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You searched for: Subject antineoplastic activity Remove constraint Subject: antineoplastic activity Subject DNA Remove constraint Subject: DNA Subject term antineoplastic activity Remove constraint Subject term: antineoplastic activity Subject term urinary bladder neoplasms Remove constraint Subject term: urinary bladder neoplasms Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
3 Search Results
1. Withaferin a Triggers Apoptosis and DNA Damage in Bladder Cancer J82 Cells through Oxidative Stress
- Tsu-Ming Chien; Kuang-Han Wu; Ya-Ting Chuang; Yun-Chiao Yeh; Hui-Ru Wang; Bi-Wen Yeh; Chia-Hung Yen; Tzu-Jung Yu; Wen-Jeng Wu; Hsueh-Wei Chang
- Antioxidants 2021 v.10 no.7 pp. -
- DNA; DNA damage; Withania somnifera; acetylcysteine; antineoplastic activity; apoptosis; bioactive compounds; caspases; catalase; cell cycle; flow cytometry; glutathione-disulfide reductase; heme oxygenase (biliverdin-producing); membrane potential; mitochondria; mitochondrial membrane; oxidative stress; quinones; reactive oxygen species; superoxide dismutase; thioredoxins; urinary bladder neoplasms
- ... Withaferin A (WFA), the Indian ginseng bioactive compound, exhibits an antiproliferation effect on several kinds of cancer, but it was rarely reported in bladder cancer cells. This study aims to assess the anticancer effect and mechanism of WFA in bladder cancer cells. WFA shows antiproliferation to bladder cancer J82 cells based on the finding of the MTS assay. WFA disturbs cell cycle progression ...
- Bapurao Surnar; Nagesh Kolishetti; Uttara Basu; Anis Ahmad; Erik Goka; Brian Marples; David Kolb; Marc E. Lippman; Shanta Dhar
- Biochemistry 2018 v.57 no.46 pp. 6500-6513
- DNA; DNA damage; adverse effects; antineoplastic activity; aspirin; cisplatin; drug therapy; in vitro studies; models; nausea; nephrotoxicity; neurotoxicity; patients; urinary bladder neoplasms
- ... Cisplatin is a major chemotherapeutic that continues to have a significant impact in the treatment of more than 50% of all cancers. Since its Food and Drug Administration approval in 1978 for the treatment of advanced ovarian and bladder cancer, this chemotherapeutic has made significant strides and its application has been extended to a large variety of other cancers. However, the vast majority o ...
3. Genotoxicity and cytotoxicity of oxindole alkaloids from Uncaria tomentosa (cat's claw): Chemotype relevance
- Samuel Kaiser; Ânderson Ramos Carvalho; Vanessa Pittol; Fabrícia Dietrich; Fabiana Manica; Michel Mansur Machado; Luis Flávio Souza de Oliveira; Ana Maria Oliveira Battastini; George González Ortega
- Journal of ethnopharmacology 2016 v.189 pp. 90-98
- DNA; Uncaria tomentosa; alkaloids; antineoplastic activity; bark; chemotypes; claws; cytotoxicity; freeze drying; genotoxicity; glioblastoma; human cell lines; ion exchange; isomerization; leaves; leukocytes; mutagens; neoplasm cells; rain forests; traditional medicine; urinary bladder neoplasms; vines
- ... Uncaria tomentosa (Willdenow ex Roemer & Schultes) DC. (Rubiaceae) or cat's claw is a climber vine from the South American rainforest used in folk medicine for cancer treatment. Its antitumor activity has been mostly ascribed to pentacyclic oxindole alkaloids (POA) from stem bark and leaves while the activity of tetracyclic oxindole alkaloids (TOA) remains unknown. In recent times, the occurrence ...