Subject: animal models / Subject term: humans and biotin

Author:: Helm, Ricki M.; Mock, Nell I.; Simpson, Pippa; Mock, Donald M.
Source:: Journal of nutrition 2001 v.131 no.12 pp. 3231-3236
ISSN:: 0022-3166
Subject:: immunocytes; immunoglobulin G; leucine; metabolism; phenotype; humans; immunosuppression; interferon-gamma; spleen; animal models; biotin; rats; cell proliferation; interleukin-4
Abstract:: ... To assess the effects of marginal biotin deficiency on immune function and thereby evaluate immune function as a potential marker for impaired biotin status, we investigated immune function in a rat model during progression from sufficiency to moderate biotin deficiency. As immune function indicators, we assessed the IgG response to a vaccine and the cytokine responses and relative proportions of ...
PubMed:: 11739872

Author:: Katsumi Shibata; Chisa Sugita; Mitsue Sano; Tsutomu Fukuwatari
Source:: Journal of nutritional science 2013 v.2 pp. -
ISSN:: 2048-6790
Subject:: 4-pyridoxic acid; animal models; biotin; blood; blood sampling; excretion; folic acid; food intake; humans; normal values; nutritional status; pantothenic acid; pyridoxal phosphate; pyridoxine; rats; riboflavin; thiamin; urine
Abstract:: ... We have reported previously that the urinary excretion of B-group vitamins reflects recent dietary intakes of these vitamins. We also proposed reference values for the urinary levels of B-group vitamins for human subjects, and used these for evaluating human nutritional status. However, the question arises as to whether the urinary excretion of B-group vitamins in animals or human subjects decreas ...
DOI:: 10.1017/jns.2013.3
PubMed:: 25191560
PubMed Central:: PMC4153309
: https://doi.org/10.1017/jns.2013.3

Author:: Lorena Gallego-Villar; Belén Pérez; Magdalena Ugarte; Lourdes R. Desviat; Eva Richard
Source:: Biochemical and biophysical research communications 2014 v.452 pp. 457-461
ISSN:: 0006-291X
Subject:: acidosis; adjuvants; animal models; antioxidants; biotin; fibroblasts; glutathione peroxidase; humans; mitochondria; movement disorders; patients; propionyl-CoA carboxylase; resveratrol; superoxide dismutase; therapeutics
Abstract:: ... Propionic acidemia (PA), caused by a deficiency of the mitochondrial biotin dependent enzyme propionyl-CoA carboxylase (PCC) is one of the most frequent organic acidurias in humans. Most PA patients present in the neonatal period with metabolic acidosis and hyperammonemia, developing different neurological symptoms, movement disorders and cardiac complications. There is strong evidence indicating ...
DOI:: 10.1016/j.bbrc.2014.08.091
: https://doi.org/10.1016/j.bbrc.2014.08.091

Author:: Laszlo Otvos Jr.; Stefan W. Vetter; Mohit Koladia; Daniel Knappe; Rico Schmidt; Eszter Ostorhazi; Ilona Kovalszky; Nina Bionda; Predrag Cudic; Eva Surmacz; John D. Wade; Ralf Hoffmann
Source:: Amino acids 2014 v.46 no.4 pp. 873-882
ISSN:: 0939-4451
Subject:: animal models; antagonists; biotin; blood serum; cattle; drugs; half life; humans; laboratory animals; leptin; leptin receptors; mice; myeloid leukemia; neoplasm cells; pharmacokinetics; surface plasmon resonance; tears
Abstract:: ... The leptin receptor antagonist peptide Allo-aca exhibits picomolar activities in various cellular systems and sub-mg/kg subcutaneous efficacies in animal models making it a prime drug candidate and target validation tool. Here we identified the biochemical basis for its remarkable in vivo activity. Allo-aca decomposed within 30 min in pooled human serum and was undetectable beyond the same time pe ...
DOI:: 10.1007/s00726-013-1650-6
: https://doi.org/10.1007/s00726-013-1650-6

Author:: Heather Nesbitt; Yingjie Sheng; Sukanta Kamila; Keiran Logan; Keith Thomas; Bridgeen Callan; Mark A. Taylor; Mark Love; Declan O'Rourke; Paul Kelly; Estelle Beguin; Eleanor Stride; Anthony P. McHale; John F. Callan
Source:: Journal of controlled release 2018 v.279 pp. 8-16
ISSN:: 0168-3659
Subject:: adverse effects; animal models; biotin; drug therapy; humans; ligands; mice; microbubbles; neoplasm cells; oxygen; pancreatic neoplasms; severe combined immunodeficiency; survival rate; toxicity; viability
Abstract:: ... Pancreatic cancer remains one of the most lethal forms of cancer with a 10-year survival of <1%. With little improvement in survival rates observed in the past 40 years, there is a significant need for new treatments or more effective strategies to deliver existing treatments. The antimetabolite gemcitabine (Gem) is the most widely used form of chemotherapy for pancreatic cancer treatment, but is ...
DOI:: 10.1016/j.jconrel.2018.04.018
: https://doi.org/10.1016/j.jconrel.2018.04.018

Author:: Zhaoxiang Liu; Hua Zhang; Hong Xia; Baocheng Wang; Renwen Zhang; Qun Zeng; Lingzhi Guo; Kui Shen; BaTa Wang; Yanheng Zhong; Zhizhong Li; Guodong Sun
Source:: Biochemical and biophysical research communications 2019 v.512 no.2 pp. 367-372
ISSN:: 0006-291X
Subject:: CD8-positive T-lymphocytes; animal injuries; animal models; biotin; cerebrospinal fluid; cytokines; enzyme-linked immunosorbent assay; flow cytometry; humans; infectious diseases; inflammation; mice; permeability; spinal cord; staining
Abstract:: ... Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin after spinal cord injury (SCI) on secondary inflammation. Compared recovery from SCI in perforin knockout (Prf1−/−) and wild-type(WT)mice, WT mic ...
DOI:: 10.1016/j.bbrc.2019.03.002
: https://doi.org/10.1016/j.bbrc.2019.03.002

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