Subject: antibiotics and evolution - PubAg Search Results

1. Systematics and bionomics of the apoid obligate necrophages: the Trigona hypogea group (Hymenoptera: Apidae; Meliponinae)

Author:: CAMARGO, JOÃO M.F.; ROUBIK, DAVID W.
Source:: Biological journal of the Linnean Society 1991 v.44 no.1 pp. 13-39
ISSN:: 0024-4066
Subject:: Trigona; foods; queen cells; antibiotics; evolution; necrophagy; teeth; trail pheromones; palps; beneficial microorganisms; Corbicula; pollen; dead animals; worker bees; stingless bees; foraging; honey
Abstract:: ... A systematic revision and biological account is given of the only apoid obligate necrophages, the Trigona hypogea group, along with descriptions of Trigona necrophaga sp. nov. and the male of Trigona crassipes. Trigona necrophaga is endemic to eastern Panama and possibly the Chocó; T. hypogea and T. crassipes are sympatric throughout the Amazon Basin and the Guianas. The lack of a corbicula on the ...
DOI:: 10.1111/j.1095-8312.1991.tb00604.x
: https://doi.org/10.1111/j.1095-8312.1991.tb00604.x

2. Environmentally friendly approaches to genetic engineering

Author:: Daniell, H.
Source:: In vitro cellular & developmental biology 1999 v.35 no.5 pp. 361-368
ISSN:: 1054-5476
Subject:: maternal effect; antibiotics; evolution; transgenic plants; gene flow; Bacillus thuringiensis; genes; genetic engineering; bacterial toxins; crystal proteins; environmental impact; nontarget organisms; wild relatives; pollen; inheritance (genetics); adverse effects; chloroplasts; drug resistance
DOI:: 10.1007/s11627-999-0049-2
: https://doi.org/10.1007/s11627-999-0049-2

3. The Exoskeleton of Bacterial Cells (the Sacculus): Still a Highly Attractive Target for Antibacterial Agents That Will Last For a Long Time

Author:: Arthur L. Koch
Source:: Critical reviews in microbiology 2000 v.26 no.1 pp. 1-35
ISSN:: 1549-7828
Subject:: antibiotic resistance; antibiotics; bacteria; biophysics; cell walls; chemical bonding; cytoplasm; drug therapy; evolution; exoskeleton; metabolism; mutation; osmotic pressure
Abstract:: ... Most bacteria are entirely surrounded by a strong cell wall held together by covalent bonds of strength similar to those holding the atoms in a diamond together. This exoskeleton is a coat of armor or corset and is usually called a sacculus. It protects the bacterium from the stresses resulting from the higher osmotic pressure of the cytoplasm when compared with its environment. This strategy of c ...
DOI:: 10.1080/10408410091154165
: https://doi.org/10.1080/10408410091154165

4. Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins

Author:: Weinreich, Daniel M.; Delaney, Nigel F.; DePristo, Mark A.; Hartl, Daniel L.
Source:: Science 2006 v.312 no.5770 pp. 111-114
ISSN:: 0036-8075
Subject:: alleles; antibiotics; drug resistance; evolution; missense mutation; pleiotropy; point mutation; proteins
Abstract:: ... Five point mutations in a particular {szligbeta}-lactamase allele jointly increase bacterial resistance to a clinically important antibiotic by a factor of [approximately]100,000. In principle, evolution to this high-resistance {szligbeta}-lactamase might follow any of the 120 mutational trajectories linking these alleles. However, we demonstrate that 102 trajectories are inaccessible to Darwinian ...
DOI:: 10.1126/science.1123539
: https://doi.org/10.1126/science.1123539

5. Understanding the rise of the superbug: investigation of the evolution and genomic variation of Staphylococcus aureus

Author:: Jodi A. Lindsay; Matthew T. G. Holden
Source:: Functional & integrative genomics 2006 v.6 no.3 pp. 186-201
ISSN:: 1438-793X
Subject:: Staphylococcus aureus; antibiotics; bacteria; chromosomes; evolution; genetic variation; genome; genomics; human diseases; virulence
Abstract:: ... The bacterium Staphylococcus aureus is a common cause of human infection, and it is becoming increasingly virulent and resistant to antibiotics. Our understanding of the evolution of this species has been greatly enhanced by the recent sequencing of the genomes of seven strains of S. aureus. Comparative genomic analysis allows us to identify variation in the chromosomes and understand the mechanis ...
DOI:: 10.1007/s10142-005-0019-7
: https://doi.org/10.1007/s10142-005-0019-7

6. Microbial intervention for better fish health in aquaculture: the Indian scenario

Author:: Panigrahi, A.; Azad, I. S.
Source:: Fish physiology and biochemistry 2007 v.33 no.4 pp. 429-440
ISSN:: 0920-1742
Subject:: adverse effects; antibiotics; aquaculture systems; bacteria; bioaugmentation; biological control; cell structures; cell wall components; climatic factors; drug resistance; evolution; exports; fauna; fish; fish health; fish production; food security; immunity; immunostimulants; markets; nucleic acids; pathogens; polymerase chain reaction; probiotics; vaccines; India
Abstract:: ... Aquaculture has evolved as the fastest growing food-producing sector and developed as an important component in food security. To keep a sustainable growth pattern, health management strategies must go beyond antibiotics and chemotherapeutics, which create resistant bacteria and immunosuppression in the host. Besides development of drug resistant bacteria and pathogens, the adverse effect of antib ...
DOI:: 10.1007/s10695-007-9160-7
: https://doi.org/10.1007/s10695-007-9160-7

7. Antimicrobial peptides: natural templates for synthetic membrane-active compounds

Author:: Giuliani, A.; Pirri, G.; Bozzi, A.; Di Giulio, A.; Aschi, M.; Rinaldi, A. C.
Source:: Cellular and molecular life sciences 2008 v.65 no.16 pp. 2450-2460
ISSN:: 1420-682X
Subject:: antibiotics; antimicrobial peptides; biomimetics; cell membranes; evolution; innate immunity; mechanism of action; synthetic peptides
Abstract:: ... The innate immunity of multicellular organisms relies in large part on the action of antimicrobial peptides (AMPs) to resist microbial invasion. Crafted by evolution into an extremely diversified array of sequences and folds, AMPs do share a common amphiphilic 3-D arrangement. This feature is directly linked with a common mechanism of action that predominantly (although not exclusively) develops u ...
DOI:: 10.1007/s00018-008-8188-x
PubMed:: 18661101
: https://doi.org/10.1007/s00018-008-8188-x

8. Comparative analysis of essential genes and nonessential genes in Escherichia coli K12

Author:: Gong, Xiaodong; Fan, Shaohua; Bilderbeck, Amy; Li, Mingkun; Pang, Hongxia; Tao, Shiheng
Source:: Molecular genetics and genomics 2008 v.279 no.1 pp. 87-94
ISSN:: 1617-4615
Subject:: Escherichia coli K12; amino acids; antibiotics; evolution; genes; mutagenesis; prediction; proteins
Abstract:: ... Genes can be classified as essential or nonessential based on their indispensability for a living organism. Previous researches have suggested that essential genes evolve more slowly than nonessential genes and the impact of gene dispensability on a gene's evolutionary rate is not as strong as expected. However, findings have not been consistent and evidence is controversial regarding the relation ...
DOI:: 10.1007/s00438-007-0298-x
PubMed:: 17943314
: https://doi.org/10.1007/s00438-007-0298-x

9. Evolution of pathogens in a man-made world

Author:: LEBARBENCHON, CAMILLE; BROWN, SAM P.; POULIN, ROBERT; GAUTHIER-CLERC, MICHEL; THOMAS, FRÉDÉRIC
Source:: Molecular ecology 2008 v.17 no.1 pp. 475-484
ISSN:: 0962-1083
Subject:: anthropogenic activities; antibiotics; biodiversity; climate change; ecologists; economic development; evolution; habitat fragmentation; humans; parasites; pathogens; planning; pollution; public health; researchers; vaccines; virulence; wildlife management
Abstract:: ... Human activities have resulted in substantial, large-scale environmental modifications, especially in the past century. Ecologists and evolutionary biologists are increasingly coming to realize that parasites and pathogens, like free-living organisms, evolve as the consequence of these anthropogenic changes. Although this area now commands the attention of a variety of researchers, a broad predict ...
DOI:: 10.1111/j.1365-294X.2007.03375.x
PubMed:: 18173509
: https://doi.org/10.1111/j.1365-294X.2007.03375.x

10. Pathogenomics of the staphylococci: insights into niche adaptation and the emergence of new virulent strains

Author:: Ben Zakour, Nouri L.; Guinane, Caitriona M.; Fitzgerald, J. Ross
Source:: FEMS microbiology letters 2008 v.289 no.1 pp. 1-12
ISSN:: 0378-1097
Subject:: Staphylococcus aureus; animal pathogens; antibiotics; evolution; genome; genomics; habitats; humans; nucleotide sequences; pathogenesis; sequence analysis; virulence; virulent strains
Abstract:: ... Because of its importance as a major human and animal pathogen, Staphylococcus aureus has been the focus of intensive research efforts. At the time of writing, the genomes of 14 isolates of S. aureus have been published and released into the public domain with many more genome sequencing projects underway, representing an excellent resource for studies of bacterial evolution and pathogenesis. Rece ...
DOI:: 10.1111/j.1574-6968.2008.01384.x
PubMed:: 19054087
: https://doi.org/10.1111/j.1574-6968.2008.01384.x

11. The rate of environmental change drives adaptation to an antibiotic sink

Author:: PERRON, G.G.; GONZALEZ, A.; BUCKLING, A.
Source:: Journal of evolutionary biology 2008 v.21 no.6 pp. 1724-1731
ISSN:: 1010-061X
Subject:: Pseudomonas aeruginosa; antibiotic resistance; antibiotics; bacteria; evolution; immigration; mutation
Abstract:: ... Recent accelerated trends of human-induced global changes are providing many examples of adaptation to novel environments. Although the rate of environmental change can vary dramatically, its effect on evolving populations is unknown. A crucial feature explaining the adaptation to harsh environments is the supply of beneficial mutations via immigration from a 'source' population. In this study, we ...
DOI:: 10.1111/j.1420-9101.2008.01596.x
PubMed:: 18681913
: https://doi.org/10.1111/j.1420-9101.2008.01596.x

12. Drug efflux pump deficiency and drug target resistance masking in growing bacteria

Author:: Fange, David; Nilsson, Karin; Tenson, Tanel; Ehrenberg, Måns
Source:: Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.20 pp. 8215-8220
ISSN:: 0027-8424
Subject:: antibiotics; bacteria; culture media; drugs; evolution; mutants; mutation; pathogens; transporters
Abstract:: ... Recent experiments have shown that drug efflux pump deficiency not only increases the susceptibility of pathogens to antibiotics, but also seems to "mask" the effects of mutations, that decrease the affinities of drugs to their intracellular targets, on the growth rates of drug-exposed bacteria. That is, in the presence of drugs, the growth rates of drug-exposed WT and target mutated strains are t ...
DOI:: 10.1073/pnas.0811514106
PubMed:: 19416855
PubMed Central:: PMC2688851
: https://doi.org/10.1073/pnas.0811514106

13. Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy

Author:: Lu, Timothy K.; Collins, James J.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.12 pp. 4629-4634
ISSN:: 0027-8424
Subject:: Escherichia coli; adjuvants; aminoglycosides; antibiotic resistance; antibiotics; bacteria; bacteriophages; beta-lactams; biofilm; drugs; evolution; gene targeting; genes; mice; proteins; quinolones; synthetic biology; therapeutics
Abstract:: ... Antimicrobial drug development is increasingly lagging behind the evolution of antibiotic resistance, and as a result, there is a pressing need for new antibacterial therapies that can be readily designed and implemented. In this work, we engineered bacteriophage to overexpress proteins and attack gene networks that are not directly targeted by antibiotics. We show that suppressing the SOS network ...
DOI:: 10.1073/pnas.0800442106
PubMed:: 19255432
PubMed Central:: PMC2649960
: https://doi.org/10.1073/pnas.0800442106

14. Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock

Author:: Ferwerda, Bart; Alonso, Santos; Banahan, Kathy; McCall, Matthew B.B.; Giamarellos-Bourboulis, Evangelos J.; Ramakers, Bart P.; Mouktaroudi, Maria; Fain, Pamela R.; Izagirre, Neskuts; Syafruddin, Din; Cristea, Tudor; Mockenhaupt, Frank P.; Troye-Blomberg, Marita; Kumpf, Oliver; Maiga, Boubacar; Dolo, Amagana; Doumbo, Ogobara; Sundaresan, Santhosh; Bedu-Addo, George; van Crevel, Reinout; Hamann, Lutz; Oh, Djin-Ye; Schumann, Ralf R.; Joosten, Leo A.B.; de la Rúa, Concepcion; Sauerwein, Robert; Drenth, Joost P.H.; Kullberg, Bart-Jan; van der Ven, André J.A.M.; Hill, Adrian V.; Pickkers, Peter; van der Meer, Jos W.M.; O'Neill, Luke A.J.; Netea, Mihai G.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.25 pp. 10272-10277
ISSN:: 0027-8424
Subject:: Homo sapiens; Toll-like receptor 2; Toll-like receptor 4; Toll-like receptor 9; alleles; antibiotics; cytokines; endotoxemia; evolution; homozygosity; humans; innate immunity; ligands; mutation; pathogenesis; pathogens; phenotype; septic shock; Eurasia
Abstract:: ... Adequate responses by our innate immune system toward invading pathogens were of vital importance for surviving infections, especially before the antibiotic era. Recently, a polymorphism in Mal (Ser180Leu, TIRAP rs8177374), an important adaptor protein downstream of the Toll-like receptor (TLR) 2 and 4 pathways, has been described to provide protection against a broad range of infectious pathogens ...
DOI:: 10.1073/pnas.0811273106
PubMed:: 19509334
PubMed Central:: PMC2700915
: https://doi.org/10.1073/pnas.0811273106

15. The role of antibiotics and antibiotic resistance in nature

Author:: Aminov, Rustam I.
Source:: Environmental microbiology 2009 v.11 no.12 pp. 2970-2988
ISSN:: 1462-2912
Subject:: antibiotic resistance; antibiotics; ecosystems; evolution; genes; pathogens
Abstract:: ... Investigations of antibiotic resistance from an environmental prospective shed new light on a problem that was traditionally confined to a subset of clinically relevant antibiotic-resistant bacterial pathogens. It is clear that the environmental microbiota, even in apparently antibiotic-free environments, possess an enormous number and diversity of antibiotic resistance genes, some of which are ve ...
DOI:: 10.1111/j.1462-2920.2009.01972.x
PubMed:: 19601960
: https://doi.org/10.1111/j.1462-2920.2009.01972.x

16. Adaptive landscapes and protein evolution

Author:: Carneiro, Maurício; Hartl, Daniel L.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.suppl_1 pp. 1747-1751
ISSN:: 0027-8424
Subject:: antibiotics; evolution; insecticide resistance; mutants; proteins; vaccines
Abstract:: ... The principles governing protein evolution under strong selection are important because of the recent history of evolved resistance to insecticides, antibiotics, and vaccines. One experimental approach focuses on studies of mutant proteins and all combinations of mutant sites that could possibly be intermediates in the evolutionary pathway to resistance. In organisms carrying each of the engineere ...
DOI:: 10.1073/pnas.0906192106
PubMed:: 19805125
PubMed Central:: PMC2868285
: https://doi.org/10.1073/pnas.0906192106

17. Antimicrobial natural products: an update on future antibiotic drug candidates

Author:: Muhammad Saleem; Mamona Nazir; Muhammad Shaiq Ali; Hidayat Hussain; Yong Sup Lee; Naheed Riaz; Abdul Jabbar
Source:: Natural product reports 2010 v.27 no.2 pp. 238-254
ISSN:: 1460-4752
Subject:: antibiotics; antimicrobial properties; evolution; markets; metabolites; pathogens; toxicity
Abstract:: ... Over the last decade, it has become clear that antimicrobial drugs are losing their effectiveness due to the evolution of pathogen resistance. There is therefore a continuing need to search for new antibiotics, especially as new drugs only rarely reach the market. Natural products are both fundamental sources of new chemical diversity and integral components of today's pharmaceutical compendium, a ...
DOI:: 10.1039/b916096e
: https://doi.org/10.1039/b916096e

18. Commensal bacteria play a role in mating preference of Drosophila melanogaster

Author:: Sharon, Gil; Segal, Daniel; Ringo, John M.; Hefetz, Abraham; Zilber-Rosenberg, Ilana; Rosenberg, Eugene
Source:: Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.46 pp. 20051-20056
ISSN:: 0027-8424
Subject:: Drosophila melanogaster; Lactobacillus plantarum; antibiotics; bacteria; evolution; mating behavior; microsymbionts; mixed culture; molasses; rearing; sex pheromones; starch
Abstract:: ... Development of mating preference is considered to be an early event in speciation. In this study, mating preference was achieved by dividing a population of Drosophila melanogaster and rearing one part on a molasses medium and the other on a starch medium. When the isolated populations were mixed, "molasses flies" preferred to mate with other molasses flies and "starch flies" preferred to mate wit ...
DOI:: 10.1073/pnas.1009906107
PubMed:: 21041648
PubMed Central:: PMC2993361
: https://doi.org/10.1073/pnas.1009906107

19. Disk prediffusion is a reliable method for testing colistin susceptibility in porcine E. coli strains

Author:: Boyen, F.; Vangroenweghe, F.; Butaye, P.; De Graef, E.; Castryck, F.; Heylen, P.; Vanrobaeys, M.; Haesebrouck, F.
Source:: Veterinary microbiology 2010 v.144 no.3-4 pp. 359-362
ISSN:: 0378-1135
Subject:: antibiotic resistance; antibiotics; minimum inhibitory concentration; evolution; strain differences; animal pathogenic bacteria; antimicrobial peptides; swine; pathogenicity; reliability; agar; accuracy; Escherichia coli
Abstract:: ... During the last few years, acquired resistance to colistin in Escherichia coli, but also in other bacterial species, has been reported. It has been shown that the disk diffusion test is not a reliable method for the detection of this resistance. Therefore, there is a need for a reliable and cheap test to determine colistin susceptibility of pathogenic E. coli strains. In the current research, the ...
DOI:: 10.1016/j.vetmic.2010.01.010
: https://doi.org/10.1016/j.vetmic.2010.01.010

20. Helix insertion into bilayers and the evolution of membrane proteins

Author:: Renthal, Robert
Source:: Cellular and molecular life sciences 2010 v.67 no.7 pp. 1077-1088
ISSN:: 1420-682X
Subject:: Escherichia coli; antibiotics; evolution; genome; lipid bilayers; membrane proteins; peptides
Abstract:: ... Polytopic α-helical membrane proteins cannot spontaneously insert into lipid bilayers without assistance from polytopic α-helical membrane proteins that already reside in the membrane. This raises the question of how these proteins evolved. Our current knowledge of the insertion of α-helices into natural and model membranes is reviewed with the goal of gaining insight into the evolution of membran ...
DOI:: 10.1007/s00018-009-0234-9
PubMed:: 20039094
PubMed Central:: PMC2862650
: https://doi.org/10.1007/s00018-009-0234-9

21. Origin and evolution of peptide-modifying dioxygenases and identification of the wybutosine hydroxylase/hydroperoxidase

Author:: Iyer, Lakshminarayan M.; Abhiman, Saraswathi; de Souza, Robson F.; Aravind, L.
Source:: Nucleic acids research 2010 v.38 no.16 pp. 5261-5279
ISSN:: 0305-1048
Subject:: active sites; antibiotics; bacteria; biosynthesis; catalytic activity; evolution; genomics; glycine (amino acid); hydroxylation; isomerases; nucleic acids; peroxidase; peroxidation; proteins; secondary metabolites; siderophores; sugars; tricarboxylic acid cycle
Abstract:: ... Unlike classical 2-oxoglutarate and iron-dependent dioxygenases, which include several nucleic acid modifiers, the structurally similar jumonji-related dioxygenase superfamily was only known to catalyze peptide modifications. Using comparative genomics methods, we predict that a family of jumonji-related enzymes catalyzes wybutosine hydroxylation/peroxidation at position 37 of eukaryotic tRNAPhe. ...
DOI:: 10.1093/nar/gkq265
PubMed:: 20423905
PubMed Central:: PMC2938197
: https://doi.org/10.1093/nar/gkq265

22. A public choice framework for controlling transmissible and evolving diseases

Author:: Althouse, Benjamin M.; Bergstrom, Theodore C.; Bergstrom, Carl T.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.suppl_1 pp. 1696-1701
ISSN:: 0027-8424
Subject:: antibiotic resistance; antibiotics; control methods; disease incidence; drug therapy; economic theory; evolution; influenza; mathematical models; otitis media; pandemic; tetanus; vaccination
Abstract:: ... Control measures used to limit the spread of infectious disease often generate externalities. Vaccination for transmissible diseases can reduce the incidence of disease even among the unvaccinated, whereas antimicrobial chemotherapy can lead to the evolution of antimicrobial resistance and thereby limit its own effectiveness over time. We integrate the economic theory of public choice with mathema ...
DOI:: 10.1073/pnas.0906078107
PubMed:: 20018681
PubMed Central:: PMC2868281
: https://doi.org/10.1073/pnas.0906078107

23. The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics

Author:: Auerbach, Tamar; Mermershtain, Inbal; Davidovich, Chen; Bashan, Anat; Belousoff, Matthew; Wekselman, Itai; Zimmerman, Ella; Xiong, Liqun; Klepacki, Dorota; Arakawa, Kenji; Kinashi, Haruyasu; Mankin, Alexander S.; Yonath, Ada
Source:: Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.5 pp. 1983-1988
ISSN:: 0027-8424
Subject:: Streptomyces rochei; antibiotics; binding sites; drugs; evolution; macrolides; microbial growth; protein subunits; ribosomal proteins; ribosomes
Abstract:: ... Crystallographic analysis revealed that the 17-member polyketide antibiotic lankacidin produced by Streptomyces rochei binds at the peptidyl transferase center of the eubacterial large ribosomal subunit. Biochemical and functional studies verified this finding and showed interference with peptide bond formation. Chemical probing indicated that the macrolide lankamycin, a second antibiotic produced ...
DOI:: 10.1073/pnas.0914100107
PubMed:: 20080686
PubMed Central:: PMC2804743
: https://doi.org/10.1073/pnas.0914100107

24. Characterization of L1 retrotransposition with high-throughput dual-luciferase assays

Author:: Xie, Yi; Rosser, James M.; Thompson, Tina L.; Boeke, Jef D.; An, Wenfeng
Source:: Nucleic acids research 2011 v.39 no.3 pp. e16
ISSN:: 0305-1048
Subject:: antibiotics; cultured cells; evolution; fluorescent proteins; genome; humans; luciferase; mice; plasmids; screening; transfection
Abstract:: ... Recent studies employing genome-wide approaches have provided an unprecedented view of the scope of L1 activities on structural variations in the human genome, and further reinforced the role of L1s as one of the major driving forces behind human genome evolution. The rapid identification of novel L1 elements by these high-throughput approaches demands improved L1 functional assays. However, the e ...
DOI:: 10.1093/nar/gkq1076
PubMed:: 21071410
PubMed Central:: PMC3035435
: https://doi.org/10.1093/nar/gkq1076

25. Class 1 integrons in environmental and clinical isolates of Pseudomonas aeruginosa

Author:: L. Ruiz-Martínez; L. López-Jiménez; E. Fusté; T. Vinuesa; J.P. Martínez; M. Viñas
Source:: International journal of antimicrobial agents 2011 v.38 no.5 pp. 398-402
ISSN:: 0924-8579
Subject:: Pseudomonas aeruginosa; aminoglycosides; antibiotics; chromosomes; evolution; genes; pathogens; plasmids; polymerase chain reaction
Abstract:: ... The aims of this study were to ascertain the presence and spread of class 1 integrons amongst environmental and clinical isolates of Pseudomonas aeruginosa and to characterise their variable regions. A total of 76 isolates (56 clinical and 20 environmental) were studied. The presence of plasmids was explored, and polymerase chain reaction (PCR) was used for integron detection. All amplicons were s ...
DOI:: 10.1016/j.ijantimicag.2011.06.016
: https://doi.org/10.1016/j.ijantimicag.2011.06.016

26. Competence in Streptococcus pneumoniae Is Regulated by the Rate of Ribosomal Decoding Errors

Author:: Kathleen E. Stevens; Diana Chang; Erin E. Zwack; Michael E. Sebert
Source:: mBio 2011 v.2 no.5 pp. e00071
ISSN:: 2150-7511
Subject:: Streptococcus pneumoniae; active sites; antibiotics; evolution; gene expression; genetic transformation; genome; humans; molecular chaperones; mutation; pathogens; peptides; pheromones; protein folding; protein synthesis; proteolysis; quorum sensing; respiratory system; ribosomal proteins; ribosomes; serine proteinases; signal transduction; translation (genetics)
Abstract:: ... Competence for genetic transformation in Streptococcus pneumoniae develops in response to accumulation of a secreted peptide pheromone and was one of the initial examples of bacterial quorum sensing. Activation of this signaling system induces not only expression of the proteins required for transformation but also the production of cellular chaperones and proteases. We have shown here that activi ...
DOI:: 10.1128/mBio.00071-11
PubMed:: 21933920
PubMed Central:: PMC3175624
: https://doi.org/10.1128/mBio.00071-11

27. Synthetic inter-species cooperation of host and virus for targeted genetic evolution

Author:: Dokyun Na; Sunjae Lee; Gwan-Su Yi; Doheon Lee
Source:: Journal of biotechnology 2011 v.153 no.1-2 pp. 35-41
ISSN:: 0168-1656
Subject:: Escherichia coli; antibiotics; bacteriophages; biotechnology; engineering; evolution; genes; hosts; mutants; nutrients; reproduction; systems engineering
Abstract:: ... Cooperative inter-species interaction is another way of evolution in nature. Such cooperation leading to mutual benefits provides a new view on the interaction of biological systems, and engineering such inter-species interaction offers an opportunity for diverse potential applications in biotechnology. Here we show a synthetic system with artificially created inter-species cooperation of host and ...
DOI:: 10.1016/j.jbiotec.2011.03.004
: https://doi.org/10.1016/j.jbiotec.2011.03.004

28. Trade-off between growth and immune function: a meta-analysis of selection experiments

Author:: van der Most, Peter J.; de Jong, Berber; Parmentier, Henk K.; Verhulst, Simon
Source:: Functional ecology 2011 v.25 no.1 pp. 74-80
ISSN:: 0269-8463
Subject:: agricultural industry; animal breeding; animal growth; antibiotics; cell-mediated immunity; chickens; evolution; immune system; meta-analysis; turkeys
Abstract:: ... 1. Evidence suggests that developing and maintaining an effective immune system may be costly and that an organism has to make a trade-off between immune function and other fitness-enhancing traits. To test for a trade-off between growth and immune function we carried out a meta-analysis of data from lines of poultry that had been divergently selected for either growth (body mass) or an aspect of ...
DOI:: 10.1111/j.1365-2435.2010.01800.x
: https://doi.org/10.1111/j.1365-2435.2010.01800.x

29. Vibrio cholerae O1 lineages driving cholera outbreaks during seventh cholera pandemic in Ghana

Author:: Cristiane C. Thompson; Fernanda S. Freitas; Michel A. Marin; Erica L. Fonseca; Iruka N. Okeke; Ana Carolina P. Vicente
Source:: Infection, genetics, and evolution 2011 v.11 no.8 pp. 1951-1956
ISSN:: 1567-1348
Subject:: Vibrio cholerae O1; aminoglycosides; antibiotics; cholera; evolution; genes; genomic islands; genotype; multilocus sequence typing; pandemic; people; phenotype; virulence; Amazonia; Ghana
Abstract:: ... In recent years, the frequency of cholera epidemics across Africa has increased significantly with thousands of people dying each year. However, there still exists a lack of information concerning the Vibrio cholerae O1 lineages driving early and contemporary epidemics since the seventh cholera pandemic started in the continent. This compromises the understanding of the forces determining the epid ...
DOI:: 10.1016/j.meegid.2011.08.020
PubMed:: 21896336
: https://doi.org/10.1016/j.meegid.2011.08.020

30. Whole-Genome Sequencing and Phenotypic Analysis of Bacillus subtilis Mutants following Evolution under Conditions of Relaxed Selection for Sporulation

Author:: Christopher T. Brown; Laura K. Fishwick; Binna M. Chokshi; Marissa A. Cuff; Jay M. Jackson IV; Travis Oglesby; Alison T. Rioux; Enrique Rodriguez; Gregory S. Stupp; Austin H. Trupp; James S. Woollcombe-Clarke; Tracy N. Wright; William J. Zaragoza; Jennifer C. Drew; Eric W. Triplett; Wayne L. Nicholson
Source:: Applied and environmental microbiology 2011 v.77 no.19 pp. 6867-6877
ISSN:: 0099-2240
Subject:: Bacillus subtilis; DNA repair; amino acids; antibiotics; biochemical pathways; cell biology; evolution; genes; genetic variation; genomics; intergenic DNA; microarray technology; mutants; nucleotide sequences; phenotype; sequence analysis; single nucleotide polymorphism; sporulation
Abstract:: ... Little is known about how genetic variation at the nucleotide level contributes to competitive fitness within species. During a 6,000-generation study of Bacillus subtilis evolved under relaxed selection for sporulation, a new strain, designated WN716, emerged with significantly different colony and cell morphologies; loss of sporulation, competence, acetoin production, and motility; multiple auxo ...
DOI:: 10.1128/AEM.05272-11
PubMed:: 21821766
PubMed Central:: PMC3187084
: https://doi.org/10.1128/AEM.05272-11

31. Changing epidemiology of pediatric Streptococcus pneumoniae isolates before vaccine introduction in Casablanca (Morocco)

Author:: Naima Elmdaghri; Mohamed Benbachir; Houria Belabbes; Bahija Zaki; Hanane Benzaid
Source:: Vaccine 2012 v.30S6 no. pp. G46
ISSN:: 0264-410X
Subject:: Streptococcus pneumoniae; antibiotic resistance; antibiotics; children; epidemiology; evolution; monitoring; serotypes; vaccines; Morocco
Abstract:: ... The objective of this study was to describe the evolution over time of serotypes and antimicrobial resistance of Streptococcus pneumoniae isolates responsible for invasive pneumococcal disease (IPD) in children ≤5years in Casablanca (Morocco), before vaccine introduction. Isolates recovered from cases of IPD in children ≤5years during two study periods (1994–2001 and 2006–2010) were compared in te ...
DOI:: 10.1016/j.vaccine.2012.10.044
: https://doi.org/10.1016/j.vaccine.2012.10.044

32. E622, a Miniature, Virulence-Associated Mobile Element

Author:: John Stavrinides; Morgan W. B. Kirzinger; Federico C. Beasley; David S. Guttman
Source:: Journal of bacteriology 2012 v.194 no.2 pp. 509-517
ISSN:: 0021-9193
Subject:: Cyanothece; Erwinia; Nostoc; Pantoea; Pseudomonas syringae; Salmonella; Shewanella; antibiotic resistance; antibiotics; bacteria; bacteriology; enzymes; evolution; operon; surveys; terminal repeat sequences; toxins; transposons; virulence
Abstract:: ... Miniature inverted terminal repeat elements (MITEs) are nonautonomous mobile elements that have a significant impact on bacterial evolution. Here we characterize E622, a 611-bp virulence-associated MITE from Pseudomonas syringae, which contains no coding region but has almost perfect 168-bp inverted repeats. Using an antibiotic coupling assay, we show that E622 is transposable and can mobilize an ...
DOI:: 10.1128/JB.06211-11
PubMed:: 22081398
PubMed Central:: PMC3256676
: https://doi.org/10.1128/JB.06211-11

33. The Evolution of Cefotaximase Activity in the TEM β-Lactamase

Author:: Manoj Kumar Singh; Brian N. Dominy
Source:: Journal of molecular biology 2012 v.415 no.1 pp. 205-220
ISSN:: 0022-2836
Subject:: antibiotics; beta-lactamase; binding sites; catalytic activity; drug resistance; evolution; mechanics; mutants; mutation
Abstract:: ... The development of a molecular-level understanding of drug resistance through β-lactamase is critical not only in designing newer-generation antibacterial agents but also in providing insight into the evolutionary mechanisms of enzymes in general. In the present study, we have evaluated the effect of four drug resistance mutations (A42G, E104K, G238S, and M182T) on the cefotaximase activity of the ...
DOI:: 10.1016/j.jmb.2011.10.041
PubMed:: 22075446
: https://doi.org/10.1016/j.jmb.2011.10.041

34. On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient

Author:: Rutger Hermsen; J. Barrett Deris; Terence Hwa
Source:: Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.27 pp. 10775-10780
ISSN:: 0027-8424
Subject:: antibiotic resistance; antibiotics; bacteria; death; drugs; evolution; humans; models; mutants; mutation; public health; risk; stochastic processes; tissues
Abstract:: ... The rapid emergence of bacterial strains resistant to multiple antibiotics is posing a growing public health risk. The mechanisms underlying the rapid evolution of drug resistance are, however, poorly understood. The heterogeneity of the environments in which bacteria encounter antibiotic drugs could play an important role. E.g., in the highly compartmentalized human body, drug levels can vary sub ...
DOI:: 10.1073/pnas.1117716109
PubMed:: 22711808
PubMed Central:: PMC3390829
: https://doi.org/10.1073/pnas.1117716109

35. Plants as sources of new antimicrobials and resistance-modifying agents

Author:: Ana Cristina Abreu; Andrew J. McBain; Manuel Simões
Source:: Natural product reports 2012 v.29 no.9 pp. 1007-1021
ISSN:: 1460-4752
Subject:: antibiotics; drug therapy; evolution; mechanism of action; multiple drug resistance; phytochemicals; secondary metabolites
Abstract:: ... Covering: up to November 2011 Infections caused by multidrug-resistant bacteria are an increasing problem due to the emergence and propagation of microbial drug resistance and the lack of development of new antimicrobials. Traditional methods of antibiotic discovery have failed to keep pace with the evolution of resistance. Therefore, new strategies to control bacterial infections are highly desir ...
DOI:: 10.1039/c2np20035j
: https://doi.org/10.1039/c2np20035j

36. Resistance Phenotypes Mediated by Aminoacyl-Phosphatidylglycerol Synthases

Author:: Wiebke Arendt; Stefanie Hebecker; Sonja Jäger; Manfred Nimtz; Jürgen Moser
Source:: Journal of bacteriology 2012 v.194 no.6 pp. 1401-1416
ISSN:: 0021-9193
Subject:: Pseudomonas aeruginosa; alanine; amino acid sequences; aminoacylation; antibiotics; antimicrobial cationic peptides; bacteriology; beta-lactams; chimerism; enzymes; evolution; lipopeptides; lysine; mutants; phenotype; phospholipids
Abstract:: ... The specific aminoacylation of the phospholipid phosphatidylglycerol (PG) with alanine or with lysine catalyzed by aminoacyl-phosphatidylglycerol synthases (aaPGS) was shown to render various organisms less susceptible to antibacterial agents. This study makes use of Pseudomonas aeruginosa chimeric mutant strains producing lysyl-phosphatidylglycerol (L-PG) instead of the naturally occurring alanyl ...
DOI:: 10.1128/JB.06576-11
PubMed:: 22267511
PubMed Central:: PMC3294870
: https://doi.org/10.1128/JB.06576-11

37. The Role of Clonal Interference in the Evolutionary Dynamics of Plasmid-Host Adaptation

Author:: Julie M. Hughes; Brian K. Lohman; Gail E. Deckert; Eric P. Nichols; Matt Settles; Zaid Abdo; Eva M. Top
Source:: mBio 2012 v.3 no.4 pp. e00077-12
ISSN:: 2150-7511
Subject:: Shewanella oneidensis; antibiotic resistance; antibiotics; bacteria; clones; evolution; genotype; hosts; plasmids; point mutation; sequence analysis
Abstract:: ... Promiscuous plasmids replicate in a wide range of bacteria and therefore play a key role in the dissemination of various host-beneficial traits, including antibiotic resistance. Despite the medical relevance, little is known about the evolutionary dynamics through which drug resistance plasmids adapt to new hosts and thereby persist in the absence of antibiotics. We previously showed that the inco ...
DOI:: 10.1128/mBio.00077-12
PubMed:: 22761390
PubMed Central:: PMC3398533
: https://doi.org/10.1128/mBio.00077-12

38. Selection of resistance at lethal and non-lethal antibiotic concentrations

Author:: Diarmaid Hughes; Dan I Andersson
Source:: Current opinion in microbiology 2012 v.15 no.5 pp. 555-560
ISSN:: 1369-5274
Subject:: antibiotic resistance; antibiotics; bacteria; drugs; evolution; genomics; mutants; mutation; phenotype
Abstract:: ... Much of what we currently know about the genetics and evolution of antibiotic-resistance is based on selections with lethal drug concentrations that allow the detection of rare mutants with strong phenotypes. These data may be misleading with regard to the evolution of antibiotic resistance in natural environments, because bacteria are frequently exposed to concentration gradients of antibiotics. ...
DOI:: 10.1016/j.mib.2012.07.005
: https://doi.org/10.1016/j.mib.2012.07.005

39. Bacterial resistance to cationic antimicrobial peptides

Author:: José Luis Anaya-López; Joel Edmundo López-Meza; Alejandra Ochoa-Zarzosa
Source:: Critical reviews in microbiology 2013 v.39 no.2 pp. 180-195
ISSN:: 1549-7828
Subject:: antibiotic resistance; antibiotics; antimicrobial peptides; bacteria; electrostatic interactions; evolution; mechanism of action; resistance mechanisms; therapeutics; virulent strains
Abstract:: ... Naturally occurring cationic antimicrobial peptides (CAMPs) have been considered as promising candidates to treat infections caused by pathogenic bacteria to animals and humans. This assumption is based on their mechanism of action, which is mainly performed through electrostatic membrane interactions. Unfortunately, the rise in the reports that describe bacterial resistance to CAMPs has redefined ...
DOI:: 10.3109/1040841X.2012.699025
: https://doi.org/10.3109/1040841X.2012.699025

40. Co-Evolutionary Dynamics of the Bacteria Vibrio sp. CV1 and Phages V1G, V1P1, and V1P2: Implications for Phage Therapy

Author:: Camilo Barbosa; Patrick Venail; Angela V. Holguin; Martha J. Vives
Source:: Microbial ecology 2013 v.66 no.4 pp. 897-905
ISSN:: 0095-3628
Subject:: Vibrio; antibiotics; bacteria; bacterial infections; bacteriophages; evolution; food industry; hatcheries; larvae; mortality; pathogenicity; shrimp; therapeutics
Abstract:: ... Bacterial infections are the second largest cause of mortality in shrimp hatcheries. Among them, bacteria from the genus Vibrio constitute a major threat. As the use of antibiotics may be ineffective and banned from the food sector, alternatives are required. Historically, phage therapy, which is the use of bacteriophages, is thought to be a promising option to fight against bacterial infections. ...
DOI:: 10.1007/s00248-013-0284-2
PubMed:: 24013213
: https://doi.org/10.1007/s00248-013-0284-2

41. Development of a poly(ether urethane) system for the controlled release of two novel anti-biofilm agents based on gallium or zinc and its efficacy to prevent bacterial biofilm formation

Author:: Hongyan Ma; Erica T. Darmawan; Min Zhang; Lei Zhang; James D. Bryers
Source:: Journal of controlled release 2013 v.172 no.3 pp. 1035-1044
ISSN:: 0168-3659
Subject:: Pseudomonas aeruginosa; Staphylococcus epidermidis; antibiotics; bacteria; biofilm; cytotoxicity; endotoxins; ethylene glycol; evolution; gallium; in vivo studies; microbial growth; polymers; protoporphyrin; siderophores; therapeutics; urethane; zinc
Abstract:: ... Traditional antibiotic therapy to control medical device-based infections typically fails to clear biofilm infections and may even promote the evolution of antibiotic resistant species. We report here the development of two novel antibiofilm agents; gallium (Ga) or zinc (Zn) complexed with protoporphyrin IX (PP) or mesoprotoporphyrin IX (MP) that are both highly effective in negating suspended bac ...
DOI:: 10.1016/j.jconrel.2013.10.005
PubMed:: 24140747
PubMed Central:: PMC3858484
: https://doi.org/10.1016/j.jconrel.2013.10.005

42. Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3″)-Ii/AAC(6′)-IId from Serratia marcescens

Author:: Keith D. Green; Sylvie Garneau-Tsodikova
Source:: Biochimie 2013 v.95 pp. 1319-1325
ISSN:: 0300-9084
Subject:: Serratia marcescens; acetylation; aminoglycosides; antibiotics; bacteria; enteropathogens; enzymes; evolution; genes; humans; phosphorylation; resistance mechanisms
Abstract:: ... Aminoglycosides (AGs) are broad-spectrum antibiotics whose constant use and presence in growth environments has led bacteria to develop resistance mechanisms to aid in their survival. A common mechanism of resistance to AGs is their chemical modification (nucleotidylation, phosphorylation, or acetylation) by AG-modifying enzymes (AMEs). Through evolution, fusion of two AME-encoding genes has resul ...
DOI:: 10.1016/j.biochi.2013.02.011
PubMed:: 23485681
PubMed Central:: PMC3646955
: https://doi.org/10.1016/j.biochi.2013.02.011

43. Francisella noatunensis subsp. noatunensis replicates within Atlantic cod (Gadus morhua L.) leucocytes and inhibits respiratory burst activity

Author:: Nils Vestvik; Anita Rønneseth; Cathrine A.K. Kalgraff; Hanne C. Winther-Larsen; Heidrun I. Wergeland; Gyri T. Haugland
Source:: Fish & shellfish immunology 2013 v.35 no.3 pp. 725-733
ISSN:: 1050-4648
Subject:: Francisella; Gadus morhua; antibiotics; antibodies; bacteria; cod (fish); evolution; flow cytometry; fluorescence; green fluorescent protein; kidneys; macrophages; monocytes; pathogenicity; pathogens; salmon; vaccines
Abstract:: ... Francisella noatunensis subsp. noatunensis, causing granulomatosis in cod, has been shown to reside within cod immune cells, mainly within monocytes and macrophages. In the present study, we analysed the ability of the bacterium to replicate within adherent cells isolated from head kidney by in vitro infection of leucocytes. Two different technical approaches for flow cytometry analyses were perfo ...
DOI:: 10.1016/j.fsi.2013.06.002
: https://doi.org/10.1016/j.fsi.2013.06.002

44. Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian β-Lactamases

Author:: Risso Valeria A.; Gavira Jose A.; Mejia-Carmona Diego F.; Gaucher Eric A.; Sanchez-Ruiz Jose M.
Source:: Journal of the American Chemical Society 2013 v.135 no.8 pp. 2899-2902
ISSN:: 1520-5126
Subject:: X-radiation; active sites; amino acids; antibiotics; beta-lactamase; denaturation; evolution; scaffolding proteins; temperature
Abstract:: ... We report a sequence reconstruction analysis targeting several Precambrian nodes in the evolution of class-A β-lactamases and the preparation and experimental characterization of their encoded proteins. Despite extensive sequence differences with the modern enzymes (∼100 amino acid differences), the proteins resurrected in the laboratory properly fold into the canonical lactamase structure. The en ...
DOI:: 10.1021/ja311630a
: https://doi.org/10.1021/ja311630a

45. Molecular prophage typing of avian pathogenic Escherichia coli

Author:: Hyuk-Joon Kwon; Won-Jin Seong; Jae-Hong Kim
Source:: Veterinary microbiology 2013 v.162 no.2-4 pp. 785-792
ISSN:: 0378-1135
Subject:: Escherichia coli; Shigella; antibiotics; bacteriophages; birds; evolution; genes; hosts; nutrition; packaging; population structure; toxins; virulence
Abstract:: ... Escherichia coli prophages confer virulence and resistance to physico-chemical, nutritional, and antibiotic stresses on their hosts, and they enhance the evolution of E. coli. Thus, studies on profiles of E. coli prophages are valuable to understand the population structure and evolution of E. coli pathogenicity. Large terminase genes participate in phage genome packaging and are one of the corner ...
DOI:: 10.1016/j.vetmic.2012.10.005
PubMed:: 23102989
: https://doi.org/10.1016/j.vetmic.2012.10.005

46. Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE

Author:: Kallio Pauli; Patrikainen Pekka; Belogurov Georgiy A.; Mäntsälä Pekka; Yang Keqian; Niemi Jarmo; Metsä-Ketelä Mikko
Source:: Biochemistry 2013 v.52 no.26 pp. 4507-4516
ISSN:: 1520-4995
Subject:: active sites; antibiotics; biosynthesis; crystal structure; enzyme kinetics; enzymes; evolution; flavoproteins; hydroxylation; models
Abstract:: ... Two functionally distinct homologous flavoprotein hydroxylases, PgaE and JadH, have been identified as branching points in the biosynthesis of the polyketide antibiotics gaudimycin C and jadomycin A, respectively. These evolutionarily related enzymes are both bifunctional and able to catalyze the same initial reaction, C-12 hydroxylation of the common angucyclinone intermediate prejadomycin. The e ...
DOI:: 10.1021/bi400381s
: https://doi.org/10.1021/bi400381s

47. Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance

Author:: Seungsoo Kim; Tami D. Lieberman; Roy Kishony
Source:: Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.40 pp. 14494-14499
ISSN:: 0027-8424
Subject:: antibiotic resistance; antibiotics; combination drug therapy; drugs; evolution; multiple drug resistance; mutation; sequence analysis; toxicity
Abstract:: ... Alternating antibiotic therapy, in which pairs of drugs are cycled during treatment, has been suggested as a means to inhibit the evolution of de novo resistance while avoiding the toxicity associated with more traditional combination therapy. However, it remains unclear under which conditions and by what means such alternating treatments impede the evolution of resistance. Here, we tracked multis ...
DOI:: 10.1073/pnas.1409800111
PubMed:: 25246554
PubMed Central:: PMC4210010
: https://doi.org/10.1073/pnas.1409800111

48. Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus

Author:: Kayeon Lee; Jin-Hyung Lee; Soon-Il Kim; Moo Hwan Cho; Jintae Lee
Source:: Applied microbiology and biotechnology 2014 v.98 no.22 pp. 9447-9457
ISSN:: 0175-7598
Subject:: Caenorhabditis elegans; Cananga; Staphylococcus aureus; antibiotics; bacteria; biofilm; black pepper; cell viability; essential oils; evolution; gene expression regulation; hemolysis; humans; multiple drug resistance; oils; pathogens; regulator genes; screening; transcription (genetics); virulence
Abstract:: ... The long-term usage of antibiotics has resulted in the evolution of multidrug-resistant bacteria. Unlike antibiotics, anti-virulence approaches target bacterial virulence without affecting cell viability, which may be less prone to develop drug resistance. Staphylococcus aureus is a major human pathogen that produces diverse virulence factors, such as α-toxin, which is hemolytic. Also, biofilm for ...
DOI:: 10.1007/s00253-014-5903-4
PubMed:: 25027570
: https://doi.org/10.1007/s00253-014-5903-4

49. Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata

Author:: Babita Paudel; Hari Datta Bhattarai; Hong Kum Lee; Hyuncheol Oh; Hyun Woung Shin; Joung Han Yim
Source:: Zeitschrift für Naturforschung 2014 v.65 no.1-2 pp. 34-38
ISSN:: 1865-7125
Subject:: Bacillus subtilis; Ramalina; Staphylococcus aureus; antibacterial properties; antibiotics; bacteria; chromatography; disk diffusion antimicrobial test; drugs; evolution; lichens; methanol; minimum inhibitory concentration; usnic acid; Antarctic region
Abstract:: ... The development of new antibacterial compounds is an urgent issue to meet the evolution of resistivity of pathogenic bacteria against the available drugs. The objective of this study was to investigate the antibacterial compounds from the Antarctic lichen species Ramalina terebrata. A total of fi ve compounds, usnic acid, usimine A, usimine B, usimine C, and ramalin, were isolated by bioactivity g ...
DOI:: 10.1515/znc-2010-1-206
: https://doi.org/10.1515/znc-2010-1-206

50. Antibiotic-Induced Replication Stress Triggers Bacterial Competence by Increasing Gene Dosage near the Origin

Author:: Jelle Slager; Morten Kjos; Laetitia Attaiech; Jan-Willem Veening
Source:: Cell 2014 v.157 pp. 395-406
ISSN:: 0092-8674
Subject:: DNA; DNA replication; Streptococcus pneumoniae; antibiotic resistance; antibiotics; bacteria; children; evolution; gene dosage; gene expression; genes; human health; replication origin; transcriptome
Abstract:: ... Streptococcus pneumoniae (pneumococcus) kills nearly 1 million children annually, and the emergence of antibiotic-resistant strains poses a serious threat to human health. Because pneumococci can take up DNA from their environment by a process called competence, genes associated with antibiotic resistance can rapidly spread. Remarkably, competence is activated in response to several antibiotics. H ...
DOI:: 10.1016/j.cell.2014.01.068
: https://doi.org/10.1016/j.cell.2014.01.068

51. Epidemiology of asexuality induced by the endosymbiotic Wolbachia across phytophagous wasp species: host plant specialization matters

Author:: T. Boivin; H. Henri; F. Vavre; C. Gidoin; P. Veber; J.‐N. Candau; E. Magnoux; A. Roques; M.‐A. Auger‐Rozenberg
Source:: Molecular ecology 2014 v.23 no.9 pp. 2362-2375
ISSN:: 0962-1083
Subject:: arrhenotoky; insects; Vespidae; Rickettsia; sex ratio; thelytoky; screening; females; Megastigmus; Wolbachia; community structure; evolution; host plants; hybridization; mutation; insect communities; epidemiology; Arsenophonus; antibiotics; endosymbionts; surveys
Abstract:: ... Among eukaryotes, sexual reproduction is by far the most predominant mode of reproduction. However, some systems maintaining sexuality appear particularly labile and raise intriguing questions on the evolutionary routes to asexuality. Thelytokous parthenogenesis is a form of spontaneous loss of sexuality leading to strong distortion of sex ratio towards females and resulting from mutation, hybridi ...
DOI:: 10.1111/mec.12737
PubMed:: 24673824
: https://doi.org/10.1111/mec.12737

52. Evolution of Resistance to Quorum-Sensing Inhibitors

Author:: Vipin C. Kalia; Thomas K. Wood; Prasun Kumar
Source:: Microbial ecology 2014 v.68 no.1 pp. 13-23
ISSN:: 0095-3628
Subject:: antibiotics; bacteria; bacterial infections; evolution; humans; microbial growth; morbidity; mortality; pathogenicity; pathogens; quorum sensing; receptors
Abstract:: ... The major cause of mortality and morbidity in human beings is bacterial infection. Bacteria have developed resistance to most of the antibiotics primarily due to large-scale and “indiscriminate” usage. The need is to develop novel mechanisms to treat bacterial infections. The expression of pathogenicity during bacterial infections is mediated by a cell density-dependent phenomenon known as quorum ...
DOI:: 10.1007/s00248-013-0316-y
PubMed:: 24194099
PubMed Central:: PMC4012018 [Available on 07/01/15]
: https://doi.org/10.1007/s00248-013-0316-y

53. Evolution of extensively drug-resistant Mycobacterium tuberculosis from a susceptible ancestor in a single patient

Author:: Vegard Eldholm; Gunnstein Norheim; Bent von der Lippe; Wibeke Kinander; Ulf R Dahle; Dominique A Caugant; Turid Mannsåker; Anne Torunn Mengshoel; Anne Ma Dyrhol-Riise; Francois Balloux
Source:: Genome biology 2014 v.15 no.11 pp. 490
ISSN:: 1474-760X
Subject:: Mycobacterium tuberculosis; antibiotic resistance; antibiotics; clones; drugs; evolution; gene expression; gene expression regulation; genetic background; genetic recombination; nucleotide sequences; operon; patients; single nucleotide polymorphism; tuberculosis
Abstract:: ... BACKGROUND: Mycobacterium tuberculosis is characterized by a low mutation rate and a lack of genetic recombination. Yet, the rise of extensively resistant strains paints a picture of a microbe with an impressive adaptive potential. Here we describe the first documented case of extensively drug-resistant tuberculosis evolved from a susceptible ancestor within a single patient. RESULTS: Genome seque ...
DOI:: 10.1186/s13059-014-0490-3
PubMed:: 25418686
PubMed Central:: PMC4223161
: https://doi.org/10.1186/s13059-014-0490-3

54. Gene networks regulating secondary metabolism in actinomycetes: Pleiotropic regulators

Author:: M. V. Rabyk; B. O. Ostash; V. O. Fedorenko
Source:: Cytology and genetics 2014 v.48 no.1 pp. 55-67
ISSN:: 0095-4527
Subject:: Actinomycetales; antibiotics; bacteria; biosynthesis; evolution; gene expression; genetic engineering; metabolic engineering; metabolome; morphogenesis; operon; regulator genes; screening
Abstract:: ... Current advances in the research and practical application of pleiotropic regulatory genes for antibiotic production in actinomycetes are reviewed. The basic regulatory mechanisms discovered in these bacteria are outlined. The examples described in the review show the importance of the manipulation of regulatory systems that affect the synthesis of antibiotics for the metabolic engineering of acti ...
DOI:: 10.3103/S0095452714010083
: https://doi.org/10.3103/S0095452714010083

55. An Indigenous Gut Bacterium, Enterococcus faecalis (Lactobacillales: Enterococcaceae), Increases Seed Consumption By Harpalus pensylvanicus (Coleoptera: Carabidae)

Author:: Schmid Ryan B.; Lehman R. Michael; Brözel Volker S.; Lundgren Jonathan G.
Source:: Florida entomologist 2014 v.97 no.2 pp. 575-584
ISSN:: 0015-4040
Subject:: Enterococcus faecalis; Harpalus; animals; antibiotics; biomass; diet; digestion; digestive enzymes; evolution; food webs; herbivores; insects; intestinal microorganisms; intestines; microsymbionts; seed predation; seeds; symbiosis
Abstract:: ... Microbial symbioses likely drive the evolution of diet within animals, yet these symbiotic relationships remain poorly understood for many organisms. The bacterial endosymbiont Enterococcus faecalis is found in the intestinal tract of the beetle Harpalus pensylvanicus (DeGeer) (Coleoptera: Carabidae) and is thought to contribute to the digestion of the insect's seed diet. We tested whether E. faec ...
DOI:: 10.1896/054.097.0232
: https://doi.org/10.1896/054.097.0232

56. Insights on evolution of virulence and resistance from the whole-genome analysis of a predominant methicillin-resistant Staphylococcus aureus clone sequence type 239 in China

Author:: Hongbin Chen; Xi Yang; Qi Wang; Chunjiang Zhao; Henan Li; Wenqiang He; Xiaojuan Wang; Feifei Zhang; Zhanwei Wang; Minjun Chen; Baoli Zhu; Hui Wang
Source:: Chinese science bulletin 2014 v.59 no.11 pp. 1104-1112
ISSN:: 1001-6538
Subject:: Staphylococcus aureus; antibiotic resistance; antibiotics; beta-lactamase; blood; databases; evolution; genes; genomic islands; genomics; humans; immune system; transposons; virulence; China
Abstract:: ... Earlier, we reported that ST239 was the 15-year predominant methicillin-resistant Staphylococcus aureus (MRSA) clone in China. In this study, MRSA strain CN79 belonging to ST239 and isolated from blood was used to determine the whole genome sequence. Comparative genomics analysis was done between MRSA CN79 and 25 sequenced S. aureus in the NCBI GenBank database. A total of 2,734 protein-encoding g ...
DOI:: 10.1007/s11434-014-0149-1
: https://doi.org/10.1007/s11434-014-0149-1

57. Molecular evolution of the bacterial pseudouridine‐5′‐phosphate glycosidase protein family

Author:: Keshav Thapa; Terhi Oja; Mikko Metsä‐Ketelä
Source:: FEBS journal 2014 v.281 no.19 pp. 4439-4449
ISSN:: 1742-464X
Subject:: Escherichia coli; RNA; Streptomyces albus; amino acid sequences; antibiotics; bioinformatics; biosynthesis; evolution; genes; glycosidases; horizontal gene transfer; juglone; ligases; loci; phosphorylation; pigments
Abstract:: ... Pseudouridine is a noncanonical C–nucleoside commonly present in RNA, which is not metabolized in mammals, but can be recycled by the unique enzyme family of bacterial pseudouridine glycosidases such as YeiN from Escherichia coli. Here, we present rigorous bioinformatic and biochemical analyses of the protein family in order to find sequences that might code for nonpseudouridine glycosidase activi ...
DOI:: 10.1111/febs.12950
: https://doi.org/10.1111/febs.12950

58. Morphological optimization for access to dual oxidants in biofilms

Author:: Christopher P. Kempes; Chinweike Okegbe; Zwoisaint Mears-Clarke; Michael J. Follows; Lars E. P. Dietrich
Source:: Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.1 pp. 208-213
ISSN:: 0027-8424
Subject:: Pseudomonas aeruginosa; antibiotics; bacteria; biofilm; evolution; genetic engineering; mathematical models; oxidants; oxygen; phenazines; reproduction
Abstract:: ... A major theme driving research in biology is the relationship between form and function. In particular, a longstanding goal has been to understand how the evolution of multicellularity conferred fitness advantages. Here we show that biofilms of the bacterium Pseudomonas aeruginosa produce structures that maximize cellular reproduction. Specifically, we develop a mathematical model of resource avai ...
DOI:: 10.1073/pnas.1315521110
PubMed:: 24335705
PubMed Central:: PMC3890773
: https://doi.org/10.1073/pnas.1315521110

59. NP/MS since 1970: from the basement to the bench top

Author:: Guy T. Carter
Source:: Natural product reports 2014 v.31 no.6 pp. 711-717
ISSN:: 1460-4752
Subject:: antibiotics; evolution; ions; mass spectrometry; technology
Abstract:: ... This Highlight explores the evolution of applications of mass spectrometric technologies in the context of natural products research since the 1970's. The central themes are the analysis of mixtures, dereplication (identification) and structure determination. The ascension of HPLC as the method of choice for the analysis of pharmaceuticals was a driving force for the development of interfaces for ...
DOI:: 10.1039/c3np70085b
: https://doi.org/10.1039/c3np70085b

60. Natural solution to antibiotic resistance: bacteriophages ‘The Living Drugs’

Author:: Sabah A. A. Jassim; Richard G. Limoges
Source:: World journal of microbiology & biotechnology 2014 v.30 no.8 pp. 2153-2170
ISSN:: 0959-3993
Subject:: animal husbandry; antibiotic resistance; antibiotics; bacteria; bacteriophages; biological control; evolution; farmed animal species; humans; pathogens; therapeutics; therapy animals
Abstract:: ... Antibiotics have been a panacea in animal husbandry as well as in human therapy for decades. The huge amount of antibiotics used to induce the growth and protect the health of farm animals has lead to the evolution of bacteria that are resistant to the drug’s effects. Today, many researchers are working with bacteriophages (phages) as an alternative to antibiotics in the control of pathogens for h ...
DOI:: 10.1007/s11274-014-1655-7
PubMed:: 24781265
PubMed Central:: PMC4072922
: https://doi.org/10.1007/s11274-014-1655-7

61. Oxidative stress response in Pseudomonas putida

Author:: Jisun Kim; Woojun Park
Source:: Applied microbiology and biotechnology 2014 v.98 no.16 pp. 6933-6946
ISSN:: 0175-7598
Subject:: Escherichia coli; Pseudomonas putida; Salmonella; antibiotics; cell viability; defense mechanisms; enzymes; evolution; homeostasis; niches; organic compounds; oxidation; oxidative stress; proteins; reactive oxygen species; regulon; soil bacteria; stress response; transcription (genetics)
Abstract:: ... Pseudomonas putida is widely distributed in nature and is capable of degrading various organic compounds due to its high metabolic versatility. The survival capacity of P. putida stems from its frequent exposure to various endogenous and exogenous oxidative stresses. Oxidative stress is an unavoidable consequence of interactions with various reactive oxygen species (ROS)-inducing agents existing i ...
DOI:: 10.1007/s00253-014-5883-4
PubMed:: 24957251
: https://doi.org/10.1007/s00253-014-5883-4

62. Sanitizing the fortress: protection of ant brood and nest material by worker antibiotics

Author:: C. Tranter; P. Graystock; C. Shaw; J. F. S. Lopes; W. O. H. Hughes
Source:: Behavioral ecology and sociobiology 2014 v.68 no.3 pp. 499-507
ISSN:: 0340-5443
Subject:: Aspergillus; Formicidae; Metarhizium; antibiotics; evolution; fungi; genetic variation; larvae; leaf-cutting ants; nests; parasites; risk; sanitizing; sporulation
Abstract:: ... Social groups are at particular risk for parasite infection, which is heightened in eusocial insects by the low genetic diversity of individuals within a colony. To combat this, adult ants have evolved a suite of defenses to protect each other, including the production of antimicrobial secretions. However, it is the brood in a colony that are most vulnerable to parasites because their individual d ...
DOI:: 10.1007/s00265-013-1664-9
: https://doi.org/10.1007/s00265-013-1664-9

63. Staphylococcus aureus Alters Growth Activity, Autolysis, and Antibiotic Tolerance in a Human Host-Adapted Pseudomonas aeruginosa Lineage

Author:: Charlotte Frydenlund Michelsen; Anne-Mette Juel Christensen; Martin Saxtorph Bojer; Niels Høiby; Hanne Ingmer; Lars Jelsbak
Source:: Journal of bacteriology 2014 v.196 no.22 pp. 3903-3911
ISSN:: 0021-9193
Subject:: Pseudomonas aeruginosa; Staphylococcus aureus; agar; antibiotics; autolysis; bacteriology; coculture; cystic fibrosis; evolution; flora; hosts; humans; pathogens; patients; proteinases; proteins; proteolysis; quorum sensing; transcription (genetics); virulence
Abstract:: ... Interactions among members of polymicrobial infections or between pathogens and the commensal flora may determine disease outcomes. Pseudomonas aeruginosa and Staphylococcus aureus are important opportunistic human pathogens and are both part of the polymicrobial infection communities in human hosts. In this study, we analyzed the in vitro interaction between S. aureus and a collection of P. aerug ...
DOI:: 10.1128/JB.02006-14
PubMed:: 25182495
PubMed Central:: PMC4248816
: https://doi.org/10.1128/JB.02006-14

64. Widening the Spaces of Selection: Evolution along Sublethal Antimicrobial Gradients

Author:: Fernando Baquero; Teresa M. Coque
Source:: mBio 2014 v.5 no.6 pp. e02270-14
ISSN:: 2150-7511
Subject:: antibiotics; bacteria; evolution; heavy metals; metal tolerance; plasmids; sewage; surface water
Abstract:: ... The work of Gullberg et al. (E. Gullberg, L. M. Albrecht, C. Karlsson, L. Sandegren, D. I. Andersson, mBio 5:e01918-14, 2014) indicates that extremely low concentrations of antibiotics and heavy metals are able to compensate for the cost of harboring a plasmid encoding resistances to these inhibitors. Therefore, the “spaces of selection” for plasmids encoding antibiotic or metal resistance along g ...
DOI:: 10.1128/mBio.02270-14
PubMed:: 25491358
PubMed Central:: PMC4324248
: https://doi.org/10.1128/mBio.02270-14

65. The agriciultural antibiotic carbadox induces phage-mediated gene transfer in Salmonella

Author:: Bradley L. Bearson; Health K. Allen; Brian W. Brunelle; In Soo Lee; Sherwood R. Casjens; Thaddeus B. Stanton
Source:: Frontiers in microbiology 2014 v.5 no. pp. 1-8
ISSN:: 2371-9818
Subject:: Shiga toxin; genetic transduction; swine dysentery; Salmonella Typhimurium; bacteriophages; plasmids; animal production; genes; Shiga toxin-producing Escherichia coli; multiple drug resistance; gene expression regulation; virulence; carbadox; humans; evolution; electron microscopy; feed conversion; hosts; adverse effects; swine; gene transfer; virion; antibiotic resistance; antibiotics; food pathogens; enteritis; Brachyspira hyodysenteriae; bacteria; United States
Abstract:: ... Antibiotics are used for their disease therapeutic or preventative effects in humans and animals, as well as for enhanced feed conversion efficiency in livestock. Antibiotics can also cause undesirable effects in microbial populations, including selection for antibiotic resistance, enhanced pathogen invasion, and stimulation of horizontal gene transfer. Carbadox is a veterinary antibiotic used in ...
Handle:: 10113/58432
DOI:: 10.3389/fmicb.2014.00052
PubMed:: 24575089
PubMed Central:: PMC3920066
: https://doi.org/10.3389/fmicb.2014.00052

66. Activation of the σᴱ-Dependent Stress Pathway by Conjugative TraR May Anticipate Conjugational Stress

Author:: Elicia D. Grace; Saumya Gopalkrishnan; Mary E. Girard; Matthew D. Blankschien; Wilma Ross; Richard L. Gourse; Christophe Herman
Source:: Journal of bacteriology 2015 v.197 no.5 pp. 924-931
ISSN:: 0021-9193
Subject:: DNA-directed RNA polymerase; Escherichia coli; antibiotic resistance; antibiotics; bacteria; biosynthesis; evolution; fimbriae; horizontal gene transfer; pathogens; plasmids; protein folding; proteinases; signal transduction; stress response; virulence
Abstract:: ... Horizontal gene transfer by conjugation plays a major role in bacterial evolution, allowing the acquisition of new traits, such as virulence and resistance to antibacterial agents. With the increased antibiotic resistance in bacterial pathogens, a better understanding of how bacteria modulate conjugation under changing environments and the genetic factors involved is needed. Despite the evolutiona ...
DOI:: 10.1128/JB.02279-14
PubMed:: 25535270
PubMed Central:: PMC4325106
: https://doi.org/10.1128/JB.02279-14

67. Antimicrobial interactions: mechanisms and implications for drug discovery and resistance evolution

Author:: Tobias Bollenbach
Source:: Current opinion in microbiology 2015 v.27 pp. 1-9
ISSN:: 1369-5274
Subject:: antibiotics; cell physiology; combination drug therapy; drug interactions; drugs; evolution; prediction
Abstract:: ... Combining antibiotics is a promising strategy for increasing treatment efficacy and for controlling resistance evolution. When drugs are combined, their effects on cells may be amplified or weakened, that is the drugs may show synergistic or antagonistic interactions. Recent work revealed the underlying mechanisms of such drug interactions by elucidating the drugs’ joint effects on cell physiology ...
DOI:: 10.1016/j.mib.2015.05.008
: https://doi.org/10.1016/j.mib.2015.05.008

68. Cold-adapted bacteria from a coastal area of the Ross Sea (Terra Nova Bay, Antarctica): linking microbial ecology to biotechnology

Author:: Angelina Lo Giudice; Renato Fani
Source:: Hydrobiologia 2015 v.761 no.1 pp. 417-441
ISSN:: 0018-8158
Subject:: sediments; bioactive properties; antibiotics; evolution; heavy metals; humans; biotechnology; biochemical pathways; environmental factors; polychlorinated biphenyls; seawater; secondary metabolites; bacterial communities; anthropogenic activities; coasts; temperature; bacteria; Antarctica; Antarctic region
Abstract:: ... This review covers available information concerning the bacterial communities inhabiting coastal areas of Terra Nova Bay (Antarctica). Research was mainly focused on seawater, sediment, and benthic filter feeders. Coping with adverse environmental conditions, Antarctic bacteria have evolved peculiar strategies to survive in this harsh environment. In addition to cellular modifications, antagonisti ...
DOI:: 10.1007/s10750-015-2497-5
: https://doi.org/10.1007/s10750-015-2497-5

69. Collateral sensitivity of antibiotic-resistant microbes

Author:: Csaba Pál; Balázs Papp; Viktória Lázár
Source:: Trends in microbiology 2015 v.23 no.7 pp. 401-407
ISSN:: 0966-842X
Subject:: antibiotic resistance; antibiotics; bacteria; drugs; evolution; multiple drug resistance; mutation; resistance mechanisms; sequence analysis
Abstract:: ... Understanding how evolution of microbial resistance towards a given antibiotic influences susceptibility to other drugs is a challenge of profound importance. By combining laboratory evolution, genome sequencing, and functional analyses, recent works have charted the map of evolutionary trade-offs between antibiotics and have explored the underlying molecular mechanisms. Strikingly, mutations that ...
DOI:: 10.1016/j.tim.2015.02.009
PubMed:: 25818802
PubMed Central:: PMC5958998
: https://doi.org/10.1016/j.tim.2015.02.009

70. Comparative morpho-physiology of the metapleural glands of two Atta leaf-cutting ant queens nesting in clayish and organic soils

Author:: Alexsandro Santana Vieira; Maria Izabel Camargo-Mathias; Flavio Roces
Source:: Arthropod structure & development 2015 v.44 no.5 pp. 444-454
ISSN:: 1467-8039
Subject:: Atta sexdens rubropilosa; antibiotics; antiseptics; evolution; fungus gardens; leaf-cutting ants; microorganisms; nesting; organic matter; organic soils; pathogens; queen insects; risk; soil depth; soil horizons
Abstract:: ... Queens of leaf-cutting ants found their nests singly, each consisting of a vertical tunnel and a final horizontal chamber. Because of the claustral mode of nest founding, the queen and/or her initial fungus garden are exposed to threats imposed by several soil pathogens, and the antibiotic secretions produced by their metapleural glands are considered a main adaptation to deal with them. Nests of ...
DOI:: 10.1016/j.asd.2015.06.005
: https://doi.org/10.1016/j.asd.2015.06.005

71. Cysteine-stabilized αβ defensins: From a common fold to antibacterial activity

Author:: Renata de Oliveira Dias; Octavio Luiz Franco
Source:: Peptides 2015 v.72 pp. 64-72
ISSN:: 0196-9781
Subject:: amino acids; antibacterial properties; antibiotics; antimicrobial peptides; bacteria; disulfide bonds; evolution; fungi; invertebrates; mechanism of action
Abstract:: ... Antimicrobial peptides (AMPs) seem to be promising alternatives to common antibiotics, which are facing increasing bacterial resistance. Among them are the cysteine-stabilized αβ defensins. These peptides are small, with a length ranging from 34 to 54 amino acid residues, cysteine-rich and extremely stable, normally composed of an α-helix and three β-strands stabilized by three or four disulfide b ...
DOI:: 10.1016/j.peptides.2015.04.017
: https://doi.org/10.1016/j.peptides.2015.04.017

72. Exploring the potential impact of an expanded genetic code on protein function

Author:: Han Xiao; Fariborz Nasertorabi; Sei-hyun Choi; Gye Won Han; Sean A. Reed; Raymond C. Stevens; Peter G. Schultz
Source:: Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.22 pp. 6961-6966
ISSN:: 0027-8424
Subject:: amino acids; antibiotics; beta-lactamase; catalytic activity; evolution; genetic code; mutants; mutation
Abstract:: ... With few exceptions, all living organisms encode the same 20 canonical amino acids; however, it remains an open question whether organisms with additional amino acids beyond the common 20 might have an evolutionary advantage. Here, we begin to test that notion by making a large library of mutant enzymes in which 10 structurally distinct noncanonical amino acids were substituted at single sites ran ...
DOI:: 10.1073/pnas.1507741112
PubMed:: 26038548
PubMed Central:: PMC4460475
: https://doi.org/10.1073/pnas.1507741112

73. Extrachromosomal and integrated genetic elements in Clostridium difficile

Author:: Jacob Amy; Priscilla Johanesen; Dena Lyras
Source:: Plasmid 2015 v.80 pp. 97-110
ISSN:: 0147-619X
Subject:: Clostridium difficile; antibiotic resistance; antibiotics; bacteria; cross infection; digestive system diseases; evolution; interspersed repetitive sequences; pathogens; patients; phenotype; plasmids; sequence analysis; therapeutics
Abstract:: ... Clostridium difficile is a major nosocomial pathogen, causing gastrointestinal disease in patients undergoing antibiotic therapy. This bacterium contains many extrachromosomal and integrated genetic elements, with recent genomic work giving new insights into their variability and distribution. This review summarises research conducted in this area over the last 30 years and includes a discussion o ...
DOI:: 10.1016/j.plasmid.2015.04.006
: https://doi.org/10.1016/j.plasmid.2015.04.006

74. Fitness trade‐offs explain low levels of persister cells in the opportunistic pathogen Pseudomonas aeruginosa

Author:: Kristine Stepanyan; Tom Wenseleers; Edgar A. Duéñez‐Guzmán; Frédéric Muratori; Bram Van den Bergh; Natalie Verstraeten; Luc De Meester; Kevin J. Verstrepen; Maarten Fauvart; Jan Michiels
Source:: Molecular ecology 2015 v.24 no.7 pp. 1572-1583
ISSN:: 0962-1083
Subject:: Pseudomonas aeruginosa; antibiotics; evolution; humans; infectious diseases; models; pathogens
Abstract:: ... Microbial populations often contain a fraction of slow‐growing persister cells that withstand antibiotics and other stress factors. Current theoretical models predict that persistence levels should reflect a stable state in which the survival advantage of persisters under adverse conditions is balanced with the direct growth cost impaired under favourable growth conditions, caused by the nonreplic ...
DOI:: 10.1111/mec.13127
: https://doi.org/10.1111/mec.13127

75. Insertion Sequence IS26 Reorganizes Plasmids in Clinically Isolated Multidrug-Resistant Bacteria by Replicative Transposition

Author:: Susu He; Alison Burgess Hickman; Alessandro M. Varani; Patricia Siguier; Michael Chandler; John P. Dekker; Fred Dyda
Source:: mBio 2015 v.6 no.3 pp. e00762-15
ISSN:: 2150-7511
Subject:: Enterobacteriaceae; National Institutes of Health; antibiotic resistance; antibiotics; bacteria; beta-lactamase; evolution; genes; monitoring; multiple drug resistance; phenotype; plasmids; public health; replicon; transposition (genetics); transposons
Abstract:: ... Carbapenemase-producing Enterobacteriaceae (CPE), which are resistant to most or all known antibiotics, constitute a global threat to public health. Transposable elements are often associated with antibiotic resistance determinants, suggesting a role in the emergence of resistance. One insertion sequence, IS 26 , is frequently associated with resistance determinants, but its role remains unclear. ...
DOI:: 10.1128/mBio.00762-15
PubMed:: 26060276
PubMed Central:: PMC4471558
: https://doi.org/10.1128/mBio.00762-15

76. Mechanisms and impact of genetic recombination in the evolution of Streptococcus pneumoniae

Author:: Chrispin Chaguza; Jennifer E. Cornick; Dean B. Everett
Source:: Computational and Structural Biotechnology Journal 2015 v.13 pp. 241-247
ISSN:: 2001-0370
Subject:: DNA; Streptococcus pneumoniae; adaptive immunity; antibiotics; bacteria; evolution; genetic recombination; genetic variation; genome; mutation; population genetics; therapeutics; vaccines
Abstract:: ... Streptococcus pneumoniae (the pneumococcus) is a highly recombinogenic bacterium responsible for a high burden of human disease globally. Genetic recombination, a process in which exogenous DNA is acquired and incorporated into its genome, is a key evolutionary mechanism employed by the pneumococcus to rapidly adapt to selective pressures. The rate at which the pneumococcus acquires genetic variat ...
DOI:: 10.1016/j.csbj.2015.03.007
PubMed:: 25904996
PubMed Central:: PMC4404416
: https://doi.org/10.1016/j.csbj.2015.03.007

77. Mechanisms of genome evolution of Streptococcus

Author:: Cheryl P. Andam; William P. Hanage
Source:: Infection, genetics, and evolution 2015 v.33 pp. 334-342
ISSN:: 1567-1348
Subject:: Streptococcus pneumoniae; antibiotic resistance; antibiotics; disease control; evolution; genes; genomics; horizontal gene transfer; hosts; humans; pathogenicity; pathogens; phenotypic variation; population dynamics; respiratory system; serotypes; vaccines
Abstract:: ... The genus Streptococcus contains 104 recognized species, many of which are associated with human or animal hosts. A globally prevalent human pathogen in this group is Streptococcus pneumoniae (the pneumococcus). While being a common resident of the upper respiratory tract, it is also a major cause of otitis media, pneumonia, bacteremia and meningitis, accounting for a high burden of morbidity and ...
DOI:: 10.1016/j.meegid.2014.11.007
PubMed:: 25461843
PubMed Central:: PMC4430445
: https://doi.org/10.1016/j.meegid.2014.11.007

78. Microbial Consortium Associated with the Antarctic Marine Ciliate Euplotes focardii: An Investigation from Genomic Sequences

Author:: Sandra Pucciarelli; Raghul Rajan Devaraj; Alessio Mancini; Patrizia Ballarini; Michele Castelli; Martina Schrallhammer; Giulio Petroni; Cristina Miceli
Source:: Microbial ecology 2015 v.70 no.2 pp. 484-497
ISSN:: 0095-3628
Subject:: Francisella; antibiotics; antifreeze proteins; bacteria; cell division; cold; energy; enzymes; evolution; genes; metabolism; nucleotide sequences; Antarctic region; Antarctica
Abstract:: ... We report the characterization of the bacterial consortium associated to Euplotes focardii, a strictly psychrophilic marine ciliate that was maintained in laboratory cultures at 4 °C after its first isolation from Terra Nova Bay, in Antarctica. By Illumina genome analyser, we obtained 11,179 contigs of potential prokaryotic origin and classified them according to the NCBI’s prokaryotic attributes ...
DOI:: 10.1007/s00248-015-0568-9
PubMed:: 25704316
PubMed Central:: PMC4494151
: https://doi.org/10.1007/s00248-015-0568-9

79. Suppression of antibiotic resistance acquisition by combined use of antibiotics

Author:: Shingo Suzuki; Takaaki Horinouchi; Chikara Furusawa
Source:: Journal of bioscience and bioengineering 2015 v.120 no.4 pp. 467-469
ISSN:: 1389-1723
Subject:: antibiotic resistance; antibiotics; drugs; evolution
Abstract:: ... We analyzed the effect of combinatorial use of antibiotics with a trade-off relationship of resistance, i.e., resistance acquisition to one drug causes susceptibility to the other drug, and vice versa, on the evolution of antibiotic resistance. We demonstrated that this combinatorial use of antibiotics significantly suppressed the acquisition of resistance. ...
DOI:: 10.1016/j.jbiosc.2015.02.003
: https://doi.org/10.1016/j.jbiosc.2015.02.003

80. Targets for Combating the Evolution of Acquired Antibiotic Resistance

Author:: Culyba Matthew J.; Mo Charlie Y.; Kohli Rahul M.
Source:: Biochemistry 2015 v.54 no.23 pp. 3573-3582
ISSN:: 1520-4995
Subject:: antibiotic resistance; antibiotics; bacteria; biochemistry; drugs; evolution; horizontal gene transfer; pathogens; viability
Abstract:: ... Bacteria possess a remarkable ability to rapidly adapt and evolve in response to antibiotics. Acquired antibiotic resistance can arise by multiple mechanisms but commonly involves altering the target site of the drug, enzymatically inactivating the drug, or preventing the drug from accessing its target. These mechanisms involve new genetic changes in the pathogen leading to heritable resistance. T ...
DOI:: 10.1021/acs.biochem.5b00109
PubMed:: 26016604
PubMed Central:: PMC4471857
: https://doi.org/10.1021/acs.biochem.5b00109

81. Tn6026 and Tn6029 are found in complex resistance regions mobilised by diverse plasmids and chromosomal islands in multiple antibiotic resistant Enterobacteriaceae

Author:: Cameron J. Reid; Piklu Roy Chowdhury; Steven P. Djordjevic
Source:: Plasmid 2015 v.80 pp. 127-137
ISSN:: 0147-619X
Subject:: Escherichia coli; Salmonella enterica; antibiotic resistance; antibiotics; evolution; genes; multiple drug resistance; pathogens; plasmids; serotypes; transposons; virulence
Abstract:: ... Transposons flanked by direct copies of IS26 are important contributors to the evolution of multiple antibiotic resistance. Tn6029 and Tn6026 are examples of composite transposons that have become widely disseminated on small and large plasmids with different incompatibility markers in pathogenic and commensal Escherichia coli and various serovars of Salmonella enterica. Some of the plasmids that ...
DOI:: 10.1016/j.plasmid.2015.04.005
: https://doi.org/10.1016/j.plasmid.2015.04.005

82. Using Genome-scale Models to Predict Biological Capabilities

Author:: Edward J. O’Brien; Jonathan M. Monk; Bernhard O. Palsson
Source:: Cell 2015 v.161 pp. 971-987
ISSN:: 0092-8674
Subject:: antibiotics; evolution; genes; metabolic engineering; models
Abstract:: ... Constraint-based reconstruction and analysis (COBRA) methods at the genome scale have been under development since the first whole-genome sequences appeared in the mid-1990s. A few years ago, this approach began to demonstrate the ability to predict a range of cellular functions, including cellular growth capabilities on various substrates and the effect of gene knockouts at the genome scale. Thus ...
DOI:: 10.1016/j.cell.2015.05.019
PubMed:: 26000478
PubMed Central:: PMC4451052
: https://doi.org/10.1016/j.cell.2015.05.019

83. A genomic island integrated into recA of Vibrio cholerae contains a divergent recA and provides multi‐pathway protection from DNA damage

Author:: Rita A. Rapa; Atiqul Islam; Leigh G. Monahan; Ankur Mutreja; Nicholas Thomson; Ian G. Charles; Harold W. Stokes; Maurizio Labbate
Source:: Environmental microbiology 2015 v.17 no.4 pp. 1090-1102
ISSN:: 1462-2912
Subject:: DNA; DNA damage; DNA repair; Escherichia coli; Vibrio cholerae; adhesins; antibiotics; bacteriophages; cholera; cholera toxin; evolution; genes; genomic islands; horizontal gene transfer; pathogens; toxigenic strains; virulence
Abstract:: ... Lateral gene transfer (LGT) has been crucial in the evolution of the cholera pathogen, Vibrio cholerae. The two major virulence factors are present on two different mobile genetic elements, a bacteriophage containing the cholera toxin genes and a genomic island (GI) containing the intestinal adhesin genes. Non‐toxigenic V. cholerae in the aquatic environment are a major source of novel DNA that al ...
DOI:: 10.1111/1462-2920.12512
PubMed:: 24889424
PubMed Central:: PMC4405046
: https://doi.org/10.1111/1462-2920.12512

84. Antibiotic Adjuvants: Rescuing Antibiotics from Resistance

Author:: Gerard D. Wright
Source:: Trends in microbiology 2016 v.24 no.11 pp. 862-871
ISSN:: 0966-842X
Subject:: adjuvants; antibacterial properties; antibiotic resistance; antibiotics; drugs; evolution; mechanism of action; pathogens
Abstract:: ... Rooted in the mechanism of action of antibiotics and subject to bacterial evolution, antibiotic resistance is difficult and perhaps impossible to overcome. Nevertheless, strategies can be used to minimize the emergence and impact of resistance. Antibiotic adjuvants offer one such approach. These are compounds that have little or no antibiotic activity themselves but act to block resistance or othe ...
DOI:: 10.1016/j.tim.2016.06.009
: https://doi.org/10.1016/j.tim.2016.06.009

85. Antibiotics and evolution: food for thought

Author:: C. R. Strachan; J. Davies
Source:: Journal of industrial microbiology & biotechnology 2016 v.43 no.2-3 pp. 149-153
ISSN:: 1367-5435
Subject:: antibiotics; evolution; molecular weight; polymerization; polypeptides; receptors; secondary metabolites
Abstract:: ... The role of secondary metabolites in effecting and modulating reactions during early biochemical evolution has been largely unappreciated. It is possible that low molecular weight effectors were gradually replaced by polypeptides as polymerizing reactions became more complex, but retained some ability to interact with original receptor sites. Indeed, by reviewing the era of antibiotics in this lig ...
DOI:: 10.1007/s10295-015-1702-x
: https://doi.org/10.1007/s10295-015-1702-x

86. Bioinformatics tools and databases for whole genome sequence analysis of Mycobacterium tuberculosis

Author:: Kiatichai Faksri; Jun Hao Tan; Angkana Chaiprasert; Yik-Ying Teo; Rick Twee-Hee Ong
Source:: Infection, genetics, and evolution 2016 v.45 pp. 359-368
ISSN:: 1567-1348
Subject:: Mycobacterium tuberculosis; antibiotic resistance; antibiotics; bacteria; bioinformatics; computer software; cost effectiveness; disease transmission; evolution; genetic databases; genetic variation; genomics; high-throughput nucleotide sequencing; molecular epidemiology; nucleotide sequences; patients; public health; surveys; tuberculosis
Abstract:: ... Tuberculosis (TB) is an infectious disease of global public health importance caused by Mycobacterium tuberculosis complex (MTC) in which M. tuberculosis (Mtb) is the major causative agent. Recent advancements in genomic technologies such as next generation sequencing have enabled high throughput cost-effective generation of whole genome sequence information from Mtb clinical isolates, providing n ...
DOI:: 10.1016/j.meegid.2016.09.013
: https://doi.org/10.1016/j.meegid.2016.09.013

87. Could transformation mechanisms of acetylase-harboring pMdT1 plasmid be evaluated through proteomic tools in Escherichia coli?

Author:: Pedro Magalhães; Luís Pinto; Alexandre Gonçalves; José Eduardo Araújo; Hugo M. Santos; José Luis Capelo; Yolanda Saénz; María de Toro; Carmen Torres; Christophe Chambon; Michel Hébraud; Patrícia Poeta; Gilberto Igrejas
Source:: Journal of proteomics 2016 v.145 pp. 103-111
ISSN:: 1874-3919
Subject:: Escherichia coli; aminoglycosides; antibiotic resistance; antibiotics; bacteria; bioinformatics; electrophoresis; evolution; gastrointestinal system; gene transfer; genes; horizontal gene transfer; humans; liquid chromatography; matrix-assisted laser desorption-ionization mass spectrometry; plasmids; protein synthesis; proteins; proteome; proteomics; resistance mechanisms; tandem mass spectrometry
Abstract:: ... Escherichia coli is a commensal microorganism of the gastrointestinal tract of animals and humans and it is an excellent model organism for the study of antibiotic resistance mechanisms. The resistance transmission and other characteristics of bacteria are based on different types of gene transfer occurring throughout the bacterial evolution. One of which is horizontal gene transfer that allows us ...
DOI:: 10.1016/j.jprot.2016.03.042
: https://doi.org/10.1016/j.jprot.2016.03.042

88. Diversity and variation in antimicrobial susceptibility patterns over time in Mycoplasma agalactiae isolates collected from sheep and goats in France

Author:: F. Poumarat; A.V. Gautier‐Bouchardon; D. Bergonier; E. Gay; F. Tardy
Source:: Journal of applied microbiology 2016 v.120 no.5 pp. 1208-1218
ISSN:: 1364-5072
Subject:: Mycoplasma agalactiae; Mycoplasma bovis; agalactia; antibiotic resistance; antibiotics; cattle; dairy industry; evolution; financial economics; fluoroquinolones; genetic background; genetic relationships; genetic variation; goats; macrolides; minimum inhibitory concentration; pathogens; sheep; France
Abstract:: ... AIMS: Mycoplasma agalactiae is responsible for Contagious Agalactia, a severe syndrome affecting small ruminants worldwide and resulting in significant economic losses in countries with an important dairy industry. The aim of this study was to examine the antimicrobial susceptibility patterns of M. agalactiae isolates in France, their evolution over the last 25 years and their relationships with t ...
DOI:: 10.1111/jam.13083
: https://doi.org/10.1111/jam.13083

89. Interpreting phenotypic antibiotic tolerance and persister cells as evolution via epigenetic inheritance

Author:: Troy Day
Source:: Molecular ecology 2016 v.25 no.8 pp. 1869-1882
ISSN:: 0962-1083
Subject:: RNA; antibiotic resistance; antibiotics; bacteria; epigenetics; evolution; gene expression; models; parents; phenotype; progeny
Abstract:: ... Epigenetic inheritance is the transmission of nongenetic material such as gene expression levels, RNA and other biomolecules from parents to offspring. There is a growing realization that such forms of inheritance can play an important role in evolution. Bacteria represent a prime example of epigenetic inheritance because a large array of cellular components is transmitted to offspring, in additio ...
DOI:: 10.1111/mec.13603
PubMed:: 26946044
PubMed Central:: PMC4846567
: https://doi.org/10.1111/mec.13603

90. Isolation, genome sequencing and functional analysis of two T7-like coliphages of avian pathogenic Escherichia coli

Author:: Mianmian Chen; Juntian Xu; Huochun Yao; Chengping Lu; Wei Zhang
Source:: Gene 2016 v.582 no.1 pp. 47-58
ISSN:: 0378-1119
Subject:: DNA; Enterobacteria phages; Erwinia; Escherichia coli; Kluyvera; Podoviridae; antibiotic resistance; antibiotics; bacteria; birds; coliphages; drug residues; electron microscopy; evolution; farmers; feces; financial economics; genes; genomics; high-throughput nucleotide sequencing; markets; poultry industry; proteins; sequence homology; China
Abstract:: ... Avian pathogenic Escherichia coli (APEC) causes colibacillosis, which results in significant economic losses to the poultry industry worldwide. Due to the drug residues and increased antibiotic resistance caused by antibiotic use, bacteriophages and other alternative therapeutic agents are expected to control APEC infection in poultry.Two APEC phages, named P483 and P694, were isolated from the fe ...
DOI:: 10.1016/j.gene.2016.01.049
: https://doi.org/10.1016/j.gene.2016.01.049

91. Metagenomic Analysis Revealing Antibiotic Resistance Genes (ARGs) and Their Genetic Compartments in the Tibetan Environment

Author:: Chen Baowei; Yuan Ke; Chen Xin; Yang Ying; Zhang Tong; Wang Yawei; Luan Tiangang; Zou Shichun; Li Xiangdong
Source:: Environmental Science & Technology 2016 v.50 no.13 pp. 6670-6679
ISSN:: 1520-5851
Subject:: animal wastes; antibiotic resistance; antibiotics; bacteria; bacterial communities; beta-lactams; chemical analysis; community structure; evolution; fluoroquinolones; genes; interspersed repetitive sequences; metagenomics; sediments; soil; China
Abstract:: ... Comprehensive profiles of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in a minimally impacted environment are essential to understanding the evolution and dissemination of modern antibiotic resistance. Chemical analyses of the samples collected from Tibet demonstrated that the region under investigation was almost devoid of anthropogenic antibiotics. The soils, animal was ...
DOI:: 10.1021/acs.est.6b00619
: https://doi.org/10.1021/acs.est.6b00619

92. Probing minority population of antibiotic-resistant bacteria

Author:: Tianxun Huang; Yan Zheng; Ya Yan; Lingling Yang; Yihui Yao; Jiaxin Zheng; Lina Wu; Xu Wang; Yuqing Chen; Jinchun Xing; Xiaomei Yan
Source:: Biosensors & bioelectronics 2016 v.80 pp. 323-330
ISSN:: 0956-5663
Subject:: Escherichia coli; antibiotic resistance; antibiotics; bacteria; beta-lactamase; biosensors; evolution; flow cytometry; fluorescence; fluorescent dyes; microbial culture; microbial load; monitoring; monoclonal antibodies; nucleic acids; pathogens; public health; quantitative analysis; urine
Abstract:: ... The evolution and spread of antibiotic-resistant pathogens has become a major threat to public health. Advanced tools are urgently needed to quickly diagnose antibiotic-resistant infections to initiate appropriate treatment. Here we report the development of a highly sensitive flow cytometric method to probe minority population of antibiotic-resistant bacteria via single cell detection. Monoclonal ...
DOI:: 10.1016/j.bios.2016.01.054
: https://doi.org/10.1016/j.bios.2016.01.054

93. Pteridophytes: evolutionary boon as medicinal plants

Author:: Hit Kishore Goswami; Kakali Sen; Radhanath Mukhopadhyay
Source:: Plant genetic resources 2016 v.14 no.4 pp. 328-355
ISSN:: 1479-263X
Subject:: Athyrium niponicum; Azolla; Bryophyta; Ceratopteris; Cyrtomium; DNA; Davallia; Dicranopteris; Dryopteris; Equisetum hyemale; Gram-positive bacteria; Lycopodium; Marsilea; Microsorum; Mycobacterium phlei; Oriental traditional medicine; Paleozoic era; Polypodium; Polystichum; Pseudomonas aeruginosa; Pyrrosia; Salmonella Typhi; Salvinia; Staphylococcus aureus; Vibrio cholerae; active ingredients; alkaloids; amino acids; antibacterial properties; antibiotics; antioxidant activity; antioxidants; antiretroviral agents; biodiversity; biofertilizers; bioremediation; evolution; fatty acids; ferns and fern allies; flavonoids; flora; forest reserves; forests; freshwater; fronds; fungi; gene regulatory networks; genes; genomics; herbal medicines; human health; lakes; lichens; mammals; medicinal plants; neoplasms; oils; pharmaceutical industry; plant extracts; polyphenols; polysaccharides; reptiles; rhizomes; screening; secondary metabolites; steroids; surface water; tea; triterpenoids; vascular plants; weeds
Abstract:: ... Selective use of crude plant extracts has been the oldest ritual in ancient Indian Medicinal System ‘Ayurveda’, as well as in Traditional Chinese Medicine system for thousands of years. This has been well documented that herbal medicines of Chinese, Indian, Korean and Native American people had included bryophytes, lichens, lycophytes and ferns. Since antiquity, most of the ferns and fern allies h ...
DOI:: 10.1017/S1479262116000290
: https://doi.org/10.1017/S1479262116000290

94. Water Disinfection Byproducts Induce Antibiotic Resistance-Role of Environmental Pollutants in Resistance Phenomena

Author:: Li Dan; Zeng Siyu; He Miao; Gu April Z.
Source:: Environmental Science & Technology 2016 v.50 no.6 pp. 3193-3201
ISSN:: 1520-5851
Subject:: Escherichia coli; antibiotic resistance; antibiotics; byproducts; disinfection; drugs; evolution; genes; iodoacetic acid; minimum inhibitory concentration; mutation; pollutants; public health
Abstract:: ... The spread of antibiotic resistance represents a global threat to public health, and has been traditionally attributed to extensive antibiotic uses in clinical and agricultural applications. As a result, researchers have mostly focused on clinically relevant high-level resistance enriched by antibiotics above the minimal inhibitory concentrations (MICs). Here, we report that two common water disin ...
DOI:: 10.1021/acs.est.5b05113
PubMed:: 26928861
PubMed Central:: PMC6321747
: https://doi.org/10.1021/acs.est.5b05113

95. A gene cluster for the biosynthesis of moenomycin family antibiotics in the genome of teicoplanin producer Actinoplanes teichomyceticus

Author:: Liliya Horbal; Bohdan Ostash; Andriy Luzhetskyy; Suzanne Walker; Jorn Kalinowski; Victor Fedorenko
Source:: Applied microbiology and biotechnology 2016 v.100 no.17 pp. 7629-7638
ISSN:: 0175-7598
Subject:: Actinoplanes teichomyceticus; Streptomyces clavuligerus; Streptomyces ghanaensis; animal nutrition; antibiotics; biochemical pathways; biosynthesis; engineering; evolution; mechanism of action; microorganisms; multigene family; structural genes; structure-activity relationships
Abstract:: ... Moenomycins are phosphoglycolipid antibiotics notable for their extreme potency, unique mode of action, and proven record of use in animal nutrition without selection for resistant microflora. There is a keen interest in manipulation of structures of moenomycins in order to better understand their structure-activity relationships and to generate improved analogs. Only two almost identical moenomyc ...
DOI:: 10.1007/s00253-016-7685-3
: https://doi.org/10.1007/s00253-016-7685-3

96. The mechanisms whereby the green alga Chlorella ohadii, isolated from desert soil crust, exhibits unparalleled photodamage resistance

Author:: Haim Treves; Hagai Raanan; Isaac Kedem; Omer Murik; Nir Keren; Hagit Zer; Simon M. Berkowicz; Mario Giordano; Alessandra Norici; Yoram Shotland; Itzhak Ohad; Aaron Kaplan
Source:: new phytologist 2016 v.210 no.4 pp. 1229-1243
ISSN:: 0028-646X
Subject:: Chlorella; D1 protein; antibiotics; carbohydrate content; carbon cycle; carotenes; crops; desert soils; energy; evolution; genes; irradiation; lighting; lipids; oxygen production; photoinhibition; photosystem II; reducing agents; singlet oxygen; soil crusts; solar radiation; spectroscopy
Abstract:: ... Excess illumination damages the photosynthetic apparatus with severe implications with regard to plant productivity. Unlike model organisms, the growth of Chlorella ohadii, isolated from desert soil crust, remains unchanged and photosynthetic O₂ evolution increases, even when exposed to irradiation twice that of maximal sunlight. Spectroscopic, biochemical and molecular approaches were applied to ...
DOI:: 10.1111/nph.13870
: https://doi.org/10.1111/nph.13870

97. Staphylococcus aureus Sequences from Osteomyelitic Specimens of a Pathological Bone Collection from Pre-Antibiotic Times

Author:: Anna Lena Flux; Janine Mazanec; Birgit Strommenger; Susanne Hummel
Source:: Diversity 2017 v.9 no.4 pp. -
ISSN:: 1424-2818
Subject:: DNA; antibiotics; evolution; genes; methicillin-resistant Staphylococcus aureus; microorganisms; necropsy; nucleotide sequences; osteomyelitis; pathogens; polymerase chain reaction; public health
Abstract:: ... Staphylococcus aureus is a major pathogen causing osteomyelitis, amongst other diseases, and its methicillin-resistant form (MRSA) in particular poses a huge threat to public health. To increase our knowledge of the origin and evolution of S. aureus, genetic studies of historical microorganisms may be beneficial. Thus, the aim of this study was to investigate whether osteomyelitic skeletal materia ...
DOI:: 10.3390/d9040043
: https://doi.org/10.3390/d9040043

98. Comparative genome analysis of IncHI2 VIM-1 carbapenemase-encoding plasmids of Escherichia coli and Salmonella enterica isolated from a livestock farm in Germany

Author:: Linda Falgenhauer; Hiren Ghosh; Beatriz Guerra; Yancheng Yao; Moritz Fritzenwanker; Jennie Fischer; Reiner Helmuth; Can Imirzalioglu; Trinad Chakraborty
Source:: Veterinary microbiology 2017 v.200 pp. 114-117
ISSN:: 0378-1135
Subject:: Escherichia coli; Salmonella enterica; antibiotics; beta-lactamase; evolution; genes; heavy metals; humans; livestock; livestock and meat industry; plasmids; sequence analysis; Germany
Abstract:: ... Carbapenem-resistant Enterobacteriaceae are not any more isolated only from human settings, but also from livestock. We reported for the first time the presence of VIM-1 carbapenemases in a livestock farm in Germany. The VIM-1 resistance gene found in these farms was located on IncHI2 plasmids. In order to be able to analyse these plasmids in more detail, two different plasmids from a single farm ...
DOI:: 10.1016/j.vetmic.2015.09.001
: https://doi.org/10.1016/j.vetmic.2015.09.001

99. Plasmid and clonal interference during post horizontal gene transfer evolution

Author:: S. Bedhomme; D. Perez Pantoja; I. G. Bravo
Source:: Molecular ecology 2017 v.26 no.7 pp. 1832-1847
ISSN:: 0962-1083
Subject:: antibiotic resistance; antibiotics; clones; evolution; gene expression; genes; genetic resistance; high-throughput nucleotide sequencing; horizontal gene transfer; parasites; plasmids; public health; toxins
Abstract:: ... Plasmids are nucleic acid molecules that can drive their own replication in a living cell. They can be transmitted horizontally and can thrive in the host cell to high‐copy numbers. Plasmid replication and gene expression consume cellular resources and cells carrying plasmids incur fitness costs. But many plasmids carry genes that can be beneficial under certain conditions, allowing the cell to en ...
DOI:: 10.1111/mec.14056
PubMed:: 28206693
PubMed Central:: PMC5392415
: https://doi.org/10.1111/mec.14056

100. Regulation of conjugative transfer of plasmids and integrative conjugative elements

Author:: Luis Alfredo Bañuelos-Vazquez; Gonzalo Torres Tejerizo; Susana Brom
Source:: Plasmid 2017 v.91 pp. 82-89
ISSN:: 0147-619X
Subject:: antibiotics; chromosomes; evolution; genes; horizontal gene transfer; metal tolerance; pathogenesis; plasmids; quorum sensing; regulatory sequences; symbiosis
Abstract:: ... Horizontal gene transfer has been recognized as one of the principal contributors to bacterial evolution and diversification. One of the mechanisms involved in this process is conjugative transfer of plasmids and Integrative Conjugative Elements (ICEs). Plasmids and ICEs often encode traits beneficial for bacterial survival in specific environments, or for the establishment of symbiosis or pathoge ...
DOI:: 10.1016/j.plasmid.2017.04.002
: https://doi.org/10.1016/j.plasmid.2017.04.002

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1. Systematics and bionomics of the apoid obligate necrophages: the Trigona hypogea group (Hymenoptera: Apidae; Meliponinae)

2. Environmentally friendly approaches to genetic engineering

3. The Exoskeleton of Bacterial Cells (the Sacculus): Still a Highly Attractive Target for Antibacterial Agents That Will Last For a Long Time

4. Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins

5. Understanding the rise of the superbug: investigation of the evolution and genomic variation of Staphylococcus aureus

6. Microbial intervention for better fish health in aquaculture: the Indian scenario

7. Antimicrobial peptides: natural templates for synthetic membrane-active compounds

8. Comparative analysis of essential genes and nonessential genes in Escherichia coli K12

9. Evolution of pathogens in a man-made world

10. Pathogenomics of the staphylococci: insights into niche adaptation and the emergence of new virulent strains

11. The rate of environmental change drives adaptation to an antibiotic sink

12. Drug efflux pump deficiency and drug target resistance masking in growing bacteria

13. Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy

14. Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock

15. The role of antibiotics and antibiotic resistance in nature

16. Adaptive landscapes and protein evolution

17. Antimicrobial natural products: an update on future antibiotic drug candidates

18. Commensal bacteria play a role in mating preference of Drosophila melanogaster

19. Disk prediffusion is a reliable method for testing colistin susceptibility in porcine E. coli strains

20. Helix insertion into bilayers and the evolution of membrane proteins

21. Origin and evolution of peptide-modifying dioxygenases and identification of the wybutosine hydroxylase/hydroperoxidase

22. A public choice framework for controlling transmissible and evolving diseases

23. The structure of ribosome-lankacidin complex reveals ribosomal sites for synergistic antibiotics

24. Characterization of L1 retrotransposition with high-throughput dual-luciferase assays

25. Class 1 integrons in environmental and clinical isolates of Pseudomonas aeruginosa

26. Competence in Streptococcus pneumoniae Is Regulated by the Rate of Ribosomal Decoding Errors

27. Synthetic inter-species cooperation of host and virus for targeted genetic evolution

28. Trade-off between growth and immune function: a meta-analysis of selection experiments

29. Vibrio cholerae O1 lineages driving cholera outbreaks during seventh cholera pandemic in Ghana

30. Whole-Genome Sequencing and Phenotypic Analysis of Bacillus subtilis Mutants following Evolution under Conditions of Relaxed Selection for Sporulation

31. Changing epidemiology of pediatric Streptococcus pneumoniae isolates before vaccine introduction in Casablanca (Morocco)

32. E622, a Miniature, Virulence-Associated Mobile Element

33. The Evolution of Cefotaximase Activity in the TEM β-Lactamase

34. On the rapidity of antibiotic resistance evolution facilitated by a concentration gradient

35. Plants as sources of new antimicrobials and resistance-modifying agents

36. Resistance Phenotypes Mediated by Aminoacyl-Phosphatidylglycerol Synthases

37. The Role of Clonal Interference in the Evolutionary Dynamics of Plasmid-Host Adaptation

38. Selection of resistance at lethal and non-lethal antibiotic concentrations

39. Bacterial resistance to cationic antimicrobial peptides

40. Co-Evolutionary Dynamics of the Bacteria Vibrio sp. CV1 and Phages V1G, V1P1, and V1P2: Implications for Phage Therapy

41. Development of a poly(ether urethane) system for the controlled release of two novel anti-biofilm agents based on gallium or zinc and its efficacy to prevent bacterial biofilm formation

42. Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3″)-Ii/AAC(6′)-IId from Serratia marcescens

43. Francisella noatunensis subsp. noatunensis replicates within Atlantic cod (Gadus morhua L.) leucocytes and inhibits respiratory burst activity

44. Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian β-Lactamases

45. Molecular prophage typing of avian pathogenic Escherichia coli

46. Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE

47. Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance

48. Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus

49. Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata

50. Antibiotic-Induced Replication Stress Triggers Bacterial Competence by Increasing Gene Dosage near the Origin

51. Epidemiology of asexuality induced by the endosymbiotic Wolbachia across phytophagous wasp species: host plant specialization matters

52. Evolution of Resistance to Quorum-Sensing Inhibitors

53. Evolution of extensively drug-resistant Mycobacterium tuberculosis from a susceptible ancestor in a single patient

54. Gene networks regulating secondary metabolism in actinomycetes: Pleiotropic regulators

55. An Indigenous Gut Bacterium, Enterococcus faecalis (Lactobacillales: Enterococcaceae), Increases Seed Consumption By Harpalus pensylvanicus (Coleoptera: Carabidae)

56. Insights on evolution of virulence and resistance from the whole-genome analysis of a predominant methicillin-resistant Staphylococcus aureus clone sequence type 239 in China

57. Molecular evolution of the bacterial pseudouridine‐5′‐phosphate glycosidase protein family

58. Morphological optimization for access to dual oxidants in biofilms

59. NP/MS since 1970: from the basement to the bench top

60. Natural solution to antibiotic resistance: bacteriophages ‘The Living Drugs’

61. Oxidative stress response in Pseudomonas putida

62. Sanitizing the fortress: protection of ant brood and nest material by worker antibiotics

63. Staphylococcus aureus Alters Growth Activity, Autolysis, and Antibiotic Tolerance in a Human Host-Adapted Pseudomonas aeruginosa Lineage

64. Widening the Spaces of Selection: Evolution along Sublethal Antimicrobial Gradients

65. The agriciultural antibiotic carbadox induces phage-mediated gene transfer in Salmonella

66. Activation of the σᴱ-Dependent Stress Pathway by Conjugative TraR May Anticipate Conjugational Stress

67. Antimicrobial interactions: mechanisms and implications for drug discovery and resistance evolution

68. Cold-adapted bacteria from a coastal area of the Ross Sea (Terra Nova Bay, Antarctica): linking microbial ecology to biotechnology

69. Collateral sensitivity of antibiotic-resistant microbes

70. Comparative morpho-physiology of the metapleural glands of two Atta leaf-cutting ant queens nesting in clayish and organic soils