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1. Anthelmintic Drug Resistance of Gastrointestinal Nematodes of Naturally Infected Goats in Haramaya, Ethiopia

Author:
Anteneh Wondimu; Yehualashet Bayu
Source:
Journal of parasitology research 2022 v.2022 pp. -
ISSN:
2090-0031
Subject:
Haemonchus; Teladorsagia; Trichostrongylus; albendazole; fecal egg count; gastrointestinal nematodes; gastrointestinal system; goats; ivermectin; larvae; multiple drug resistance; parasitology; research; tetramisole; Ethiopia
Abstract:
... Gastrointestinal parasites and their anthelmintic resistance are major constraints to goat production in Ethiopia. Experimental investigation by faecal egg count reduction test (FECRT) and larval cultures were used to assess the occurrence of anthelmintic resistance in naturally infected goats with gastrointestinal nematodes (GIN) in Haramaya, Ethiopia. One hundred goats with a minimum of 150 eggs ...
DOI:
10.1155/2022/4025902

2. Anthelmintic activity of Stevia multiaristata extract against Echinococcus granulosus sensu stricto

Author:
C. M. Albani; J. Borgo; J. Fabbri; P. Pensel; L. Fasciani; O. Elso; D. Papademetrio; D. Grasso; A. Paladini; M. F. Beer; N. E. Farias; N. Elissondo; G. Gambino; J. Zoppi; V. Sülsen; M. C. Elissondo
Source:
Parasitology 2022 v.149 no.4 pp. 519-528
ISSN:
1469-8161
Subject:
Echinococcus granulosus; Stevia; adverse effects; albendazole; echinococcosis; larvae; median effective concentration; parasites; parasitology; protoscoleces; viability; zoonoses
Abstract:
... Cystic echinococcosis is a zoonotic disease caused by the larval stage of the parasite Echinococcus granulosus sensu lato. The available anti-parasitic treatment is mostly limited to a continuous administration of albendazole. However, due to its numerous side-effects and efficacy of around 50%, there is a need to find new drugs to improve the treatment for this disease. In the current study, the ...
DOI:
10.1017/S0031182021002109

3. Anthelmintic activity of methanol extract of Dennettia tripetala G. Baker (Annonaceae) fruits against Haemonchus contortus in red Sokoto goats

Author:
Rachel A. Nwosu; Mohammed M. Suleiman; Hussaina J. Makun; Matthew P. Ameh; Manji A. Shetshak; Isaac O. Akefe
Source:
Tropical animal health and production 2022 v.54 no.1 pp. 2
ISSN:
0049-4747
Subject:
Dennettia tripetala; Haemonchus contortus; Red Sokoto; adults; albendazole; albino; animal health; blood proteins; body weight; death; fecal egg count; gastrointestinal system; methanol; mortality; parasitoses; sheep; toxicity
Abstract:
... Haemonchosis is a gastrointestinal parasitic disease of economic importance in ruminants especially sheep and goats. In view of the rising costs of conventional veterinary anthelmintics and the development of resistance by Haemonchus contortus, there is a need to develop alternative ethnoveterinary therapies for the treatment and management of Haemonchosis. This study investigated the anthelmintic ...
DOI:
10.1007/s11250-021-03005-6

4. Antinematodic effect of Enterococcus faecalis CECT7121 using Trichinella spiralis as a model of nematode infection in mice

Author:
Laureano Schofs; Mónica D. Sparo; María Guadalupe de Yaniz; Sabina Lissarrague; María Paula Domínguez; Luis I. Álvarez; Sergio F. Sánchez Bruni
Source:
Experimental parasitology 2022 v.241 pp. 108358
ISSN:
0014-4894
Subject:
Enterococcus faecalis; Trichinella spiralis; albendazole; antimicrobial peptides; human population; larvicides; models; muscle tissues; nematode infections; oral administration; parasitology; probiotics; protective effect; viability
Abstract:
... Nematode infections affect a significant percentage of the human population worldwide, especially in developing countries. There are a small number of drugs available to treat these infections, with variable outcomes. Therefore, the potential use of probiotics to help control parasitic infections has emerged as a suitable option. The main goal of this work was to assess the antinematodic effect of ...
DOI:
10.1016/j.exppara.2022.108358

5. An Artemisia cina n-hexane extract reduces the Haemonchus contortus and Teladorsagia circumcincta fecal egg count in naturally infected periparturient goats

Author:
Rosa Isabel Higuera-Piedrahita; Mariana Dolores-Hernández; Héctor Alejandro de la-Cruz-Cruz; Héctor Mario Andrade-Montemayor; Alejandro Zamilpa; Raquel López-Arellano; Roberto González-Garduño; Jorge Alfredo Cuéllar-Ordaz; Pedro Mendoza-de-Gives; Ma. Eugenia López-Arellano
Source:
Tropical animal health and production 2022 v.54 no.2 pp. 95
ISSN:
0049-4747
Subject:
Artemisia; Haemonchus contortus; Teladorsagia circumcincta; adults; albendazole; analysis of variance; animal health; body condition; color; deworming; eggs; fecal egg count; flocks; goats; hexane; mass spectrometry; mucosa; oral administration; placebos
Abstract:
... The objective of this study was to evaluate an n-hexane extract of Artemisia cina (Acn-h) as a natural anthelmintic treatment for periparturient goats naturally infected with the nematodes Haemonchus contortus and Teladorsagia circumcincta. A total of 200 periparturient Alpine and Nubian goats were used. Deworming criteria were based on the following parameters: fecal egg account (epg), ocular muc ...
DOI:
10.1007/s11250-022-03103-z

6. Biodegradation of anthelmintics in soils: does prior exposure of soils to anthelmintics accelerate their dissipation?

Author:
Stahis Lagos; Chrysovalantou Moutzoureli; Ifigenia Spiropoulou; Aggeliki Alexandropoulou; Panagiotis A. Karas; Anastasios Saratsis; Smaragda Sotiraki; Dimitrios G. Karpouzas
Source:
Environmental science and pollution research 2022 v.29 no.41 pp. 62404-62422
ISSN:
0944-1344
Subject:
adsorption; albendazole; barns; biodegradation; eprinomectin; farms; feces; gastrointestinal nematodes; ivermectin; pollution; research; sheep; soil; soil fumigation; total organic carbon
Abstract:
... Anthelmintics (AHs) control animal infections with gastrointestinal nematodes. They reach soil through animal faeces deposited on soils or through manuring. Although soil constitutes a major AH sink, we know little about the mechanisms controlling their soil dissipation. We employed studies with fumigated and non-fumigated soils collected from 12 sheep farms with a variable record of albendazole ( ...
DOI:
10.1007/s11356-022-19964-8

7. Community-based trial assessing the impact of annual versus semiannual mass drug administration with ivermectin plus albendazole and praziquantel on helminth infections in northwestern Liberia

Author:
Obiora A. Eneanya; Lincoln Gankpala; Charles W. Goss; Aaron T. Momolu; Enoch S. Nyan; Emmanuel B. Gray; Kerstin Fischer; Kurt Curtis; Fatorma K. Bolay; Gary J. Weil; Peter U. Fischer
Source:
Acta tropica 2022 v.231 pp. 106437
ISSN:
0001-706X
Subject:
Bancroftian filariasis; Ebolavirus; Onchocerca volvulus; Schistosoma mansoni; Wuchereria bancrofti; albendazole; endemic diseases; hookworms; ivermectin; onchocerciasis; praziquantel; regression analysis; schistosomiasis; Liberia
Abstract:
... We assessed the impact of three annual vs five semiannual rounds of mass drug administration (MDA) with ivermectin plus albendazole followed by praziquantel for the control or elimination of lymphatic filariasis (LF), onchocerciasis, soil-transmitted helminth (STH) infections and schistosomiasis in Lofa County, Liberia. The study started in 2012 and was interrupted in 2014 during the Ebola virus o ...
DOI:
10.1016/j.actatropica.2022.106437

8. Design, synthesis, and in vitro evaluation of thiosemicarbazone derivatives as anti-filarial agents

Author:
Ramkishore Matsa; Parameshwar Makam; R. Anilakumari; M. Sundharesan; Nisha Mathew; Tharanikkarasu Kannan
Source:
Experimental parasitology 2022 v.241 pp. 108363
ISSN:
0014-4894
Subject:
Setaria digitata; Wuchereria bancrofti; adults; albendazole; cattle; colorimetry; diethylcarbamazine; ivermectin; nematicides; parasites; parasitology; tetrazolium; viability
Abstract:
... Effective macrofilaricidal drugs are not commercially available, and in an endeavour to find out new macrofilaricidal agents, in this research work, thiosemicarbazone derivatives have been prepared and tested against adult Setaria digitata, a cattle filarial parasite, as a model nematode for the filarial parasite, Wuchereria bancrofti. Lipinski and Veber rules have been used to design these molecu ...
DOI:
10.1016/j.exppara.2022.108363

9. Determining the efficacy of Red Cell® in combination with anthelmintics against gastrointestinal nematode parasitism in sheep and goats

Author:
Niki C. Whitley; Joan M. Burke; Evelyn Smith; Kianna Lyte; Thomas H. Terrill
Source:
Small ruminant research 2022 v.209 pp. 106656
ISSN:
0921-4488
Subject:
Haemonchus contortus; albendazole; anemia; blood; death; disease susceptibility; eggs; gastrointestinal nematodes; levamisole; males; morbidity; mortality; moxidectin; parasitism; pastures; research
Abstract:
... Small ruminants are highly susceptible to infection with gastrointestinal nematodes (GIN), particularly Haemonchus contortus, a blood-feeder that can cause severe anemia and death losses in untreated animals. Anecdotal evidence has suggested that short-term treatment of heavily infected animals with Red Cell®, a vitamin and mineral supplement, in combination with anthelmintic drugs may reduce morb ...
DOI:
10.1016/j.smallrumres.2022.106656

10. The Effect of Season and Meteorological Conditions on Parasite Infection in Farm-Maintained Mouflons (Ovis aries Musimon)

Author:
B. Pilarczyk; A. Tomza-Marciniak; R. Pilarczyk; N. Sadowska; J. Udała; J. Kuba
Source:
Journal of parasitology research 2022 v.2022 pp. -
ISSN:
2090-0031
Subject:
Capillaria; Nematodirus; Ovis aries; Trichostrongylidae; air temperature; albendazole; deworming; farms; gastrointestinal system; herds; humidity; microclimate; mouflon; parasites; parasitology; parasitoses; pastures; research; risk; species diversity; spring; summer; winter
Abstract:
... Due to their limited environment, farm animals are at greater risk of parasitic infection than free-living animals, which also have greater natural resistance to parasitic diseases. The aim of the present study was to determine the influence of season and meteorological conditions (temperature and humidity) on the species composition and dynamics of parasitic infections in farmed mouflons. The stu ...
DOI:
10.1155/2022/1165782

11. Effects of Echinococcus multilocularis metacestodes infection and drug treatment on the activities of biotransformation enzymes in mouse liver

Author:
Qi Xin; Huanping Li; Miaomiao Yuan; Xiaoxia Song; Tao Jing
Source:
Parasitology international 2022 v.89 pp. 102563
ISSN:
1383-5769
Subject:
Echinococcus multilocularis; albendazole; biotransformation; drug therapy; echinococcosis; glutathione transferase; liver; metabolism; metacestodes; mice; oxidoreductases; parasitology; xenobiotics
Abstract:
... The changes of biotransformation enzymes will substantially affect the host's ability to metabolize drugs and other xenobiotic compounds. In order to further elucidate this process and promote the development in treatment of echinococcosis, we investigated the effects of Echinococcus multilocularis infection and drug treatment on biotransformation enzymes in mouse liver. In microsomal and cytosoli ...
DOI:
10.1016/j.parint.2022.102563

12. Effects of Ferula asafetida, closantel, albendazole, oxfendazole, and ivermectin against Haemonchus contortus in goats and sheep

Author:
Abdul Jabbar; Muhammad Zahid Iqbal; Muhammad Ashraf; Aneela Zameer Durrani; Hira Sajjad; Mohammed Nasiru Wana; Asad Ullah; Muhammad Imran; Muhammad Shair Zaman Ghauri; Hafiz Ishfaq Ahmad
Source:
Tropical animal health and production 2022 v.54 no.2 pp. 107
ISSN:
0049-4747
Subject:
Ferula; Haemonchus contortus; albendazole; animal health; closantel; drug resistance; feces; gender; herbal medicines; ivermectin; oxfendazole; parasites; plant extracts; sheep; Pakistan
Abstract:
... BACKGROUND: Haemonchosis is a fatal disease of small ruminants caused by the parasite Haemonchus contortus (H. contortus). The most common drugs used in the treatment of H. contortus include albendazole, oxfendazole, and ivermectin. However, as previously reported in the treatment of haemonchosis, these medicines have acquired drug resistance problems over time. Interestingly, natural plant compou ...
DOI:
10.1007/s11250-022-03111-z

13. Efficacy of Zingiber officinale and Cinnamomum zeylanicum extracts against experimental Trichinella spiralis infection

Author:
Marwa Ahmed Mohamed Salama; Nahed E. Mostafa; Naglaa Fathy Abd El-Aal; Howayda Said Fouad Moawad; Samar Kamel Hammad; Rasha Adel; Eman M. Mostafa
Source:
Journal of parasitic diseases 2022 v.46 no.1 pp. 24-36
ISSN:
0971-7196
Subject:
Cinnamomum verum; Trichinella spiralis; Zingiber officinale; adults; albendazole; blood serum; histopathology; humans; immunohistochemistry; muscles; prednisolone; public health; small intestine; therapeutics; traditional medicine; transmission electron microscopy; trichinosis; zoonoses
Abstract:
... Trichinellosis is a re-emerging zoonotic disease that has become a public health concern since its reported human outbreaks in many countries. The traditional therapy has many adverse effects in addition to the developing resistance. So, this necessitates finding effective natural alternatives. The current study targeted to assess the potential therapeutic effects of Zingiber officinale and Cinnam ...
DOI:
10.1007/s12639-021-01412-y

14. Egyptian propolis and selenium nanoparticles against murine trichinosis: a novel therapeutic insight

Author:
M.H. Sarhan; A. Farghaly; N.F. Abd El-Aal; S. Mohammed Farag; A. Ahmed Ali; T.I. Farag
Source:
Journal of helminthology 2022 v.96 pp. e50
ISSN:
1475-2697
Subject:
adults; albendazole; albino; histopathology; humans; immunohistochemistry; intestines; larvae; males; mice; morbidity; mortality; propolis; selenium; therapeutics; trichinosis; vascular endothelial growth factors; zoonoses
Abstract:
... Trichinosis is a serious zoonotic disease that causes human morbidity and mortality. New effective natural remedies with minimal side effects that are well tolerated are needed to treat both enteral and parenteral trichinosis. This study evaluated the efficacy of selenium (Se), Se nanoparticles (SeNPs) and Egyptian propolis compared with albendazole as antiparasitic, anti-inflammatory and anti-ang ...
DOI:
10.1017/S0022149X22000359

15. Elimination of Giardia duodenalis BIV in vivo using natural extracts in microbiome and dietary supplements

Author:
Caroline Rodrigues de Almeida; Renata Coltro Bezagio; Cristiane Maria Colli; Liara Izabela Lopes Romera; Ariana Ferrari; Mônica Lúcia Gomes
Source:
Parasitology international 2022 v.86 pp. 102484
ISSN:
1383-5769
Subject:
Camellia sinensis; Giardia lamblia; albendazole; black tea; feces; intestinal mucosa; metronidazole; microbiome; models; parasite load; parasites; parasitology; therapeutics; trophozoites
Abstract:
... In this study, a combination therapy of several natural products was evaluated in vivo in the Giardia duodenalis infection model. G. duodenalis infected mice were treated as follows: distilled water (infected control C+), BIOintestil® (BIO; natural products of Cymbopogon martinii and Zingiber officinale), MicrobiomeX® (MBX; extract of Citrus sinensis and Citrus paradisi), MBX + BIO, Camellia sinen ...
DOI:
10.1016/j.parint.2021.102484

16. Environmental circulation of the anthelmintic drug albendazole affects expression and activity of resistance-related genes in the parasitic nematode Haemonchus contortus

Author:
Diana Dimunová; Petra Matoušková; Martina Navrátilová; Linh Thuy Nguyen; Martin Ambrož; Ivan Vokřál; Barbora Szotáková; Lenka Skálová
Source:
Science of the total environment 2022 v.822 pp. 153527
ISSN:
0048-9697
Subject:
Haemonchus contortus; adults; albendazole; alfalfa; cytochrome P-450; drug resistance; environment; farms; feces; forage; glycosylation; helminths; oxidation; sheep; soil; thiabendazole; transferases
Abstract:
... Veterinary anthelmintics excreted from treated animals pass to soil, subsequently to plants and then to their consumers. This circulation might have various consequences, including drug-resistance promotion in helminths. The present study was designed to follow the effect of the environmental circulation of the common anthelmintic drug albendazole (ABZ) in real farm conditions on the parasitic nem ...
DOI:
10.1016/j.scitotenv.2022.153527

17. Evaluation of the mechanism of action of albendazole on adult rat lungworm (Angiostrongyluscantonensis)

Author:
John Jacob; Md Afjalus Siraj; Argon Steel; Ghee Tan; Susan Jarvi
Source:
Experimental parasitology 2022 v.242 pp. 108355
ISSN:
0014-4894
Subject:
Parastrongylus cantonensis; adults; albendazole; antimitotic agents; axonal transport; blood-brain barrier; cell viability; colorimetry; death; dose response; lungworms; mechanism of action; metabolites; metaphase; microtubules; nematicidal properties; neurons; parasitology; polymerization; rats; sulfoxides; toxicity testing; tubulin
Abstract:
... Albendazole is considered the anthelmintic of choice for the management of rat lungworm disease (neuroangiostrongyliasis), due to its broad spectrum of nematocidal activity and its ability to cross the blood-brain barrier. Albendazole binds to β-tubulins, preventing their polymerization into microtubules, thereby corrupting the cascade of cell division at metaphase, which ultimately leads to the d ...
DOI:
10.1016/j.exppara.2022.108355

18. Extended effects of an aggressive spring-time anthelmintic treatment on Haemonchus contortus in sheep from a North America cold winter climate

Author:
Adam Sarah; Pratiksha Khanal; Larry D. Holler; Susan W. Holler; Michael B. Hildreth
Source:
Small ruminant research 2022 v.206 pp. 106568
ISSN:
0921-4488
Subject:
Haemonchus contortus; Teladorsagia circumcincta; Trichostrongylus; adults; albendazole; climate; cold; eggs; levamisole; moxidectin; polymerase chain reaction; research; spring; winter
Abstract:
... Anthelmintic-resistant haemonchosis is a growing problem even among sheep located in winter climates lethal to the free-living third-stage larvae (L3) of Haemonchus contortus. As survival in cold climates is entirely dependent on tissue-dwelling fourth-stage larvae (L4s), an effective winter or spring-time anthelmintic treatment can significantly collapse H. contortus populations in cold winter re ...
DOI:
10.1016/j.smallrumres.2021.106568

19. Farmers' perception on the control of gastrointestinal parasites in organic and conventional sheep production in Sweden

Author:
Peter Halvarsson; Katarina Gustafsson; Johan Höglund
Source:
Veterinary Parasitology: Regional Studies and Reports 2022 v.30 pp. 100713
ISSN:
2405-9390
Subject:
Capreolus capreolus; Haemonchus contortus; albendazole; cattle; deworming; equipment; fecal examination; gastrointestinal nematodes; gastrointestinal system; herd size; ivermectin; land use; quarantine; questionnaires; risk factors; risk perception; surveys; veterinary parasitology; Sweden
Abstract:
... A questionnaire was sent to sheep owners in Sweden to get information about anthelmintic drug use. The survey also investigated how respondents experienced problems with gastrointestinal nematode infections (GIN) focusing on Haemonchus contortus. The response rate was 31% and included both conventional and organic farms. The use of anthelmintics was low (45%), among which a majority (76%) drenched ...
DOI:
10.1016/j.vprsr.2022.100713

20. Heme oxygenase-1 modulates brain inflammation and apoptosis in mice with angiostrongyliasis

Author:
Ke-Min Chen; Kuang-Ping Lan; Shih-Chan Lai
Source:
Parasitology international 2022 v.87 pp. 102528
ISSN:
1383-5769
Subject:
B-lymphocytes; Parastrongylus cantonensis; Western blotting; albendazole; apoptosis; blood-brain barrier; brain; caspase-3; cerebrospinal fluid; cobalt; enzyme-linked immunosorbent assay; gelatin; gelatinase B; heme oxygenase (biliverdin-producing); interleukin-10; interleukin-5; leukemia; lungworms; meningoencephalitis; necrosis; parasitology; permeability; protoporphyrin; rats; therapeutics
Abstract:
... The rat nematode lungworm Angiostrongylus cantonensis undergoes obligatory intracerebral migration in its hosts and causes eosinophilic meningitis or meningoencephalitis. Heme oxygenase 1 (HO-1) has several cytoprotective properties such as anti-oxidative, anti-inflammatory, and anti-apoptotic effects. HO-1 in brain tissues was induced in A. cantonensis-infected group and showed positive modulatio ...
DOI:
10.1016/j.parint.2021.102528

21. Identification and characterization of sirtuin enzymes in cestodes and evaluation of sirtuin inhibitors as new cestocidal molecules

Author:
Hugo Rolando Vaca; Ana María Celentano; María Agustina Toscanini; Alexander-Thomas Hauser; Natalia Macchiaroli; María Luján Cuestas; Alejandro David Nusblat; Wolfgang Sippl; María Celina Elissondo; Manfred Jung; Federico Camicia; Mara Cecilia Rosenzvit
Source:
International journal for parasitology 2022 v.52 no.5 pp. 317-329
ISSN:
0020-7519
Subject:
Echinococcus; Mesocestoides corti; active sites; albendazole; cysticercosis; dose response; echinococcosis; parasitology; sirtuins; transcription (genetics)
Abstract:
... Anti-parasitic treatment of neglected tropical diseases caused by cestodes such as echinococcosis and cysticercosis relies on a small number of approved anthelmintic drugs. Furthermore, the treatment is usually prolonged and often partially effective and not well tolerated by some patients. Therefore, the identification of novel drug targets and their associated compounds is critical. In this stud ...
DOI:
10.1016/j.ijpara.2021.12.002

22. Identification of promising nutraceuticals against filarial immune-modulatory proteins: insights from in silico and ex vivo studies

Author:
Vipin Kumar; Ayushi Mishra; Anchal Singh
Source:
RSC advances 2022 v.12 no.35 pp. 22542-22554
ISSN:
2046-2069
Subject:
Bancroftian filariasis; DNA; DNA fragmentation; adulticides; adults; albendazole; computer simulation; dietary supplements; diethylcarbamazine; dissociation; drug toxicity; emodin; immunomodulation; ivermectin; larvae; mechanism of action; molecular dynamics; naringin; nematicides; phosphopyruvate hydratase; tropical diseases; viability
Abstract:
... Lymphatic filariasis is a neglected tropical disease affecting over 863 million people in 47 countries of the world. The anti-filarial drugs, diethylcarbamazine, albendazole, and ivermectin, are effective only at the larval stages and have proven completely ineffective as adulticides. Besides this, a long-term use of these drugs is associated with several side effects including drug toxicity. Nutr ...
DOI:
10.1039/d2ra03287b

23. Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep

Author:
Raquel Diez; M. Jose Diez; Juan J. Garcia; Jose M. Rodríguez; Cristina Lopez; Nelida Fernandez; Matilde Sierra; Ana M. Sahagun
Source:
Animals 2022 v.12 no.4 pp. -
ISSN:
2076-2615
Subject:
absorption; albendazole; benzimidazole; bioavailability; high performance liquid chromatography; metabolites; oral administration; pharmacokinetics; sheep; sulfoxides
Abstract:
... The pharmacokinetic interaction between a benzimidazole (albendazole, ABZ) and a choleretic drug (menbutone, MEN) was evaluated in sheep. The plasma disposition of albendazole sulfoxide (ABZSO, active metabolite) and albendazole sulfone (ABZSO₂, inactive metabolite) was investigated following an oral administration of albendazole (ABZ) (5 mg/kg) alone or with menbutone (MEN) (intramuscular, 10 mg/ ...
DOI:
10.3390/ani12040463

24. In Vitro Anthelmintic Activity and Phytochemical Screening of Crude Extracts of Three Medicinal Plants against Haemonchus Contortus in Sheep at Haramaya Municipal Abattoir, Eastern Hararghe

Author:
Hassen Shamil Mumed; Dereje Regassa Nigussie; Kedir Sali Musa; Abdallahi Abdurahman Demissie
Source:
Journal of parasitology research 2022 v.2022 pp. -
ISSN:
2090-0031
Subject:
Croton macrostachyus; Haemonchus contortus; Nicotiana tabacum; Zingiber officinale; adults; albendazole; flavonoids; mortality; parasites; parasitology; research; rhizomes; secondary metabolites; slaughterhouses; terpenoids; therapeutics; viability
Abstract:
... The current study was carried out to evaluate the anthelmintic efficacy of crude methanolic extracts of leaves of Croton macrostachyus and Nicotiana tabacum and rhizome parts of Zingiber officinale on nematode parasite, Haemonchus contortus. For these objectives, adult worm mortality assay (AWMA) was conducted on adult H. contortus to investigate the in vitro adulticidal effect of crude extracts f ...
DOI:
10.1155/2022/6331740

25. In silico to In vivo development of a polyherbal against Haemonchus contortus

Author:
Anu Rahal; D.K. Sharma; Ashok Kumar; Nitika Sharma; Deen Dayal
Source:
Heliyon 2022 v.8 no.1 pp. e08789
ISSN:
2405-8440
Subject:
Butea monosperma; Catharanthus roseus; Haemonchus contortus; Vitex negundo; albendazole; antioxidants; betulinic acid; chloroform; colchicine; computer simulation; depolymerization; dose response; electrostatic interactions; ethyl acetate; glutamate dehydrogenase; hexane; hydrogen; hydrophobic bonding; hydrophobicity; immunomodulation; larvicides; ligands; methanol; parasites; pharmacokinetics; prediction; small ruminants; tubulin; ursolic acid; vinblastine; vincristine
Abstract:
... Haemonchus contortus is a major constraint in the development of small ruminant subsector due to significant production losses incurred by it. The present study explores the antiparasitic potential of three anthelmintic plants (Butea monosperma, Vitex negundo and Catharanthus roseus (L.) G.Don) against H. contortus taking albendazole as the standard. In silico molecular docking and pharmacokinetic ...
DOI:
10.1016/j.heliyon.2022.e08789

26. In vitro and in vivo anthelmintic effects of Sterospermum kunthianum (Cham-Holl) leaf extract against Ascaridia galli in experimentally infected broiler chickens

Author:
Kyari Stephen; Ologunja Joseph Ajanusi; Mohammed Musa Suleiman; Ochuko Orakpoghenor; Matthew Ogwiji
Source:
Journal of parasitic diseases 2022 v.46 no.1 pp. 152-158
ISSN:
0971-7196
Subject:
Ascaridia galli; acute toxicity; albendazole; death; eggs; ethyl acetate; hexane; histopathology; leaf extracts; methanol; necrosis; oral administration
Abstract:
... This study was to assess the anthelminthic potential of Sterospermum kunthianum leaf extract against Ascaridia galli in experimentally infected broiler chickens. The extract and fractions were evaluated for in vitro inhibition and in vivo anthelmintic effects. Acute toxicity studies of extract revealed no sign of toxicity or death in birds at oral dose range of 1000–5000 and was considered safe. T ...
DOI:
10.1007/s12639-021-01426-6

27. In vitro metabolic stress induced by nitazoxanide and flubendazole combination in Taenia crassiceps cysticerci

Author:
Nayana Ferreira de Lima; Guaraciara de Andrade Picanço; Tatiane Luiza Costa; Marina Clare Vinaud
Source:
Experimental parasitology 2022 v.238 pp. 108265
ISSN:
0014-4894
Subject:
Taenia crassiceps; acidosis; albendazole; catabolism; chromatography; cysticerci; cysticercosis; excretion; fermentation; flubendazole; gluconeogenesis; glycolysis; metabolites; models; oxidation; parasitology; praziquantel; protein metabolism; tricarboxylic acid cycle
Abstract:
... Taenia crassiceps is often used as experimental model for T. solium cysticercosis studies. Currently cysticercosis antiparasitic treatment is based on albendazole and praziquantel which may present side effects and parasitic resistance. The search for other antiparasitic drugs is necessary. Nitazoxanide (NTZ) and flubendazole (FLB) are broad spectrum antiparasitic drugs that present anti-cysticerc ...
DOI:
10.1016/j.exppara.2022.108265

28. In vitro ovicidal activity of Brongniartia montalvoana against small ruminant gastrointestinal nematodes

Author:
J.A. Cortes-Morales; A. Olmedo-Juárez; M. González-Cortazar; A. Zamilpa; M.A. López-Arellano; E.A. Ble-González; D. Tapia-Maruri; G. Flores-Franco; D.O. Salinas-Sánchez
Source:
Experimental parasitology 2022 v.240 pp. 108336
ISSN:
0014-4894
Subject:
Fabaceae; Haemonchus; Oesophagostomum; Trichostrongylus; albendazole; bioassays; coumarin; eggs; ethyl acetate; ferulic acid; gastrointestinal nematodes; high performance liquid chromatography; ivermectin; levamisole; luteolin; methanol; nutritive value; ovicides; p-coumaric acid; parasitology; separation; small ruminants; sulfoxides; thiabendazole; thin layer chromatography
Abstract:
... Several plants of the Fabaceae family have been assessed regarding their high nutritional value and anthelmintic properties. The ovicidal effect of the hydroalcoholic extract (Bm-HAE) and subfractions from the aerial parts of Brongniartia montalvoana (Fabaceae) against a mixed strain of gastrointestinal nematodes (GIN) (Haemonchus spp., Trichostrongylus spp. and Oesophagostomum spp.) resistant to ...
DOI:
10.1016/j.exppara.2022.108336

29. In vitro protoscolicidal effects of lithocholic acid on protoscoleces of Echinococcus granulosus and its mechanism

Author:
Ya Xu; Wenjuan Qing; Zhen Wang; Lin Chen; Linyao Wang; Hailong Lv; Yufeng Jiang
Source:
Experimental parasitology 2022 v.239 pp. 108280
ISSN:
0014-4894
Subject:
Echinococcus granulosus; albendazole; apoptosis; caspase-3; dose response; echinococcosis; enzyme-linked immunosorbent assay; eosin; lithocholic acid; microstructure; mitochondria; oxidative stress; parasitology; protoscoleces; survival rate; ultrastructure
Abstract:
... Surgery has been found to be the best choice of treatment for hydatidosis. However, leakage of cyst contents during surgery is the foremost reason for recurrence of hydatidosis. In this study, we investigated the in vitro efficacy of lithocholic acid (LCA) against Echinococcus granulosus protoscoleces. The protoscoleces were divided into a control group, an albendazole (ABZ) positive control group ...
DOI:
10.1016/j.exppara.2022.108280

30. In vivo efficacy of pyrantel pamoate as a post-exposure prophylactic for rat lungworm (Angiostrongylus cantonensis)

Author:
Jacob John; Steel Argon; Kaluna Lisa; Steven Hess; Israel Leinbach; Carmen Antaky; Robert Sugihara; Lindsey Hamilton; Peter Follett; Kathleen Howe; Steven Jacquier; Supakit Wongwiwatthananukit; Susan Jarvi
Source:
International Journal for Parasitology: Drugs and Drug Resistance 2022 v.19 no. pp. 1-5
ISSN:
2211-3207
Subject:
Parastrongylus cantonensis; albendazole; digestive tract; drug resistance; ingestion; lungworms; meningitis; parasitology; patients; peristalsis; pyrantel; rats
Abstract:
... Rat lungworm (Angiostrongylus cantonensis) is a neurotropic nematode, and the leading cause of eosinophilic meningitis worldwide. The parasite is usually contracted through ingestion of infected gastropods, often hidden in raw or partially cooked produce. Pharmaceutical grade pyrantel pamoate was evaluated as a post-exposure prophylactic against A. cantonensis. Pyrantel pamoate is readily availabl ...
Handle:
10113/7770563
DOI:
10.1016/j.ijpddr.2022.04.002
CHORUS:
10.1016/j.ijpddr.2022.04.002

31. Integrated transmission assessment surveys (iTAS) of lymphatic filariasis and onchocerciasis in Cross River, Taraba and Yobe States, Nigeria

Author:
Ifeoma N. Anagbogu; Yisa A. Saka; Olabanji Ahmed Surakat; Chukwu Okoronkwo; Emmanuel Davies; Philip Oyale; Uwem Friday Ekpo; Uche V. Amazigo; Kira Barbre; Micheal Igbe; Audrey Nyior; Solomon M Jacob; Uduak Gideon Nteun; Zaiyanatu Abubakar Umar
Source:
Parasites & vectors 2022 v.15 no.1 pp. 201
ISSN:
1756-3305
Subject:
Bancroftian filariasis; albendazole; ivermectin; local government; monitoring; onchocerciasis; rivers; Nigeria
Abstract:
... BACKGROUND: Integrated transmission assessment surveys (iTAS) have been recommended for evaluation of the transmission of both lymphatic filariasis (LF) and onchocerciasis as the prevalence of both diseases moves toward their respective elimination targets in Nigeria. Therefore, we conducted an iTAS between May and December 2017 in five local government areas (LGAs), also known as implementation u ...
DOI:
10.1186/s13071-022-05302-x

32. Intraperitoneal and intracranial experimental cysticercosis present different metabolic preferences after treatment with isolated or combined albendazole and nitazoxanide

Author:
Guaraciara de Andrade Picanço; Nayana Ferreira de Lima; Taynara Cristina Gomes; Daniella de Sousa Mendes Moreira Alves; Tatiane Luísa da Costa; Marina Clare Vinaud
Source:
Acta tropica 2022 v.226 pp. 106264
ISSN:
0001-706X
Subject:
Taenia crassiceps; albendazole; catabolism; central nervous system; chromatography; cysticerci; cysticercosis; fermentation; glycolysis; humans; mitochondria; models; parasites; protein metabolism; public health; spectroscopy; succinate dehydrogenase (quinone)
Abstract:
... Cysticercosis is a zoonotic public health issue especially severe when the parasite is in the central nervous system although it may be found all over the human organism. Taenia crassiceps cysticerci inoculated in mice is the experimental model used to study cysticercosis. The most used cysticercosis treatment is with albendazole (ABZ). Nitazoxanide (NTZ) has been experimentally tested against thi ...
DOI:
10.1016/j.actatropica.2021.106264

33. Investigation of the effect of curcumin on oxidative stress, local inflammatory response, COX-2 expression, and microvessel density in Trichinella spiralis induced enteritis, myositis and myocarditis in mice

Author:
A. M. R. Hamed; I. R. Abdel-Shafi; M. D. A. Elsayed; A. M. Mahfoz; S. E. Tawfeek; M. S. A. Abdeltawab
Source:
Helminthologia 2022 v.59 no.1 pp. 18-36
ISSN:
1336-9083
Subject:
Trichinella spiralis; adjuvants; albendazole; anti-inflammatory activity; antioxidants; blood serum; curcumin; enteritis; histopathology; immunohistochemistry; inflammation; malondialdehyde; microvessels; myocarditis; myocardium; myositis; oxidative stress; parasite load; prostaglandin synthase; skeletal muscle; small intestine; therapeutics; trichinosis
Abstract:
... Curcumin exerts anti-oxidant and anti-inflammatory properties that have proven to be of value in the management of several parasitic infections. Investigation of the value of curcumin in the management of trichinosis either alone or as an adjuvant to albendazole. Animals received either curcumin 150 mg/kg, curcumin 300 mg/kg, albendazole 50 mg/ kg or combined curcumin 150mg/kg and albendazole 50 m ...
DOI:
10.2478/helm-2022-0002

34. Measurement and correlation of solubility data for albendazole in ten pure solvents and two binary solvent systems from 278.15 K to 323.15 K

Author:
Yunjie Wu; Yang Chen; Ke Xu; Nanxin Li; Hualin Fu; Xianxiang Wang; Funeng Xu; Haohuan Li; Gang Shu; Juchun Lin; Xiaoxia Liang; Wei Zhang
Source:
Sustainable chemistry and pharmacy 2022 v.27 pp. 100673
ISSN:
2352-5541
Subject:
Gibbs free energy; albendazole; enthalpy; entropy; equations; green chemistry; models; solubility; solvents; spectroscopy; temperature
Abstract:
... The equilibrium solubility of albendazole (ABZ) in ten single solvents and two binary solvent mixtures of different ratio was measured by a typical static method combined with ultraviolet (UV) spectrophotometry within the temperature range from 278.15 K to 323.15 K. Meanwhile, the modified Apelblat model, Van't Hoff equation and λh equation were used to correlate the solubility data of ABZ in pure ...
DOI:
10.1016/j.scp.2022.100673

35. Metabolic stability of glyphosate and its environmental metabolite (aminomethylphosphonic acid) in the ruminal content of cattle

Author:
Karen Larsen; Adrián Lifschitz; Rocío Fernández San Juan; Guillermo Virkel
Source:
Food additives & contaminants 2022 v.39 no.4 pp. 740-751
ISSN:
1944-0057
Subject:
albendazole; anaerobiosis; biotransformation; digestive tract; feces; feeds; fluorescence; glyphosate; metabolites; slaughterhouses; sulfoxides; viability; xenobiotics
Abstract:
... Glyphosate (GLY) is one of the most commonly used herbicides worldwide. Both GLY and aminomethylphosphonic acid (AMPA), its main degradation product, may be present in feedstuffs offered to dairy cows. Although the major proportions of ingested GLY and AMPA are eliminated with faeces, a potential degradation of GLY to AMPA in the rumen of dairy cows has been suggested. Considering that the rumen p ...
DOI:
10.1080/19440049.2022.2032382

36. Metformin improves the therapeutic efficacy of low-dose albendazole against experimental alveolar echinococcosis

Author:
Julia A. Loos; Magalí Coccimiglio; María Celeste Nicolao; Christian Rodriguez Rodrigues; Andrea C. Cumino
Source:
Parasitology 2022 v.149 no.1 pp. 138-144
ISSN:
1469-8161
Subject:
Echinococcus multilocularis; albendazole; disease severity; drug therapy; echinococcosis; glucose; inoculum; metacestodes; metformin; models; parasites; parasitology; toxicity
Abstract:
... Alveolar echinococcosis (AE) is a severe disease caused by Echinococcus multilocularis. Its chemotherapeutic treatment is based on benzimidazoles, which are rarely curative and cause several adverse effects. Therefore, it is necessary to develop alternative and safer chemotherapeutic strategies against AE. It has previously been shown that metformin (Met) exhibits considerable in vivo activity on ...
DOI:
10.1017/S0031182021001633

37. Multi-residue methodology for quantification of antiparasitics in hen eggs by LC-MS/MS: development, validation and application to 348 samples from Brazil

Author:
Caroline A. Tomaszewski; Fabiano Barreto; Lucas S. Barnet; Louise Jank; Tania Mara Pizzolato
Source:
Food additives & contaminants 2022 v.39 no.8 pp. 1412-1423
ISSN:
1944-0057
Subject:
acetonitrile; albendazole; eggs; fenbendazole; fipronil; ivermectin; maximum residue limits; mebendazole; metabolites; oxibendazole; sodium chloride; solvents; sulfoxides; Brazil
Abstract:
... Analytical methodology for quantification of 15 antiparasitic drugs and their respective metabolites in laying hen eggs was optimized and validated. The method uses acetonitrile as solvent extraction, sodium chloride for salting-out, low-temperature purification and analysis by LC-MS/MS. A total of 348 egg samples were collected in 11 states of Brazil and 50% of the total samples presented antipar ...
DOI:
10.1080/19440049.2022.2093984

38. Oxfendazole induces protein catabolism and gluconeogenesis in experimental neurocysticercosis

Author:
Laila Timina Bueno Correia; Nayana Ferreira de Lima; Taynara Cristina Gomes; Carlos Henrique De Sousa Guerra; Tatiane Luiza Costa; Marina C Vinaud
Source:
Acta tropica 2022 v.234 pp. 106571
ISSN:
0001-706X
Subject:
Taenia crassiceps; albendazole; central nervous system; cysticerci; epilepsy; fermentation; gluconeogenesis; glycolysis; host-parasite relationships; lactic acid; metabolites; models; neurocysticercosis; oral administration; oxfendazole; oxidation; praziquantel; propionic acid; protein metabolism; public health; tricarboxylic acid cycle
Abstract:
... Neurocysticercosis (NCC) is an endemic public health disease of the central nervous system highly related to epilepsy and seizures. Taenia crassiceps is an experimental model used for NCC and biochemical studies of the host-parasite relationship. For the past 50 years the NCC therapeutic treatment is performed with albendazole (ABZ) and praziquantel which opens a gap for new therapies due to paras ...
DOI:
10.1016/j.actatropica.2022.106571

39. Pharmacological characterization of geraniol in sheep and its potential use in the control of gastrointestinal nematodes

Author:
María Victoria Miró; Livio Martins Costa-Júnior; Luis Ignacio Alvarez; Carlos Lanusse; Guillermo Virkel; Adrián Lifschitz
Source:
Veterinary and Animal Science 2022 v.18 pp. 100269
ISSN:
2451-943X
Subject:
Haemonchus contortus; albendazole; animal science; fecal egg count; gastrointestinal nematodes; gastrointestinal system; geraniol; liver microsomes; pharmacokinetics; phytochemicals; sheep; sulfoxides
Abstract:
... Geraniol (GNL) was effective against gastrointestinal nematodes in vitro; nevertheless, the anthelmintic effect of phytochemicals combined with synthetic drugs has been little explored in vivo. This article characterized in vitro / in vivo the pharmacological features of GNL in sheep as well as its pharmacokinetic interaction with albendazole (ABZ). Additionally, the in vivo efficacy of GNL agains ...
DOI:
10.1016/j.vas.2022.100269

40. Phenotypic changes of Trichinella spiralis treated by Commiphora molmol,Lepidium sativum, and Albendazole: in vitro study

Author:
G. L. Abuelenain; Z. H. Fahmy; A. M. Elshennawy; E. H. A. Selim; M. Elhakeem; K. M. A. Hassanein; S. M. Awad
Source:
Helminthologia 2022 v.59 no.1 pp. 37-45
ISSN:
1336-9083
Subject:
Commiphora myrrha; Lepidium sativum; Trichinella spiralis; absorption; albendazole; experimental design; herbal medicines; muscles; myrrh resin; parasites; phenotype; survival rate; therapeutics; trichinosis
Abstract:
... Trichinellosis is a nematode-causing disease distinguished by its continuous transmission in the carnivores and omnivores. Despite effective eradication of the enteral forms, conventional drugs fail to eliminate the migrating and muscle ones. Over the past years, researchers intensified the work on herbal medicines as alternatives or aids to albendazole, the reference drug. This research hypothesi ...
DOI:
10.2478/helm-2022-0005

41. Phenotypic characterization and multiple resistance analysis in an experimentally selected albendazole-resistant hookworm isolate

Author:
Celi da Silva Medeiros; Lara Ribeiro de Almeida; Élida Mara Leite Rabelo; Luis Fernando Viana Furtado
Source:
Experimental parasitology 2022 pp. 108393
ISSN:
0014-4894
Subject:
Ancylostoma ceylanicum; adults; albendazole; blood serum; cross resistance; eggs; females; genotype; hematocrit; hemoglobin; hookworms; host-parasite relationships; ivermectin; males; mebendazole; morphometry; parasitology; pathogenicity; phenotype
Abstract:
... For some nematodes, alterations that leads to a resistance genotype may be accompanied by other modifications, causing changes in the biology of the parasite, although the exact mechanisms of this relationship are still not very clear. These alterations can have deleterious effects on their survival or even potentiate their pathogenicity. In this study a phenotypic characterization was carried out ...
DOI:
10.1016/j.exppara.2022.108393

42. Potential therapeutic effect of platelet-rich plasma and albendazole on the muscular phase of experimental Trichinella spiralis infection

Author:
Fatma M.A. Eissa; Ahmed H.A. Eassa; Rabab S. Zalat; Mohamed S. Negm; Marwa A. Elmallawany
Source:
Food and Waterborne Parasitology 2022 v.28 pp. e00180
ISSN:
2405-6766
Subject:
Trichinella spiralis; albendazole; drug therapy; fibrosis; histopathology; inflammation; muscles; parasitology; trichinosis
Abstract:
... Trichinellosis is a food-borne parasitic infection causing muscle damage. This study aimed to detect the potential therapeutic effect of platelet-rich plasma (PRP) alone or in combination with albendazole (ALB) on the muscular phase of experimental Trichinella infection in rats. The study was conducted on 70 rats divided into four main groups: healthy non-infected non-treated rats, non-infected ra ...
DOI:
10.1016/j.fawpar.2022.e00180

43. Production responses in adult ewes to long-acting anthelmintic treatment pre-mating: relationship with body condition score

Author:
Dave M. Leathwick; Chris M. Miller; Tania S. Waghorn; Shen-Yan Hea; Paul M. Candy
Source:
New Zealand journal of agricultural research 2022 v.65 no.2-3 pp. 188-201
ISSN:
1175-8775
Subject:
Texel; abamectin; adults; agricultural research; albendazole; body condition; cobalt; ewes; liveweight gain; moxidectin; selenium; New Zealand
Abstract:
... A trial was conducted to investigate the response of mixed age ewes of different body condition scores (BCS) to a pre-mating treatment with long-acting anthelmintics. Three hundred Poll–Dorset Texel cross ewes were divided into three groups of 100 and treated pre-mating with either a 100-day controlled-release capsule containing abamectin, albendazole, selenium and cobalt, a long-acting injectable ...
DOI:
10.1080/00288233.2020.1801770

44. Regulation of apoptosis and autophagy by albendazole in human colon adenocarcinoma cells

Author:
Young Yun Jung; Seung Ho Baek; In Jin Ha; Kwang Seok Ahn
Source:
Biochimie 2022 v.198 pp. 155-166
ISSN:
0300-9084
Subject:
acridine orange; adenocarcinoma; albendazole; antioxidants; apoptosis; autophagy; carcinogenesis; cell cycle; colon; colorectal neoplasms; cysteine; cytotoxicity; humans; immunocytochemistry; neoplasm cells
Abstract:
... Albendazole (ABZ) was initially introduced as an anthelmintic, however, many studies have reported with its anticancer effects. We investigated the anti-tumor effects of ABZ in vitro in human colon adenocarcinoma HCT-15, HCT-116, HT-29, and SW480 cell lines in this study. The cytotoxicity of ABZ was analyzed in colon adenocarcinoma cell lines and normal CCD18Co cells. We found that ABZ induced the ...
DOI:
10.1016/j.biochi.2022.04.014

45. A Retrospective Study of the Efficacy of Albendazole and Diethylcarbamazine for the Treatment of Human Toxocariasis

Author:
Jean-François Magnaval; Judith Fillaux; Antoine Berry
Source:
Pathogens 2022 v.11 no.7 pp. -
ISSN:
2076-0817
Subject:
albendazole; blood serum; diethylcarbamazine; drug therapy; eosinophilia; humans; mycology; parasitology; retrospective studies; toxocariasis
Abstract:
... In the Department of Parasitology and Mycology of Toulouse University Hospitals, patients presenting with common/covert toxocariasis were treated either with albendazole (39 cases) or with diethylcarbamazine (32 cases). Albendazole (ABZ) was given at 10 mg/kg b/w daily for 14 days, and diethylcarbamazine (DEC) was given at 4 mg/kg b/w daily for 21 days. In both groups, follow-up consultations occu ...
DOI:
10.3390/pathogens11070813

46. Signs of multiple anthelmintic resistance in sheep gastrointestinal nematodes in Sweden

Author:
Johan Höglund; Paulius Baltrušis; Nizar Enweji; Katarina Gustafsson
Source:
Veterinary Parasitology: Regional Studies and Reports 2022 pp. 100789
ISSN:
2405-9390
Subject:
DNA; Haemonchus; albendazole; droplets; farms; fecal egg count; fenbendazole; gastrointestinal nematodes; ivermectin; levamisole; moxidectin; risk; sheep; veterinary parasitology; Sweden
Abstract:
... Gastrointestinal nematodes in small ruminants are clinically and economically important parasites that often are controlled with anthelmintics. In this study, we compiled information on the anthelmintic efficacy collected on sheep farms according to routines established by Farm & Animal Health in Sweden. The efficacies of benzimidazoles (i.e. albendazole or fenbendazole, n = 30), ivermectin (n = 4 ...
DOI:
10.1016/j.vprsr.2022.100789

47. Status and prospect of novel treatment options toward alveolar and cystic echinococcosis

Author:
Sibo Wang; Yibo Ma; Weishan Wang; Yi Dai; Haohao Sun; Jing Li; Shan Wang; Feng Li
Source:
Acta tropica 2022 v.226 pp. 106252
ISSN:
0001-706X
Subject:
Echinococcus granulosus; albendazole; echinococcosis; experimental design; mebendazole; models; pharmacodynamics; therapeutics; zoonoses
Abstract:
... Cystic echinococcosis (CE) and alveolar echinococcosis (AE) are the two most important global parasitic infectious diseases caused by species of Echinococcus granulosus and E. multilocularis, respectively. Although numerous trials have been performed in search of novel therapeutic options to curb the neglected zoonosis, no other nonsurgical options are currently available to replace the licensed a ...
DOI:
10.1016/j.actatropica.2021.106252

48. Therapeutic efficacy and bioaccumulation of albendazole in the treatment of tambaqui (Colossoma macropomum) parasitized by acanthocephalan (Neoechinorhynchus buttnerae)

Author:
Rafaelle Pereira Cordeiro; Patrícia Aparecida de Campos Braga; Claudio Martin Jonsson; Franmir Rodrigues Brandão; Edsandra Campos Chagas; Felix Guillermo Reyes Reyes
Source:
Aquaculture research 2022 v.53 no.4 pp. 1446-1455
ISSN:
1355-557X
Subject:
Colossoma macropomum; Neoechinorhynchus; albendazole; aquaculture; bioaccumulation; ethyl cellulose; fish; fish feeds; liquid chromatography; medicated feeds; metabolites; muscles; research; risk; tandem mass spectrometry; therapeutics
Abstract:
... The therapeutic efficacy of different doses of albendazole (ABZ) in the treatment of infection by acanthocephalan (Neoechinorhynchus buttnerae) in tambaqui (Colossoma macropomum) was evaluated. The bioaccumulation of ABZ and its main metabolites in the target tissue (muscle plus skin in natural proportions) was also evaluated. The fish received a daily dose of 10, 20 or 30 mg ABZ kg⁻¹ bw via medic ...
DOI:
10.1111/are.15677

49. Therapy and Prevention for Human Toxocariasis

Author:
Jean-François Magnaval; Emilie Bouhsira; Judith Fillaux
Source:
Microorganisms 2022 v.10 no.2 pp. -
ISSN:
2076-2607
Subject:
albendazole; epidemiology; humans; laboratory diagnosis; pathophysiology; poverty; therapeutics; toxocariasis; veterinary medicine; zoonoses
Abstract:
... For the last four decades, knowledge about human toxocariasis with regard to its epidemiology, pathophysiology, clinical spectrum, and imaging or laboratory diagnosis has substantially progressed. Knowledge about specific therapy with anthelmintics has lagged behind. To date, only four drugs are registered for human use, and their efficacy has rarely been assessed in prospective controlled trials. ...
DOI:
10.3390/microorganisms10020241

50. Trichostrongyle infections in domestic ruminants from Egypt: A systematic review and meta-analysis

Author:
Ibrahim Abbas; Michael B. Hildreth
Source:
Veterinary Parasitology: Regional Studies and Reports 2022 v.34 pp. 100761
ISSN:
2405-9390
Subject:
Haemonchus contortus; albendazole; cattle; confidence interval; eggs; epidemiology; meta-analysis; parasites; sheep; systematic review; veterinary parasitology; winter; Egypt
Abstract:
... Trichostrongylid nematodes can cause serious loss in the livestock economy; nevertheless, infections with these ubiquitous nematodes in animals from developing countries are largely neglected. The present paper provides a systematic review and meta-analysis to evaluate the status of trichostrongyle infections in domestic ruminants from Egypt. Out of 626 collected publications, 118 were defined sui ...
DOI:
10.1016/j.vprsr.2022.100761

51. Ultrastructural tegumental changes of Trichinella spiralis adult and larval stages after in vitro exposure to Allium sativum

Author:
Noha Abou Hussien; Mona Faheem; Eman Sweed; Asmaa Ibrahim
Source:
Experimental parasitology 2022 v.239 pp. 108314
ISSN:
0014-4894
Subject:
Allium sativum; Trichinella spiralis; adults; albendazole; furrows; larvae; mortality; parasitology; therapeutics; trichinosis
Abstract:
... Albendazole (ALB) is the most used therapeutic drug for trichinellosis treatment, but it has many drawbacks. Hence, the search for alternative natural compounds is a goal for researchers. The present work aimed to test the in vitro anthelmintic effect of Tomex (Allium sativum) against adult and muscular larva of Trichinella spiralis (T. spiralis). We incubated adult forms and muscular larvae of T. ...
DOI:
10.1016/j.exppara.2022.108314

52. The combination of carvacrol and albendazole enhanced the efficacy of monotherapy in experimental alveolar echinococcosis

Author:
Lurdes Milagros Lopez; Patricia Eugenia Pensel; Julia Fabbri; Clara María Albani; Natalia Elissondo; Guillermo Gambino; María Celina Elissondo
Source:
Acta tropica 2022 v.225 pp. 106198
ISSN:
0001-706X
Subject:
Echinococcus multilocularis; albendazole; carvacrol; echinococcosis; larvae; metacestodes; parasites; resection; zoonoses
Abstract:
... Alveolar echinococcosis is a helminthic zoonosis caused by the larval stage of Echinococcus multilocularis. When surgical resection of the parasite is not feasible, pharmacological treatment with albendazole is the only option. Due to the difficulties in achieving the success of treatment, it is necessary to find new drugs to improve the treatment of this disease. In the present work, the efficacy ...
DOI:
10.1016/j.actatropica.2021.106198

53. The effect of Spondias mombin L. against Strongyloides venezuelensis: An in vitro approach

Author:
Paula Berna da Silva Medeiros; Tiago Manuel Fernandes Mendes; Vera Lucia Garcia; Rosimeire Nunes De Oliveira; Leticia Bastos Duart; Silmara Marques Allegretti
Source:
Acta tropica 2022 v.234 pp. 106617
ISSN:
0001-706X
Subject:
Spondias mombin; Strongyloides stercoralis; Strongyloides venezuelensis; albendazole; fractionation; ivermectin; models; mortality; parasites; phenol; polyvinylpyrrolidone; strongyloidiasis; therapeutics; thin layer chromatography; tropical diseases
Abstract:
... Strongyloidiasis is a neglected tropical disease mainly caused by the nematode parasite Strongyloides stercoralis. Current treatment consists in the administration of ivermectin or, alternatively, albendazole (or analogues). Concerns regarding these drugs’ irregular cure rates and side effects, raise a need for therapeutic alternatives. In this study, we tested the in vitro effect of Spondias momb ...
DOI:
10.1016/j.actatropica.2022.106617

54. The potentials of Calotropis procera against filarial elephantiasis: an in-silico approach

Author:
Aswin Mohan; Shanitha Shaji; Sunitha Padmanabhan; Shahanas Naisam; Nidhin Sreekumar
Source:
Journal of parasitic diseases 2022 v.46 no.2 pp. 384-394
ISSN:
0971-7196
Subject:
Bancroftian filariasis; Brugia malayi; Calotropis procera; Lewis acids; albendazole; alopecia; computer simulation; computer software; diethylcarbamazine; glutathione transferase; hematophagous arthropods; ivermectin; medicinal plants; molecular dynamics; nausea
Abstract:
... Lymphatic filariasis is one of the major diseases that belong to the category of neglected tropical illness. Filarial nematodes are the cause of the disease and are transmitted to humans via blood-feeding arthropod vectors. Drugs such as Albendazole, Ivermectin and diethylcarbamazine are administered either individually or in combination to overcome the progress of the lymphatic filariasis. These ...
DOI:
10.1007/s12639-021-01456-0

55. An ultrahigh-performance liquid chromatography-fluorescence detection (UHPLC-FLD) method for simultaneous determination of albendazole and its three metabolites in poultry eggs

Author:
Fanxun Guan; Zhaoyuan He; Yayun Tang; Pengfei Gao; Lan Chen; Yawen Guo; Kaizhou Xie
Source:
Journal of food composition and analysis 2022 pp. 104959
ISSN:
0889-1575
Subject:
albendazole; chemical species; chickens; ducks; fluorescence; food composition; geese; intestines; metabolites; sulfoxides; ultra-performance liquid chromatography
Abstract:
... Albendazole (ABZ) is widely used in the treatment of animal intestinal parasitic infections. This study has established a method of ultrahigh-performance liquid chromatography coupled with fluorescence detection for the simultaneous determination of ABZ and its three metabolites (albendazole, albendazole sulfone, albendazole sulfoxide, albendazole-2-aminosulfone) in poultry (chicken, duck, and goo ...
DOI:
10.1016/j.jfca.2022.104959

56. β-cyclodextrin dendritic derivatives as permeation mediators to enhance the in vitro albendazole cysticidal activity by the improvement of the diffusion component

Author:
Luis José López-Méndez; Francisca Palomares-Alonso; Iliana González-Hernández; Helgi Jung-Cook; Neyra Citlali Cabrera-Quiñones; Patricia Guadarrama
Source:
RSC advances 2022 v.12 no.36 pp. 23153-23161
ISSN:
2046-2069
Subject:
albendazole; cysticerci; drug resistance; models; nanocarriers; pH; permeability; solubility
Abstract:
... The improvement of permeation of drugs across parasites' membranes to promote their diffusion component represents a challenge to achieve better therapeutic effects, including the avoidance of drug resistance. In the context of medicinal chemistry, suitable structural modifications can be made, either on a drug or a nanocarrier, to trigger different mechanisms that promote the influx across membra ...
DOI:
10.1039/d2ra03314c

57. Acute fasciolosis in an alpaca: a case report

Author:
C. J. Hayes; P. J. O’Brien; A. Wolfe; S. Hoey; C. Chandler; V. Rhodes; C. I. Carty; I. M. Piras; E. G. Ryan
Source:
BMC veterinary research 2021 v.17 no.1 pp. 215
ISSN:
1746-6148
Subject:
Camelidae; Fasciola hepatica; abdomen; albendazole; alpacas; anemia; blood; blood transfusion; case studies; cholestasis; colic; dexamethasone; disease course; enzyme activity; fascioliasis; forestomach; inflammation; intestinal obstruction; liver; males; peritonitis; radiography; triclabendazole; ultrasonics; veterinarians; veterinary clinics; Ireland
Abstract:
... BACKGROUND: The popularity of new world camelids, particularly alpacas, is growing rapidly in Ireland, presenting a clinical challenge to veterinary practitioners who may not have worked with these species previously. To the authors’ knowledge, the clinical course of a case of acute fasciolosis in an alpaca has not previously been reported, and fasciolosis has not been reported at all in alpacas i ...
DOI:
10.1186/s12917-021-02921-x

58. Albendazole Nanocrystal-Based Dissolving Microneedles with Improved Pharmacokinetic Performance for Enhanced Treatment of Cystic Echinococcosis

Author:
Andi Dian Permana; Alejandro J. Paredes; Fabiana Volpe Zanutto; Muh. Nur Amir; Ismail Ismail; Muh. Akbar Bahar; Sumarheni; Santiago Daniel Palma; Ryan F. Donnelly
Source:
ACS applied materials & interfaces 2021 v.13 no.32 pp. 38745-38760
ISSN:
1944-8252
Subject:
Echinococcus; albendazole; bioavailability; crystal structure; dermis; echinococcosis; liver; nanocrystals; oral administration; pharmacokinetics; solubility; stabilizers; strength (mechanics); swine; zoonoses
Abstract:
... Cystic echinococcosis (CE) is a zoonosis caused by Echinococcus spp., affecting both humans and animals’ lives. Current treatment of CE by oral administration of albendazole (ABZ) is hampered by several limitations. The poor aqueous solubility and the rapid metabolism of ABZ in the liver are the main issues, leading to lack of efficacy of the treatment. In the present study, we developed a nanocry ...
DOI:
10.1021/acsami.1c11179

59. Albendazole and praziquantel for the control of Neoechinorhynchus buttnerae in tambaqui (Colossoma macropomum)

Author:
Caio Francisco Santana Farias; Franmir Rodrigues Brandão; Fernanda de Alexandre Sebastião; Damy Caroline de Melo Souza; Patrícia Castro Monteiro; Cláudia Majolo; Edsandra Campos Chagas
Source:
Aquaculture international 2021 v.29 no.4 pp. 1495-1505
ISSN:
0967-6120
Subject:
Colossoma macropomum; Neoechinorhynchus; albendazole; commercialization; diet; experimental design; fish; indigenous species; palatability; praziquantel; toxicity; Brazil
Abstract:
... The increase in the production and commercialization of aquatic organisms in Brazil is partly due to the growth of native species such as tambaqui. The intensification of fish farming systems has led to an increased occurrence of parasitic diseases, and this has become a serious issue, especially in fish farms in northern Brazil. The present study evaluated the use of albendazole and praziquantel ...
DOI:
10.1007/s10499-021-00687-5

60. Alterations in Taenia crassiceps cysticerci cytoskeleton induced by nitazoxanide and flubendazole

Author:
Nayana Ferreira de Lima; Guaraciara de Andrade Picanço; Diana Gabriela Ríos Valencia; Edgar Oliver López Villegas; María Del Rosário Espinoza Mellado; Javier R. Ambrosio; Marina Clare Vinaud
Source:
Acta tropica 2021 v.221 pp. 106027
ISSN:
0001-706X
Subject:
Taenia crassiceps; Taenia solium; Western blotting; actin; albendazole; central nervous system; cysticerci; cysticercosis; cytoskeleton; electrophoresis; eyes; flubendazole; larvae; models; parasites; praziquantel; transmission electron microscopy; tubulin
Abstract:
... Cysticercosis is the presence of Taenia solium larval stage in tissues such as central nervous system, skin, muscles and eye globe. The current treatment is based on albendazole and praziquantel which already present resistance reports. Therefore, the search for alternative treatments is paramount. The aim of this study was to determine the effect of flubendazole and nitazoxanide on cytoskeleton p ...
DOI:
10.1016/j.actatropica.2021.106027

61. Alveolar Echinococcosis of the Parotid Gland—An Ultra Rare Location Reported from Western Europe

Author:
Tim Koppen; Thomas F. E. Barth; Klaus W. Eichhorn; Jennis Gabrielpillai; Ralph Kader; Friedrich Bootz; Thorsten Send
Source:
Pathogens 2021 v.10 no.4 pp. -
ISSN:
2076-0817
Subject:
Echinococcus multilocularis; adjuvants; albendazole; echinococcosis; histology; larvae; liver; males; nerve tissue; parotid gland; patients; resection; zoonoses; Central Asia; Central European region; China; Europe; Western European region
Abstract:
... (1) Background: Alveolar echinococcosis (AE) is restricted to the northern hemisphere with high endemic regions in Central Europe, North and Central Asia as well as Western China. The larval stage of Echinococcus multilocularis (E. multilocularis) causes AE with tumor-like growth. Humans are accidental hosts. This report is on the first case of AE becoming clinically manifested in the parotic glan ...
DOI:
10.3390/pathogens10040426

62. Amphimas pterocarpoides harms.: An Evaluation of flavonoid and phenolic contents, wound healing, anthelmintic and antioxidant activities of the leaves and stem bark

Author:
Evelyn Asante-Kwatia; Silas Adjei; Yakubu Jibira; Lord Gyimah; George Adjei-Hinneh; Isaac Kingsley Amponsah; Abraham Yeboah Mensah
Source:
Heliyon 2021 v.7 no.11 pp. e08261
ISSN:
2405-8440
Subject:
Pheretima; adults; albendazole; aluminum chloride; antioxidant activity; bark; colorimetry; coumarins; death; ethyl acetate; excision; free radicals; gallic acid; leaves; methanol; models; mortality; paralysis; petroleum; phytosterols; quality control; quercetin; saponins; silver; sulfadiazine; topical application; traditional medicine; triterpenoids
Abstract:
... The present study evaluated the wound healing, anthelmintic and antioxidant potentials of crude methanol extracts and fractions (petroleum ether, ethyl acetate and methanol) of the leaves and stem bark of Amphimas pterocarpoides. Wound healing activity was determined by the dermal excision model in rats; anthelmintic activity was evaluated by the adult worm motility test using the adult Indian wor ...
DOI:
10.1016/j.heliyon.2021.e08261

63. Anthelmintic activity of pomegranate peel extract (Punica granatum) and synthetic anthelmintics against gastrointestinal nematodes in cattle, sheep, goats, and buffalos: in vivo study

Author:
Ahmed M. Kaiaty; Fayez A. Salib; Sohila M. El-Gameel; Ahmed M. Hussien; Mohamed S. Kamel
Source:
Parasitology research 2021 v.120 no.11 pp. 3883-3893
ISSN:
0932-0113
Subject:
Punica granatum; albendazole; animal fertility; cattle; death; fecal egg count; gastroenteritis; gastrointestinal nematodes; ivermectin; meat; milk; parasitology; plant extracts; pomegranates; research; sheep; wool production
Abstract:
... Parasitic gastroenteritis (PGE) is one of the most important parasitic diseases that causes economic losses and health problems in ruminants. PGE causes a drop in milk, meat, and wool production in addition to decreasing animal fertility and sometimes leading to animal death. Conventional anthelmintics used for animal treatment are expensive, especially for farmers in developing countries. Moreove ...
DOI:
10.1007/s00436-021-07311-8

64. Anthelmintic resistance in commercial sheep farms in Costa Rica

Author:
I.C. Castro-Arnáez; V.M. Montenegro; B. Vargas-Leitón; V. Álvarez-Calderón; N. Soto-Barrientos
Source:
Veterinary Parasitology: Regional Studies and Reports 2021 v.23 pp. 100506
ISSN:
2405-9390
Subject:
Chabertia; Cooperia; Haemonchus; Oesophagostomum; Teladorsagia; Trichostrongylus; albendazole; eggs; farms; fecal egg count; ivermectin; larvae; levamisole; parasites; sheep; veterinary parasitology; Costa Rica
Abstract:
... Forty-eight commercial sheep farms were sampled between the years 2017 and 2019 to evaluate the percentage of reduction of the three families of broad-spectrum anthelmintic drugs available in Costa Rica - benzimidazoles (albendazole), macrocyclic lactones (ivermectin) and imidazothiazoles (levamisole) - in grazing animals by using the fecal egg count reduction test. Animals were selected based on ...
DOI:
10.1016/j.vprsr.2020.100506

65. Anthelmintic resistance of gastrointestinal nematodes in sheep grazing in irrigated and dry areas in the semiarid region of northeastern Brazil

Author:
Lauricia S. Nascimento; Anna M. C. F. Evaristo; Glauber M. B. Oliveira; Matheus S. Ferreira; Déborah L. R. Silva; Sergio S. Azevedo; Sandra M. Yamamoto; Márcia M. Araújo; Mauricio C. Horta
Source:
Tropical animal health and production 2021 v.53 no.2 pp. 267
ISSN:
0049-4747
Subject:
Haemonchus contortus; adults; albendazole; closantel; deworming; fecal egg count; feces; flocks; gastrointestinal nematodes; irrigated farming; irrigation; ivermectin; levamisole; moxidectin; semiarid zones; sheep; Brazil
Abstract:
... This study aimed to determine the AR of gastrointestinal nematodes (GIN) to commercial drugs in sheep flocks naturally infected, grazing in irrigated (IA) and dry (DA) areas of the semiarid region in northeastern Brazil. Fecal egg count reduction tests (FECRT) were performed at 10 farms. From each flock, 36 adult sheep were selected and divided into five groups (G1 (0.08% ivermectin), G2 (10% albe ...
DOI:
10.1007/s11250-021-02647-w

66. Anti-echinococcal effect of verapamil involving the regulation of the calcium/calmodulin-dependent protein kinase II response in vitro and in a murine infection model

Author:
Hai-Jun Gao; Xu-Dong Sun; Yan-Ping Luo; Hua-Sheng Pang; Xing-Ming Ma; Ting Zhang; Tao Jing; Wei Hu; Yu-Juan Shen; Jian-Ping Cao
Source:
Parasites & vectors 2021 v.14 no.1 pp. 108
ISSN:
1756-3305
Subject:
Echinococcus granulosus; Echinococcus multilocularis; albendazole; alizarin; atomic absorption spectrometry; blood serum; calcium; calcium-calmodulin-dependent protein kinase; drug therapy; echinococcosis; gene expression; immunohistochemistry; liver; mice; models; parasites; protoscoleces; quantitative polymerase chain reaction; ultrastructure; verapamil; zoonoses
Abstract:
... BACKGROUND: Echinococcosis, which is caused by the larvae of cestodes of the genus Echinococcus, is a parasitic zoonosis that poses a serious threat to the health of humans and animals globally. Albendazole is the drug of choice for the treatment of echinococcosis, but it is difficult to meet clinical goals with this chemotherapy due to its low cure rate and associated side effects after its long- ...
DOI:
10.1186/s13071-021-04618-4

67. Anti-pinworm activity of novel coumarin-based trisubstituted methanes in Syphacia obvelata-infected mice

Author:
Errini Decruse Dhar; Arun K. Yadav; Grace Basumatary; Ghanashyam Bez
Source:
Parasitology international 2021 v.85 pp. 102425
ISSN:
1383-5769
Subject:
Syphacia; acute toxicity; albendazole; body weight; parasitology; risk
Abstract:
... The control of pinworms mainly relies on use of anthelmintic drugs. At present, there exists only few medications against pinworms, and their repeated use pose a serious risk of resistance development. Therefore, new anti-pinworm drugs are required to overcome the risk of resistance. This study reports the anti-pinworm activity of three novel coumarin-based trisubstituted methanes (TRSMs), i.e., 6 ...
DOI:
10.1016/j.parint.2021.102425

68. Anti-trypanosomal and anthelminthic properties of ethanol and aqueous extracts of Tetrapleura tetraptera Taub

Author:
Ahmed Wahab Obeng; Yaw Duah Boakye; Theresa Appiah Agana; Georgina Isabella Djameh; Daniel Boamah; Francis Adu
Source:
Veterinary parasitology 2021 v.294 pp. 109449
ISSN:
0304-4017
Subject:
Pheretima; Tetrapleura tetraptera; adults; albendazole; antitrypanosomal properties; death; dose response; ethanol; flavonoids; fruits; gas chromatography-mass spectrometry; paralysis; parasites; public health; saponins; triterpenoids; trypanosomiasis; veterinary parasitology; Africa
Abstract:
... Trypanosomosis and helminthosis, considered as part of neglected tropical diseases, are parasitic infections of public health importance, especially in Africa. Medicinal plants have been used in most parts of Africa, to treat these parasitic infections. The study aims to determine the anti-trypanosomal and anthelminthic properties of Tetrapleura tetraptera (fruit and stembark). The aqueous extract ...
DOI:
10.1016/j.vetpar.2021.109449

69. Assessing the Efficacy of Albendazole against Fasciola hepatica in Naturally Infected Cattle by In Vivo and In Vitro Methods

Author:
Michal Babják; Alžbeta Königová; Ľudmila Burcáková; Michaela Komáromyová; Michaela Urda Dolinská; Marián Várady
Source:
Veterinary sciences 2021 v.8 no.11 pp. -
ISSN:
2306-7381
Subject:
Charolais; Fasciola hepatica; albendazole; autumn; body weight; diagnostic techniques; eggs; farms; fascioliasis; fecal egg count; ovicides
Abstract:
... This study was performed on a cattle farm with a long-term use of albendazole (ABZ) and a permanent history of fasciolosis for comparing in vivo and in vitro methods for the detection of anthelmintic resistance and drug efficacy. A selected group of 10 Charolais cows was treated in autumn 2020 with ABZ at a dose of 7.5 mg/kg body weight. Another group of 10 cows remained untreated as a control. Th ...
DOI:
10.3390/vetsci8110249

70. Bioaugmentation of animal feces as a mean to mitigate environmental contamination with anthelmintic benzimidazoles

Author:
S. Lagos; C. Perruchon; A. Tsikriki; E. Gourombinos; S. Vasileiadis; S. Sotiraki; D.G. Karpouzas
Source:
Journal of hazardous materials 2021 v.419 pp. 126439
ISSN:
0304-3894
Subject:
albendazole; benzimidazole; bioaugmentation; environmental exposure; excretion; feces; fenbendazole; flubendazole; fumigation; gastrointestinal nematodes; liquids; mebendazole; metabolism; microbial communities; pollution; sheep; thiabendazole
Abstract:
... Anthelmintics are used to control infestations of ruminants by gastrointestinal nematodes. The limited metabolism of anthelmintics in animals result in their excretion in feces. These could be piled up in the floor of livestock farms, constituting a point source of environmental contamination, or used as manures in agricultural soils where they persist or move to water bodies. Hence the removal of ...
DOI:
10.1016/j.jhazmat.2021.126439

71. Biomediated synthesis, characterization, and biological applications of nickel oxide nanoparticles derived from Toona ciliata, Ficus carica and Pinus roxburghii

Author:
Azar Ullah Mirza; Mohd Shoeb Khan; Abdul Kareem; Shahab A. A. Nami; Shahnawaz Ahmad Bhat; Abdulrahman Mohammad; Paramjit Singh; Nahid Nishat
Source:
Bioprocess and biosystems engineering 2021 v.44 no.7 pp. 1461-1476
ISSN:
1615-7591
Subject:
Ficus carica; Fourier transform infrared spectroscopy; Gram-negative bacteria; Pheretima; Pinus roxburghii; Toona ciliata; X-ray diffraction; agar; albendazole; antibacterial properties; bioprocessing; ciprofloxacin; energy-dispersive X-ray analysis; fluorescence emission spectroscopy; gentamicin; nickel; nickel oxide; oxygen; photoluminescence; reflectance spectroscopy; thermogravimetry; transmission electron microscopy
Abstract:
... Biomediated ecofriendly method for the synthesis of nickel oxide nanoparticles using plants extracts (Toona ciliata, Ficus carica and Pinus roxburghii) has been reported. The nanoparticles so obtained were characterized by various techniques such as ultraviolet–visible, powder X-ray diffraction, Fourier transform infrared spectroscopy, attenuated total reflectance spectroscopy, scanning electron m ...
DOI:
10.1007/s00449-021-02528-4

72. Capsicum frutescens and Citrus limon: a new take on therapy against experimental trichinellosis

Author:
Marwa Ahmed Mohamed Salama; Nahed E. Mostafa; Naglaa Fathy Abd El-Aal; Eman M. Mostafa; Samar Kamel Hammad; Rasha Adel; Howayda Said Fouad Moawad
Source:
Journal of helminthology v.95 pp. e26
ISSN:
1475-2697
Subject:
Capsicum frutescens; Citrus limon; absorption; adults; albendazole; albino; blood serum; death; histopathology; human health; larvae; males; mice; necrosis; neoplasms; prednisolone; small intestine; therapeutics; transmission electron microscopy; trichinosis; zoonoses
Abstract:
... Trichinellosis is a zoonotic disease that endangers human health and can lead to death. Restricted absorption and poor results of conventional therapies demand new effective natural remedies to treat both enteral and parenteral trichinellosis. This study assessed the antiparasitic and anti-inflammatory effects of Citrus limon and Capsicum frutescens on murine trichinellosis and compared them with ...
DOI:
10.1017/S0022149X21000171

73. Characterizing dynamic changes of plasma cell-free Echinococcus granulosus DNA before and after cystic echinococcosis treatment initiation

Author:
Yanping Zhao; Quzhen Gongsang; Jingkai Ji; Junhua Li; Fahai Qi; Jiandong Li; Gezhen Qiangba; Wangmu Danzeng; Fang Chen; Hongcheng Zhou; Huasang; Jiefang Yin; Na Pei; Jiandan Xie; Huimin Cai; Asan; Huasheng Pang; Jingzhong Li; Weijun Chen; Bin Li
Source:
Genomics 2021 v.113 no.2 pp. 576-582
ISSN:
0888-7543
Subject:
DNA; Echinococcus granulosus; albendazole; echinococcosis; genomics; ultrasonics
Abstract:
... Over one million people are living with cystic echinococcosis (CE) and alveolar echinococcosis (AE). For CE, long-term albendazole treatment is often needed, which requires regular follow-up. Follow-up is mainly through imaging which is insensitive to subtle changes and subjective to experience. We investigated the changes of Echinococcus granulosus (Eg) cell-free DNA (cfDNA) in plasma of CE patie ...
DOI:
10.1016/j.ygeno.2020.12.035

74. Chemical characterization and in vitro anthelmintic activity of Citrus bergamia Risso and Citrus X paradisii Macfad essential oil against Haemonchus contortus Kirby isolate

Author:
Vivien Patricia Garbin; Beatriz Munguía; Jenny Carolina Saldaña; Cícero Deschamps; Roger Raupp Cipriano; Marcelo Beltrão Molento
Source:
Acta tropica 2021 v.217 pp. 105869
ISSN:
0001-706X
Subject:
Citrus bergamia; Haemonchus contortus; abomasum; adults; albendazole; citrus peels; eggs; equipment; essential oils; food composition; hematophagous parasites; larvae; limonene; nematode control; secondary metabolites
Abstract:
... Haemonchus contortus, a blood-sucking parasite of small ruminants, produces very important economic losses in the productive sector. This abomasum parasite has become resistant to most commercial drugs worldwide, and alternatives to fight this problem are urgently needed. Essential oils (EO) are a complex mixture of volatile secondary metabolites, composed mainly by terpenoids and phenolic compoun ...
DOI:
10.1016/j.actatropica.2021.105869

75. Clinical tolerance and efficacy of anti-parasitic treatment with albendazole in patients with alveolar echinococcosis: long-term follow-up observation in 117 patients

Author:
Valerij D. Zavoikin; Olga P. Zelya; Nelli I. Tumolskaya
Source:
Parasitology research 2021 v.120 no.10 pp. 3603-3610
ISSN:
0932-0113
Subject:
albendazole; blood serum; echinococcosis; liver; neoplasms; parasitology; research; resection; transaminases
Abstract:
... Alveolar echinococcosis is the most severe worm disease primarily detected in the liver. This study aimed to determine the clinical tolerance and efficacy of albendazole in patients with alveolar echinococcosis, depending on the volume of previous surgical treatment or its absence and the duration of anti-parasitic therapy. We retrospectively (over the last 15 years) analyzed the data of 117 patie ...
DOI:
10.1007/s00436-021-07297-3

76. Combination of synthetic anthelmintics and monoterpenes: Assessment of efficacy, and ultrastructural and biophysical properties of Haemonchus contortus using atomic force microscopy

Author:
Carolina R. Silva; Adrian L. Lifschitz; Sara R.D. Macedo; Nagilla R.C.L. Campos; Malaquias Viana-Filho; Ana C.S. Alcântara; Josiel G. Araújo; Luciana M.R. Alencar; Livio M. Costa- Junior
Source:
Veterinary parasitology 2021 v.290 pp. 109345
ISSN:
0304-4017
Subject:
Fourier transform infrared spectroscopy; Haemonchus contortus; albendazole; atomic force microscopy; carvacrol; carvone; citral; eggs; larvae; levamisole; p-cymene; parasites; roughness; synergism; thymol; ultrastructure; veterinary parasitology
Abstract:
... The resistance of Haemonchus contortus to synthetic anthelmintics is of increasing concern; and different strategies are being evaluated to improve parasite control. The present study investigated the in vitro effects of combinations of synthetic compounds and monoterpenes. Additionally, the chemical association of the best combinations and their impact on the ultrastructural and biophysical prope ...
DOI:
10.1016/j.vetpar.2021.109345

77. Computational screening of potential inhibitors targeting MurF of Brugia malayi Wolbachia through multi-scale molecular docking, molecular dynamics and MM-GBSA analysis

Author:
Saritha Poopandi; Rajamanikandan Sundaraj; Raji Rajmichael; Sindhu Thangaraj; Prabhu Dhamodharan; Jayashree Biswal; Veerapandiyan Malaisamy; Chitra Jeyaraj Pandian; Jeyakanthan Jeyaraman
Source:
Molecular and biochemical parasitology 2021 v.246 pp. 111427
ISSN:
0166-6851
Subject:
Bancroftian filariasis; Brugia malayi; Gibbs free energy; Wolbachia; Wuchereria bancrofti; absorption; albendazole; biosynthesis; density functional theory; diethylcarbamazine; endosymbionts; excretion; ivermectin; ligases; mechanics; molecular dynamics; nematicides; parasitology; peptidoglycans; pharmacokinetics; surface area; therapeutics; toxicity; zinc
Abstract:
... Lymphatic filariasis is a parasitic disease caused by the worms Wuchereria bancrofti, Brugia malayi and Brugia timori. Three anti-filarial drugs namely Diethylcarbamazine, Ivermectin and Albendazole and their combinations are used as the control strategies for filariasis. The disease has received much attention in drug discovery due to the unavailability of vaccines and the toxic pharmaceutical pr ...
DOI:
10.1016/j.molbiopara.2021.111427

78. Control of Strongyles in First-Season Grazing Ewe Lambs by Integrating Deworming and Thrice-Weekly Administration of Parasiticidal Fungal Spores

Author:
Mathilde Voinot; Rodrigo Bonilla; Sérgio Sousa; Jaime Sanchís; Miguel Canhão-Dias; José Romero Delgado; João Lozano; Rita Sánchez-Andrade; María Sol Arias; Luís Madeira de Carvalho
Source:
Pathogens 2021 v.10 no.10 pp. -
ISSN:
2076-0817
Subject:
Mucor circinelloides; Strongylidae; albendazole; biological control; chlamydospores; deworming; eggs; erythrocytes; ewes; experimental design; feces; fungi; gastrointestinal system; health status; ivermectin; oral administration
Abstract:
... Parasiticidal fungi have been used in several in vivo experiments in livestock farms worldwide, constituting an effective tool for the biocontrol of gastrointestinal parasites in grazing animals. In the first year of study, two groups of eight first-season pasturing ewe lambs infected by strongyles were dewormed with albendazole, and then, the test group received an oral dose of 10⁶ chlamydospores ...
DOI:
10.3390/pathogens10101338

79. Cysticidal effect of a pure naphthoquinone on Taenia crassiceps cysticerci

Author:
Yuli Aranda-López; Lluvia López-López; Karen Elizabeth Nava Castro; María Dolores Ponce-Regalado; Luis Enrique Becerril-Villanueva; Manuel Iván Girón-Pérez; Víctor Hugo Del Río-Araiza; Jorge Morales-Montor
Source:
Parasitology research 2021 v.120 no.11 pp. 3783-3794
ISSN:
0932-0113
Subject:
Taenia crassiceps; Taenia solium; albendazole; bioavailability; cysticerci; helminths; mice; models; naphthoquinones; neurocysticercosis; paralysis; parasitology; reproduction; research; therapeutics
Abstract:
... Cysticercosis is a disease caused by the metacestode of the parasite Taenia solium (T. solium). In humans, the most severe complication of the disease is neurocysticercosis. The drug of choice to treat this disease is albendazole; however, the bioavailability and efficacy of the drug are variable. Therefore, new molecules with therapeutic effects against this and other parasitic infections caused ...
DOI:
10.1007/s00436-021-07281-x

80. Degradation of benzimidazoles by photoperoxidation: metabolites detection and ecotoxicity assessment using Raphidocelis subcapitata microalgae and Vibrio fischeri

Author:
Wilson Augusto Lima Venancio; Caio Rodrigues-Silva; Mylena Spina; Vinicius Diniz; José Roberto Guimarães
Source:
Environmental science and pollution research 2021 v.28 no.19 pp. 23742-23752
ISSN:
0944-1344
Subject:
Selenastrum capricornutum; Vibrio fischeri; albendazole; ecotoxicology; fenbendazole; humans; metabolites; microalgae; oxfendazole; pollution; research; thiabendazole; toxicity; veterinary medicine
Abstract:
... Benzimidazoles (BZ) are among the most used drugs to treat parasitic diseases in both human and veterinary medicine. In this study, solutions fortified with albendazole (ABZ), fenbendazole (FBZ), and thiabendazole (TBZ) were subjected to photoperoxidation (UV/H₂O₂). The hydroxyl radicals generated by the process removed up to 99% of ABZ, and FBZ, in the highest dosage of H₂O₂ (i.e., 1.125 mmol L⁻¹ ...
DOI:
10.1007/s11356-020-11294-x

81. Depletion study and estimation of the withdrawal period for albendazole in tambaqui (Colossoma macropomum) parasitised by acanthocephalan (Neoechinorhynchus buttnerae) treated with albendazole-containing feed

Author:
Rafaelle Pereira Cordeiro; Patrícia Aparecida de Campos Braga; Maria Juliete Souza Rocha; Edsandra Campos Chagas; Felix Guillermo Reyes Reyes
Source:
Food additives & contaminants 2021 v.38 no.11 pp. 1883-1896
ISSN:
1944-0057
Subject:
Codex Alimentarius; Colossoma macropomum; Neoechinorhynchus; albendazole; body weight; fish; liquid chromatography; maximum residue limits; medicated feeds; metabolites; muscles; sulfoxides; tandem mass spectrometry
Abstract:
... This study provides the first data related to albendazole (ABZ) and its main metabolites [albendazole sulphoxide (ABZSO), albendazole sulphone (ABZSO₂), and albendazole-2-amino sulphone (ABZ-2-NH₂-SO₂)] residue depletion in tambaqui (Colossoma macropomum) parasitised by acanthocephalan (Neoechinorhynchus buttnerae). The ABZ withdrawal period was also calculated. The fish received a daily dose of 1 ...
DOI:
10.1080/19440049.2021.1954700

82. Determination of albendazole and ivermectin residues in cattle and poultry-derived samples from India by micellar liquid chromatography

Author:
Rajendra-Prasad Pawar; Abhilasha Durgbanshi; Devasish Bose; Juan Peris-Vicente; Jaume Albiol-Chiva; Josep Esteve-Romero; Samuel Carda-Broch
Source:
Journal of food composition and analysis 2021 v.103 pp. 104111
ISSN:
0889-1575
Subject:
absorbance; albendazole; calibration; cattle; chemical species; food composition; ivermectin; liquid chromatography; mass spectrometry; pH; pentanols; phosphates; poultry; risk; sodium dodecyl sulfate; wastes; India
Abstract:
... We have developed a method, based on micellar liquid chromatography, to determine albendazole and ivermectin in dairy products and biological waste from bovine, as well as edible tissues from poultry. Anthelmitics were resolved in less than 10 min using a C18 column and a mobile phase of 0.15 mol/L sodium dodecyl sulfate – 6% 1-pentanol at buffered at pH 7 with a 0.01 M phosphate salt, running und ...
DOI:
10.1016/j.jfca.2021.104111

83. Development of an enzyme-linked immunosorbent assay for the detection of mebendazole in chicken and mutton

Author:
Jinxin He; Yan Zheng; Xiaorong Chen; Na Li; Fang Tang; Nairui Huo; Jianzhong Wang; Shaopeng Gu
Source:
Analytical methods 2021 v.13 no.14 pp. 1740-1746
ISSN:
1759-9679
Subject:
albendazole; benzimidazole; chickens; cross reaction; detection limit; enzyme-linked immunosorbent assay; fenbendazole; flubendazole; haptens; helminthiasis; high performance liquid chromatography; intestines; mebendazole; muscles; mutton; oxfendazole; propionic acid; rabbits; New Zealand
Abstract:
... Mebendazole (MBZ), a synthetic benzimidazole, is most widely used for the treatment of intestinal helminthiasis. In the present study, a hapten mimicking the MBZ structure was designed by introducing propanoic acid and coupling to carrier proteins by the active ester method to immunize New Zealand rabbits. A sensitive enzyme-linked immunosorbent assay (ELISA) was developed for the analysis of MBZ ...
DOI:
10.1039/d1ay00133g

84. Effect of antihelminths with contrasting efficacy against gastrointestinal nematodes on the live-weight gain of young Nellore cattle

Author:
José Henrique das Neves; Nadino Carvalho; Nayara Capaldi dos Santos; João Ratti Júnior; Cyntia L. Martins; Alessandro F.T. Amarante
Source:
Veterinary Parasitology: Regional Studies and Reports 2021 v.25 pp. 100597
ISSN:
2405-9390
Subject:
Brachiaria; Cooperia; Haemonchus placei; Nellore; Trichostrongylus; Urochloa; additive effect; albendazole; anemia; blood; body weight changes; calves; eggs; females; gastroenteritis; gastrointestinal nematodes; ivermectin; liveweight gain; males; parasitism; sulfoxides; veterinary parasitology; weight gain
Abstract:
... We estimated the losses caused by gastrointestinal nematode (GIN) infections in young Nellore cattle born in three consecutive calving seasons (Cycles I, II and III). Three groups of animals: Group 1 - free from GIN using 2.5 mg/kg of albendazole sulfoxide; Group II - free from Oesophagosomum radiatum using 0.2 mg/kg of ivermectin but infected with ivermectin-resistant Haemonchus placei and Cooper ...
DOI:
10.1016/j.vprsr.2021.100597

85. Effect of mast cell stabilization on angiogenesis in primary and secondary experimental Trichinella spiralis infection

Author:
Marwa A. EL-Dardiry; Amany A. Abdel-Aal; Magda S. A. Abdeltawab; Mona El-Sherbini; Marwa A. Hassan; Asmaa A. Abdel-Aal; Manal Badawi; Shady E. Anis; Bahaa-Eldin A. Khaled; Abeer S. Al-Antably
Source:
Parasites & vectors 2021 v.14 no.1 pp. 567
ISSN:
1756-3305
Subject:
Trichinella spiralis; adults; albendazole; angiogenesis; encystment; females; histopathology; immunohistochemistry; inflammation; larvae; mast cells; medicine; muscle tissues; muscles; parasite load; parasites; small intestine; stabilizers; trichinosis; vaccination; vascular endothelial growth factors
Abstract:
... BACKGROUND: Mast cells are known to affect the primary and secondary immune responses against parasites, and this effect is partially mediated through the release of pro-angiogenic mediators. The aim of this study was to explore the effect of the mast cell stabilizer (MCS), ketotifen, with and without albendazole, an anti-parasitic prescription medicine, on the inflammatory response against Trichi ...
DOI:
10.1186/s13071-021-05075-9

86. Effect of sex and genotype of the host on the anthelmintic efficacy of albendazole microcrystals, in the CBi-IGE Trichinella infection murine model

Author:
Ana V. Codina; Josefina Priotti; Darío Leonardi; María D. Vasconi; María C. Lamas; Lucila I. Hinrichsen
Source:
Parasitology 2021 v.148 no.13 pp. 1545-1553
ISSN:
1469-8161
Subject:
Trichinella spiralis; albendazole; animal models; bioavailability; biopharmaceuticals; cellulose; chitosan; fecundity; females; genotype; larvae; migratory behavior; muscles; parasites; parasitology; trichinosis; water solubility
Abstract:
... Albendazole (ABZ) is an anthelmintic pharmaceutical commonly used in the treatment of nematode infections. It is a Class II drug poorly water-soluble, with very low bioavailability, a feature particularly limiting to treat the trichinellosis chronic phase. Microcrystals obtained by controlled precipitation using hydroxyethyl cellulose and chitosan have previously been shown to improve ABZ biopharm ...
DOI:
10.1017/S0031182021001128

87. The Effect of the Manure from Sheep Treated with Anthelmintics on Clover (Trifolium pratense)

Author:
Lenka Langhansová; Martina Navrátilová; Lenka Skálová; Kateřina Moťková; Radka Podlipná
Source:
Agronomy 2021 v.11 no.9 pp. -
ISSN:
2073-4395
Subject:
Trifolium pratense; agronomy; albendazole; food chain; ivermectin; lipid peroxidation; metabolism; metabolites; proline; sheep; soil
Abstract:
... The anthelmintics (regularly administered to livestock to control the infections caused by parasitic worms) and their metabolites formed in treated animals are excreted to the environment. This contamination might have a negative influence on non-target organisms including plants. Our previous studies described the uptake, metabolism, and effects of anthelmintics in plants using in vitro models ex ...
DOI:
10.3390/agronomy11091892

88. Effects of Allium sativum on IFN-γ and IL4 concentrations in mice with cystic echinococcosis

Author:
Z. Shirgholami; H. Borji; H. Mohebalian; M. Heidarpour
Source:
Experimental parasitology 2021 v.220 pp. 108042
ISSN:
0014-4894
Subject:
Allium sativum; Echinococcus granulosus; albendazole; blood serum; echinococcosis; females; interleukin-4; parasitology; protoscoleces
Abstract:
... The aim of the current investigation was to assess the impacts of methanolic extract of Allium sativum (MEAS) on IL-4 (a cytokine derived from Th2 cells) and IFN-ɣ (a cytokine derived from Th1 cells) levels in mice infected with Echinococcus granulosus. Sixty healthy BALB/c female mice were used in this study. Each animal was intraperitoneally injected with 1500 protoscoleces. The infected animals ...
DOI:
10.1016/j.exppara.2020.108042

89. The Effects of Nitric Oxide and Inhibitor, and Combination of Albendazole and Praziquantel On Liver in Mice Injected with Echinococcus granulosus Larvae

Author:
Asli Kandil; Aysen Gargili Keles; Huriye Balci; Cihan Demirci Tansel
Source:
Acta tropica 2021 v.219 pp. 105917
ISSN:
0001-706X
Subject:
Echinococcus granulosus; albendazole; albino; blood serum; echinococcosis; electron microscopy; endoplasmic reticulum; endothelial nitric oxide synthase; eosinophils; hepatocytes; histopathology; immunohistochemistry; inducible nitric oxide synthase; inflammation; intraperitoneal injection; larvae; light microscopy; liver; malondialdehyde; nitrates; nitric oxide; nitrites; nitroprusside; nuclear membrane; pathogenesis; praziquantel; protoscoleces; sheep
Abstract:
... In this study, the role of nitric oxide (NO) in the pathogenesis of hydatidosis and the interaction with effects of anthelmintic drugs, albendazole and praziquantel, were examined in larval infection caused by protoscolices obtained from hydatid cysts of sheep liver in Albino Balb/c mice.Animals were divided into ten groups including controls and infected groups. Larval infection was established w ...
DOI:
10.1016/j.actatropica.2021.105917

90. Efficacy of triclabendazole and albendazole against Fasciola spp. infection in cattle in Côte d'Ivoire: a randomised blinded trial

Author:
Jules N. Kouadio; Jennifer Giovanoli Evack; Louise Y. Achi; Oliver Balmer; Jürg Utzinger; Eliézer K. N'Goran; Bassirou Bonfoh; Jan Hattendorf; Jakob Zinsstag
Source:
Acta tropica 2021 v.222 pp. 106039
ISSN:
0001-706X
Subject:
Fasciola; albendazole; cattle; confidence interval; eggs; fascioliasis; feces; intermediate hosts; livestock husbandry; odds ratio; pastures; randomized clinical trials; snails; triclabendazole; Cote d'Ivoire
Abstract:
... Triclabendazole is the anthelminthic of choice for the treatment of fascioliasis, however, it is only registered in a few countries. We investigated the efficacy of a single-dose of triclabendazole (12 mg/kg) or albendazole (15 mg/kg) against Fasciola spp. infection in cattle on farms in the northern part of Côte d'Ivoire in a randomized clinical trial. Faecal samples were obtained from 196 cattle ...
DOI:
10.1016/j.actatropica.2021.106039

91. Environmental risk assessment of the anthelmintic albendazole in Eastern Africa, based on a systematic review

Author:
Sileshi Belew; Sultan Suleman; Evelien Wynendaele; Luc Duchateau; Bart De Spiegeleer
Source:
Environmental pollution 2021 v.269 pp. 116106
ISSN:
0269-7491
Subject:
Monte Carlo method; albendazole; ecotoxicology; environmental assessment; medicine; metabolites; pollution; relative risk; soil; surface water; systematic review; toxicity; uncertainty; Eastern Africa
Abstract:
... This study performs an environmental risk assessment (ERA) of the anthelmintic medicine albendazole (ABZ) in the eastern African region. A systematic literature search strategy was applied to obtain quantitative information on the physicochemical characteristics, the metabolization-fate, the ecotoxicity and the environmental occurrence in different countries worldwide serving as model regions. In ...
DOI:
10.1016/j.envpol.2020.116106

92. The Epidemiology, Clinical Manifestations, Radiology, Microbiology, Treatment, and Prognosis of Echinococcosis: Results of NENEHATUN Study

Author:
Emine Parlak; Ferhan Kerget; Tuna Demirdal; Pınar Şen; Ali Bilal Ulaş; Şenay Öztürk Durmaz; Umut Pekok; Ayşe Ertürk; Deniz Akyol; Esma Kepenek Kurt; Handan Köksal Alay; Hüsnü Pullukçu; Meltem Taşbakan; Serpil Erol; Esra Laloğlu; Derya Öztürk Engin; Canan Ağalar; Mehmet Parlak
Source:
Vector borne and zoonotic diseases 2021 v.21 no.12 pp. 948-954
ISSN:
1557-7759
Subject:
Echinococcus granulosus; albendazole; cough; echinococcosis; education; enzyme-linked immunosorbent assay; epidemiology; hemagglutination tests; microbiology; mortality; pain; politics; prognosis; public health; radiology; zoonoses
Abstract:
... Aim: Echinococcosis, caused by Echinococcus species, is an important zoonotic disease causing major health problems in humans and animals. Herein, we aimed to evaluate the epidemiology, clinical and laboratory parameters, radiological, serological, pathological, and treatment protocols of followed-up cases of hydatidosis. Methods: A total of 550 patients diagnosed with hydatid cyst disease were in ...
DOI:
10.1089/vbz.2021.0029

93. Essential oil of Rosmarinus officinalis induces in vitro anthelmintic and anticoccidial effects against Haemonchus contortus and Eimeria spp. in small ruminants

Author:
M Aouadi; E Sebai; A Saratsis; V Kantzoura; K Saratsi; K Msaada; S Sotiraki; H Akkari
Source:
Veterinární medicína v.66 no.4 pp. 146-155
ISSN:
0375-8427
Subject:
Eimeria; Haemonchus contortus; Rosmarinus officinalis; adults; albendazole; camphor; chemical composition; cineole; coccidiostats; eggs; essential oils; medicinal plants; oils; oocysts; oocytes; rosemary; sheep; sporulation; Tunisia
Abstract:
... This work aimed to evaluate the valorisation of the volatile oil of “Rosmarinus officinalis L.”, a spontaneously growing medicinal plant in Tunisia, by studying its chemical composition, anthelmintic and anticoccidial potentials against Eimeria spp. and Haemonchus contortus at different essential oil concentrations. The main compounds of the R. officinalis essential oil identified by GC/MS were th ...
DOI:
10.17221/139/2020-vetmed

94. Evaluation of Annona muricata (Graviola) leaves activity against experimental trichinellosis: in vitro and in vivo studies

Author:
E.S. El-Wakil; H.F. Abdelmaksoud; T.S. AbouShousha; M.M.I. Ghallab
Source:
Journal of helminthology v.95 pp. e53
ISSN:
1475-2697
Subject:
Annona muricata; Trichinella spiralis; adjuvants; adults; albendazole; drug therapy; histopathology; intestines; larvae; leaf extracts; trichinosis
Abstract:
... Our work aimed to evaluate the possible effect of Annona muricata (Graviola) leaf extract on Trichinella spiralis in in vitro and in vivo studies. Trichinella spiralis worms were isolated from infected mice and transferred to three culture media – group I (with no drugs), group II (contained Graviola) and group III (contained albendazole) – then they were examined using the electron microscope. In ...
DOI:
10.1017/S0022149X21000481

95. Experimental Study of Albendazole Immunotropic Activity in Low Doses

Author:
O. I. Mamykova
Source:
Russian agricultural sciences 2021 v.47 no.1 pp. 88-92
ISSN:
1068-3674
Subject:
albendazole; antigens; delayed hypersensitivity; hemagglutinins; immune response; therapeutics
Abstract:
... Evaluation of the immunotropic effect of albendazole in low therapeutic doses has been carried out based on testing the ability of CBA × C57BL/6 mice lines to induce a delayed-type hypersensitivity (DTH) and the synthesis of antibodies against the thymus-dependent antigen. It has been shown that albendazole at doses of 2.5 and 5.0 mg/kg had no effect on the immune response of the cellular and humo ...
DOI:
10.3103/S1068367421010122

96. First report of multiple drug-resistant gastrointestinal nematodes of sheep in Arbat District, Sulaymaniyah, Iraq detected by in vivo and in vitro methods

Author:
Hiewa Othman Dyary; Hamasalih Qadir Banaz
Source:
Journal of Veterinary Research 2021 v.65 no.3 pp. 293-299
ISSN:
2450-8608
Subject:
Nematodirus; Trichostrongylus; Trichuris; albendazole; eggs; fecal egg count; gastrointestinal nematodes; ivermectin; larval development; levamisole; multiple drug resistance; sheep; therapeutics; veterinary medicine; Iraq
Abstract:
... The control of gastrointestinal nematodes (GINs) in small ruminants is principally dependent on anthelmintic therapy, which encounters the rising problem of anthelmintic resistance (AR) development. Veterinarians reported anthelmintic failure in several sheep farms in Arbat District, Sulaymaniyah, northern Iraq, which called for a systematic study about the efficacy of three commonly used drugs: a ...
DOI:
10.2478/jvetres-2021-0047

97. Frequency of sheep farms with anthelmintic resistant gastrointestinal nematodes in the Mexican Yucatán peninsula

Author:
Jerónimo Sepúlveda-Vázquez; Manuel Jesús Lara-Del Rio; Juan José Vargas-Magaña; Jorge Alfredo Quintal-Franco; Rosendo Alberto Alcaraz-Romero; Melina Maribel Ojeda-Chi; Roger Iván Rodríguez-Vivas; Gabriela Mancilla-Montelongo; Pedro Geraldo González-Pech; Juan Felipe de Jesús Torres-Acosta
Source:
Veterinary Parasitology: Regional Studies and Reports 2021 v.24 pp. 100549
ISSN:
2405-9390
Subject:
albendazole; confidence interval; fecal egg count; feces; gastrointestinal nematodes; ivermectin; levamisole; sulfoxides; surveys; veterinary parasitology; Mexico
Abstract:
... The present study explored the frequency of hair-sheep farms with gastrointestinal nematodes (GIN) resistant to albendazole sulfoxide (AS), ivermectin (IVM) and levamisole (LEV) in the Yucatán peninsula, México, using the faecal egg count reduction test (FECRT), and compared the frequency of farms diagnosed with resistance using three different formulae. The survey included farms from the states o ...
DOI:
10.1016/j.vprsr.2021.100549

98. Guidelines for the diagnosis and treatment of neuroangiostrongyliasis: updated recommendations

Author:
Vernon Ansdell; Kenton J. Kramer; Jourdan K. McMillan; William L. Gosnell; Gerald S. Murphy; B C Meyer; Elizabeth U. Blalock; Johnnie Yates; Louis Lteif; Olivia A. Smith; Marian Melish
Source:
Parasitology 2021 v.148 no.2 pp. 227-233
ISSN:
1469-8161
Subject:
DNA; Hawaii; adrenal cortex hormones; albendazole; central nervous system; complications (disease); lungworms; parasitology; quantitative polymerase chain reaction; rats
Abstract:
... A subcommittee of the Hawaii Governor's Joint Task Force on Rat Lungworm Disease developed preliminary guidelines for the diagnosis and treatment of neuroangiostrongyliasis (NAS) in 2018 (Guidelines, 2018). This paper reviews the main points of those guidelines and provides updates in areas where our understanding of the disease has increased. The diagnosis of NAS is described, including confirmat ...
DOI:
10.1017/S0031182020001262

99. Hapten Synthesis and Monoclonal Antibody Preparation for Simultaneous Detection of Albendazole and Its Metabolites in Animal-Origin Food

Author:
Shibei Shao; Xuping Zhou; Leina Dou; Yuchen Bai; Jiafei Mi; Wenbo Yu; Suxia Zhang; Zhanhui Wang; Kai Wen
Source:
Foods 2021 v.10 no.12 pp. -
ISSN:
2304-8158
Subject:
albendazole; animal-based foods; beef; benzimidazole; chemical species; drug resistance; haptens; hydrophobicity; immune system; immunoassays; industry; liver; metabolites; milk; monoclonal antibodies; toxicity
Abstract:
... Albendazole (ABZ) is one of the benzimidazole anthelmintics, and the overuse of ABZ in breeding industry can lead to drug resistance and a variety of toxic effects in humans. Since the residue markers of ABZ are the sum of ABZ and three metabolites (collectively referred to as ABZs), albendazole-sulfone (ABZSO₂), albendazole-sulfoxide (ABZSO), and albendazole-2-amino-sulfone (ABZNH₂SO₂), an antibo ...
DOI:
10.3390/foods10123106

100. Heterogeneous response of Wuchereria bancrofti–infected persons to diethylcarbamazine (DEC) and its implications for the Global Programme to Eliminate Lymphatic Filariasis (GPELF)

Author:
Thirumal Sankari; Swaminathan Subramanian; Subhash L. Hoti; Subhada P. Pani; Purushothaman Jambulingam; Pradeep K. Das
Source:
Parasitology research 2021 v.120 no.1 pp. 311-319
ISSN:
0932-0113
Subject:
Bancroftian filariasis; Wuchereria; albendazole; body weight; diethylcarbamazine; gender; ivermectin; microfilariae; models; parasites; parasitology; regression analysis; research
Abstract:
... DEC or ivermectin (IVM) in combination with albendazole (ALB) has been the recommended strategy of the Global Programme to Eliminate Lymphatic Filariasis (GPELF) since 2000. Despite effective population coverage (> 65%) with several rounds of MDA with DEC or combination of DEC plus ALB, microfilariae persist in few individuals and they continue to be the source of infection for transmitting LF. We ...
DOI:
10.1007/s00436-020-06950-7