyme that catalyzes the final ...
DOI:: 10.1007/s11627-021-10190-4
: https://doi.org/10.1007/s11627-021-10190-4

55. Airway epithelial dysfunction and mesenchymal transition in chronic obstructive pulmonary disease: Role of Oct-4

Author:: Rosalia Gagliardo; Fabio Bucchieri; Angela Marina Montalbano; Giusy Daniela Albano; Delphine Gras; Alberto Fucarino; Roberto Marchese; Giulia Anzalone; Chiara Lo Nigro; Pascal Chanez; Mirella Profita
Source:: Life sciences 2022 v.288 pp. 120177
ISSN:: 0024-3205
Subject:: Western blotting; adhesion; biopsy; cell proliferation; cigarettes; electrical resistance; epithelial cells; epithelium; homeostasis; immune response; immunohistochemistry; interleukin-8; liquid-air interface; pathophysiology; respiratory tract diseases; smoke; transcription factors
Abstract:: ... The airway epithelium is a dynamic tissue that undergoes slow but constant renewal. Dysregulation of airway epithelial function related to cigarette smoke exposure plays an important role in the pathophysiology of COPD. Oct4 is a transcription factor responsible for maintaining cellular self-renewal and regeneration, and CD146 and CD105/Endoglin are adhesion molecules involved in cell proliferatio ...
DOI:: 10.1016/j.lfs.2021.120177
: https://doi.org/10.1016/j.lfs.2021.120177

56. Albumin (ALB) and protein disulfide isomerase family A member 4 (PDIA4) are novel markers to predict sperm freezability of Erhualian boar

Author:: Shifeng Tong; Chang Yin; Yuzhu Ge; Zhibin Ren; Jingli Tao; Yang Liu
Source:: Cryobiology 2022 pp. -
ISSN:: 0011-2240
Subject:: Western blotting; albumins; boars; cold tolerance; cryobiology; fluorescent antibody technique; freeze-thaw cycles; protein disulfide-isomerase; proteomics; semen quality; sperm quality
Abstract:: ... The frozen semen of Erhualian pig can promote the continuous improvement of commercial pigs, but currently, frozen semen fails to satisfy the practical application requirement. Oxidative damage is one of the crucial factors affecting the quality of frozen semen; besides, there are individual differences in boar sperm freezability. Based on the previous analysis of the proteomic differences of Erhu ...
DOI:: 10.1016/j.cryobiol.2022.09.006
: https://doi.org/10.1016/j.cryobiol.2022.09.006

57. All-trans retinoic acid-mediated miR-30a up-regulation suppresses autophagy and sensitizes gastric cancer cells to cisplatin

Author:: Asadollah Abbasi; Mohammadali Hosseinpourfeizi; Reza Safaralizadeh
Source:: Life sciences 2022 v.307 pp. 120884
ISSN:: 0024-3205
Subject:: Western blotting; apoptosis; autophagy; cell cycle checkpoints; cisplatin; culture media; drug therapy; flow cytometry; genes; microRNA; retinoic acid; stem cells; stomach neoplasms; toxicity testing
Abstract:: ... The potential of all-trans retinoic acid (ATRA) in regulating some microRNAs (miRNAs) involved in multiple cancer-related pathways, including resistance to chemotherapeutics, may be a valuable idea for overcoming the CDDP resistance of GC cells. Treatment of gastric AGS and MKN-45 cells with CDDP enriched the CDDP surviving cells (CDDP-SCs). The abilities of chemoresistance to CDDP drug, migration ...
DOI:: 10.1016/j.lfs.2022.120884
: https://doi.org/10.1016/j.lfs.2022.120884

58. Alleviating Effects of Black Soybean Peptide on Oxidative Stress Injury Induced by Lead in PC12 Cells via Keap1/Nrf2/TXNIP Signaling Pathway

Author:: Ning Li; Liuding Wen; Tiange Li; Huijie Yang; Mingwu Qiao; Tianlin Wang; Lianjun Song; Xianqing Huang; Mingming Li; Erkigul Bukyei; Fangyu Wang
Source:: Nutrients 2022 v.14 no.15 pp. -
ISSN:: 2072-6643
Subject:: Western blotting; cell viability; lead; oxidative stress; peptides; protein synthesis; soybeans
Abstract:: ... Many researchers have found that Pb exposure can cause oxidative stress damage to the body’s tissue. Black soybean peptide (BSP) has a variety of physiological functions, especially in terms of oxidative stress. Nevertheless, the mitigation function of BSPs on Pb-induced oxidative stress damage in PC12 cells has not been clearly defined. In this study, cell viability was detected by CCK8. Oxidativ ...
DOI:: 10.3390/nu14153102
: https://doi.org/10.3390/nu14153102

59. Allicin attenuated hepatic ischemia/reperfusion injury in mice by regulating PPARγ-IRAK-M-TLR4 signal pathway

Author:: Weiwei Li; Rui Huang; Xia Gong; Zizuo Zhao; Lidan Zhang; Qin Zhou; Xujie Jiang; Hongtao Tie; Jingyuan Wan; Bin Wang
Source:: Food & function 2022 v.13 no.13 pp. 7361-7376
ISSN:: 2042-650X
Subject:: Western blotting; allicin; apoptosis; blood; dose response; drugs; garlic; histology; ischemia; liver; liver function; mechanism of action; models; morbidity; mortality; necrosis; neoplasms; oxidative stress; peroxisome proliferator-activated receptor gamma; protective effect; reperfusion injury; signal transduction; surgery
Abstract:: ... Background: Hepatic ischemia/reperfusion (I/R) injury to the liver is a significant cause of morbidity and mortality following liver surgery, trauma, and hemorrhagic shock. It was reported that allicin, a type of garlic compound, had a protective effect against other hepatic diseases. Allicin's ability to protect against liver injury caused by ischemic reperfusion remains unknown. As a result, we ...
DOI:: 10.1039/d2fo00751g
: https://doi.org/10.1039/d2fo00751g

60. Aloe emodin 3-O-glucoside inhibits cell growth and migration and induces apoptosis of non-small-cell lung cancer cells via suppressing MEK/ERK and Akt signalling pathways

Author:: Hyeon Jeong Kim; Ji Won Choi; Jin Ree; Jung Sik Lim; Jisun Lee; Jun Il Kim; Samir Bahadur Thapa; Jae Kyung Sohng; Yong Il Park
Source:: Life sciences 2022 v.300 pp. 120495
ISSN:: 0024-3205
Subject:: Aloe; DNA fragmentation; Western blotting; antineoplastic activity; apoptosis; caspase-9; cell growth; cell movement; cytotoxicity; emodin; glycosylation; histopathology; humans; intraperitoneal injection; lung neoplasms; membrane potential; mitochondrial membrane; mortality; neoplasm cells; water solubility; xenotransplantation
Abstract:: ... Non-small-cell lung cancer (NSCLC) is the most frequent type of lung cancer with a high mortality rate. Glycosylation of phenolic compounds may increase water-solubility and pharmacological activities and reduce the toxicity of aglycones. This study aimed to evaluate and compare the anticancer effect of aloe emodin 3-O-glucoside (AE3G) and its aglycone, aloe emodin (AE), against NSCLC. A human ade ...
DOI:: 10.1016/j.lfs.2022.120495
: https://doi.org/10.1016/j.lfs.2022.120495

61. Alpha-linolenic acid inhibits hepatocellular carcinoma cell growth through Farnesoid X receptor/β-catenin signaling pathway

Author:: Shu Feng; Xingming Xie; Chaochun Chen; Shi Zuo; Xueke Zhao; Haiyang Li
Source:: Nutrition & metabolism 2022 v.19 no.1 pp. 57
ISSN:: 1743-7075
Subject:: Western blotting; acid treatment; alpha-linolenic acid; cell growth; gas chromatography; hepatoma; lipid composition; migratory behavior; neoplasm cells; nutrition; protein synthesis; spectrometers
Abstract:: ... BACKGROUND: Altered lipid profiles are frequently present in cancer, and it is necessary to elucidate the role of changed lipid profiles in hepatocellular carcinoma (HCC). We conducted this study to investigate the changed lipid profile in HCC tissues and discover some remarkably changed lipid components, and to explore the function of changed lipid components in HCC development. METHODS: Gas chro ...
DOI:: 10.1186/s12986-022-00693-1
: https://doi.org/10.1186/s12986-022-00693-1

62. Alpinae Oxyphyllae Fructus alleviated LPS‐induced cognitive impairments via PI3K/AKT/NF‐κB signaling pathway

Author:: Tingxu Yan; Xiaozhuo Zhang; Qianqian Mao; Bo Wu; Bosai He; Ying Jia; Lei Shang
Source:: Environmental toxicology 2022 v.37 no.3 pp. 489-503
ISSN:: 1520-4081
Subject:: Western blotting; cognition; cortex; ecotoxicology; interleukin-6; lipopolysaccharides; memory; memory disorders; phosphatidylinositol 3-kinase
Abstract:: ... Herein, we aim to investigate the effect of Alpinae Oxyphyllae Fructus (AOF) on cognitive impairments and neuroinflammation in a lipopolysaccharide (LPS)‐induced models of AD. Mice were injected intracerebroventricularly with LPS, and then administrated AOF using a gavage for 6 weeks. Spatial working memory was assessed using the Y‐maze and Morris water maze test, whereas the levels of PI3K, AKT, ...
DOI:: 10.1002/tox.23415
: https://doi.org/10.1002/tox.23415

63. Alteration of LncRNA expression in mice placentae after frozen embryo transfer is associated with increased fetal weight

Author:: Yuan Zhu; Yunni Cai; Bo Zheng; Min Ding; Yuting Zhang; Jianjun Zhou
Source:: Reproductive Biology 2022 v.22 no.2 pp. 100646
ISSN:: 1642-431X
Subject:: Western blotting; birth weight; blastocyst; embryo transfer; mice; microRNA; morphogenesis; sequence analysis; superovulation
Abstract:: ... The birthweight after frozen embryo transfer (FET) was significantly higher compared with fresh embryo transfer (fresh ET), while the mechanism remains unclear. In this study, we transferred vitrified-warmed or fresh mice blastocysts into pseudopregnant recipients (n = 11 each group) produced by natural mating to avoid the influence of superovulation. The fetal weight, placental weight, placental ...
DOI:: 10.1016/j.repbio.2022.100646
: https://doi.org/10.1016/j.repbio.2022.100646

64. The Alterations and Significance of Intercellular Adhesion Molecule-1 in Mouse Brainstem During Herpes Simplex Virus Type 1–Induced Facial Palsy

Author:: Hong Mu; Junjie Liu; Yanyan Mao; Yuechen Han; Lei Xu; Daogong Zhang; Haibo Wang
Source:: Applied biochemistry and biotechnology 2022 v.194 no.8 pp. 3483-3493
ISSN:: 0273-2289
Subject:: Human alphaherpesvirus 1; Western blotting; animal models; biotechnology; brain stem; face; genes; glucocorticoids; herpes simplex; intercellular adhesion molecule-1; males; methylprednisolone; mice; nerve tissue; paralysis; pathophysiology; protein synthesis; quantitative polymerase chain reaction; viruses
Abstract:: ... Herpes simplex virus type 1 (HSV-1) results in the development of Bell’s pals but still, the pathophysiology of the facial nerve paralysis is still not fully studied. The main objective is to establish an animal model of type 1 herpes simplex virus (HSV-1)–induced face paralysis in the mouse and to investigate the pattern of changes in intercellular adhesion molecule -1(ICAM-1) expression in the f ...
DOI:: 10.1007/s12010-022-03837-4
: https://doi.org/10.1007/s12010-022-03837-4

65. Alterations in connexin 43 gene and protein expression in the chicken oviduct following tamoxifen treatment

Author:: Anna Hrabia; Dominika Wolak; Kinga Kowalik; Andrzej Sechman
Source:: Theriogenology 2022 v.188 pp. 125-134
ISSN:: 0093-691X
Subject:: Western blotting; body weight; connexins; eggs; estrogen receptors; estrogens; fluorescent antibody technique; gap junctions; gene expression; genes; immune response; muscle contraction; muscles; oogenesis; oviducts; oviposition; poultry production; protein synthesis; quantitative polymerase chain reaction; shell gland; tamoxifen; vagina
Abstract:: ... Connexins (Cxs) are a group of gap junction proteins involved in the direct exchange of small molecules between neighboring cells. Information concerning the expression and regulation of Cxs in the chicken oviduct is lacking, but likely has potential implications for functioning of the oviduct and the quality of the egg laid by commercially used hens. The present study was designed to examine whet ...
DOI:: 10.1016/j.theriogenology.2022.06.001
: https://doi.org/10.1016/j.theriogenology.2022.06.001

66. Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington’s disease mice

Author:: Anika Pupak; Ankita Singh; Anna Sancho-Balsells; Rafael Alcalá-Vida; Marc Espina; Albert Giralt; Eulàlia Martí; Ulf Andersson Vang Ørom; Silvia Ginés; Verónica Brito
Source:: Cellular and molecular life sciences 2022 v.79 no.8 pp. 416
ISSN:: 1420-682X
Subject:: RNA; Western blotting; cognition; demethylation; fractionation; hippocampus; memory; methylation; methyltransferases; precipitin tests; synapse; transcriptome
Abstract:: ... N6-methyladenosine (m6A) regulates many aspects of RNA metabolism and is involved in learning and memory processes. Yet, the impact of a dysregulation of post-transcriptional m6A editing on synaptic impairments in neurodegenerative disorders remains unknown. Here we investigated the m6A methylation pattern in the hippocampus of Huntington’s disease (HD) mice and the potential role of the m6A RNA m ...
DOI:: 10.1007/s00018-022-04444-6
: https://doi.org/10.1007/s00018-022-04444-6

67. Amelioration of lipid accumulations and metabolism disorders in differentiation and development of 3T3-L1 adipocytes through mulberry leaf water extract

Author:: Yan Du; Ding-xiang Li; Dong-yu Lu; Ran Zhang; Qiao-qiao Zhong; Yan-lin Zhao; Xiao-xiao Zheng; Shuai Ji; Liang Wang; Dao-Quan Tang
Source:: Phytomedicine 2022 v.98 pp. 153959
ISSN:: 0944-7113
Subject:: AMP-activated protein kinase; Oriental traditional medicine; Western blotting; acetyl-CoA carboxylase; adipocytes; adiponectin; adiponectin receptors; adipose tissue; arachidonic acid; biosynthesis; carboxylic ester hydrolases; fatty-acid synthase; glycerol; glycerophospholipids; high performance liquid chromatography; inflammation; interleukin-10; interleukin-6; leaves; metabolites; metabolomics; molecular biology; mulberries; obesity; quantitative polymerase chain reaction; sterols; tandem mass spectrometry
Abstract:: ... Obesity is a worldwide problem that resulted from the excessive fat accumulation in adipose tissue, leading to the impairment of individual health. Mulberry leaf is an important traditional Chinese medicine and has been used to alleviate obesity for a long term. However, its underlying molecular mechanisms have not been fully elucidated yet. In this study, we aimed to investigate the inhibition ef ...
DOI:: 10.1016/j.phymed.2022.153959
: https://doi.org/10.1016/j.phymed.2022.153959

68. Amelioration of oxidative stress by trans-Anethole via modulating phase I and phase II enzymes against hepatic damage induced by CCl4 in male Wistar rats

Author:: Kritika Pandit; Ajay Kumar; Sandeep Kaur; Vinod Kumar; Subheet Kumar Jain; Renu Bhardwaj; Satwinderjeet Kaur
Source:: Environmental science and pollution research 2022 v.29 no.4 pp. 6317-6333
ISSN:: 0944-1344
Subject:: Western blotting; alanine transaminase; alkaline phosphatase; anise; aspartate transaminase; aspartic acid; bilirubin; blood serum; body weight; carbon tetrachloride; caspase-3; catalase; cyclins; glutathione-disulfide reductase; histopathology; liver; males; olive oil; oxidative stress; pollution; research; silymarin
Abstract:: ... The current study was designed to assess the in vivo hepatoprotective properties of trans-Anethole, which is a principal aromatic component of star anise. The hepatoprotective effects of trans-Anethole were evaluated at three doses [40, 80, and 160 mg/kg body weight (b.wt.)] against carbon tetrachloride (CCl₄)-induced hepatic damage in male Wistar rats for 4 weeks. Forty-two male Wistar rats were ...
DOI:: 10.1007/s11356-021-16070-z
: https://doi.org/10.1007/s11356-021-16070-z

69. Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis

Author:: Rongchun Wang; Qingyu Ren; Daili Gao; Yam Nath Paudel; Xia Li; Lizhen Wang; Pengyu Zhang; Baokun Wang; Xueliang Shang; Meng Jin
Source:: Journal of ethnopharmacology 2022 v.289 pp. 115018
ISSN:: 0378-8741
Subject:: Danio rerio; Gastrodia elata; Oriental traditional medicine; Western blotting; adults; antidepressants; apoptosis; cell viability; diet; fluorescent antibody technique; gene expression; models; pharmacology; protein synthesis; China
Abstract:: ... Gastrodia elata Blume (G. elata), a traditional Chinese herb, known as “Tian Ma”, is widely used as a common medicine and diet ingredient for treating or preventing neurological disorders for thousands of years in China. However, the anti-depressant effect of G. elata and the underlying mechanism have not been fully evaluated. The study is aimed to investigate the anti-depressant effect and the mo ...
DOI:: 10.1016/j.jep.2022.115018
: https://doi.org/10.1016/j.jep.2022.115018

70. Ameliorative effect of the ethnomedicinal plant Blepharis maderaspatensis (L.) B.Heyne ex Roth on lipopolysaccharide-induced acute liver inflammation and oxidative stress in Wistar rat model

Author:: Thadiyan Parambil Ijinu; Kuttapetty Manikantan; Ajayakumar Lalitha Aneeshkumar; Vijayan Soorya; Panickamparambil Gopalakrishnan Latha; Varughese George; Palpu Pushpangadan
Source:: Phytomedicine plus 2022 v.2 no.2 pp. 100247
ISSN:: 2667-0313
Subject:: Blepharis; Western blotting; acute oral toxicity; albino; aluminum chloride; animal models; antioxidants; blood serum; body weight; drugs; gene expression; guidelines; hematology; histopathology; inflammation; interleukin-6; liver; medicine; oxidative stress; phosphorylation; protective effect; silymarin; thin layer chromatography; India
Abstract:: ... Blepharis maderaspatensis is an ethnomedicinal plant used by the Mavilan and Koraga tribes of Kerala state, India for the treatment of liver diseases. Thus, the present study aims to evaluate the liver protective activity of defatted ethanolic extract of B. maderaspatensis on lipopolysaccharide-induced acute liver inflammation and oxidative stress in Wistar rat model. Preliminary phytochemical eva ...
DOI:: 10.1016/j.phyplu.2022.100247
: https://doi.org/10.1016/j.phyplu.2022.100247

71. Amentoflavone impairs the reconsolidated fear memories through inhibition of ERK pathway

Author:: Kuisheng Sun; Ruizhu Xie; Zhengjun Yi; Liqian Yin; Yan Guan; Lujuan Wang; Ying Wang; Xiaoyan Ding; Yaning Luan; Huijie Liu; Yuhan Fan
Source:: Biochemical and biophysical research communications 2022 v.622 pp. 8-14
ISSN:: 0006-291X
Subject:: Western blotting; amygdala; animal behavior; fearfulness; inflammation; memory; pathophysiology; research
Abstract:: ... Post-traumatic stress disorder (PTSD) is a pathological fear memory-related disease. The persistence of pathological fearful memories is one of the most characteristic symptoms of PTSD. However, this can be eliminated by intervening in reconsolidation. Inflammation is intimately involved in the pathophysiologic progression of PTSD. Amentoflavone (AF) has anti-inflammatory effects. However, the eff ...
DOI:: 10.1016/j.bbrc.2022.07.024
: https://doi.org/10.1016/j.bbrc.2022.07.024

72. Analgesic and antiinflammatory effects of Nigella orientalis L. seeds fixed oil: Pharmacological potentials and molecular mechanisms

Author:: Djedjiga Ait Eldjoudi; Clara Ruiz‐Fernandez; María González‐Rodriguez; Sihem Ait Atmane; Alfonso Cordero‐Barreal; Yousof Farrag; Jesus Pino; Jorge Sineiro; Francisca Lago; Javier Conde‐Aranda; Bachra Khettal; Oreste Gualillo
Source:: Phytotherapy research 2022 v.36 no.3 pp. 1372-1385
ISSN:: 0951-418X
Subject:: Nigella; Western blotting; acetic acid; analgesic effect; analgesics; anti-inflammatory activity; cell viability; ears; edema; erythrocyte membrane; genes; macrophages; mechanism of action; mitogen-activated protein kinase; nitric oxide; oils; phytotherapy; prostaglandins; protein synthesis; research; toxicity testing; traditional medicine
Abstract:: ... Nigella species have been widely used in traditional medicine. The aim of this study was to evaluate the antiinflammatory and analgesic potentials of Nigella orientalis L. seeds fixed oil (NOO). The acetic acid writhing test and the formaldehyde‐induced licking paw were performed to assess the analgesic activity of the oil. The antiinflammatory activity was first evaluated in vitro by the erythroc ...
DOI:: 10.1002/ptr.7400
: https://doi.org/10.1002/ptr.7400

73. Analyses on the Infection Process of Rice Virus and the Spatiotemporal Expression Pattern of Host Defense Genes Based on a Determined-Part Inoculation Approach

Author:: Wei Guo; Chenyang Li; Bo Zeng; Jie Li; Zhaoyun Wang; Shuhui Ma; Linlin Du; Ying Lan; Feng Sun; Chengye Lu; Shuo Li; Yijun Zhou; Yunyue Wang; Tong Zhou
Source:: Pathogens 2022 v.11 no.2 pp. -
ISSN:: 2076-0817
Subject:: Rice black streaked dwarf virus; Rice stripe tenuivirus; Western blotting; crop yield; cultivars; genes; inoculation methods; leaves; quantitative polymerase chain reaction; rice; viruses
Abstract:: ... Rice viral diseases adversely affect crop yield and quality. Most rice viruses are transmitted through insect vectors. However, the traditional whole-plant inoculation method cannot control the initial inoculation site in rice plants because the insect feeding sites in plants are random. To solve this problem, we established a determined-part inoculation approach in this study that restricted the ...
DOI:: 10.3390/pathogens11020144
: https://doi.org/10.3390/pathogens11020144

74. Analysis of the resistance of small peptides from Periplaneta americana to hydrogen peroxide-induced apoptosis in human ovarian granular cells based on RNA-seq

Author:: Qin Wang; Rong Fu; Honghan Cheng; Yi Li; Shiyan Sui
Source:: Gene 2022 v.813 pp. 146120
ISSN:: 0378-1119
Subject:: 4',6-diamidino-2-phenylindole; Periplaneta americana; RNA transport; Western blotting; apoptosis; caspase-3; fluorescence; gene expression regulation; genes; humans; hydrogen peroxide; interleukin-17; leukocytes; quantitative polymerase chain reaction; sequence analysis; transcriptome
Abstract:: ... Apoptosis of ovarian granular cells is closely related with weakening fertility of women. Hence, resisting apoptosis of human ovarian granular cells is of important significance. According to previous studies, DAPI fluorescence staining experiment and Western Blot test of Caspase-3 demonstrate that small peptides from Periplaneta americana (SPPA) can improve hydrogen peroxide (H₂O₂) -induced apopt ...
DOI:: 10.1016/j.gene.2021.146120
: https://doi.org/10.1016/j.gene.2021.146120

75. Andrograpanin mitigates lipopolysaccharides induced endometritis via TLR4/NF-κB pathway

Author:: Baoyi Yin; Talha Umar; Xiaofei Ma; Yu Chen; Zaima Umar; Saqib Umer; Ganzhen Deng
Source:: Reproductive Biology 2022 v.22 no.1 pp. 100606
ISSN:: 1642-431X
Subject:: Andrographis paniculata; Western blotting; anti-inflammatory activity; cattle; cytotoxicity; endometritis; endometrium; epithelium; fluorescent antibody technique; histopathology; inflammation; interleukin-6; lipopolysaccharides; mice; phosphorylation; protein content; therapeutics
Abstract:: ... Endometritis is an inflammatory disease that is caused by various pathogenic organisms. Andrograpanin is a compound of Andrographis paniculata, which has an important role in many inflammatory diseases, but the molecular mechanism of andrograpanin to combat inflammation is unclear. This study shows the anti-inflammatory effect of andrograpanin on Lipopolysaccharides (LPS) stimulated bovine endomet ...
DOI:: 10.1016/j.repbio.2022.100606
: https://doi.org/10.1016/j.repbio.2022.100606

76. Anemoside B4 prevents chronic obstructive pulmonary disease through alleviating cigarette smoke-induced inflammatory response and airway epithelial hyperplasia

Author:: Huimiao Ma; Ziye Zhou; Lanying Chen; Lingling Wang; Qi Muge
Source:: Phytomedicine 2022 v.107 pp. 154431
ISSN:: 0944-7113
Subject:: Anemone chinensis; Western blotting; catalase; cell viability; cigarettes; epithelium; glutathione peroxidase; humans; hyperplasia; inflammation; ingredients; interleukin-8; lung function; lung neoplasms; lungs; malondialdehyde; medicinal plants; mice; models; oxidative stress; protein synthesis; proteinases; reactive oxygen species; risk; smoke; stress response; superoxide dismutase; therapeutics
Abstract:: ... Cigarette smoke (CS) is one of the major risk factors for chronic obstructive pulmonary disease (COPD) and increases the risk of lung cancer (LC). Anemoside B4 (B4) is the main bioactive ingredient in Pulsatilla chinensis (P. chinensis), a traditional medicinal herb for various diseases. It has a wide range of anti-inflammatory, anti-oxidation and anti-cancer activities. However, in recent years, ...
DOI:: 10.1016/j.phymed.2022.154431
: https://doi.org/10.1016/j.phymed.2022.154431

77. Angelol-A exerts anti-metastatic and anti-angiogenic effects on human cervical carcinoma cells by modulating the phosphorylated-ERK/miR-29a-3p that targets the MMP2/VEGFA axis

Author:: Tsung-Ho Ying; Chia-Liang Lin; Pei-Ni Chen; Pei-Ju Wu; Chung-Jung Liu; Yi-Hsien Hsieh
Source:: Life sciences 2022 v.296 pp. 120317
ISSN:: 0024-3205
Subject:: Angelica pubescens; Western blotting; angiogenesis; cell cycle; cell movement; chemotaxis; coumarins; flow cytometry; humans; metastasis; toxicity testing; uterine cervical neoplasms; viability
Abstract:: ... Angelol-A (Ang-A), a kind of coumarins, is isolated from the roots of Angelica pubescens f. biserrata. However, AA exerts antitumor effects and molecular mechanism on cervical cancer cells is unknown. Cell viability was determined using the MTT assay, and the cell cycle phase was assessed by PI staining with flow cytometry. Ang-A-treated cells with/without Antago-miR-29a-3p (miR-29a-3p inhibitor) ...
DOI:: 10.1016/j.lfs.2022.120317
: https://doi.org/10.1016/j.lfs.2022.120317

78. Angiotensin II can trigger HSC-LX2 pyroptosis through both classical and non-classical pathways

Author:: Ze-yu Xie; Yi-xiao Xu; Li Yao
Source:: Life sciences 2022 v.307 pp. 120878
ISSN:: 0024-3205
Subject:: Western blotting; cell proliferation; cell viability; gene expression; humans; interleukin-18; liver cirrhosis; pyroptosis; therapeutics
Abstract:: ... Current evidence suggests that liver fibrosis is reversible even at late stages. Pyroptosis is reportedly regulated by classical and non-classical pathways and is also involved in the activation of the human hepatic stellate cell line LX2. This study sought to identify regulatory pathways that pyroptosis of HSC during AngII-ROS-induced HSC activation and provides novel insights for anti-fibrosis t ...
DOI:: 10.1016/j.lfs.2022.120878
: https://doi.org/10.1016/j.lfs.2022.120878

79. Angiotensin-(1–7) promotes mitochondrial translocation of human telomerase reverse transcriptase in HUVECs through the TOM20 complex

Author:: Weikai Hu; Yinan Guo; Xueyan Wang; Tianyu Cui; Chunyun Li; Ruixia Liu; Chenghong Yin
Source:: Archives of biochemistry and biophysics 2022 v.722 pp. 109218
ISSN:: 0003-9861
Subject:: Western blotting; antagonists; biophysics; fluorescent antibody technique; gene expression; humans; inflammation; lipopolysaccharides; mitochondria; models; peptides; protein content; protein synthesis; reverse transcriptase polymerase chain reaction; telomerase; transfection
Abstract:: ... Angiotensin (Ang) (1–7) is a vasodilator peptide that ameliorates microcirculation dysfunction, increases telomerase activity in cells, and exerts vasodilatory, anti-inflammatory, antioxidative stress, and antiapoptotic effects. Mitochondrial human telomerase reverse transcriptase (hTERT) plays an important role in the processes of antiapoptosis, antioxidative stress, and immortalization. This stu ...
DOI:: 10.1016/j.abb.2022.109218
: https://doi.org/10.1016/j.abb.2022.109218

80. Annual changes in cell proliferation and apoptosis and expression of connexin 43 in the testes of domestic seasonal breeding ganders

Author:: Małgorzata Gumułka; Anna Hrabia; Israel Rozenboim
Source:: Theriogenology 2022 v.186 pp. 27-39
ISSN:: 0093-691X
Subject:: Western blotting; animal reproduction; apoptosis; caspase-3; cell proliferation; connexins; epithelium; fluorometry; ganders; gap junctions; gene expression; genes; histology; morphometry; testes
Abstract:: ... Molecular mechanisms of seasonal changes in testicular morphology, histoarchitecture, and functions in birds have not been fully elucidated. The aim of the study was to examine the alternations in cell proliferation and apoptosis, these processes-related gene expressions, and gap junction protein (GJA1gene, connexin 43 protein; Cx43) expression and localization in gander testes during annual stage ...
DOI:: 10.1016/j.theriogenology.2022.03.031
: https://doi.org/10.1016/j.theriogenology.2022.03.031

81. Antagonistic Effect of Selenium on Fumonisin B1 Promotes Neutrophil Extracellular Traps Formation in Chicken Neutrophils

Author:: Huquan Zhu; Qinfang Yu; Huimin Ouyang; Ruofan Zhang; Jinhong Li; Runxi Xian; Kai Wang; Xinran Li; Changyu Cao
Source:: Journal of agricultural and food chemistry 2022 v.70 no.19 pp. 5911-5920
ISSN:: 1520-5118
Subject:: DNA; Western blotting; chickens; drugs; elastase; fluorescence; fluorescence microscopy; food chemistry; fumonisin B1; gene expression; genes; glutathione peroxidase; histones; innate immunity; mechanism of action; neutrophils; protein synthesis; quantitative polymerase chain reaction; reactive oxygen species; selenoproteins; thioredoxins; toxicity
Abstract:: ... Neutrophils are an important component of the innate immune system, and one of their defense mechanisms, neutrophil extracellular traps (NETs), is a hot topic of the current research. This study explored the effects of fumonisin B1 (FB1) on chicken neutrophil production of NETs and its possible molecular mechanism of action. Scanning electron microscopy and fluorescence microscopy were used to obs ...
DOI:: 10.1021/acs.jafc.2c01329
: https://doi.org/10.1021/acs.jafc.2c01329

82. Antagonistic effects of selenium on lead-induced oxidative stress and apoptosis of Leydig cells in sheep

Author:: Lei Shi; Xiaolei Wang; Yunli Duan; Kexin Li; Youshe Ren
Source:: Theriogenology 2022 v.185 pp. 43-49
ISSN:: 0093-691X
Subject:: Western blotting; animal reproduction; apoptosis; caspase-3; caspase-8; cell proliferation; cell viability; gene expression; lead; oxidative stress; quantitative polymerase chain reaction; selenium; sheep
Abstract:: ... The objective of this study was to investigate the antagonistic effects of selenium (Se) on lead (Pb)-induced oxidative stress and apoptosis of sheep Leydig cells and its underlying mechanism. Leydig cells collected from 8-month-old sheep were treated with Pb (40 μmol/L) and/or Se (2 μmol/L), respectively. CCK-8 assay was used to detect cell proliferation and apoptosis after cultured for 48 h. The ...
DOI:: 10.1016/j.theriogenology.2022.03.023
: https://doi.org/10.1016/j.theriogenology.2022.03.023

83. Antarctic krill peptides improve scopolamine-induced memory impairment in mice

Author:: Jingru Zheng; Yuanhong Gao; Jie Ding; Na Sun; Songyi Lin
Source:: Food bioscience 2022 v.49 pp. 101987
ISSN:: 2212-4292
Subject:: Euphausia superba; Western blotting; blood serum; caspase-3; memory disorders; mice; peptides; scopolamine
Abstract:: ... The study aims to investigate the repair effects of Ser-Ser-Asp-Ala-Phe-Phe-Pro-Phe-Arg (SSDAFFPFR) and Ser-Asn-Val-Phe-Asp-Met-Phe (SNVFDMF) peptides on scopolamine-caused memory impairment in mice. Behavioral experiments have revealed that Antarctic krill peptides can ameliorate scopolamine caused memory impairment by changing the behavior of mice. In comparison with the scopolamine group, the t ...
DOI:: 10.1016/j.fbio.2022.101987
: https://doi.org/10.1016/j.fbio.2022.101987

84. Anti-Colon Cancer Activity of Novel Peptides Isolated from In Vitro Digestion of Quinoa Protein in Caco-2 Cells

Author:: Xin Fan; Huimin Guo; Cong Teng; Biao Zhang; Christophe Blecker; Guixing Ren
Source:: Foods 2022 v.11 no.2 pp. -
ISSN:: 2304-8158
Subject:: Western blotting; antineoplastic activity; carcinogenesis; colorectal neoplasms; digestion; histone deacetylase; interleukin-6; interleukin-8; liquid chromatography; protein hydrolysates; quantitative polymerase chain reaction; tandem mass spectrometry
Abstract:: ... Quinoa peptides are the bioactive components obtained from quinoa protein digestion, which have been proved to possess various biological activities. However, there are few studies on the anticancer activity of quinoa peptides, and the mechanism has not been clarified. In this study, the novel quinoa peptides were obtained from quinoa protein hydrolysate and identified by liquid chromatography–tan ...
DOI:: 10.3390/foods11020194
: https://doi.org/10.3390/foods11020194

85. Anti-Inflammatory Activity and Mechanism of Cryptochlorogenic Acid from Ageratina adenophora

Author:: Xiaoping Ma; Samuel Kumi Okyere; Liwen Hu; Juan Wen; Zhihua Ren; Junliang Deng; Yanchun Hu
Source:: Nutrients 2022 v.14 no.3 pp. -
ISSN:: 2072-6643
Subject:: Ageratina adenophora; Western blotting; anti-inflammatory activity; cytotoxicity; enzyme-linked immunosorbent assay; inflammation; interleukin-6; interleukin-8; invasive species; lipopolysaccharides; livestock; mechanism of action; nitric oxide; phosphorylation; prostaglandin synthase; reverse transcriptase polymerase chain reaction; transcription factor NF-kappa B
Abstract:: ... Ageratina adenophora is an invasive plant known for its toxicity to livestock. Current research on this plant has shifted from toxicity prevention to the beneficial utilization of plant resources. This study was performed to investigate the effects and mechanisms of cryptochlorogenic acid (CCGA) isolated from Ageratina adenophora on the inflammatory responses induced by lipopolysaccharide (LPS) in ...
DOI:: 10.3390/nu14030439
: https://doi.org/10.3390/nu14030439

86. Anti-Inflammatory Activity of Orally Administered Monostroma nitidum Rhamnan Sulfate against Lipopolysaccharide-Induced Damage to Mouse Organs and Vascular Endothelium

Author:: Masahiro Terasawa; Keiichi Hiramoto; Ryota Uchida; Koji Suzuki
Source:: Marine drugs 2022 v.20 no.2 pp. -
ISSN:: 1660-3397
Subject:: Monostroma; Western blotting; anti-inflammatory activity; blood circulation; caudal vein; endothelium; humans; immunohistochemistry; inflammation; jejunum; lipopolysaccharides; liver; lungs; mice; neutrophils; sulfates; syndecans
Abstract:: ... We previously reported that rhamnan sulfate (RS) purified from Monostroma nitidum significantly suppressed lipopolysaccharide (LPS)-induced inflammation in cultured human vascular endothelial cells. Here, we analyzed the effect of orally administered RS on LPS-induced damage to mouse organs and vascular endothelium. RS (1 mg) was orally administered daily to BALB/c mice, 50 μg of LPS was intraperi ...
DOI:: 10.3390/md20020121
: https://doi.org/10.3390/md20020121

87. Anti-L1 antibody-bound HPV16 pseudovirus is degraded intracellularly via TRIM21/proteasomal pathway

Author:: Meiying Li; Jianmei Huang; Yi Zhu; Ziyi Huang; Guonan Zhang; Jianming Huang
Source:: Virology journal 2022 v.19 no.1 pp. 90
ISSN:: 1743-422X
Subject:: Pseudovirus; Western blotting; antibodies; bioluminescence assay; coat proteins; cytokines; cytosol; epithelium; flow cytometry; fluorescence microscopy; plasmids; proteasome endopeptidase complex; risk factors; transfection; uterine cervical neoplasms; virology; viruses
Abstract:: ... BACKGROUND: Persistent HPV16 infection is the leading risk factor for developing cervical cancer. Anti-L1 antibodies against HPV16 produced in HPV16 infections play diverse roles in the clearance of virus infection and prevention of persistence. It has been implicated that the cervicovaginal squamous epithelial cells actually express TRIM21 and that some HPV16 particles could escape leaky endosoma ...
DOI:: 10.1186/s12985-022-01826-x
: https://doi.org/10.1186/s12985-022-01826-x

88. Anti-Parkinsonian effect of Mucuna pruriens and Ursolic acid on GSK3β/Calcium signaling in neuroprotection against Rotenone-induced Parkinsonism

Author:: Walia Zahra; Hareram Birla; Saumitra Sen Singh; Aaina Singh Rathore; Hagera Dilnashin; Richa Singh; Priyanka Kumari Keshri; Shekhar Singh; Surya Pratap Singh
Source:: Phytomedicine plus 2022 v.2 no.4 pp. 100343
ISSN:: 2667-0313
Subject:: Mucuna pruriens; Parkinson disease; Western blotting; apoptosis; calcium; death; eukaryotic cells; glycogen (starch) synthase; homeostasis; immunohistochemistry; mice; mitochondria; models; neuroprotective effect; oxidative stress; pathogenesis; protein kinases; protein synthesis; rotenone; serine; threonine; toxins; ursolic acid
Abstract:: ... Exposure of environmental toxin is linked to the onset of Parkinson's disease (PD), especially in majority of sporadic cases. One of such toxins, namely Rotenone has been widely investigated to produce the Parkinsonian model in laboratories. The toxin causes the death of the dopaminergic neurons, aggregation of α-Synuclein, oxidative stress, neuroinflammation and initiate other pathways leading to ...
DOI:: 10.1016/j.phyplu.2022.100343
: https://doi.org/10.1016/j.phyplu.2022.100343

89. Anti-VEGF Effect of Bioactive Indolic Compounds and Hydroxytyrosol Metabolites

Author:: Marta Gallardo-Fernández; Ana B. Cerezo; Ruth Hornedo-Ortega; Ana M. Troncoso; M. Carmen Garcia-Parrilla
Source:: Foods 2022 v.11 no.4 pp. -
ISSN:: 2304-8158
Subject:: Western blotting; angiogenesis; bioactive properties; endothelial nitric oxide synthase; indoles; metabolites; phosphorylation; pyruvic acid; vascular endothelial growth factor receptor-2; vascular endothelial growth factors
Abstract:: ... Angiogenesis is a key process involved in both cancer and cardiovascular diseases, the vascular endothelial growth factor (VEGF) and its VEGF receptor-2 (VEGFR-2) being the main triggers. The aim of this study was to determine the molecular mechanism underlying the potent inhibition of VEGF signaling by hydroxytyrosol (HT) metabolites and indolic compounds and establish a relation between their st ...
DOI:: 10.3390/foods11040526
: https://doi.org/10.3390/foods11040526

90. Anti-angiogenic effect of YuXueBi tablet in experimental rheumatoid arthritis by suppressing LOX/Ras/Raf-1 signaling

Author:: Xiaohui Su; Bei Yuan; Xueying Tao; Wanyi Guo; Xia Mao; Anguo Wu; Qian Wang; Chunfang Liu; Yanqiong Zhang; Xiangying Kong; Lan Han; Na Lin
Source:: Journal of ethnopharmacology 2022 v.298 pp. 115611
ISSN:: 0378-8741
Subject:: Oriental traditional medicine; Western blotting; angiogenesis; disease severity; hyperplasia; immunohistochemistry; mechanism of action; methotrexate; micro-computed tomography; pharmacology; phosphorylation; rheumatoid arthritis; therapeutics; transcription (genetics)
Abstract:: ... A Chinese patent medicine derived from a classical traditional Chinese medicine formula, Yu-Xue-Bi tablet (YXB) is widely used in the clinic to treat rheumatoid arthritis (RA). During the progression of RA, angiogenesis plays a central role in fostering the production of inflammatory cells, leading to synovial hyperplasia and bone destruction. However, whether YXB attenuates the angiogenesis durin ...
DOI:: 10.1016/j.jep.2022.115611
: https://doi.org/10.1016/j.jep.2022.115611

91. Anti-atherosclerotic effects of geraniin through the gut microbiota-dependent trimethylamine N-oxide (TMAO) pathway in mice

Author:: Kaiyang Lin; Xuedong Wang; Ji Li; Peng Zhao; Xiangwen Xi; Yi Feng; Li Yin; Jinwei Tian; Hulun Li; Xinxin Liu; Bo Yu
Source:: Phytomedicine 2022 v.101 pp. 154104
ISSN:: 0944-7113
Subject:: Bacteroides; Firmicutes; Western blotting; atherosclerosis; colon; death; drugs; gene expression regulation; interleukin-10; interleukin-6; intestinal microorganisms; macrophages; medicinal properties; polyphenols; proteomics; risk reduction; transmembrane proteins; trimethylamine
Abstract:: ... Cardiovascular disease is a leading cause of death, which signifies the urgent need for effective anti-atherosclerotic strategies. Gut microbiota-dependent trimethylamine-N-oxide (TMAO) is associated with atherosclerosis, and geraniin, a natural polyphenol with various biological activities, might play key role in this process. We aimed to investigate the pharmacological activity of geraniin in at ...
DOI:: 10.1016/j.phymed.2022.154104
: https://doi.org/10.1016/j.phymed.2022.154104

92. Anti-infection roles of miR-155-5p packaged in exosomes secreted by dendritic cells infected with Toxoplasma gondii

Author:: Dan Jiang; Shuizhen Wu; Liqing Xu; Guantai Xie; Dongliang Li; Hongjuan Peng
Source:: Parasites & vectors 2022 v.15 no.1 pp. 3
ISSN:: 1756-3305
Subject:: Protozoa; Toxoplasma gondii; Western blotting; cell communication; exosomes; genes; interleukin-6; macrophages; mice; pregnancy; secretion; tachyzoites; toxoplasmosis; transmission electron microscopy; ultracentrifugation
Abstract:: ... BACKGROUND: Toxoplasma gondii is a zoonotic intracellular protozoon that is estimated to infect about 30% of the world’s population, resulting in toxoplasmosis in immunocompromised patients and adverse outcomes in cases of primary infection during pregnancy. Exosomes are tubular vesicles secreted by cells, and function in intercellular communication. It has been reported that the exosomes secreted ...
DOI:: 10.1186/s13071-021-05003-x
: https://doi.org/10.1186/s13071-021-05003-x

93. Anti-inflammatory activity of Anchusa italica Retz. in LPS-stimulated RAW264.7 cells mediated by the Nrf2/HO-1, MAPK and NF-κB signaling pathways

Author:: Xiaomei Duan; Jun Li; Jingxue Cui; Yuwei Dong; Xuelei Xin; Haji Akber Aisa
Source:: Journal of ethnopharmacology 2022 v.286 pp. 114899
ISSN:: 0378-8741
Subject:: Anchusa azurea; Western blotting; anti-inflammatory activity; butanol; cell viability; cytotoxicity; ethanol; ethyl acetate; glutathione transferase; interleukin-6; lipopolysaccharides; medicinal plants; meningitis; methylene chloride; mitogen-activated protein kinase; nitric oxide; nitrites; petroleum; phosphorylation; pneumonia; prostaglandins; protein synthesis; quantitative polymerase chain reaction; quinones; traditional medicine; triterpenoids
Abstract:: ... Anchusa italica Retz. (Boraginaceae) is an important medicinal plant for the treatment of meningitis and pneumonia in traditional Uygur medicines.To clarify the anti-inflammatory activity of A. italica, to reveal its molecular mechanisms, and to discover the anti-inflammatory active ingredients.Dried and crushed aerial parts of A. italica were extracted with 75% ethanol to yield crude extract (AIC ...
DOI:: 10.1016/j.jep.2021.114899
: https://doi.org/10.1016/j.jep.2021.114899

94. Anti-inflammatory and anti-apoptotic effects of Shaoyao decoction on X-ray radiation-induced enteritis of C57BL/6 mice

Author:: Zhuohong Li; Ying Gao; Lei Du; Ye Yuan; Wenbo Huang; Xi Fu; Yongliang Huang; Xufan Zhang; Fengming You; Shijie Li
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115158
ISSN:: 0378-8741
Subject:: Western blotting; X-radiation; apoptosis; blood serum; caspase-3; collagen; colon; dexamethasone; enteritis; epithelium; fibrosis; fluorescence; fluorescent antibody technique; heat; interleukin-6; irradiation; males; mitochondria; models; peroxidation; pro-apoptotic proteins; protein content; traditional medicine
Abstract:: ... As a typical heat-clearing prescription, Shaoyao decoction (SYD) has a robust function of clearing viscera heat for the treatment of several intestinal discomfort symptoms. Clinical evidence indicated that it had the potential to cure radiation enteritis. However, its underlying mechanisms remain unclear. The present study was designed to probe the protective effects and the involved mechanisms of ...
DOI:: 10.1016/j.jep.2022.115158
: https://doi.org/10.1016/j.jep.2022.115158

95. Anti-inflammatory effect of Kaba Sura Kudineer (AYUSH approved COVID-19 drug)-A Siddha poly-herbal formulation against lipopolysaccharide induced inflammatory response in RAW-264.7 macrophages cells

Author:: Svenia P. Jose; Ratheesh M; Sheethal S; Sony Rajan; Sangeeth Saji; Vimal Narayanan; Sandya S
Source:: Journal of ethnopharmacology 2022 v.283 pp. 114738
ISSN:: 0378-8741
Subject:: COVID-19 infection; Western blotting; anti-inflammatory activity; dengue; drugs; enzyme-linked immunosorbent assay; inflammation; influenza; interleukin-6; lipopolysaccharides; macrophages; mice; nitric oxide; protein synthesis; secretion; signal transduction; therapeutics; traditional medicine; tuberculosis
Abstract:: ... Medicinal importance and potential activity of Siddha herbal formulations have proved over several centuries against a wide range of causative agents as Influenza, Dengue, Chikungunya, and Tuberculosis. The traditional medicine system of Siddha is a valuable therapeutic approach for treating viral respiratory infections like Coronavirus disease 2019 (COVID-19) and can be effectively employed to ta ...
DOI:: 10.1016/j.jep.2021.114738
: https://doi.org/10.1016/j.jep.2021.114738

96. Anti-inflammatory effects of Eclipta prostrata Linné on house dust mite-induced atopic dermatitis in vivo and in vitro

Author:: Yun-Mi Kang; Hye-Min Kim; Hwan Lee; Dong-Sung Lee; Hyo-Jin An
Source:: Journal of ethnopharmacology 2022 v.292 pp. 115233
ISSN:: 0378-8741
Subject:: CD4-positive T-lymphocytes; Eclipta prostrata; Western blotting; anti-inflammatory activity; atopic dermatitis; dermis; diabetes; dust; dust mites; enzyme-linked immunosorbent assay; histology; immune response; inflammation; jaundice; keratinocytes; medicinal plants; mitogen-activated protein kinase; obesity; people; phosphorylation; polymerase chain reaction; signal transduction; therapeutics; traditional medicine; transactivators
Abstract:: ... Atopic dermatitis (AD) is a kind of inflammation on the skin following with swollen, itchy, dryness and cracked skin. Though the exact cause of AD is unknown, there are evidence that people with AD have a compromised skin barrier along with inflammation. Eclipta prostrata Linné is a traditional herbal medicinal plant, has been used for the diabetes, obesity, jaundice, and inflammation. We supposed ...
DOI:: 10.1016/j.jep.2022.115233
: https://doi.org/10.1016/j.jep.2022.115233

97. Anti-inflammatory effects of aucubin in cellular and animal models of rheumatoid arthritis

Author:: Yan ZHANG; Li-Dong TANG; Jian-Ying WANG; Hao WANG; Xiao-Yun CHEN; Lei ZHANG; Ying YUAN
Source:: Chinese journal of natural medicines 2022 v.20 no.6 pp. 458-472
ISSN:: 1875-5364
Subject:: Western blotting; animal models; anti-inflammatory activity; apoptosis; aucubin; bone metabolism; cell differentiation; cell movement; fluorescent antibody technique; gene expression; histology; humans; inflammation; luciferase; micro-computed tomography; osteoclasts; pharmacodynamics; protein synthesis; reporter genes; rheumatoid arthritis
Abstract:: ... Rheumatoid arthritis (RA) is a chronic inflammatory autoimmune disease. It is known that aucubin (AU) exerts anti-inflammatory activity, but its effects and mechanisms in RA are unclear. This study investigated the anti-inflammatory effects and mechanisms of AU in vivo and in vitro. Human fibroblast-like synoviocyte cells from patients with RA (HFLS-RA), RAW264.7 cells, and MC3T3-E1 cells were use ...
DOI:: 10.1016/S1875-5364(22)60182-1
: https://doi.org/10.1016/S1875-5364(22)60182-1

98. Anti-inflammatory effects of flavonoids and phenylethanoid glycosides from Hosta plantaginea flowers in LPS-stimulated RAW 264.7 macrophages through inhibition of the NF-κB signaling pathway

Author:: Li Yang; Junwei He
Source:: BMC complementary medicine and therapies 2022 v.22 no.1 pp. 55
ISSN:: 2662-7671
Subject:: Hosta plantaginea; Western blotting; alternative medicine; enzyme-linked immunosorbent assay; flavonoids; flowers; glycosides; interleukin-6; lipopolysaccharides; macrophages; medicine; nitric oxide; prostaglandins; protein content; protein synthesis; secretion; toxicity; transcription factor NF-kappa B; viability; China
Abstract:: ... BACKGROUND: The flower of Hosta plantaginea (Lam.) Aschers has traditionally been used in China as an important Mongolian medicine for the treatment of inflammatory diseases with limited scientific evidence. In previous studies, 16 flavonoids and 3 phenylethanoid glycosides (1–19) were isolated from the ethanolic extract of H. plantaginea flowers. Nevertheless, the anti-inflammatory effects of the ...
DOI:: 10.1186/s12906-022-03540-1
: https://doi.org/10.1186/s12906-022-03540-1

99. Anti-melanogenesis effect from Wampee fruit pectin via α-MSH/TRY pathway in A375 cells

Author:: Weiyu Fu; Xuehua Liao; Qian Zhang; Yuzhen Zhu; Si Mei; Qian Li; Xin Zhou; Xiaojun Li; Hui Luo; Hua Ye; Kefeng Wu
Source:: BMC complementary medicine and therapies 2022 v.22 no.1 pp. 174
ISSN:: 2662-7671
Subject:: Clausena lansium; Fourier transform infrared spectroscopy; Western blotting; alternative medicine; antioxidant activity; arabinose; enzymes; fruits; galactose; galacturonic acid; gel chromatography; glucose; glucuronic acid; humans; mannose; melanin; melanogenesis; melanoma; models; molecular weight; mushrooms; nuclear magnetic resonance spectroscopy; pectins; rhamnose; ribose; tyrosine; water solubility
Abstract:: ... BACKGROUND: Polysaccharides from wampee have been reported to process various biological activities, while the relationship between structure and bioactivities has been barely addressed. Pectin, an abundant water-soluble polysaccharide in wampee, showed significant antioxidant activity, which was associated with the anti-melanogenic activity. Therefore, this study investigated the physicochemical ...
DOI:: 10.1186/s12906-022-03646-6
: https://doi.org/10.1186/s12906-022-03646-6

100. Anti-neuroinflammatory activity of 6,7-dihydroxy-2,4-dimethoxy phenanthrene isolated from Dioscorea batatas Decne partly through suppressing the p38 MAPK/NF-κB pathway in BV2 microglial cells

Author:: Ji Sun Lim; Jisun Oh; Hyun Seok Yun; Jeong Soon Lee; Dongyup Hahn; Jong-Sang Kim
Source:: Journal of ethnopharmacology 2022 v.282 pp. 114633
ISSN:: 0378-8741
Subject:: Dioscorea polystachya; Japan; Western blotting; cell viability; coculture; cytotoxicity; enzyme-linked immunosorbent assay; heme oxygenase (biliverdin-producing); inducible nitric oxide synthase; interleukin-6; lipopolysaccharides; mice; mitogen-activated protein kinase; necrosis; neoplasms; neurodegenerative diseases; neuroglia; neurons; nitric oxide; phenanthrenes; phosphorylation; prostaglandin synthase; rhizomes; therapeutics; traditional medicine; transcription (genetics); yams; China; Korean Peninsula; Taiwan
Abstract:: ... The rhizome of Dioscorea batatas Decne (called Chinses yam) widely distributed in East Asian countries including China, Japan, Korea and Taiwan has long been used in oriental folk medicine owing to its tonic, antitussive, expectorant and anti-ulcerative effects. It has been reported to have anti-inflammatory, antioxidative, cholesterol-lowering, anticholinesterase, growth hormone-releasing, antifu ...
DOI:: 10.1016/j.jep.2021.114633
: https://doi.org/10.1016/j.jep.2021.114633

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1. (−)-Epicatechin modulates the expression of myomiRs implicated in exercise response in mouse skeletal muscle

2. 23-O-acetylshengmanol-3-O-α-L-arabinoside alleviates lipopolysaccharide-induced acute lung injury through inhibiting IκB/NF-κB and MAPK/AP-1 signaling pathways

3. Ammonia-induced oxidative stress triggered proinflammatory response and apoptosis in pig lungs

4. Anti-inflammatory and osteoprotective effects of Shi-Wei-Ru-Xiang pills on collagen-induced arthritis in rats via inhibiting MAPK and STAT3 pathways

5. Atractylodes lancea and Magnolia officinalis combination protects against high fructose-impaired insulin signaling in glomerular podocytes through upregulating Sirt1 to inhibit p53-driven miR-221

6. Calcium pyruvate attenuates fat deposition by augmenting fatty acid oxidation and inhibiting glucose oxidation in juvenile large yellow croaker (Larimichthys crocea) consuming a high-fat diet

7. Celastrus orbiculatus Thunb. extract inhibits EMT and metastasis of gastric cancer by regulating actin cytoskeleton remodeling

8. Core-shell SERS nanotags-based western blot

9. Effects of breviscapine on cerebral ischemia-reperfusion injury and intestinal flora imbalance by regulating the TLR4/MyD88/NF-κB signaling pathway in rats

10. Hericium caput-medusae (Bull.:Fr.) Pers. fermentation concentrate polysaccharides improves intestinal bacteria by activating chloride channels and mucus secretion

11. Interaction of Polycyclic Aromatic Hydrocarbon compounds in fish primary hepatocytes: From molecular mechanisms to genotoxic effects

12. Saffron essential oil ameliorates CUMS-induced depression-like behavior in mice via the MAPK-CREB1-BDNF signaling pathway

13. Uncovering the effect and mechanism of Panax notoginseng saponins on metabolic syndrome by network pharmacology strategy

14. Xianglian Pill attenuates ulcerative colitis through TLR4/MyD88/NF-κB signaling pathway

15. The crude extract from the flowers of Trollius chinensis Bunge exerts anti-influenza virus effects through modulation of the TLR3 signaling pathway

16. The regulatory roles of DDIT4 in TDCIPP-induced autophagy and apoptosis in PC12 cells

17. (-) - Epicatechin improves Tibialis anterior muscle repair in CD1 mice with BaCl2-induced damage

18. (±)-Equol interferes with the secretion of gonadotropin-releasing hormone and the expression of neuromodulators in murine neurons

19. (−)-Agelasidine A Induces Endoplasmic Reticulum Stress-Dependent Apoptosis in Human Hepatocellular Carcinoma

20. 13,13a-seco-protoberberines from the tubers of Corydalis yanhusuo and their anti-inflammatory activity

21. 17β-estradiol modulates the expression of hormonal receptors on THP-1 T. gondii-infected macrophages and monocytes in an AKT and ERK-dependent manner

22. 17β-estradiol reduces NF-κB expression induced by increased crosstalk between KLF5 and ERα in murine vascular smooth muscle cells

23. 18β-Glycyrrhetinic acid altered the intestinal permeability in the human Caco-2 monolayer cell model

24. 2-Methoxyestradiol TPGS Micelles Attenuate Cyclosporine A-Induced Nephrotoxicity in Rats through Inhibition of TGF-β1 and p-ERK1/2 Axis

25. 20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo

26. 3,4,5‐O‐tricaffeoylquinic acid alleviates ionizing radiation‐induced injury in vitro and in vivo through regulating ROS/JNK/p38 signaling

27. 3,4-Dihydroxyphenylacetic acid ameliorates gut barrier dysfunction via regulation of MAPK-MLCK pathway in type 2 diabetes mice

28. IL- 37 alleviates liver granuloma caused by Schistosoma japonicum infection by inducing alternative macrophage activation

29. 5-Methoxytryptophan pretreatment alleviates lipopolysaccharide-induced cardiac injury and dysfunction

30. 5‐Heptadecylresorcinol Protects against Atherosclerosis in Apolipoprotein E‐Deficient Mice by Modulating SIRT3 Signaling: The Possible Beneficial Effects of Whole Grain Consumption

31. 6-OH-BDE-47 inhibited proliferation of skin fibroblasts from pygmy killer whale by inducing cell cycle arrest

32. 6-methoxydihydroavicine, the alkaloid extracted from Macleaya cordata (Willd.) R. Br. (Papaveraceae), triggers RIPK1/Caspase-dependent cell death in pancreatic cancer cells through the disruption of oxaloacetic acid metabolism and accumulation of reactive oxygen species

33. 7,8-Dihydroxyflavone attenuates the virulence of Staphylococcus aureus by inhibiting alpha-hemolysin

34. ABCA8 inhibits breast cancer cell proliferation by regulating the AMP activated protein kinase/mammalian target of rapamycin signaling pathway

35. ACSL4 promotes colorectal cancer and is a potential therapeutic target of emodin

36. ADAMTS8 inhibited lung cancer progression through suppressing VEGFA

37. AICAR stimulates mitochondrial biogenesis and BCAA catabolic enzyme expression in C2C12 myotubes

38. ALDH6A1 weakens the progression of colon cancer via modulating the RAS/RAF/MEK/ERK pathway in cancer cell lines

39. ASPN Is a Potential Biomarker and Associated with Immune Infiltration in Endometriosis

40. ASPP2 reduction attenuates HBV induced chronic liver damage: A hybrid mouse model study

41. ATP6V1H deficiency impairs glucose tolerance by augmenting endoplasmic reticulum stress in high fat diet fed mice

42. ATX/LPA axis regulates FAK activation, cell proliferation, apoptosis, and motility in human pancreatic cancer cells

43. Abnormal Expression of microRNA-296-3p in Type 2 Diabetes Patients and its Role in Pancreatic β-Cells Function by Targeting Tensin Homolog Deleted on Chromosome Ten

44. Activation of PGC‐1α via isoliquiritigenin‐induced downregulation of miR‐138‐5p alleviates nonalcoholic fatty liver disease

45. Activation of mitochondrial-associated apoptosis signaling pathway and inhibition of PI3K/Akt/mTOR signaling pathway by voacamine suppress breast cancer progression

46. Active legumain promotes invasion and migration of neuroblastoma by regulating epithelial-mesenchymal transition

47. Acute lead acetate induces neurotoxicity through decreased synaptic plasticity-related protein expression and disordered dendritic formation in nerve cells

48. Adiponectin affects uterine steroidogenesis during early pregnancy and the oestrous cycle: An in vitro study

49. Aerobic exercise improves adipogenesis in diet-induced obese mice via the lncSRA/p38/JNK/PPARγ pathway

50. Aerobic exercise improves intestinal mucosal barrier dysfunction through TLR4/MyD88/NF-κB signaling pathway in diabetic rats

51. Aeromonas hydrophila Ssp1: A secretory serine protease that disrupts tight junction integrity and is essential for host infection

52. Aesculetin exhibited anti-inflammatory activities through inhibiting NF-кB and MAPKs pathway in vitro and in vivo

53. Agrimoniin sensitizes pancreatic cancer to apoptosis through ROS-mediated energy metabolism dysfunction

54. Agrobacterium tumefaciens–mediated genetic transformation and overexpression of the flavonoid 3′5′-hydroxylase gene increases the flavonoid content of the transgenic Aconitum carmichaelii Debx. plant

55. Airway epithelial dysfunction and mesenchymal transition in chronic obstructive pulmonary disease: Role of Oct-4

56. Albumin (ALB) and protein disulfide isomerase family A member 4 (PDIA4) are novel markers to predict sperm freezability of Erhualian boar

57. All-trans retinoic acid-mediated miR-30a up-regulation suppresses autophagy and sensitizes gastric cancer cells to cisplatin

58. Alleviating Effects of Black Soybean Peptide on Oxidative Stress Injury Induced by Lead in PC12 Cells via Keap1/Nrf2/TXNIP Signaling Pathway

59. Allicin attenuated hepatic ischemia/reperfusion injury in mice by regulating PPARγ-IRAK-M-TLR4 signal pathway

60. Aloe emodin 3-O-glucoside inhibits cell growth and migration and induces apoptosis of non-small-cell lung cancer cells via suppressing MEK/ERK and Akt signalling pathways

61. Alpha-linolenic acid inhibits hepatocellular carcinoma cell growth through Farnesoid X receptor/β-catenin signaling pathway

62. Alpinae Oxyphyllae Fructus alleviated LPS‐induced cognitive impairments via PI3K/AKT/NF‐κB signaling pathway

63. Alteration of LncRNA expression in mice placentae after frozen embryo transfer is associated with increased fetal weight

64. The Alterations and Significance of Intercellular Adhesion Molecule-1 in Mouse Brainstem During Herpes Simplex Virus Type 1–Induced Facial Palsy

65. Alterations in connexin 43 gene and protein expression in the chicken oviduct following tamoxifen treatment

66. Altered m6A RNA methylation contributes to hippocampal memory deficits in Huntington’s disease mice

67. Amelioration of lipid accumulations and metabolism disorders in differentiation and development of 3T3-L1 adipocytes through mulberry leaf water extract

68. Amelioration of oxidative stress by trans-Anethole via modulating phase I and phase II enzymes against hepatic damage induced by CCl4 in male Wistar rats

69. Ameliorative effect of Gastrodia elata Blume extracts on depression in zebrafish and cellular models through modulating reticulon 4 receptors and apoptosis

70. Ameliorative effect of the ethnomedicinal plant Blepharis maderaspatensis (L.) B.Heyne ex Roth on lipopolysaccharide-induced acute liver inflammation and oxidative stress in Wistar rat model