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You searched for: Subject antineoplastic activity Remove constraint Subject: antineoplastic activity Subject antioxidant activity Remove constraint Subject: antioxidant activity Subject antineoplastic agents Remove constraint Subject: antineoplastic agents
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1. Anticancer effects of fraction isolated from fruiting bodies of Chaga medicinal mushroom, Inonotus obliquus (Pers.:Fr.) Pilat (Aphyllophoromycetideae): In vitro studies

Author:
Lemieszek, Marta Kinga; Langner, Ewa; Kaczor, Jozef; Kandefer-Szerszen, Martyna; Sanecka, Bozena; Mazurkiewicz, Witold; Rzeski, Wojciech
Source:
International journal of medicinal mushrooms 2011 v.13 no.2 pp. 131-143
ISSN:
1521-9437
Subject:
Inonotus obliquus; adenocarcinoma; animal models; antineoplastic activity; antineoplastic agents; antioxidant activity; aorta; astrocytes; cattle; cell culture; cell movement; cell proliferation; colon; cytotoxicity; death; digestive system diseases; endothelial cells; enzyme-linked immunosorbent assay; fibroblasts; fruiting bodies; health promotion; heart; hepatocytes; humans; in vitro studies; liver; lung neoplasms; medicinal fungi; mice; mushrooms; neoplasm cells; neurons; oligodendroglia; rats; staining; toxicity testing; traditional medicine; viability; Poland; Russia
Abstract:
... The medicinal mushroom Chaga, Inonotus obliquus (Pers.:Fr.) Pilat (Hymenochaetaceae), has been used in folk medicine in Russia, Poland, and most of the Baltic countries, as a cleansing and disinfecting measure, and as decoctions for stomach diseases, intestinal worms, liver and heart ailments, and cancer treatment. Many reports have been published concerning the health promoting functions of this ...
DOI:
10.1615/IntJMedMushr.v13.i2.50

2. Antioxidant and cytotoxic activity of polyphenolic compounds isolated from the leaves of Leucenia leucocephala

Author:
Haggag, Eman G.; Kamal, Amel M.; Abdelhady, Mohamed I.S.; El-Sayed, Mortada M.; El-Wakil, Eman A.; Abd-El-hamed, Sayed S.
Source:
Pharmaceutical biology 2011 v.49 no.11 pp. 1103-1113
ISSN:
1388-0209
Subject:
Fabaceae; active ingredients; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apigenin; chemical structure; chromatography; cytotoxicity; glycosides; health services; hepatoma; inhibitory concentration 50; leaf extracts; leaves; luteolin; methanol; myricetin; nuclear magnetic resonance spectroscopy; polyphenols; Egypt
Abstract:
... Context: Cancer is a serious clinical problem to the health care system. Anticancer drugs have been extracted from plants containing phenolic compounds. Leucenia species (Fabaceae) contain a variety of bioactive components of numerous biological and pharmacological properties. Objective: This study explored the constitutive polyphenols of Leucenia leucocephala Lam. growing in Egypt and evaluated t ...
DOI:
10.3109/13880209.2011.568623

3. Antioxidant, antimicrobial and anticancer activity of the lichens Cladonia furcata, Lecanora atra and Lecanora muralis

Author:
Branislav R Ranković; Marijana M Kosanić; Tatjana P Stanojković
Source:
BMC complementary and alternative medicine 2011 v.11 no.1 pp. 97
ISSN:
1472-6882
Subject:
Cladonia; Lecanora; acetone; alternative medicine; anti-infective agents; antimicrobial properties; antineoplastic activity; antineoplastic agents; antioxidant activity; bacteria; colorectal neoplasms; flavonoids; free radical scavengers; fungi; humans; inhibitory concentration 50; lichens; melanoma; minimum inhibitory concentration; phenolic compounds; plant diseases and disorders
Abstract:
... BACKGROUND: The aim of this study is to investigate in vitro antioxidant, antimicrobial and anticancer activity of the acetone extracts of the lichens Cladonia furcata, Lecanora atra and Lecanora muralis. METHODS: Antioxidant activity was evaluated by five separate methods: free radical scavenging, superoxide anion radical scavenging, reducing power, determination of total phenolic compounds and d ...
DOI:
10.1186/1472-6882-11-97
PubMed:
22013953
PubMed Central:
PMC3224239

4. Characterization, antioxidant and antitumor activities of polysaccharides from Salvia miltiorrhiza Bunge

Author:
Yuan-yuan Jiang; Long Wang; Li Zhang; Tao Wang; Lin Yu; Chun-bang Ding; Rui-wu Yang; Xiao-li Wang; Yong-hong Zhou
Source:
International journal of biological macromolecules 2014 v.70 pp. 92-99
ISSN:
0141-8130
Subject:
2,2-diphenyl-1-picrylhydrazyl; Salvia miltiorrhiza; antineoplastic activity; antineoplastic agents; antioxidant activity; breast neoplasms; free radical scavengers; humans; in vitro studies; neoplasm cells; polysaccharides; response surface methodology; temperature; ultrasonic treatment; ultrasonics
Abstract:
... Polysaccharides were extracted from Salvia miltiorrhiza Bunge using response surface methodology (RSM) with ultrasonication. A Box–Behnken design was used to optimize the extraction parameters to maximize the polysaccharide extraction yield. The polysaccharide SMP-U1 was isolated and characterized; then the antioxidant and antiproliferation activities were evaluated in vitro. The modified optimal ...
DOI:
10.1016/j.ijbiomac.2014.06.036

5. Cladonia lichens and their major metabolites as possible natural antioxidant, antimicrobial and anticancer agents

Author:
Marijana Kosanić; Branislav Ranković; Tatjana Stanojković; Aleksandar Rančić; Nedeljko Manojlović
Source:
Lebensmittel-Wissenschaft + Technologie 2014 v.59 no.1 pp. 518-525
ISSN:
0023-6438
Subject:
Cladonia rangiferina; acetone; anti-infective properties; antineoplastic activity; antineoplastic agents; antioxidant activity; colorectal neoplasms; free radical scavengers; inhibitory concentration 50; lichens; melanoma; metabolites; minimum inhibitory concentration; pyrocatechol; rutin; superoxide anion
Abstract:
... The aim of this study is to investigate in vitro antioxidant, antimicrobial, and anticancer activities of the acetone extracts of the lichens Cladonia furcata, Cladonia pyxidata and Cladonia rangiferina and their atranorin and fumarprotocetraric acid constituents. Antioxidant activity was evaluated by free radical scavenging, superoxide anion radical scavenging, reducing power, and determination o ...
DOI:
10.1016/j.lwt.2014.04.047

6. Cytotoxic and antioxidant properties of active principals isolated from water hyacinth against four cancer cells lines

Author:
Ahmed M Aboul-Enein; Sanaa MM Shanab; Emad A Shalaby; Malak M Zahran; David A Lightfoot; Hany A El-Shemy
Source:
BMC complementary and alternative medicine 2014 v.14 no.1 pp. 397
ISSN:
1472-6882
Subject:
2,2-diphenyl-1-picrylhydrazyl; DNA fragmentation; Eichhornia crassipes; air drying; alkaloids; alternative medicine; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; cleaning; cytotoxicity; drainage channels; ethyl acetate; hexane; human cell lines; macrophytes; magnetism; methanol; neoplasm cells; neoplasms; river deltas; silica gel; spectroscopy; terpenoids; Egypt
Abstract:
... BACKGROUND: Eichhornia crassipes (Mart) solms is an invasive macrophyte causing serious problems to the network of irrigation and drainage canals in the Nile Delta region. The present study aim to evaluate the potential anticancer and antioxidant activities of Eichhornia crassipes crude extract and its pure compounds. METHODS: The macrophyte was collected from El-Zomor canal, River Nile (Egypt), c ...
DOI:
10.1186/1472-6882-14-397
PubMed:
25315352
PubMed Central:
PMC4213547

7. Fruit-derived phenolic compounds and pancreatic cancer: Perspectives from Australian native fruits

Author:
Q.V. Vuong; S. Hirun; P.A. Phillips; T.L.K. Chuen; M.C. Bowyer; C.D. Goldsmith; C.J. Scarlett
Source:
Journal of ethnopharmacology 2014 v.152 no.2 pp. 227-242
ISSN:
0378-8741
Subject:
antineoplastic activity; antineoplastic agents; antioxidant activity; bioactive compounds; carcinogenesis; databases; flora; foods; fruits; mechanism of action; pancreatic neoplasms; polyphenols; therapeutics; traditional medicine
Abstract:
... Pancreatic cancer is a devastating cancer that presents late, is rapidly progressive and has current therapeutics with only limited efficacy. Bioactive compounds are ubiquitously present in fruits and numerous studies in vitro are addressing the activity of these compounds against pancreatic cancer, thus studies of specific bioactive compounds could lead to new anti-pancreatic cancer strategies. A ...
DOI:
10.1016/j.jep.2013.12.023

8. Intracellular Antioxidants Dissolve Man-Made Antioxidant Nanoparticles: Using Redox Vulnerability of Nanoceria to Develop a Responsive Drug Delivery System

Author:
Muhammad Faheem; Wang Aifei; Qi Wenxiu; Zhang Shixing; Zhu Guangshan
Source:
ACS Applied Materials & Interfaces 2014 v.6 no.21 pp. 19424-19433
ISSN:
1944-8252
Subject:
antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; ascorbic acid; biotransformation; body fluids; ceric oxide; drug delivery systems; glutathione; nanoparticles; porous media; silica
Abstract:
... Regeneratable antioxidant property of nanoceria has widely been explored to minimize the deleterious influences of reactive oxygen species. Limited information is, however, available regarding the biological interactions and subsequent fate of nanoceria in body fluids. This study demonstrates a surprising dissolution of stable and ultrasmall (4 nm) cerium oxide nanoparticles (CeO₂ NPs) in response ...
DOI:
10.1021/am5055367

9. Structural characterization and bioactivity of released exopolysaccharides from Lactobacillus plantarum 70810

Author:
Kun Wang; Wei Li; Xin Rui; Xiaohong Chen; Mei Jiang; Mingsheng Dong
Source:
International journal of biological macromolecules 2014 v.67 pp. 71-78
ISSN:
0141-8130
Subject:
2,2-diphenyl-1-picrylhydrazyl; Lactobacillus plantarum; anion exchange; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; ethanol; exopolysaccharides; free radicals; galactose; gel chromatography; glucose; in vitro studies; mannose; methylation; molecular weight; nuclear magnetic resonance spectroscopy
Abstract:
... Two released exopolysaccharides (r-EPS1 and r-EPS2) were isolated from the culture supernatant of Lactobacillus plantarum 70810 by ethanol precipitation, anion exchange and gel filtration chromatography and characterization of the structures were conducted. The r-EPS1 and r-EPS2 were homogenous polysaccharides with average molecular weights of, respectively, 204.6 and 202.8kDa, and composed of glu ...
DOI:
10.1016/j.ijbiomac.2014.02.056

10. Antioxidant and antitumor activities in vitro of polysaccharides from E. sipunculoides

Author:
Rongjun He; Yuejun Zhao; Ruina Zhao; Peilong Sun
Source:
International journal of biological macromolecules 2015 v.78 pp. 56-61
ISSN:
0141-8130
Subject:
antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; hydrolysis; papain; polysaccharides; sugar content
Abstract:
... Three polysaccharides (SAP30, SAP60 and SAP80) were separated from the body of Edwardsia sipunculoides by tissue homogenate and papain hydrolysis. Total soluble sugar contents, monosaccharide compositions, antioxidant and antitumor activities in vitro of those polysaccharides were investigated, respectively. Results showed that the total soluble sugar contents of SAP composed of Man, GlcN, Rha, Ga ...
DOI:
10.1016/j.ijbiomac.2015.03.030

11. In vitro antioxidant potential of Shemamruthaa (a herbal formulation) and its anticancer activity in the MCF-7 cell line

Author:
Nandhakumar Elumalai; Purushothaman Ayyakkannu; Shanthi Palanivelu; Sachdanandam Panchanadham
Source:
RSC advances 2015 v.5 no.30 pp. 23125-23133
ISSN:
2046-2069
Subject:
2,2-diphenyl-1-picrylhydrazyl; Hibiscus rosa-sinensis; Phyllanthus emblica; antineoplastic activity; antineoplastic agents; antioxidant activity; breast neoplasms; flavonoids; free radical scavengers; honey; human cell lines; hydroxyl radicals; inhibitory concentration 50; lipid peroxidation; nitric oxide
Abstract:
... The current study investigates the free radical scavenging activities of Shemamruthaa (Hibiscus rosa sinensis, Emblica officinalis and honey in definite ratio) and its anticancer activity in the breast cancer (MCF-7) cell line ex vivo. The free radical scavenging activities of the Shemamruthaa extracts viz. 1,1-diphenyl-2-picrylhydrazyl (DPPH), nitric oxide, superoxide and hydroxyl radical scaveng ...
DOI:
10.1039/c4ra12346h

12. Isolation and antitumor efficacy evaluation of a polysaccharide from Nostoc commune Vauch.

Author:
Min Guo; Guo-Bin Ding; Songjia Guo; Zhuoyu Li; Liangqi Zhao; Ke Li; Xiangrong Guo
Source:
Food & function 2015 v.6 no.9 pp. 3035-3044
ISSN:
2042-650X
Subject:
Nostoc commune; antineoplastic activity; antineoplastic agents; antioxidant activity; apoptosis; drug therapy; endoplasmic reticulum stress; mechanism of action; neoplasms; polysaccharides; signal transduction
Abstract:
... Nostoc commune Vauch. has been traditionally used as a healthy food and medicine for centuries especially in China. It has been demonstrated that the polysaccharides isolated from Nostoc commune Vauch. exhibit strong antimicrobial and antioxidant activities. However, little is known about their anticancer activities and the underlying mechanisms of action. Herein, we report the isolation of a poly ...
DOI:
10.1039/c5fo00471c

13. Kaempferol mediated synthesis of gold nanoparticles and their cytotoxic effects on MCF-7 cancer cell line

Author:
Bhuvanasree Srinivas Raghavan; Sindhu Kondath; Rajaram Anantanarayanan; Rama Rajaram
Source:
Process Biochemistry 2015 v.50 pp. 1966-1976
ISSN:
1359-5113
Subject:
2,2-diphenyl-1-picrylhydrazyl; ambient temperature; angiogenesis; antineoplastic activity; antineoplastic agents; antioxidant activity; apoptosis; breast neoplasms; chorioallantoic membrane; cytotoxicity; ethidium; hemolysis; kaempferol; nanogold; nanoparticles; neoplasm cells; scanning electron microscopy; staining; therapeutics; transmission electron microscopy; vascular endothelial growth factors; viability
Abstract:
... Kaempferol (3,5,7,4′tetrahydroxyflavone), a flavonol present in a variety of plant sources, has been used for the formation of gold nanoparticles (k-AuNPs) and these particles have been evaluated for their anti-cancer properties. These nanoparticles have been formed at room temperature (RT) without any other stabilizing agents and are studied for the first time. The size of k-AuNPs is observed to ...
DOI:
10.1016/j.procbio.2015.08.003

14. Selenium compounds as therapeutic agents in cancer

Author:
Aristi P. Fernandes; Valentina Gandin
Source:
BBA - General Subjects 2015 v.1850 pp. 1642-1660
ISSN:
0304-4165
Subject:
antineoplastic activity; antineoplastic agents; antioxidant activity; biochemical pathways; drug therapy; nanoparticles; neoplasm cells; neoplasms; oxidative stress; reactive oxygen species; selenium; tissues
Abstract:
... With cancer cells encompassing consistently higher production of reactive oxygen species (ROS) and with an induced antioxidant defense to counteract the increased basal ROS production, tumors have a limited reserve capacity resulting in an increased vulnerability of some cancer cells to ROS. Based on this, oxidative stress has been recognized as a tumor-specific target for the rational design of n ...
DOI:
10.1016/j.bbagen.2014.10.008

15. Design, synthesis, characterization of some new 1,2,3-triazolyl chalcone derivatives as potential anti-microbial, anti-oxidant and anti-cancer agents via a Claisen–Schmidt reaction approach

Author:
Manjunatha Bhat; Nagaraja G. K.; Divyaraj P.; Harikrishna N.; Sreedhara Ranganath Pai K.; Subhankar Biswas; Peethamber S. K.
Source:
RSC advances 2016 v.6 no.102 pp. 99794-99808
ISSN:
2046-2069
Subject:
antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; breast neoplasms; cell lines; chalcone; condensation reactions; ethanol; neoplasm cells; nuclear magnetic resonance spectroscopy; sodium hydroxide; spectral analysis
Abstract:
... The synthesis of a new series of (2E)-1-{1-[2,3-dichloro-6-methyl-5-(trifluoromethyl)phenyl]-5-methyl-1H-1,2,3-triazol-4-yl}-3-aryl prop-2-en-1-one (5a–k) and (2E)-1-{1-[2,3-dichloro-6-methyl-5-(trifluoromethyl)phenyl]-5-methyl-1H-1,2,3-triazol-4-yl}-3-(1,3-diaryl-1H-pyrazol-4-yl)prop-2-en-1-one (6a–e) were carried out via a Claisen–Schmidt condensation of 1-{1-[2,3-dichloro-6-methyl-5-(trifluorom ...
DOI:
10.1039/c6ra22705h

16. Exploratory studies of the potential anti-cancer effects of creatine

Author:
P. L. Campos-Ferraz; B. Gualano; W. das Neves; I. T. Andrade; I. Hangai; R. T. S. Pereira; R. N. Bezerra; R. Deminice; M. Seelaender; A. H. Lancha
Source:
Amino acids 2016 v.48 no.8 pp. 1993-2001
ISSN:
0939-4451
Subject:
acidosis; antineoplastic activity; antineoplastic agents; antioxidant activity; bicarbonates; blood; body weight; creatine; creatine kinase; inflammation; interleukin-10; interleukin-6; males; mechanism of action; neoplasm cells; neoplasms; oxidative stress; rats; survival rate; tumor necrosis factor-alpha
Abstract:
... Two experiments were performed, in which male Wistar Walker 256 tumor-bearing rats were inoculated with 4 × 10⁷ tumor cells subcutaneously and received either creatine (300 mg/kg body weight/day; CR) or placebo (water; PL) supplementation via intragastric gavage. In experiment 1, 50 rats were given PL (n = 22) or CR (n = 22) and a non-supplemented, non-inoculated group served as control CT (n = 6) ...
DOI:
10.1007/s00726-016-2180-9

17. In vitro evaluation of antioxidant and cytotoxic activities of lignin fractions extracted from Acacia nilotica

Author:
Anand Barapatre; Avtar Singh Meena; Sowmya Mekala; Amitava Das; Harit Jha
Source:
International journal of biological macromolecules 2016 v.86 pp. 443-453
ISSN:
0141-8130
Subject:
2,2-diphenyl-1-picrylhydrazyl; Vachellia nilotica; antineoplastic activity; antineoplastic agents; antioxidant activity; breast neoplasms; cytotoxicity; free radical scavengers; humans; hydrophobicity; in vitro studies; inhibitory concentration 50; iron; lignin; linoleic acid; nitric oxide; solvents; superoxide anion; wood
Abstract:
... Lignin is one of the most important phytomacromolecule with diverse therapeutic properties such as anticancer, antimicrobial, anti-inflammatory and immune-stimulatory. The present study was carried out to evaluate the in vitro antioxidant, free radical scavenging and anti-proliferative/cytotoxic activities of eleven different lignin fractions, extracted from the wood of Acacia nilotica by pressuri ...
DOI:
10.1016/j.ijbiomac.2016.01.109

18. Synthesis and cytotoxicity evaluation of 3-amino-2-hydroxypropoxyisoflavone derivatives

Author:
Jing-Jing TANG; Xiao-Ting GENG; Ya-Jing WANG; Tian-Yu ZHENG; Jin-Rong LU; Rong HU
Source:
Chinese journal of natural medicines 2016 v.14 no.6 pp. 462-472
ISSN:
1875-5364
Subject:
Oriental traditional medicine; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; chemoprevention; cytotoxicity; enzymes; gene expression regulation; human cell lines; humans; isoflavones; neoplasm cells; neoplasms; oxidative stress; protein content
Abstract:
... Soy isoflavones exert a wide variety of biological activities, such as antioxidant, anti-inflammatory and anti-cancer properties. Nuclear factor erythroid 2-related factor 2 (Nrf2), a bZip transcription factor, plays a key role in soy isoflavones induced protection against oxidative stress and cancer. To obtain more effective isofavones, a series of 7,4′-bis-(3-amino-2-hydroxypropoxy), 7 or 4′-(3- ...
DOI:
10.1016/S1875-5364(16)30044-9

19. Antioxidant, cytotoxic and antineoplastic effects of Carissa carandas Linn. leaves

Author:
Marina Khatun; M. Rowshanul Habib; M. Ahasanur Rabbi; Ruhul Amin; M. Farhadul Islam; M. Nurujjaman; M. Rezaul Karim; M. Habibur Rahman
Source:
Experimental and toxicologic pathology 2017 v.69 no.7 pp. 469-476
ISSN:
0940-2993
Subject:
2,2-diphenyl-1-picrylhydrazyl; 4',6-diamidino-2-phenylindole; Carissa carandas; adenocarcinoma; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; ascites; ascorbic acid; cytotoxicity; dose response; erythrocytes; fluorescence microscopy; gas chromatography-mass spectrometry; gene expression; hematologic tests; hemoglobin; inhibitory concentration 50; leaf extracts; leaves; leukocytes; longevity; medicinal plants; methanol; mice; polyphenols; traditional medicine; viability; Bangladesh
Abstract:
... For scientific clarification of some traditional uses, this study was designed to explore the antioxidant, cytotoxic and antineoplastic properties of leaf extract of Carissa carandas Linn., a traditional medicinal plant of Bangladesh. The methanol extract of Carissa carandas leaves (MELC) was applied on DPPH and ABTS experiments to determine its antioxidant activity. In vitro the cytotoxic effect ...
DOI:
10.1016/j.etp.2017.03.008

20. Biological activities and chemical compositions of slime tracks and crude exopolysaccharides isolated from plasmodia of Physarum polycephalum and Physarella oblonga

Author:
Tuyen T.M Huynh; Trung V. Phung; Steven L. Stephenson; Hanh T.M Tran
Source:
BMC biotechnology 2017 v.17 no.1 pp. 76
ISSN:
1472-6750
Subject:
Candida albicans; Physarum polycephalum; antifungal agents; antimicrobial properties; antineoplastic activity; antineoplastic agents; antioxidant activity; chemical analysis; chemical composition; common names; cytotoxicity; exopolysaccharides; fungi; galactose; glucose; inhibitory concentration 50; minimum inhibitory concentration; neoplasm cells; neoplasms; proteins; rhamnose; sulfates
Abstract:
... BACKGROUND: The myxomycetes derive their common name (slime molds) from the multinucleate trophic stage (plasmodium) in the life cycle, which typically produces a noticeable amount of slimy materials, some of which is normally left behind as a “slime track” as the plasmodium migrates over the surface of a particular substrate. The study reported herein apparently represents the first attempt to in ...
DOI:
10.1186/s12896-017-0398-6
PubMed:
29121887
PubMed Central:
PMC5679387

21. C‐Glycosyl Flavonoids from Beta vulgaris Cicla and Betalains from Beta vulgaris rubra: Antioxidant, Anticancer and Antiinflammatory Activities—A Review

Author:
Paolino Ninfali; Elena Antonini; Alessandra Frati; Emanuele‐Salvatore Scarpa
Source:
Phytotherapy research 2017 v.31 no.6 pp. 871-884
ISSN:
0951-418X
Subject:
Beta vulgaris subsp. vulgaris; angiogenesis; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apigenin; apoptosis; beets; betacyanins; betalains; breasts; colon; gene expression regulation; genes; human health; hypoxia; liver; multiple drug resistance; neoplasm cells; phytopharmaceuticals; toxicity; urinary bladder neoplasms; vascular endothelial growth factors
Abstract:
... The green beet (Beta vulgaris var. cicla L.) and red beetroot (B. vulgaris var. rubra L.) contain phytochemicals that have beneficial effects on human health. Specifically, the green beet contains apigenin, vitexin, vitexin‐2‐O‐xyloside and vitexin‐2‐O‐rhamnoside, while the red beetroot is a source of betaxanthins and betacyanins. These phytochemicals show considerable antioxidant activity, as wel ...
DOI:
10.1002/ptr.5819

22. Nanoparticles based on crocin loaded chitosan-alginate biopolymers: antioxidant activities, bioavailability and anticancer properties

Author:
Somayeh Rahaiee; Maryam Hashemi; Seyed Abbas Shojaosadati; Sohrab Moini; Seyed Hadi Razavi
Source:
International journal of biological macromolecules 2017 pp. -
ISSN:
0141-8130
Subject:
2,2-diphenyl-1-picrylhydrazyl; absorption; antineoplastic activity; antineoplastic agents; antioxidant activity; bioactive compounds; bioavailability; biopolymers; carotenoids; free radical scavengers; heat; nanoparticles; oxidative stress; pH; saffron
Abstract:
... Crocin, a water-soluble carotenoid in saffron, is a highly bioactive compound with limited use due to instability to pH variations, heat and oxidative stress, rapid absorption and low bioavailability. In this study, chitosan-alginate nanoparticles, considered as a new vehicle for crocin to improve properties in terms of antioxidant activity, bioavailability and anticancer activity. The swelling of ...
DOI:
10.1016/j.ijbiomac.2017.02.095

23. Structural, physicochemical, antioxidant and antitumor property of an acidic polysaccharide from Polygonum multiflorum

Author:
Weili Zhu; Xiaoping Xue; Zhanjun Zhang
Source:
International journal of biological macromolecules 2017 v.96 pp. 494-500
ISSN:
0141-8130
Subject:
2,2-diphenyl-1-picrylhydrazyl; Fourier transform infrared spectroscopy; Reynoutria multiflora; antineoplastic activity; antineoplastic agents; antioxidant activity; arabinose; free radical scavengers; galactose; galacturonic acid; methylation; nuclear magnetic resonance spectroscopy; polysaccharides; rhamnose; weight loss
Abstract:
... In this study, the structural characterization, physicochemical property, antioxidant and antitumor activity of an acidic polysaccharide (APS) from Polygonum multiflorum were investigated. Monosaccharide composition analysis showed APS was composed of arabinose, rhamnose, galactose and galacturonic acid in the molar ratio of 1.23:1.32:1.48:1.00. The presence of uronic acid was also confirmed by th ...
DOI:
10.1016/j.ijbiomac.2016.12.064

24. Antioxidant and anticancer activities of Trigonella foenum-graecum, Cassia acutifolia and Rhazya stricta

Author:
Bayan Al-Dabbagh; Ismail A. Elhaty; Ala’a Al Hrout; Reem Al Sakkaf; Raafat El-Awady; S. Salman Ashraf; Amr Amin
Source:
BMC complementary and alternative medicine 2018 v.18 no.1 pp. 240
ISSN:
1472-6882
Subject:
2,2-diphenyl-1-picrylhydrazyl; Rhazya stricta; Senna alexandrina; Trigonella foenum-graecum; Western blotting; alternative medicine; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; cell cycle; colorimetry; cyclins; dose response; ethanol; fenugreek; flavonoids; hepatoma; human cell lines; human umbilical vein endothelial cells; humans; leaves; medicinal plants; neoplasm cells; plant extracts; protein content
Abstract:
... BACKGROUND: Here, we determined in vitro antioxidant activity, total phenols and flavonoids and evaluated antiproliferative activity of three medicinal plant extracts: Trigonella foenum-graecum (Fenugreek), Cassia acutifolia (Senna) and Rhazya stricta (Harmal). METHODS: The leaves of the three medicinal plants were extracted with 70% ethanol. Antioxidant activities of the extracts were determined ...
DOI:
10.1186/s12906-018-2285-7
PubMed:
30134897
PubMed Central:
PMC6103858

25. Antioxidant, antihypertensive, and anticancer activities of the flavonoid fractions from green, oolong, and black tea infusion waste

Author:
Zihan Xue; Jingya Wang; Zhongqin Chen; Qiqi Ma; Qingwen Guo; Xudong Gao; Haixia Chen
Source:
Journal of food biochemistry 2018 v.42 no.6 pp. e12690
ISSN:
0145-8884
Subject:
antihypertensive effect; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; beverages; black tea; blood pressure; dietary supplements; green tea; hepatoma; high performance liquid chromatography; hypertension; inhibitory concentration 50; kaempferol; mass spectrometry; metastasis; neoplasm cells; oolong tea; oxidative stress; peptidyl-dipeptidase A; principal component analysis; wastes
Abstract:
... The flavonoid fractions from green (GTF), oolong (OTF) and black tea (BTF) infusion waste were comparatively studied on the antioxidant, antihypertensive and anticancer activities. HPLC‐MS method was used to analyze the compositions of the flavonoid fractions. BTF exhibited the highest anti‐hypertension effect and anticancer activities. Quercetin‐3‐O‐rutinoside (QR) was highly related to angiotens ...
DOI:
10.1111/jfbc.12690

26. Antioxidative and anti-proliferative potential of Curculigo orchioides Gaertn in oxidative stress induced cytotoxicity: In vitro, ex vivo and in silico studies

Author:
Iram Iqbal Hejazi; Rashmin Khanam; Syed Hassan Mehdi; Abdul Roouf Bhat; M.Moshahid Alam Rizvi; Sonu Chand Thakur; Fareeda Athar
Source:
Food and chemical toxicology 2018 v.115 pp. 244-259
ISSN:
0278-6915
Subject:
2,2-diphenyl-1-picrylhydrazyl; Curculigo orchioides; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; caspase-3; caspase-8; cell culture; chemical constituents of plants; cytotoxicity; ethyl acetate; free radicals; gas chromatography-mass spectrometry; human cell lines; humans; inhibitory concentration 50; mitochondria; neoplasm cells; neoplasms; oxidative stress; proteins
Abstract:
... Plant phytoconstituents have been a valuable source of clinically important anticancer agents. Antioxidant and anticancerous activity of plant Curculigo orchioides Gaertn were explored In vitro antioxidant activity, antioxidant enzyme activity of oxidatively stressed tissue, and cell culture studies on human cancer cell lines HepG2, HeLa and MCF-7 were carried out. Active plant fractions were subj ...
DOI:
10.1016/j.fct.2018.03.013

27. Antitumor activity of Se-containing tea polysaccharides against sarcoma 180 and comparison with regular tea polysaccharides and Se-yeast

Author:
Lizeng Cheng; Liang Chen; Qiongqiong Yang; Yuanfeng Wang; Xinlin Wei
Source:
International journal of biological macromolecules 2018 v.120 pp. 853-858
ISSN:
0141-8130
Subject:
sarcoma; tea; dose response; body weight; thymus gland; antineoplastic activity; immunomodulators; models; remission; mice; antineoplastic agents; selenium; spleen; polysaccharides; dietary supplements; oral administration; antioxidant activity
Abstract:
... Selenium (Se)-containing polysaccharide, a Se-conjugate macromolecule, generally exhibited higher antitumor activity than its regular polysaccharide. Previously, we extracted Se-containing tea polysaccharides (Se-TPS) from Se-enriched tea, and explored its structure and antioxidant activity. In this study, we investigated antitumor activity of Se-TPS on sarcoma 180 (S-180), and compared with its r ...
DOI:
10.1016/j.ijbiomac.2018.08.154

28. Antitumor effect and molecular mechanism of antioxidant polysaccharides from Salvia miltiorrhiza Bunge in human colorectal carcinoma LoVo cells

Author:
Xingyu Wang; Anning Gao; Yadong Jiao; Yan Zhao; Xingbin Yang
Source:
International journal of biological macromolecules 2018 v.108 pp. 625-634
ISSN:
0141-8130
Subject:
2,2-diphenyl-1-picrylhydrazyl; Salvia miltiorrhiza; antineoplastic activity; antineoplastic agents; antioxidant activity; apoptosis; boiling; colorectal neoplasms; cytotoxicity; derivatization; dose response; ethanol; functional foods; galactose; glucose; high performance liquid chromatography; humans; hydroxyl radicals; interphase; neoplasm cells; oxygen; polysaccharides
Abstract:
... Salvia miltiorrhiza Bunge polysaccharides (SMP) was comprehensively investigated in this study. The polysaccharides were extracted by the method of water boiling and ethanol precipitation with high purity. The monosaccharide composition of SMP was characterized using the established HPLC-UV protocol with PMP precolumn derivatization, and the results indicate that the polysaccharides are mainly com ...
DOI:
10.1016/j.ijbiomac.2017.12.006

29. Bio-fabrication of silver nanoparticles using the leaf extract of an ancient herbal medicine, dandelion (Taraxacum officinale), evaluation of their antioxidant, anticancer potential, and antimicrobial activity against phytopathogens

Author:
Rijuta G. Saratale; Giovanni Benelli; Gopalakrishnan Kumar; Dong Su Kim; Ganesh D. Saratale
Source:
Environmental science and pollution research international 2018 v.25 no.11 pp. 10392-10406
ISSN:
0944-1344
Subject:
2,2-diphenyl-1-picrylhydrazyl; Fourier transform infrared spectroscopy; Pseudomonas syringae; Taraxacum officinale; X-ray diffraction; Xanthomonas axonopodis; agrochemicals; antibacterial properties; antineoplastic activity; antineoplastic agents; antioxidant activity; biofabrication; cytotoxicity; free radical scavengers; herbal medicines; humans; inhibitory concentration 50; leaf extracts; liver neoplasms; medicinal plants; nanosilver; neoplasm cells; nitric oxide; particle size; phytopharmaceuticals; plant pathogens; tetracycline; transmission electron microscopy; ultraviolet-visible spectroscopy
Abstract:
... In recent years, the use of nanoparticle-based antimicrobials has been increased due to many advantages over conventional agrochemicals. This study investigates the utilization of common medicinal plant dandelion, Taraxacum officinale, for the synthesis of silver nanoparticles (TOL-AgNPs). AgNPs were evaluated for antimicrobial activity against two important phytopathogens, Xanthomonas axonopodis ...
DOI:
10.1007/s11356-017-9581-5

30. Composition and antioxidant, antibacterial, and anti-HepG2 cell activities of polyphenols from seed coat of Amygdalus pedunculata Pall

Author:
Cairui Lu; Cong Li; Bang Chen; Yehua Shen
Source:
Food chemistry 2018 v.265 pp. 111-119
ISSN:
0308-8146
Subject:
2,2-diphenyl-1-picrylhydrazyl; 2,5-dihydroxybenzoic acid; Aspergillus niger; Bacillus cereus; Bacillus subtilis; Escherichia coli; Prunus; Staphylococcus aureus; antibacterial properties; antineoplastic activity; antineoplastic agents; antioxidant activity; apigenin; apoptosis; ascorbic acid; cell proliferation; cell viability; cyanidin; free radicals; gallic acid; human cell lines; hydrogen peroxide; iron; kaempferol; keracyanin; naringenin; polyphenols; quercetin; quercitrin; seed coat; superoxide anion; viability assays
Abstract:
... This study aims at identifying the composition of polyphenols present in Amygdalus pedunculata Pall seed coat (APSC), and characterizing their antioxidant, antibacterial, and anticancer activities. The polyphenols from APSC were composed of 32 compounds. The compounds with important biological activities included apigenin 7-O-glucoside (the main component; 34.53 mg/100 g), quercitrin (23.43 mg/100 ...
DOI:
10.1016/j.foodchem.2018.05.091

31. Enhanced antimicrobial, antioxidant and anticancer activity of Rhizophora apiculata: An experimental report

Author:
V. Ramalingam; R. Rajaram
Source:
3 Biotech 2018 v.8 no.4 pp. 200
ISSN:
2190-572X
Subject:
2,2-diphenyl-1-picrylhydrazyl; DNA; Fourier transform infrared spectroscopy; Rhizophora apiculata; analysis of variance; antimicrobial properties; antineoplastic activity; antineoplastic agents; antioxidant activity; apoptosis; bacteria; butanol; gallic acid; humans; hydrogen peroxide; hydroxyl radicals; lung neoplasms; membrane potential; methanol; mitochondrial membrane; neoplasm cells; rutin; solvents
Abstract:
... The present study is designed to evaluate the antimicrobial, antioxidant and anticancer activities of Rhizophora apiculata. Initially, the phenolic and flavonoid content was quantified in solvent extracts, and gallic acid and rutin were used as a control, respectively. Further, antimicrobial and minimal inhibitory activities of different solvent extracts were assessed against human clinical pathog ...
DOI:
10.1007/s13205-018-1222-2
PubMed:
29581932
PubMed Central:
PMC5866817

32. Hydroalcoholic extract of Spartium junceum L. flowers inhibits growth and melanogenesis in B16-F10 cells by inducing senescence

Author:
Valentina Nanni; Lorena Canuti; Angelo Gismondi; Antonella Canini
Source:
Phytomedicine 2018 pp. -
ISSN:
0944-7113
Subject:
DNA damage; Spartium junceum; abiotic stress; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; cell cycle checkpoints; cell proliferation; flowers; gas chromatography-mass spectrometry; high performance liquid chromatography; humans; in vitro studies; melanogenesis; melanoma; mice; myoblasts; neoplasm cells; plant extracts; quantitative polymerase chain reaction; secondary metabolites; shrubs; skin neoplasms; solar radiation; tissues; toxicity; ultraviolet radiation; viability
Abstract:
... Ultraviolet light exposure generates, in human tissues, radical species, which represent the main cause of photo-aging, DNA damage and skin cancer onset. On the other hand, Mediterranean plants, being continuously subjected to high solar radiation levels, are naturally adapted to take on this type of abiotic stress, thanks to the production of antioxidant secondary metabolites. For these reasons, ...
DOI:
10.1016/j.phymed.2018.06.008

33. Potential Anticancer Properties of Osthol: A Comprehensive Mechanistic Review

Author:
Yalda Shokoohinia; Fataneh Jafari; Zeynab Mohammadi; Leili Bazvandi; Leila Hosseinzadeh; Nicholas Chow; Piyali Bhattacharyya; Mohammad Hosein Farzaei; Ammad Ahmad Farooqi; Seyed Mohammad Nabavi; Mükerrem Betül Yerer; Anupam Bishayee
Source:
Nutrients 2018 v.10 no.1 pp. -
ISSN:
2072-6643
Subject:
adenocarcinoma; antineoplastic activity; antineoplastic agents; antioxidant activity; apoptosis; breast neoplasms; carcinogenesis; cell growth; cell proliferation; clinical trials; colon; coumarin; databases; drug therapy; glioblastoma; lungs; myeloid leukemia; neoplasm cells; prostatic neoplasms; signal transduction; tissues
Abstract:
... Cancer is caused by uncontrolled cell proliferation which has the potential to occur in different tissues and spread into surrounding and distant tissues. Despite the current advances in the field of anticancer agents, rapidly developing resistance against different chemotherapeutic drugs and significantly higher off-target effects cause millions of deaths every year. Osthol is a natural coumarin ...
DOI:
10.3390/nu10010036
PubMed:
29301373
PubMed Central:
PMC5793264

34. Stryphnodendron adstringens (“Barbatimão”) Leaf Fraction: Chemical Characterization, Antioxidant Activity, and Cytotoxicity Towards Human Breast Cancer Cell Lines

Author:
A. P. L. Sabino; L. M. S. Eustáquio; A. C. F. Miranda; C. Biojone; T. N. Mariosa; Cibele Marli Cação Paiva Gouvêa
Source:
Applied biochemistry and biotechnology 2018 v.184 no.4 pp. 1375-1389
ISSN:
0273-2289
Subject:
Stryphnodendron; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; breast neoplasms; caspase-3; caspase-8; caspase-9; cell viability; chemical composition; chemoprevention; cytotoxicity; gallic acid; human cell lines; humans; leaves; mechanism of action; neoplasm cells; procyanidins; shrinkage
Abstract:
... We evaluated the chemical composition, antioxidant activity, and antitumor potential of a fraction that was isolated from Stryphnodendron adstringens (barbatimão) leaf aqueous extract. Fraction is composed by gallic acid, procyanidin dimer B1, and (−)-epicatechin-3-O-gallate and it exhibits antioxidant and cytotoxic activities. Fraction was cytotoxic against two human breast cancer cell lines, ER ...
DOI:
10.1007/s12010-017-2632-z

35. Allium vegetables for possible future of cancer treatment

Author:
Yahya Asemani; Nasrindokht Zamani; Maryam Bayat; Zahra Amirghofran
Source:
Phytotherapy research 2019 v.33 no.12 pp. 3019-3039
ISSN:
0951-418X
Subject:
Allium; adverse effects; ajoene; antineoplastic activity; antineoplastic agents; antioxidant activity; apoptosis; cell cycle; chives; garlic; health effects assessments; ingredients; leeks; medicinal plants; metastasis; neoplasm cells; neoplasms; quercetin; shallots; signal transduction; sulfur; therapeutics; traditional medicine
Abstract:
... Natural resources such as plants are an upright curing option in treating cancers and reducing the side effects of current therapeutic modalities. Allium genus vegetables are of the most interesting herbs in restricting cancers that includes garlic, onions, leeks, chives, and shallots. These plants have been exploited in folk medicine because of their beneficial health effects in improving numerou ...
DOI:
10.1002/ptr.6490

36. Antioxidant, cytotoxicity and anti-tumor activity of Cordia dichotoma fruits accompanied with its volatile and sugar composition

Author:
Abeer Y. Ibrahim; Samah A. El-Newary; Gamil E. Ibrahim
Source:
Annals of agricultural science 2019 v.64 no.1 pp. 29-37
ISSN:
0570-1783
Subject:
Cordia dichotoma; alkaloids; alpha-phellandrene; alpha-terpineol; antineoplastic activity; antineoplastic agents; antioxidant activity; ascites; body weight; bornyl acetate; butyrates; carcinoma; catechin; chemical composition; cytotoxicity; dose response; fructose; fruit pulp; fruits; gallic acid; gas chromatography-mass spectrometry; glucose; hematologic tests; high performance liquid chromatography; ions; lethal dose 50; longevity; metals; mice; phenols; quercetin; sucrose; superoxide anion; tannins; volatile compounds
Abstract:
... The aim of the present research was to investigate the chemical composition, antioxidant and anti-tumor effects of Cordia dichotoma fruit pulp extract “CDFP-extract”. Day after intraperitoneal inoculation of Ehrlich ascites carcinoma (EAC) cells in mice, CDFP-extract was administered orally at 500 mg/kg body weight (equal to 0.10 of determined LD50) for ten consecutive days. CDFP-extract contains ...
DOI:
10.1016/j.aoas.2019.05.008

37. Assessing Anticancer Potential of Blueberry Flavonoids, Quercetin, Kaempferol, and Gentisic Acid, Through Oxidative Stress and Apoptosis Parameters on HCT-116 Cells

Author:
Ebru Demirel Sezer; Latife Merve Oktay; Elif Karadadaş; Hikmet Memmedov; Nur Selvi Gunel; Eser Sözmen
Source:
Journal of medicinal food 2019 v.22 no.11 pp. 1118-1126
ISSN:
1557-7600
Subject:
2,5-dihydroxybenzoic acid; Vaccinium myrtillus; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; blueberries; cytotoxicity; diet; flow cytometry; fruit extracts; kaempferol; liquid chromatography; neoplasms; oxidants; oxidative stress; polyphenols; protein composition; protein microarrays; proteins; quercetin; tandem mass spectrometry; therapeutics
Abstract:
... In recent years, natural products gained popularity with their anti-inflammatory and antioxidant effects mediated by chemical compounds within their composition. Study results offering them as palliative therapy options in cancer or as anticancer agents with high levels of cytotoxicity brought a new approach to combine cancer treatment protocols with these products. From a different perspective, e ...
DOI:
10.1089/jmf.2019.0098

38. Changes Over the Fermentation Period in Phenolic Compounds and Antioxidant and Anticancer Activities of Blueberries Fermented by Lactobacillus plantarum

Author:
Ji‐Yeon Ryu; Hye Rim Kang; Somi Kim Cho
Source:
Journal of food science 2019 v.84 no.8 pp. 2347-2356
ISSN:
0022-1147
Subject:
2,2-diphenyl-1-picrylhydrazyl; Lactobacillus plantarum; additives; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; blueberries; catechol; chlorogenic acid; epigallocatechin; ethanol; fermentation; free radicals; gallic acid; high performance liquid chromatography; human cell lines; lactic acid bacteria; malvidin; metabolites; phenol; polyphenols; protocatechuic acid; syringic acid; uterine cervical neoplasms
Abstract:
... This study determined the effects of blueberry fermentation by Lactobacillus plantarum on antioxidant and anticancer activities. The fermented blueberries extracted with 80% ethanol (FBE) showed increased superoxide dismutase‐like activity, increased scavenging of DPPH and alkyl radicals, and increased antiproliferative activity against human cervical carcinoma HeLa cells by inducing apoptosis. Se ...
DOI:
10.1111/1750-3841.14731

39. Extracts of Hypsizygus tessellatus (white var.) caps inhibited MCF-7 and MDA-MB-231 cell lines proliferation

Author:
C. I. Ukaegbu; S. R. Shah; H. A. Hamid; Z. Normaiza; O. R. Alara
Source:
Journal of food measurement & characterization 2019 v.13 no.1 pp. 368-382
ISSN:
2193-4126
Subject:
2,2-diphenyl-1-picrylhydrazyl; Hypsizygus; acetone; adverse effects; antineoplastic activity; antineoplastic agents; antioxidant activity; breast neoplasms; breasts; cell lines; chemical constituents of plants; drug therapy; ethyl acetate; free radical scavengers; hydrogen peroxide; inhibitory concentration 50; liquid chromatography; mass spectrometry; neoplasm cells
Abstract:
... Cancer management is associated with serious side-effects due to the harmful nature of radiation and chemotherapy on the body cells. These side-effects have necessitated the need for diversifying the alternative or complementary sources of cancer therapy. Natural products have been on the front line as alternative sources of anticancer agents and have attracted much attention in recent times. In t ...
DOI:
10.1007/s11694-018-9952-8

40. Inhibition of human breast cancer cells (MCF-7 cell line) growth via cell proliferation, migration, and angiogenesis by auraptene of Ferula szowitsiana root extract

Author:
Ensiyeh Charmforoshan; Ehsan Karimi; Ehsan Oskoueian; Ali Es-Haghi; Mehrdad Iranshahi
Source:
Journal of food measurement & characterization 2019 v.13 no.4 pp. 2644-2653
ISSN:
2193-4126
Subject:
2,2-diphenyl-1-picrylhydrazyl; Ferula; angiogenesis; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; breast neoplasms; caspase-3; caspase-8; cell proliferation; chemoprevention; coumarins; cytotoxicity; drug therapy; enriched foods; food industry; free radicals; functional foods; gene expression regulation; genes; human cell lines; inhibitory concentration 50; neoplasm cells; root extracts; vascular endothelial growth factor receptor-1; vascular endothelial growth factor receptor-2; Central Asia; Iran
Abstract:
... The different species of the Ferula (Apiaceae) genus are endemic in central Asia and are used as a medicinal food in Iran. The Ferula szowitsiana has been reported with anti-inflammatory, anti-hypertensive, anti-helicobacter, antileishmanial and cancer chemopreventive activities. Auraptene is one of the main coumarins from Ferula szowitsiana root. Despite the interesting biological properties of F ...
DOI:
10.1007/s11694-019-00185-6

41. Optimization of polysaccharide extraction process from grifola frondosa and its antioxidant and anti-tumor research

Author:
Xiaoyu Chen; Haiyu Ji; Xiaomeng Xu; Anjun Liu
Source:
Journal of food measurement & characterization 2019 v.13 no.1 pp. 144-153
ISSN:
2193-4126
Subject:
2,2-diphenyl-1-picrylhydrazyl; Grifola frondosa; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; human cell lines; microwave treatment; polysaccharides; raw materials; temperature; ultrasonics
Abstract:
... In order to get high yield polysaccharide from grifola frondosa, single factor experiment and an orthogonal experiment were applied to optimize the best extraction conditions. Extraction time, extraction temperature, ratio of raw material to water and auxiliary factors (microwave assisted, ultrasound assisted) were the main factors to influence the yield and purity of the extracted crude polysacch ...
DOI:
10.1007/s11694-018-9927-9

42. Phytochemical profiling, antioxidant and anticancer activities of Gastrocotyle hispida growing in Saudi Arabia

Author:
Abdelaaty A. Shahat; Syed Hidayathulla; Azmat A. Khan; Amer M. Alanazi; Osaid T. Al Meanazel; Ali S. Alqahtani; Mansour S. Alsaid; Ahmed A. Hussein
Source:
Acta tropica 2019 v.191 pp. 243-247
ISSN:
0001-706X
Subject:
2,2-diphenyl-1-picrylhydrazyl; Boraginaceae; aerial parts; antineoplastic activity; antineoplastic agents; antioxidant activity; beta-sitosterol; breast neoplasms; breasts; cell lines; chromatography; dose response; free radical scavengers; gallic acid; in vitro studies; inhibitory concentration 50; kidneys; leaves; liver; methanol; models; neoplasm cells; polyphenols; quercetin; rheumatoid arthritis; rosmarinic acid; tea; Saudi Arabia
Abstract:
... The present study aimed at isolation the phytocompounds from the aerial parts of Gastrocotyle hispida and to evaluate its antioxidant and anticancer potential using in vitro assay. Gastrocotyle hispida is belonging to the family Boraginaceae used as a refreshing drink like tea. The decoction of the leaves is diuretic and is used in the treatment of rheumatism. Phytochemical study of a methanol ext ...
DOI:
10.1016/j.actatropica.2019.01.013

43. Production and characterization of exopolysaccharides from Chlorella zofingiensis and Chlorella vulgaris with anti-colorectal cancer activity

Author:
Jianzhi Zhang; Lu Liu; Feng Chen
Source:
International journal of biological macromolecules 2019 v.134 pp. 976-983
ISSN:
0141-8130
Subject:
2,2-diphenyl-1-picrylhydrazyl; Chlorella vulgaris; antineoplastic activity; antineoplastic agents; antioxidant activity; cell viability; colorectal neoplasms; exopolysaccharides; human cell lines; humans; hydroxyl radicals; microalgae; molecular weight; neoplasm cells; sugars
Abstract:
... The production, physicochemical characteristics, antioxidant and antitumor activities of partial purified exopolysaccharides from Chlorella zofingiensis, Chlorella vulgaris were investigated. The final exopolysaccharides productions were 208.4, 364.3 mg/L and the average molecular weights were 2.66×104, 1.88×104 Da, respectively. Monosaccharide analysis indicating that these exopolysaccharides con ...
DOI:
10.1016/j.ijbiomac.2019.05.117

44. Effect of aqueous extracts of Ficus vogeliana Miq and Tieghemella africana Pierre in 7,12-Dimethylbenz(a)anthracene -induced skin cancer in rats

Author:
Rick-Léonid Ngoua Meye Misso; Fleury Augustin Nsole Biteghe; Cédric Sima Obiang; Joseph-Privat Ondo; Nan Gao; Miguel Cervantes-Cervantes; Guillaume Vignaux; Aurelia Vergeade; Jean Engohang-Ndong; Hugue Ella Mendene; Barthelemy Mabika; Félix Ovono Abessolo; Louis-Clement Obame Engonga; Jean De La Croix Ndong
Source:
Journal of ethnopharmacology 2020 v.263 pp. 113244
ISSN:
0378-8741
Subject:
2,2-diphenyl-1-picrylhydrazyl; Ficus; Tieghemella; alkaloids; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; carcinogenesis; inhibitory concentration 50; morbidity; mortality; phytochemicals; plant extracts; polyphenols; rats; screening; skin neoplasms; traditional medicine
Abstract:
... Skin cancer is the most common form of cancer responsible for considerable morbidity and mortality. Tieghemella africana and Ficus vogeliana are used in traditional medicine to treat cancers.Therefore, the aim of this study was to investigate the antioxidant, antiangiogenic and anti-tumor activities of these plant extracts.To achieve it, phytochemical screening, antioxidant activity and antiangiog ...
DOI:
10.1016/j.jep.2020.113244

45. Evaluation of biosynthesis parameters, stability and biological activities of silver nanoparticles synthesized by Cornus Officinalis extract under 365 nm UV radiation

Author:
Yinghui Wang; Simin Wei; Kang Wang; Zhe Wang; Jinwei Duan; Lin Cui; Huayu Zheng; Ying Wang; Shanshan Wang
Source:
RSC advances 2020 v.10 no.45 pp. 27173-27182
ISSN:
2046-2069
Subject:
Cornus officinalis; Escherichia coli; Oriental traditional medicine; Staphylococcus aureus; X-ray diffraction; antimicrobial properties; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; bacteria; biosynthesis; cytotoxicity; flow cytometry; human cell lines; light scattering; nanoparticles; nanosilver; pH; particle size; phytochemicals; plant extracts; silver nitrate; transmission electron microscopy; ultraviolet radiation; zeta potential
Abstract:
... Since silver nanoparticles (AgNPs) synthesized by using plant extracts revealed varied biological activities, the green synthesis of AgNPs has attracted considerable attention. Although the green synthesis of AgNPs have been accomplished by using the extracts of Cornus Officinalis, which is a traditional Chinese medicine and exhibits a wide spectrum of phytochemicals. The effects of biosynthesis p ...
DOI:
10.1039/d0ra04482b

46. Helichrysum italicum (Roth) G. Don essential oil: Composition and potential antineoplastic effect

Author:
Angelo Gismondi; Gabriele Di Marco; Antonella Canini
Source:
South African journal of botany 2020 v.133 pp. 222-226
ISSN:
0254-6299
Subject:
Helichrysum italicum; acetates; antineoplastic activity; antineoplastic agents; antioxidant activity; cell growth; chemotypes; cytotoxicity; dosage; essential oils; flowers; hydrodistillation; in vitro studies; limonene; literature; melanoma; mice; neoplasm cells; nerol; oils; phenylacetic acid; toxicity testing
Abstract:
... The antitumor effect of Helichrysum species has been rarely documented in literature. Thus, in the present work, the potential antineoplastic properties of the essential oil extracted from Helichrysum italicum (Roth) G. Don flower heads by hydrodistillation were investigated. The biochemical profile of the essential oil was characterized by GC–MS analysis: Neryl acetate (33.97%), α-Pinene (28.50%) ...
DOI:
10.1016/j.sajb.2020.07.031

47. Optimization of extraction process from Taraxacum officinale polysaccharide and its purification, structural characterization, antioxidant and anti-tumor activity

Author:
Xiaoyu Chen; Haiyu Ji; Chaofeng Zhang; Anjun Liu
Source:
Journal of food measurement & characterization 2020 v.14 no.1 pp. 194-206
ISSN:
2193-4126
Subject:
2,2-diphenyl-1-picrylhydrazyl; Taraxacum officinale; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; cell proliferation; enzymes; human cell lines; methylation; nuclear magnetic resonance spectroscopy; polysaccharides; raw materials; temperature; ultrasonics; uronic acids
Abstract:
... In order to get high yield polysaccharide from Taraxacum officinale, single factor experiment and an orthogonal experiment were applied to optimize the best extraction conditions. In this experiment, a novel comparison was made to explore and compare the effect of enzyme assisted and ultrasonic assisted hot water extraction of polysaccharide from T. officinale. The optimum conditions were as follo ...
DOI:
10.1007/s11694-019-00281-7

48. Polyphenols of Frangula alnus and Peganum harmala Leaves and Associated Biological Activities

Author:
Hosam O. Elansary; Agnieszka Szopa; Paweł Kubica; Halina Ekiert; Fahed A. Al-Mana; Ahmed A. El-Shafei
Source:
Plants 2020 v.9 no.9 pp. -
ISSN:
2223-7747
Subject:
Frangula alnus; Peganum harmala; antineoplastic activity; antineoplastic agents; antioxidant activity; caffeic acid; caspases; chlorogenic acid; cytotoxicity; diodes; ferulic acid; flow cytometry; high performance liquid chromatography; human cell lines; leaf extracts; leaves; neoplasm cells; p-coumaric acid; polyphenols; protocatechuic acid; quercetin; quercitrin; reactive oxygen species; rosmarinic acid; rutin; Saudi Arabia
Abstract:
... Frangula alnus and Peganum harmala populations growing in Saudi Arabia might be rich sources of natural compounds with important biological activities. A high performance liquid chromatography diode array revealed several polyphenols in the leaf extracts for the first time, including p-coumaric acid, rosmarinic acid, chlorogenic acid, ferulic acid, quercitrin, rutoside, quercetin and trifolin in F ...
DOI:
10.3390/plants9091086

49. Purification, partial structural characterization and health benefits of exopolysaccharides from potential probiotic Pediococcus acidilactici NCDC 252

Author:
Raman Kumar; Poonam Bansal; Jasbir Singh; Suman Dhanda
Source:
Process biochemistry 2020 v.99 pp. 79-86
ISSN:
1359-5113
Subject:
Pediococcus acidilactici; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; cell viability; colorectal neoplasms; computer simulation; dose response; ethanol; exopolysaccharides; gel chromatography; human health; humans; molecular weight; multigene family; neoplasm cells; probiotics; viability assays
Abstract:
... Probioceuticals are probiotic-derived biologically active compounds that positively influence human health. Exopolysaccharides (EPS) are long chain polymers of sugars and their derivatives with diverse biological functions. The objective of this work was to study EPS from Pediococcus acidilactici (PA) NCDC 252, a potential probiotic. In silico analysis of PA NCDC 252 genome revealed an EPS gene cl ...
DOI:
10.1016/j.procbio.2020.08.028

50. Sulfated modification, characterization, and potential bioactivities of polysaccharide from the fruiting bodies of Russula virescens

Author:
Hui Li; Xin Wang; Qian Xiong; Ying Yu; Lincai Peng
Source:
International journal of biological macromolecules 2020 v.154 pp. 1438-1447
ISSN:
0141-8130
Subject:
Russula; antibacterial properties; anticoagulant activity; anticoagulants; antineoplastic activity; antineoplastic agents; antioxidant activity; chemical structure; fruiting bodies; galactose; glucose; hydroxyl radicals; mannose; polysaccharides; pyridines; sulfates; sulfur; water solubility
Abstract:
... The water-soluble polysaccharide from fruiting bodies of Russula virescens (RVP) was sulfated using sulfur trioxide·pyridine complex method under different reaction conditions. Five sulfated RVP derivatives (SRVP₁–₅, SRV₁–₁₀, SRVP₁–₁₅, SRVP₁–₂₀ and SRVP₁–₂₅) with different degrees of substitution (DS) ranging from 0.34 to 0.73 were prepared. Several structural features of RVP and SRVPs including c ...
DOI:
10.1016/j.ijbiomac.2019.11.025

51. A caryophyllene oxide and other potential anticholinesterase and anticancer agent in Salvia verticillata subsp. amasiaca (Freyn & Bornm.) Bornm. (Lamiaceae)

Author:
Songul Karakaya; Serdar Volkan Yilmaz; Özlem Özdemir; Mehmet Koca; Nur Münevver Pınar; Betül Demirci; Kadir Yıldırım; Oksana Sytar; Hasan Turkez; K. Hüsnü Can Baser
Source:
Journal of essential oil research 2020 v.32 no.6 pp. 512-525
ISSN:
2163-8152
Subject:
Salvia; acetone; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; cell viability; cholinesterase; essential oils; monoterpenoids; research; spathulenol; trichomes
Abstract:
... In vitro cholinesterase inhibition, antioxidant and anticancer potentials of the essential oils and extracts of flowers and aerial parts of Salvia verticillata subsp. amasiaca have been studied. The GC-MS and GC-FID analyses found that major components of the essential oils were caryophyllene oxide, caryophylladienol II, spathulenol, hexahydrofarnesyl acetone and phytol. Oxygenated sesquiterpenes ...
DOI:
10.1080/10412905.2020.1813212

52. The remarkable role of emulsifier and chitosan, dextran and PEG as capping agents in the enhanced delivery of curcumin by nanoparticles in breast cancer cells

Author:
Malathi Sampath; Arunkumar Pichaimani; Premkumar Kumpati; Balasubramanian Sengottuvelan
Source:
International journal of biological macromolecules 2020 v.162 pp. 748-761
ISSN:
0141-8130
Subject:
antineoplastic activity; antineoplastic agents; antioxidant activity; bioavailability; breast neoplasms; cell growth; chitosan; curcumin; dextran; emulsifiers; emulsions; encapsulation; evaporation; solubility; solvents; succinic acid
Abstract:
... Curcumin has been found to be a powerful anti-cancer agent. However, its efficacy is limited by its poor solubility in aqueous medium. The bioavailability of curcumin was increased by poly (lactic-co-glycolic) acid [PLGA (60/40)] nanoparticles with different capping agents such as Chitosan, Dextran and PEG and emulsifier (Tocopherol Poly (Ethylene Glycol)1000 Succinate: TPGS) with good drug loadin ...
DOI:
10.1016/j.ijbiomac.2020.06.188

53. A thermophilic C-phycocyanin with unprecedented biophysical and biochemical properties

Author:
Giarita Ferraro; Paola Imbimbo; Angela Marseglia; Anna Illiano; Carolina Fontanarosa; Angela Amoresano; Giuseppe Olivieri; Antonino Pollio; Daria Maria Monti; Antonello Merlino
Source:
International journal of biological macromolecules 2020 v.150 pp. 38-51
ISSN:
0141-8130
Subject:
Cyanobacteria; Rhodophyta; antineoplastic activity; antineoplastic agents; antioxidant activity; biomedical research; circular dichroism spectroscopy; cosmetics; cytotoxicity; dietary supplements; energy transfer; fluorescence; fluorescence emission spectroscopy; food industry; hydrogen peroxide; mass spectrometry; neoplasm cells; neoplasms; oxidants; pH; pasteurization; pharmaceutical industry; pigments; polyacrylamide gel electrophoresis; proteins; temperature; ultraviolet-visible spectroscopy
Abstract:
... C-phycoyanins are abundant light-harvesting pigments which have an important role in the energy transfer cascade of photosystems in prokaryotic cyanobacteria and eukaryotic red algae. These proteins have important biotechnological applications, since they can be used in food, cosmetics, nutraceutical, pharmaceutical industries and in biomedical research. Here, C-phycocyanin from the extremophilic ...
DOI:
10.1016/j.ijbiomac.2020.02.045

54. Gender differences in the antioxidant response of oral administration of hydroxytyrosol and oleuropein against N-ethyl-N-nitrosourea (ENU)-induced glioma

Author:
M.J. Ramírez-Expósito; M.P. Carrera-González; M.D. Mayas; J.M. Martínez-Martos
Source:
Food research international 2021 v.140 pp. 110023
ISSN:
0963-9969
Subject:
N-ethyl-N-nitrosourea; animal models; antineoplastic activity; antineoplastic agents; antioxidant activity; blood chemistry; brain; brain neoplasms; carcinogenesis; food research; gender differences; glioma; metabolites; oleuropein; olives; oral administration; oxidative stress; phenolic compounds; rats; virgin olive oil
Abstract:
... Brain tumorigenesis has been associated not only with oxidative stress, but also with a reduced response of non-enzyme and enzyme antioxidant defense systems. In fact, the imbalance between free-radical production and the efficiency of the antioxidant defense systems triggers the process because the central nervous system (CNS) is very sensitive to free-radical damage. Phenolic compounds, mainly o ...
DOI:
10.1016/j.foodres.2020.110023

55. Phytochemical components, antioxidant and anticancer activity of 18 major medicinal plants in Albaha region, Saudi Arabia

Author:
Abdulrahman Ali Alzandi; Essam Ahmed Taher; Nageeb A. Al-Sagheer; Abdul Wali Al-Khulaidi; Mohamed Azizi; Deyala M. Naguib
Source:
Biocatalysis and agricultural biotechnology 2021 v.34 pp. 102020
ISSN:
1878-8181
Subject:
Aerva javanica; Dodonaea viscosa; Olea europaea subsp. cuspidata; Solanum incanum; agricultural biotechnology; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; ascorbic acid; biocatalysis; chemical constituents of plants; flavonoids; inhibitory concentration 50; medicinal plants; neoplasm cells; saponins; Saudi Arabia
Abstract:
... Medicinal plants have a great role in influencing health all over the world. There are few studies for the phytochemical investigations in medicinal plants were conducted in Saudi Arabia especially in Albaha region in south-western Saudi Arabia. Therefore this study focused on the detection of the phytochemical composition of the most dominant eighteen natural medicinal plant varieties found in Al ...
DOI:
10.1016/j.bcab.2021.102020

56. Production and Fractionation of Rocky Shore Crab (Grapsus albacarinous) Protein Hydrolysate by Ultrafiltration Membrane: Assessment of Antioxidant and Cytotoxic Activities

Author:
Mina Emadi Shaibani; Behrooz Heidari; Saber Khodabandeh; S. Shirin Shahangian
Source:
Journal of aquatic food product technology 2021 v.30 no.3 pp. 339-352
ISSN:
1547-0636
Subject:
antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; cancer therapy; crabs; cytotoxicity; foods; fractionation; hydrolysates; hydrophobicity; molecular weight; peptides; phase-contrast microscopy; protein hydrolysates; ultrafiltration
Abstract:
... Bioactive peptides from marine protein sources hold tremendous promise as potent antioxidant agents with plausible anticancer activity. Herein, the antioxidant activities of crab protein hydrolysate and its ultrafiltration fractions at different molecular weights (>30 kDa,10–30 kDa,3–10 kD and<3 kDa) using various methods (DPPH, ABTS and FRAP assay) were investigated carefully. The results showed ...
DOI:
10.1080/10498850.2021.1882631

57. The therapeutic effects of Ficus carica extract as antioxidant and anticancer agent

Author:
Raoufa Abdel-Rahman; Eglal Ghoneimy; Abeer Abdel-Wahab; Nehal Eldeeb; Marwa Salem; Eman Salama; Talaat Ahmed
Source:
South African journal of botany 2021 v.141 pp. 273-277
ISSN:
0254-6299
Subject:
Ficus carica; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; breast neoplasms; carcinoma; colorectal neoplasms; ethanol; free radicals; hepatoma; humans; inflammation; larynx; therapeutics
Abstract:
... Natural extracted ingredients are evolutionarily selected molecules and are used to control inflammation, and cancerous progression and transformation. Several studies have evaluated the beneficial properties of certain pharmaceutical molecules extracted from Ficus carica (FC). The current study aimed to investigate the antioxidant and anticancer properties of FC ethanolic leaves extract. The drie ...
DOI:
10.1016/j.sajb.2021.04.019

58. Antioxidant and anticancer activities of Annona muricata L. and Antidesma bunius L. leaves, and molecular networking analysis using LC-MS/MS metabolomics

Author:
Aya Gabriella Peña; Michael Russelle Alvarez; Kimberly Delica; Patrick Gabriel Moreno; Rowell Abogado; Sheryl Joyce Grijaldo; Edcyl Lee Salac; Froila Marie Deniega; Manolo Basingan; Cherry Mae Ravidas; Francisco Heralde; Gladys Cherisse Completo; Isagani Padolina; Ruel Nacario
Source:
South African journal of botany 2022 pp. -
ISSN:
0254-6299
Subject:
Annona muricata; Antidesma bunius; Philippines; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; chlorophyll; ethyl acetate; growth retardation; hexane; humans; indoles; leaves; lung neoplasms; metabolomics; methanol; phytochemicals; toxicity testing
Abstract:
... Several natural products are known to have anticancer activity, which helps prevent cancer. This study explores the potential use of different extracts of Annona muricata L. and Antidesma bunius L. leaves as an anticancer drug by testing its anti-oxidative and anticancer properties. Furthermore, metabolomics of these plant extracts was performed to characterize them. This project studied the bioac ...
DOI:
10.1016/j.sajb.2022.06.019

59. The Ferula Assa-foetida Essential Oil Nanoemulsion (FAEO-NE) as the Selective, Apoptotic, and Anti-Angiogenic Anticancer Compound in Human MCF-7 Breast Cancer Cells and Murine Mammary Tumor Models

Author:
Hanieh Azani; Masoud Homayouni Tabrizi; Ali Neamati; Farzanehsadat Khadem; Niloufar Khatamian
Source:
Nutrition and cancer 2022 v.74 no.6 pp. 2196-2206
ISSN:
1532-7914
Subject:
Ferula assa-foetida; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; beverages; breast neoplasms; cytotoxicity; drug delivery systems; essential oils; humans; mammary neoplasms (animal); mice; nanoemulsions; nutrition; traditional medicine; zeta potential
Abstract:
... The Ferula assa-foetida (FA) is the healthy common-consumed anticancer beverage in Iranian folk medicine. In the current study, we aimed to produce a nanoemulsion-based drug delivery system containing FA essential oil (FAEO) and evaluate its antioxidant and anticancer activity on both MCF-7 cells and murine mammary cancer tissue. The FAEO-loaded nanoemulsion (FAEO-NE) was produced and characterize ...
DOI:
10.1080/01635581.2021.1985533

60. Green synthesis of silver nanoparticles using Rhodiola imbricata and Withania somnifera root extract and their potential catalytic, antioxidant, cytotoxic and growth-promoting activities

Author:
Sahil Kapoor; Hemant Sood; Shweta Saxena; Om Prakash Chaurasia
Source:
Bioprocess and biosystems engineering 2022 v.45 no.2 pp. 365-380
ISSN:
1615-7591
Subject:
Hordeum vulgare; Rhodiola; Withania somnifera; agricultural industry; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; bioprocessing; carotenoids; cell lines; cell viability; chlorophyll; cytotoxicity; dose response; germination; nanosilver; neoplasm cells; p-nitrophenol; photosynthesis; pollutants; pollution; remediation; root extracts; silver nitrate; sustainable technology; zeta potential
Abstract:
... This study presents the development of a sustainable production process of environmentally benign silver nanoparticles (AgNPs) from aqueous root extract of Rhodiola imbricata (RI) and Withania somnifera (WS) for mitigating environmental pollution and investigating their potential applications in agriculture and biomedical industry. RIWS-AgNPs were characterized using several analytical techniques ...
DOI:
10.1007/s00449-021-02666-9