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- Author:
- Jingna Wu; Xiaoting Chen; Kun Qiao; Yongchang Su; Zhiyu Liu
- Source:
- Food science and human wellness 2021 v.10 no.1 pp. 63-71
- ISSN:
- 2213-4530
- Subject:
- Bangia; acid hydrolysis; animal ovaries; anion exchange; antineoplastic activity; arabinose; galactose; gas chromatography-mass spectrometry; gel chromatography; glucose; mannose; methylation; molecular weight; neoplasm cells; nuclear magnetic resonance spectroscopy; ovarian neoplasms; polysaccharides; rhamnose; water solubility
- Abstract:
- ... A water-soluble polysaccharide, designated BFP-3, was isolated from Bangia fuscopurpurea by hot water extraction, anion-exchange, and size-exclusion chromatography and tested to determine its antitumor activity. The structural characteristics of BFP-3 were investigated by chemical and spectroscopic methods, including partial acid hydrolysis, methylation analysis, one- and two-dimensional nuclear m ...
- DOI:
- 10.1016/j.fshw.2020.05.003
- https://doi.org/10.1016/j.fshw.2020.05.003
- Author:
- Nana Bie; Lirong Han; Meng Meng; Yuanyuan Zhang; Mingzhu Guo; Chunling Wang
- Source:
- Journal of functional foods 2020 v.65 pp. 103739
- ISSN:
- 1756-4646
- Subject:
- T-lymphocytes; animal models; animal ovaries; antineoplastic activity; apoptosis; caspase-3; cell proliferation; cytochrome c; eicosapentaenoic acid; human diseases; immunomodulators; macrophages; mitogen-activated protein kinase; natural killer cells; neoplasm cells; ovarian neoplasms; phagocytosis; phosphatidylinositol 3-kinase; phosphorylation; rats; spleen; splenocytes; thymus gland; transcription factor NF-kappa B
- Abstract:
- ... Eicosapentaenoic acid (EPA) has been known to induce human ovarian cancer cells apoptosis in vitro. However, the anti-tumor mechanisms of EPA in vivo have been rarely reported. In this study, the effect of EPA on the ovarian cancer rat model and its related mechanism were investigated. The results showed after EPA treatment, the index of spleens and thymus was significantly increased, and the prol ...
- DOI:
- 10.1016/j.jff.2019.103739
- https://doi.org/10.1016/j.jff.2019.103739
- Author:
- Min Ju Kim; So Jin Lee; Ju Hee Ryu; Sun Hwa Kim; Ick Chan Kwon; Thomas M. Roberts
- Source:
- Journal of controlled release 2020 v.318 pp. 98-108
- ISSN:
- 0168-3659
- Subject:
- allografting; animal ovaries; antineoplastic activity; apoptosis; carcinogenesis; cell proliferation; chitosan; drug development; drug resistance; enzyme inhibition; gene silencing; models; mutation; ovarian neoplasms; phosphatidylinositol 3-kinase; polymerization; signal transduction; small interfering RNA
- Abstract:
- ... The phosphoinositide 3-kinase (PI3K) and RAS signaling pathways are frequently co-activated and altered during oncogenesis. Owing to their regulatory cross-talk, the early attempts of targeting only one pathway have mostly ended up promoting the development of drug resistance. Here, we propose using small interfering RNA (siRNA) therapeutics to directly target the undruggable KRAS (siKRAS) in comb ...
- DOI:
- 10.1016/j.jconrel.2019.12.019
- PubMed:
- 31838203
- PubMed Central:
- PMC7056267
- https://doi.org/10.1016/j.jconrel.2019.12.019
- Author:
- Eunbi Jo; Hyun-Jin Jang; Kyeong Eun Yang; Min Su Jang; Yang Hoon Huh; Hwa-Seung Yoo; Jun Soo Park; Ik-Soon Jang; Soo Jung Park
- Source:
- BMC complementary medicine and therapies 2020 v.20 no.1 pp. 1
- ISSN:
- 2662-7671
- Subject:
- B-cell lymphoma; Cordyceps militaris; animal ovaries; antineoplastic activity; apoptosis; caspases; cell proliferation; cell viability; cytosol; dose response; immunoblotting; immunocytochemistry; interleukin-1beta; mechanism of action; microarray technology; neoplasm cells; ovarian neoplasms; phosphorylation; transcription factor NF-kappa B; transmission electron microscopy; tumor necrosis factor receptors; tumor necrosis factor-alpha
- Abstract:
- ... BACKGROUND: Cordyceps militaris (L.) Fr. (C. militaris) exhibits pharmacological activities, including antitumor properties, through the regulation of the nuclear factor kappa B (NF-κB) signaling. Tumor Necrosis Factor (TNF) and TNF-α modulates cell survival and apoptosis through NF- κB signaling. However, the mechanism underlying its mode of action on the NF-κB pathway is unclear. METHODS: Here, ...
- DOI:
- 10.1186/s12906-019-2780-5
- PubMed:
- 32020859
- PubMed Central:
- PMC7076896
- https://doi.org/10.1186/s12906-019-2780-5
- Author:
- Jingjing Li; Fan Tang; Renkai Li; Zhejie Chen; Simon Ming-Yuen Lee; Chaomei Fu; Jinming Zhang; George Pak-Heng Leung
- Source:
- Journal of nutritional biochemistry 2020 v.77 pp. 108268
- ISSN:
- 0955-2863
- Subject:
- Danio rerio; angiogenesis; animal ovaries; antineoplastic activity; apoptosis; bioactive compounds; blood vessels; caspase-3; caspase-9; cell cycle checkpoints; cyclins; ex vivo studies; glycyrrhetinic acid; human umbilical vein endothelial cells; in vitro studies; in vivo studies; interphase; licorice; mechanism of action; membrane potential; mice; mitochondrial membrane; mitogen-activated protein kinase; models; neoplasm cells; ovarian neoplasms; phosphorylation; pro-apoptotic proteins; rats; receptors; signal transduction; vascular endothelial growth factor receptor-2
- Abstract:
- ... Glycyrrhetinic acid (GA) is a major bioactive compound of licorice. The objective of this study was to investigate the effects of GA on ovarian cancer, particularly those related to angiogenesis and apoptosis, and to elucidate the underlying mechanisms of action. In vitro studies showed that GA significantly inhibited proliferation, migration, invasion and tube formation in human umbilical vein en ...
- DOI:
- 10.1016/j.jnutbio.2019.108268
- https://doi.org/10.1016/j.jnutbio.2019.108268
- Author:
- Luis Varela-Rodríguez; Blanca Sánchez-Ramírez; Verónica Ivonne Hernández-Ramírez; Hugo Varela-Rodríguez; Rodrigo Daniel Castellanos-Mijangos; Carmen González-Horta; Bibiana Chávez-Munguía; Patricia Talamás-Rohana
- Source:
- BMC complementary medicine and therapies 2020 v.20 no.1 pp. 110
- ISSN:
- 2662-7671
- Subject:
- adenocarcinoma; alanine transaminase; analysis of variance; animal ovaries; antineoplastic activity; antineoplastic agents; apoptosis; carbonate dehydratase; cell cycle checkpoints; cell viability; chronic hepatitis; computer simulation; dimethyl sulfoxide; females; gallic acid; histopathology; in vitro studies; in vivo studies; intravenous injection; leukocytes; liver; mice; models; mortality; myricetin; nuclear magnetic resonance spectroscopy; ovarian neoplasms; paclitaxel; parenchyma (animal tissue); phosphatidylinositol 3-kinase; platinum; resection; taxanes; toxicology; transmission electron microscopy; urea
- Abstract:
- ... BACKGROUND: Ovarian cancer is the leading cause of mortality among malignant gynecological tumors. Surgical resection and chemotherapy with intravenous platinum/taxanes drugs are the treatments of choice, with little effectiveness in later stages and severe toxicological effects. Therefore, this study aimed to evaluate the antineoplastic activity of gallic acid (GA) and myricetin (Myr) administrat ...
- DOI:
- 10.1186/s12906-020-02900-z
- PubMed:
- 32276584
- PubMed Central:
- PMC7149887
- https://doi.org/10.1186/s12906-020-02900-z
- Author:
- Jinju Lee; Young Jae Cho; Jeong-Won Lee; Hyung Jun Ahn
- Source:
- Journal of controlled release 2020 v.321 pp. 184-197
- ISSN:
- 0168-3659
- Subject:
- animal ovaries; antineoplastic activity; antineoplastic agents; drug resistance; drug synergism; induced resistance; kinesin; microtubules; models; neoplasm cells; ovarian neoplasms; paclitaxel; small interfering RNA; therapeutics
- Abstract:
- ... Despite the promising anticancer effects of kinesin spindle protein (KSP) inhibition, functional plasticity of kinesins induced resistance against KSP inhibitors in a variety of cancers, leading to clinical failure. Additionally, paclitaxel is a widely used anticancer agent, but drug resistance has limited its use in the recurrent cancers. To overcome resistance against KSP inhibitors, we paired K ...
- DOI:
- 10.1016/j.jconrel.2020.02.013
- https://doi.org/10.1016/j.jconrel.2020.02.013
- Author:
- Jae Ryul Bae; Wook Ha Park; Dong Hoon Suh; Jae Hong No; Yong Beom Kim; Kidong Kim
- Source:
- BMC complementary medicine and therapies 2020 v.20 no.1 pp. 94
- ISSN:
- 2662-7671
- Subject:
- Euodia; adverse effects; animal ovaries; antineoplastic activity; antineoplastic agents; apoptosis; cancer therapy; cell viability; drug resistance; drug therapy; fluorescent antibody technique; fractionation; human cell lines; immunoblotting; limonin; neoplasm cells; ovarian neoplasms; patients; signal transduction; staining
- Abstract:
- ... BACKGROUND: Ovarian cancer therapy generally involves systemic chemotherapy with anticancer drugs; however, chemotherapy with a platinum-based drug has often been shown to cause adverse reactions and drug resistance in ovarian cancer patients. Evodia rutaecarpa (ER) reportedly shows anticancer activity against various types of cancer cells. However, the effects of ER have not yet been fully uncove ...
- DOI:
- 10.1186/s12906-020-02890-y
- PubMed:
- 32197606
- PubMed Central:
- PMC7085187
- https://doi.org/10.1186/s12906-020-02890-y
- Author:
- Molood Shariati; Giovanna Lollo; Kevin Matha; Benedicte Descamps; Christian Vanhove; Leen Van de Sande; Wouter Willaert; Lieve Balcaen; Frank Vanhaecke; Jean-Pierre Benoit; Wim Ceelen; Stefaan C. De Smedt; Katrien Remaut
- Source:
- ACS applied materials & interfaces 2020 v.12 no.26 pp. 29024-29036
- ISSN:
- 1944-8252
- Subject:
- abdominal cavity; aerosols; animal models; animal ovaries; antineoplastic activity; cisplatin; drug therapy; fluorescence; human diseases; metastasis; nanocarriers; nanomedicine; nanoparticles; ovarian neoplasms; patients; surgery; synergism
- Abstract:
- ... Intra-abdominal dissemination of peritoneal nodules, a condition known as peritoneal carcinomatosis (PC), is typically diagnosed in ovarian cancer patients at the advanced stages. The current treatment of PC consists of perioperative systemic chemotherapy and cytoreductive surgery, followed by intra-abdominal flushing with solutions of chemotherapeutics such as cisplatin and oxaliplatin. In this s ...
- DOI:
- 10.1021/acsami.0c05554
- https://doi.org/10.1021/acsami.0c05554
- Author:
- Xiang-Qi Zhang; Ya-Wei Ding; Jun-Jun Chen; Xiao Xiao; Wei Zhang; Li Zhou; Qian-Wen Kong; Mei-Zhi Shi; Jiao Yang; Bo Jiang; Cheng Guo; Yong-Long Han
- Source:
- Journal of ethnopharmacology 2020 v.261 pp. 113067
- ISSN:
- 0378-8741
- Subject:
- Marsdenia tenacissima; P-glycoproteins; Western blotting; adjuvants; animal models; animal ovaries; antineoplastic activity; apoptosis; cell cycle; cell proliferation; drug therapy; dyeing; enzymes; flow cytometry; messenger RNA; mice; ovarian neoplasms; paclitaxel; plasmids; pregnanes; pro-apoptotic proteins; protein synthesis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; rhodamines; small interfering RNA; synergism; tissues; toxicity testing; traditional medicine; China
- Abstract:
- ... Xiaoaiping injection, a traditional Chinese medical injection extracted from root of Marsdenia tenacissima (Roxb.) Moon, has been exclusively used on curing malignant tumor in China and as adjuvant therapeutic agent for chemotherapeutics, including paclitaxel.The goal of this study was to investigate the synergistic inhibitory efficacy of Xiaoaiping injection and paclitaxel on ovarian cancer. The ...
- DOI:
- 10.1016/j.jep.2020.113067
- https://doi.org/10.1016/j.jep.2020.113067
- Author:
- Haiqin SongThe two authors contributed equally to this work.; Feifei Quan; Zhiqiang Yu; Minhua Zheng; Yan Ma; Haihua Xiao; Fang Ding
- Source:
- Journal of materials chemistry B 2019 v.7 no.3 pp. 433-442
- ISSN:
- 2050-7518
- Subject:
- adverse effects; animal ovaries; antineoplastic activity; cell lines; chemistry; cisplatin; cytotoxicity; drug resistance; endocytosis; in vivo studies; iron oxides; magnetic fields; nanocarriers; nanoparticles; neoplasm cells; ovarian neoplasms; platinum; toxicity testing; zeta potential
- Abstract:
- ... Platinum (Pt)-based drugs including cisplatin, carboplatin and oxaliplatin have been widely used as first-line anticancer regimens due to their excellent anticancer efficacy. However, the clinical application of these drugs is greatly limited due to their side effects and drug resistance. In this study, an antitumor drug delivery system based on carboplatin prodrug loading Fe₃O₄ nanoparticles (NPs ...
- DOI:
- 10.1039/c8tb02574f
- https://doi.org/10.1039/c8tb02574f
- Author:
- Justyna Mikuła-Pietrasik; Anna Witucka; Martyna Pakuła; Paweł Uruski; Beata Begier-Krasińska; Arkadiusz Niklas; Andrzej Tykarski; Krzysztof Książek
- Source:
- Cellular and molecular life sciences 2019 v.76 no.4 pp. 681-697
- ISSN:
- 1420-682X
- Subject:
- DNA damage; angiogenesis; animal ovaries; antineoplastic activity; apoptosis; cell senescence; drug therapy; drugs; endothelial cells; epithelial cells; fibroblasts; metabolism; mitophagy; neurons; ovarian neoplasms; oxidative stress; somatic cells
- Abstract:
- ... One of the most neglected aspects of chemotherapy are changes, and possible consequences of these changes, that occur in normal somatic cells. In this review, we summarize effects of selected drugs used to treat ovarian cancer (platin derivatives—cisplatin and carboplatin; and taxanes—paclitaxel and docetaxel) on cellular metabolism, acquisition of reactive stroma features, cellular senescence, in ...
- DOI:
- 10.1007/s00018-018-2954-1
- PubMed:
- 30382284
- PubMed Central:
- PMC6514066
- https://doi.org/10.1007/s00018-018-2954-1
- Author:
- Jinsha Koroth; Snehal Nirgude; Shweta Tiwari; Vidya Gopalakrishnan; Raghunandan Mahadeva; Sujeet Kumar; Subhas S. Karki; Bibha Choudhary
- Source:
- BMC complementary and alternative medicine 2019 v.19 no.1 pp. 273
- ISSN:
- 1472-6882
- Subject:
- Western blotting; adverse effects; alternative medicine; animal ovaries; antineoplastic activity; apoptosis; bioavailability; breast neoplasms; cell lines; cell movement; curcumin; cytotoxicity; flow cytometry; interstitial collagenase; liquids; metastasis; neoplasm cells; ovarian neoplasms; stem cells; toxicity testing
- Abstract:
- ... BACKGROUND: Curcumin is known for its multitude of medicinal properties, including anti-cancer and migrastatic activity. Efforts to overcome poor bioavailability, stability, and side effects associated with the higher dose of curcumin has led to the development of newer derivatives of curcumin. Thus, the focus of this study is to screen novel curcumin derivatives, namely ST03 and ST08, which have ...
- DOI:
- 10.1186/s12906-019-2685-3
- PubMed:
- 31638975
- PubMed Central:
- PMC6802352
- https://doi.org/10.1186/s12906-019-2685-3
- Author:
- Yanyan Jia; Huirong Shi; Yuan Cao; Wenlong Feng; Meijuan Li; Xueru Li
- Source:
- Life sciences 2019 v.233 pp. 116715
- ISSN:
- 0024-3205
- Subject:
- animal ovaries; antineoplastic activity; carcinogenesis; cell growth; gene overexpression; lymph nodes; metastasis; neoplasm cells; ovarian neoplasms; patients; phosphorylation; prognosis; therapeutics; tissues; transcriptional activation
- Abstract:
- ... PDZ and LIM domain protein 4 (PDLIM4) is frequently repressed in cancer tissues. However, the expression and role of PDLIM4 in ovarian cancer has not been addressed.In this study, we examined the expression and prognostic significance of PDLIM4 in ovarian cancer. The function of PDLIM4 in ovarian cancer cell growth, invasion, and tumorigenesis was further explored.PDLIM4 is downregulated in ovaria ...
- DOI:
- 10.1016/j.lfs.2019.116715
- https://doi.org/10.1016/j.lfs.2019.116715
- Author:
- Umasankar De; Ji Yeon Son; Yukyoung Jeon; Song-Yi Ha; Yu Jin Park; Sungpil Yoon; Ki-Tae Ha; Wahn Soo Choi; Byung Mu Lee; In Su Kim; Jong Hwan Kwak; Hyung Sik Kim
- Source:
- Food and chemical toxicology 2019 v.123 pp. 492-500
- ISSN:
- 0278-6915
- Subject:
- Nepenthes alata; adverse effects; animal models; animal ovaries; antineoplastic activity; apoptosis; breast neoplasms; cell cycle checkpoints; cyclins; cysteine; cytochrome c; cytotoxicity; epithelium; humans; mice; neoplasm cells; ovarian neoplasms; plumbagin; reactive oxygen species; therapeutics
- Abstract:
- ... Plumbagin (5-hydroxy-2-methyl-1,4-naphthaquinone) has displayed antitumor activity in vitro and in animal models; however, the underlying molecular mechanisms have not been fully explored. The aim of this study was to investigate the anticancer effects of plumbagin isolated from Nepenthes alata against MCF-7 breast cancer cells. We examined the cytotoxicity, cell cycle regulation, apoptotic cell d ...
- DOI:
- 10.1016/j.fct.2018.11.040
- https://doi.org/10.1016/j.fct.2018.11.040
- Author:
- Peng-Cheng LIN; Lin-Lin JI; Xiang-Jian ZHONG; Jin-Jie LI; Xin WANG; Xiao-Ya SHANG; Sheng LIN
- Source:
- Chinese journal of natural medicines 2019 v.17 no.1 pp. 22-26
- ISSN:
- 1875-5364
- Subject:
- Cirsium arvense; Oriental traditional medicine; animal ovaries; antineoplastic activity; cell lines; chemical structure; colorectal neoplasms; cytotoxicity; food plants; humans; inhibitory concentration 50; ovarian neoplasms; secretion; spectral analysis; triterpenoids; tumor necrosis factor-alpha
- Abstract:
- ... Guided by TNF-α secretion inhibitory activity assay, four taraxastane-type triterpenoids, including two new ones, 22-oxo-20-taraxasten-3β, 30-diol (1) and 22α-hydroxy-20-taraxasten-30β, 30-triol (2), have been obtained from an active fraction of the petroleum ether-soluble extract of the the medicinal and edible plant Cirsium setosum. Their structures were elucidated by spectroscopic data and CD d ...
- DOI:
- 10.1016/S1875-5364(19)30005-6
- https://doi.org/10.1016/S1875-5364(19)30005-6
- Author:
- Qi Li; Xinglan An; Xiaxia Man; Meiran Chu; Tianchuang Zhao; Hao Yu; Ziyi Li
- Source:
- Life sciences 2019 v.239 pp. 116999
- ISSN:
- 0024-3205
- Subject:
- adverse effects; animal ovaries; antineoplastic activity; biosynthesis; blood serum; cholesterol; cyclophosphamide; enzyme-linked immunosorbent assay; eosin; estradiol; follicle-stimulating hormone; gene expression regulation; genes; intraperitoneal injection; mice; peroxisome proliferator-activated receptors; protein-protein interactions; quantitative polymerase chain reaction; sequence analysis; signal transduction; staining; toxicity; transcriptome; transcriptomics
- Abstract:
- ... The present study aimed to investigate the effects of cyclophosphamide (Cytoxan, CTX) on premature ovarian failure (POF) in mice and its regulatory mechanisms by transcriptome analysis.Female C57BL/6 mice were treated with a single intraperitoneal injection of 70 mg/kg CTX. Serum levels of estradiol (E₂) and follicle stimulating hormone (FSH) were measured by enzyme-linked immunosorbent assay (ELI ...
- DOI:
- 10.1016/j.lfs.2019.116999
- https://doi.org/10.1016/j.lfs.2019.116999
- Author:
- Pengyan Jiao; Jian Zhang; Yuguo Dong; Dongzhi Wei; Yuhong Ren
- Source:
- Applied microbiology and biotechnology 2018 v.102 no.22 pp. 9585-9594
- ISSN:
- 0175-7598
- Subject:
- adenine; animal ovaries; antineoplastic activity; catalytic activity; cell death; endoplasmic reticulum; enzymes; fluorescent antibody technique; in vitro studies; lung neoplasms; neoplasm cells; ovarian neoplasms; recombinant proteins; ribosomal RNA; ricin; therapeutics; toxicity; translation (genetics)
- Abstract:
- ... The specific targeting of immunotoxins enables their wide application in cancer therapy. The A-chain of the ricin protein (RTA) is an N-glycosidase that catalyzes the removal of adenine from the 28S rRNA, preventing protein translation and leading to cell death. Ricin is highly toxic but can only exert its toxic effects from within the cytoplasm. In this study, we linked the anti-HER2 single-chain ...
- DOI:
- 10.1007/s00253-018-9291-z
- https://doi.org/10.1007/s00253-018-9291-z
- Author:
- Guangya Xu; Bin Li; Ting Wang; Jun Wan; Yan Zhang; Jingwei Huang; Yangmei Shen
- Source:
- RSC advances 2018 v.8 no.38 pp. 21229-21242
- ISSN:
- 2046-2069
- Subject:
- animal models; animal ovaries; antineoplastic activity; apoptosis; bioavailability; cell growth; cytotoxicity; drug delivery systems; drugs; growth retardation; hydrogels; micelles; nanotechnology; ovarian neoplasms; particle size; quercetin; tissues; water solubility
- Abstract:
- ... Ovarian cancer, as one of the killers that threaten women’s health, has been studied extensively. As a natural bioflavonoid with prospective effects, quercetin is highly recognized for its anti-cancer applications. However, one of the major challenges that quercetin faces is its poor water solubility, instability in physiological media, and subsequent poor bioavailability. Thus, optimizing the ide ...
- DOI:
- 10.1039/c8ra03274b
- https://doi.org/10.1039/c8ra03274b
- Author:
- Sha Xiao; Ming Zhang; Chang Liu; Deling Wang
- Source:
- Molecular genetics and genomics 2018 v.293 no.5 pp. 1159-1167
- ISSN:
- 1617-4615
- Subject:
- adenosine triphosphate; animal ovaries; antineoplastic activity; cisplatin; data collection; drug therapy; gene expression; luciferase; neoplasm cells; ovarian neoplasms; patients; prognosis; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction
- Abstract:
- ... Cisplatin is one of the most popular chemotherapeutic drugs in treating ovarian cancer. Resistance to cisplatin is a common clinical challenge that needs to be solved to increase its anti-tumor effects. The relation of miR-514 expression with prognosis in ovarian cancer patients was analyzed based on GSE73584 datasets. The regulation of miR-514 on proliferation and cisplatin chemosensitivity of ov ...
- DOI:
- 10.1007/s00438-018-1447-0
- https://doi.org/10.1007/s00438-018-1447-0
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