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- Author:
- N. Cimolai; A.C.H. Cheong
- Source:
- Journal of applied microbiology 1997 v.82 no.5 pp. 625-630
- ISSN:
- 1364-5072
- Subject:
- Mycoplasma pneumoniae; actin; acute course; animal models; autoantibodies; fluorescent antibody technique; hamsters; humans; immunoblotting; immunoglobulin G; immunoglobulin M; infectious diseases; kidneys; mice; muscles; pathogenesis; patients; respiratory tract diseases; screening; smooth muscle; stomach
- Abstract:
- ... Autoantibody formation is possibly integral to the development of non‐respiratory manifestations of acute Mycoplasma pneumoniae infection. We sought to confirm the occurrence of smooth muscle antibodies (SMA) in humans with acute Myc. pneumoniae respiratory infection and furthermore to assess whether similar autoantibodies would develop in a hamster model of respiratory infection. Paired sera from ...
- DOI:
- 10.1111/j.1365-2672.1997.tb03594.x
- https://doi.org/10.1111/j.1365-2672.1997.tb03594.x
- Author:
- Mutwiri, G.; Pontarollo, R.; Babiuk, S.; Griebel, P.; Van Drunen Littel-van den Hurk, S.; Tsang, C.; Mena, A.; Alcon, V.; Nichani, A.; Ioannou, X.; Gomis, S.; Townsend, H.; Hecker, R.; Potter, A.; Babiuk, L.A.
- Source:
- Veterinary immunology and immunopathology 2003 v.91 no.2 pp. 89-103
- ISSN:
- 0165-2427
- Subject:
- DNA; Toll-like receptor 9; adaptive immunity; animal models; bioactive properties; clinical trials; cytokines; disease models; domestic animals; humans; hypersensitivity; immune response; infectious diseases; innate immunity; nucleotide motifs; oligodeoxyribonucleotides
- Abstract:
- ... Bacterial DNA contains a much higher frequency of CpG dinucleotides than are present in mammalian DNA. Furthermore, bacterial CpG dinucleotides are often not methylated. It is thought that these two features in combination with specific flanking bases constitute a CpG motif that is recognized as a “danger” signal by the innate immune system of mammals and therefore an immune response is induced wh ...
- DOI:
- 10.1016/S0165-2427(02)00246-5
- https://doi.org/10.1016/S0165-2427(02)00246-5
3. Experimental inhibition of nitric oxide increases Plasmodium relictum (lineage SGS1) parasitaemia
- Author:
- Coraline Bichet; Stéphane Cornet; Stephen Larcombe; Gabriele Sorci
- Source:
- Experimental parasitology 2012 v.132 no.4 pp. 417-423
- ISSN:
- 0014-4894
- Subject:
- Plasmodium relictum; anemia; animal models; avian malaria; canaries; enzyme inhibition; humans; immune system; inducible nitric oxide synthase; infectious diseases; nitric oxide; parasitemia; parasites; parasitology; reptiles; rodents; vector-borne diseases; wildlife
- Abstract:
- ... Malaria is a widespread vector-borne disease infecting a wide range of terrestrial vertebrates including reptiles, birds and mammals. In addition to being one of the most deadly infectious diseases for humans, malaria is a threat to wildlife. The host immune system represents the main defence against malaria parasites. Identifying the immune effectors involved in malaria resistance has therefore b ...
- DOI:
- 10.1016/j.exppara.2012.09.008
- https://doi.org/10.1016/j.exppara.2012.09.008
- Author:
- M. Sparo; L. Urbizu; M.V. Solana; G. Pourcel; G. Delpech; A. Confalonieri; M. Ceci; S.F. Sánchez Bruni
- Source:
- Letters in applied microbiology 2012 v.54 no.2 pp. 119-125
- ISSN:
- 0266-8254
- Subject:
- Enterococcus faecalis; Escherichia coli; animal models; ceftriaxone; feces; food animals; foods; gene transfer; gentamicin; humans; in vitro studies; in vivo studies; infectious diseases; mice; minimum inhibitory concentration; pathogens; plasmids
- Abstract:
- ... Aims: To investigate the in vivo gene transfer of high‐level gentamicin resistance (HLRG) from Enterococcus faecalis isolated from the food of animal origin to a human isolate, using a mouse model of intestinally colonized human microbiota. Methods and Results: In vitro study: The presence of plasmids involved in HLRG coding was investigated. After the conjugation experiment, the recipient strain, ...
- DOI:
- 10.1111/j.1472-765X.2011.03182.x
- PubMed:
- 22098378
- https://doi.org/10.1111/j.1472-765X.2011.03182.x
- Author:
- Abdelaziz S.A. Abuelsaad; Imad Mohamed; Gamal Allam; Adnan A. Al-Solumani
- Source:
- Life sciences 2013 v.93 no.20 pp. 714-722
- ISSN:
- 0024-3205
- Subject:
- Aeromonas hydrophila; animal models; anti-infective properties; antigens; bacterial colonization; clinical trials; ellagic acid; gastrointestinal system; hesperidin; histopathology; humans; humoral immunity; immunocompromised population; immunoglobulin A; immunoglobulin M; infectious diseases; medicinal plants; mice; minimum inhibitory concentration; normal values; pathogens; sepsis (infection)
- Abstract:
- ... AIMS: The present study is designed to evaluate the in vitro and in vivo bactericidal and immunomodulating activities of hesperidin (HES) and ellagic acid (EA) against Aeromonas hydrophila. A hydrophila, an uncommon human pathogen, can cause invasive infections in immunocompromised individuals and common clinical presentations in acute gastrointestinal illness, soft-tissue infections and sepsis. T ...
- DOI:
- 10.1016/j.lfs.2013.09.019
- https://doi.org/10.1016/j.lfs.2013.09.019
- Author:
- Stefan Weichert; Stefan Jennewein; Eric Hüfner; Christel Weiss; Julia Borkowski; Johannes Putze; Horst Schroten
- Source:
- Nutrition research 2013 v.33 no.10 pp. 831-838
- ISSN:
- 0271-5317
- Subject:
- Campylobacter jejuni; Pseudomonas aeruginosa; Salmonella enterica; adhesion; animal models; bioactive properties; breast milk; clinical trials; enteropathogenic Escherichia coli; humans; infant formulas; infants; infectious diseases; oligosaccharides; pathogens
- Abstract:
- ... Human milk oligosaccharides help to prevent infectious diseases in breastfed infants. Larger scale testing, particularly in animal models and human clinical studies, is still limited due to shortened availability of more complex oligosaccharides. The purpose of this study was to evaluate 2′-fucosyllactose (2′-FL) and 3-fucosyllactose (3-FL) synthesized by whole-cell biocatalysis for their biologic ...
- DOI:
- 10.1016/j.nutres.2013.07.009
- PubMed:
- 24074741
- https://doi.org/10.1016/j.nutres.2013.07.009
- Author:
- Karl O.A. Yu; Steven A. Porcelli; Howard A. Shuman
- Source:
- Journal of Immunological Methods 2013 v.389 pp. 88-94
- ISSN:
- 0022-1759
- Subject:
- Legionella pneumophila; Mycobacterium tuberculosis; animal models; antigen presentation; bacteria; bone marrow; guinea pigs; humans; in vitro studies; infectious diseases; macrophage colony-stimulating factor; macrophages; mice; pathogenesis; phagocytosis
- Abstract:
- ... The guinea pig has a storied history as a model in the study of infectious disease and immunology. Because of reproducibility of data and availability of various reagents, inbred mice have since supplanted the guinea pig as the animal model-of-choice in these fields. However, several clinically-significant microorganisms do not cause the same pathology in mice, or mice may not be susceptible to th ...
- DOI:
- 10.1016/j.jim.2013.01.005
- https://doi.org/10.1016/j.jim.2013.01.005
- Author:
- Francesco Celandroni; Sara Salvetti; Sonia Senesi; Emilia Ghelardi
- Source:
- FEMS microbiology letters 2014 v.361 no.2 pp. 95-103
- ISSN:
- 0378-1097
- Subject:
- Bacillus cereus; Bacillus thuringiensis; animal models; bacteremia; enterotoxins; forestry; hemolysins; humans; infectious diseases; periodontitis; phospholipase C; virulence
- Abstract:
- ... Bacillus thuringiensis is widely used as a biopesticide in forestry and agriculture, being able to produce potent species‐specific insecticidal toxins and considered nonpathogenic to other animals. More recently, however, repeated observations are documenting the association of this microorganism with various infectious diseases in humans, such as food‐poisoning‐associated diarrheas, periodontitis ...
- DOI:
- 10.1111/1574-6968.12615
- https://doi.org/10.1111/1574-6968.12615
- Author:
- Gwendolyn J.B. Jones; Corey Boles; Rachel L. Roper
- Source:
- Vaccine 2014 v.32 no.31 pp. 3977-3981
- ISSN:
- 0264-410X
- Subject:
- infectious diseases; Rabies lyssavirus; antigens; humans; neoplasms; hosts; vaccines; heart diseases; virulence; eczema; animal models; genes; Vaccinia virus; immune response; severe combined immunodeficiency; glycoproteins
- Abstract:
- ... Numerous poxviruses infect humans and animal hosts, and a poxvirus vaccine with an improved safety profile is needed as the current vaccinia virus vaccine is contraindicated in individuals that have a history of eczema or heart disease, or are immunocompromised or pregnant. In addition, poxviruses make excellent vaccine vectors for other infectious diseases and cancer. Raccoonpoxvirus is a natural ...
- DOI:
- 10.1016/j.vaccine.2014.05.018
- https://doi.org/10.1016/j.vaccine.2014.05.018
- Author:
- José L. Arias; Juan D. Unciti-Broceta; José Maceira; Teresa del Castillo; José Hernández-Quero; Stefan Magez; Miguel Soriano; José A. García-Salcedo
- Source:
- Journal of controlled release 2015 v.197 pp. 190-198
- ISSN:
- 0168-3659
- Subject:
- African trypanosomiasis; Trypanosoma brucei; acute course; animal models; antibodies; chemical bonding; drugs; endocytosis; humans; infectious diseases; inhibitory concentration 50; mice; nanocarriers; nanoparticles; pathogens; trypanocides; variant surface glycoproteins
- Abstract:
- ... Targeted delivery of therapeutics is an alternative approach for the selective treatment of infectious diseases. The surface of African trypanosomes, the causative agents of African trypanosomiasis, is covered by a surface coat consisting of a single variant surface glycoprotein, termed VSG. This coat is recycled by endocytosis at a very high speed, making the trypanosome surface an excellent targ ...
- DOI:
- 10.1016/j.jconrel.2014.11.002
- https://doi.org/10.1016/j.jconrel.2014.11.002
- Author:
- W. Ernst
- Source:
- Comparative immunology, microbiology, and infectious diseases 2016 v.49 pp. 29-38
- ISSN:
- 0147-9571
- Subject:
- animal models; bacteria; humans; immune response; immune system; infectious diseases; mice; parasites; pathogenesis; pathogens; vaccines; viruses
- Abstract:
- ... The pathogenesis of infectious agents with human tropism can only be properly studied in an in vivo model featuring human cells or tissue. Humanized mice represent a small animal model featuring human cells or tissue that can be infected by human-specific viruses, bacteria, and parasites and also providing a functional human immune system. This makes the analysis of a human immune response to infe ...
- DOI:
- 10.1016/j.cimid.2016.08.006
- https://doi.org/10.1016/j.cimid.2016.08.006
- Author:
- T. Veiga-Parga
- Source:
- Veterinary pathology v.53 no.4 pp. 737-745
- ISSN:
- 1544-2217
- Subject:
- T-lymphocytes; animal health; animal models; animal pathology; antigen-presenting cells; autoimmunity; domestic animals; humans; immune response; neoplasms
- Abstract:
- ... In humans and mouse models, Foxp3⁺ regulatory T cells are known to control all aspects of immune responses. However, only limited information exists on these cells’ role in diseases of other animals. In this review, we cover the most important features and different types of regulatory T cells, which include those that are thymus-derived and peripherally induced, the mechanisms by which they contr ...
- DOI:
- 10.1177/0300985816629719
- https://doi.org/10.1177/0300985816629719
- Author:
- Annie S.P. Yang; Justin A. Boddey
- Source:
- International journal for parasitology 2017 v.47 no.2-3 pp. 129-136
- ISSN:
- 0020-7519
- Subject:
- Culicidae; Plasmodium; animal models; gross domestic product; humans; infectious diseases; liver; malaria; morbidity; parasites; people; sporozoites; virulence
- Abstract:
- ... Malaria is a pernicious infectious disease caused by apicomplexan parasites of the genus Plasmodium. Each year, malaria afflicts over 200million people, causing considerable morbidity, loss to gross domestic product of endemic countries, and more than 420,000 deaths. A central feature of the virulence of malaria parasites is the ability of sporozoite forms injected by a mosquito to navigate from t ...
- DOI:
- 10.1016/j.ijpara.2016.09.002
- https://doi.org/10.1016/j.ijpara.2016.09.002
- Author:
- Zhen Liu; Yu Wu; Ying Feng; Feng Wu; Rui-Feng Liu; Li-Fu Wang; Jin-Yi Liang; Jia-Hua Liu; Xi Sun; Zhong-Dao Wu
- Source:
- Parasitology research 2017 v.116 no.2 pp. 577-587
- ISSN:
- 0932-0113
- Subject:
- Parastrongylus cantonensis; T-lymphocytes; albendazole; animal models; atrophy; brain; hosts; humans; immunopathology; immunosuppression; infectious diseases; inflammation; mice; spleen; splenocytes
- Abstract:
- ... The spleen is one of the most important peripheral immune organs, which is frequently affected in infectious diseases. Infectious diseases can induce splenic alterations including splenic atrophy and functional alteration, while splenic atrophy may in turn interferes with recovery of infectious diseases. Angiostrongyliasis is an infectious disease by Angiostrongylus cantonensis (A. cantonensis), w ...
- DOI:
- 10.1007/s00436-016-5322-9
- https://doi.org/10.1007/s00436-016-5322-9
- Author:
- Shanshan Hu; Wei Wei; Heinrich Korner
- Source:
- Molecular Immunology 2017 pp. -
- ISSN:
- 0161-5890
- Subject:
- Protozoa; animal models; bone marrow; chemical elements; dendritic cells; homeostasis; human diseases; humans; inflammation; innate immunity; macrophages; monocytes; ontogeny; parasites; parasitoses; pathogens
- Abstract:
- ... The confirmation of developmental differences between tissue macrophages and peripheral monocytes has changed our view of the functions and dynamics of these two important components of the innate immune system. It has been demonstrated conclusively that homeostasis of tissue resident macrophages is maintained by a low proliferative turn over. During an inflammatory response, bone marrow derived m ...
- DOI:
- 10.1016/j.molimm.2017.06.020
- https://doi.org/10.1016/j.molimm.2017.06.020
- Author:
- Hui Liu; Zhenghu Jia; Chengmao Yang; Mei Song; Zhe Jing; Yapu Zhao; Zhenzhou Wu; Liqing Zhao; Dongsheng Wei; Zhinan Yin; Zhangyong Hong
- Source:
- Biomaterials 2018 v.167 pp. 32-43
- ISSN:
- 0142-9612
- Subject:
- adjuvants; alum; aluminum hydroxide; animal models; antibodies; antigens; beta-glucans; cell-mediated immunity; colloids; cytokines; dendritic cells; humans; humoral immunity; immune response; infectious diseases; mixing; neoplasms; proteins; secretion; vaccination; vaccines; yeasts
- Abstract:
- ... Aluminum salt (Alum) is one of the most important immune adjuvants approved for use in humans, however it is not suitable for vaccination against various chronic infectious diseases and cancers for not being able to induce cell-mediated (Th1) immunity. Here, we encapsulated an Alum colloid inside β-glucan particles (GPs), which are a type of natural particles derived from the yeast glucan shells, ...
- DOI:
- 10.1016/j.biomaterials.2018.03.014
- https://doi.org/10.1016/j.biomaterials.2018.03.014
- Author:
- Eita Sasaki; Haruka Momose; Yuki Hiradate; Takuo Mizukami; Isao Hamaguchi
- Source:
- Vaccine 2018 v.36 no.46 pp. 7112-7118
- ISSN:
- 0264-410X
- Subject:
- adverse effects; animal models; biomarkers; clinical trials; edema; fever; humans; infectious diseases; influenza vaccines; innate immunity; pain; pathogens; prediction; quality control; risk; safety assessment; screening; toxicity; vaccination; vaccine adjuvants
- Abstract:
- ... Vaccines effectively prevent infectious diseases. Many types of vaccines against various pathogens that threaten humans are currently in widespread use. Recently, adjuvant adaptation has been attempted to activate innate immunity to enhance the effectiveness of vaccines. The effectiveness of adjuvants for vaccinations has been demonstrated in many animal models and clinical trials. Although a high ...
- DOI:
- 10.1016/j.vaccine.2018.10.009
- https://doi.org/10.1016/j.vaccine.2018.10.009
- Author:
- Stefania Marsico; Francesca Caccuri; Pietro Mazzuca; Paola Apostoli; Sara Roversi; Giovanni Lorenzin; Alberto Zani; Simona Fiorentini; Cinzia Giagulli; Arnaldo Caruso
- Source:
- Pathogens and disease 2018 v.76 no.2 pp. -
- ISSN:
- 2049-632X
- Subject:
- B-cell lymphoma; Human metapneumovirus; NAD ADP-ribosyltransferase; acute course; animal models; animal viruses; apoptosis; asthma; caspase-3; cell cycle checkpoints; cell structures; childhood; children; epithelial cells; epithelium; humans; infectious diseases; lungs; viruses
- Abstract:
- ... Human metapneumovirus (hMPV) has been identified as a major cause of lower respiratory tract infection in children. Epidemiological and molecular evidence has highlighted an association between severe childhood respiratory viral infection and chronic lung diseases, such as asthma and chronic obstructive pulmonary disease. Currently, animal models have demonstrated the ability of hMPV to persist in ...
- DOI:
- 10.1093/femspd/fty013
- https://doi.org/10.1093/femspd/fty013
- Author:
- Feng Zhu; Yinling Hu
- Source:
- BioEssays 2018 v.40 no.4 pp. e1700131
- ISSN:
- 0265-9247
- Subject:
- IKappaB kinase; T-lymphocytes; animal models; autoimmunity; carcinogenesis; epithelial cells; fungi; humans; immunosuppression; infectious diseases; loci; mice; severe combined immunodeficiency; squamous cell carcinoma; thymus gland; transcription factor NF-kappa B
- Abstract:
- ... A pathogenic connection between autoreactive T cells, fungal infection, and carcinogenesis has been demonstrated in studies of human autoimmune polyendocrinopathy‐candidiasis‐ectodermal dystrophy (APECED) as well as in a mouse model in which kinase‐dead Ikkα knock‐in mice develop impaired central tolerance, autoreactive T cell–mediated autoimmunity, chronic fungal infection, and esophageal squamou ...
- DOI:
- 10.1002/bies.201700131
- https://doi.org/10.1002/bies.201700131
- Author:
- Astrid Tannert; Anuradha Ramoji; Ute Neugebauer; Jürgen Popp
- Source:
- Analytical and bioanalytical chemistry 2018 v.410 no.3 pp. 773-790
- ISSN:
- 1618-2642
- Subject:
- animal models; antibiotic resistance; antibiotics; blood; death; humans; infectious diseases; monitoring; new drugs; pathogens; patients; photonics; photons; septic shock; survival rate; therapeutics
- Abstract:
- ... Despite the strong decline in the infection-associated mortality since the development of the first antibiotics, infectious diseases are still a major cause of death in the world. With the rising number of antibiotic-resistant pathogens, the incidence of deaths caused by infections may increase strongly in the future. Survival rates in sepsis, which occurs when body response to infections becomes ...
- DOI:
- 10.1007/s00216-017-0713-z
- https://doi.org/10.1007/s00216-017-0713-z