Subject: antibiotics and evolution - PubAg Search Results

1. Staphylococcus aureus Sequences from Osteomyelitic Specimens of a Pathological Bone Collection from Pre-Antibiotic Times

Author:: Anna Lena Flux; Janine Mazanec; Birgit Strommenger; Susanne Hummel
Source:: Diversity 2017 v.9 no.4 pp. -
ISSN:: 1424-2818
Subject:: DNA; antibiotics; evolution; genes; methicillin-resistant Staphylococcus aureus; microorganisms; necropsy; nucleotide sequences; osteomyelitis; pathogens; polymerase chain reaction; public health
Abstract:: ... Staphylococcus aureus is a major pathogen causing osteomyelitis, amongst other diseases, and its methicillin-resistant form (MRSA) in particular poses a huge threat to public health. To increase our knowledge of the origin and evolution of S. aureus, genetic studies of historical microorganisms may be beneficial. Thus, the aim of this study was to investigate whether osteomyelitic skeletal materia ...
DOI:: 10.3390/d9040043
: https://doi.org/10.3390/d9040043

2. ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance: Structural and Functional Diversification across the Tree of Life

Author:: Victoriia Murina; Marje Kasari; Hiraku Takada; Mariliis Hinnu; Chayan Kumar Saha; James W. Grimshaw; Takahiro Seki; Michael Reith; Marta Putrinš; Tanel Tenson; Henrik Strahl; Vasili Hauryliuk; Gemma Catherine Atkinson
Source:: Journal of molecular biology 2019 v.431 no.18 pp. 3568-3590
ISSN:: 0022-2836
Subject:: Bacillus subtilis; Escherichia coli; Saccharomyces cerevisiae; adenosinetriphosphatase; ancestry; animal pathogens; antibiotic resistance; antibiotics; evolution; genome; guanosinetriphosphatase; mutants; protein synthesis; ribosomes; transferases
Abstract:: ... Within the larger ABC superfamily of ATPases, ABCF family members eEF3 in Saccharomyces cerevisiae and EttA in Escherichia coli have been found to function as ribosomal translation factors. Several other ABCFs including biochemically characterized VgaA, LsaA and MsrE confer resistance to antibiotics that target the peptidyl transferase center and exit tunnel of the ribosome. However, the diversity ...
DOI:: 10.1016/j.jmb.2018.12.013
PubMed:: 30597160
PubMed Central:: PMC6723617
: https://doi.org/10.1016/j.jmb.2018.12.013

3. Activation of the σᴱ-Dependent Stress Pathway by Conjugative TraR May Anticipate Conjugational Stress

Author:: Elicia D. Grace; Saumya Gopalkrishnan; Mary E. Girard; Matthew D. Blankschien; Wilma Ross; Richard L. Gourse; Christophe Herman
Source:: Journal of bacteriology 2015 v.197 no.5 pp. 924-931
ISSN:: 0021-9193
Subject:: DNA-directed RNA polymerase; Escherichia coli; antibiotic resistance; antibiotics; bacteria; biosynthesis; evolution; fimbriae; horizontal gene transfer; pathogens; plasmids; protein folding; proteinases; signal transduction; stress response; virulence
Abstract:: ... Horizontal gene transfer by conjugation plays a major role in bacterial evolution, allowing the acquisition of new traits, such as virulence and resistance to antibacterial agents. With the increased antibiotic resistance in bacterial pathogens, a better understanding of how bacteria modulate conjugation under changing environments and the genetic factors involved is needed. Despite the evolutiona ...
DOI:: 10.1128/JB.02279-14
PubMed:: 25535270
PubMed Central:: PMC4325106
: https://doi.org/10.1128/JB.02279-14

4. Adaptive landscapes and protein evolution

Author:: Carneiro, Maurício; Hartl, Daniel L.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.suppl_1 pp. 1747-1751
ISSN:: 0027-8424
Subject:: antibiotics; evolution; insecticide resistance; mutants; proteins; vaccines
Abstract:: ... The principles governing protein evolution under strong selection are important because of the recent history of evolved resistance to insecticides, antibiotics, and vaccines. One experimental approach focuses on studies of mutant proteins and all combinations of mutant sites that could possibly be intermediates in the evolutionary pathway to resistance. In organisms carrying each of the engineere ...
DOI:: 10.1073/pnas.0906192106
PubMed:: 19805125
PubMed Central:: PMC2868285
: https://doi.org/10.1073/pnas.0906192106

5. Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance

Author:: Seungsoo Kim; Tami D. Lieberman; Roy Kishony
Source:: Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.40 pp. 14494-14499
ISSN:: 0027-8424
Subject:: antibiotic resistance; antibiotics; combination drug therapy; drugs; evolution; multiple drug resistance; mutation; sequence analysis; toxicity
Abstract:: ... Alternating antibiotic therapy, in which pairs of drugs are cycled during treatment, has been suggested as a means to inhibit the evolution of de novo resistance while avoiding the toxicity associated with more traditional combination therapy. However, it remains unclear under which conditions and by what means such alternating treatments impede the evolution of resistance. Here, we tracked multis ...
DOI:: 10.1073/pnas.1409800111
PubMed:: 25246554
PubMed Central:: PMC4210010
: https://doi.org/10.1073/pnas.1409800111

6. Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus

Author:: Kayeon Lee; Jin-Hyung Lee; Soon-Il Kim; Moo Hwan Cho; Jintae Lee
Source:: Applied microbiology and biotechnology 2014 v.98 no.22 pp. 9447-9457
ISSN:: 0175-7598
Subject:: Caenorhabditis elegans; Cananga; Staphylococcus aureus; antibiotics; bacteria; biofilm; black pepper; cell viability; essential oils; evolution; gene expression regulation; hemolysis; humans; multiple drug resistance; oils; pathogens; regulator genes; screening; transcription (genetics); virulence
Abstract:: ... The long-term usage of antibiotics has resulted in the evolution of multidrug-resistant bacteria. Unlike antibiotics, anti-virulence approaches target bacterial virulence without affecting cell viability, which may be less prone to develop drug resistance. Staphylococcus aureus is a major human pathogen that produces diverse virulence factors, such as α-toxin, which is hemolytic. Also, biofilm for ...
DOI:: 10.1007/s00253-014-5903-4
PubMed:: 25027570
: https://doi.org/10.1007/s00253-014-5903-4

7. Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata

Author:: Babita Paudel; Hari Datta Bhattarai; Hong Kum Lee; Hyuncheol Oh; Hyun Woung Shin; Joung Han Yim
Source:: Zeitschrift für Naturforschung 2014 v.65 no.1-2 pp. 34-38
ISSN:: 1865-7125
Subject:: Bacillus subtilis; Ramalina; Staphylococcus aureus; antibacterial properties; antibiotics; bacteria; chromatography; disk diffusion antimicrobial test; drugs; evolution; lichens; methanol; minimum inhibitory concentration; usnic acid; Antarctic region
Abstract:: ... The development of new antibacterial compounds is an urgent issue to meet the evolution of resistivity of pathogenic bacteria against the available drugs. The objective of this study was to investigate the antibacterial compounds from the Antarctic lichen species Ramalina terebrata. A total of fi ve compounds, usnic acid, usimine A, usimine B, usimine C, and ramalin, were isolated by bioactivity g ...
DOI:: 10.1515/znc-2010-1-206
: https://doi.org/10.1515/znc-2010-1-206

8. Antibiotic Adjuvants: Rescuing Antibiotics from Resistance

Author:: Gerard D. Wright
Source:: Trends in microbiology 2016 v.24 no.11 pp. 862-871
ISSN:: 0966-842X
Subject:: adjuvants; antibacterial properties; antibiotic resistance; antibiotics; drugs; evolution; mechanism of action; pathogens
Abstract:: ... Rooted in the mechanism of action of antibiotics and subject to bacterial evolution, antibiotic resistance is difficult and perhaps impossible to overcome. Nevertheless, strategies can be used to minimize the emergence and impact of resistance. Antibiotic adjuvants offer one such approach. These are compounds that have little or no antibiotic activity themselves but act to block resistance or othe ...
DOI:: 10.1016/j.tim.2016.06.009
: https://doi.org/10.1016/j.tim.2016.06.009

9. Antibiotic resistome in the livestock and aquaculture industries: Status and solutions

Author:: Yi Zhao; Qiu E. Yang; Xue Zhou; Feng-Hua Wang; Johanna Muurinen; Marko P. Virta; Kristian Koefoed Brandt; Yong-Guan Zhu
Source:: Critical reviews in environmental science and technology 2021 v.51 no.19 pp. 2159-2196
ISSN:: 1547-6537
Subject:: One Health initiative; animal production; antibiotic resistance; antibiotic resistance genes; antibiotics; environmental health; environmental science; evolution; human health; humans; livestock; livestock and meat industry; technology
Abstract:: ... Since the introduction of antibiotics into clinical practices in the 1940s, antibiotics have become an integral part of animal production to meet the increasing human demand for animal-derived foods. As a result, industrial-scale animal production has emerged as a hotspot for the evolution and dissemination of antibiotic resistance genes (ARGs), thereby potentially contributing to a looming public ...
DOI:: 10.1080/10643389.2020.1777815
: https://doi.org/10.1080/10643389.2020.1777815

10. Antibiotic-Induced Replication Stress Triggers Bacterial Competence by Increasing Gene Dosage near the Origin

Author:: Jelle Slager; Morten Kjos; Laetitia Attaiech; Jan-Willem Veening
Source:: Cell 2014 v.157 pp. 395-406
ISSN:: 0092-8674
Subject:: DNA; DNA replication; Streptococcus pneumoniae; antibiotic resistance; antibiotics; bacteria; children; evolution; gene dosage; gene expression; genes; human health; replication origin; transcriptome
Abstract:: ... Streptococcus pneumoniae (pneumococcus) kills nearly 1 million children annually, and the emergence of antibiotic-resistant strains poses a serious threat to human health. Because pneumococci can take up DNA from their environment by a process called competence, genes associated with antibiotic resistance can rapidly spread. Remarkably, competence is activated in response to several antibiotics. H ...
DOI:: 10.1016/j.cell.2014.01.068
: https://doi.org/10.1016/j.cell.2014.01.068

11. Antibiotics and evolution: food for thought

Author:: C. R. Strachan; J. Davies
Source:: Journal of industrial microbiology & biotechnology 2016 v.43 no.2-3 pp. 149-153
ISSN:: 1367-5435
Subject:: antibiotics; evolution; molecular weight; polymerization; polypeptides; receptors; secondary metabolites
Abstract:: ... The role of secondary metabolites in effecting and modulating reactions during early biochemical evolution has been largely unappreciated. It is possible that low molecular weight effectors were gradually replaced by polypeptides as polymerizing reactions became more complex, but retained some ability to interact with original receptor sites. Indeed, by reviewing the era of antibiotics in this lig ...
DOI:: 10.1007/s10295-015-1702-x
: https://doi.org/10.1007/s10295-015-1702-x

12. Antimicrobial interactions: mechanisms and implications for drug discovery and resistance evolution

Author:: Tobias Bollenbach
Source:: Current opinion in microbiology 2015 v.27 pp. 1-9
ISSN:: 1369-5274
Subject:: antibiotics; cell physiology; combination drug therapy; drug interactions; drugs; evolution; prediction
Abstract:: ... Combining antibiotics is a promising strategy for increasing treatment efficacy and for controlling resistance evolution. When drugs are combined, their effects on cells may be amplified or weakened, that is the drugs may show synergistic or antagonistic interactions. Recent work revealed the underlying mechanisms of such drug interactions by elucidating the drugs’ joint effects on cell physiology ...
DOI:: 10.1016/j.mib.2015.05.008
: https://doi.org/10.1016/j.mib.2015.05.008

13. Antimicrobial natural products: an update on future antibiotic drug candidates

Author:: Muhammad Saleem; Mamona Nazir; Muhammad Shaiq Ali; Hidayat Hussain; Yong Sup Lee; Naheed Riaz; Abdul Jabbar
Source:: Natural product reports 2010 v.27 no.2 pp. 238-254
ISSN:: 1460-4752
Subject:: antibiotics; antimicrobial properties; evolution; markets; metabolites; pathogens; toxicity
Abstract:: ... Over the last decade, it has become clear that antimicrobial drugs are losing their effectiveness due to the evolution of pathogen resistance. There is therefore a continuing need to search for new antibiotics, especially as new drugs only rarely reach the market. Natural products are both fundamental sources of new chemical diversity and integral components of today's pharmaceutical compendium, a ...
DOI:: 10.1039/b916096e
: https://doi.org/10.1039/b916096e

14. Antimicrobial peptides: natural templates for synthetic membrane-active compounds

Author:: Giuliani, A.; Pirri, G.; Bozzi, A.; Di Giulio, A.; Aschi, M.; Rinaldi, A. C.
Source:: Cellular and molecular life sciences 2008 v.65 no.16 pp. 2450-2460
ISSN:: 1420-682X
Subject:: antibiotics; antimicrobial peptides; biomimetics; cell membranes; evolution; innate immunity; mechanism of action; synthetic peptides
Abstract:: ... The innate immunity of multicellular organisms relies in large part on the action of antimicrobial peptides (AMPs) to resist microbial invasion. Crafted by evolution into an extremely diversified array of sequences and folds, AMPs do share a common amphiphilic 3-D arrangement. This feature is directly linked with a common mechanism of action that predominantly (although not exclusively) develops u ...
DOI:: 10.1007/s00018-008-8188-x
PubMed:: 18661101
: https://doi.org/10.1007/s00018-008-8188-x

15. Application of biosolids drives the diversity of antibiotic resistance genes in soil and lettuce at harvest

Author:: Lu Yang; Wuxing Liu; Dong Zhu; Jinyu Hou; Tingting Ma; Longhua Wu; Yongguan Zhu; Peter Christie
Source:: Soil biology & biochemistry 2018 v.122 pp. 131-140
ISSN:: 0038-0717
Subject:: antibiotic resistance genes; antibiotics; biosolids; endophytes; evolution; leaves; lettuce; quantitative polymerase chain reaction; ready-to-eat foods; roots; shoots; soil
Abstract:: ... High-throughput quantitative polymerase chain reaction (PCR) of antibiotic resistance genes (ARGs) was used to profile the composition and diversity of ARGs in biosolid-amended soil and in lettuce roots and shoots. Biosolid application significantly increased the ARGs in soil and influenced the soil antibiotics resistome mainly through exogenous introduction. Four dominant ARGs occurred in sterili ...
DOI:: 10.1016/j.soilbio.2018.04.017
: https://doi.org/10.1016/j.soilbio.2018.04.017

16. Bacterial resistance to cationic antimicrobial peptides

Author:: José Luis Anaya-López; Joel Edmundo López-Meza; Alejandra Ochoa-Zarzosa
Source:: Critical reviews in microbiology 2013 v.39 no.2 pp. 180-195
ISSN:: 1549-7828
Subject:: antibiotic resistance; antibiotics; antimicrobial peptides; bacteria; electrostatic interactions; evolution; mechanism of action; resistance mechanisms; therapeutics; virulent strains
Abstract:: ... Naturally occurring cationic antimicrobial peptides (CAMPs) have been considered as promising candidates to treat infections caused by pathogenic bacteria to animals and humans. This assumption is based on their mechanism of action, which is mainly performed through electrostatic membrane interactions. Unfortunately, the rise in the reports that describe bacterial resistance to CAMPs has redefined ...
DOI:: 10.3109/1040841X.2012.699025
: https://doi.org/10.3109/1040841X.2012.699025

17. Biodegradable Antimicrobial Food Packaging: Trends and Perspectives

Author:: Ludmila Motelica; Denisa Ficai; Anton Ficai; Ovidiu Cristian Oprea; Durmuş Alpaslan Kaya; Ecaterina Andronescu
Source:: Foods 2020 v.9 no.10 pp. -
ISSN:: 2304-8158
Subject:: active ingredients; agricultural resources; animals; antibiotics; antimicrobial packaging; antioxidant activity; bacteriocins; biodegradability; biopolymers; cellulose; chitosan; essential oils; evolution; extracts; food packaging; foods; industry; lipids; nanoparticles; packaging materials; plastics; pollution; polylactic acid; polyvinyl alcohol; public opinion; research; shelf life; solutions; starch; wastes
Abstract:: ... This review presents a perspective on the research trends and solutions from recent years in the domain of antimicrobial packaging materials. The antibacterial, antifungal, and antioxidant activities can be induced by the main polymer used for packaging or by addition of various components from natural agents (bacteriocins, essential oils, natural extracts, etc.) to synthetic agents, both organic ...
DOI:: 10.3390/foods9101438
: https://doi.org/10.3390/foods9101438

18. Bioinformatics tools and databases for whole genome sequence analysis of Mycobacterium tuberculosis

Author:: Kiatichai Faksri; Jun Hao Tan; Angkana Chaiprasert; Yik-Ying Teo; Rick Twee-Hee Ong
Source:: Infection, genetics, and evolution 2016 v.45 pp. 359-368
ISSN:: 1567-1348
Subject:: Mycobacterium tuberculosis; antibiotic resistance; antibiotics; bacteria; bioinformatics; computer software; cost effectiveness; disease transmission; evolution; genetic databases; genetic variation; genomics; high-throughput nucleotide sequencing; molecular epidemiology; nucleotide sequences; patients; public health; surveys; tuberculosis
Abstract:: ... Tuberculosis (TB) is an infectious disease of global public health importance caused by Mycobacterium tuberculosis complex (MTC) in which M. tuberculosis (Mtb) is the major causative agent. Recent advancements in genomic technologies such as next generation sequencing have enabled high throughput cost-effective generation of whole genome sequence information from Mtb clinical isolates, providing n ...
DOI:: 10.1016/j.meegid.2016.09.013
: https://doi.org/10.1016/j.meegid.2016.09.013

19. Candida albicans, a reservoir of Listeria monocytogenes?

Author:: Susana Castro-Seriche; Alonso Jerez-Morales; Carlos T. Smith; Kimberly Sánchez-Alonzo; Apolinaria García-Cancino
Source:: Infection, genetics, and evolution 2021 v.90 pp. 104779
ISSN:: 1567-1348
Subject:: Candida albicans; DNA; Listeria monocytogenes; agar; antibiotics; chloramphenicol; coculture; evolution; fluorescence; genes; humans; infection; light microscopy; pathogenicity; pathogens; risk; temperature; transmission electron microscopy; viability; yeasts
Abstract:: ... Listeria monocytogenes is a pathogen causing serious or mortal infections in human risk populations. Its infectivity is in part due to its ability to infect diverse eukaryotic cells. Since several bacteria can enter into yeast cells, including Candida albicans, the aims of this work were to evaluate if L. monocytogenes was able to harbor, retaining its viability, within C. albicans cells and to ev ...
DOI:: 10.1016/j.meegid.2021.104779
: https://doi.org/10.1016/j.meegid.2021.104779

20. Changes in the Oxidative Stress Status of Dogs Affected by Acute Enteropathies

Author:: Alessia Candellone; Flavia Girolami; Paola Badino; Watanya Jarriyawattanachaikul; Rosangela Odore
Source:: Veterinary sciences 2022 v.9 no.6 pp. -
ISSN:: 2306-7381
Subject:: antibiotics; antioxidant activity; blood serum; diarrhea; dogs; evolution; oxidative stress; patients; reactive oxygen species; therapeutics
Abstract:: ... Canine acute enteropathies (AE) are common morbidities primarily managed with supportive therapy. However, in some cases, unnecessary courses of antibiotics are empirically prescribed. Recent studies in humans have hypothesized the use of antioxidants as a possible alternative and/or support to antimicrobial drugs in uncomplicated cases. Considering the global need to reduce the antibiotic use, th ...
DOI:: 10.3390/vetsci9060276
: https://doi.org/10.3390/vetsci9060276

21. Changing epidemiology of pediatric Streptococcus pneumoniae isolates before vaccine introduction in Casablanca (Morocco)

Author:: Naima Elmdaghri; Mohamed Benbachir; Houria Belabbes; Bahija Zaki; Hanane Benzaid
Source:: Vaccine 2012 v.30S6 no. pp. G46
ISSN:: 0264-410X
Subject:: Streptococcus pneumoniae; antibiotic resistance; antibiotics; children; epidemiology; evolution; monitoring; serotypes; vaccines; Morocco
Abstract:: ... The objective of this study was to describe the evolution over time of serotypes and antimicrobial resistance of Streptococcus pneumoniae isolates responsible for invasive pneumococcal disease (IPD) in children ≤5years in Casablanca (Morocco), before vaccine introduction. Isolates recovered from cases of IPD in children ≤5years during two study periods (1994–2001 and 2006–2010) were compared in te ...
DOI:: 10.1016/j.vaccine.2012.10.044
: https://doi.org/10.1016/j.vaccine.2012.10.044

22. Characterization and genome analysis of the temperate bacteriophage φSAJS1 from Streptomyces avermitilis

Author:: Nana Lu; Choljin Kim; Zhi Chen; Ying Wen; Qing Wei; Yi Qiu; Shiwei Wang; Yuan Song
Source:: Virus research 2019 v.265 pp. 34-42
ISSN:: 0168-1702
Subject:: DNA; DNA packaging; Siphoviridae; Streptomyces avermitilis; Streptomyces griseus; antibiotics; bacteria; bacteriophages; calcium; evolution; fermentation; genome; growth curves; host range; open reading frames; pH; proteins; sequence analysis; temperature; transmission electron microscopy
Abstract:: ... Streptomyces is an important antibiotic-producing bacterium; however, antibiotic production is often negatively affected by bacteriophage contamination. In the present study, the temperate phage φSAJS1 was isolated and characterized from an unsuccessful Streptomyces avermitilis fermentation culture. The complete genome of phage φSAJS1 was sequenced. Phage φSAJS1 belongs to the Siphoviridae family ...
DOI:: 10.1016/j.virusres.2019.03.006
: https://doi.org/10.1016/j.virusres.2019.03.006

23. Characterization of L1 retrotransposition with high-throughput dual-luciferase assays

Author:: Xie, Yi; Rosser, James M.; Thompson, Tina L.; Boeke, Jef D.; An, Wenfeng
Source:: Nucleic acids research 2011 v.39 no.3 pp. e16
ISSN:: 0305-1048
Subject:: antibiotics; cultured cells; evolution; fluorescent proteins; genome; humans; luciferase; mice; plasmids; screening; transfection
Abstract:: ... Recent studies employing genome-wide approaches have provided an unprecedented view of the scope of L1 activities on structural variations in the human genome, and further reinforced the role of L1s as one of the major driving forces behind human genome evolution. The rapid identification of novel L1 elements by these high-throughput approaches demands improved L1 functional assays. However, the e ...
DOI:: 10.1093/nar/gkq1076
PubMed:: 21071410
PubMed Central:: PMC3035435
: https://doi.org/10.1093/nar/gkq1076

24. Class 1 integrons in environmental and clinical isolates of Pseudomonas aeruginosa

Author:: L. Ruiz-Martínez; L. López-Jiménez; E. Fusté; T. Vinuesa; J.P. Martínez; M. Viñas
Source:: International journal of antimicrobial agents 2011 v.38 no.5 pp. 398-402
ISSN:: 0924-8579
Subject:: Pseudomonas aeruginosa; aminoglycosides; antibiotics; chromosomes; evolution; genes; pathogens; plasmids; polymerase chain reaction
Abstract:: ... The aims of this study were to ascertain the presence and spread of class 1 integrons amongst environmental and clinical isolates of Pseudomonas aeruginosa and to characterise their variable regions. A total of 76 isolates (56 clinical and 20 environmental) were studied. The presence of plasmids was explored, and polymerase chain reaction (PCR) was used for integron detection. All amplicons were s ...
DOI:: 10.1016/j.ijantimicag.2011.06.016
: https://doi.org/10.1016/j.ijantimicag.2011.06.016

25. Co-Evolutionary Dynamics of the Bacteria Vibrio sp. CV1 and Phages V1G, V1P1, and V1P2: Implications for Phage Therapy

Author:: Camilo Barbosa; Patrick Venail; Angela V. Holguin; Martha J. Vives
Source:: Microbial ecology 2013 v.66 no.4 pp. 897-905
ISSN:: 0095-3628
Subject:: Vibrio; antibiotics; bacteria; bacterial infections; bacteriophages; evolution; food industry; hatcheries; larvae; mortality; pathogenicity; shrimp; therapeutics
Abstract:: ... Bacterial infections are the second largest cause of mortality in shrimp hatcheries. Among them, bacteria from the genus Vibrio constitute a major threat. As the use of antibiotics may be ineffective and banned from the food sector, alternatives are required. Historically, phage therapy, which is the use of bacteriophages, is thought to be a promising option to fight against bacterial infections. ...
DOI:: 10.1007/s00248-013-0284-2
PubMed:: 24013213
: https://doi.org/10.1007/s00248-013-0284-2

26. Cold-adapted bacteria from a coastal area of the Ross Sea (Terra Nova Bay, Antarctica): linking microbial ecology to biotechnology

Author:: Angelina Lo Giudice; Renato Fani
Source:: Hydrobiologia 2015 v.761 no.1 pp. 417-441
ISSN:: 0018-8158
Subject:: sediments; bioactive properties; antibiotics; evolution; heavy metals; humans; biotechnology; biochemical pathways; environmental factors; polychlorinated biphenyls; seawater; secondary metabolites; bacterial communities; anthropogenic activities; coasts; temperature; bacteria; Antarctica; Antarctic region
Abstract:: ... This review covers available information concerning the bacterial communities inhabiting coastal areas of Terra Nova Bay (Antarctica). Research was mainly focused on seawater, sediment, and benthic filter feeders. Coping with adverse environmental conditions, Antarctic bacteria have evolved peculiar strategies to survive in this harsh environment. In addition to cellular modifications, antagonisti ...
DOI:: 10.1007/s10750-015-2497-5
: https://doi.org/10.1007/s10750-015-2497-5

27. Collateral sensitivity of antibiotic-resistant microbes

Author:: Csaba Pál; Balázs Papp; Viktória Lázár
Source:: Trends in microbiology 2015 v.23 no.7 pp. 401-407
ISSN:: 0966-842X
Subject:: antibiotic resistance; antibiotics; bacteria; drugs; evolution; multiple drug resistance; mutation; resistance mechanisms; sequence analysis
Abstract:: ... Understanding how evolution of microbial resistance towards a given antibiotic influences susceptibility to other drugs is a challenge of profound importance. By combining laboratory evolution, genome sequencing, and functional analyses, recent works have charted the map of evolutionary trade-offs between antibiotics and have explored the underlying molecular mechanisms. Strikingly, mutations that ...
DOI:: 10.1016/j.tim.2015.02.009
PubMed:: 25818802
PubMed Central:: PMC5958998
: https://doi.org/10.1016/j.tim.2015.02.009

28. Commensal bacteria play a role in mating preference of Drosophila melanogaster

Author:: Sharon, Gil; Segal, Daniel; Ringo, John M.; Hefetz, Abraham; Zilber-Rosenberg, Ilana; Rosenberg, Eugene
Source:: Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.46 pp. 20051-20056
ISSN:: 0027-8424
Subject:: Drosophila melanogaster; Lactobacillus plantarum; antibiotics; bacteria; evolution; mating behavior; microsymbionts; mixed culture; molasses; rearing; sex pheromones; starch
Abstract:: ... Development of mating preference is considered to be an early event in speciation. In this study, mating preference was achieved by dividing a population of Drosophila melanogaster and rearing one part on a molasses medium and the other on a starch medium. When the isolated populations were mixed, "molasses flies" preferred to mate with other molasses flies and "starch flies" preferred to mate wit ...
DOI:: 10.1073/pnas.1009906107
PubMed:: 21041648
PubMed Central:: PMC2993361
: https://doi.org/10.1073/pnas.1009906107

29. Comparative analysis of essential genes and nonessential genes in Escherichia coli K12

Author:: Gong, Xiaodong; Fan, Shaohua; Bilderbeck, Amy; Li, Mingkun; Pang, Hongxia; Tao, Shiheng
Source:: Molecular genetics and genomics 2008 v.279 no.1 pp. 87-94
ISSN:: 1617-4615
Subject:: Escherichia coli K12; amino acids; antibiotics; evolution; genes; mutagenesis; prediction; proteins
Abstract:: ... Genes can be classified as essential or nonessential based on their indispensability for a living organism. Previous researches have suggested that essential genes evolve more slowly than nonessential genes and the impact of gene dispensability on a gene's evolutionary rate is not as strong as expected. However, findings have not been consistent and evidence is controversial regarding the relation ...
DOI:: 10.1007/s00438-007-0298-x
PubMed:: 17943314
: https://doi.org/10.1007/s00438-007-0298-x

30. Comparative genome analysis of IncHI2 VIM-1 carbapenemase-encoding plasmids of Escherichia coli and Salmonella enterica isolated from a livestock farm in Germany

Author:: Linda Falgenhauer; Hiren Ghosh; Beatriz Guerra; Yancheng Yao; Moritz Fritzenwanker; Jennie Fischer; Reiner Helmuth; Can Imirzalioglu; Trinad Chakraborty
Source:: Veterinary microbiology 2017 v.200 pp. 114-117
ISSN:: 0378-1135
Subject:: Escherichia coli; Salmonella enterica; antibiotics; beta-lactamase; evolution; genes; heavy metals; humans; livestock; livestock and meat industry; plasmids; sequence analysis; Germany
Abstract:: ... Carbapenem-resistant Enterobacteriaceae are not any more isolated only from human settings, but also from livestock. We reported for the first time the presence of VIM-1 carbapenemases in a livestock farm in Germany. The VIM-1 resistance gene found in these farms was located on IncHI2 plasmids. In order to be able to analyse these plasmids in more detail, two different plasmids from a single farm ...
DOI:: 10.1016/j.vetmic.2015.09.001
: https://doi.org/10.1016/j.vetmic.2015.09.001

31. Comparative morpho-physiology of the metapleural glands of two Atta leaf-cutting ant queens nesting in clayish and organic soils

Author:: Alexsandro Santana Vieira; Maria Izabel Camargo-Mathias; Flavio Roces
Source:: Arthropod structure & development 2015 v.44 no.5 pp. 444-454
ISSN:: 1467-8039
Subject:: Atta sexdens rubropilosa; antibiotics; antiseptics; evolution; fungus gardens; leaf-cutting ants; microorganisms; nesting; organic matter; organic soils; pathogens; queen insects; risk; soil depth; soil horizons
Abstract:: ... Queens of leaf-cutting ants found their nests singly, each consisting of a vertical tunnel and a final horizontal chamber. Because of the claustral mode of nest founding, the queen and/or her initial fungus garden are exposed to threats imposed by several soil pathogens, and the antibiotic secretions produced by their metapleural glands are considered a main adaptation to deal with them. Nests of ...
DOI:: 10.1016/j.asd.2015.06.005
: https://doi.org/10.1016/j.asd.2015.06.005

32. Comparative proteomics analyses of Acinetobacter baumannii strains ATCC 17978 and AB5075 reveal the differential role of type II secretion system secretomes in lung colonization and ciprofloxacin resistance

Author:: Noha M. Elhosseiny; Nada B. Elhezawy; Ahmed S. Attia
Source:: Microbial pathogenesis 2019 v.128 pp. 20-27
ISSN:: 0882-4010
Subject:: Acinetobacter baumannii; antibiotic resistance; antibiotics; biofilm; ciprofloxacin; cross infection; enzymes; evolution; gentian violet; lungs; mice; minimum inhibitory concentration; models; pathogens; pneumonia; proteomics; resistance mechanisms; transposons; type II secretion system; virulence; virulent strains
Abstract:: ... Acinetobacter baumannii is an emerging nosocomial pathogen with alarming antibiotic resistance profiles. A better understanding of the virulence and resistance mechanisms of this pathogen is necessary for identifying new methods to combat its infections in a more efficient way. In this regard, the type II secretion system (T2SS) of A. baumannii is an attractive target majorly secreting lipid-metab ...
DOI:: 10.1016/j.micpath.2018.12.039
: https://doi.org/10.1016/j.micpath.2018.12.039

33. Comparing the selective and co-selective effects of different antimicrobials in bacterial communities

Author:: Aimee K. Murray; Lihong Zhang; Jason Snape; William H. Gaze
Source:: International journal of antimicrobial agents 2019 v.53 no.6 pp. 767-773
ISSN:: 0924-8579
Subject:: antibiotic resistance; antibiotic resistance genes; antibiotics; bacterial communities; benzalkonium chloride; ciprofloxacin; community structure; evolution; heavy metals; humans; metagenomics; quaternary ammonium compounds; resistance mechanisms; trimethoprim; wastewater
Abstract:: ... Bacterial communities are exposed to a cocktail of antimicrobial agents, including antibiotics, heavy metals and biocidal antimicrobials such as quaternary ammonium compounds (QACs). The extent to which these compounds may select or co-select for antimicrobial resistance (AMR) is not fully understood. In this study, human-associated, wastewater-derived bacterial communities were exposed to either ...
DOI:: 10.1016/j.ijantimicag.2019.03.001
PubMed:: 30885807
PubMed Central:: PMC6546120
: https://doi.org/10.1016/j.ijantimicag.2019.03.001

34. Competence in Streptococcus pneumoniae Is Regulated by the Rate of Ribosomal Decoding Errors

Author:: Kathleen E. Stevens; Diana Chang; Erin E. Zwack; Michael E. Sebert
Source:: mBio 2011 v.2 no.5 pp. e00071
ISSN:: 2150-7511
Subject:: Streptococcus pneumoniae; active sites; antibiotics; evolution; gene expression; genetic transformation; genome; humans; molecular chaperones; mutation; pathogens; peptides; pheromones; protein folding; protein synthesis; proteolysis; quorum sensing; respiratory system; ribosomal proteins; ribosomes; serine proteinases; signal transduction; translation (genetics)
Abstract:: ... Competence for genetic transformation in Streptococcus pneumoniae develops in response to accumulation of a secreted peptide pheromone and was one of the initial examples of bacterial quorum sensing. Activation of this signaling system induces not only expression of the proteins required for transformation but also the production of cellular chaperones and proteases. We have shown here that activi ...
DOI:: 10.1128/mBio.00071-11
PubMed:: 21933920
PubMed Central:: PMC3175624
: https://doi.org/10.1128/mBio.00071-11

35. Complete genome sequence and epigenetic profile of Bacillus velezensis UCMB5140 used for plant and crop protection in comparison with other plant-associated Bacillus strains

Author:: Oleg N. Reva; Safronova A. Larisa; Aneth D. Mwakilili; Donatha Tibuhwa; Sylvester Lyantagaye; Wai Yin Chan; Stefanie Lutz; Christian H. Ahrens; Joachim Vater; Rainer Borriss
Source:: Applied microbiology and biotechnology 2020 v.104 no.17 pp. 7643-7656
ISSN:: 0175-7598
Subject:: Bacillus velezensis; DNA; DNA methylation; adhesins; adhesion; antibiotics; biological control; biopesticides; biotechnology; epigenetics; evolution; gene expression; ligases; methyltransferases; nonribosomal peptides; nucleotide sequences; operon; plant growth-promoting rhizobacteria; plant protection; polypeptides
Abstract:: ... The application of biocontrol biopesticides based on plant growth–promoting rhizobacteria (PGPR), particularly members of the genus Bacillus, is considered a promising perspective to make agricultural practices sustainable and ecologically safe. Recent advances in genome sequencing by third-generation sequencing technologies, e.g., Pacific Biosciences’ Single Molecule Real-Time (PacBio SMRT) platf ...
DOI:: 10.1007/s00253-020-10767-w
: https://doi.org/10.1007/s00253-020-10767-w

36. The Complexity of the Holobiont in the Red Sea Coral Euphyllia paradivisa under Heat Stress

Author:: Dalit Meron; Keren Maor-Landaw; Gal Eyal; Hila Elifantz; Ehud Banin; Yossi Loya; Oren Levy
Source:: Microorganisms 2020 v.8 no.3 pp. -
ISSN:: 2076-2607
Subject:: alpha-Proteobacteria; antibiotics; corals; evolution; gene expression regulation; gene ontology; heat stress; microorganisms; physiology; symbionts; temperature; transcriptomics; Red Sea
Abstract:: ... The recognition of the microbiota complexity and their role in the evolution of their host is leading to the popularization of the holobiont concept. However, the coral holobiont (host and its microbiota) is still enigmatic and unclear. Here, we explore the complex relations between different holobiont members of a mesophotic coral Euphyllia paradivisa. We subjected two lines of the coral&m ...
DOI:: 10.3390/microorganisms8030372
: https://doi.org/10.3390/microorganisms8030372

37. Composition of nutrient media and temperature of cultivation imposes effect on the content of secondary metabolites of Nocardiopsis sp. isolated from a Siberian Cave

Author:: Denis V. Axenov-Gribanov; Maria M. Morgunova; Ulyana A. Vasilieva; Stanislav V. Gamaiunov; Maria E. Dmitrieva (Krasnova); Ekaterina V. Pereliaeva; Alexander Yu. Belyshenko; Andriy N. Luzhetskyy
Source:: 3 Biotech 2021 v.11 no.8 pp. 386
ISSN:: 2190-572X
Subject:: Bacillus subtilis; Nocardiopsis; Siberia; antibacterial properties; antibiotic resistance; antibiotics; antimicrobial peptides; asparagine; biosynthesis; ecosystems; evolution; human population; hydrophobicity; liquid chromatography; liquids; malt extract; mass spectrometry; secondary metabolites; temperature
Abstract:: ... Growth of human population leads to many global and medical problems. The problems include the crisis of health, antibiotic resistance, drug discovery, etc. Increasing antimicrobial resistance of microorganisms results in the need to screen natural products (incl. antibiotics and antimicrobial peptides) and their producers in different ecological niches. The purpose of this study was to estimate a ...
DOI:: 10.1007/s13205-021-02926-1
: https://doi.org/10.1007/s13205-021-02926-1

38. Confronting herbicide resistance with cooperative management

Author:: Jeffrey A Evans; Alwyn Williams; Aaron G Hager; Steven B Mirsky; Patrick J Tranel; Adam S Davis
Source:: Pest management science 2018 v.74 no.11 pp. 2424-2431
ISSN:: 1526-498X
Subject:: Amaranthus tuberculatus; antibiotics; collaborative management; evolution; farms; glyphosate; glyphosate resistance; herbicide-resistant weeds; models; pathogens
Abstract:: ... BACKGROUND: Resistance of pathogens and pests to antibiotics and pesticides worldwide is rapidly reaching critical levels. The common‐pool‐resource nature of this problem (i.e. whereby the susceptibility to treatment of target organisms is a shared resource) has been largely overlooked. Using herbicide‐resistant weeds as a model system, we developed a discrete‐time landscape‐scale simulation to in ...
DOI:: 10.1002/ps.5105
PubMed:: 29862629
PubMed Central:: PMC6220798
CHORUS:: 10.1002/ps.5105
Chorus Open Access:: 10.1002/ps.5105
: https://doi.org/10.1002/ps.5105

39. Could transformation mechanisms of acetylase-harboring pMdT1 plasmid be evaluated through proteomic tools in Escherichia coli?

Author:: Pedro Magalhães; Luís Pinto; Alexandre Gonçalves; José Eduardo Araújo; Hugo M. Santos; José Luis Capelo; Yolanda Saénz; María de Toro; Carmen Torres; Christophe Chambon; Michel Hébraud; Patrícia Poeta; Gilberto Igrejas
Source:: Journal of proteomics 2016 v.145 pp. 103-111
ISSN:: 1874-3919
Subject:: Escherichia coli; aminoglycosides; antibiotic resistance; antibiotics; bacteria; bioinformatics; electrophoresis; evolution; gastrointestinal system; gene transfer; genes; horizontal gene transfer; humans; liquid chromatography; matrix-assisted laser desorption-ionization mass spectrometry; plasmids; protein synthesis; proteins; proteome; proteomics; resistance mechanisms; tandem mass spectrometry
Abstract:: ... Escherichia coli is a commensal microorganism of the gastrointestinal tract of animals and humans and it is an excellent model organism for the study of antibiotic resistance mechanisms. The resistance transmission and other characteristics of bacteria are based on different types of gene transfer occurring throughout the bacterial evolution. One of which is horizontal gene transfer that allows us ...
DOI:: 10.1016/j.jprot.2016.03.042
: https://doi.org/10.1016/j.jprot.2016.03.042

40. Critical knowledge gaps and research needs related to the environmental dimensions of antibiotic resistance

Author:: D.G. Joakim Larsson; Antoine Andremont; Johan Bengtsson-Palme; Kristian Koefoed Brandt; Ana Maria de Roda Husman; Patriq Fagerstedt; Jerker Fick; Carl-Fredrik Flach; William H. Gaze; Makoto Kuroda; Kristian Kvint; Ramanan Laxminarayan; Celia M. Manaia; Kaare Magne Nielsen; Laura Plant; Marie-Cécile Ploy; Carlos Segovia; Pascal Simonet; Kornelia Smalla; Jason Snape; Edward Topp; Arjon J. van Hengel; David W. Verner-Jeffreys; Marko P.J. Virta; Elizabeth M. Wellington; Ann-Sofie Wernersson
Source:: Environment international 2018 v.117 pp. 132-138
ISSN:: 0160-4120
Subject:: Internet; animal and human health; antibiotic resistance; antibiotics; bacteria; evolution; experts; pathogens; risk; scientists; stakeholders
Abstract:: ... There is growing understanding that the environment plays an important role both in the transmission of antibiotic resistant pathogens and in their evolution. Accordingly, researchers and stakeholders world-wide seek to further explore the mechanisms and drivers involved, quantify risks and identify suitable interventions. There is a clear value in establishing research needs and coordinating effo ...
DOI:: 10.1016/j.envint.2018.04.041
: https://doi.org/10.1016/j.envint.2018.04.041

41. Culturing Ancient Bacteria Carrying Resistance Genes from Permafrost and Comparative Genomics with Modern Isolates

Author:: Pamela Afouda; Grégory Dubourg; Anthony Levasseur; Pierre-Edouard Fournier; Jeremy Delerce; Oleg Mediannikov; Seydina M. Diene; Daniel Nahon; Didier Bourlès; Jean-Marc Rolain; Didier Raoult
Source:: Microorganisms 2020 v.8 no.10 pp. -
ISSN:: 2076-2607
Subject:: Achromobacter; Brevundimonas aurantiaca; Gram-negative bacteria; Janibacter; Kocuria rhizophila; Microbacterium; antibiotic resistance; antibiotic resistance genes; antibiotics; biosphere; dynamics; evolution; genomics; humans; new species; permafrost; resistance mechanisms; sampling; single nucleotide polymorphism; strains; variability; viability
Abstract:: ... Long considered to be a consequence of human antibiotics use by deduction, antibiotic resistance mechanisms appear to be in fact a much older phenomenon as antibiotic resistance genes have previously been detected from millions of year-old permafrost samples. As these specimens guarantee the viability of archaic bacteria, we herein propose to apply the culturomics approach to recover the bacterial ...
DOI:: 10.3390/microorganisms8101522
: https://doi.org/10.3390/microorganisms8101522

42. Cysteine-stabilized αβ defensins: From a common fold to antibacterial activity

Author:: Renata de Oliveira Dias; Octavio Luiz Franco
Source:: Peptides 2015 v.72 pp. 64-72
ISSN:: 0196-9781
Subject:: amino acids; antibacterial properties; antibiotics; antimicrobial peptides; bacteria; disulfide bonds; evolution; fungi; invertebrates; mechanism of action
Abstract:: ... Antimicrobial peptides (AMPs) seem to be promising alternatives to common antibiotics, which are facing increasing bacterial resistance. Among them are the cysteine-stabilized αβ defensins. These peptides are small, with a length ranging from 34 to 54 amino acid residues, cysteine-rich and extremely stable, normally composed of an α-helix and three β-strands stabilized by three or four disulfide b ...
DOI:: 10.1016/j.peptides.2015.04.017
: https://doi.org/10.1016/j.peptides.2015.04.017

43. Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins

Author:: Weinreich, Daniel M.; Delaney, Nigel F.; DePristo, Mark A.; Hartl, Daniel L.
Source:: Science 2006 v.312 no.5770 pp. 111-114
ISSN:: 0036-8075
Subject:: alleles; antibiotics; drug resistance; evolution; missense mutation; pleiotropy; point mutation; proteins
Abstract:: ... Five point mutations in a particular {szligbeta}-lactamase allele jointly increase bacterial resistance to a clinically important antibiotic by a factor of [approximately]100,000. In principle, evolution to this high-resistance {szligbeta}-lactamase might follow any of the 120 mutational trajectories linking these alleles. However, we demonstrate that 102 trajectories are inaccessible to Darwinian ...
DOI:: 10.1126/science.1123539
: https://doi.org/10.1126/science.1123539

44. Detection of Extended-Spectrum β-Lactamase-Producing Escherichia coli Using Infrared Microscopy and Machine-Learning Algorithms

Author:: Uraib Sharaha; Eladio Rodriguez-Diaz; Orli Sagi; Klaris Riesenberg; Itshak Lapidot; Yoram Segal; Irving J. Bigio; Mahmoud Huleihel; Ahmad Salman
Source:: Analytical chemistry 2019 v.91 no.3 pp. 2525-2530
ISSN:: 1520-6882
Subject:: algorithms; antibiotics; beta-lactamase bacteria; evolution; microscopy; mortality; multiple drug resistance; multivariate analysis; patients; rapid methods; spectroscopy; urinary tract; urinary tract diseases; urine; uropathogenic Escherichia coli
Abstract:: ... The spread of multidrug resistant bacteria has become a global concern. One of the most important and emergent classes of multidrug-resistant bacteria is extended-spectrum β-lactamase-producing bacteria (ESBL-positive = ESBL⁺). Due to widespread and continuous evolution of ESBL-producing bacteria, they become increasingly resistant to many of the commonly used antibiotics, leading to an increase i ...
DOI:: 10.1021/acs.analchem.8b05497
: https://doi.org/10.1021/acs.analchem.8b05497

45. Development of a Convergent Enantioselective Synthetic Route to (−)-Myrocin G

Author:: Martin Tomanik; Christos Economou; Madeline C. Frischling; Mengzhao Xue; Victoria A. Marks; Brandon Q. Mercado; Seth B. Herzon
Source:: Journal of organic chemistry 2020 v.85 no.14 pp. 8952-8989
ISSN:: 1520-6904
Subject:: DNA; Lewis acids; antibiotics; bioactive properties; chemical reactions; crosslinking; enantioselectivity; evolution; fungi; isomers; mechanism of action; metabolites; organic chemistry
Abstract:: ... Myrocins are a family of antiproliferative antibiotic fungal metabolites possessing a masked electrophilic cyclopropane. Preliminary chemical reactivity studies imputed the bioactivity of these natural products to a DNA cross-linking mechanism, but this hypothesis was not confirmed by studies with native DNA. We recently reported a total synthesis of (−)-myrocin G (4), the putative active form of ...
DOI:: 10.1021/acs.joc.0c00891
: https://doi.org/10.1021/acs.joc.0c00891

46. Development of a poly(ether urethane) system for the controlled release of two novel anti-biofilm agents based on gallium or zinc and its efficacy to prevent bacterial biofilm formation

Author:: Hongyan Ma; Erica T. Darmawan; Min Zhang; Lei Zhang; James D. Bryers
Source:: Journal of controlled release 2013 v.172 no.3 pp. 1035-1044
ISSN:: 0168-3659
Subject:: Pseudomonas aeruginosa; Staphylococcus epidermidis; antibiotics; bacteria; biofilm; cytotoxicity; endotoxins; ethylene glycol; evolution; gallium; in vivo studies; microbial growth; polymers; protoporphyrin; siderophores; therapeutics; urethane; zinc
Abstract:: ... Traditional antibiotic therapy to control medical device-based infections typically fails to clear biofilm infections and may even promote the evolution of antibiotic resistant species. We report here the development of two novel antibiofilm agents; gallium (Ga) or zinc (Zn) complexed with protoporphyrin IX (PP) or mesoprotoporphyrin IX (MP) that are both highly effective in negating suspended bac ...
DOI:: 10.1016/j.jconrel.2013.10.005
PubMed:: 24140747
PubMed Central:: PMC3858484
: https://doi.org/10.1016/j.jconrel.2013.10.005

47. Differences in recipient ability of uropathogenic Escherichia coli strains in relation with their pathogenic potential

Author:: Marina V. Kuznetsova; Irina L. Maslennikova; Julia S. Pospelova; Darja Žgur Bertok; Marjanca Starčič Erjavec
Source:: Infection, genetics, and evolution 2022 v.97 pp. 105160
ISSN:: 1567-1348
Subject:: antibiotics; bacteriocins; biofilm; biomass; evolution; infection; plankton; plasmids; urinary tract; uropathogenic Escherichia coli; virulence
Abstract:: ... Conjugation is recognized as a mechanism driving dissemination of antibacterial resistances and virulence factors among bacteria. In the presented work conjugative transfer frequency into clinical uropathogenic Escherichia coli strains (UPEC) isolated from patients with symptomatic urinary tract infections was investigated. From 93 obtained UPEC strains only 29 were suitable for conjugation experi ...
DOI:: 10.1016/j.meegid.2021.105160
: https://doi.org/10.1016/j.meegid.2021.105160

48. Disk prediffusion is a reliable method for testing colistin susceptibility in porcine E. coli strains

Author:: Boyen, F.; Vangroenweghe, F.; Butaye, P.; De Graef, E.; Castryck, F.; Heylen, P.; Vanrobaeys, M.; Haesebrouck, F.
Source:: Veterinary microbiology 2010 v.144 no.3-4 pp. 359-362
ISSN:: 0378-1135
Subject:: antibiotic resistance; antibiotics; minimum inhibitory concentration; evolution; strain differences; animal pathogenic bacteria; antimicrobial peptides; swine; pathogenicity; reliability; agar; accuracy; Escherichia coli
Abstract:: ... During the last few years, acquired resistance to colistin in Escherichia coli, but also in other bacterial species, has been reported. It has been shown that the disk diffusion test is not a reliable method for the detection of this resistance. Therefore, there is a need for a reliable and cheap test to determine colistin susceptibility of pathogenic E. coli strains. In the current research, the ...
DOI:: 10.1016/j.vetmic.2010.01.010
: https://doi.org/10.1016/j.vetmic.2010.01.010

49. Dissecting the roles of conductive materials in attenuating antibiotic resistance genes: Evolution of physiological features and bacterial community

Author:: Qi Zhao; Wanqian Guo; Haichao Luo; Huazhe Wang; Taiping Yu; Banghai Liu; Qishi Si; Nanqi Ren
Source:: Journal of hazardous materials 2022 v.438 pp. 129411
ISSN:: 0304-3894
Subject:: anaerobic digesters; antibiotic resistance; antibiotics; bacterial communities; cell communication; evolution; iron; magnetite; oxidative stress; secretion; stress response; sulfamethoxazole; wastewater; wastewater treatment
Abstract:: ... Supplying conductive materials (CMs) into anaerobic bioreactors is considered as a promising technology for antibiotic wastewater treatment. However, whether and how CMs influence antibiotic resistance genes (ARGs) spread remains poorly known. Here, we investigated the effects of three CMs, i.e., magnetite, activated carbon (AC), and zero valent iron (ZVI), on ARGs dissemination during treating su ...
DOI:: 10.1016/j.jhazmat.2022.129411
: https://doi.org/10.1016/j.jhazmat.2022.129411

50. Distribution and transfer of antibiotic resistance genes in different soil–plant systems

Author:: Yuan Zhang; Jie Zhou; Jian Wu; Qianwen Hua; Canxin Bao
Source:: Environmental science and pollution research 2022 v.29 no.39 pp. 59159-59172
ISSN:: 0944-1344
Subject:: Brassica rapa subsp. chinensis; Echinochloa crus-galli; Firmicutes; animal manures; antibiotic resistance; antibiotics; bacterial communities; corn; dogs; endophytes; evolution; food chain; human health; lettuce; phyllosphere; research; rhizosphere; soil; soil pollution; tail
Abstract:: ... The extensive application of farm manure that is contaminated with pharmaceutical antibiotics not only causes substantial soil pollution but additionally leads to the input of antibiotic resistance genes (ARGs) into the soil. These ARGs would proliferate and affect human health via the food chain. The effects of cultivated crops and wild plants on ARGs in rhizosphere soil are unclear. Therefore, w ...
DOI:: 10.1007/s11356-021-17465-8
: https://doi.org/10.1007/s11356-021-17465-8

51. Distribution of antibiotic resistance and virulence factors among the bacteria isolated from diseased Etroplus suratensis

Author:: Aswani Ravi; Soumya Das; Jasim Basheer; Aswathy Chandran; Chinnu Benny; Sindhura Somaraj; Sebastian Korattiparambil Sebastian; Jyothis Mathew; Radhakrishnan Edayileveettil Krishnankutty
Source:: 3 Biotech 2019 v.9 no.4 pp. 138
ISSN:: 2190-572X
Subject:: Etroplus suratensis; antibiotic resistance; antibiotics; bacteria; deoxyribonucleases; evolution; fish; genes; hemolysins; hemolysis; monitoring; polymerase chain reaction; screening; virulence
Abstract:: ... Considering the emerging concern with the antimicrobial resistance (AMR) evolution, the study has been designed to identify the antibiotic resistance and virulence properties of culturable bacteria isolated from the diseased fish Etroplus suratensis. This has resulted in the purification of 18 morphologically distinct bacterial isolates which were identified by both biochemical and molecular metho ...
DOI:: 10.1007/s13205-019-1654-3
PubMed:: 30944785
PubMed Central:: PMC6419682
: https://doi.org/10.1007/s13205-019-1654-3

52. Diversity and variation in antimicrobial susceptibility patterns over time in Mycoplasma agalactiae isolates collected from sheep and goats in France

Author:: F. Poumarat; A.V. Gautier‐Bouchardon; D. Bergonier; E. Gay; F. Tardy
Source:: Journal of applied microbiology 2016 v.120 no.5 pp. 1208-1218
ISSN:: 1364-5072
Subject:: Mycoplasma agalactiae; Mycoplasma bovis; agalactia; antibiotic resistance; antibiotics; cattle; dairy industry; evolution; financial economics; fluoroquinolones; genetic background; genetic relationships; genetic variation; goats; macrolides; minimum inhibitory concentration; pathogens; sheep; France
Abstract:: ... AIMS: Mycoplasma agalactiae is responsible for Contagious Agalactia, a severe syndrome affecting small ruminants worldwide and resulting in significant economic losses in countries with an important dairy industry. The aim of this study was to examine the antimicrobial susceptibility patterns of M. agalactiae isolates in France, their evolution over the last 25 years and their relationships with t ...
DOI:: 10.1111/jam.13083
: https://doi.org/10.1111/jam.13083

53. Does Soil Contribute to the Human Gut Microbiome?

Author:: Winfried E.H. Blum; Sophie Zechmeister-Boltenstern; Katharina M. Keiblinger
Source:: Microorganisms 2019 v.7 no.9 pp. -
ISSN:: 2076-2607
Subject:: agrochemicals; antibiotics; beneficial microorganisms; digestive system; endophytes; epiphytes; evolution; feces; genes; humans; hygiene; intestinal microorganisms; lifestyle; low fiber diet; microbiome; processed foods; rural areas; soil; soil management; soil microorganisms; species diversity; urban areas; urbanization
Abstract:: ... Soil and the human gut contain approximately the same number of active microorganisms, while human gut microbiome diversity is only 10% that of soil biodiversity and has decreased dramatically with the modern lifestyle. We tracked relationships between the soil microbiome and the human intestinal microbiome. We propose a novel environmental microbiome hypothesis, which implies that a close linkage ...
DOI:: 10.3390/microorganisms7090287
PubMed:: 31450753
PubMed Central:: PMC6780873
: https://doi.org/10.3390/microorganisms7090287

54. Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3″)-Ii/AAC(6′)-IId from Serratia marcescens

Author:: Keith D. Green; Sylvie Garneau-Tsodikova
Source:: Biochimie 2013 v.95 pp. 1319-1325
ISSN:: 0300-9084
Subject:: Serratia marcescens; acetylation; aminoglycosides; antibiotics; bacteria; enteropathogens; enzymes; evolution; genes; humans; phosphorylation; resistance mechanisms
Abstract:: ... Aminoglycosides (AGs) are broad-spectrum antibiotics whose constant use and presence in growth environments has led bacteria to develop resistance mechanisms to aid in their survival. A common mechanism of resistance to AGs is their chemical modification (nucleotidylation, phosphorylation, or acetylation) by AG-modifying enzymes (AMEs). Through evolution, fusion of two AME-encoding genes has resul ...
DOI:: 10.1016/j.biochi.2013.02.011
PubMed:: 23485681
PubMed Central:: PMC3646955
: https://doi.org/10.1016/j.biochi.2013.02.011

55. Drug efflux pump deficiency and drug target resistance masking in growing bacteria

Author:: Fange, David; Nilsson, Karin; Tenson, Tanel; Ehrenberg, Måns
Source:: Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.20 pp. 8215-8220
ISSN:: 0027-8424
Subject:: antibiotics; bacteria; culture media; drugs; evolution; mutants; mutation; pathogens; transporters
Abstract:: ... Recent experiments have shown that drug efflux pump deficiency not only increases the susceptibility of pathogens to antibiotics, but also seems to "mask" the effects of mutations, that decrease the affinities of drugs to their intracellular targets, on the growth rates of drug-exposed bacteria. That is, in the presence of drugs, the growth rates of drug-exposed WT and target mutated strains are t ...
DOI:: 10.1073/pnas.0811514106
PubMed:: 19416855
PubMed Central:: PMC2688851
: https://doi.org/10.1073/pnas.0811514106

56. E622, a Miniature, Virulence-Associated Mobile Element

Author:: John Stavrinides; Morgan W. B. Kirzinger; Federico C. Beasley; David S. Guttman
Source:: Journal of bacteriology 2012 v.194 no.2 pp. 509-517
ISSN:: 0021-9193
Subject:: Cyanothece; Erwinia; Nostoc; Pantoea; Pseudomonas syringae; Salmonella; Shewanella; antibiotic resistance; antibiotics; bacteria; bacteriology; enzymes; evolution; operon; surveys; terminal repeat sequences; toxins; transposons; virulence
Abstract:: ... Miniature inverted terminal repeat elements (MITEs) are nonautonomous mobile elements that have a significant impact on bacterial evolution. Here we characterize E622, a 611-bp virulence-associated MITE from Pseudomonas syringae, which contains no coding region but has almost perfect 168-bp inverted repeats. Using an antibiotic coupling assay, we show that E622 is transposable and can mobilize an ...
DOI:: 10.1128/JB.06211-11
PubMed:: 22081398
PubMed Central:: PMC3256676
: https://doi.org/10.1128/JB.06211-11

57. Effects of various antibiotics on aerobic nitrogen removal and antibiotic degradation performance: Mechanism, degradation pathways, and microbial community evolution

Author:: Donghui Liang; Yongyou Hu; Ruzhen Huang; Jianhua Cheng; Yuancai Chen
Source:: Journal of hazardous materials 2022 v.422 pp. 126818
ISSN:: 0304-3894
Subject:: Achromobacter; activated sludge; amination; antibiotic resistance; antibiotics; biofilm; ciprofloxacin; cleavage (chemistry); denitrification; evolution; hydroxylation; methylation; microbial communities; nitrification; nitrogen; pollutants; sulfamethoxazole; total nitrogen; trimethoprim
Abstract:: ... Little information about the selective stress of various antibiotics and how they influence different stages of aerobic nitrogen removal is available. A long-term aerobic nitrogen removal-moving bed biofilm reactor was established by the inoculation of Achromobacter sp. JL9, capable of heterotrophic nitrification and aerobic denitrification, and aerobic activated sludge. The nitrogen removal and a ...
DOI:: 10.1016/j.jhazmat.2021.126818
: https://doi.org/10.1016/j.jhazmat.2021.126818

58. Emerging evolutionary paradigms in antibiotic discovery

Author:: Marc G. Chevrette; Cameron R. Currie
Source:: Journal of industrial microbiology & biotechnology 2019 v.46 no.3-4 pp. 257-271
ISSN:: 1367-5435
Subject:: Actinobacteria; antibiotics; biochemical pathways; ecology; evolution; microorganisms; pathogens; secondary metabolites; toxicity
Abstract:: ... Antibiotics revolutionized medicine and remain its cornerstone. Despite their global importance and the continuous threat of resistant pathogens, few antibiotics have been discovered in recent years. Natural products, especially the secondary metabolites of Actinobacteria, have been the traditional discovery source of antibiotics. In nature, the chemistry of antibiotic natural products is shaped b ...
DOI:: 10.1007/s10295-018-2085-6
: https://doi.org/10.1007/s10295-018-2085-6

59. Energy- and cost-effective non-sterilized fermentation of 2,3-butanediol by an engineered Klebsiella pneumoniae OU7 with an anti-microbial contamination system

Author:: Ze-Wang Guo; Xiao-Yang Ou; Pei Xu; Hui-Fang Gao; Liao-Yuan Zhang; Min-Hua Zong; Wen-Yong Lou
Source:: Green chemistry 2020 v.22 no.24 pp. 8584-8593
ISSN:: 1463-9270
Subject:: Klebsiella pneumoniae; antibiotic resistance; antibiotics; biosynthesis; cost effectiveness; energy; evolution; fermentation; green chemistry; labor; microbial contamination; nitrogen; pathogenicity; phosphorus; risk; urea
Abstract:: ... Microbial contamination is a serious challenge that needs to be overcome for the successful biosynthesis of 2,3-butanediol (2,3-BD). However, traditional strategies such as antibiotic administration or sterilization are costly, have high energy demands, and may increase the risk of antibiotic resistance. Here, we intend to develop a robust strategy to achieve non-sterilized fermentation of 2,3-BD. ...
DOI:: 10.1039/d0gc03044a
: https://doi.org/10.1039/d0gc03044a

60. Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy

Author:: Lu, Timothy K.; Collins, James J.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.12 pp. 4629-4634
ISSN:: 0027-8424
Subject:: Escherichia coli; adjuvants; aminoglycosides; antibiotic resistance; antibiotics; bacteria; bacteriophages; beta-lactams; biofilm; drugs; evolution; gene targeting; genes; mice; proteins; quinolones; synthetic biology; therapeutics
Abstract:: ... Antimicrobial drug development is increasingly lagging behind the evolution of antibiotic resistance, and as a result, there is a pressing need for new antibacterial therapies that can be readily designed and implemented. In this work, we engineered bacteriophage to overexpress proteins and attack gene networks that are not directly targeted by antibiotics. We show that suppressing the SOS network ...
DOI:: 10.1073/pnas.0800442106
PubMed:: 19255432
PubMed Central:: PMC2649960
: https://doi.org/10.1073/pnas.0800442106

61. Enhancing recovery performance of the toluene-removing biofilter after the short/long interference-shutdown period

Author:: Yuxi Yan; Bixi Zhao; Jiao Yang; Jing Zhang; Shunyi Li; Yu Xia
Source:: Bioresource technology 2022 v.346 pp. 126592
ISSN:: 0960-8524
Subject:: Pseudomonas putida; antibiotics; biodegradation; biofilters; drug resistance; evolution; industrial applications; microbial communities; polyethylene; risk; starvation; technology; tinidazole
Abstract:: ... In this study, the feasibility of three methods on enhancing the recovery performance of biofilter after the interference and starvation periods was evaluated. Results show that despite the pressure drop risk, supplementation of 7.5% (w/v) Polyethylene glycol-600 (PEG-600) resulted in quick recovery on removal efficiency in both short- and long-term interference shutdown experiments. Tinidazole Ta ...
DOI:: 10.1016/j.biortech.2021.126592
: https://doi.org/10.1016/j.biortech.2021.126592

62. Environmentally friendly approaches to genetic engineering

Author:: Daniell, H.
Source:: In vitro cellular & developmental biology 1999 v.35 no.5 pp. 361-368
ISSN:: 1054-5476
Subject:: maternal effect; antibiotics; evolution; transgenic plants; gene flow; Bacillus thuringiensis; genes; genetic engineering; bacterial toxins; crystal proteins; environmental impact; nontarget organisms; wild relatives; pollen; inheritance (genetics); adverse effects; chloroplasts; drug resistance
DOI:: 10.1007/s11627-999-0049-2
: https://doi.org/10.1007/s11627-999-0049-2

63. Epidemiology of asexuality induced by the endosymbiotic Wolbachia across phytophagous wasp species: host plant specialization matters

Author:: T. Boivin; H. Henri; F. Vavre; C. Gidoin; P. Veber; J.‐N. Candau; E. Magnoux; A. Roques; M.‐A. Auger‐Rozenberg
Source:: Molecular ecology 2014 v.23 no.9 pp. 2362-2375
ISSN:: 0962-1083
Subject:: arrhenotoky; insects; Vespidae; Rickettsia; sex ratio; thelytoky; screening; females; Megastigmus; Wolbachia; community structure; evolution; host plants; hybridization; mutation; insect communities; epidemiology; Arsenophonus; antibiotics; endosymbionts; surveys
Abstract:: ... Among eukaryotes, sexual reproduction is by far the most predominant mode of reproduction. However, some systems maintaining sexuality appear particularly labile and raise intriguing questions on the evolutionary routes to asexuality. Thelytokous parthenogenesis is a form of spontaneous loss of sexuality leading to strong distortion of sex ratio towards females and resulting from mutation, hybridi ...
DOI:: 10.1111/mec.12737
PubMed:: 24673824
: https://doi.org/10.1111/mec.12737

64. Evolution of Antibacterial Drug Screening Methods: Current Prospects for Mycobacteria

Author:: Clara M. Bento; Maria Salomé Gomes; Tânia Silva
Source:: Microorganisms 2021 v.9 no.12 pp. -
ISSN:: 2076-2607
Subject:: antibiotics; automation; evolution; prediction
Abstract:: ... The increasing resistance of infectious agents to available drugs urges the continuous and rapid development of new and more efficient treatment options. This process, in turn, requires accurate and high-throughput techniques for antimicrobials’ testing. Conventional methods of drug susceptibility testing (DST) are reliable and standardized by competent entities and have been thoroughly applied to ...
DOI:: 10.3390/microorganisms9122562
: https://doi.org/10.3390/microorganisms9122562

65. The Evolution of Cefotaximase Activity in the TEM β-Lactamase

Author:: Manoj Kumar Singh; Brian N. Dominy
Source:: Journal of molecular biology 2012 v.415 no.1 pp. 205-220
ISSN:: 0022-2836
Subject:: antibiotics; beta-lactamase; binding sites; catalytic activity; drug resistance; evolution; mechanics; mutants; mutation
Abstract:: ... The development of a molecular-level understanding of drug resistance through β-lactamase is critical not only in designing newer-generation antibacterial agents but also in providing insight into the evolutionary mechanisms of enzymes in general. In the present study, we have evaluated the effect of four drug resistance mutations (A42G, E104K, G238S, and M182T) on the cefotaximase activity of the ...
DOI:: 10.1016/j.jmb.2011.10.041
PubMed:: 22075446
: https://doi.org/10.1016/j.jmb.2011.10.041

66. Evolution of Resistance to Quorum-Sensing Inhibitors

Author:: Vipin C. Kalia; Thomas K. Wood; Prasun Kumar
Source:: Microbial ecology 2014 v.68 no.1 pp. 13-23
ISSN:: 0095-3628
Subject:: antibiotics; bacteria; bacterial infections; evolution; humans; microbial growth; morbidity; mortality; pathogenicity; pathogens; quorum sensing; receptors
Abstract:: ... The major cause of mortality and morbidity in human beings is bacterial infection. Bacteria have developed resistance to most of the antibiotics primarily due to large-scale and “indiscriminate” usage. The need is to develop novel mechanisms to treat bacterial infections. The expression of pathogenicity during bacterial infections is mediated by a cell density-dependent phenomenon known as quorum ...
DOI:: 10.1007/s00248-013-0316-y
PubMed:: 24194099
PubMed Central:: PMC4012018 [Available on 07/01/15]
: https://doi.org/10.1007/s00248-013-0316-y

67. Evolution of extensively drug-resistant Mycobacterium tuberculosis from a susceptible ancestor in a single patient

Author:: Vegard Eldholm; Gunnstein Norheim; Bent von der Lippe; Wibeke Kinander; Ulf R Dahle; Dominique A Caugant; Turid Mannsåker; Anne Torunn Mengshoel; Anne Ma Dyrhol-Riise; Francois Balloux
Source:: Genome biology 2014 v.15 no.11 pp. 490
ISSN:: 1474-760X
Subject:: Mycobacterium tuberculosis; antibiotic resistance; antibiotics; clones; drugs; evolution; gene expression; gene expression regulation; genetic background; genetic recombination; nucleotide sequences; operon; patients; single nucleotide polymorphism; tuberculosis
Abstract:: ... BACKGROUND: Mycobacterium tuberculosis is characterized by a low mutation rate and a lack of genetic recombination. Yet, the rise of extensively resistant strains paints a picture of a microbe with an impressive adaptive potential. Here we describe the first documented case of extensively drug-resistant tuberculosis evolved from a susceptible ancestor within a single patient. RESULTS: Genome seque ...
DOI:: 10.1186/s13059-014-0490-3
PubMed:: 25418686
PubMed Central:: PMC4223161
: https://doi.org/10.1186/s13059-014-0490-3

68. Evolution of pathogens in a man-made world

Author:: LEBARBENCHON, CAMILLE; BROWN, SAM P.; POULIN, ROBERT; GAUTHIER-CLERC, MICHEL; THOMAS, FRÉDÉRIC
Source:: Molecular ecology 2008 v.17 no.1 pp. 475-484
ISSN:: 0962-1083
Subject:: anthropogenic activities; antibiotics; biodiversity; climate change; ecologists; economic development; evolution; habitat fragmentation; humans; parasites; pathogens; planning; pollution; public health; researchers; vaccines; virulence; wildlife management
Abstract:: ... Human activities have resulted in substantial, large-scale environmental modifications, especially in the past century. Ecologists and evolutionary biologists are increasingly coming to realize that parasites and pathogens, like free-living organisms, evolve as the consequence of these anthropogenic changes. Although this area now commands the attention of a variety of researchers, a broad predict ...
DOI:: 10.1111/j.1365-294X.2007.03375.x
PubMed:: 18173509
: https://doi.org/10.1111/j.1365-294X.2007.03375.x

69. Evolution of structural fitness and multifunctional aspects of mycobacterial RND family transporters

Author:: Padmani Sandhu; Yusuf Akhter
Source:: Archives of microbiology 2018 v.200 no.1 pp. 19-31
ISSN:: 0302-8933
Subject:: Mycobacterium tuberculosis; antibiotics; bacteria; drugs; evolution; multiple drug resistance; nodulation; pathogens; transporters
Abstract:: ... Drug resistance is a major concern due to the evolution and emergence of pathogenic bacterial strains with novel strategies to resist the antibiotics in use. Mycobacterium tuberculosis (Mtb) is one of such pathogens with reported strains, which are not treatable with any of the available anti-TB drugs. This scenario has led to the need to look for some novel drug targets in Mtb, which may be explo ...
DOI:: 10.1007/s00203-017-1434-6
: https://doi.org/10.1007/s00203-017-1434-6

70. Evolution of surviving Streptoccocus pyogenes from pharyngotonsillitis patients submit to multiple cycles of antimicrobial photodynamic therapy

Author:: Jennifer Machado Soares; Natalia Mayumi Inada; Vanderlei Salvador Bagnato; Kate Cristina Blanco
Source:: Journal of photochemistry and photobiology 2020 v.210 pp. 111985
ISSN:: 1011-1344
Subject:: Streptococcus pyogenes; adhesion; antibiotics; biofilm; biomedical research; curcumin; evolution; mortality; photobiology; photochemistry; photochemotherapy; photosensitizing agents
Abstract:: ... It is estimated over 600 million pharyngotonsillitis (PT) cases worldwide per year and 30% of this total are caused by Streptococcus pyogenes with standard antibiotic treatment. Antimicrobial Photodynamic Therapy (aPDT) has been studied for the clinical research in infectious diseases. The study aim was to analyze the evolution of aPDT on inactivation of clinical strains of multiple cycles. S. pyo ...
DOI:: 10.1016/j.jphotobiol.2020.111985
: https://doi.org/10.1016/j.jphotobiol.2020.111985

71. Evolutionary Mechanisms Shaping the Maintenance of Antibiotic Resistance

Author:: Paulo Durão; Roberto Balbontín; Isabel Gordo
Source:: Trends in microbiology 2018 v.26 no.8 pp. 677-691
ISSN:: 0966-842X
Subject:: antibiotic resistance; antibiotics; bacteria; drugs; epistasis; evolution; mutation; resistance genes
Abstract:: ... Antibiotics target essential cellular functions but bacteria can become resistant by acquiring either exogenous resistance genes or chromosomal mutations. Resistance mutations typically occur in genes encoding essential functions; these mutations are therefore generally detrimental in the absence of drugs. However, bacteria can reduce this handicap by acquiring additional mutations, known as compe ...
DOI:: 10.1016/j.tim.2018.01.005
: https://doi.org/10.1016/j.tim.2018.01.005

72. The Exoskeleton of Bacterial Cells (the Sacculus): Still a Highly Attractive Target for Antibacterial Agents That Will Last For a Long Time

Author:: Arthur L. Koch
Source:: Critical reviews in microbiology 2000 v.26 no.1 pp. 1-35
ISSN:: 1549-7828
Subject:: antibiotic resistance; antibiotics; bacteria; biophysics; cell walls; chemical bonding; cytoplasm; drug therapy; evolution; exoskeleton; metabolism; mutation; osmotic pressure
Abstract:: ... Most bacteria are entirely surrounded by a strong cell wall held together by covalent bonds of strength similar to those holding the atoms in a diamond together. This exoskeleton is a coat of armor or corset and is usually called a sacculus. It protects the bacterium from the stresses resulting from the higher osmotic pressure of the cytoplasm when compared with its environment. This strategy of c ...
DOI:: 10.1080/10408410091154165
: https://doi.org/10.1080/10408410091154165

73. Exploring the potential impact of an expanded genetic code on protein function

Author:: Han Xiao; Fariborz Nasertorabi; Sei-hyun Choi; Gye Won Han; Sean A. Reed; Raymond C. Stevens; Peter G. Schultz
Source:: Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.22 pp. 6961-6966
ISSN:: 0027-8424
Subject:: amino acids; antibiotics; beta-lactamase; catalytic activity; evolution; genetic code; mutants; mutation
Abstract:: ... With few exceptions, all living organisms encode the same 20 canonical amino acids; however, it remains an open question whether organisms with additional amino acids beyond the common 20 might have an evolutionary advantage. Here, we begin to test that notion by making a large library of mutant enzymes in which 10 structurally distinct noncanonical amino acids were substituted at single sites ran ...
DOI:: 10.1073/pnas.1507741112
PubMed:: 26038548
PubMed Central:: PMC4460475
: https://doi.org/10.1073/pnas.1507741112

74. Extrachromosomal and integrated genetic elements in Clostridium difficile

Author:: Jacob Amy; Priscilla Johanesen; Dena Lyras
Source:: Plasmid 2015 v.80 pp. 97-110
ISSN:: 0147-619X
Subject:: Clostridium difficile; antibiotic resistance; antibiotics; bacteria; cross infection; digestive system diseases; evolution; interspersed repetitive sequences; pathogens; patients; phenotype; plasmids; sequence analysis; therapeutics
Abstract:: ... Clostridium difficile is a major nosocomial pathogen, causing gastrointestinal disease in patients undergoing antibiotic therapy. This bacterium contains many extrachromosomal and integrated genetic elements, with recent genomic work giving new insights into their variability and distribution. This review summarises research conducted in this area over the last 30 years and includes a discussion o ...
DOI:: 10.1016/j.plasmid.2015.04.006
: https://doi.org/10.1016/j.plasmid.2015.04.006

75. Fitness trade‐offs explain low levels of persister cells in the opportunistic pathogen Pseudomonas aeruginosa

Author:: Kristine Stepanyan; Tom Wenseleers; Edgar A. Duéñez‐Guzmán; Frédéric Muratori; Bram Van den Bergh; Natalie Verstraeten; Luc De Meester; Kevin J. Verstrepen; Maarten Fauvart; Jan Michiels
Source:: Molecular ecology 2015 v.24 no.7 pp. 1572-1583
ISSN:: 0962-1083
Subject:: Pseudomonas aeruginosa; antibiotics; evolution; humans; infectious diseases; models; pathogens
Abstract:: ... Microbial populations often contain a fraction of slow‐growing persister cells that withstand antibiotics and other stress factors. Current theoretical models predict that persistence levels should reflect a stable state in which the survival advantage of persisters under adverse conditions is balanced with the direct growth cost impaired under favourable growth conditions, caused by the nonreplic ...
DOI:: 10.1111/mec.13127
: https://doi.org/10.1111/mec.13127

76. Francisella noatunensis subsp. noatunensis replicates within Atlantic cod (Gadus morhua L.) leucocytes and inhibits respiratory burst activity

Author:: Nils Vestvik; Anita Rønneseth; Cathrine A.K. Kalgraff; Hanne C. Winther-Larsen; Heidrun I. Wergeland; Gyri T. Haugland
Source:: Fish & shellfish immunology 2013 v.35 no.3 pp. 725-733
ISSN:: 1050-4648
Subject:: Francisella; Gadus morhua; antibiotics; antibodies; bacteria; cod (fish); evolution; flow cytometry; fluorescence; green fluorescent protein; kidneys; macrophages; monocytes; pathogenicity; pathogens; salmon; vaccines
Abstract:: ... Francisella noatunensis subsp. noatunensis, causing granulomatosis in cod, has been shown to reside within cod immune cells, mainly within monocytes and macrophages. In the present study, we analysed the ability of the bacterium to replicate within adherent cells isolated from head kidney by in vitro infection of leucocytes. Two different technical approaches for flow cytometry analyses were perfo ...
DOI:: 10.1016/j.fsi.2013.06.002
: https://doi.org/10.1016/j.fsi.2013.06.002

77. Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock

Author:: Ferwerda, Bart; Alonso, Santos; Banahan, Kathy; McCall, Matthew B.B.; Giamarellos-Bourboulis, Evangelos J.; Ramakers, Bart P.; Mouktaroudi, Maria; Fain, Pamela R.; Izagirre, Neskuts; Syafruddin, Din; Cristea, Tudor; Mockenhaupt, Frank P.; Troye-Blomberg, Marita; Kumpf, Oliver; Maiga, Boubacar; Dolo, Amagana; Doumbo, Ogobara; Sundaresan, Santhosh; Bedu-Addo, George; van Crevel, Reinout; Hamann, Lutz; Oh, Djin-Ye; Schumann, Ralf R.; Joosten, Leo A.B.; de la Rúa, Concepcion; Sauerwein, Robert; Drenth, Joost P.H.; Kullberg, Bart-Jan; van der Ven, André J.A.M.; Hill, Adrian V.; Pickkers, Peter; van der Meer, Jos W.M.; O'Neill, Luke A.J.; Netea, Mihai G.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.25 pp. 10272-10277
ISSN:: 0027-8424
Subject:: Homo sapiens; Toll-like receptor 2; Toll-like receptor 4; Toll-like receptor 9; alleles; antibiotics; cytokines; endotoxemia; evolution; homozygosity; humans; innate immunity; ligands; mutation; pathogenesis; pathogens; phenotype; septic shock; Eurasia
Abstract:: ... Adequate responses by our innate immune system toward invading pathogens were of vital importance for surviving infections, especially before the antibiotic era. Recently, a polymorphism in Mal (Ser180Leu, TIRAP rs8177374), an important adaptor protein downstream of the Toll-like receptor (TLR) 2 and 4 pathways, has been described to provide protection against a broad range of infectious pathogens ...
DOI:: 10.1073/pnas.0811273106
PubMed:: 19509334
PubMed Central:: PMC2700915
: https://doi.org/10.1073/pnas.0811273106

78. Gene networks regulating secondary metabolism in actinomycetes: Pleiotropic regulators

Author:: M. V. Rabyk; B. O. Ostash; V. O. Fedorenko
Source:: Cytology and genetics 2014 v.48 no.1 pp. 55-67
ISSN:: 0095-4527
Subject:: Actinomycetales; antibiotics; bacteria; biosynthesis; evolution; gene expression; genetic engineering; metabolic engineering; metabolome; morphogenesis; operon; regulator genes; screening
Abstract:: ... Current advances in the research and practical application of pleiotropic regulatory genes for antibiotic production in actinomycetes are reviewed. The basic regulatory mechanisms discovered in these bacteria are outlined. The examples described in the review show the importance of the manipulation of regulatory systems that affect the synthesis of antibiotics for the metabolic engineering of acti ...
DOI:: 10.3103/S0095452714010083
: https://doi.org/10.3103/S0095452714010083

79. Genetic parameters of resistance to pasteurellosis using novel response traits in rabbits

Author:: Merina Shrestha; Hervé Garreau; Elodie Balmisse; Bertrand Bed’hom; Ingrid David; Edouard Guitton; Emmanuelle Helloin; Guillaume Lenoir; Mickaël Maupin; Raphaël Robert; Frédéric Lantier; Mélanie Gunia
Source:: Genetics, selection, evolution 2020 v.52 no.1 pp. 34
ISSN:: 1297-9686
Subject:: Pasteurella multocida; abscess; antibiotics; average daily gain; bacteria; breeding programs; commercial farms; crossbreds; evolution; experimental design; genetic correlation; genetic resistance; genetic variation; heritability; laboratories; necropsy; pasteurellosis; phenotypic correlation; population; prevalence; rabbits; selection criteria; sires; weaning weight
Abstract:: ... BACKGROUND: Pasteurellosis (Pasteurella infection) is one of the most common bacterial infections in rabbits on commercial farms and in laboratory facilities. Curative treatments using antibiotics are only partly efficient, with frequent relapses. Breeding rabbits for improved genetic resistance to pasteurellosis is a sustainable alternative approach. In this study, we infected 964 crossbred rabbi ...
DOI:: 10.1186/s12711-020-00552-8
: https://doi.org/10.1186/s12711-020-00552-8

80. Genome Sequence and Characterization of Five Bacteriophages Infecting Streptomyces coelicolor and Streptomyces venezuelae: Alderaan, Coruscant, Dagobah, Endor1 and Endor2

Author:: Aël Hardy; Vikas Sharma; Larissa Kever; Julia Frunzke
Source:: Viruses 2020 v.12 no.10 pp. -
ISSN:: 1999-4915
Subject:: Siphoviridae; Streptomyces coelicolor; Streptomyces venezuelae; antibiotics; bacteria; bacteriophages; evolution; nucleotide sequences; predation; prediction; sequence analysis; transmission electron microscopy
Abstract:: ... Streptomyces are well-known antibiotic producers, also characterized by a complex morphological differentiation. Streptomyces, like all bacteria, are confronted with the constant threat of phage predation, which in turn shapes bacterial evolution. However, despite significant sequencing efforts recently, relatively few phages infecting Streptomyces have been characterized compared to other genera. ...
DOI:: 10.3390/v12101065
: https://doi.org/10.3390/v12101065

81. Genomic evolution of antibiotic resistance is contingent on genetic background following a long-term experiment with Escherichia coli

Author:: Kyle J. Card; Misty D. Thomas; Joseph L. Graves; Jeffrey E. Barrick; Richard E. Lenski
Source:: Proceedings of the National Academy of Sciences 2021 v.118 no.5 pp. -
ISSN:: 1091-6490
Subject:: Escherichia coli; antibiotic resistance; antibiotics; epistasis; evolution; genes; genetic background; genomics; long term experiments; phenotype; statistical analysis
Abstract:: ... Antibiotic resistance is a growing health concern. Efforts to control resistance would benefit from an improved ability to forecast when and how it will evolve. Epistatic interactions between mutations can promote divergent evolutionary trajectories, which complicates our ability to predict evolution. We recently showed that differences between genetic backgrounds can lead to idiosyncratic respons ...
Handle:: 10113/7344752
DOI:: 10.1073/pnas.2016886118
CHORUS:: 10.1073/pnas.2016886118
: https://doi.org/10.1073/pnas.2016886118

82. Helix insertion into bilayers and the evolution of membrane proteins

Author:: Renthal, Robert
Source:: Cellular and molecular life sciences 2010 v.67 no.7 pp. 1077-1088
ISSN:: 1420-682X
Subject:: Escherichia coli; antibiotics; evolution; genome; lipid bilayers; membrane proteins; peptides
Abstract:: ... Polytopic α-helical membrane proteins cannot spontaneously insert into lipid bilayers without assistance from polytopic α-helical membrane proteins that already reside in the membrane. This raises the question of how these proteins evolved. Our current knowledge of the insertion of α-helices into natural and model membranes is reviewed with the goal of gaining insight into the evolution of membran ...
DOI:: 10.1007/s00018-009-0234-9
PubMed:: 20039094
PubMed Central:: PMC2862650
: https://doi.org/10.1007/s00018-009-0234-9

83. High frequency and diversity of Vancomycin-resistant Enterococci (VRE) in Algerian healthcare settings

Author:: Hanane Zerrouki; Sid-Ahmed Rebiahi; Linda Hadjadj; Fatmi Ahlem; Yamina Elhabiri; Tahar Sedrati; Jean-Marc Rolain; Seydina M. Diene
Source:: Infection, genetics, and evolution 2021 v.92 pp. 104889
ISSN:: 1567-1348
Subject:: antibiotic resistance; antibiotics; evolution; genes; glycopeptides; health services; hospitals; infection; linezolid
Abstract:: ... The spread of vancomycin-resistant Enterococci (VRE) in Algerian hospital settings is poorly reported. Since the first report in 2006, few data have been available on the molecular mechanism of this resistance across the country. In this study, we investigate the frequency and antibiotic resistance mechanisms of Enterococci strains isolated from hospitalised patients in the Tlemcen university hosp ...
DOI:: 10.1016/j.meegid.2021.104889
: https://doi.org/10.1016/j.meegid.2021.104889

84. High occurrence of heavy metal tolerance genes in bacteria isolated from wastewater: A new concern?

Author:: Guilherme Sgobbi Zagui; Natália Columbaro Moreira; Danilo Vitorino Santos; Ana Lúcia Costa Darini; José L. Domingo; Susana Inés Segura-Muñoz; Leonardo Neves Andrade
Source:: Environmental research 2021 v.196 pp. 110352
ISSN:: 0013-9351
Subject:: Hafnia alvei; Serratia fonticola; antibiotic resistance; antibiotics; antimicrobial properties; arsenic; cadmium; cobalt; drug therapy; evolution; hospitals; human health; mercury(II) reductase; metal tolerance; research; sewage; silver; transporters; wastewater; wastewater treatment; zinc
Abstract:: ... Some heavy metals have antimicrobial activity and are considered as potential alternatives to traditional antibiotic therapy. However, heavy metal tolerance genes (HMTG) have been already detected and coding different tolerance mechanisms. Considering that certain metals are promising for antimicrobial therapy, evaluation of HMTG dissemination in bacteria from sewage is essential to understand the ...
DOI:: 10.1016/j.envres.2020.110352
: https://doi.org/10.1016/j.envres.2020.110352

85. Horizontal transfer of antibiotic resistance genes in clinical environments

Author:: Nicole A. Lerminiaux; Andrew D.S. Cameron
Source:: Canadian journal of microbiology 2019 v.65 no.1 pp. 34-44
ISSN:: 1480-3275
Subject:: antibiotic resistance; antibiotic resistance genes; antibiotics; bacteriophages; diagnostic techniques; evolution; horizontal gene transfer; hospitals; infectious diseases; inheritance (genetics); pathogens; plasmids
Abstract:: ... A global medical crisis is unfolding as antibiotics lose effectiveness against a growing number of bacterial pathogens. Horizontal gene transfer (HGT) contributes significantly to the rapid spread of resistance, yet the transmission dynamics of genes that confer antibiotic resistance are poorly understood. Multiple mechanisms of HGT liberate genes from normal vertical inheritance. Conjugation by p ...
DOI:: 10.1139/cjm-2018-0275
: https://doi.org/10.1139/cjm-2018-0275

86. Hyperstability and Substrate Promiscuity in Laboratory Resurrections of Precambrian β-Lactamases

Author:: Risso Valeria A.; Gavira Jose A.; Mejia-Carmona Diego F.; Gaucher Eric A.; Sanchez-Ruiz Jose M.
Source:: Journal of the American Chemical Society 2013 v.135 no.8 pp. 2899-2902
ISSN:: 1520-5126
Subject:: X-radiation; active sites; amino acids; antibiotics; beta-lactamase; denaturation; evolution; scaffolding proteins; temperature
Abstract:: ... We report a sequence reconstruction analysis targeting several Precambrian nodes in the evolution of class-A β-lactamases and the preparation and experimental characterization of their encoded proteins. Despite extensive sequence differences with the modern enzymes (∼100 amino acid differences), the proteins resurrected in the laboratory properly fold into the canonical lactamase structure. The en ...
DOI:: 10.1021/ja311630a
: https://doi.org/10.1021/ja311630a

87. Impact of bacterial persisters on their host

Author:: Ana L Moldoveanu; Julian A Rycroft; Sophie Helaine
Source:: Current opinion in microbiology 2021 v.59 pp. 65-71
ISSN:: 1369-5274
Subject:: antibiotic resistance; antibiotics; bacteria; biosynthesis; evolution; immune response; pathogen survival
Abstract:: ... The rise of antibiotic failure poses a severe threat to global health. There is growing concern that this failure is not solely driven by stable antibiotic resistance but also by a subpopulation of transiently non-growing, antibiotic tolerant bacteria. These ‘persisters’ have been proposed to seed relapsing infections, an important clinical outcome of treatment failure — although definitive eviden ...
DOI:: 10.1016/j.mib.2020.07.006
: https://doi.org/10.1016/j.mib.2020.07.006

88. An Indigenous Gut Bacterium, Enterococcus faecalis (Lactobacillales: Enterococcaceae), Increases Seed Consumption By Harpalus pensylvanicus (Coleoptera: Carabidae)

Author:: Schmid Ryan B.; Lehman R. Michael; Brözel Volker S.; Lundgren Jonathan G.
Source:: Florida entomologist 2014 v.97 no.2 pp. 575-584
ISSN:: 0015-4040
Subject:: Enterococcus faecalis; Harpalus; animals; antibiotics; biomass; diet; digestion; digestive enzymes; evolution; food webs; herbivores; insects; intestinal microorganisms; intestines; microsymbionts; seed predation; seeds; symbiosis
Abstract:: ... Microbial symbioses likely drive the evolution of diet within animals, yet these symbiotic relationships remain poorly understood for many organisms. The bacterial endosymbiont Enterococcus faecalis is found in the intestinal tract of the beetle Harpalus pensylvanicus (DeGeer) (Coleoptera: Carabidae) and is thought to contribute to the digestion of the insect's seed diet. We tested whether E. faec ...
DOI:: 10.1896/054.097.0232
: https://doi.org/10.1896/054.097.0232

89. Inhibiting the Evolution of Antibiotic Resistance

Author:: Mark N. Ragheb; Maureen K. Thomason; Chris Hsu; Patrick Nugent; John Gage; Ariana N. Samadpour; Ankunda Kariisa; Christopher N. Merrikh; Samuel I. Miller; David R. Sherman; Houra Merrikh
Source:: Molecular cell 2019 v.73 no.1 pp. 157-165.e5
ISSN:: 1097-2765
Subject:: DNA; DNA repair; DNA-directed RNA polymerase; alleles; antibiotic resistance; antibiotics; evolution; mutagenesis; new drugs; trimethoprim
Abstract:: ... Efforts to battle antimicrobial resistance (AMR) are generally focused on developing novel antibiotics. However, history shows that resistance arises regardless of the nature or potency of new drugs. Here, we propose and provide evidence for an alternate strategy to resolve this problem: inhibiting evolution. We determined that the DNA translocase Mfd is an “evolvability factor” that promotes muta ...
DOI:: 10.1016/j.molcel.2018.10.015
PubMed:: 30449724
PubMed Central:: PMC6320318
: https://doi.org/10.1016/j.molcel.2018.10.015

90. Inhibitory effects of aptamer targeted teicoplanin encapsulated PLGA nanoparticles for Staphylococcus aureus strains

Author:: Samet Ucak; Mert Sudagidan; Baris A. Borsa; Banu Mansuroglu; Veli C. Ozalp
Source:: World journal of microbiology & biotechnology 2020 v.36 no.5 pp. 69
ISSN:: 0959-3993
Subject:: Gram-positive bacteria; Staphylococcus epidermidis; antibiotic resistance; antibiotics; encapsulation; evolution; glycopeptides; methicillin-resistant Staphylococcus aureus; minimum inhibitory concentration; multiple drug resistance; nanoparticles; oligonucleotides; pathogens
Abstract:: ... Emergence of resistance to traditional antibiotic treatments necessitates alternative delivery systems. Teicoplanin is a glycopeptide antibiotic used in the treatments of serious infections caused by Gram-positive bacteria, including Methicillin Resistant Staphylococcus aureus (MRSA). One strategy to keep up with antibiotic resistance development is to limit dose and amount during treatments. Targ ...
DOI:: 10.1007/s11274-020-02845-y
: https://doi.org/10.1007/s11274-020-02845-y

91. Insertion Sequence IS26 Reorganizes Plasmids in Clinically Isolated Multidrug-Resistant Bacteria by Replicative Transposition

Author:: Susu He; Alison Burgess Hickman; Alessandro M. Varani; Patricia Siguier; Michael Chandler; John P. Dekker; Fred Dyda
Source:: mBio 2015 v.6 no.3 pp. e00762-15
ISSN:: 2150-7511
Subject:: Enterobacteriaceae; National Institutes of Health; antibiotic resistance; antibiotics; bacteria; beta-lactamase; evolution; genes; monitoring; multiple drug resistance; phenotype; plasmids; public health; replicon; transposition (genetics); transposons
Abstract:: ... Carbapenemase-producing Enterobacteriaceae (CPE), which are resistant to most or all known antibiotics, constitute a global threat to public health. Transposable elements are often associated with antibiotic resistance determinants, suggesting a role in the emergence of resistance. One insertion sequence, IS 26 , is frequently associated with resistance determinants, but its role remains unclear. ...
DOI:: 10.1128/mBio.00762-15
PubMed:: 26060276
PubMed Central:: PMC4471558
: https://doi.org/10.1128/mBio.00762-15

92. Insights on evolution of virulence and resistance from the whole-genome analysis of a predominant methicillin-resistant Staphylococcus aureus clone sequence type 239 in China

Author:: Hongbin Chen; Xi Yang; Qi Wang; Chunjiang Zhao; Henan Li; Wenqiang He; Xiaojuan Wang; Feifei Zhang; Zhanwei Wang; Minjun Chen; Baoli Zhu; Hui Wang
Source:: Chinese science bulletin 2014 v.59 no.11 pp. 1104-1112
ISSN:: 1001-6538
Subject:: Staphylococcus aureus; antibiotic resistance; antibiotics; beta-lactamase; blood; databases; evolution; genes; genomic islands; genomics; humans; immune system; transposons; virulence; China
Abstract:: ... Earlier, we reported that ST239 was the 15-year predominant methicillin-resistant Staphylococcus aureus (MRSA) clone in China. In this study, MRSA strain CN79 belonging to ST239 and isolated from blood was used to determine the whole genome sequence. Comparative genomics analysis was done between MRSA CN79 and 25 sequenced S. aureus in the NCBI GenBank database. A total of 2,734 protein-encoding g ...
DOI:: 10.1007/s11434-014-0149-1
: https://doi.org/10.1007/s11434-014-0149-1

93. Interpreting phenotypic antibiotic tolerance and persister cells as evolution via epigenetic inheritance

Author:: Troy Day
Source:: Molecular ecology 2016 v.25 no.8 pp. 1869-1882
ISSN:: 0962-1083
Subject:: RNA; antibiotic resistance; antibiotics; bacteria; epigenetics; evolution; gene expression; models; parents; phenotype; progeny
Abstract:: ... Epigenetic inheritance is the transmission of nongenetic material such as gene expression levels, RNA and other biomolecules from parents to offspring. There is a growing realization that such forms of inheritance can play an important role in evolution. Bacteria represent a prime example of epigenetic inheritance because a large array of cellular components is transmitted to offspring, in additio ...
DOI:: 10.1111/mec.13603
PubMed:: 26946044
PubMed Central:: PMC4846567
: https://doi.org/10.1111/mec.13603

94. Isolation, genome sequencing and functional analysis of two T7-like coliphages of avian pathogenic Escherichia coli

Author:: Mianmian Chen; Juntian Xu; Huochun Yao; Chengping Lu; Wei Zhang
Source:: Gene 2016 v.582 no.1 pp. 47-58
ISSN:: 0378-1119
Subject:: DNA; Enterobacteria phages; Erwinia; Escherichia coli; Kluyvera; Podoviridae; antibiotic resistance; antibiotics; bacteria; birds; coliphages; drug residues; electron microscopy; evolution; farmers; feces; financial economics; genes; genomics; high-throughput nucleotide sequencing; markets; poultry industry; proteins; sequence homology; China
Abstract:: ... Avian pathogenic Escherichia coli (APEC) causes colibacillosis, which results in significant economic losses to the poultry industry worldwide. Due to the drug residues and increased antibiotic resistance caused by antibiotic use, bacteriophages and other alternative therapeutic agents are expected to control APEC infection in poultry.Two APEC phages, named P483 and P694, were isolated from the fe ...
DOI:: 10.1016/j.gene.2016.01.049
: https://doi.org/10.1016/j.gene.2016.01.049

95. Local applications but global implications: Can pesticides drive microorganisms to develop antimicrobial resistance?

Author:: Balasubramanian Ramakrishnan; Kadiyala Venkateswarlu; Nambrattil Sethunathan; Mallavarapu Megharaj
Source:: Science of the total environment 2019 v.654 pp. 177-189
ISSN:: 0048-9697
Subject:: active ingredients; air; antibiotic resistance; antibiotics; chemotaxis; chromosomes; enzymes; evolution; genes; inheritance (genetics); leaves; microbiome; microorganisms; pesticide degradation; pesticides; physiological transport; plant tissues; plasmids; soil pollution; transporters
Abstract:: ... Pesticides are an important agricultural input, and the introduction of new active ingredients with increased efficiencies drives their higher production and consumption worldwide. Inappropriate application and storage of these chemicals often contaminate plant tissues, air, water, or soil environments. The presence of pesticides can lead to developing tolerance, resistance or persistence and even ...
DOI:: 10.1016/j.scitotenv.2018.11.041
: https://doi.org/10.1016/j.scitotenv.2018.11.041

96. Mechanisms and impact of genetic recombination in the evolution of Streptococcus pneumoniae

Author:: Chrispin Chaguza; Jennifer E. Cornick; Dean B. Everett
Source:: Computational and Structural Biotechnology Journal 2015 v.13 pp. 241-247
ISSN:: 2001-0370
Subject:: DNA; Streptococcus pneumoniae; adaptive immunity; antibiotics; bacteria; evolution; genetic recombination; genetic variation; genome; mutation; population genetics; therapeutics; vaccines
Abstract:: ... Streptococcus pneumoniae (the pneumococcus) is a highly recombinogenic bacterium responsible for a high burden of human disease globally. Genetic recombination, a process in which exogenous DNA is acquired and incorporated into its genome, is a key evolutionary mechanism employed by the pneumococcus to rapidly adapt to selective pressures. The rate at which the pneumococcus acquires genetic variat ...
DOI:: 10.1016/j.csbj.2015.03.007
PubMed:: 25904996
PubMed Central:: PMC4404416
: https://doi.org/10.1016/j.csbj.2015.03.007

97. Mechanisms of genome evolution of Streptococcus

Author:: Cheryl P. Andam; William P. Hanage
Source:: Infection, genetics, and evolution 2015 v.33 pp. 334-342
ISSN:: 1567-1348
Subject:: Streptococcus pneumoniae; antibiotic resistance; antibiotics; disease control; evolution; genes; genomics; horizontal gene transfer; hosts; humans; pathogenicity; pathogens; phenotypic variation; population dynamics; respiratory system; serotypes; vaccines
Abstract:: ... The genus Streptococcus contains 104 recognized species, many of which are associated with human or animal hosts. A globally prevalent human pathogen in this group is Streptococcus pneumoniae (the pneumococcus). While being a common resident of the upper respiratory tract, it is also a major cause of otitis media, pneumonia, bacteremia and meningitis, accounting for a high burden of morbidity and ...
DOI:: 10.1016/j.meegid.2014.11.007
PubMed:: 25461843
PubMed Central:: PMC4430445
: https://doi.org/10.1016/j.meegid.2014.11.007

98. Medical leech therapy in Ayurveda and biomedicine – A review

Author:: Sarvesh Kumar Singh; Kshipra Rajoria
Source:: Journal of Ayurveda and integrative medicine 2020 v.11 no.4 pp. 554-564
ISSN:: 0975-9476
Subject:: Ayurvedic medicine; antibiotics; evolution; flow; knowledge; paper; research; roots; surgery
Abstract:: ... Medicinal leech therapy or Hirudino therapy have roots back in ancient civilization. It was a prevalent form of therapy in various ailments. The novel Ayurveda text Sushruta Samhita devoted a complete chapter on hirudino therapy. In the early 20th century this therapy had a major setback due to origin and evolution of antibiotics. There was a discontinuity in the flow of knowledge about this thera ...
DOI:: 10.1016/j.jaim.2018.09.003
: https://doi.org/10.1016/j.jaim.2018.09.003

99. Metagenomic Analysis Revealing Antibiotic Resistance Genes (ARGs) and Their Genetic Compartments in the Tibetan Environment

Author:: Chen Baowei; Yuan Ke; Chen Xin; Yang Ying; Zhang Tong; Wang Yawei; Luan Tiangang; Zou Shichun; Li Xiangdong
Source:: Environmental Science & Technology 2016 v.50 no.13 pp. 6670-6679
ISSN:: 1520-5851
Subject:: animal wastes; antibiotic resistance; antibiotics; bacteria; bacterial communities; beta-lactams; chemical analysis; community structure; evolution; fluoroquinolones; genes; interspersed repetitive sequences; metagenomics; sediments; soil; China
Abstract:: ... Comprehensive profiles of antibiotic resistance genes (ARGs) and mobile genetic elements (MGEs) in a minimally impacted environment are essential to understanding the evolution and dissemination of modern antibiotic resistance. Chemical analyses of the samples collected from Tibet demonstrated that the region under investigation was almost devoid of anthropogenic antibiotics. The soils, animal was ...
DOI:: 10.1021/acs.est.6b00619
: https://doi.org/10.1021/acs.est.6b00619

100. Metagenomic Characterization of Resistance Genes in Deception Island and Their Association with Mobile Genetic Elements

Author:: Andrés Santos; Felipe Burgos; Jaime Martinez-Urtaza; Leticia Barrientos
Source:: Microorganisms 2022 v.10 no.7 pp. -
ISSN:: 2076-2607
Subject:: Pseudomonas; Psychrobacter; Staphylococcus; antibiotic resistance; antibiotics; evolution; metagenomics; soil; taxonomy; Antarctic region; Antarctica
Abstract:: ... Antibiotic resistance genes (ARGs) are undergoing a remarkably rapid geographic expansion in various ecosystems, including pristine environments such as Antarctica. The study of ARGs and environmental resistance genes (ERGs) mechanisms could provide a better understanding of their origin, evolution, and dissemination in these pristine environments. Here, we describe the diversity of ARGs and ERGs ...
DOI:: 10.3390/microorganisms10071432
: https://doi.org/10.3390/microorganisms10071432

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1. Staphylococcus aureus Sequences from Osteomyelitic Specimens of a Pathological Bone Collection from Pre-Antibiotic Times

2. ABCF ATPases Involved in Protein Synthesis, Ribosome Assembly and Antibiotic Resistance: Structural and Functional Diversification across the Tree of Life

3. Activation of the σᴱ-Dependent Stress Pathway by Conjugative TraR May Anticipate Conjugational Stress

4. Adaptive landscapes and protein evolution

5. Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance

6. Anti-biofilm, anti-hemolysis, and anti-virulence activities of black pepper, cananga, myrrh oils, and nerolidol against Staphylococcus aureus

7. Antibacterial Activities of Ramalin, Usnic Acid and its Three Derivatives Isolated from the Antarctic Lichen Ramalina terebrata

8. Antibiotic Adjuvants: Rescuing Antibiotics from Resistance

9. Antibiotic resistome in the livestock and aquaculture industries: Status and solutions

10. Antibiotic-Induced Replication Stress Triggers Bacterial Competence by Increasing Gene Dosage near the Origin

11. Antibiotics and evolution: food for thought

12. Antimicrobial interactions: mechanisms and implications for drug discovery and resistance evolution

13. Antimicrobial natural products: an update on future antibiotic drug candidates

14. Antimicrobial peptides: natural templates for synthetic membrane-active compounds

15. Application of biosolids drives the diversity of antibiotic resistance genes in soil and lettuce at harvest

16. Bacterial resistance to cationic antimicrobial peptides

17. Biodegradable Antimicrobial Food Packaging: Trends and Perspectives

18. Bioinformatics tools and databases for whole genome sequence analysis of Mycobacterium tuberculosis

19. Candida albicans, a reservoir of Listeria monocytogenes?

20. Changes in the Oxidative Stress Status of Dogs Affected by Acute Enteropathies

21. Changing epidemiology of pediatric Streptococcus pneumoniae isolates before vaccine introduction in Casablanca (Morocco)

22. Characterization and genome analysis of the temperate bacteriophage φSAJS1 from Streptomyces avermitilis

23. Characterization of L1 retrotransposition with high-throughput dual-luciferase assays

24. Class 1 integrons in environmental and clinical isolates of Pseudomonas aeruginosa

25. Co-Evolutionary Dynamics of the Bacteria Vibrio sp. CV1 and Phages V1G, V1P1, and V1P2: Implications for Phage Therapy

26. Cold-adapted bacteria from a coastal area of the Ross Sea (Terra Nova Bay, Antarctica): linking microbial ecology to biotechnology

27. Collateral sensitivity of antibiotic-resistant microbes

28. Commensal bacteria play a role in mating preference of Drosophila melanogaster

29. Comparative analysis of essential genes and nonessential genes in Escherichia coli K12

30. Comparative genome analysis of IncHI2 VIM-1 carbapenemase-encoding plasmids of Escherichia coli and Salmonella enterica isolated from a livestock farm in Germany

31. Comparative morpho-physiology of the metapleural glands of two Atta leaf-cutting ant queens nesting in clayish and organic soils

32. Comparative proteomics analyses of Acinetobacter baumannii strains ATCC 17978 and AB5075 reveal the differential role of type II secretion system secretomes in lung colonization and ciprofloxacin resistance

33. Comparing the selective and co-selective effects of different antimicrobials in bacterial communities

34. Competence in Streptococcus pneumoniae Is Regulated by the Rate of Ribosomal Decoding Errors

35. Complete genome sequence and epigenetic profile of Bacillus velezensis UCMB5140 used for plant and crop protection in comparison with other plant-associated Bacillus strains

36. The Complexity of the Holobiont in the Red Sea Coral Euphyllia paradivisa under Heat Stress

37. Composition of nutrient media and temperature of cultivation imposes effect on the content of secondary metabolites of Nocardiopsis sp. isolated from a Siberian Cave

38. Confronting herbicide resistance with cooperative management

39. Could transformation mechanisms of acetylase-harboring pMdT1 plasmid be evaluated through proteomic tools in Escherichia coli?

40. Critical knowledge gaps and research needs related to the environmental dimensions of antibiotic resistance

41. Culturing Ancient Bacteria Carrying Resistance Genes from Permafrost and Comparative Genomics with Modern Isolates

42. Cysteine-stabilized αβ defensins: From a common fold to antibacterial activity

43. Darwinian Evolution Can Follow Only Very Few Mutational Paths to Fitter Proteins

44. Detection of Extended-Spectrum β-Lactamase-Producing Escherichia coli Using Infrared Microscopy and Machine-Learning Algorithms

45. Development of a Convergent Enantioselective Synthetic Route to (−)-Myrocin G

46. Development of a poly(ether urethane) system for the controlled release of two novel anti-biofilm agents based on gallium or zinc and its efficacy to prevent bacterial biofilm formation

47. Differences in recipient ability of uropathogenic Escherichia coli strains in relation with their pathogenic potential

48. Disk prediffusion is a reliable method for testing colistin susceptibility in porcine E. coli strains

49. Dissecting the roles of conductive materials in attenuating antibiotic resistance genes: Evolution of physiological features and bacterial community

50. Distribution and transfer of antibiotic resistance genes in different soil–plant systems

51. Distribution of antibiotic resistance and virulence factors among the bacteria isolated from diseased Etroplus suratensis

52. Diversity and variation in antimicrobial susceptibility patterns over time in Mycoplasma agalactiae isolates collected from sheep and goats in France

53. Does Soil Contribute to the Human Gut Microbiome?

54. Domain dissection and characterization of the aminoglycoside resistance enzyme ANT(3″)-Ii/AAC(6′)-IId from Serratia marcescens

55. Drug efflux pump deficiency and drug target resistance masking in growing bacteria

56. E622, a Miniature, Virulence-Associated Mobile Element

57. Effects of various antibiotics on aerobic nitrogen removal and antibiotic degradation performance: Mechanism, degradation pathways, and microbial community evolution

58. Emerging evolutionary paradigms in antibiotic discovery

59. Energy- and cost-effective non-sterilized fermentation of 2,3-butanediol by an engineered Klebsiella pneumoniae OU7 with an anti-microbial contamination system

60. Engineered bacteriophage targeting gene networks as adjuvants for antibiotic therapy

61. Enhancing recovery performance of the toluene-removing biofilter after the short/long interference-shutdown period

62. Environmentally friendly approaches to genetic engineering

63. Epidemiology of asexuality induced by the endosymbiotic Wolbachia across phytophagous wasp species: host plant specialization matters

64. Evolution of Antibacterial Drug Screening Methods: Current Prospects for Mycobacteria

65. The Evolution of Cefotaximase Activity in the TEM β-Lactamase

66. Evolution of Resistance to Quorum-Sensing Inhibitors

67. Evolution of extensively drug-resistant Mycobacterium tuberculosis from a susceptible ancestor in a single patient

68. Evolution of pathogens in a man-made world

69. Evolution of structural fitness and multifunctional aspects of mycobacterial RND family transporters

70. Evolution of surviving Streptoccocus pyogenes from pharyngotonsillitis patients submit to multiple cycles of antimicrobial photodynamic therapy