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1. Anthelmintic activity of Stevia multiaristata extract against Echinococcus granulosus sensu stricto

Author:
C. M. Albani; J. Borgo; J. Fabbri; P. Pensel; L. Fasciani; O. Elso; D. Papademetrio; D. Grasso; A. Paladini; M. F. Beer; N. E. Farias; N. Elissondo; G. Gambino; J. Zoppi; V. Sülsen; M. C. Elissondo
Source:
Parasitology 2022 v.149 no.4 pp. 519-528
ISSN:
1469-8161
Subject:
Echinococcus granulosus; Stevia; adverse effects; albendazole; echinococcosis; larvae; median effective concentration; parasites; parasitology; protoscoleces; viability; zoonoses
Abstract:
... Cystic echinococcosis is a zoonotic disease caused by the larval stage of the parasite Echinococcus granulosus sensu lato. The available anti-parasitic treatment is mostly limited to a continuous administration of albendazole. However, due to its numerous side-effects and efficacy of around 50%, there is a need to find new drugs to improve the treatment for this disease. In the current study, the ...
DOI:
10.1017/S0031182021002109

2. Anthelmintic activity of methanol extract of Dennettia tripetala G. Baker (Annonaceae) fruits against Haemonchus contortus in red Sokoto goats

Author:
Rachel A. Nwosu; Mohammed M. Suleiman; Hussaina J. Makun; Matthew P. Ameh; Manji A. Shetshak; Isaac O. Akefe
Source:
Tropical animal health and production 2022 v.54 no.1 pp. 2
ISSN:
0049-4747
Subject:
Dennettia tripetala; Haemonchus contortus; Red Sokoto; adults; albendazole; albino; animal health; blood proteins; body weight; death; fecal egg count; gastrointestinal system; methanol; mortality; parasitoses; sheep; toxicity
Abstract:
... Haemonchosis is a gastrointestinal parasitic disease of economic importance in ruminants especially sheep and goats. In view of the rising costs of conventional veterinary anthelmintics and the development of resistance by Haemonchus contortus, there is a need to develop alternative ethnoveterinary therapies for the treatment and management of Haemonchosis. This study investigated the anthelmintic ...
DOI:
10.1007/s11250-021-03005-6

3. Biodegradation of anthelmintics in soils: does prior exposure of soils to anthelmintics accelerate their dissipation?

Author:
Stahis Lagos; Chrysovalantou Moutzoureli; Ifigenia Spiropoulou; Aggeliki Alexandropoulou; Panagiotis A. Karas; Anastasios Saratsis; Smaragda Sotiraki; Dimitrios G. Karpouzas
Source:
Environmental science and pollution research 2022 v.29 no.41 pp. 62404-62422
ISSN:
0944-1344
Subject:
adsorption; albendazole; barns; biodegradation; eprinomectin; farms; feces; gastrointestinal nematodes; ivermectin; pollution; research; sheep; soil; soil fumigation; total organic carbon
Abstract:
... Anthelmintics (AHs) control animal infections with gastrointestinal nematodes. They reach soil through animal faeces deposited on soils or through manuring. Although soil constitutes a major AH sink, we know little about the mechanisms controlling their soil dissipation. We employed studies with fumigated and non-fumigated soils collected from 12 sheep farms with a variable record of albendazole ( ...
DOI:
10.1007/s11356-022-19964-8

4. Design, synthesis, and in vitro evaluation of thiosemicarbazone derivatives as anti-filarial agents

Author:
Ramkishore Matsa; Parameshwar Makam; R. Anilakumari; M. Sundharesan; Nisha Mathew; Tharanikkarasu Kannan
Source:
Experimental parasitology 2022 v.241 pp. 108363
ISSN:
0014-4894
Subject:
Setaria digitata; Wuchereria bancrofti; adults; albendazole; cattle; colorimetry; diethylcarbamazine; ivermectin; nematicides; parasites; parasitology; tetrazolium; viability
Abstract:
... Effective macrofilaricidal drugs are not commercially available, and in an endeavour to find out new macrofilaricidal agents, in this research work, thiosemicarbazone derivatives have been prepared and tested against adult Setaria digitata, a cattle filarial parasite, as a model nematode for the filarial parasite, Wuchereria bancrofti. Lipinski and Veber rules have been used to design these molecu ...
DOI:
10.1016/j.exppara.2022.108363

5. The Effect of Season and Meteorological Conditions on Parasite Infection in Farm-Maintained Mouflons (Ovis aries Musimon)

Author:
B. Pilarczyk; A. Tomza-Marciniak; R. Pilarczyk; N. Sadowska; J. Udała; J. Kuba
Source:
Journal of parasitology research 2022 v.2022 pp. -
ISSN:
2090-0031
Subject:
Capillaria; Nematodirus; Ovis aries; Trichostrongylidae; air temperature; albendazole; deworming; farms; gastrointestinal system; herds; humidity; microclimate; mouflon; parasites; parasitology; parasitoses; pastures; research; risk; species diversity; spring; summer; winter
Abstract:
... Due to their limited environment, farm animals are at greater risk of parasitic infection than free-living animals, which also have greater natural resistance to parasitic diseases. The aim of the present study was to determine the influence of season and meteorological conditions (temperature and humidity) on the species composition and dynamics of parasitic infections in farmed mouflons. The stu ...
DOI:
10.1155/2022/1165782

6. Elimination of Giardia duodenalis BIV in vivo using natural extracts in microbiome and dietary supplements

Author:
Caroline Rodrigues de Almeida; Renata Coltro Bezagio; Cristiane Maria Colli; Liara Izabela Lopes Romera; Ariana Ferrari; Mônica Lúcia Gomes
Source:
Parasitology international 2022 v.86 pp. 102484
ISSN:
1383-5769
Subject:
Camellia sinensis; Giardia lamblia; albendazole; black tea; feces; intestinal mucosa; metronidazole; microbiome; models; parasite load; parasites; parasitology; therapeutics; trophozoites
Abstract:
... In this study, a combination therapy of several natural products was evaluated in vivo in the Giardia duodenalis infection model. G. duodenalis infected mice were treated as follows: distilled water (infected control C+), BIOintestil® (BIO; natural products of Cymbopogon martinii and Zingiber officinale), MicrobiomeX® (MBX; extract of Citrus sinensis and Citrus paradisi), MBX + BIO, Camellia sinen ...
DOI:
10.1016/j.parint.2021.102484

7. Evaluation of the mechanism of action of albendazole on adult rat lungworm (Angiostrongyluscantonensis)

Author:
John Jacob; Md Afjalus Siraj; Argon Steel; Ghee Tan; Susan Jarvi
Source:
Experimental parasitology 2022 v.242 pp. 108355
ISSN:
0014-4894
Subject:
Parastrongylus cantonensis; adults; albendazole; antimitotic agents; axonal transport; blood-brain barrier; cell viability; colorimetry; death; dose response; lungworms; mechanism of action; metabolites; metaphase; microtubules; nematicidal properties; neurons; parasitology; polymerization; rats; sulfoxides; toxicity testing; tubulin
Abstract:
... Albendazole is considered the anthelmintic of choice for the management of rat lungworm disease (neuroangiostrongyliasis), due to its broad spectrum of nematocidal activity and its ability to cross the blood-brain barrier. Albendazole binds to β-tubulins, preventing their polymerization into microtubules, thereby corrupting the cascade of cell division at metaphase, which ultimately leads to the d ...
DOI:
10.1016/j.exppara.2022.108355

8. Farmers' perception on the control of gastrointestinal parasites in organic and conventional sheep production in Sweden

Author:
Peter Halvarsson; Katarina Gustafsson; Johan Höglund
Source:
Veterinary Parasitology: Regional Studies and Reports 2022 v.30 pp. 100713
ISSN:
2405-9390
Subject:
Capreolus capreolus; Haemonchus contortus; albendazole; cattle; deworming; equipment; fecal examination; gastrointestinal nematodes; gastrointestinal system; herd size; ivermectin; land use; quarantine; questionnaires; risk factors; risk perception; surveys; veterinary parasitology; Sweden
Abstract:
... A questionnaire was sent to sheep owners in Sweden to get information about anthelmintic drug use. The survey also investigated how respondents experienced problems with gastrointestinal nematode infections (GIN) focusing on Haemonchus contortus. The response rate was 31% and included both conventional and organic farms. The use of anthelmintics was low (45%), among which a majority (76%) drenched ...
DOI:
10.1016/j.vprsr.2022.100713

9. Heme oxygenase-1 modulates brain inflammation and apoptosis in mice with angiostrongyliasis

Author:
Ke-Min Chen; Kuang-Ping Lan; Shih-Chan Lai
Source:
Parasitology international 2022 v.87 pp. 102528
ISSN:
1383-5769
Subject:
B-lymphocytes; Parastrongylus cantonensis; Western blotting; albendazole; apoptosis; blood-brain barrier; brain; caspase-3; cerebrospinal fluid; cobalt; enzyme-linked immunosorbent assay; gelatin; gelatinase B; heme oxygenase (biliverdin-producing); interleukin-10; interleukin-5; leukemia; lungworms; meningoencephalitis; necrosis; parasitology; permeability; protoporphyrin; rats; therapeutics
Abstract:
... The rat nematode lungworm Angiostrongylus cantonensis undergoes obligatory intracerebral migration in its hosts and causes eosinophilic meningitis or meningoencephalitis. Heme oxygenase 1 (HO-1) has several cytoprotective properties such as anti-oxidative, anti-inflammatory, and anti-apoptotic effects. HO-1 in brain tissues was induced in A. cantonensis-infected group and showed positive modulatio ...
DOI:
10.1016/j.parint.2021.102528

10. Identification and characterization of sirtuin enzymes in cestodes and evaluation of sirtuin inhibitors as new cestocidal molecules

Author:
Hugo Rolando Vaca; Ana María Celentano; María Agustina Toscanini; Alexander-Thomas Hauser; Natalia Macchiaroli; María Luján Cuestas; Alejandro David Nusblat; Wolfgang Sippl; María Celina Elissondo; Manfred Jung; Federico Camicia; Mara Cecilia Rosenzvit
Source:
International journal for parasitology 2022 v.52 no.5 pp. 317-329
ISSN:
0020-7519
Subject:
Echinococcus; Mesocestoides corti; active sites; albendazole; cysticercosis; dose response; echinococcosis; parasitology; sirtuins; transcription (genetics)
Abstract:
... Anti-parasitic treatment of neglected tropical diseases caused by cestodes such as echinococcosis and cysticercosis relies on a small number of approved anthelmintic drugs. Furthermore, the treatment is usually prolonged and often partially effective and not well tolerated by some patients. Therefore, the identification of novel drug targets and their associated compounds is critical. In this stud ...
DOI:
10.1016/j.ijpara.2021.12.002

11. Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep

Author:
Raquel Diez; M. Jose Diez; Juan J. Garcia; Jose M. Rodríguez; Cristina Lopez; Nelida Fernandez; Matilde Sierra; Ana M. Sahagun
Source:
Animals 2022 v.12 no.4 pp. -
ISSN:
2076-2615
Subject:
absorption; albendazole; benzimidazole; bioavailability; high performance liquid chromatography; metabolites; oral administration; pharmacokinetics; sheep; sulfoxides
Abstract:
... The pharmacokinetic interaction between a benzimidazole (albendazole, ABZ) and a choleretic drug (menbutone, MEN) was evaluated in sheep. The plasma disposition of albendazole sulfoxide (ABZSO, active metabolite) and albendazole sulfone (ABZSO₂, inactive metabolite) was investigated following an oral administration of albendazole (ABZ) (5 mg/kg) alone or with menbutone (MEN) (intramuscular, 10 mg/ ...
DOI:
10.3390/ani12040463

12. In silico to In vivo development of a polyherbal against Haemonchus contortus

Author:
Anu Rahal; D.K. Sharma; Ashok Kumar; Nitika Sharma; Deen Dayal
Source:
Heliyon 2022 v.8 no.1 pp. e08789
ISSN:
2405-8440
Subject:
Butea monosperma; Catharanthus roseus; Haemonchus contortus; Vitex negundo; albendazole; antioxidants; betulinic acid; chloroform; colchicine; computer simulation; depolymerization; dose response; electrostatic interactions; ethyl acetate; glutamate dehydrogenase; hexane; hydrogen; hydrophobic bonding; hydrophobicity; immunomodulation; larvicides; ligands; methanol; parasites; pharmacokinetics; prediction; small ruminants; tubulin; ursolic acid; vinblastine; vincristine
Abstract:
... Haemonchus contortus is a major constraint in the development of small ruminant subsector due to significant production losses incurred by it. The present study explores the antiparasitic potential of three anthelmintic plants (Butea monosperma, Vitex negundo and Catharanthus roseus (L.) G.Don) against H. contortus taking albendazole as the standard. In silico molecular docking and pharmacokinetic ...
DOI:
10.1016/j.heliyon.2022.e08789

13. In vitro and in vivo anthelmintic effects of Sterospermum kunthianum (Cham-Holl) leaf extract against Ascaridia galli in experimentally infected broiler chickens

Author:
Kyari Stephen; Ologunja Joseph Ajanusi; Mohammed Musa Suleiman; Ochuko Orakpoghenor; Matthew Ogwiji
Source:
Journal of parasitic diseases 2022 v.46 no.1 pp. 152-158
ISSN:
0971-7196
Subject:
Ascaridia galli; acute toxicity; albendazole; death; eggs; ethyl acetate; hexane; histopathology; leaf extracts; methanol; necrosis; oral administration
Abstract:
... This study was to assess the anthelminthic potential of Sterospermum kunthianum leaf extract against Ascaridia galli in experimentally infected broiler chickens. The extract and fractions were evaluated for in vitro inhibition and in vivo anthelmintic effects. Acute toxicity studies of extract revealed no sign of toxicity or death in birds at oral dose range of 1000–5000 and was considered safe. T ...
DOI:
10.1007/s12639-021-01426-6

14. Intraperitoneal and intracranial experimental cysticercosis present different metabolic preferences after treatment with isolated or combined albendazole and nitazoxanide

Author:
Guaraciara de Andrade Picanço; Nayana Ferreira de Lima; Taynara Cristina Gomes; Daniella de Sousa Mendes Moreira Alves; Tatiane Luísa da Costa; Marina Clare Vinaud
Source:
Acta tropica 2022 v.226 pp. 106264
ISSN:
0001-706X
Subject:
Taenia crassiceps; albendazole; catabolism; central nervous system; chromatography; cysticerci; cysticercosis; fermentation; glycolysis; humans; mitochondria; models; parasites; protein metabolism; public health; spectroscopy; succinate dehydrogenase (quinone)
Abstract:
... Cysticercosis is a zoonotic public health issue especially severe when the parasite is in the central nervous system although it may be found all over the human organism. Taenia crassiceps cysticerci inoculated in mice is the experimental model used to study cysticercosis. The most used cysticercosis treatment is with albendazole (ABZ). Nitazoxanide (NTZ) has been experimentally tested against thi ...
DOI:
10.1016/j.actatropica.2021.106264

15. Investigation of the effect of curcumin on oxidative stress, local inflammatory response, COX-2 expression, and microvessel density in Trichinella spiralis induced enteritis, myositis and myocarditis in mice

Author:
A. M. R. Hamed; I. R. Abdel-Shafi; M. D. A. Elsayed; A. M. Mahfoz; S. E. Tawfeek; M. S. A. Abdeltawab
Source:
Helminthologia 2022 v.59 no.1 pp. 18-36
ISSN:
1336-9083
Subject:
Trichinella spiralis; adjuvants; albendazole; anti-inflammatory activity; antioxidants; blood serum; curcumin; enteritis; histopathology; immunohistochemistry; inflammation; malondialdehyde; microvessels; myocarditis; myocardium; myositis; oxidative stress; parasite load; prostaglandin synthase; skeletal muscle; small intestine; therapeutics; trichinosis
Abstract:
... Curcumin exerts anti-oxidant and anti-inflammatory properties that have proven to be of value in the management of several parasitic infections. Investigation of the value of curcumin in the management of trichinosis either alone or as an adjuvant to albendazole. Animals received either curcumin 150 mg/kg, curcumin 300 mg/kg, albendazole 50 mg/ kg or combined curcumin 150mg/kg and albendazole 50 m ...
DOI:
10.2478/helm-2022-0002

16. Metformin improves the therapeutic efficacy of low-dose albendazole against experimental alveolar echinococcosis

Author:
Julia A. Loos; Magalí Coccimiglio; María Celeste Nicolao; Christian Rodriguez Rodrigues; Andrea C. Cumino
Source:
Parasitology 2022 v.149 no.1 pp. 138-144
ISSN:
1469-8161
Subject:
Echinococcus multilocularis; albendazole; disease severity; drug therapy; echinococcosis; glucose; inoculum; metacestodes; metformin; models; parasites; parasitology; toxicity
Abstract:
... Alveolar echinococcosis (AE) is a severe disease caused by Echinococcus multilocularis. Its chemotherapeutic treatment is based on benzimidazoles, which are rarely curative and cause several adverse effects. Therefore, it is necessary to develop alternative and safer chemotherapeutic strategies against AE. It has previously been shown that metformin (Met) exhibits considerable in vivo activity on ...
DOI:
10.1017/S0031182021001633

17. Multi-residue methodology for quantification of antiparasitics in hen eggs by LC-MS/MS: development, validation and application to 348 samples from Brazil

Author:
Caroline A. Tomaszewski; Fabiano Barreto; Lucas S. Barnet; Louise Jank; Tania Mara Pizzolato
Source:
Food additives & contaminants 2022 v.39 no.8 pp. 1412-1423
ISSN:
1944-0057
Subject:
acetonitrile; albendazole; eggs; fenbendazole; fipronil; ivermectin; maximum residue limits; mebendazole; metabolites; oxibendazole; sodium chloride; solvents; sulfoxides; Brazil
Abstract:
... Analytical methodology for quantification of 15 antiparasitic drugs and their respective metabolites in laying hen eggs was optimized and validated. The method uses acetonitrile as solvent extraction, sodium chloride for salting-out, low-temperature purification and analysis by LC-MS/MS. A total of 348 egg samples were collected in 11 states of Brazil and 50% of the total samples presented antipar ...
DOI:
10.1080/19440049.2022.2093984

18. Pharmacological characterization of geraniol in sheep and its potential use in the control of gastrointestinal nematodes

Author:
María Victoria Miró; Livio Martins Costa-Júnior; Luis Ignacio Alvarez; Carlos Lanusse; Guillermo Virkel; Adrián Lifschitz
Source:
Veterinary and Animal Science 2022 v.18 pp. 100269
ISSN:
2451-943X
Subject:
Haemonchus contortus; albendazole; animal science; fecal egg count; gastrointestinal nematodes; gastrointestinal system; geraniol; liver microsomes; pharmacokinetics; phytochemicals; sheep; sulfoxides
Abstract:
... Geraniol (GNL) was effective against gastrointestinal nematodes in vitro; nevertheless, the anthelmintic effect of phytochemicals combined with synthetic drugs has been little explored in vivo. This article characterized in vitro / in vivo the pharmacological features of GNL in sheep as well as its pharmacokinetic interaction with albendazole (ABZ). Additionally, the in vivo efficacy of GNL agains ...
DOI:
10.1016/j.vas.2022.100269

19. Phenotypic changes of Trichinella spiralis treated by Commiphora molmol,Lepidium sativum, and Albendazole: in vitro study

Author:
G. L. Abuelenain; Z. H. Fahmy; A. M. Elshennawy; E. H. A. Selim; M. Elhakeem; K. M. A. Hassanein; S. M. Awad
Source:
Helminthologia 2022 v.59 no.1 pp. 37-45
ISSN:
1336-9083
Subject:
Commiphora myrrha; Lepidium sativum; Trichinella spiralis; absorption; albendazole; experimental design; herbal medicines; muscles; myrrh resin; parasites; phenotype; survival rate; therapeutics; trichinosis
Abstract:
... Trichinellosis is a nematode-causing disease distinguished by its continuous transmission in the carnivores and omnivores. Despite effective eradication of the enteral forms, conventional drugs fail to eliminate the migrating and muscle ones. Over the past years, researchers intensified the work on herbal medicines as alternatives or aids to albendazole, the reference drug. This research hypothesi ...
DOI:
10.2478/helm-2022-0005

20. Phenotypic characterization and multiple resistance analysis in an experimentally selected albendazole-resistant hookworm isolate

Author:
Celi da Silva Medeiros; Lara Ribeiro de Almeida; Élida Mara Leite Rabelo; Luis Fernando Viana Furtado
Source:
Experimental parasitology 2022 pp. 108393
ISSN:
0014-4894
Subject:
Ancylostoma ceylanicum; adults; albendazole; blood serum; cross resistance; eggs; females; genotype; hematocrit; hemoglobin; hookworms; host-parasite relationships; ivermectin; males; mebendazole; morphometry; parasitology; pathogenicity; phenotype
Abstract:
... For some nematodes, alterations that leads to a resistance genotype may be accompanied by other modifications, causing changes in the biology of the parasite, although the exact mechanisms of this relationship are still not very clear. These alterations can have deleterious effects on their survival or even potentiate their pathogenicity. In this study a phenotypic characterization was carried out ...
DOI:
10.1016/j.exppara.2022.108393

21. Potential therapeutic effect of platelet-rich plasma and albendazole on the muscular phase of experimental Trichinella spiralis infection

Author:
Fatma M.A. Eissa; Ahmed H.A. Eassa; Rabab S. Zalat; Mohamed S. Negm; Marwa A. Elmallawany
Source:
Food and Waterborne Parasitology 2022 v.28 pp. e00180
ISSN:
2405-6766
Subject:
Trichinella spiralis; albendazole; drug therapy; fibrosis; histopathology; inflammation; muscles; parasitology; trichinosis
Abstract:
... Trichinellosis is a food-borne parasitic infection causing muscle damage. This study aimed to detect the potential therapeutic effect of platelet-rich plasma (PRP) alone or in combination with albendazole (ALB) on the muscular phase of experimental Trichinella infection in rats. The study was conducted on 70 rats divided into four main groups: healthy non-infected non-treated rats, non-infected ra ...
DOI:
10.1016/j.fawpar.2022.e00180

22. Regulation of apoptosis and autophagy by albendazole in human colon adenocarcinoma cells

Author:
Young Yun Jung; Seung Ho Baek; In Jin Ha; Kwang Seok Ahn
Source:
Biochimie 2022 v.198 pp. 155-166
ISSN:
0300-9084
Subject:
acridine orange; adenocarcinoma; albendazole; antioxidants; apoptosis; autophagy; carcinogenesis; cell cycle; colon; colorectal neoplasms; cysteine; cytotoxicity; humans; immunocytochemistry; neoplasm cells
Abstract:
... Albendazole (ABZ) was initially introduced as an anthelmintic, however, many studies have reported with its anticancer effects. We investigated the anti-tumor effects of ABZ in vitro in human colon adenocarcinoma HCT-15, HCT-116, HT-29, and SW480 cell lines in this study. The cytotoxicity of ABZ was analyzed in colon adenocarcinoma cell lines and normal CCD18Co cells. We found that ABZ induced the ...
DOI:
10.1016/j.biochi.2022.04.014

23. Signs of multiple anthelmintic resistance in sheep gastrointestinal nematodes in Sweden

Author:
Johan Höglund; Paulius Baltrušis; Nizar Enweji; Katarina Gustafsson
Source:
Veterinary Parasitology: Regional Studies and Reports 2022 pp. 100789
ISSN:
2405-9390
Subject:
DNA; Haemonchus; albendazole; droplets; farms; fecal egg count; fenbendazole; gastrointestinal nematodes; ivermectin; levamisole; moxidectin; risk; sheep; veterinary parasitology; Sweden
Abstract:
... Gastrointestinal nematodes in small ruminants are clinically and economically important parasites that often are controlled with anthelmintics. In this study, we compiled information on the anthelmintic efficacy collected on sheep farms according to routines established by Farm & Animal Health in Sweden. The efficacies of benzimidazoles (i.e. albendazole or fenbendazole, n = 30), ivermectin (n = 4 ...
DOI:
10.1016/j.vprsr.2022.100789

24. Therapeutic efficacy and bioaccumulation of albendazole in the treatment of tambaqui (Colossoma macropomum) parasitized by acanthocephalan (Neoechinorhynchus buttnerae)

Author:
Rafaelle Pereira Cordeiro; Patrícia Aparecida de Campos Braga; Claudio Martin Jonsson; Franmir Rodrigues Brandão; Edsandra Campos Chagas; Felix Guillermo Reyes Reyes
Source:
Aquaculture research 2022 v.53 no.4 pp. 1446-1455
ISSN:
1355-557X
Subject:
Colossoma macropomum; Neoechinorhynchus; albendazole; aquaculture; bioaccumulation; ethyl cellulose; fish; fish feeds; liquid chromatography; medicated feeds; metabolites; muscles; research; risk; tandem mass spectrometry; therapeutics
Abstract:
... The therapeutic efficacy of different doses of albendazole (ABZ) in the treatment of infection by acanthocephalan (Neoechinorhynchus buttnerae) in tambaqui (Colossoma macropomum) was evaluated. The bioaccumulation of ABZ and its main metabolites in the target tissue (muscle plus skin in natural proportions) was also evaluated. The fish received a daily dose of 10, 20 or 30 mg ABZ kg⁻¹ bw via medic ...
DOI:
10.1111/are.15677

25. Therapy and Prevention for Human Toxocariasis

Author:
Jean-François Magnaval; Emilie Bouhsira; Judith Fillaux
Source:
Microorganisms 2022 v.10 no.2 pp. -
ISSN:
2076-2607
Subject:
albendazole; epidemiology; humans; laboratory diagnosis; pathophysiology; poverty; therapeutics; toxocariasis; veterinary medicine; zoonoses
Abstract:
... For the last four decades, knowledge about human toxocariasis with regard to its epidemiology, pathophysiology, clinical spectrum, and imaging or laboratory diagnosis has substantially progressed. Knowledge about specific therapy with anthelmintics has lagged behind. To date, only four drugs are registered for human use, and their efficacy has rarely been assessed in prospective controlled trials. ...
DOI:
10.3390/microorganisms10020241

26. Trichostrongyle infections in domestic ruminants from Egypt: A systematic review and meta-analysis

Author:
Ibrahim Abbas; Michael B. Hildreth
Source:
Veterinary Parasitology: Regional Studies and Reports 2022 v.34 pp. 100761
ISSN:
2405-9390
Subject:
Haemonchus contortus; albendazole; cattle; confidence interval; eggs; epidemiology; meta-analysis; parasites; sheep; systematic review; veterinary parasitology; winter; Egypt
Abstract:
... Trichostrongylid nematodes can cause serious loss in the livestock economy; nevertheless, infections with these ubiquitous nematodes in animals from developing countries are largely neglected. The present paper provides a systematic review and meta-analysis to evaluate the status of trichostrongyle infections in domestic ruminants from Egypt. Out of 626 collected publications, 118 were defined sui ...
DOI:
10.1016/j.vprsr.2022.100761

27. Ultrastructural tegumental changes of Trichinella spiralis adult and larval stages after in vitro exposure to Allium sativum

Author:
Noha Abou Hussien; Mona Faheem; Eman Sweed; Asmaa Ibrahim
Source:
Experimental parasitology 2022 v.239 pp. 108314
ISSN:
0014-4894
Subject:
Allium sativum; Trichinella spiralis; adults; albendazole; furrows; larvae; mortality; parasitology; therapeutics; trichinosis
Abstract:
... Albendazole (ALB) is the most used therapeutic drug for trichinellosis treatment, but it has many drawbacks. Hence, the search for alternative natural compounds is a goal for researchers. The present work aimed to test the in vitro anthelmintic effect of Tomex (Allium sativum) against adult and muscular larva of Trichinella spiralis (T. spiralis). We incubated adult forms and muscular larvae of T. ...
DOI:
10.1016/j.exppara.2022.108314

28. The effect of Spondias mombin L. against Strongyloides venezuelensis: An in vitro approach

Author:
Paula Berna da Silva Medeiros; Tiago Manuel Fernandes Mendes; Vera Lucia Garcia; Rosimeire Nunes De Oliveira; Leticia Bastos Duart; Silmara Marques Allegretti
Source:
Acta tropica 2022 v.234 pp. 106617
ISSN:
0001-706X
Subject:
Spondias mombin; Strongyloides stercoralis; Strongyloides venezuelensis; albendazole; fractionation; ivermectin; models; mortality; parasites; phenol; polyvinylpyrrolidone; strongyloidiasis; therapeutics; thin layer chromatography; tropical diseases
Abstract:
... Strongyloidiasis is a neglected tropical disease mainly caused by the nematode parasite Strongyloides stercoralis. Current treatment consists in the administration of ivermectin or, alternatively, albendazole (or analogues). Concerns regarding these drugs’ irregular cure rates and side effects, raise a need for therapeutic alternatives. In this study, we tested the in vitro effect of Spondias momb ...
DOI:
10.1016/j.actatropica.2022.106617

29. The potentials of Calotropis procera against filarial elephantiasis: an in-silico approach

Author:
Aswin Mohan; Shanitha Shaji; Sunitha Padmanabhan; Shahanas Naisam; Nidhin Sreekumar
Source:
Journal of parasitic diseases 2022 v.46 no.2 pp. 384-394
ISSN:
0971-7196
Subject:
Bancroftian filariasis; Brugia malayi; Calotropis procera; Lewis acids; albendazole; alopecia; computer simulation; computer software; diethylcarbamazine; glutathione transferase; hematophagous arthropods; ivermectin; medicinal plants; molecular dynamics; nausea
Abstract:
... Lymphatic filariasis is one of the major diseases that belong to the category of neglected tropical illness. Filarial nematodes are the cause of the disease and are transmitted to humans via blood-feeding arthropod vectors. Drugs such as Albendazole, Ivermectin and diethylcarbamazine are administered either individually or in combination to overcome the progress of the lymphatic filariasis. These ...
DOI:
10.1007/s12639-021-01456-0

30. Albendazole Nanocrystal-Based Dissolving Microneedles with Improved Pharmacokinetic Performance for Enhanced Treatment of Cystic Echinococcosis

Author:
Andi Dian Permana; Alejandro J. Paredes; Fabiana Volpe Zanutto; Muh. Nur Amir; Ismail Ismail; Muh. Akbar Bahar; Sumarheni; Santiago Daniel Palma; Ryan F. Donnelly
Source:
ACS applied materials & interfaces 2021 v.13 no.32 pp. 38745-38760
ISSN:
1944-8252
Subject:
Echinococcus; albendazole; bioavailability; crystal structure; dermis; echinococcosis; liver; nanocrystals; oral administration; pharmacokinetics; solubility; stabilizers; strength (mechanics); swine; zoonoses
Abstract:
... Cystic echinococcosis (CE) is a zoonosis caused by Echinococcus spp., affecting both humans and animals’ lives. Current treatment of CE by oral administration of albendazole (ABZ) is hampered by several limitations. The poor aqueous solubility and the rapid metabolism of ABZ in the liver are the main issues, leading to lack of efficacy of the treatment. In the present study, we developed a nanocry ...
DOI:
10.1021/acsami.1c11179

31. Albendazole and praziquantel for the control of Neoechinorhynchus buttnerae in tambaqui (Colossoma macropomum)

Author:
Caio Francisco Santana Farias; Franmir Rodrigues Brandão; Fernanda de Alexandre Sebastião; Damy Caroline de Melo Souza; Patrícia Castro Monteiro; Cláudia Majolo; Edsandra Campos Chagas
Source:
Aquaculture international 2021 v.29 no.4 pp. 1495-1505
ISSN:
0967-6120
Subject:
Colossoma macropomum; Neoechinorhynchus; albendazole; commercialization; diet; experimental design; fish; indigenous species; palatability; praziquantel; toxicity; Brazil
Abstract:
... The increase in the production and commercialization of aquatic organisms in Brazil is partly due to the growth of native species such as tambaqui. The intensification of fish farming systems has led to an increased occurrence of parasitic diseases, and this has become a serious issue, especially in fish farms in northern Brazil. The present study evaluated the use of albendazole and praziquantel ...
DOI:
10.1007/s10499-021-00687-5

32. Alterations in Taenia crassiceps cysticerci cytoskeleton induced by nitazoxanide and flubendazole

Author:
Nayana Ferreira de Lima; Guaraciara de Andrade Picanço; Diana Gabriela Ríos Valencia; Edgar Oliver López Villegas; María Del Rosário Espinoza Mellado; Javier R. Ambrosio; Marina Clare Vinaud
Source:
Acta tropica 2021 v.221 pp. 106027
ISSN:
0001-706X
Subject:
Taenia crassiceps; Taenia solium; Western blotting; actin; albendazole; central nervous system; cysticerci; cysticercosis; cytoskeleton; electrophoresis; eyes; flubendazole; larvae; models; parasites; praziquantel; transmission electron microscopy; tubulin
Abstract:
... Cysticercosis is the presence of Taenia solium larval stage in tissues such as central nervous system, skin, muscles and eye globe. The current treatment is based on albendazole and praziquantel which already present resistance reports. Therefore, the search for alternative treatments is paramount. The aim of this study was to determine the effect of flubendazole and nitazoxanide on cytoskeleton p ...
DOI:
10.1016/j.actatropica.2021.106027

33. Alveolar Echinococcosis of the Parotid Gland—An Ultra Rare Location Reported from Western Europe

Author:
Tim Koppen; Thomas F. E. Barth; Klaus W. Eichhorn; Jennis Gabrielpillai; Ralph Kader; Friedrich Bootz; Thorsten Send
Source:
Pathogens 2021 v.10 no.4 pp. -
ISSN:
2076-0817
Subject:
Echinococcus multilocularis; adjuvants; albendazole; echinococcosis; histology; larvae; liver; males; nerve tissue; parotid gland; patients; resection; zoonoses; Central Asia; Central European region; China; Europe; Western European region
Abstract:
... (1) Background: Alveolar echinococcosis (AE) is restricted to the northern hemisphere with high endemic regions in Central Europe, North and Central Asia as well as Western China. The larval stage of Echinococcus multilocularis (E. multilocularis) causes AE with tumor-like growth. Humans are accidental hosts. This report is on the first case of AE becoming clinically manifested in the parotic glan ...
DOI:
10.3390/pathogens10040426

34. Anthelmintic Drug Resistance of Gastrointestinal Nematodes of Naturally Infected Goats in Haramaya, Ethiopia

Author:
Anteneh Wondimu; Yehualashet Bayu
Source:
Journal of parasitology research 2022 v.2022 pp. -
ISSN:
2090-0031
Subject:
Haemonchus; Teladorsagia; Trichostrongylus; albendazole; fecal egg count; gastrointestinal nematodes; gastrointestinal system; goats; ivermectin; larvae; multiple drug resistance; parasitology; research; tetramisole; Ethiopia
Abstract:
... Gastrointestinal parasites and their anthelmintic resistance are major constraints to goat production in Ethiopia. Experimental investigation by faecal egg count reduction test (FECRT) and larval cultures were used to assess the occurrence of anthelmintic resistance in naturally infected goats with gastrointestinal nematodes (GIN) in Haramaya, Ethiopia. One hundred goats with a minimum of 150 eggs ...
DOI:
10.1155/2022/4025902

35. Anthelmintic resistance of gastrointestinal nematodes in sheep grazing in irrigated and dry areas in the semiarid region of northeastern Brazil

Author:
Lauricia S. Nascimento; Anna M. C. F. Evaristo; Glauber M. B. Oliveira; Matheus S. Ferreira; Déborah L. R. Silva; Sergio S. Azevedo; Sandra M. Yamamoto; Márcia M. Araújo; Mauricio C. Horta
Source:
Tropical animal health and production 2021 v.53 no.2 pp. 267
ISSN:
0049-4747
Subject:
Haemonchus contortus; adults; albendazole; closantel; deworming; fecal egg count; feces; flocks; gastrointestinal nematodes; irrigated farming; irrigation; ivermectin; levamisole; moxidectin; semiarid zones; sheep; Brazil
Abstract:
... This study aimed to determine the AR of gastrointestinal nematodes (GIN) to commercial drugs in sheep flocks naturally infected, grazing in irrigated (IA) and dry (DA) areas of the semiarid region in northeastern Brazil. Fecal egg count reduction tests (FECRT) were performed at 10 farms. From each flock, 36 adult sheep were selected and divided into five groups (G1 (0.08% ivermectin), G2 (10% albe ...
DOI:
10.1007/s11250-021-02647-w

36. Anti-echinococcal effect of verapamil involving the regulation of the calcium/calmodulin-dependent protein kinase II response in vitro and in a murine infection model

Author:
Hai-Jun Gao; Xu-Dong Sun; Yan-Ping Luo; Hua-Sheng Pang; Xing-Ming Ma; Ting Zhang; Tao Jing; Wei Hu; Yu-Juan Shen; Jian-Ping Cao
Source:
Parasites & vectors 2021 v.14 no.1 pp. 108
ISSN:
1756-3305
Subject:
Echinococcus granulosus; Echinococcus multilocularis; albendazole; alizarin; atomic absorption spectrometry; blood serum; calcium; calcium-calmodulin-dependent protein kinase; drug therapy; echinococcosis; gene expression; immunohistochemistry; liver; mice; models; parasites; protoscoleces; quantitative polymerase chain reaction; ultrastructure; verapamil; zoonoses
Abstract:
... BACKGROUND: Echinococcosis, which is caused by the larvae of cestodes of the genus Echinococcus, is a parasitic zoonosis that poses a serious threat to the health of humans and animals globally. Albendazole is the drug of choice for the treatment of echinococcosis, but it is difficult to meet clinical goals with this chemotherapy due to its low cure rate and associated side effects after its long- ...
DOI:
10.1186/s13071-021-04618-4

37. Anti-pinworm activity of novel coumarin-based trisubstituted methanes in Syphacia obvelata-infected mice

Author:
Errini Decruse Dhar; Arun K. Yadav; Grace Basumatary; Ghanashyam Bez
Source:
Parasitology international 2021 v.85 pp. 102425
ISSN:
1383-5769
Subject:
Syphacia; acute toxicity; albendazole; body weight; parasitology; risk
Abstract:
... The control of pinworms mainly relies on use of anthelmintic drugs. At present, there exists only few medications against pinworms, and their repeated use pose a serious risk of resistance development. Therefore, new anti-pinworm drugs are required to overcome the risk of resistance. This study reports the anti-pinworm activity of three novel coumarin-based trisubstituted methanes (TRSMs), i.e., 6 ...
DOI:
10.1016/j.parint.2021.102425

38. Anti-trypanosomal and anthelminthic properties of ethanol and aqueous extracts of Tetrapleura tetraptera Taub

Author:
Ahmed Wahab Obeng; Yaw Duah Boakye; Theresa Appiah Agana; Georgina Isabella Djameh; Daniel Boamah; Francis Adu
Source:
Veterinary parasitology 2021 v.294 pp. 109449
ISSN:
0304-4017
Subject:
Pheretima; Tetrapleura tetraptera; adults; albendazole; antitrypanosomal properties; death; dose response; ethanol; flavonoids; fruits; gas chromatography-mass spectrometry; paralysis; parasites; public health; saponins; triterpenoids; trypanosomiasis; veterinary parasitology; Africa
Abstract:
... Trypanosomosis and helminthosis, considered as part of neglected tropical diseases, are parasitic infections of public health importance, especially in Africa. Medicinal plants have been used in most parts of Africa, to treat these parasitic infections. The study aims to determine the anti-trypanosomal and anthelminthic properties of Tetrapleura tetraptera (fruit and stembark). The aqueous extract ...
DOI:
10.1016/j.vetpar.2021.109449

39. Antinematodic effect of Enterococcus faecalis CECT7121 using Trichinella spiralis as a model of nematode infection in mice

Author:
Laureano Schofs; Mónica D. Sparo; María Guadalupe de Yaniz; Sabina Lissarrague; María Paula Domínguez; Luis I. Álvarez; Sergio F. Sánchez Bruni
Source:
Experimental parasitology 2022 v.241 pp. 108358
ISSN:
0014-4894
Subject:
Enterococcus faecalis; Trichinella spiralis; albendazole; antimicrobial peptides; human population; larvicides; models; muscle tissues; nematode infections; oral administration; parasitology; probiotics; protective effect; viability
Abstract:
... Nematode infections affect a significant percentage of the human population worldwide, especially in developing countries. There are a small number of drugs available to treat these infections, with variable outcomes. Therefore, the potential use of probiotics to help control parasitic infections has emerged as a suitable option. The main goal of this work was to assess the antinematodic effect of ...
DOI:
10.1016/j.exppara.2022.108358

40. An Artemisia cina n-hexane extract reduces the Haemonchus contortus and Teladorsagia circumcincta fecal egg count in naturally infected periparturient goats

Author:
Rosa Isabel Higuera-Piedrahita; Mariana Dolores-Hernández; Héctor Alejandro de la-Cruz-Cruz; Héctor Mario Andrade-Montemayor; Alejandro Zamilpa; Raquel López-Arellano; Roberto González-Garduño; Jorge Alfredo Cuéllar-Ordaz; Pedro Mendoza-de-Gives; Ma. Eugenia López-Arellano
Source:
Tropical animal health and production 2022 v.54 no.2 pp. 95
ISSN:
0049-4747
Subject:
Artemisia; Haemonchus contortus; Teladorsagia circumcincta; adults; albendazole; analysis of variance; animal health; body condition; color; deworming; eggs; fecal egg count; flocks; goats; hexane; mass spectrometry; mucosa; oral administration; placebos
Abstract:
... The objective of this study was to evaluate an n-hexane extract of Artemisia cina (Acn-h) as a natural anthelmintic treatment for periparturient goats naturally infected with the nematodes Haemonchus contortus and Teladorsagia circumcincta. A total of 200 periparturient Alpine and Nubian goats were used. Deworming criteria were based on the following parameters: fecal egg account (epg), ocular muc ...
DOI:
10.1007/s11250-022-03103-z

41. Assessing the Efficacy of Albendazole against Fasciola hepatica in Naturally Infected Cattle by In Vivo and In Vitro Methods

Author:
Michal Babják; Alžbeta Königová; Ľudmila Burcáková; Michaela Komáromyová; Michaela Urda Dolinská; Marián Várady
Source:
Veterinary sciences 2021 v.8 no.11 pp. -
ISSN:
2306-7381
Subject:
Charolais; Fasciola hepatica; albendazole; autumn; body weight; diagnostic techniques; eggs; farms; fascioliasis; fecal egg count; ovicides
Abstract:
... This study was performed on a cattle farm with a long-term use of albendazole (ABZ) and a permanent history of fasciolosis for comparing in vivo and in vitro methods for the detection of anthelmintic resistance and drug efficacy. A selected group of 10 Charolais cows was treated in autumn 2020 with ABZ at a dose of 7.5 mg/kg body weight. Another group of 10 cows remained untreated as a control. Th ...
DOI:
10.3390/vetsci8110249

42. Bioaugmentation of animal feces as a mean to mitigate environmental contamination with anthelmintic benzimidazoles

Author:
S. Lagos; C. Perruchon; A. Tsikriki; E. Gourombinos; S. Vasileiadis; S. Sotiraki; D.G. Karpouzas
Source:
Journal of hazardous materials 2021 v.419 pp. 126439
ISSN:
0304-3894
Subject:
albendazole; benzimidazole; bioaugmentation; environmental exposure; excretion; feces; fenbendazole; flubendazole; fumigation; gastrointestinal nematodes; liquids; mebendazole; metabolism; microbial communities; pollution; sheep; thiabendazole
Abstract:
... Anthelmintics are used to control infestations of ruminants by gastrointestinal nematodes. The limited metabolism of anthelmintics in animals result in their excretion in feces. These could be piled up in the floor of livestock farms, constituting a point source of environmental contamination, or used as manures in agricultural soils where they persist or move to water bodies. Hence the removal of ...
DOI:
10.1016/j.jhazmat.2021.126439

43. Capsicum frutescens and Citrus limon: a new take on therapy against experimental trichinellosis

Author:
Marwa Ahmed Mohamed Salama; Nahed E. Mostafa; Naglaa Fathy Abd El-Aal; Eman M. Mostafa; Samar Kamel Hammad; Rasha Adel; Howayda Said Fouad Moawad
Source:
Journal of helminthology v.95 pp. e26
ISSN:
1475-2697
Subject:
Capsicum frutescens; Citrus limon; absorption; adults; albendazole; albino; blood serum; death; histopathology; human health; larvae; males; mice; necrosis; neoplasms; prednisolone; small intestine; therapeutics; transmission electron microscopy; trichinosis; zoonoses
Abstract:
... Trichinellosis is a zoonotic disease that endangers human health and can lead to death. Restricted absorption and poor results of conventional therapies demand new effective natural remedies to treat both enteral and parenteral trichinellosis. This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with ...
DOI:
10.1017/S0022149X21000171

44. Characterizing dynamic changes of plasma cell-free Echinococcus granulosus DNA before and after cystic echinococcosis treatment initiation

Author:
Yanping Zhao; Quzhen Gongsang; Jingkai Ji; Junhua Li; Fahai Qi; Jiandong Li; Gezhen Qiangba; Wangmu Danzeng; Fang Chen; Hongcheng Zhou; Huasang; Jiefang Yin; Na Pei; Jiandan Xie; Huimin Cai; Asan; Huasheng Pang; Jingzhong Li; Weijun Chen; Bin Li
Source:
Genomics 2021 v.113 no.2 pp. 576-582
ISSN:
0888-7543
Subject:
DNA; Echinococcus granulosus; albendazole; echinococcosis; genomics; ultrasonics
Abstract:
... Over one million people are living with cystic echinococcosis (CE) and alveolar echinococcosis (AE). For CE, long-term albendazole treatment is often needed, which requires regular follow-up. Follow-up is mainly through imaging which is insensitive to subtle changes and subjective to experience. We investigated the changes of Echinococcus granulosus (Eg) cell-free DNA (cfDNA) in plasma of CE patie ...
DOI:
10.1016/j.ygeno.2020.12.035

45. Chemical characterization and in vitro anthelmintic activity of Citrus bergamia Risso and Citrus X paradisii Macfad essential oil against Haemonchus contortus Kirby isolate

Author:
Vivien Patricia Garbin; Beatriz Munguía; Jenny Carolina Saldaña; Cícero Deschamps; Roger Raupp Cipriano; Marcelo Beltrão Molento
Source:
Acta tropica 2021 v.217 pp. 105869
ISSN:
0001-706X
Subject:
Citrus bergamia; Haemonchus contortus; abomasum; adults; albendazole; citrus peels; eggs; equipment; essential oils; food composition; hematophagous parasites; larvae; limonene; nematode control; secondary metabolites
Abstract:
... Haemonchus contortus, a blood-sucking parasite of small ruminants, produces very important economic losses in the productive sector. This abomasum parasite has become resistant to most commercial drugs worldwide, and alternatives to fight this problem are urgently needed. Essential oils (EO) are a complex mixture of volatile secondary metabolites, composed mainly by terpenoids and phenolic compoun ...
DOI:
10.1016/j.actatropica.2021.105869

46. Clinical tolerance and efficacy of anti-parasitic treatment with albendazole in patients with alveolar echinococcosis: long-term follow-up observation in 117 patients

Author:
Valerij D. Zavoikin; Olga P. Zelya; Nelli I. Tumolskaya
Source:
Parasitology research 2021 v.120 no.10 pp. 3603-3610
ISSN:
0932-0113
Subject:
albendazole; blood serum; echinococcosis; liver; neoplasms; parasitology; research; resection; transaminases
Abstract:
... Alveolar echinococcosis is the most severe worm disease primarily detected in the liver. This study aimed to determine the clinical tolerance and efficacy of albendazole in patients with alveolar echinococcosis, depending on the volume of previous surgical treatment or its absence and the duration of anti-parasitic therapy. We retrospectively (over the last 15 years) analyzed the data of 117 patie ...
DOI:
10.1007/s00436-021-07297-3

47. Combination of synthetic anthelmintics and monoterpenes: Assessment of efficacy, and ultrastructural and biophysical properties of Haemonchus contortus using atomic force microscopy

Author:
Carolina R. Silva; Adrian L. Lifschitz; Sara R.D. Macedo; Nagilla R.C.L. Campos; Malaquias Viana-Filho; Ana C.S. Alcântara; Josiel G. Araújo; Luciana M.R. Alencar; Livio M. Costa- Junior
Source:
Veterinary parasitology 2021 v.290 pp. 109345
ISSN:
0304-4017
Subject:
Fourier transform infrared spectroscopy; Haemonchus contortus; albendazole; atomic force microscopy; carvacrol; carvone; citral; eggs; larvae; levamisole; p-cymene; parasites; roughness; synergism; thymol; ultrastructure; veterinary parasitology
Abstract:
... The resistance of Haemonchus contortus to synthetic anthelmintics is of increasing concern; and different strategies are being evaluated to improve parasite control. The present study investigated the in vitro effects of combinations of synthetic compounds and monoterpenes. Additionally, the chemical association of the best combinations and their impact on the ultrastructural and biophysical prope ...
DOI:
10.1016/j.vetpar.2021.109345

48. Community-based trial assessing the impact of annual versus semiannual mass drug administration with ivermectin plus albendazole and praziquantel on helminth infections in northwestern Liberia

Author:
Obiora A. Eneanya; Lincoln Gankpala; Charles W. Goss; Aaron T. Momolu; Enoch S. Nyan; Emmanuel B. Gray; Kerstin Fischer; Kurt Curtis; Fatorma K. Bolay; Gary J. Weil; Peter U. Fischer
Source:
Acta tropica 2022 v.231 pp. 106437
ISSN:
0001-706X
Subject:
Bancroftian filariasis; Ebolavirus; Onchocerca volvulus; Schistosoma mansoni; Wuchereria bancrofti; albendazole; endemic diseases; hookworms; ivermectin; onchocerciasis; praziquantel; regression analysis; schistosomiasis; Liberia
Abstract:
... We assessed the impact of three annual vs five semiannual rounds of mass drug administration (MDA) with ivermectin plus albendazole followed by praziquantel for the control or elimination of lymphatic filariasis (LF), onchocerciasis, soil-transmitted helminth (STH) infections and schistosomiasis in Lofa County, Liberia. The study started in 2012 and was interrupted in 2014 during the Ebola virus o ...
DOI:
10.1016/j.actatropica.2022.106437

49. Computational screening of potential inhibitors targeting MurF of Brugia malayi Wolbachia through multi-scale molecular docking, molecular dynamics and MM-GBSA analysis

Author:
Saritha Poopandi; Rajamanikandan Sundaraj; Raji Rajmichael; Sindhu Thangaraj; Prabhu Dhamodharan; Jayashree Biswal; Veerapandiyan Malaisamy; Chitra Jeyaraj Pandian; Jeyakanthan Jeyaraman
Source:
Molecular and biochemical parasitology 2021 v.246 pp. 111427
ISSN:
0166-6851
Subject:
Bancroftian filariasis; Brugia malayi; Gibbs free energy; Wolbachia; Wuchereria bancrofti; absorption; albendazole; biosynthesis; density functional theory; diethylcarbamazine; endosymbionts; excretion; ivermectin; ligases; mechanics; molecular dynamics; nematicides; parasitology; peptidoglycans; pharmacokinetics; surface area; therapeutics; toxicity; zinc
Abstract:
... Lymphatic filariasis is a parasitic disease caused by the worms Wuchereria bancrofti, Brugia malayi and Brugia timori. Three anti-filarial drugs namely Diethylcarbamazine, Ivermectin and Albendazole and their combinations are used as the control strategies for filariasis. The disease has received much attention in drug discovery due to the unavailability of vaccines and the toxic pharmaceutical pr ...
DOI:
10.1016/j.molbiopara.2021.111427

50. Cysticidal effect of a pure naphthoquinone on Taenia crassiceps cysticerci

Author:
Yuli Aranda-López; Lluvia López-López; Karen Elizabeth Nava Castro; María Dolores Ponce-Regalado; Luis Enrique Becerril-Villanueva; Manuel Iván Girón-Pérez; Víctor Hugo Del Río-Araiza; Jorge Morales-Montor
Source:
Parasitology research 2021 v.120 no.11 pp. 3783-3794
ISSN:
0932-0113
Subject:
Taenia crassiceps; Taenia solium; albendazole; bioavailability; cysticerci; helminths; mice; models; naphthoquinones; neurocysticercosis; paralysis; parasitology; reproduction; research; therapeutics
Abstract:
... Cysticercosis is a disease caused by the metacestode of the parasite Taenia solium (T. solium). In humans, the most severe complication of the disease is neurocysticercosis. The drug of choice to treat this disease is albendazole; however, the bioavailability and efficacy of the drug are variable. Therefore, new molecules with therapeutic effects against this and other parasitic infections caused ...
DOI:
10.1007/s00436-021-07281-x