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- Author:
- Jingna Wu; Xiaoting Chen; Kun Qiao; Yongchang Su; Zhiyu Liu
- Source:
- Food science and human wellness 2021 v.10 no.1 pp. 63-71
- ISSN:
- 2213-4530
- Subject:
- Bangia; acid hydrolysis; animal ovaries; anion exchange; antineoplastic activity; arabinose; galactose; gas chromatography-mass spectrometry; gel chromatography; glucose; mannose; methylation; molecular weight; neoplasm cells; nuclear magnetic resonance spectroscopy; ovarian neoplasms; polysaccharides; rhamnose; water solubility
- Abstract:
- ... A water-soluble polysaccharide, designated BFP-3, was isolated from Bangia fuscopurpurea by hot water extraction, anion-exchange, and size-exclusion chromatography and tested to determine its antitumor activity. The structural characteristics of BFP-3 were investigated by chemical and spectroscopic methods, including partial acid hydrolysis, methylation analysis, one- and two-dimensional nuclear m ...
- DOI:
- 10.1016/j.fshw.2020.05.003
- https://doi.org/10.1016/j.fshw.2020.05.003
- Author:
- Min Ju Kim; So Jin Lee; Ju Hee Ryu; Sun Hwa Kim; Ick Chan Kwon; Thomas M. Roberts
- Source:
- Journal of controlled release 2020 v.318 pp. 98-108
- ISSN:
- 0168-3659
- Subject:
- allografting; animal ovaries; antineoplastic activity; apoptosis; carcinogenesis; cell proliferation; chitosan; drug development; drug resistance; enzyme inhibition; gene silencing; models; mutation; ovarian neoplasms; phosphatidylinositol 3-kinase; polymerization; signal transduction; small interfering RNA
- Abstract:
- ... The phosphoinositide 3-kinase (PI3K) and RAS signaling pathways are frequently co-activated and altered during oncogenesis. Owing to their regulatory cross-talk, the early attempts of targeting only one pathway have mostly ended up promoting the development of drug resistance. Here, we propose using small interfering RNA (siRNA) therapeutics to directly target the undruggable KRAS (siKRAS) in comb ...
- DOI:
- 10.1016/j.jconrel.2019.12.019
- PubMed:
- 31838203
- PubMed Central:
- PMC7056267
- https://doi.org/10.1016/j.jconrel.2019.12.019
- Author:
- Jingjing Li; Fan Tang; Renkai Li; Zhejie Chen; Simon Ming-Yuen Lee; Chaomei Fu; Jinming Zhang; George Pak-Heng Leung
- Source:
- Journal of nutritional biochemistry 2020 v.77 pp. 108268
- ISSN:
- 0955-2863
- Subject:
- Danio rerio; angiogenesis; animal ovaries; antineoplastic activity; apoptosis; bioactive compounds; blood vessels; caspase-3; caspase-9; cell cycle checkpoints; cyclins; ex vivo studies; glycyrrhetinic acid; human umbilical vein endothelial cells; in vitro studies; in vivo studies; interphase; licorice; mechanism of action; membrane potential; mice; mitochondrial membrane; mitogen-activated protein kinase; models; neoplasm cells; ovarian neoplasms; phosphorylation; pro-apoptotic proteins; rats; receptors; signal transduction; vascular endothelial growth factor receptor-2
- Abstract:
- ... Glycyrrhetinic acid (GA) is a major bioactive compound of licorice. The objective of this study was to investigate the effects of GA on ovarian cancer, particularly those related to angiogenesis and apoptosis, and to elucidate the underlying mechanisms of action. In vitro studies showed that GA significantly inhibited proliferation, migration, invasion and tube formation in human umbilical vein en ...
- DOI:
- 10.1016/j.jnutbio.2019.108268
- https://doi.org/10.1016/j.jnutbio.2019.108268
- Author:
- Jinju Lee; Young Jae Cho; Jeong-Won Lee; Hyung Jun Ahn
- Source:
- Journal of controlled release 2020 v.321 pp. 184-197
- ISSN:
- 0168-3659
- Subject:
- animal ovaries; antineoplastic activity; antineoplastic agents; drug resistance; drug synergism; induced resistance; kinesin; microtubules; models; neoplasm cells; ovarian neoplasms; paclitaxel; small interfering RNA; therapeutics
- Abstract:
- ... Despite the promising anticancer effects of kinesin spindle protein (KSP) inhibition, functional plasticity of kinesins induced resistance against KSP inhibitors in a variety of cancers, leading to clinical failure. Additionally, paclitaxel is a widely used anticancer agent, but drug resistance has limited its use in the recurrent cancers. To overcome resistance against KSP inhibitors, we paired K ...
- DOI:
- 10.1016/j.jconrel.2020.02.013
- https://doi.org/10.1016/j.jconrel.2020.02.013
- Author:
- Jae Ryul Bae; Wook Ha Park; Dong Hoon Suh; Jae Hong No; Yong Beom Kim; Kidong Kim
- Source:
- BMC complementary medicine and therapies 2020 v.20 no.1 pp. 94
- ISSN:
- 2662-7671
- Subject:
- Euodia; adverse effects; animal ovaries; antineoplastic activity; antineoplastic agents; apoptosis; cancer therapy; cell viability; drug resistance; drug therapy; fluorescent antibody technique; fractionation; human cell lines; immunoblotting; limonin; neoplasm cells; ovarian neoplasms; patients; signal transduction; staining
- Abstract:
- ... BACKGROUND: Ovarian cancer therapy generally involves systemic chemotherapy with anticancer drugs; however, chemotherapy with a platinum-based drug has often been shown to cause adverse reactions and drug resistance in ovarian cancer patients. Evodia rutaecarpa (ER) reportedly shows anticancer activity against various types of cancer cells. However, the effects of ER have not yet been fully uncove ...
- DOI:
- 10.1186/s12906-020-02890-y
- PubMed:
- 32197606
- PubMed Central:
- PMC7085187
- https://doi.org/10.1186/s12906-020-02890-y
- Author:
- Molood Shariati; Giovanna Lollo; Kevin Matha; Benedicte Descamps; Christian Vanhove; Leen Van de Sande; Wouter Willaert; Lieve Balcaen; Frank Vanhaecke; Jean-Pierre Benoit; Wim Ceelen; Stefaan C. De Smedt; Katrien Remaut
- Source:
- ACS applied materials & interfaces 2020 v.12 no.26 pp. 29024-29036
- ISSN:
- 1944-8252
- Subject:
- abdominal cavity; aerosols; animal models; animal ovaries; antineoplastic activity; cisplatin; drug therapy; fluorescence; human diseases; metastasis; nanocarriers; nanomedicine; nanoparticles; ovarian neoplasms; patients; surgery; synergism
- Abstract:
- ... Intra-abdominal dissemination of peritoneal nodules, a condition known as peritoneal carcinomatosis (PC), is typically diagnosed in ovarian cancer patients at the advanced stages. The current treatment of PC consists of perioperative systemic chemotherapy and cytoreductive surgery, followed by intra-abdominal flushing with solutions of chemotherapeutics such as cisplatin and oxaliplatin. In this s ...
- DOI:
- 10.1021/acsami.0c05554
- https://doi.org/10.1021/acsami.0c05554
- Author:
- Xiang-Qi Zhang; Ya-Wei Ding; Jun-Jun Chen; Xiao Xiao; Wei Zhang; Li Zhou; Qian-Wen Kong; Mei-Zhi Shi; Jiao Yang; Bo Jiang; Cheng Guo; Yong-Long Han
- Source:
- Journal of ethnopharmacology 2020 v.261 pp. 113067
- ISSN:
- 0378-8741
- Subject:
- Marsdenia tenacissima; P-glycoproteins; Western blotting; adjuvants; animal models; animal ovaries; antineoplastic activity; apoptosis; cell cycle; cell proliferation; drug therapy; dyeing; enzymes; flow cytometry; messenger RNA; mice; ovarian neoplasms; paclitaxel; plasmids; pregnanes; pro-apoptotic proteins; protein synthesis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; rhodamines; small interfering RNA; synergism; tissues; toxicity testing; traditional medicine; China
- Abstract:
- ... Xiaoaiping injection, a traditional Chinese medical injection extracted from root of Marsdenia tenacissima (Roxb.) Moon, has been exclusively used on curing malignant tumor in China and as adjuvant therapeutic agent for chemotherapeutics, including paclitaxel.The goal of this study was to investigate the synergistic inhibitory efficacy of Xiaoaiping injection and paclitaxel on ovarian cancer. The ...
- DOI:
- 10.1016/j.jep.2020.113067
- https://doi.org/10.1016/j.jep.2020.113067
- Author:
- Nana Bie; Lirong Han; Meng Meng; Yuanyuan Zhang; Mingzhu Guo; Chunling Wang
- Source:
- Journal of functional foods 2020 v.65 pp. 103739
- ISSN:
- 1756-4646
- Subject:
- T-lymphocytes; animal models; animal ovaries; antineoplastic activity; apoptosis; caspase-3; cell proliferation; cytochrome c; eicosapentaenoic acid; human diseases; immunomodulators; macrophages; mitogen-activated protein kinase; natural killer cells; neoplasm cells; ovarian neoplasms; phagocytosis; phosphatidylinositol 3-kinase; phosphorylation; rats; spleen; splenocytes; thymus gland; transcription factor NF-kappa B
- Abstract:
- ... Eicosapentaenoic acid (EPA) has been known to induce human ovarian cancer cells apoptosis in vitro. However, the anti-tumor mechanisms of EPA in vivo have been rarely reported. In this study, the effect of EPA on the ovarian cancer rat model and its related mechanism were investigated. The results showed after EPA treatment, the index of spleens and thymus was significantly increased, and the prol ...
- DOI:
- 10.1016/j.jff.2019.103739
- https://doi.org/10.1016/j.jff.2019.103739
- Author:
- Haiqin SongThe two authors contributed equally to this work.; Feifei Quan; Zhiqiang Yu; Minhua Zheng; Yan Ma; Haihua Xiao; Fang Ding
- Source:
- Journal of materials chemistry B 2019 v.7 no.3 pp. 433-442
- ISSN:
- 2050-7518
- Subject:
- adverse effects; animal ovaries; antineoplastic activity; cell lines; chemistry; cisplatin; cytotoxicity; drug resistance; endocytosis; in vivo studies; iron oxides; magnetic fields; nanocarriers; nanoparticles; neoplasm cells; ovarian neoplasms; platinum; toxicity testing; zeta potential
- Abstract:
- ... Platinum (Pt)-based drugs including cisplatin, carboplatin and oxaliplatin have been widely used as first-line anticancer regimens due to their excellent anticancer efficacy. However, the clinical application of these drugs is greatly limited due to their side effects and drug resistance. In this study, an antitumor drug delivery system based on carboplatin prodrug loading Fe₃O₄ nanoparticles (NPs ...
- DOI:
- 10.1039/c8tb02574f
- https://doi.org/10.1039/c8tb02574f
- Author:
- Justyna Mikuła-Pietrasik; Anna Witucka; Martyna Pakuła; Paweł Uruski; Beata Begier-Krasińska; Arkadiusz Niklas; Andrzej Tykarski; Krzysztof Książek
- Source:
- Cellular and molecular life sciences 2019 v.76 no.4 pp. 681-697
- ISSN:
- 1420-682X
- Subject:
- DNA damage; angiogenesis; animal ovaries; antineoplastic activity; apoptosis; cell senescence; drug therapy; drugs; endothelial cells; epithelial cells; fibroblasts; metabolism; mitophagy; neurons; ovarian neoplasms; oxidative stress; somatic cells
- Abstract:
- ... One of the most neglected aspects of chemotherapy are changes, and possible consequences of these changes, that occur in normal somatic cells. In this review, we summarize effects of selected drugs used to treat ovarian cancer (platin derivatives—cisplatin and carboplatin; and taxanes—paclitaxel and docetaxel) on cellular metabolism, acquisition of reactive stroma features, cellular senescence, in ...
- DOI:
- 10.1007/s00018-018-2954-1
- PubMed:
- 30382284
- PubMed Central:
- PMC6514066
- https://doi.org/10.1007/s00018-018-2954-1
- Author:
- Eunbi Jo; Hyun-Jin Jang; Kyeong Eun Yang; Min Su Jang; Yang Hoon Huh; Hwa-Seung Yoo; Jun Soo Park; Ik-Soon Jang; Soo Jung Park
- Source:
- BMC complementary medicine and therapies 2020 v.20 no.1 pp. 1
- ISSN:
- 2662-7671
- Subject:
- B-cell lymphoma; Cordyceps militaris; animal ovaries; antineoplastic activity; apoptosis; caspases; cell proliferation; cell viability; cytosol; dose response; immunoblotting; immunocytochemistry; interleukin-1beta; mechanism of action; microarray technology; neoplasm cells; ovarian neoplasms; phosphorylation; transcription factor NF-kappa B; transmission electron microscopy; tumor necrosis factor receptors; tumor necrosis factor-alpha
- Abstract:
- ... BACKGROUND: Cordyceps militaris (L.) Fr. (C. militaris) exhibits pharmacological activities, including antitumor properties, through the regulation of the nuclear factor kappa B (NF-κB) signaling. Tumor Necrosis Factor (TNF) and TNF-α modulates cell survival and apoptosis through NF- κB signaling. However, the mechanism underlying its mode of action on the NF-κB pathway is unclear. METHODS: Here, ...
- DOI:
- 10.1186/s12906-019-2780-5
- PubMed:
- 32020859
- PubMed Central:
- PMC7076896
- https://doi.org/10.1186/s12906-019-2780-5
- Author:
- Luis Varela-Rodríguez; Blanca Sánchez-Ramírez; Verónica Ivonne Hernández-Ramírez; Hugo Varela-Rodríguez; Rodrigo Daniel Castellanos-Mijangos; Carmen González-Horta; Bibiana Chávez-Munguía; Patricia Talamás-Rohana
- Source:
- BMC complementary medicine and therapies 2020 v.20 no.1 pp. 110
- ISSN:
- 2662-7671
- Subject:
- adenocarcinoma; alanine transaminase; analysis of variance; animal ovaries; antineoplastic activity; antineoplastic agents; apoptosis; carbonate dehydratase; cell cycle checkpoints; cell viability; chronic hepatitis; computer simulation; dimethyl sulfoxide; females; gallic acid; histopathology; in vitro studies; in vivo studies; intravenous injection; leukocytes; liver; mice; models; mortality; myricetin; nuclear magnetic resonance spectroscopy; ovarian neoplasms; paclitaxel; parenchyma (animal tissue); phosphatidylinositol 3-kinase; platinum; resection; taxanes; toxicology; transmission electron microscopy; urea
- Abstract:
- ... BACKGROUND: Ovarian cancer is the leading cause of mortality among malignant gynecological tumors. Surgical resection and chemotherapy with intravenous platinum/taxanes drugs are the treatments of choice, with little effectiveness in later stages and severe toxicological effects. Therefore, this study aimed to evaluate the antineoplastic activity of gallic acid (GA) and myricetin (Myr) administrat ...
- DOI:
- 10.1186/s12906-020-02900-z
- PubMed:
- 32276584
- PubMed Central:
- PMC7149887
- https://doi.org/10.1186/s12906-020-02900-z
- Author:
- Jinsha Koroth; Snehal Nirgude; Shweta Tiwari; Vidya Gopalakrishnan; Raghunandan Mahadeva; Sujeet Kumar; Subhas S. Karki; Bibha Choudhary
- Source:
- BMC complementary and alternative medicine 2019 v.19 no.1 pp. 273
- ISSN:
- 1472-6882
- Subject:
- Western blotting; adverse effects; alternative medicine; animal ovaries; antineoplastic activity; apoptosis; bioavailability; breast neoplasms; cell lines; cell movement; curcumin; cytotoxicity; flow cytometry; interstitial collagenase; liquids; metastasis; neoplasm cells; ovarian neoplasms; stem cells; toxicity testing
- Abstract:
- ... BACKGROUND: Curcumin is known for its multitude of medicinal properties, including anti-cancer and migrastatic activity. Efforts to overcome poor bioavailability, stability, and side effects associated with the higher dose of curcumin has led to the development of newer derivatives of curcumin. Thus, the focus of this study is to screen novel curcumin derivatives, namely ST03 and ST08, which have ...
- DOI:
- 10.1186/s12906-019-2685-3
- PubMed:
- 31638975
- PubMed Central:
- PMC6802352
- https://doi.org/10.1186/s12906-019-2685-3
- Author:
- Yanyan Jia; Huirong Shi; Yuan Cao; Wenlong Feng; Meijuan Li; Xueru Li
- Source:
- Life sciences 2019 v.233 pp. 116715
- ISSN:
- 0024-3205
- Subject:
- animal ovaries; antineoplastic activity; carcinogenesis; cell growth; gene overexpression; lymph nodes; metastasis; neoplasm cells; ovarian neoplasms; patients; phosphorylation; prognosis; therapeutics; tissues; transcriptional activation
- Abstract:
- ... PDZ and LIM domain protein 4 (PDLIM4) is frequently repressed in cancer tissues. However, the expression and role of PDLIM4 in ovarian cancer has not been addressed.In this study, we examined the expression and prognostic significance of PDLIM4 in ovarian cancer. The function of PDLIM4 in ovarian cancer cell growth, invasion, and tumorigenesis was further explored.PDLIM4 is downregulated in ovaria ...
- DOI:
- 10.1016/j.lfs.2019.116715
- https://doi.org/10.1016/j.lfs.2019.116715
- Author:
- Umasankar De; Ji Yeon Son; Yukyoung Jeon; Song-Yi Ha; Yu Jin Park; Sungpil Yoon; Ki-Tae Ha; Wahn Soo Choi; Byung Mu Lee; In Su Kim; Jong Hwan Kwak; Hyung Sik Kim
- Source:
- Food and chemical toxicology 2019 v.123 pp. 492-500
- ISSN:
- 0278-6915
- Subject:
- Nepenthes alata; adverse effects; animal models; animal ovaries; antineoplastic activity; apoptosis; breast neoplasms; cell cycle checkpoints; cyclins; cysteine; cytochrome c; cytotoxicity; epithelium; humans; mice; neoplasm cells; ovarian neoplasms; plumbagin; reactive oxygen species; therapeutics
- Abstract:
- ... Plumbagin (5-hydroxy-2-methyl-1,4-naphthaquinone) has displayed antitumor activity in vitro and in animal models; however, the underlying molecular mechanisms have not been fully explored. The aim of this study was to investigate the anticancer effects of plumbagin isolated from Nepenthes alata against MCF-7 breast cancer cells. We examined the cytotoxicity, cell cycle regulation, apoptotic cell d ...
- DOI:
- 10.1016/j.fct.2018.11.040
- https://doi.org/10.1016/j.fct.2018.11.040
- Author:
- Peng-Cheng LIN; Lin-Lin JI; Xiang-Jian ZHONG; Jin-Jie LI; Xin WANG; Xiao-Ya SHANG; Sheng LIN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.1 pp. 22-26
- ISSN:
- 1875-5364
- Subject:
- Cirsium arvense; Oriental traditional medicine; animal ovaries; antineoplastic activity; cell lines; chemical structure; colorectal neoplasms; cytotoxicity; food plants; humans; inhibitory concentration 50; ovarian neoplasms; secretion; spectral analysis; triterpenoids; tumor necrosis factor-alpha
- Abstract:
- ... Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD d ...
- DOI:
- 10.1016/S1875-5364(19)30005-6
- https://doi.org/10.1016/S1875-5364(19)30005-6
- Author:
- Sha Xiao; Ming Zhang; Chang Liu; Deling Wang
- Source:
- Molecular genetics and genomics 2018 v.293 no.5 pp. 1159-1167
- ISSN:
- 1617-4615
- Subject:
- adenosine triphosphate; animal ovaries; antineoplastic activity; cisplatin; data collection; drug therapy; gene expression; luciferase; neoplasm cells; ovarian neoplasms; patients; prognosis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction
- Abstract:
- ... Cisplatin is one of the most popular chemotherapeutic drugs in treating ovarian cancer. Resistance to cisplatin is a common clinical challenge that needs to be solved to increase its anti-tumor effects. The relation of miR-514 expression with prognosis in ovarian cancer patients was analyzed based on GSE73584 datasets. The regulation of miR-514 on proliferation and cisplatin chemosensitivity of ov ...
- DOI:
- 10.1007/s00438-018-1447-0
- https://doi.org/10.1007/s00438-018-1447-0
- Author:
- Wenshuang Wu; Yang Liu; Haoyu Ye; Zhihui Li
- Source:
- Phytotherapy research 2018 v.32 no.12 pp. 2428-2435
- ISSN:
- 0951-418X
- Subject:
- ABC transporters; DNA topoisomerase (ATP-hydrolysing); Millettia pachycarpa; animal ovaries; antineoplastic activity; apoptosis; chalcone; cisplatin; drug resistance; enzyme activity; herbal medicines; humans; mice; models; neoplasm cells; ovarian neoplasms; research and development
- Abstract:
- ... Millepachine (MIL), a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against many human cancer cells both in vitro and in vivo. In this study, we found that MIL significantly inhibited the proliferation of cisplatin‐resistant A2780CP cells via inducing obvious G2/M arrest and apoptosis and down‐regulating the activity of topois ...
- DOI:
- 10.1002/ptr.6180
- https://doi.org/10.1002/ptr.6180
- Author:
- Jing Chen; Ke Huang; Qijun Chen; Chao Deng; Jian Zhang; Zhiyuan Zhong
- Source:
- ACS applied materials & interfaces 2018 v.10 no.4 pp. 3929-3937
- ISSN:
- 1944-8252
- Subject:
- animal ovaries; antibodies; antineoplastic activity; biopharmaceuticals; chemistry; fluorescence; humans; hyaluronic acid; hyaluronoglucosaminidase; image analysis; immunoglobulin G; materials science; medicine; mice; ovarian neoplasms; therapeutics
- Abstract:
- ... Antibody therapeutics, though representing a most used biomedicine, suffers from poor in vivo stability, rapid degradation, and frequent injections. Here, we report that fluorescent hyaluronic acid microgels (HMGs) tailor-made by combining microfluidics and “tetrazole–alkene” photoclick chemistry enable sustained and localized delivery of Herceptin in ovarian tumors. HMGs were obtained with a defi ...
- DOI:
- 10.1021/acsami.7b15832
- https://doi.org/10.1021/acsami.7b15832
- Author:
- Qi Li; Xinglan An; Xiaxia Man; Meiran Chu; Tianchuang Zhao; Hao Yu; Ziyi Li
- Source:
- Life sciences 2019 v.239 pp. 116999
- ISSN:
- 0024-3205
- Subject:
- adverse effects; animal ovaries; antineoplastic activity; biosynthesis; blood serum; cholesterol; cyclophosphamide; enzyme-linked immunosorbent assay; eosin; estradiol; follicle-stimulating hormone; gene expression regulation; genes; intraperitoneal injection; mice; peroxisome proliferator-activated receptors; protein-protein interactions; quantitative polymerase chain reaction; sequence analysis; signal transduction; staining; toxicity; transcriptome; transcriptomics
- Abstract:
- ... The present study aimed to investigate the effects of cyclophosphamide (Cytoxan, CTX) on premature ovarian failure (POF) in mice and its regulatory mechanisms by transcriptome analysis.Female C57BL/6 mice were treated with a single intraperitoneal injection of 70 mg/kg CTX. Serum levels of estradiol (E₂) and follicle stimulating hormone (FSH) were measured by enzyme-linked immunosorbent assay (ELI ...
- DOI:
- 10.1016/j.lfs.2019.116999
- https://doi.org/10.1016/j.lfs.2019.116999
- Author:
- Xiaoyang Zhang; Yarong Liu; Yu Jeong Kim; John Mac; Rachel Zhuang; Pin Wang
- Source:
- RSC advances 2017 v.7 no.32 pp. 19685-19693
- ISSN:
- 2046-2069
- Subject:
- animal models; animal ovaries; antineoplastic activity; combination drug therapy; crosslinking; cytotoxicity; drugs; encapsulation; nanoparticles; neoplasm cells; ovarian neoplasms; paclitaxel; pharmacokinetics; stem cells; synergism
- Abstract:
- ... Carboplatin (CPT) and paclitaxel (PTX) used in combination is one of the most effective treatments for ovarian cancer. However, the traditional combination methods used to co-administrate CPT and PTX showed limited clinical efficacy due to their distinct pharmacokinetics. Although much effort has been devoted to developing nanoparticles capable of encapsulating drugs with different lipophilicites, ...
- DOI:
- 10.1039/c7ra01100h
- PubMed:
- 28603607
- PubMed Central:
- PMC5450007
- https://doi.org/10.1039/c7ra01100h
- Author:
- Pengyan Jiao; Jian Zhang; Yuguo Dong; Dongzhi Wei; Yuhong Ren
- Source:
- Applied microbiology and biotechnology 2018 v.102 no.22 pp. 9585-9594
- ISSN:
- 0175-7598
- Subject:
- adenine; animal ovaries; antineoplastic activity; catalytic activity; cell death; endoplasmic reticulum; enzymes; fluorescent antibody technique; in vitro studies; lung neoplasms; neoplasm cells; ovarian neoplasms; recombinant proteins; ribosomal RNA; ricin; therapeutics; toxicity; translation (genetics)
- Abstract:
- ... The specific targeting of immunotoxins enables their wide application in cancer therapy. The A-chain of the ricin protein (RTA) is an N-glycosidase that catalyzes the removal of adenine from the 28S rRNA, preventing protein translation and leading to cell death. Ricin is highly toxic but can only exert its toxic effects from within the cytoplasm. In this study, we linked the anti-HER2 single-chain ...
- DOI:
- 10.1007/s00253-018-9291-z
- https://doi.org/10.1007/s00253-018-9291-z
- Author:
- Guangya Xu; Bin Li; Ting Wang; Jun Wan; Yan Zhang; Jingwei Huang; Yangmei Shen
- Source:
- RSC advances 2018 v.8 no.38 pp. 21229-21242
- ISSN:
- 2046-2069
- Subject:
- animal models; animal ovaries; antineoplastic activity; apoptosis; bioavailability; cell growth; cytotoxicity; drug delivery systems; drugs; growth retardation; hydrogels; micelles; nanotechnology; ovarian neoplasms; particle size; quercetin; tissues; water solubility
- Abstract:
- ... Ovarian cancer, as one of the killers that threaten women’s health, has been studied extensively. As a natural bioflavonoid with prospective effects, quercetin is highly recognized for its anti-cancer applications. However, one of the major challenges that quercetin faces is its poor water solubility, instability in physiological media, and subsequent poor bioavailability. Thus, optimizing the ide ...
- DOI:
- 10.1039/c8ra03274b
- https://doi.org/10.1039/c8ra03274b
- Author:
- Duy Luong; Prashant Kesharwani; Hashem O. Alsaab; Samaresh Sau; Subhash Padhye; Fazlul H. Sarkar; Arun K. Iyer
- Source:
- Colloids and surfaces 2017 v.157 pp. 490-502
- ISSN:
- 0927-7765
- Subject:
- folate receptors; micelles; transcription factor NF-kappa B; uterine cervical neoplasms; drugs; colloids; antineoplastic activity; encapsulation; neoplasm cells; folic acid; hydrophobicity; solubility; composite polymers; curcumin; animal ovaries; apoptosis; ovarian neoplasms
- Abstract:
- ... The current study utilizes folic acid conjugated poly(styrene-co-maleic anhydride) block copolymer (FA-SMA) to enhance the solubility of a hydrophobic but very potent synthetic curcumin-difluorinated (CDF) analog and its targeted delivery to folate receptor-alpha overexpressing cancers. The nanomicelles showed high aqueous solubility. Importantly, the encapsulation of CDF in nanomicelles resulted ...
- DOI:
- 10.1016/j.colsurfb.2017.06.025
- PubMed:
- 28658642
- PubMed Central:
- PMC5560501
- https://doi.org/10.1016/j.colsurfb.2017.06.025
- Author:
- Minghua Zou; Changhua Xu; Hua Li; Xianquan Zhang; Weidong Fan
- Source:
- Archives of biochemistry and biophysics 2018 pp. -
- ISSN:
- 0003-9861
- Subject:
- animal ovaries; antineoplastic activity; caspase-3; cell lines; cell viability; cisplatin; drug therapy; gene expression; genes; hypoxia-inducible factor 1; metastasis; mice; neoplasm cells; ovarian neoplasms; phosphorylation; pro-apoptotic proteins; protein synthesis; signal transduction; vascular endothelial growth factors
- Abstract:
- ... This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause.The full Elsevier Policy on Article Withdrawal can be found at https://www.elsevier.com/about/our-business/policies/article-withdrawal ...
- DOI:
- 10.1016/j.abb.2018.07.002
- https://doi.org/10.1016/j.abb.2018.07.002
26. IL- 27 suppresses SKOV3 cells proliferation by enhancing STAT3 and inhibiting the Akt signal pathway
- Author:
- Zhu Zhang; Bin Zhou; Kui Zhang; Yaping Song; Lin Zhang; Mingrong Xi
- Source:
- Molecular Immunology 2016 v.78 pp. 155-163
- ISSN:
- 0161-5890
- Subject:
- Toll-like receptor 4; Western blotting; animal ovaries; antineoplastic activity; apoptosis; caspase-3; cell proliferation; cell viability; cytotoxicity; epithelium; genes; interferon-gamma; interleukin-12; interleukin-6; lactate dehydrogenase; messenger RNA; neoplasm cells; ovarian neoplasms; plasmids; signal transduction
- Abstract:
- ... Ovarian cancer continues to be the most lethal gynecologic malignancy worldwide. IL-27 is a novel member of the IL-12 cytokine family. The aim of this study was to investigate the effects of IL-27 on the ovarian cystadenocarcinoma cell line SKOV3 and determine possible mechanisms underlying its effect. We stably transfected an IL-27 plasmid, empty vector, IL-27 shRNA or negative control into SKOV3 ...
- DOI:
- 10.1016/j.molimm.2016.09.014
- https://doi.org/10.1016/j.molimm.2016.09.014
- Author:
- Bondì Maria Luisa; Emma Maria Rita; Botto Chiara; Augello Giuseppa; Azzolina Antonina; Di Gaudio Francesca; Craparo Emanuela Fabiola; Cavallaro Gennara; Bachvarov Dimcho; Cervello Melchiorre
- Source:
- Journal of agricultural and food chemistry 2017 v.65 no.7 pp. 1342-1352
- ISSN:
- 1520-5118
- Subject:
- animal ovaries; antineoplastic activity; bioavailability; cell growth; curcumin; drugs; human cell lines; in vitro studies; lipids; nanoparticles; ovarian neoplasms; solubility
- Abstract:
- ... Curcumin is a natural molecule with proved anticancer efficacy on several human cancer cell lines. However, its clinical application has been limited due to its poor bioavailability. Nanocarrier-based drug delivery approaches could make curcumin dispersible in aqueous media, thus overtaking the limits of its low solubility. The aim of this study was to increase the bioavailability and the antitumo ...
- DOI:
- 10.1021/acs.jafc.6b04409
- https://doi.org/10.1021/acs.jafc.6b04409
- Author:
- Mai F. Tolba; Hany A. Omar; Samar S. Azab; Amani E. Khalifa; Ashraf B. Abdel-Naim; Sherif Z. Abdel-Rahman
- Source:
- Critical reviews in food science and nutrition 2016 v.56 no.13 pp. 2183-2190
- ISSN:
- 1549-7852
- Subject:
- abscess; adverse effects; animal ovaries; antineoplastic activity; antioxidant activity; antioxidants; brain; caffeic acid; cisplatin; colon; doxorubicin; drug therapy; heart; honey bees; isoniazid; liver; methotrexate; mitomycin; propolis; protective effect; retina; skeletal muscle; streptomycin; testes; tissue repair; traditional medicine; vancomycin
- Abstract:
- ... Propolis, a honey bee product, has been used in folk medicine for centuries for the treatment of abscesses, canker sores and for wound healing. Caffeic acid phenethyl ester (CAPE) is one of the most extensively investigated active components of propolis which possess many biological activities, including antibacterial, antiviral, antioxidant, anti-inflammatory, and anti-cancer effects. CAPE is a p ...
- DOI:
- 10.1080/10408398.2013.821967
- https://doi.org/10.1080/10408398.2013.821967
- Author:
- Enitome E. Bafor; Jennifer McKenna; Edward G. Rowan; RuAngelie Edrada-Ebel
- Source:
- Natural product research 2017 v.31 no.18 pp. 2164-2168
- ISSN:
- 1478-6427
- Subject:
- inhibitory concentration 50; fatty acids; fractionation; nuclear magnetic resonance spectroscopy; methanol; antineoplastic activity; neoplasm cells; mass spectrometry; Ficus exasperata; animal ovaries; ovarian neoplasms
- Abstract:
- ... Ovarian cancer is one of the most common gynaecological cancers today. This study therefore investigates the anticancer effects of Ficus exasperata extracts and fractions on ovarian cancer cells. The antiproliferative activity of the crude extracts (1 mg/mL) was assessed using the MTT assay on A2780 (ovarian cancer) cell line. Bio-activity guided fractionation was performed and preliminary identif ...
- DOI:
- 10.1080/14786419.2016.1277348
- https://doi.org/10.1080/14786419.2016.1277348
- Author:
- Agnieszka Klupczynska; Anna Maria Sulej-Suchomska; Hanna Piotrowska-Kempisty; Marcin Wierzchowski; Jadwiga Jodynis-Liebert; Zenon J. Kokot
- Source:
- Journal of chromatography 2017 v.1060 pp. 30-35
- ISSN:
- 1570-0232
- Subject:
- acetonitrile; ammonium acetate; animal ovaries; antineoplastic activity; culture media; formic acid; high performance liquid chromatography; humans; metabolites; monitoring; neoplasm cells; ovarian neoplasms; resveratrol; solvents; spectrometers
- Abstract:
- ... The synthetic resveratrol analogue DMU-212 (3,4,4′,5-tetramethoxystilbene) has been shown to possess stronger anticancer activity than resveratrol in a variety of tumour cells. To date, there has been no appropriate procedure that would ensure a reliable data about levels of metabolic products of DMU-212 in cancer cell lines. The purpose of this study was to develop a new procedure for determinati ...
- DOI:
- 10.1016/j.jchromb.2017.05.015
- https://doi.org/10.1016/j.jchromb.2017.05.015
- Author:
- Wenjing He; Shuang Yu; Liantang Wang; Mian He; Xiaopei Cao; Yanbing Li; Haipeng Xiao
- Source:
- Molecular and Cellular Endocrinology 2016 v.436 pp. 240-249
- ISSN:
- 0303-7207
- Subject:
- agonists; animal ovaries; antineoplastic activity; apoptosis; glucagon-like peptide 1; humans; immunohistochemistry; islets of Langerhans; mice; neoplasm cells; ovarian neoplasms; patients; tissues
- Abstract:
- ... Glucagon-like peptide (GLP)-1 promotes proliferation and survival in β-cell; however, whether GLP-1 receptor agonists promote growth of human ovarian cancer cells remain unknown. We aimed to explore the effects of GLP-1 agents on ovarian cancer cells. GLP-1 receptor expression in human ovarian cancer tissues was detected by immunohistochemical analysis. The effects of exendin-4, a GLP-1R agonist, ...
- DOI:
- 10.1016/j.mce.2016.07.032
- https://doi.org/10.1016/j.mce.2016.07.032
32. Liriopesides B inhibited cell growth and decreased CA125 level in human ovarian cancer A2780 cells
- Author:
- Haiyan Wang; Haizhong Yu; Yonglin Sun; Huijun Zhao; Zhuang Guo; Bo Yu
- Source:
- Natural product research 2017 v.31 no.18 pp. 2198-2202
- ISSN:
- 1478-6427
- Subject:
- dose response; cell growth; humans; antineoplastic activity; animal ovaries; alkaline phosphatase; ovarian neoplasms
- Abstract:
- ... To study the effect of liriopesides B on cell growth curve, cell doubling time, the activity of tumour marker CA125 and alkaline phosphatase (AKP) in human ovarian cancer A2780 cells. Both cell growth curve and doubling time were studied by MTT assay, CA125 level and AKP activity were determined by respective kits. Results showed that liriopesides B could shift down the A2780 cells growth curve in ...
- DOI:
- 10.1080/14786419.2017.1320788
- https://doi.org/10.1080/14786419.2017.1320788
- Author:
- Yu Shan; Fuqin Guan; Xingzeng Zhao; Ming Wang; Yu Chen; Qizhi Wang; Xu Feng
- Source:
- Nutrition and cancer 2016 v.68 no.2 pp. 280-289
- ISSN:
- 1532-7914
- Subject:
- AMP-activated protein kinase; Lonicera; NAD ADP-ribosyltransferase; animal ovaries; antineoplastic activity; apoptosis; autophagy; cell proliferation; cysteine; cytotoxicity; growth retardation; humans; neoplasm cells; ovarian neoplasms; phosphorylation; reactive oxygen species; saponins
- Abstract:
- ... Macranthoside B (MB), a saponin compound in Lonicera macranthoides , can block cell proliferation and induce cell death in several types of cancer cells; however, the precise mechanisms by which MB exerts its anticancer effects remain poorly understood. MB blocked A2780 human ovarian carcinoma cell proliferation both dose- and time-dependently. MB induced apoptosis, with increased poly (ADP-ribose ...
- DOI:
- 10.1080/01635581.2016.1142587
- https://doi.org/10.1080/01635581.2016.1142587
- Author:
- Meran Keshawa Ediriweera; Kamani Hemamala Tennekoon; Achyut Adhikari; Sameera Ranganath Samarakoon; Ira Thabrew; E. Dilip de Silva
- Source:
- Journal of ethnopharmacology 2016 v.189 pp. 165-174
- ISSN:
- 0378-8741
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Ayurvedic medicine; Mangifera; animal ovaries; antineoplastic activity; antineoplastic agents; apoptosis; bark; breast neoplasms; breasts; caspase-3; catechin; cell cycle; cell lines; chloroform; cytotoxicity; drug therapy; epithelial cells; epithelium; estrogen receptors; gene expression; growth factors; high performance liquid chromatography; histone deacetylase; mammary glands; mass spectrometry; neoplasm cells; nuclear magnetic resonance spectroscopy; ovarian neoplasms; pharmacokinetics; quantitative polymerase chain reaction; quercetin; receptor protein-tyrosine kinase; Sri Lanka
- Abstract:
- ... Mangifera zeylanica Hook.f. (Anacardiaceae) is a plant endemic to Sri Lanka. Its bark has been used in traditional and Ayurvedic medicine for the treatment of various diseases including some cancers.This study was planned to isolate and identify potentially cytotoxic compounds from the bark of M. zeylanica, which may have contributed to its ethno pharmacological use in the treatment of cancer.The ...
- DOI:
- 10.1016/j.jep.2016.05.047
- https://doi.org/10.1016/j.jep.2016.05.047
- Author:
- Ezequiel Bernabeu; Lorena Gonzalez; Maximiliano Cagel; Esteban P. Gergic; Marcela A. Moretton; Diego A. Chiappetta
- Source:
- Colloids and surfaces 2016 v.140 pp. 403-411
- ISSN:
- 0927-7765
- Subject:
- animal ovaries; antineoplastic activity; apoptosis; breast neoplasms; colloids; composite polymers; cytotoxicity; dialysis; drug therapy; drugs; encapsulation; evaporation; humans; in vitro studies; light scattering; micelles; neoplasm cells; ovarian neoplasms; paclitaxel; polyethylene glycol; solubility; solvents; transmission electron microscopy
- Abstract:
- ... The aim of this work was to develop mixed micelles based on two biocompatible copolymers of polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol (Soluplus®) and D-α-tocopheryl polyethylene-glycol 1000 succinate (TPGS), to improve the aqueous solubility and the in vitro anti-tumor activity of paclitaxel (PTX). Pure and mixed nanomicelles were prepared by solvent evaporation method and charac ...
- DOI:
- 10.1016/j.colsurfb.2016.01.003
- https://doi.org/10.1016/j.colsurfb.2016.01.003
- Author:
- Jeon Mijin; Mishra Neeraj Kumar; De Umasankar; Sharma Satyasheel; Oh Yongguk; Choi Miji; Jo Hyeim; Sachan Richa; Kim Hyung Sik; Kim In Su
- Source:
- Journal of organic chemistry 2016 v.81 no.20 pp. 9878-9885
- ISSN:
- 1520-6904
- Subject:
- adenocarcinoma; animal ovaries; antineoplastic activity; carbon-hydrogen bond activation; cytotoxicity; doxorubicin; endometrium; humans; neoplasm cells; organic chemistry; ovarian neoplasms; rhodium; synthesis
- Abstract:
- ... The rhodium(III)-catalyzed direct C–H functionalization of various indolines with 1,4,2-dioxazol-5-ones as new amidating agents is described. This transformation provides efficient preparation of C7-amidated indolines known to display potent anticancer activity. The synthetic compounds were evaluated for in vitro anticancer activity against human prostate adenocarcinoma cells (LNCaP), human endome ...
- DOI:
- 10.1021/acs.joc.6b02020
- https://doi.org/10.1021/acs.joc.6b02020
- Author:
- Kyungjae Andrew Yoon; Kyungmun Kim; A-Young Kim; Young Han Park; Woo Young Bang; Changmu Kim; Joo-Hong Yeo; Young Ho Koh; Si Hyeock Lee
- Source:
- Journal of Asia-Pacific entomology 2016 v.19 no.3 pp. 821-828
- ISSN:
- 1226-8615
- Subject:
- Candida albicans; Vespa; animal ovaries; antineoplastic activity; chemotaxis; circular dichroism spectroscopy; complementary DNA; drug carriers; drugs; hemolysis; ovarian neoplasms; peptides; venoms
- Abstract:
- ... We identified vespid chemotactic peptide (VCP) and vespakinin (Vespk) from the lesser paper wasp, Parapolybia varia. The cDNA, genomic DNA, and mature peptide sequences of P. varia VCP (PvVCP) and Vespk (PvVespk) were determined. To investigate the pharmacological and toxicological properties of PvVCP and PvVespk, their hemolytic, anti-microbial, anti-fungal, and anti-tumor activities were evaluat ...
- DOI:
- 10.1016/j.aspen.2016.07.015
- https://doi.org/10.1016/j.aspen.2016.07.015
- Author:
- Huimin Li; Zhikun Lin; Yuxin Bai; Xinming Chi; Hailu Fu; Rui Sun; Meizi Liu; Xuan Liu; Liying Chen; Shujuan Shao
- Source:
- RSC advances 2017 v.7 no.79 pp. 50017-50026
- ISSN:
- 2046-2069
- Subject:
- Sinomenium acutum; Western blotting; animal ovaries; antineoplastic activity; beta catenin; cadherins; cell growth; cell proliferation; chemoprevention; dose response; epithelium; gene overexpression; medicinal plants; messenger RNA; metastasis; neoplasm cells; oncogenes; ovarian neoplasms; protein synthesis; signal transduction; sinomenine; vimentin
- Abstract:
- ... Sinomenine (SIN), an isoquinoline isolated from the Chinese medicinal plant Sinomenium acutum, is well known for its curative effect on rheumatic and arthritic diseases. Recently, SIN has been reported to possess potent anti-tumor effects in various types of cancers. However, the role and the underlying mechanism of the inhibitory action of SIN on ovarian cancer remain unknown. In this study, we p ...
- DOI:
- 10.1039/c7ra10057d
- https://doi.org/10.1039/c7ra10057d
- Author:
- Duy Luong; Prashant Kesharwani; Bryan A. Killinger; Anna Moszczynska; Fazlul H. Sarkar; Subhash Padhye; Arun K. Rishi; Arun K. Iyer
- Source:
- Journal of Colloid And Interface Science 2016 v.484 pp. 33-43
- ISSN:
- 0021-9797
- Subject:
- adverse effects; animal ovaries; antineoplastic activity; antineoplastic agents; apoptosis; drug therapy; flavonoids; folic acid; half life; hydrophobicity; ligands; neoplasm cells; ovarian neoplasms; solubility; transcription factor NF-kappa B; uterine cervical neoplasms
- Abstract:
- ... Conventional chemotherapy using small molecule drugs is marred by several challenges such as short half-life, low therapeutic index and adverse systemic side effects. In this regard, targeted therapies using ligand directed polyamidoamine (PAMAM) dendrimers could be a promising strategy to specifically deliver anticancer drugs to cancer cells overexpressing complementary receptor binding domains. ...
- DOI:
- 10.1016/j.jcis.2016.08.061
- https://doi.org/10.1016/j.jcis.2016.08.061
- Author:
- Jing Xu; Dan Chen; Chang Liu; Xiong-Zhi Wu; Cai-Xia Dong; Jing Zhou
- Source:
- International journal of biological macromolecules 2016 v.82 pp. 765-771
- ISSN:
- 0141-8130
- Subject:
- Atractylodes lancea; Fourier transform infrared spectroscopy; animal ovaries; antineoplastic activity; cell proliferation; derivatization; fructans; fructose; gas chromatography-mass spectrometry; glucose; hepatoma; high performance liquid chromatography; human cell lines; liver; molecular weight; neoplasm cells; nuclear magnetic resonance spectroscopy; ovarian neoplasms; polymerization; rhizomes; uterine cervical neoplasms
- Abstract:
- ... A fructan (ACPS-1) with a molecular weight of 11.2kDa was isolated from Atractylodes chinensis rhizome and characterized by chemical derivatization, HPLC, GC–MS, FT-IR, and NMR. Structural analyses revealed that ACPS-1 is predominately composed of fructose and a small amount of glucose and a polymerization degree of about 53. The fructan was deduced to be an inulin-type fructan containing a linear ...
- DOI:
- 10.1016/j.ijbiomac.2015.10.082
- https://doi.org/10.1016/j.ijbiomac.2015.10.082
- Author:
- Maria Russo; Gian Luigi Russo; Maria Daglia; Pandima Devi Kasi; Sakthivel Ravi; Seyed Fazel Nabavi; Seyed Mohammad Nabavi
- Source:
- Food chemistry 2016 v.196 pp. 589-600
- ISSN:
- 0308-8146
- Subject:
- adjuvants; adverse effects; animal ovaries; antineoplastic activity; bladder; brain; breast neoplasms; cell proliferation; chemoprevention; chronic diseases; colon; colorectal neoplasms; dietary supplements; genistein; liver; lymphocytic leukemia; ovarian neoplasms; prostatic neoplasms; soybeans; stomach neoplasms
- Abstract:
- ... Nowadays, diet and specific dietary supplements are seen as potential adjuvants to prevent different chronic diseases, including cancer, or to ameliorate pharmacological therapies. Soybean is one of the most important food components in Asian diet. A plethora of evidence supports the in vitro and in vivo anticancer effects of genistein, a soybean isoflavone. Major tumors affected by genistein here ...
- DOI:
- 10.1016/j.foodchem.2015.09.085
- https://doi.org/10.1016/j.foodchem.2015.09.085
- Author:
- Kirkpatrick Christine L.; Broberg Christopher A.; McCool Elijah N.; Lee Woo Jean; Chao Alex; McConnell Evan W.; Pritchard David A.; Hebert Michael; Fleeman Renee; Adams Jessie; Jamil Amer; Madera Laurence; Strömstedt Adam A.; Göransson Ulf; Liu Yufeng; Hoskin David W.; Shaw Lindsey N.; Hicks Leslie M.
- Source:
- Analytical chemistry 2017 v.89 no.2 pp. 1194-1201
- ISSN:
- 1520-6882
- Subject:
- Viola odorata; animal ovaries; antibacterial properties; antibiotics; antineoplastic activity; cytotoxicity; drug resistance; mass spectrometry; mechanism of action; morbidity; mortality; oxygen; pathogens; peptides; prostatic neoplasms; statistics
- Abstract:
- ... The recent increase in extensively drug-resistant bacterial pathogens and the associated increase of morbidity and mortality demonstrate the immediate need for new antibiotic backbones with novel mechanisms of action. Here, we report the development of the PepSAVI-MS pipeline for bioactive peptide discovery. This highly versatile platform employs mass spectrometry and statistics to identify bioact ...
- DOI:
- 10.1021/acs.analchem.6b03625
- https://doi.org/10.1021/acs.analchem.6b03625
- Author:
- Tze-Chien Chen; Chih-Chiang Chien; Ming-Shun Wu; Yen-Chou Chen
- Source:
- Phytomedicine 2016 v.23 no.1 pp. 68-78
- ISSN:
- 0944-7113
- Subject:
- DNA; DNA fragmentation; Euodia; Western blotting; adenosine diphosphate; animal ovaries; antineoplastic activity; apoptosis; caspase-3; cell viability; drug therapy; herbal medicines; humans; membrane potential; mitochondrial membrane; mitogen-activated protein kinase; neoplasm cells; ovarian neoplasms; proteins; signal transduction; staining; structure-activity relationships
- Abstract:
- ... Evodiamine (EVO; 8,13,13b,14-tetrahydro-14-methylindolo[2′3′-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one derived from the traditional herbal medicine Evodia rutaecarpa was reported to possess anticancer activity; however, the anticancer mechanism of EVO against the viability of human ovarian cancer cells is still unclear.A number of studies showed that chemotherapeutic benefits may result from targetin ...
- DOI:
- 10.1016/j.phymed.2015.12.003
- https://doi.org/10.1016/j.phymed.2015.12.003
- Author:
- Lei WangCo-first author.; Weimin Wu; Jingshuai Wang; Jianjun Wang; Xiaowen Tong; Qiaoling Hu; Lifeng Qi
- Source:
- Journal of materials chemistry B 2015 v.4 no.2 pp. 273-281
- ISSN:
- 2050-7518
- Subject:
- RNA interference; animal ovaries; antineoplastic activity; apoptosis; cadherins; composite polymers; cytotoxicity; gene overexpression; genes; morbidity; mortality; nanocarriers; nanoparticles; neoplasm cells; ovarian neoplasms; patients; phosphatidylinositol 3-kinase; quality of life; small interfering RNA
- Abstract:
- ... Malignant bowel obstruction (MBO) is a serious complication which causes high death rate and low quality of life (QOL) for patients diagnosed at an advanced stage of ovarian cancer. RNA interference (RNAi) could be a promising method for the treatment of ovarian cancer and could decrease the morbidity of MBO. Gab2 gene is overexpressed in ovarian cancer compared with normal ovarian tissue, and reg ...
- DOI:
- 10.1039/c5tb01238d
- https://doi.org/10.1039/c5tb01238d
- Author:
- Suhong Xie; Hui Zheng; Xuemei Wen; Jiajun Sun; Yanchun Wang; Xiang Gao; Lin Guo; Renquan Lu
- Source:
- Biochemical and biophysical research communications 2016 v.476 pp. 493-500
- ISSN:
- 0006-291X
- Subject:
- DNA repair; animal ovaries; antineoplastic activity; biopsy; carcinogenesis; cell cycle; cell proliferation; cell senescence; cisplatin; drug resistance; epithelial cells; growth and development; humans; immunohistochemistry; neoplasm cells; ovarian development; ovarian neoplasms; patients; photosensitivity disorders; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction
- Abstract:
- ... The dysfunction of DNA damage repair (DDR) pathway contributes to tumorigenesis and drug-resistance in cancer. MUS81 is a member of the conserved xeroderma pigmentosum group F (XPF) family protein of endonucleases, which is important to the DDR pathway. However, the role of MUS81 in the development of ovarian cancer remains uncertain. To explore the expression of MUS81 and its association to serou ...
- DOI:
- 10.1016/j.bbrc.2016.05.152
- https://doi.org/10.1016/j.bbrc.2016.05.152
- Author:
- Quan V. Vuong; Sathira Hirun; Tiffany L.K. Chuen; Chloe D. Goldsmith; Benjamin Munro; Michael C. Bowyer; Anita C. Chalmers; Jennette A. Sakoff; Phoebe A. Phillips; Christopher J. Scarlett
- Source:
- Industrial crops and products 2015 v.64 pp. 167-174
- ISSN:
- 0926-6690
- Subject:
- Eucalyptus robusta; alpha-tocopherol; animal ovaries; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; brain; coasts; colon; drug therapy; essential oils; health promotion; leaf extracts; leaves; pancreatic neoplasms; phenolic compounds; spray drying; toxicity; trees; Australia
- Abstract:
- ... Eucalyptus robusta (Sm.) (ER) is a widely distributed tree native to the east coast of Australia, which has also been established in numerous other countries. ER leaves contain high levels of essential oils and are rich in total phenolic compounds (TPC), which have been linked with health benefits; however, there is limited information on the bioactivity of ER leaf extracts. This study aimed to op ...
- DOI:
- 10.1016/j.indcrop.2014.10.061
- https://doi.org/10.1016/j.indcrop.2014.10.061
- Author:
- Ludmila Yarmolinsky; Gabit Bari; Rachel Hamias; Hani Maor; Arie Budovsky; Marina Wolfson; Vadim Fraifeld; Michael Danilenko; Shimon Ben-Shabat
- Source:
- Israel journal of plant sciences 2015 v.62 no.4 pp. 229-233
- ISSN:
- 2223-8980
- Subject:
- Varthemia; animal ovaries; antineoplastic activity; chemotypes; cytotoxicity; flavonoids; humans; lung neoplasms; melanoma; myeloid leukemia; neoplasm cells; viability; Israel
- Abstract:
- ... The present study was aimed at investigating the anti-cancer properties of the unique chemotype of Varthemia iphionoides (V. iphionoides) growing in the Judaea region (Israel). Specifically, we determined the effects of the crude ethanolic extract of V. iphionoides on the growth and viability of human cancer cell lines (SKOV3 ovarian carcinoma cells, BG melanoma cells, A549 lung cancer cells, and ...
- DOI:
- 10.1080/07929978.2015.1027122
- https://doi.org/10.1080/07929978.2015.1027122
- Author:
- Abimbola Peter Oluyori; Arun Kumar Shaw; Gabriel Ademola Olatunji; Preeti Rastogi; Sanjeev Meena; Dipak Datta; Ashish Arora; Sammajay Reddy; Saidha Puli
- Source:
- Nutrition and cancer 2016 v.68 no.8 pp. 1330-1337
- ISSN:
- 1532-7914
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Ipomoea batatas; animal ovaries; antineoplastic activity; antioxidant activity; butanol; ethyl acetate; fractionation; gel chromatography; head; head and neck neoplasms; hexane; inhibitory concentration 50; mass spectrometry; neck; nuclear magnetic resonance spectroscopy; ovarian neoplasms; plant residues; silica gel; sweet potatoes
- Abstract:
- ... A bioassay-guided fractionation of an alcoholic extract from the peels of Ipomoea batatas Lam has been carried out. Sulforhodamine B and 2,2-diphenyl-1-picrylhydrazyl (DPPH) assays were used to evaluate the anticancer and antioxidant potential, respectively, while silica gel column chromatography (CC) was used to isolate compounds that were characterized using 1D- and 2D-NMR (Nuclear Magnetic Reso ...
- DOI:
- 10.1080/01635581.2016.1225107
- https://doi.org/10.1080/01635581.2016.1225107
- Author:
- Jyun-Yi Lin; Yu-Min Ke; Jui-Sheng Lai; Tsing-Fen Ho
- Source:
- Phytomedicine 2015 v.22 pp. 929-938
- ISSN:
- 0944-7113
- Subject:
- Salvia miltiorrhiza; Western blotting; animal ovaries; antineoplastic activity; apoptosis; caspases; cytotoxicity; diterpenoids; gene expression regulation; gene overexpression; humans; mechanism of action; medicinal plants; messenger RNA; mitogen-activated protein kinase; models; neoplasm cells; ovarian neoplasms; pro-apoptotic proteins; protein synthesis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; transcription (genetics)
- Abstract:
- ... Tanshinone IIA (TIIA), a diterpene quinone from the medicinal plant Salvia miltiorrhiza Bunge (Lamiaceae) was shown to possess apoptotic and TRAIL-sensitizing effects. Still, the molecular mechanisms whereby TIIA induces apoptosis remain largely unknown.The role of survivin, an inhibitor of apoptosis protein, in TIIA-induced apoptosis has never been addressed before and hence was the primary goal ...
- DOI:
- 10.1016/j.phymed.2015.06.012
- https://doi.org/10.1016/j.phymed.2015.06.012
- Author:
- Seema Patel; Pratibha Gogna
- Source:
- Industrial crops and products 2015 v.76 pp. 1148-1163
- ISSN:
- 0926-6690
- Subject:
- acne; animal ovaries; antineoplastic activity; antioxidants; apoptosis; colorectal neoplasms; cosmetics; distillation; essential oils; health promotion; hypersensitivity; immunomodulation; ingredients; liver; migraine; monitoring; multiple drug resistance; nerve tissue; oils; pain; pancreas; pharyngitis; phenylpropanoids; pregnancy complications; risk; sleep disorders; supercritical fluid extraction; tendinitis; terpenoids; therapeutics
- Abstract:
- ... Essential oils are volatile fractions of plants, obtained by distillation or supercritical fluid extraction. Rich in terpenes and phenylpropanoids, these oils have demonstrated varied pharmacological properties. For their myriad health promoting attributes, they have become quintessential ingredients in cosmetics, toiletries and aromatherapy. They are used to relieve a plethora of disorders like s ...
- DOI:
- 10.1016/j.indcrop.2015.08.024
- https://doi.org/10.1016/j.indcrop.2015.08.024