You searched for:
Subject
animal ovaries
Remove constraint Subject: animal ovaries
Subject
antineoplastic activity
Remove constraint Subject: antineoplastic activity
PubAg
Main content area
Limit your search
- animal ovaries[remove]71
- antineoplastic activity[remove]71
- ovarian neoplasms61
- neoplasm cells48
- apoptosis33
- more Subject »
Search
71 Search Results
« Previous |
1 - 50 of 71
|
Next »
Search Results
1. IL- 27 suppresses SKOV3 cells proliferation by enhancing STAT3 and inhibiting the Akt signal pathway
- Author:
- Zhu Zhang; Bin Zhou; Kui Zhang; Yaping Song; Lin Zhang; Mingrong Xi
- Source:
- Molecular Immunology 2016 v.78 pp. 155-163
- ISSN:
- 0161-5890
- Subject:
- Toll-like receptor 4; Western blotting; animal ovaries; antineoplastic activity; apoptosis; caspase-3; cell proliferation; cell viability; cytotoxicity; epithelium; genes; interferon-gamma; interleukin-12; interleukin-6; lactate dehydrogenase; messenger RNA; neoplasm cells; ovarian neoplasms; plasmids; signal transduction
- Abstract:
- ... Ovarian cancer continues to be the most lethal gynecologic malignancy worldwide. IL-27 is a novel member of the IL-12 cytokine family. The aim of this study was to investigate the effects of IL-27 on the ovarian cystadenocarcinoma cell line SKOV3 and determine possible mechanisms underlying its effect. We stably transfected an IL-27 plasmid, empty vector, IL-27 shRNA or negative control into SKOV3 ...
- DOI:
- 10.1016/j.molimm.2016.09.014
- https://doi.org/10.1016/j.molimm.2016.09.014
- Author:
- Nana Bie; Lirong Han; Meng Meng; Yuanyuan Zhang; Mingzhu Guo; Chunling Wang
- Source:
- Journal of functional foods 2020 v.65 pp. 103739
- ISSN:
- 1756-4646
- Subject:
- T-lymphocytes; animal models; animal ovaries; antineoplastic activity; apoptosis; caspase-3; cell proliferation; cytochrome c; eicosapentaenoic acid; human diseases; immunomodulators; macrophages; mitogen-activated protein kinase; natural killer cells; neoplasm cells; ovarian neoplasms; phagocytosis; phosphatidylinositol 3-kinase; phosphorylation; rats; spleen; splenocytes; thymus gland; transcription factor NF-kappa B
- Abstract:
- ... Eicosapentaenoic acid (EPA) has been known to induce human ovarian cancer cells apoptosis in vitro. However, the anti-tumor mechanisms of EPA in vivo have been rarely reported. In this study, the effect of EPA on the ovarian cancer rat model and its related mechanism were investigated. The results showed after EPA treatment, the index of spleens and thymus was significantly increased, and the prol ...
- DOI:
- 10.1016/j.jff.2019.103739
- https://doi.org/10.1016/j.jff.2019.103739
- Author:
- Daniele Vergara; Pasquale Simeone; Simona Bettini; Andrea Tinelli; Ludovico Valli; Carlo Storelli; Silvana Leo; Angelo Santino; Michele Maffia
- Source:
- Food & function 2014 v.5 no.6 pp. 1261-1269
- ISSN:
- 2042-650X
- Subject:
- animal ovaries; anticarcinogenic activity; antineoplastic activity; ascites; bioactive compounds; breasts; cell adhesion; cell viability; curcumin; diterpenoids; drug therapy; drugs; epithelium; fibronectins; fruits; human cell lines; humans; intestines; metastasis; neoplasm cells; ovarian neoplasms; patients; phytochemicals; vegetables
- Abstract:
- ... Dietary phytochemicals found in vegetables and fruits consist of a wide variety of biologically active compounds with anti-carcinogenic activity. The aim of this study was to evaluate the antigrowth activity of carnosol, a dietary diterpene, as a single agent or in combination with other dietary phytochemicals or chemotherapeutic drugs against a panel of tumor cell lines. Carnosol decreased cell v ...
- DOI:
- 10.1039/c4fo00023d
- https://doi.org/10.1039/c4fo00023d
- Author:
- Bondì Maria Luisa; Emma Maria Rita; Botto Chiara; Augello Giuseppa; Azzolina Antonina; Di Gaudio Francesca; Craparo Emanuela Fabiola; Cavallaro Gennara; Bachvarov Dimcho; Cervello Melchiorre
- Source:
- Journal of agricultural and food chemistry 2017 v.65 no.7 pp. 1342-1352
- ISSN:
- 1520-5118
- Subject:
- animal ovaries; antineoplastic activity; bioavailability; cell growth; curcumin; drugs; human cell lines; in vitro studies; lipids; nanoparticles; ovarian neoplasms; solubility
- Abstract:
- ... Curcumin is a natural molecule with proved anticancer efficacy on several human cancer cell lines. However, its clinical application has been limited due to its poor bioavailability. Nanocarrier-based drug delivery approaches could make curcumin dispersible in aqueous media, thus overtaking the limits of its low solubility. The aim of this study was to increase the bioavailability and the antitumo ...
- DOI:
- 10.1021/acs.jafc.6b04409
- https://doi.org/10.1021/acs.jafc.6b04409
- Author:
- Mai F. Tolba; Hany A. Omar; Samar S. Azab; Amani E. Khalifa; Ashraf B. Abdel-Naim; Sherif Z. Abdel-Rahman
- Source:
- Critical reviews in food science and nutrition 2016 v.56 no.13 pp. 2183-2190
- ISSN:
- 1549-7852
- Subject:
- abscess; adverse effects; animal ovaries; antineoplastic activity; antioxidant activity; antioxidants; brain; caffeic acid; cisplatin; colon; doxorubicin; drug therapy; heart; honey bees; isoniazid; liver; methotrexate; mitomycin; propolis; protective effect; retina; skeletal muscle; streptomycin; testes; tissue repair; traditional medicine; vancomycin
- Abstract:
- ... Propolis, a honey bee product, has been used in folk medicine for centuries for the treatment of abscesses, canker sores and for wound healing. Caffeic acid phenethyl ester (CAPE) is one of the most extensively investigated active components of propolis which possess many biological activities, including antibacterial, antiviral, antioxidant, anti-inflammatory, and anti-cancer effects. CAPE is a p ...
- DOI:
- 10.1080/10408398.2013.821967
- https://doi.org/10.1080/10408398.2013.821967
- Author:
- Haiqin SongThe two authors contributed equally to this work.; Feifei Quan; Zhiqiang Yu; Minhua Zheng; Yan Ma; Haihua Xiao; Fang Ding
- Source:
- Journal of materials chemistry B 2019 v.7 no.3 pp. 433-442
- ISSN:
- 2050-7518
- Subject:
- adverse effects; animal ovaries; antineoplastic activity; cell lines; chemistry; cisplatin; cytotoxicity; drug resistance; endocytosis; in vivo studies; iron oxides; magnetic fields; nanocarriers; nanoparticles; neoplasm cells; ovarian neoplasms; platinum; toxicity testing; zeta potential
- Abstract:
- ... Platinum (Pt)-based drugs including cisplatin, carboplatin and oxaliplatin have been widely used as first-line anticancer regimens due to their excellent anticancer efficacy. However, the clinical application of these drugs is greatly limited due to their side effects and drug resistance. In this study, an antitumor drug delivery system based on carboplatin prodrug loading Fe₃O₄ nanoparticles (NPs ...
- DOI:
- 10.1039/c8tb02574f
- https://doi.org/10.1039/c8tb02574f
- Author:
- Enitome E. Bafor; Jennifer McKenna; Edward G. Rowan; RuAngelie Edrada-Ebel
- Source:
- Natural product research 2017 v.31 no.18 pp. 2164-2168
- ISSN:
- 1478-6427
- Subject:
- inhibitory concentration 50; fatty acids; fractionation; nuclear magnetic resonance spectroscopy; methanol; antineoplastic activity; neoplasm cells; mass spectrometry; Ficus exasperata; animal ovaries; ovarian neoplasms
- Abstract:
- ... Ovarian cancer is one of the most common gynaecological cancers today. This study therefore investigates the anticancer effects of Ficus exasperata extracts and fractions on ovarian cancer cells. The antiproliferative activity of the crude extracts (1 mg/mL) was assessed using the MTT assay on A2780 (ovarian cancer) cell line. Bio-activity guided fractionation was performed and preliminary identif ...
- DOI:
- 10.1080/14786419.2016.1277348
- https://doi.org/10.1080/14786419.2016.1277348
- Author:
- Prabhat Pratap Singh Tomar; Kumar Nikhil; Anamika Singh; Purushotham Selvakumar; Partha Roy; Ashwani Kumar Sharma
- Source:
- Biochemical and biophysical research communications 2014 v.448 pp. 349-354
- ISSN:
- 0006-291X
- Subject:
- DNA; DNA fragmentation; Fusarium oxysporum; acridine orange; albumins; animal ovaries; antifungal properties; antineoplastic activity; apoptosis; biotechnology; breast neoplasms; cytotoxicity; deoxyribonucleases; hepatoma; prostatic neoplasms; pumpkins; ribonucleases; staining; translation (genetics)
- Abstract:
- ... The plant 2S albumins exhibit a spectrum of biotechnologically exploitable functions. Among them, pumpkin 2S albumin has been shown to possess RNase and cell-free translational inhibitory activities. The present study investigated the anticancer, DNase and antifungal activities of pumpkin 2S albumin. The protein exhibited a strong anticancer activity toward breast cancer (MCF-7), ovarian teratocar ...
- DOI:
- 10.1016/j.bbrc.2014.04.158
- https://doi.org/10.1016/j.bbrc.2014.04.158
- Author:
- V.T. de Lima; M.C. Vieira; C.A.L. Kassuya; C.A.L. Cardoso; J.M. Alves; M.A. Foglio; J.E. de Carvalho; A.S.N. Formagio
- Source:
- Phytomedicine 2014 v.21 pp. 1298-1302
- ISSN:
- 0944-7113
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Ocimum kilimandscharicum; animal ovaries; anti-inflammatory activity; antineoplastic activity; antioxidant activity; camphor; carrageenan; chemical composition; cineole; cytotoxicity; essential oils; free radical scavengers; gas chromatography-mass spectrometry; humans; hydrodistillation; leaves; leukocytes; limonene; mice; oils; oral administration; ovarian neoplasms; pleurisy; screening
- Abstract:
- ... The essential oil from the leaves of Ocimum kilimandscharicum (EOOK), collected in Dourados-MS, was investigated for anticancer, anti-inflammatory and antioxidant activity and chemical composition.The essential oil was extracted by hydrodistillation, and the chemical composition was performed by gas chromatography–mass spectrometry. The essential oil was evaluated for free radical-scavenging activ ...
- DOI:
- 10.1016/j.phymed.2014.07.004
- https://doi.org/10.1016/j.phymed.2014.07.004
- Author:
- Xiaoyang Zhang; Yarong Liu; Yu Jeong Kim; John Mac; Rachel Zhuang; Pin Wang
- Source:
- RSC advances 2017 v.7 no.32 pp. 19685-19693
- ISSN:
- 2046-2069
- Subject:
- animal models; animal ovaries; antineoplastic activity; combination drug therapy; crosslinking; cytotoxicity; drugs; encapsulation; nanoparticles; neoplasm cells; ovarian neoplasms; paclitaxel; pharmacokinetics; stem cells; synergism
- Abstract:
- ... Carboplatin (CPT) and paclitaxel (PTX) used in combination is one of the most effective treatments for ovarian cancer. However, the traditional combination methods used to co-administrate CPT and PTX showed limited clinical efficacy due to their distinct pharmacokinetics. Although much effort has been devoted to developing nanoparticles capable of encapsulating drugs with different lipophilicites, ...
- DOI:
- 10.1039/c7ra01100h
- PubMed:
- 28603607
- PubMed Central:
- PMC5450007
- https://doi.org/10.1039/c7ra01100h
- Author:
- Min Ju Kim; So Jin Lee; Ju Hee Ryu; Sun Hwa Kim; Ick Chan Kwon; Thomas M. Roberts
- Source:
- Journal of controlled release 2020 v.318 pp. 98-108
- ISSN:
- 0168-3659
- Subject:
- allografting; animal ovaries; antineoplastic activity; apoptosis; carcinogenesis; cell proliferation; chitosan; drug development; drug resistance; enzyme inhibition; gene silencing; models; mutation; ovarian neoplasms; phosphatidylinositol 3-kinase; polymerization; signal transduction; small interfering RNA
- Abstract:
- ... The phosphoinositide 3-kinase (PI3K) and RAS signaling pathways are frequently co-activated and altered during oncogenesis. Owing to their regulatory cross-talk, the early attempts of targeting only one pathway have mostly ended up promoting the development of drug resistance. Here, we propose using small interfering RNA (siRNA) therapeutics to directly target the undruggable KRAS (siKRAS) in comb ...
- DOI:
- 10.1016/j.jconrel.2019.12.019
- PubMed:
- 31838203
- PubMed Central:
- PMC7056267
- https://doi.org/10.1016/j.jconrel.2019.12.019
- Author:
- Justyna Mikuła-Pietrasik; Anna Witucka; Martyna Pakuła; Paweł Uruski; Beata Begier-Krasińska; Arkadiusz Niklas; Andrzej Tykarski; Krzysztof Książek
- Source:
- Cellular and molecular life sciences 2019 v.76 no.4 pp. 681-697
- ISSN:
- 1420-682X
- Subject:
- DNA damage; angiogenesis; animal ovaries; antineoplastic activity; apoptosis; cell senescence; drug therapy; drugs; endothelial cells; epithelial cells; fibroblasts; metabolism; mitophagy; neurons; ovarian neoplasms; oxidative stress; somatic cells
- Abstract:
- ... One of the most neglected aspects of chemotherapy are changes, and possible consequences of these changes, that occur in normal somatic cells. In this review, we summarize effects of selected drugs used to treat ovarian cancer (platin derivatives—cisplatin and carboplatin; and taxanes—paclitaxel and docetaxel) on cellular metabolism, acquisition of reactive stroma features, cellular senescence, in ...
- DOI:
- 10.1007/s00018-018-2954-1
- PubMed:
- 30382284
- PubMed Central:
- PMC6514066
- https://doi.org/10.1007/s00018-018-2954-1
- Author:
- Pengyan Jiao; Jian Zhang; Yuguo Dong; Dongzhi Wei; Yuhong Ren
- Source:
- Applied microbiology and biotechnology 2018 v.102 no.22 pp. 9585-9594
- ISSN:
- 0175-7598
- Subject:
- adenine; animal ovaries; antineoplastic activity; catalytic activity; cell death; endoplasmic reticulum; enzymes; fluorescent antibody technique; in vitro studies; lung neoplasms; neoplasm cells; ovarian neoplasms; recombinant proteins; ribosomal RNA; ricin; therapeutics; toxicity; translation (genetics)
- Abstract:
- ... The specific targeting of immunotoxins enables their wide application in cancer therapy. The A-chain of the ricin protein (RTA) is an N-glycosidase that catalyzes the removal of adenine from the 28S rRNA, preventing protein translation and leading to cell death. Ricin is highly toxic but can only exert its toxic effects from within the cytoplasm. In this study, we linked the anti-HER2 single-chain ...
- DOI:
- 10.1007/s00253-018-9291-z
- https://doi.org/10.1007/s00253-018-9291-z
- Author:
- Eunbi Jo; Hyun-Jin Jang; Kyeong Eun Yang; Min Su Jang; Yang Hoon Huh; Hwa-Seung Yoo; Jun Soo Park; Ik-Soon Jang; Soo Jung Park
- Source:
- BMC complementary medicine and therapies 2020 v.20 no.1 pp. 1
- ISSN:
- 2662-7671
- Subject:
- B-cell lymphoma; Cordyceps militaris; animal ovaries; antineoplastic activity; apoptosis; caspases; cell proliferation; cell viability; cytosol; dose response; immunoblotting; immunocytochemistry; interleukin-1beta; mechanism of action; microarray technology; neoplasm cells; ovarian neoplasms; phosphorylation; transcription factor NF-kappa B; transmission electron microscopy; tumor necrosis factor receptors; tumor necrosis factor-alpha
- Abstract:
- ... BACKGROUND: Cordyceps militaris (L.) Fr. (C. militaris) exhibits pharmacological activities, including antitumor properties, through the regulation of the nuclear factor kappa B (NF-κB) signaling. Tumor Necrosis Factor (TNF) and TNF-α modulates cell survival and apoptosis through NF- κB signaling. However, the mechanism underlying its mode of action on the NF-κB pathway is unclear. METHODS: Here, ...
- DOI:
- 10.1186/s12906-019-2780-5
- PubMed:
- 32020859
- PubMed Central:
- PMC7076896
- https://doi.org/10.1186/s12906-019-2780-5
- Author:
- Yingxin Pang; Manfei Si; Bin Sun; Leilei Niu; Xia Xu; Tao Lu; Huiqing Yuan; Hongxiang Lou
- Source:
- Food and chemical toxicology 2014 v.69 pp. 163-174
- ISSN:
- 0278-6915
- Subject:
- animal ovaries; antineoplastic activity; apoptosis; autophagy; drugs; mice; neoplasm cells; organelles; ovarian neoplasms; toxicology
- Abstract:
- ... The analysis of dihydroptychantol (DHA) and its chemically synthesized macrocyclic bisbibenzyl derivatives (DHA1, 2 and 3) led to the selection of DHA2 as a potential drug candidate for ovarian cancer. The exposure of ovarian cancer SKOV3 cells to DHA2 resulted in the downregulation of the anti-apoptotic X-linked inhibitor of apoptosis protein (XIAP) and Bcl-2 and led to caspase-independent cell d ...
- DOI:
- 10.1016/j.fct.2014.04.010
- https://doi.org/10.1016/j.fct.2014.04.010
- Author:
- Agnieszka Klupczynska; Anna Maria Sulej-Suchomska; Hanna Piotrowska-Kempisty; Marcin Wierzchowski; Jadwiga Jodynis-Liebert; Zenon J. Kokot
- Source:
- Journal of chromatography 2017 v.1060 pp. 30-35
- ISSN:
- 1570-0232
- Subject:
- acetonitrile; ammonium acetate; animal ovaries; antineoplastic activity; culture media; formic acid; high performance liquid chromatography; humans; metabolites; monitoring; neoplasm cells; ovarian neoplasms; resveratrol; solvents; spectrometers
- Abstract:
- ... The synthetic resveratrol analogue DMU-212 (3,4,4′,5-tetramethoxystilbene) has been shown to possess stronger anticancer activity than resveratrol in a variety of tumour cells. To date, there has been no appropriate procedure that would ensure a reliable data about levels of metabolic products of DMU-212 in cancer cell lines. The purpose of this study was to develop a new procedure for determinati ...
- DOI:
- 10.1016/j.jchromb.2017.05.015
- https://doi.org/10.1016/j.jchromb.2017.05.015
- Author:
- Jingjing Li; Fan Tang; Renkai Li; Zhejie Chen; Simon Ming-Yuen Lee; Chaomei Fu; Jinming Zhang; George Pak-Heng Leung
- Source:
- Journal of nutritional biochemistry 2020 v.77 pp. 108268
- ISSN:
- 0955-2863
- Subject:
- Danio rerio; angiogenesis; animal ovaries; antineoplastic activity; apoptosis; bioactive compounds; blood vessels; caspase-3; caspase-9; cell cycle checkpoints; cyclins; ex vivo studies; glycyrrhetinic acid; human umbilical vein endothelial cells; in vitro studies; in vivo studies; interphase; licorice; mechanism of action; membrane potential; mice; mitochondrial membrane; mitogen-activated protein kinase; models; neoplasm cells; ovarian neoplasms; phosphorylation; pro-apoptotic proteins; rats; receptors; signal transduction; vascular endothelial growth factor receptor-2
- Abstract:
- ... Glycyrrhetinic acid (GA) is a major bioactive compound of licorice. The objective of this study was to investigate the effects of GA on ovarian cancer, particularly those related to angiogenesis and apoptosis, and to elucidate the underlying mechanisms of action. In vitro studies showed that GA significantly inhibited proliferation, migration, invasion and tube formation in human umbilical vein en ...
- DOI:
- 10.1016/j.jnutbio.2019.108268
- https://doi.org/10.1016/j.jnutbio.2019.108268
- Author:
- Xue Feng; Ling Li; Hong Jiang; Keping Jiang; Ye Jin; Jianhua Zheng
- Source:
- Biochemical and biophysical research communications 2014 v.444 pp. 376-381
- ISSN:
- 0006-291X
- Subject:
- animal ovaries; antineoplastic activity; apoptosis; autophagy; cisplatin; drug therapy; humans; mechanism of action; neoplasm cells; ovarian neoplasms; phosphorylation
- Abstract:
- ... Dihydroartemisinin (DHA) exhibits anticancer activity in tumor cells but its mechanism of action is unclear. Cisplatin (DDP) is currently the best known chemotherapeutic available for ovarian cancer. However, tumors return de novo with acquired resistance over time. Mammalian target of rapamycin (mTOR) is an important kinase that regulates cell apoptosis and autophagy, and its dysregulation has be ...
- DOI:
- 10.1016/j.bbrc.2014.01.053
- https://doi.org/10.1016/j.bbrc.2014.01.053
- Author:
- Luis Varela-Rodríguez; Blanca Sánchez-Ramírez; Verónica Ivonne Hernández-Ramírez; Hugo Varela-Rodríguez; Rodrigo Daniel Castellanos-Mijangos; Carmen González-Horta; Bibiana Chávez-Munguía; Patricia Talamás-Rohana
- Source:
- BMC complementary medicine and therapies 2020 v.20 no.1 pp. 110
- ISSN:
- 2662-7671
- Subject:
- adenocarcinoma; alanine transaminase; analysis of variance; animal ovaries; antineoplastic activity; antineoplastic agents; apoptosis; carbonate dehydratase; cell cycle checkpoints; cell viability; chronic hepatitis; computer simulation; dimethyl sulfoxide; females; gallic acid; histopathology; in vitro studies; in vivo studies; intravenous injection; leukocytes; liver; mice; models; mortality; myricetin; nuclear magnetic resonance spectroscopy; ovarian neoplasms; paclitaxel; parenchyma (animal tissue); phosphatidylinositol 3-kinase; platinum; resection; taxanes; toxicology; transmission electron microscopy; urea
- Abstract:
- ... BACKGROUND: Ovarian cancer is the leading cause of mortality among malignant gynecological tumors. Surgical resection and chemotherapy with intravenous platinum/taxanes drugs are the treatments of choice, with little effectiveness in later stages and severe toxicological effects. Therefore, this study aimed to evaluate the antineoplastic activity of gallic acid (GA) and myricetin (Myr) administrat ...
- DOI:
- 10.1186/s12906-020-02900-z
- PubMed:
- 32276584
- PubMed Central:
- PMC7149887
- https://doi.org/10.1186/s12906-020-02900-z
- Author:
- Guangya Xu; Bin Li; Ting Wang; Jun Wan; Yan Zhang; Jingwei Huang; Yangmei Shen
- Source:
- RSC advances 2018 v.8 no.38 pp. 21229-21242
- ISSN:
- 2046-2069
- Subject:
- animal models; animal ovaries; antineoplastic activity; apoptosis; bioavailability; cell growth; cytotoxicity; drug delivery systems; drugs; growth retardation; hydrogels; micelles; nanotechnology; ovarian neoplasms; particle size; quercetin; tissues; water solubility
- Abstract:
- ... Ovarian cancer, as one of the killers that threaten women’s health, has been studied extensively. As a natural bioflavonoid with prospective effects, quercetin is highly recognized for its anti-cancer applications. However, one of the major challenges that quercetin faces is its poor water solubility, instability in physiological media, and subsequent poor bioavailability. Thus, optimizing the ide ...
- DOI:
- 10.1039/c8ra03274b
- https://doi.org/10.1039/c8ra03274b
- Author:
- Tze-Chien Chen; Chih-Chiang Chien; Ming-Shun Wu; Yen-Chou Chen
- Source:
- Phytomedicine 2016 v.23 no.1 pp. 68-78
- ISSN:
- 0944-7113
- Subject:
- DNA; DNA fragmentation; Euodia; Western blotting; adenosine diphosphate; animal ovaries; antineoplastic activity; apoptosis; caspase-3; cell viability; drug therapy; herbal medicines; humans; membrane potential; mitochondrial membrane; mitogen-activated protein kinase; neoplasm cells; ovarian neoplasms; proteins; signal transduction; staining; structure-activity relationships
- Abstract:
- ... Evodiamine (EVO; 8,13,13b,14-tetrahydro-14-methylindolo[2′3′-3,4]pyrido[2,1-b]quinazolin-5-[7H]-one derived from the traditional herbal medicine Evodia rutaecarpa was reported to possess anticancer activity; however, the anticancer mechanism of EVO against the viability of human ovarian cancer cells is still unclear.A number of studies showed that chemotherapeutic benefits may result from targetin ...
- DOI:
- 10.1016/j.phymed.2015.12.003
- https://doi.org/10.1016/j.phymed.2015.12.003
- Author:
- Wenjing He; Shuang Yu; Liantang Wang; Mian He; Xiaopei Cao; Yanbing Li; Haipeng Xiao
- Source:
- Molecular and Cellular Endocrinology 2016 v.436 pp. 240-249
- ISSN:
- 0303-7207
- Subject:
- agonists; animal ovaries; antineoplastic activity; apoptosis; glucagon-like peptide 1; humans; immunohistochemistry; islets of Langerhans; mice; neoplasm cells; ovarian neoplasms; patients; tissues
- Abstract:
- ... Glucagon-like peptide (GLP)-1 promotes proliferation and survival in β-cell; however, whether GLP-1 receptor agonists promote growth of human ovarian cancer cells remain unknown. We aimed to explore the effects of GLP-1 agents on ovarian cancer cells. GLP-1 receptor expression in human ovarian cancer tissues was detected by immunohistochemical analysis. The effects of exendin-4, a GLP-1R agonist, ...
- DOI:
- 10.1016/j.mce.2016.07.032
- https://doi.org/10.1016/j.mce.2016.07.032
- Author:
- Duy Luong; Prashant Kesharwani; Hashem O. Alsaab; Samaresh Sau; Subhash Padhye; Fazlul H. Sarkar; Arun K. Iyer
- Source:
- Colloids and surfaces 2017 v.157 pp. 490-502
- ISSN:
- 0927-7765
- Subject:
- folate receptors; micelles; transcription factor NF-kappa B; uterine cervical neoplasms; drugs; colloids; antineoplastic activity; encapsulation; neoplasm cells; folic acid; hydrophobicity; solubility; composite polymers; curcumin; animal ovaries; apoptosis; ovarian neoplasms
- Abstract:
- ... The current study utilizes folic acid conjugated poly(styrene-co-maleic anhydride) block copolymer (FA-SMA) to enhance the solubility of a hydrophobic but very potent synthetic curcumin-difluorinated (CDF) analog and its targeted delivery to folate receptor-alpha overexpressing cancers. The nanomicelles showed high aqueous solubility. Importantly, the encapsulation of CDF in nanomicelles resulted ...
- DOI:
- 10.1016/j.colsurfb.2017.06.025
- PubMed:
- 28658642
- PubMed Central:
- PMC5560501
- https://doi.org/10.1016/j.colsurfb.2017.06.025
- Author:
- Doori Park; Je Won Jung; Mi Ok Lee; Si Young Lee; Boyun Kim; Hye Jun Jin; Jiyoung Kim; Young-Joon Ahn; Ki Won Lee; Yong Sang Song; Seunghun Hong; James E. Womack; Hyung Wook Kwon
- Source:
- Peptides 2014 v.53 pp. 185-193
- ISSN:
- 0196-9781
- Subject:
- Apis cerana; Apis mellifera; Escherichia coli; animal ovaries; antimicrobial peptides; antimicrobial properties; antineoplastic activity; asparagine; bee venoms; carbon; cytotoxicity; gene frequency; genes; honey bees; human cell lines; humans; interleukin-6; melittin; neoplasm cells; ovarian neoplasms; serine; single nucleotide polymorphism; therapeutics; transistors; tumor necrosis factor-alpha
- Abstract:
- ... Insect-derived antimicrobial peptides (AMPs) have diverse effects on antimicrobial properties and pharmacological activities such as anti-inflammation and anticancer properties. Naturally occurring genetic polymorphism have a direct and/or indirect influence on pharmacological effect of AMPs, therefore information on single nucleotide polymorphism (SNP) occurring in natural AMPs provides an import ...
- DOI:
- 10.1016/j.peptides.2014.01.026
- https://doi.org/10.1016/j.peptides.2014.01.026
- Author:
- Lei WangCo-first author.; Weimin Wu; Jingshuai Wang; Jianjun Wang; Xiaowen Tong; Qiaoling Hu; Lifeng Qi
- Source:
- Journal of materials chemistry B 2015 v.4 no.2 pp. 273-281
- ISSN:
- 2050-7518
- Subject:
- RNA interference; animal ovaries; antineoplastic activity; apoptosis; cadherins; composite polymers; cytotoxicity; gene overexpression; genes; morbidity; mortality; nanocarriers; nanoparticles; neoplasm cells; ovarian neoplasms; patients; phosphatidylinositol 3-kinase; quality of life; small interfering RNA
- Abstract:
- ... Malignant bowel obstruction (MBO) is a serious complication which causes high death rate and low quality of life (QOL) for patients diagnosed at an advanced stage of ovarian cancer. RNA interference (RNAi) could be a promising method for the treatment of ovarian cancer and could decrease the morbidity of MBO. Gab2 gene is overexpressed in ovarian cancer compared with normal ovarian tissue, and reg ...
- DOI:
- 10.1039/c5tb01238d
- https://doi.org/10.1039/c5tb01238d
- Author:
- Rochelle R. Arvizo; Sounik Saha; Enfeng Wang; J. David Robertson; Resham Bhattacharya; Priyabrata Mukherjee
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.17 pp. 6700-6705
- ISSN:
- 0027-8424
- Subject:
- Western blotting; animal ovaries; antineoplastic activity; cadherins; growth factors; metastasis; mitogen-activated protein kinase; models; nanogold; nanoparticles; neoplasm cells; ovarian neoplasms; secretion; tissues; vimentin
- Abstract:
- ... Although biomedical applications of nanotechnology, which typically involve functionalized nanoparticles, have taken significant strides, biological characterization of unmodified nanoparticles remains underinvestigated. Herein we demonstrate that unmodified gold nanoparticles (AuNPs) inhibit the proliferation of cancer cells in a size- and concentration-dependent manner by abrogating MAPK-signali ...
- DOI:
- 10.1073/pnas.1214547110
- PubMed:
- 23569259
- PubMed Central:
- PMC3637766
- https://doi.org/10.1073/pnas.1214547110
- Author:
- Jinsha Koroth; Snehal Nirgude; Shweta Tiwari; Vidya Gopalakrishnan; Raghunandan Mahadeva; Sujeet Kumar; Subhas S. Karki; Bibha Choudhary
- Source:
- BMC complementary and alternative medicine 2019 v.19 no.1 pp. 273
- ISSN:
- 1472-6882
- Subject:
- Western blotting; adverse effects; alternative medicine; animal ovaries; antineoplastic activity; apoptosis; bioavailability; breast neoplasms; cell lines; cell movement; curcumin; cytotoxicity; flow cytometry; interstitial collagenase; liquids; metastasis; neoplasm cells; ovarian neoplasms; stem cells; toxicity testing
- Abstract:
- ... BACKGROUND: Curcumin is known for its multitude of medicinal properties, including anti-cancer and migrastatic activity. Efforts to overcome poor bioavailability, stability, and side effects associated with the higher dose of curcumin has led to the development of newer derivatives of curcumin. Thus, the focus of this study is to screen novel curcumin derivatives, namely ST03 and ST08, which have ...
- DOI:
- 10.1186/s12906-019-2685-3
- PubMed:
- 31638975
- PubMed Central:
- PMC6802352
- https://doi.org/10.1186/s12906-019-2685-3
- Author:
- Jinju Lee; Young Jae Cho; Jeong-Won Lee; Hyung Jun Ahn
- Source:
- Journal of controlled release 2020 v.321 pp. 184-197
- ISSN:
- 0168-3659
- Subject:
- animal ovaries; antineoplastic activity; antineoplastic agents; drug resistance; drug synergism; induced resistance; kinesin; microtubules; models; neoplasm cells; ovarian neoplasms; paclitaxel; small interfering RNA; therapeutics
- Abstract:
- ... Despite the promising anticancer effects of kinesin spindle protein (KSP) inhibition, functional plasticity of kinesins induced resistance against KSP inhibitors in a variety of cancers, leading to clinical failure. Additionally, paclitaxel is a widely used anticancer agent, but drug resistance has limited its use in the recurrent cancers. To overcome resistance against KSP inhibitors, we paired K ...
- DOI:
- 10.1016/j.jconrel.2020.02.013
- https://doi.org/10.1016/j.jconrel.2020.02.013
29. Liriopesides B inhibited cell growth and decreased CA125 level in human ovarian cancer A2780 cells
- Author:
- Haiyan Wang; Haizhong Yu; Yonglin Sun; Huijun Zhao; Zhuang Guo; Bo Yu
- Source:
- Natural product research 2017 v.31 no.18 pp. 2198-2202
- ISSN:
- 1478-6427
- Subject:
- dose response; cell growth; humans; antineoplastic activity; animal ovaries; alkaline phosphatase; ovarian neoplasms
- Abstract:
- ... To study the effect of liriopesides B on cell growth curve, cell doubling time, the activity of tumour marker CA125 and alkaline phosphatase (AKP) in human ovarian cancer A2780 cells. Both cell growth curve and doubling time were studied by MTT assay, CA125 level and AKP activity were determined by respective kits. Results showed that liriopesides B could shift down the A2780 cells growth curve in ...
- DOI:
- 10.1080/14786419.2017.1320788
- https://doi.org/10.1080/14786419.2017.1320788
- Author:
- Suhong Xie; Hui Zheng; Xuemei Wen; Jiajun Sun; Yanchun Wang; Xiang Gao; Lin Guo; Renquan Lu
- Source:
- Biochemical and biophysical research communications 2016 v.476 pp. 493-500
- ISSN:
- 0006-291X
- Subject:
- DNA repair; animal ovaries; antineoplastic activity; biopsy; carcinogenesis; cell cycle; cell proliferation; cell senescence; cisplatin; drug resistance; epithelial cells; growth and development; humans; immunohistochemistry; neoplasm cells; ovarian development; ovarian neoplasms; patients; photosensitivity disorders; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction
- Abstract:
- ... The dysfunction of DNA damage repair (DDR) pathway contributes to tumorigenesis and drug-resistance in cancer. MUS81 is a member of the conserved xeroderma pigmentosum group F (XPF) family protein of endonucleases, which is important to the DDR pathway. However, the role of MUS81 in the development of ovarian cancer remains uncertain. To explore the expression of MUS81 and its association to serou ...
- DOI:
- 10.1016/j.bbrc.2016.05.152
- https://doi.org/10.1016/j.bbrc.2016.05.152
- Author:
- Yu Shan; Fuqin Guan; Xingzeng Zhao; Ming Wang; Yu Chen; Qizhi Wang; Xu Feng
- Source:
- Nutrition and cancer 2016 v.68 no.2 pp. 280-289
- ISSN:
- 1532-7914
- Subject:
- AMP-activated protein kinase; Lonicera; NAD ADP-ribosyltransferase; animal ovaries; antineoplastic activity; apoptosis; autophagy; cell proliferation; cysteine; cytotoxicity; growth retardation; humans; neoplasm cells; ovarian neoplasms; phosphorylation; reactive oxygen species; saponins
- Abstract:
- ... Macranthoside B (MB), a saponin compound in Lonicera macranthoides , can block cell proliferation and induce cell death in several types of cancer cells; however, the precise mechanisms by which MB exerts its anticancer effects remain poorly understood. MB blocked A2780 human ovarian carcinoma cell proliferation both dose- and time-dependently. MB induced apoptosis, with increased poly (ADP-ribose ...
- DOI:
- 10.1080/01635581.2016.1142587
- https://doi.org/10.1080/01635581.2016.1142587
- Author:
- Sabrina Riedl; Dagmar Zweytick; Karl Lohner
- Source:
- Chemistry and physics of lipids 2011 v.164 no.8 pp. 766-781
- ISSN:
- 0009-3084
- Subject:
- animal ovaries; antineoplastic activity; antineoplastic agents; apoptosis; blood serum; cytotoxicity; drug resistance; drug therapy; heparan sulfate; in vivo studies; innate immunity; leukemia; markets; metastasis; microvilli; neoplasm cells; ovarian neoplasms; peptides; phosphatidylserines; plasma membrane; sialic acids; surface area
- Abstract:
- ... Although much progress has been achieved in the development of cancer therapies in recent decades, problems continue to arise particularly with respect to chemotherapy due to resistance to and low specificity of currently available drugs. Host defense peptides as effector molecules of innate immunity represent a novel strategy for the development of alternative anticancer drug molecules. These cat ...
- DOI:
- 10.1016/j.chemphyslip.2011.09.004
- PubMed:
- 21945565
- PubMed Central:
- PMC3220766
- https://doi.org/10.1016/j.chemphyslip.2011.09.004
- Author:
- Sha Xiao; Ming Zhang; Chang Liu; Deling Wang
- Source:
- Molecular genetics and genomics 2018 v.293 no.5 pp. 1159-1167
- ISSN:
- 1617-4615
- Subject:
- adenosine triphosphate; animal ovaries; antineoplastic activity; cisplatin; data collection; drug therapy; gene expression; luciferase; neoplasm cells; ovarian neoplasms; patients; prognosis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction
- Abstract:
- ... Cisplatin is one of the most popular chemotherapeutic drugs in treating ovarian cancer. Resistance to cisplatin is a common clinical challenge that needs to be solved to increase its anti-tumor effects. The relation of miR-514 expression with prognosis in ovarian cancer patients was analyzed based on GSE73584 datasets. The regulation of miR-514 on proliferation and cisplatin chemosensitivity of ov ...
- DOI:
- 10.1007/s00438-018-1447-0
- https://doi.org/10.1007/s00438-018-1447-0
- Author:
- Wenshuang Wu; Yang Liu; Haoyu Ye; Zhihui Li
- Source:
- Phytotherapy research 2018 v.32 no.12 pp. 2428-2435
- ISSN:
- 0951-418X
- Subject:
- ABC transporters; DNA topoisomerase (ATP-hydrolysing); Millettia pachycarpa; animal ovaries; antineoplastic activity; apoptosis; chalcone; cisplatin; drug resistance; enzyme activity; herbal medicines; humans; mice; models; neoplasm cells; ovarian neoplasms; research and development
- Abstract:
- ... Millepachine (MIL), a bioactive natural chalcone from Chinese herbal medicine Millettia pachycarpa Benth, exhibits strong antitumor effects against many human cancer cells both in vitro and in vivo. In this study, we found that MIL significantly inhibited the proliferation of cisplatin‐resistant A2780CP cells via inducing obvious G2/M arrest and apoptosis and down‐regulating the activity of topois ...
- DOI:
- 10.1002/ptr.6180
- https://doi.org/10.1002/ptr.6180
- Author:
- Meran Keshawa Ediriweera; Kamani Hemamala Tennekoon; Achyut Adhikari; Sameera Ranganath Samarakoon; Ira Thabrew; E. Dilip de Silva
- Source:
- Journal of ethnopharmacology 2016 v.189 pp. 165-174
- ISSN:
- 0378-8741
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Ayurvedic medicine; Mangifera; animal ovaries; antineoplastic activity; antineoplastic agents; apoptosis; bark; breast neoplasms; breasts; caspase-3; catechin; cell cycle; cell lines; chloroform; cytotoxicity; drug therapy; epithelial cells; epithelium; estrogen receptors; gene expression; growth factors; high performance liquid chromatography; histone deacetylase; mammary glands; mass spectrometry; neoplasm cells; nuclear magnetic resonance spectroscopy; ovarian neoplasms; pharmacokinetics; quantitative polymerase chain reaction; quercetin; receptor protein-tyrosine kinase; Sri Lanka
- Abstract:
- ... Mangifera zeylanica Hook.f. (Anacardiaceae) is a plant endemic to Sri Lanka. Its bark has been used in traditional and Ayurvedic medicine for the treatment of various diseases including some cancers.This study was planned to isolate and identify potentially cytotoxic compounds from the bark of M. zeylanica, which may have contributed to its ethno pharmacological use in the treatment of cancer.The ...
- DOI:
- 10.1016/j.jep.2016.05.047
- https://doi.org/10.1016/j.jep.2016.05.047
- Author:
- Ezequiel Bernabeu; Lorena Gonzalez; Maximiliano Cagel; Esteban P. Gergic; Marcela A. Moretton; Diego A. Chiappetta
- Source:
- Colloids and surfaces 2016 v.140 pp. 403-411
- ISSN:
- 0927-7765
- Subject:
- animal ovaries; antineoplastic activity; apoptosis; breast neoplasms; colloids; composite polymers; cytotoxicity; dialysis; drug therapy; drugs; encapsulation; evaporation; humans; in vitro studies; light scattering; micelles; neoplasm cells; ovarian neoplasms; paclitaxel; polyethylene glycol; solubility; solvents; transmission electron microscopy
- Abstract:
- ... The aim of this work was to develop mixed micelles based on two biocompatible copolymers of polyvinyl caprolactam–polyvinyl acetate–polyethylene glycol (Soluplus®) and D-α-tocopheryl polyethylene-glycol 1000 succinate (TPGS), to improve the aqueous solubility and the in vitro anti-tumor activity of paclitaxel (PTX). Pure and mixed nanomicelles were prepared by solvent evaporation method and charac ...
- DOI:
- 10.1016/j.colsurfb.2016.01.003
- https://doi.org/10.1016/j.colsurfb.2016.01.003
- Author:
- Jing Huang; Lei Wang; Zhongyi Cong; Zohreh Amoozgar; Evgeny Kiner; Deyin Xing; Sandra Orsulic; Ursula Matulonis; Michael S. Goldberg
- Source:
- Biochemical and biophysical research communications 2015 v.463 pp. 551-556
- ISSN:
- 0006-291X
- Subject:
- CD8-positive T-lymphocytes; adjuvants; animal models; animal ovaries; antineoplastic activity; apoptosis; epithelium; homologous recombination; immunotherapy; interferon-gamma; mice; mutation; natural killer cells; neoplasm cells; ovarian neoplasms; patients; ribose; tumor necrosis factor-alpha; tumor suppressor proteins
- Abstract:
- ... Familial breast and ovarian cancer are often caused by inherited mutations of BRCA1. While current prognoses for such patients are rather poor, inhibition of poly-ADP ribose polymerase 1 (PARP1) induces synthetic lethality in cells that are defective in homologous recombination. BMN 673 is a potent PARP1 inhibitor that is being clinically evaluated for treatment of BRCA-mutant cancers. Using the B ...
- DOI:
- 10.1016/j.bbrc.2015.05.083
- https://doi.org/10.1016/j.bbrc.2015.05.083
- Author:
- Yanyan Jia; Huirong Shi; Yuan Cao; Wenlong Feng; Meijuan Li; Xueru Li
- Source:
- Life sciences 2019 v.233 pp. 116715
- ISSN:
- 0024-3205
- Subject:
- animal ovaries; antineoplastic activity; carcinogenesis; cell growth; gene overexpression; lymph nodes; metastasis; neoplasm cells; ovarian neoplasms; patients; phosphorylation; prognosis; therapeutics; tissues; transcriptional activation
- Abstract:
- ... PDZ and LIM domain protein 4 (PDLIM4) is frequently repressed in cancer tissues. However, the expression and role of PDLIM4 in ovarian cancer has not been addressed.In this study, we examined the expression and prognostic significance of PDLIM4 in ovarian cancer. The function of PDLIM4 in ovarian cancer cell growth, invasion, and tumorigenesis was further explored.PDLIM4 is downregulated in ovaria ...
- DOI:
- 10.1016/j.lfs.2019.116715
- https://doi.org/10.1016/j.lfs.2019.116715
- Author:
- Quan V. Vuong; Sathira Hirun; Tiffany L.K. Chuen; Chloe D. Goldsmith; Benjamin Munro; Michael C. Bowyer; Anita C. Chalmers; Jennette A. Sakoff; Phoebe A. Phillips; Christopher J. Scarlett
- Source:
- Industrial crops and products 2015 v.64 pp. 167-174
- ISSN:
- 0926-6690
- Subject:
- Eucalyptus robusta; alpha-tocopherol; animal ovaries; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; brain; coasts; colon; drug therapy; essential oils; health promotion; leaf extracts; leaves; pancreatic neoplasms; phenolic compounds; spray drying; toxicity; trees; Australia
- Abstract:
- ... Eucalyptus robusta (Sm.) (ER) is a widely distributed tree native to the east coast of Australia, which has also been established in numerous other countries. ER leaves contain high levels of essential oils and are rich in total phenolic compounds (TPC), which have been linked with health benefits; however, there is limited information on the bioactivity of ER leaf extracts. This study aimed to op ...
- DOI:
- 10.1016/j.indcrop.2014.10.061
- https://doi.org/10.1016/j.indcrop.2014.10.061
- Author:
- Zuqin Xue; Miaoxin Lin; Jianhui Zhu; Junfeng Zhang; Yizhi Li; Zijian Guo
- Source:
- Chemical communications 2010 v.46 no.8 pp. 1212-1214
- ISSN:
- 1364-548X
- Subject:
- animal ovaries; antineoplastic activity; apoptosis; aqueous solutions; cell lines; chemical communication; chemical reactions; cisplatin; crystal structure; cytotoxicity; humans; moieties; osteosarcoma; ovarian neoplasms; phosphonates; platinum; solubility
- Abstract:
- ... Platinum(ii) complexes bearing geminal bisphosphonate moieties have excellent solubility in both organic and aqueous solutions and show considerable cytotoxicity against human osteosarcoma (MG-63) and ovarian cancer (COC1) cell lines with different apoptotic pathways from that of cisplatin. ...
- DOI:
- 10.1039/b922222g
- https://doi.org/10.1039/b922222g
- Author:
- Umasankar De; Ji Yeon Son; Yukyoung Jeon; Song-Yi Ha; Yu Jin Park; Sungpil Yoon; Ki-Tae Ha; Wahn Soo Choi; Byung Mu Lee; In Su Kim; Jong Hwan Kwak; Hyung Sik Kim
- Source:
- Food and chemical toxicology 2019 v.123 pp. 492-500
- ISSN:
- 0278-6915
- Subject:
- Nepenthes alata; adverse effects; animal models; animal ovaries; antineoplastic activity; apoptosis; breast neoplasms; cell cycle checkpoints; cyclins; cysteine; cytochrome c; cytotoxicity; epithelium; humans; mice; neoplasm cells; ovarian neoplasms; plumbagin; reactive oxygen species; therapeutics
- Abstract:
- ... Plumbagin (5-hydroxy-2-methyl-1,4-naphthaquinone) has displayed antitumor activity in vitro and in animal models; however, the underlying molecular mechanisms have not been fully explored. The aim of this study was to investigate the anticancer effects of plumbagin isolated from Nepenthes alata against MCF-7 breast cancer cells. We examined the cytotoxicity, cell cycle regulation, apoptotic cell d ...
- DOI:
- 10.1016/j.fct.2018.11.040
- https://doi.org/10.1016/j.fct.2018.11.040
- Author:
- Qiheng Gou; Lei Liu; Chunting Wang; Qinjie Wu; Lu Sun; Xi Yang; Yuxin Xie; Ping Li; Changyang Gong
- Source:
- Colloids and Surfaces B: Biointerfaces 2015 v.126 pp. 26-34
- ISSN:
- 0927-7765
- Subject:
- adenocarcinoma; animal ovaries; antineoplastic activity; apoptosis; biodegradability; cell cycle; cell viability; colloids; curcumin; cytotoxicity; encapsulation; inhibitory concentration 50; micelles; multiple drug resistance; ovarian neoplasms; solubility; therapeutics
- Abstract:
- ... The increasing emergence of multidrug-resistant (MDR) cells presents a challenge to effective cancer therapy. Curcumin (CUR) has multifunctional anticancer properties, but its clinical use has been limited by poor solubility. We developed biodegradable polymeric micelles entrapping CUR in order to improve its antitumor activity and to explore whether it could treat MDR cells. This delivery system ...
- DOI:
- 10.1016/j.colsurfb.2014.12.012
- https://doi.org/10.1016/j.colsurfb.2014.12.012
- Author:
- Ludmila Yarmolinsky; Gabit Bari; Rachel Hamias; Hani Maor; Arie Budovsky; Marina Wolfson; Vadim Fraifeld; Michael Danilenko; Shimon Ben-Shabat
- Source:
- Israel journal of plant sciences 2015 v.62 no.4 pp. 229-233
- ISSN:
- 2223-8980
- Subject:
- Varthemia; animal ovaries; antineoplastic activity; chemotypes; cytotoxicity; flavonoids; humans; lung neoplasms; melanoma; myeloid leukemia; neoplasm cells; viability; Israel
- Abstract:
- ... The present study was aimed at investigating the anti-cancer properties of the unique chemotype of Varthemia iphionoides (V. iphionoides) growing in the Judaea region (Israel). Specifically, we determined the effects of the crude ethanolic extract of V. iphionoides on the growth and viability of human cancer cell lines (SKOV3 ovarian carcinoma cells, BG melanoma cells, A549 lung cancer cells, and ...
- DOI:
- 10.1080/07929978.2015.1027122
- https://doi.org/10.1080/07929978.2015.1027122
- Author:
- Yuhong Liu; Yuguo Liu; Haiqiang Jiang; Lingchuan Xu; Yanna Cheng; Peng George Wang; Fengshan Wang
- Source:
- Carbohydrate polymers 2014 v.106 pp. 42-48
- ISSN:
- 0144-8617
- Subject:
- Danio rerio; Phellinus; animal ovaries; antineoplastic activity; beta-glucans; cytotoxicity; hepatoma; human umbilical vein endothelial cells; humans; immunohistochemistry; mice; neoplasm cells; ovarian neoplasms; vascular endothelial growth factors
- Abstract:
- ... Two sulfated derivatives (PRP-S1 and PRP-S2) of a β-glucan from Phellinus ribis with different degrees of substitution were obtained by chlorosulfonic acid method. The derivatives could block formation of new vessels in zebrafish and inhibit the proliferation of human umbilical vein endothelial cells (HUVECs). The two sulfated derivatives had remarkably high antitumor activities in vivo (in BALB/c ...
- DOI:
- 10.1016/j.carbpol.2014.01.088
- https://doi.org/10.1016/j.carbpol.2014.01.088
- Author:
- Jingna Wu; Xiaoting Chen; Kun Qiao; Yongchang Su; Zhiyu Liu
- Source:
- Food science and human wellness 2021 v.10 no.1 pp. 63-71
- ISSN:
- 2213-4530
- Subject:
- Bangia; acid hydrolysis; animal ovaries; anion exchange; antineoplastic activity; arabinose; galactose; gas chromatography-mass spectrometry; gel chromatography; glucose; mannose; methylation; molecular weight; neoplasm cells; nuclear magnetic resonance spectroscopy; ovarian neoplasms; polysaccharides; rhamnose; water solubility
- Abstract:
- ... A water-soluble polysaccharide, designated BFP-3, was isolated from Bangia fuscopurpurea by hot water extraction, anion-exchange, and size-exclusion chromatography and tested to determine its antitumor activity. The structural characteristics of BFP-3 were investigated by chemical and spectroscopic methods, including partial acid hydrolysis, methylation analysis, one- and two-dimensional nuclear m ...
- DOI:
- 10.1016/j.fshw.2020.05.003
- https://doi.org/10.1016/j.fshw.2020.05.003
- Author:
- Jeon Mijin; Mishra Neeraj Kumar; De Umasankar; Sharma Satyasheel; Oh Yongguk; Choi Miji; Jo Hyeim; Sachan Richa; Kim Hyung Sik; Kim In Su
- Source:
- Journal of organic chemistry 2016 v.81 no.20 pp. 9878-9885
- ISSN:
- 1520-6904
- Subject:
- adenocarcinoma; animal ovaries; antineoplastic activity; carbon-hydrogen bond activation; cytotoxicity; doxorubicin; endometrium; humans; neoplasm cells; organic chemistry; ovarian neoplasms; rhodium; synthesis
- Abstract:
- ... The rhodium(III)-catalyzed direct C–H functionalization of various indolines with 1,4,2-dioxazol-5-ones as new amidating agents is described. This transformation provides efficient preparation of C7-amidated indolines known to display potent anticancer activity. The synthetic compounds were evaluated for in vitro anticancer activity against human prostate adenocarcinoma cells (LNCaP), human endome ...
- DOI:
- 10.1021/acs.joc.6b02020
- https://doi.org/10.1021/acs.joc.6b02020
- Author:
- Jae Ryul Bae; Wook Ha Park; Dong Hoon Suh; Jae Hong No; Yong Beom Kim; Kidong Kim
- Source:
- BMC complementary medicine and therapies 2020 v.20 no.1 pp. 94
- ISSN:
- 2662-7671
- Subject:
- Euodia; adverse effects; animal ovaries; antineoplastic activity; antineoplastic agents; apoptosis; cancer therapy; cell viability; drug resistance; drug therapy; fluorescent antibody technique; fractionation; human cell lines; immunoblotting; limonin; neoplasm cells; ovarian neoplasms; patients; signal transduction; staining
- Abstract:
- ... BACKGROUND: Ovarian cancer therapy generally involves systemic chemotherapy with anticancer drugs; however, chemotherapy with a platinum-based drug has often been shown to cause adverse reactions and drug resistance in ovarian cancer patients. Evodia rutaecarpa (ER) reportedly shows anticancer activity against various types of cancer cells. However, the effects of ER have not yet been fully uncove ...
- DOI:
- 10.1186/s12906-020-02890-y
- PubMed:
- 32197606
- PubMed Central:
- PMC7085187
- https://doi.org/10.1186/s12906-020-02890-y
- Author:
- Pasko Pawel; Bukowska-Strakova Karolina; Gdula-Argasinska Joanna; Tyszka-Czochara Malgorzata
- Source:
- Journal of medicinal food 2013 v.16 no.8 pp. 749-759
- ISSN:
- 1557-7600
- Subject:
- Brassica napus; Chinese hamsters; animal ovaries; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; bioassays; cell membranes; cytotoxicity; flavonoids; functional foods; hepatoma; human cell lines; humans; in vitro studies; luminescence; methanol; neoplasm cells; nutrient content; polyphenols; roots; seeds; vegetables; Europe; North America
- Abstract:
- ... Although rutabaga (Brassica napus L. var. napobrassica) is a popular crop, especially in North Europe and North America, its sprouts are a new kind of vegetable. Rutabaga roots, and particularly sprouts, have not been investigated so far for antioxidant and anticancer effect on human tumor cells (Hep G2). Therefore, in vitro tests were conducted to find out whether rutabaga seeds, roots, and sprou ...
- DOI:
- 10.1089/jmf.2012.0250
- https://doi.org/10.1089/jmf.2012.0250
- Author:
- Yuanda Du; Renqing Wang; Jinhong Feng; Haijie Zhang; Jian Liu
- Source:
- Biology and environment 2014 v.114 no.2 pp. 79-87
- ISSN:
- 0791-7945
- Subject:
- Potamogeton crispus; alcohols; animal ovaries; antineoplastic activity; apoptosis; biomass; breast neoplasms; constructed wetlands; cytotoxicity; death; engineering; ethyl acetate; humans; interphase; macrophytes; necrosis; neoplasm cells; ovarian neoplasms; petroleum; pollutants; risk; screening; secondary metabolites; vegetative growth; wetland plants
- Abstract:
- ... Potamogeton crispus L. is a cosmopolitan aquatic macrophyte that has been deployed in constructed wetland as engineering species for ecological and purification functions. However, the extraordinary rapid vegetative growth of P. crispus requires that the species be harvested at the appropriate time to ensure the effectiveness of pollutant removal and minimise the risk of secondary po ...
- DOI:
- 10.3318/BIOE.2014.19
- https://doi.org/10.3318/BIOE.2014.19
- Author:
- Kyungjae Andrew Yoon; Kyungmun Kim; A-Young Kim; Young Han Park; Woo Young Bang; Changmu Kim; Joo-Hong Yeo; Young Ho Koh; Si Hyeock Lee
- Source:
- Journal of Asia-Pacific entomology 2016 v.19 no.3 pp. 821-828
- ISSN:
- 1226-8615
- Subject:
- Candida albicans; Vespa; animal ovaries; antineoplastic activity; chemotaxis; circular dichroism spectroscopy; complementary DNA; drug carriers; drugs; hemolysis; ovarian neoplasms; peptides; venoms
- Abstract:
- ... We identified vespid chemotactic peptide (VCP) and vespakinin (Vespk) from the lesser paper wasp, Parapolybia varia. The cDNA, genomic DNA, and mature peptide sequences of P. varia VCP (PvVCP) and Vespk (PvVespk) were determined. To investigate the pharmacological and toxicological properties of PvVCP and PvVespk, their hemolytic, anti-microbial, anti-fungal, and anti-tumor activities were evaluat ...
- DOI:
- 10.1016/j.aspen.2016.07.015
- https://doi.org/10.1016/j.aspen.2016.07.015