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1. Anti-tumor and antioxidant activity of kaempferol-3-O-alpha-L-rhamnoside (Afzelin) isolated from Pithecellobium dulce leaves

Author:
Masuma Akter; Mst. Shahnaj Parvin; Md. Mahadi Hasan; Md. Aziz Abdur Rahman; Md. Ekramul Islam
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 169
ISSN:
2662-7671
Subject:
2,2-diphenyl-1-picrylhydrazyl; Pithecellobium dulce; alternative medicine; antineoplastic activity; antioxidant activity; antioxidants; ascites; body weight; cell growth; chromatography; drug therapy; erythrocytes; ethyl acetate; fluorescence microscopes; free radicals; growth retardation; hemolysis; humans; lipid peroxidation; lipids; methanol; models; neoplasm cells; oxidation; plasmids; trees; vincristine; water solubility
Abstract:
... BACKGROUND: Pithecellobium dulce (Roxb.), an evergreen medium-sized, spiny tree which have vast nutritional values and widely used in ayurvedic medicines and home remedies. The plant has also been a rich source of biologically active compounds. The present study was designed to isolate pure compound from ethyl acetate fraction of methanol extract of leaves and to know the efficacy as antioxidant a ...
DOI:
10.1186/s12906-022-03633-x

2. The Anticancer Effect of Inula viscosa Methanol Extract by miRNAs’ Re-regulation: An in vitro Study on Human Malignant Melanoma Cells

Author:
Dilara Kamer Colak; Unal Egeli; Isil Ezgi Eryilmaz; Onder Aybastier; Hulusi Malyer; Gulsah Cecener; Berrin Tunca
Source:
Nutrition and cancer 2022 v.74 no.1 pp. 211-224
ISSN:
1532-7914
Subject:
Dittrichia viscosa; antineoplastic activity; antioxidant activity; apoptosis; cell cycle checkpoints; chromatography; drug therapy; fibroblasts; humans; melanoma; methanol; microRNA; nutrition; phenolic compounds; skin neoplasms
Abstract:
... Alternative and natural therapies are needed for malignant melanoma (MM), the most deadly skin cancer type due to chemotherapy’s limited effect. In the present study, we evaluated the anticancer potentials of Inula viscosa methanol and water extracts (IVM and IVW) on MM cells, A2058 and MeWo, and normal fibroblasts. After the chromatographic and antioxidant activity analysis, their antiproliferati ...
DOI:
10.1080/01635581.2020.1869791

3. Anticancer property of Selaginella bryopteris (L.) Bak. against hepatocellular carcinoma in vitro and in vivo

Author:
Lal Chand Pal; Arti Gautam; Veena Pande; Ch V Rao
Source:
Phytomedicine plus 2022 v.2 no.1 pp. 100201
ISSN:
2667-0313
Subject:
Selaginella bryopteris; acute toxicity; animal models; antineoplastic activity; antioxidant activity; apoptosis; carbon tetrachloride; caspase-3; caspase-9; catalase; cell viability; chemical constituents of plants; diethylnitrosamine; drugs; gallic acid; gas chromatography-mass spectrometry; gene expression; genes; hepatoma; histology; human cell lines; humans; imidazole; liver; liver function; lupeol; membrane potential; mitochondrial membrane; mortality; myo-inositol; neoplasm cells; palmitic acid; reactive oxygen species; reverse transcriptase polymerase chain reaction; silymarin; therapeutics; toxicity testing
Abstract:
... Hepatocellular carcinoma (HCC) is the most common and leading cause of cancer-related mortality worldwide. It has limited therapeutic options and side effects caused by current treatment methods. Selaginella bryopteris is used traditionally in the treatment of several health-related problems but mostly remains to be scientific validation. This study investigated the effect of Selaginella bryopteri ...
DOI:
10.1016/j.phyplu.2021.100201

4. Antimicrobial activity, in vitro anticancer effect (MCF-7 breast cancer cell line), antiangiogenic and immunomodulatory potentials of Populus nigra L. buds extract

Author:
Brigitta Kis; Ioana Zinuca Pavel; Stefana Avram; Elena Alina Moaca; Martina Herrero San Juan; Anja Schwiebs; Heinfried H. Radeke; Delia Muntean; Zorita Diaconeasa; Daliana Minda; Camelia Oprean; Florina Bojin; Cristina Adriana Dehelean; Codruta Soica; Corina Danciu
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 74
ISSN:
2662-7671
Subject:
Populus nigra; alternative medicine; antimicrobial properties; antineoplastic activity; antioxidant activity; apoptosis; breast neoplasms; cell cycle checkpoints; cell lines; cell viability; chemical constituents of plants; chorioallantoic membrane; dose response; humans; immunomodulators; interleukin-12; interleukin-23; neoplasm cells; toxicity; Romania
Abstract:
... PURPOSE: The aim of this study was to evaluate the antioxidant potential, antimicrobial activity, the in vitro anticancer effect (tested on MCF-7 breast cancer cell line), as well as the antiangiogenic and immunomodulatory potential of Populus nigra L. bud (Pg) extract collected from the western part of Romania. RESULTS: Populus nigra L. bud extract presents an important antioxidant activity, due ...
DOI:
10.1186/s12906-022-03526-z

5. Antioxidant and Anticancer Effects of Epsilon-Poly-L-lysine Produced by Two Novel Strains of Paenibacillus polymyxa HS6 and Stenotrophomonas maltophilia YS8

Author:
Hamidreza Hagh Ranjbar; Afrouzossadat Hosseini Abari; Seyed Mahdi Ghasemi; Najmeh Ghorbani
Source:
Biotechnology and bioprocess engineering 2022 v.27 no.4 pp. 586-595
ISSN:
1226-8372
Subject:
Fourier transform infrared spectroscopy; Paenibacillus polymyxa; Stenotrophomonas maltophilia; antineoplastic activity; antioxidant activity; antioxidants; bioactive compounds; bioprocessing; biotechnology; chemical precipitation; cytotoxicity; flow cytometry; high performance liquid chromatography; nucleotide sequences; polyacrylamide gel electrophoresis; polypeptides; sequence analysis; sodium; soil; thiazolyl blue
Abstract:
... Epsilon-Poly-L-lysine (ε-PL) is a non-toxic cationic homopolypeptide with unique bioactive properties. In this study, two novel polylysine producers, Paenibacillus polymyxa HS6 and Stenotrophomonas maltophilia YS8 were isolated from different soil samples and identified by 16S rDNA sequence analysis. To obtain pure cationic polypeptide from these bacteria, chemical precipitation with sodium tetrap ...
DOI:
10.1007/s12257-022-0065-1

6. Antioxidant and anticancer activities of Annona muricata L. and Antidesma bunius L. leaves, and molecular networking analysis using LC-MS/MS metabolomics

Author:
Aya Gabriella Peña; Michael Russelle Alvarez; Kimberly Delica; Patrick Gabriel Moreno; Rowell Abogado; Sheryl Joyce Grijaldo; Edcyl Lee Salac; Froila Marie Deniega; Manolo Basingan; Cherry Mae Ravidas; Francisco Heralde; Gladys Cherisse Completo; Isagani Padolina; Ruel Nacario
Source:
South African journal of botany 2022 pp. -
ISSN:
0254-6299
Subject:
Annona muricata; Antidesma bunius; Philippines; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; chlorophyll; ethyl acetate; growth retardation; hexane; humans; indoles; leaves; lung neoplasms; metabolomics; methanol; phytochemicals; toxicity testing
Abstract:
... Several natural products are known to have anticancer activity, which helps prevent cancer. This study explores the potential use of different extracts of Annona muricata L. and Antidesma bunius L. leaves as an anticancer drug by testing its anti-oxidative and anticancer properties. Furthermore, metabolomics of these plant extracts was performed to characterize them. This project studied the bioac ...
DOI:
10.1016/j.sajb.2022.06.019

7. Aqueous two-phase extraction of polysaccharides from Selaginella doederleinii and their bioactivity study

Author:
Gang Li; Xiankui Ma; Yongmei Jiang; Weiwei Li; Yongling Wang; Li Liu; Chengxin Sun; Shiji Xiao; Jie Lan; Juxiang Kuang; Gang Wang
Source:
Process biochemistry 2022 v.118 pp. 274-282
ISSN:
1359-5113
Subject:
Selaginella doederleinii; antineoplastic activity; antioxidant activity; antioxidants; ethanol; liquids; polysaccharides; salt concentration; thermogravimetry; ultrasonics
Abstract:
... In this study, the ethanol/salt aqueous two-phase system was firstly used to extract Selaginella doederleinii polysaccharides (SDP). Through single factor and response surface analysis, the best extraction conditions were as follows: extraction time of 40 min, ultrasonic power of 280 W, ethanol concentration of 35%, inorganic salt concentration of 0.22 g/mL, and liquid/solid ratio of 25 mL/g with ...
DOI:
10.1016/j.procbio.2022.04.024

8. Assessing the Protective Effect of Moringa oleifera Extract against Bone Metastasis: An In Vitro Simulated Digestion Approach

Author:
Kinjal P. Bhadresha; Nayan K. Jain; Rakesh M. Rawal
Source:
Nutrition and cancer 2022 v.74 no.3 pp. 1023-1036
ISSN:
1532-7914
Subject:
Moringa oleifera; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; bioactive compounds; bioavailability; cell lines; cell viability; cytotoxicity; digestion; flavonoids; gene expression; glutathione; interphase; metastasis; polyphenols; prostatic neoplasms; protective effect; spectral analysis
Abstract:
... Moringa oleifera possesses numerous advantageous effects like anti-microbial, antioxidant, and anti-inflammatory, leaves contain a high multiplicity of the bioactive compound; however, little is identified about its bioaccessibility. The objective of this study was to assess the bioefficacy, bioaccessible and anticancer activity of Moringa oleifera in a PC3 cell line before and after simulated in ...
DOI:
10.1080/01635581.2021.1933099

9. Assessment of antioxidant, antimicrobial, and anticancer activities of Sisymbrium officinale plant extract

Author:
Mahmoud Khalid; Mousa Amayreh; Saadi Sanduka; Zaidoun Salah; Fuad Al-Rimawi; Ghassab M. Al-Mazaideh; Abdulkareem A. Alanezi; Fadel Wedian; Fawaz Alasmari; Mohammed Helmy Faris Shalayel
Source:
Heliyon 2022 v.8 no.9 pp. e10477
ISSN:
2405-8440
Subject:
Escherichia coli; Gram-negative bacteria; Sisymbrium officinale; Staphylococcus; Streptococcus; air drying; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; breast neoplasms; breasts; cell lines; colon; ethanol; flavonoids; markets; neoplasm cells; plant extracts; ultrasonic treatment
Abstract:
... The most efficient and safe source of medications is the natural and traditional medications which are produced from plants and herbs. In this study, Sisymbrium officinale (S. officinale) was tested to explore its total phenolic and flavonoids contents. Antioxidant, antimicrobial, and anticancer activities were assessed as well. S. officinale was bought from a local Palestinian market, air-dried, ...
DOI:
10.1016/j.heliyon.2022.e10477

10. Bioactive Compounds, Antioxidant, Anti-Inflammatory, Anti-Cancer, and Toxicity Assessment of Tribulus terrestris—In Vitro and In Vivo Studies

Author:
Malik Waseem Abbas; Mazhar Hussain; Saeed Akhtar; Tariq Ismail; Muhammad Qamar; Zahid Shafiq; Tuba Esatbeyoglu
Source:
Antioxidants 2022 v.11 no.6 pp. -
ISSN:
2076-3921
Subject:
Tribulus terrestris; antineoplastic activity; antioxidant activity; blood serum; body weight; breast neoplasms; denaturation; drugs; edema; egg albumen; hemolysis; histopathology; metabolites; methanol; mice; myricetin; neoplasm cells; rutin; serum albumin; toxicity
Abstract:
... Tribulus terrestris L. belongs to the family Zygophyllaceae and integral part of various ancient medicinal systems including Chinese, Indian, and European to combat various health ailments. The aim of the present study was to assess the phytochemical constituents, in vitro antioxidant activity using DPPH, FRAP, and H₂O₂ assays, in vitro anticancer activity using MTT assay, and in vitro and in vivo ...
DOI:
10.3390/antiox11061160

11. Biochemical and mitochondrial membrane potential changes relating to betulinic acid-mediated anticancer activity in murine ascites Dalton's lymphoma

Author:
Anamika Bhaumik; Atanu Bhattacharjee; Surya Bali Prasad
Source:
Phytomedicine plus 2022 v.2 no.1 pp. 100211
ISSN:
2667-0313
Subject:
antineoplastic activity; antioxidant activity; ascites; betulinic acid; computer simulation; glutathione; longevity; lymphoma; membrane potential; mice; mitochondrial membrane; succinate dehydrogenase (quinone)
Abstract:
... Betulinic acid, a naturally occurring pentacyclic triterpenoid is found in a variety of plants. A range of biological properties including anticancer activity has been reported for betulinic acid. Changes in glutathione and some glutathione-related enzymes and mitochondrial membrane potential have not been explored relating to the anticancer activity of betulinic acid against murine ascites Dalton ...
DOI:
10.1016/j.phyplu.2021.100211

12. Biofunctionalized silver nanoparticles synthesized from Passiflora vitifolia leaf extract and evaluation of its antimicrobial, antioxidant and anticancer activities

Author:
Dhanyakumara Shivapoojar Basavarajappa; Raju Suresh Kumar; Abdulrahman I. Almansour; Bidhayak Chakraborty; Meghashyama Prabhakara Bhat; Shashiraj Kariyellappa Nagaraja; Halaswamy Hiremath; Karthikeyan Perumal; Sreenivasa Nayaka
Source:
Biochemical engineering journal 2022 pp. 108517
ISSN:
1369-703X
Subject:
Fourier transform infrared spectroscopy; Passiflora; X-ray diffraction; absorption; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; atomic force microscopy; cell lines; leaf extracts; macrophages; mice; nanosilver; transmission electron microscopy; zeta potential
Abstract:
... The present study describes the synthesis of silver nanoparticles (AgNPs) using Passiflora vitifolia (P. vitifolia) leaf extract as reducing and capping agent. Characterization of the synthesized AgNPs was done with the help of UV-Vis. spectroscopy, atomic force microscopy (AFM), fourier transform infrared microscopy (FTIR), zeta potential, thermo gravimetric analysis (TGA), scanning electron micr ...
DOI:
10.1016/j.bej.2022.108517

13. Biogenesis and characterization of proficient silver nanoparticles employing marine procured fungi Hamigera pallida and assessment of their antioxidative, antimicrobial and anticancer potency

Author:
Harsh Mistry; Rashmi Thakor; Himanshu Bariya
Source:
Biotechnology letters 2022 v.44 no.9 pp. 1097-1107
ISSN:
0141-5492
Subject:
X-ray diffraction; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; biogenesis; biosynthesis; biotechnology; breast neoplasms; cell lines; color; energy; filtrates; humans; nanosilver; particle size; ultraviolet-visible spectroscopy
Abstract:
... OBJECTIVE: To assess the anticancer potential of biosynthesized silver nanoparticles using marine derived fungi Hamigera pallida with their antibacterial and antioxidant activities. RESULTS: The biosynthesis of silver nanoparticles (AgNPs) was assessed by the change in color from bright yellow to dark brown. UV–Visible spectroscopy revealed its stability at 429 nm; ATR-FTIR spectroscopy revealed t ...
DOI:
10.1007/s10529-022-03287-2

14. Blue is not enough: biological activities of C‐phycocyanin extracts from Anabaena cylindrica

Author:
Inês PE Macário; Telma Veloso; Andreia PM Fernandes; Margarida Martins; Tânia R Dias; Helena Oliveira; Fernando JM Gonçalves; Sónia PM Ventura; Joana L Pereira
Source:
Journal of chemical technology and biotechnology 2022 v.97 no.5 pp. 1171-1179
ISSN:
0268-2575
Subject:
Anabaena cylindrica; Spirulina; antineoplastic activity; antioxidant activity; antioxidants; biocompatibility; biomass; biotechnology; dyes; feedstocks; freeze drying; phycocyanin
Abstract:
... BACKGROUND: Natural products are currently in the spotlight due to the increasing awareness of consumers. Among these products is phycocyanin (C‐PC), a blue colorant that can be extracted from cyanobacteria – a poorly explored feedstock – and applied in several fields, due to its argued health benefits. Arthropira (previously called Spirulina) is the major source of C‐PC nowadays, but within the s ...
DOI:
10.1002/jctb.7001

15. Chemical Composition of Reichardia tingitana Methanolic Extract and Its Potential Antioxidant, Antimicrobial, Cytotoxic and Larvicidal Activity

Author:
Salama A. Salama; Zarraq E. Al-Faifi; Yasser A. El-Amier
Source:
Plants 2022 v.11 no.15 pp. -
ISSN:
2223-7747
Subject:
Aedes aegypti; Bacillus cereus; Clostridium tetani; Reichardia; Salmonella Typhimurium; Staphylococcus xylosus; antineoplastic activity; antioxidant activity; antioxidants; chemical composition; cytotoxicity; larvicides; methanol; neoplasms; oleic acid; terpenoids
Abstract:
... The biggest challenges are locating effective, reasonably priced, and eco-friendly compounds to treat diseases caused by insects and microbes. The aim of this study was to employ GC-MS to assess the biological potency and chemical composition of the aerial parts of Reichardia tingitana (L.) Roth. Using this technique, 17 components were interpreted from the extracted plant, accounting for around 1 ...
DOI:
10.3390/plants11152028

16. Chemical Profiling and Evaluation of Antioxidant and Anticancer Potential of Tuber Crop Amorphophallus commutatus var. wayanadensis

Author:
Sreena Raj; Rama Jayaraj; Gothandam Kodiveri Muthukaliannan
Source:
Plant foods for human nutrition 2022 v.77 no.1 pp. 68-76
ISSN:
0921-9668
Subject:
Amorphophallus; DNA fragmentation; antineoplastic activity; antioxidant activity; apoptosis; ascites; carcinoma; caspase-3; cell cycle checkpoints; cytotoxicity; dietary supplements; fractionation; functional foods; health services; hematologic tests; herbaceous plants; human cell lines; human nutrition; longevity; therapeutics; toxicity testing; India
Abstract:
... Cancer and cancer-related diseases are a global health concern in the present scenario. Functional food and nutraceuticals are considered as a boon towards cancer management. Amorphophallus commutatus var. wayanadensis (ACW) is an herbaceous plant used by the local communities of Wayanad, India, for food and primary healthcare. Various radical scavenging and reducing power assays were undertaken t ...
DOI:
10.1007/s11130-021-00942-3

17. Comparative Evaluation of the Potential Antitumor of Helleborus purpurascens in Skin and Breast Cancer

Author:
Ciprian Nicolae Pilut; Aniko Manea; Ioana Macasoi; Amadeus Dobrescu; Doina Georgescu; Roxana Buzatu; Alin Faur; Stefania Dinu; Doina Chioran; Iulia Pinzaru; Monica Hancianu; Cristina Dehelean; Daniel Malița
Source:
Plants 2022 v.11 no.2 pp. -
ISSN:
2223-7747
Subject:
Helleborus; antineoplastic activity; antioxidant activity; apoptosis; ascorbic acid; breast neoplasms; cancer therapy; cell lines; cytotoxicity; epicatechin; kaempferol; neoplasm cells; quercetin
Abstract:
... In the field of oncology, the plant kingdom has an inexhaustible supply of bioactive compounds. Phytochemical compounds isolated from Helleborus species have been found to be useful in various chronic diseases. This has brought Helleborus to the attention of medical researchers. H. purpurascens is a plant characteristic of the Carpathian area, known since ancient times for its beneficial effects. ...
DOI:
10.3390/plants11020194

18. Cytotoxic effect of plant extract-based nanoparticles on cancerous cells: a review

Author:
Jyotika Grewal; Vijay Kumar; Hemant Rawat; Yashika Gandhi; Ravindra Singh; Arjun Singh; Gajji Babu; Narayanam Srikanth; Sujeet K. Mishra
Source:
Environmental chemistry letters 2022 v.20 no.4 pp. 2487-2507
ISSN:
1610-3653
Subject:
antineoplastic activity; antioxidant activity; apoptosis; autophagy; cell cycle checkpoints; cytotoxicity; drug delivery systems; environmental science; medicinal plants; reactive oxygen species
Abstract:
... Cancer is one of the most fatal diseases causing deaths of millions of people worldwide. Since actual cancer treatments are rarely efficient and often toxic, there is a demand for innocuous and more effective anticancer drugs. For instance, metal/metal oxide nanoparticles allow controlled drug release and drug delivery to specific targets. In particular, medicinal plant-based metal nanoparticles a ...
DOI:
10.1007/s10311-022-01422-z

19. Ecofriendly Synthesis of Biosynthesized Copper Nanoparticles with Starch-Based Nanocomposite: Antimicrobial, Antioxidant, and Anticancer Activities

Author:
Mohamed Hasanin; Mohamed A. Al Abboud; Mohamed M. Alawlaqi; Tarek M. Abdelghany; Amr H. Hashem
Source:
Biological trace element research 2022 v.200 no.5 pp. 2099-2112
ISSN:
0163-4984
Subject:
Aspergillus niger; Bacillus subtilis; Candida albicans; Escherichia coli; Fourier transform infrared spectroscopy; X-ray diffraction; antifungal properties; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; biosynthesis; cell lines; copper nanoparticles; energy-dispersive X-ray analysis; nanocomposites; research; starch; trace elements; transmission electron microscopes; ultraviolet-visible spectroscopy
Abstract:
... In recent years, polysaccharides-based nanocomposites have been used for biomedical applications. In the current study, a nanocomposite based on myco-synthesized copper nanoparticles (CuNPs) and starch was prepared. The prepared nanocomposite was fully characterized using UV–visible spectroscopy (UV–vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron mi ...
DOI:
10.1007/s12011-021-02812-0

20. Effects of Momordica cochinchinensis Aril Extract on Sterilized Low-Fat Milk, Antioxidant and Antiproliferative Activities

Author:
Thitiporn Anunthawan; Santi Phosri; Jirayus Woraratphoka; Rasapirose Somwatcharajit; Panee Terdsaksri; Prangruethai Prangphet
Source:
International Journal of Food Sciences 2022 v.2022 pp. -
ISSN:
2314-5765
Subject:
Momordica cochinchinensis; alcohols; antineoplastic activity; antioxidant activity; antioxidants; aril; fruit extracts; lipid peroxidation; low fat milk; neoplasm cells; sensory evaluation; shelf life; toxicity
Abstract:
... The aril extract (0.4% g/mL) of Gac fruit in milk supplement can inhibit cancer cell lines. Moreover, the extract has no toxicity against normal cells. In a sensory test, sterilized low-fat milk supplemented with 0.4% extract did not have different sensory score compared to the control. During the sterilization process, extract was not significantly different from the control. In sterilization (12 ...
DOI:
10.1155/2022/7934454

21. Effects of sulfation and carboxymethylation on Cyclocarya paliurus polysaccharides: Physicochemical properties, antitumor activities and protection against cellular oxidative stress

Author:
Liuming Xie; Zhibing Huang; Li Qin; Qiang Yu; Yi Chen; Haibing Zhu; Jianhua Xie
Source:
International journal of biological macromolecules 2022 v.204 pp. 103-115
ISSN:
0141-8130
Subject:
Cyclocarya paliurus; antineoplastic activity; antioxidant activity; apoptosis; cell cycle checkpoints; cell viability; glucose; interphase; lactate dehydrogenase; malondialdehyde; neoplasms; oxidative stress; phagocytosis; polysaccharides; secretion; superoxide dismutase
Abstract:
... The Cyclocarya paliurus polysaccharide (CP) was chemically modified to produce sulfated derivatives (S-CP) and carboxymethylated derivatives (CM-CP). Subsequently, the antioxidant activity, cytoprotective effect and antitumor activity of these derivatives were investigated to establish the relationship between their structure and functional activity. The results found that chemical modifications r ...
DOI:
10.1016/j.ijbiomac.2022.01.192

22. Evaluation of a novel phosphorylated corn straw xylan for enhancement of thermal stability, crystallinity and functional activity

Author:
Shiquan Qian; Yuting Yu; Jing Ma; Enjie Diao; Shijia Ye; Jiamin Gao; Ying Liu; Weicheng Hu
Source:
International journal of food science & technology 2022 v.57 no.1 pp. 481-488
ISSN:
0950-5423
Subject:
2,2-diphenyl-1-picrylhydrazyl; antineoplastic activity; antioxidant activity; corn straw; crystal structure; food science; hydroxyl radicals; spectral analysis; superoxide anion; technology; temperature; thermal analysis; thermal stability; xylan
Abstract:
... The present study focussed on a novel phosphorylated corn straw xylans (XYCS‐P) that had excellent thermal stability, crystallinity and functional activity and could be potentially used as functional agents in food products. In this work, the phosphorylated derivative XYCS‐P was successfully prepared, and the chemical characterisation, spectral analysis, thermal analysis, morphology analysis, anti ...
DOI:
10.1111/ijfs.15428

23. Exploring the pharmacognostic properties and pharmacological activities of phytocompounds present in Ficus racemosa linn.: A concise review

Author:
Nilanjan Pahari; Subhabrota Majumdar; Dipanjan Karati; Rana Mazumder
Source:
Pharmacological research 2022 v.4 pp. 100137
ISSN:
2667-1425
Subject:
Ficus racemosa; analgesics; antineoplastic activity; antioxidant activity; cognition; figs; habitats; larvicides; nematicides; research; therapeutics; China; India; Malaysia; Pakistan; Sri Lanka
Abstract:
... The genus Ficus is a very useful and significant group of trees with various therapeutic properties. Ficus racemosa linn. is a standard-sized tree in the Moraceae family, often known as the cluster fig tree. Ficus racemosa is also known as yajnayoga, udumbara, goolar, dumar, bodda, heibong, jantuphalam, dimri, yogga dumur, and many more names. Ficus racemosa may be found in various countries, incl ...
DOI:
10.1016/j.prmcm.2022.100137

24. Extraction of Zanthoxylum seed protein and identification of its simulated digestion products

Author:
Qingying Luo; Xiaomeng Li; Zhiqing Zhang; Anjun Chen; Shanshan Li; Guanghui Shen; Meiliang Li; Xingyan Liu; Xueqin Yin; Lan Cheng; Xingpan Yang; Chunping Jiang; Jianlong Li; Xiaoyan Hou
Source:
Lebensmittel-Wissenschaft + Technologie 2022 v.161 pp. 113412
ISSN:
0023-6438
Subject:
Zanthoxylum bungeanum; antibacterial properties; antineoplastic activity; antioxidant activity; antioxidants; antiviral properties; bioinformatics; byproducts; chemical precipitation; digestion; drugs; in vitro digestion; molecular weight; pH; peptides; temperature
Abstract:
... Zanthoxylum bungeanum seed is the main by-product of Z. bungeanum processing, which is rich in protein. In this study, Z. bungeanum seed proteins were extracted by alkali-soluble acid precipitation method. The factors affecting the protein yield were ranked as follows: alkali dissolution temperature > extraction time > material–liquid ratio > pH. The optimal process conditions were as follows: ext ...
DOI:
10.1016/j.lwt.2022.113412

25. The Ferula Assa-foetida Essential Oil Nanoemulsion (FAEO-NE) as the Selective, Apoptotic, and Anti-Angiogenic Anticancer Compound in Human MCF-7 Breast Cancer Cells and Murine Mammary Tumor Models

Author:
Hanieh Azani; Masoud Homayouni Tabrizi; Ali Neamati; Farzanehsadat Khadem; Niloufar Khatamian
Source:
Nutrition and cancer 2022 v.74 no.6 pp. 2196-2206
ISSN:
1532-7914
Subject:
Ferula assa-foetida; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; beverages; breast neoplasms; cytotoxicity; drug delivery systems; essential oils; humans; mammary neoplasms (animal); mice; nanoemulsions; nutrition; traditional medicine; zeta potential
Abstract:
... The Ferula assa-foetida (FA) is the healthy common-consumed anticancer beverage in Iranian folk medicine. In the current study, we aimed to produce a nanoemulsion-based drug delivery system containing FA essential oil (FAEO) and evaluate its antioxidant and anticancer activity on both MCF-7 cells and murine mammary cancer tissue. The FAEO-loaded nanoemulsion (FAEO-NE) was produced and characterize ...
DOI:
10.1080/01635581.2021.1985533

26. Genus Spatholobus: a comprehensive review on ethnopharmacology, phytochemistry, pharmacology, and toxicology

Author:
Yunlu Liu; Qian Xiang; Qi Liang; Jianyou Shi; Jun He
Source:
Food & function 2022 v.13 no.14 pp. 7448-7472
ISSN:
2042-650X
Subject:
Spatholobus; anemia; anti-inflammatory activity; antimicrobial properties; antineoplastic activity; antioxidant activity; drugs; flavonoids; health services; neuroprotective effect; pain; paralysis; structure-activity relationships; taxon descriptions; therapeutics; toxicity; traditional medicine
Abstract:
... Edible medicinal plants are important sources for the development of health beneficial products and drugs. Several species of the genus Spatholobus are considered as medicinal and food homologous plants in various Asian countries for the treatment of menstrual pain, anemia, paralysis, arthralgia, etc. Regarding this genus, mounting investigations on different aspects have been conducted; however, ...
DOI:
10.1039/d2fo00895e

27. Green synthesis of silver nanoparticles using Rhodiola imbricata and Withania somnifera root extract and their potential catalytic, antioxidant, cytotoxic and growth-promoting activities

Author:
Sahil Kapoor; Hemant Sood; Shweta Saxena; Om Prakash Chaurasia
Source:
Bioprocess and biosystems engineering 2022 v.45 no.2 pp. 365-380
ISSN:
1615-7591
Subject:
Hordeum vulgare; Rhodiola; Withania somnifera; agricultural industry; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; bioprocessing; carotenoids; cell lines; cell viability; chlorophyll; cytotoxicity; dose response; germination; nanosilver; neoplasm cells; p-nitrophenol; photosynthesis; pollutants; pollution; remediation; root extracts; silver nitrate; sustainable technology; zeta potential
Abstract:
... This study presents the development of a sustainable production process of environmentally benign silver nanoparticles (AgNPs) from aqueous root extract of Rhodiola imbricata (RI) and Withania somnifera (WS) for mitigating environmental pollution and investigating their potential applications in agriculture and biomedical industry. RIWS-AgNPs were characterized using several analytical techniques ...
DOI:
10.1007/s00449-021-02666-9

28. Improved water solubility, chemical stability, antioxidant and anticancer activity of resveratrol via nanoencapsulation with pea protein nanofibrils

Author:
Jiang Yi; Qingyu He; Gaofei Peng; Yuting Fan
Source:
Food chemistry 2022 v.377 pp. 131942
ISSN:
0308-8146
Subject:
antineoplastic activity; antioxidant activity; antioxidants; dietary supplements; fluorescence; food chemistry; hydrophobicity; nanocapsules; nanocarriers; nanofibers; pea protein; protein isolates; resveratrol; water solubility
Abstract:
... Fabricated pea protein isolate (PPI) nanofibrils were used as nanocarriers to encapsulate, stabilize and deliver resveratrol (RES). PPI nanofibrils possessed a dramatically higher surface hydrophobicity than PPI (native), and PPI nanofibrils exhibited nanoscale widths of 10 nm and average lengths of 1.0 μm. Fluorescence analyses demonstrated PPI nanofibrils had high binding constant with RES. Comp ...
DOI:
10.1016/j.foodchem.2021.131942

29. In Vitro Evaluation of Antioxidant and Anticancer Activity of Lemongrass (Cymbopogon citratus (D.C.) Stapf)

Author:
Daiane Pan; Larissa Machado; Claudia Giuliano Bica; Alencar Kolinski Machado; Jovani Antônio Steffani; Francine Carla Cadoná
Source:
Nutrition and cancer 2022 v.74 no.4 pp. 1474-1488
ISSN:
1532-7914
Subject:
Cymbopogon citratus; aerobiosis; antineoplastic activity; antioxidant activity; antioxidants; cell viability; cytotoxicity; drug therapy; fluorouracil; kidneys; nutrition; oxidative stress; rotenone; uterine cervical neoplasms
Abstract:
... Cancer is considered a multifactorial disease and its development could be associated with several factors, for example, rotenone exposition. Unfortunately, many cancers are resistant to chemotherapy, as cervical cancer. Regarding this, lemongrass is a remarkable natural product that presents antioxidant and anticancer activities, which could show therapeutic action against rotenone and cervical c ...
DOI:
10.1080/01635581.2021.1952456

30. Interactive 360° video to “Polyphenolic extracts of walnut (Juglans regia) green husk containing juglone inhibit the growth of HL-60 cells and induce apoptosis”

Author:
Carmen Soto-Maldonado; Mauricio Vergara-Castro; John Jara-Quezada; Eduardo Caballero-Valdés; Andrea Müller-Pavez; María Elvira Zúñiga-Hansen; Claudia Altamirano
Source:
Electronic Journal of Biotechnology 2022 v.57 pp. 52-53
ISSN:
0717-3458
Subject:
Juglans regia; antineoplastic activity; antioxidant activity; apoptosis; biotechnology; carcinogenicity; cell culture; dose response; fibroblasts; hulls; juglone; membrane potential; mitochondrial membrane; synthesis; viability; walnuts
Abstract:
... Juglone is a naphthoquinone currently obtained by chemical synthesis with biological activities including antitumor activity. Additionally, juglone is present in the green husk of walnut, which suggests evaluating the effect of GH extracts on carcinogenic cell lines. Walnut green husk ethanolic extract was obtained as 169.1 mg juglone/100 g Green Husk and antioxidant activity (ORAC) of 44,920 μmol ...
DOI:
10.1016/j.ejbt.2022.04.002

31. Investigation of antibacterial, antifungal, antibiofilm, antioxidant and anticancer properties of methanol extracts of Salvia marashica İlçim, Celep & Doğan and Salvia caespitosa Montbret & Aucher ex Benth plants with medicinal importance

Author:
Maside Temiz Bostanci; Ali Savas Bulbul; Ibrahim Seyfettin Celik; Yusuf Ziya Kocabas; Hakan Burhan; Ramazan Bayat; Fatih Sen; Nilofar Zakariae; Roghayeh Esmaeili; Hedayat Jafari; Fatemeh Karimi; Hassan Karimi-Maleh
Source:
Chemosphere 2022 v.288 pp. 132602
ISSN:
0045-6535
Subject:
Candida parapsilosis; Salvia; agar; antifungal properties; antineoplastic activity; antioxidant activity; antioxidants; cytotoxicity; human cell lines; inhibitory concentration 50; methanol; minimum inhibitory concentration
Abstract:
... In this study, Antimicrobial, Antifungal and Antibiofilm activity tests on 16 bacteria and 2 fungi of Salvia marashica İlçim, Celep & Doğan and Salvia caespitosa Montbret & Aucher ex Benth species were performed by Agar Well Diffusion and Microdilution methods. Salvia species showed sensitivity with a zone diameter of 12–16 mm. Concentrations of 0.5 mg/ml to 16 mg/ml by the dilution method were us ...
DOI:
10.1016/j.chemosphere.2021.132602

32. Isolation of Sesquiterpene Lactones and the Antioxidant and Anticancer Activities of Crude Extracts from Cyanthillium cinereum

Author:
J. Dharani; S. Ravi
Source:
Chemistry of natural compounds 2022 v.58 no.1 pp. 40-46
ISSN:
0009-3130
Subject:
Cyanthillium cinereum; DNA replication; antineoplastic activity; antioxidant activity; antioxidants; cell lines; cytotoxicity; interphase; sesquiterpenoid lactones
Abstract:
... Three sesquiterpene lactones has been isolated from Cyanthillium cinereum (L.) H. Rob. by bioactivity guided assay and characterized by spectral methods as compounds 1, 2, and 3. The in vitro anticancer activity was tested against 786-O, MCF-7, and K562 cells by the MTT assay. Compound 1 showed IC₅₀ values of 12.5 and 10.4 μg/mL against 786-O cell line after 48 and 72 h, respectively, and matches ...
DOI:
10.1007/s10600-022-03593-1

33. Isolation, structures and bioactivities of the polysaccharides from Radix Hedysari: A review

Author:
Xuelin Mo; Dongkai Guo; Yiguo Jiang; Ping Chen; Lifeng Huang
Source:
International journal of biological macromolecules 2022 v.199 pp. 212-222
ISSN:
0141-8130
Subject:
Oriental traditional medicine; antineoplastic activity; antioxidant activity; dose response; flavonoids; glycemic effect; glycosides; immunity; intestinal microorganisms; medicinal plants; molecular weight; phenylpropanoids; polysaccharides; structure-activity relationships; therapeutics; China
Abstract:
... Radix Hedysari, a well-known traditional Chinese herbal medicine, has a long history as a medicinal plant in China based on its wide spectrum of biological and pharmacological activities. Until now, many chemical constituents have been isolated and identified from Radix Hedysari, such as polysaccharides, flavonoids, phenylpropanoids, trace elements and so on. Of these, Radix Hedysari polysaccharid ...
DOI:
10.1016/j.ijbiomac.2021.12.095

34. Mesona chinensis polysaccharide/zein nanoparticles to improve the bioaccesibility and in vitro bioactivities of curcumin

Author:
Jun Yang; Jieqiong Lin; Xianxiang Chen; Liyuan Rong; Mingyue Shen; Yuanxing Wang; Jianhua Xie
Source:
Carbohydrate polymers 2022 v.295 pp. 119875
ISSN:
0144-8617
Subject:
Platostoma palustre; antineoplastic activity; antioxidant activity; apoptosis; curcumin; encapsulation; hepatoma; membrane potential; mitochondrial membrane; particle size; polysaccharides; zein
Abstract:
... The aim of this study was to enhance the stability, bioaccesibility, and bioactivities of curcumin using a composite nanoparticle prepared from zein and Mesona chinensis polysaccharide (MCP). Curcumin-loaded nanoparticles (ZMC NPs) were prepared. ZMC NPs showed smooth spherical structure with a high encapsulation efficiency (94 %), a small average particle size (223 nm), and surface negative charg ...
DOI:
10.1016/j.carbpol.2022.119875

35. Multi-Functional Development and Utilization of Rapeseed: Comprehensive Analysis of the Nutritional Value of Rapeseed Sprouts

Author:
Zelin Xiao; Yuying Pan; Chao Wang; Xiongcai Li; Yiqing Lu; Ze Tian; Lieqiong Kuang; Xinfa Wang; Xiaoling Dun; Hanzhong Wang
Source:
Foods 2022 v.11 no.6 pp. -
ISSN:
2304-8158
Subject:
alpha-tocopherol; amino acid composition; antineoplastic activity; antioxidant activity; beans; crude fiber; crude protein; germination; glucoraphanin; glucose; industry; magnesium; nutritive value; oil crops; rapeseed; selenium; China
Abstract:
... Rapeseed is the third largest oil crop in the world and the largest oil crop in China. The multi-functional development and utilization of rapeseed is an effective measure for the high-quality development of rapeseed industry in China. In this study, several basic nutrients of eight rapeseed sprouts and five bean sprouts (3–5 varieties each) were determined, including sugar, crude protein, crude f ...
DOI:
10.3390/foods11060778

36. Myrtus communis L. (Myrtle) plant parts: Comparative assessment of their chemical compositions, antioxidant, anticancer, and antimutagenic activities

Author:
Etil Guzelmeric; Pırıl Ugurlu; Cansel Celik; Nisa Beril Sen; Sinem Helvacıoglu; Mohammad Charehsaz; Murat Erdogan; Mehmet Ali Ockun; Hasan Kırmızıbekmez; Ahmet Aydın; Erdem Yesilada
Source:
South African journal of botany 2022 v.150 pp. 711-720
ISSN:
0254-6299
Subject:
Ames test; Myrtus communis; antineoplastic activity; antioxidant activity; colorectal neoplasms; food additives; gallic acid; humans; luteolin; mutagens; myricetin; neoplasm cells; nuclear magnetic resonance spectroscopy; quercitrin; superoxide anion; xanthine oxidase
Abstract:
... Myrtus communis L. (Myrtle) plant parts have been traditionally used to treat various disorders. Herein, we aimed to compare the chemical compositions, antioxidant, anticancer, and anti/-mutagenic activities of the hydroalcoholic extracts prepared from floral buds, flowers, leaves, and fruits of Myrtle. Quercitrin, myricitrin, and myricetin 3-O-β-galactopyranoside were identified in all plant part ...
DOI:
10.1016/j.sajb.2022.07.043

37. Newly crosslinked chitosan- and chitosan-pectin-based hydrogels with high antioxidant and potential anticancer activity

Author:
Michal Dziadek; Kinga Dziadek; Szymon Salagierski; Mariola Drozdowska; Andrada Serafim; Izabela-Cristina Stancu; Piotr Szatkowski; Aneta Kopec; Izabella Rajzer; Timothy E.L. Douglas; Katarzyna Cholewa-Kowalska
Source:
Carbohydrate polymers 2022 v.290 pp. 119486
ISSN:
0144-8617
Subject:
antineoplastic activity; antioxidant activity; antioxidants; chitosan; crosslinking; cytotoxicity; glass; hydrogels; mineralization; pectins; rosmarinic acid; strength (mechanics); therapeutics
Abstract:
... Monoaldehydes, due to natural origin and therapeutic activity, have attracted great attention for their ability to crosslink chitosan hydrogels for biomedical applications. However, most studies have focused on single-component hydrogels. In this work, chitosan-based hydrogels, crosslinked for the first time with 2,3,4-trihydroxybenzaldehyde (THBA), were modified with pectin (PC), bioactive glass ...
DOI:
10.1016/j.carbpol.2022.119486

38. Notes on Culturable Endophytic Microorganisms Isolated from 14 Medicinal Plants in Vietnam: A Diversity Analysis to Predict the Host-Microbe Correlations

Author:
Hanh My Tran; Dung Thuy Thi Nguyen; Ngan Thi Mai; Hien Thi Do; Thanh Kim Thi Nguyen; Thao Kim Nu Nguyen; Marc Muller; Huy Quang Nguyen; Hai The Pham
Source:
Current microbiology 2022 v.79 no.5 pp. 140
ISSN:
0343-8651
Subject:
anti-inflammatory activity; antibacterial properties; antineoplastic activity; antioxidant activity; biodiversity; endophytes; fungi; humans; nucleotide sequences; principal component analysis; secondary metabolites; socioeconomics; Vietnam
Abstract:
... Endophytes can generate a cornucopia of marvelous bioactive secondary metabolites useful for mankind but their biodiversity and associations with host plants are still elusive. In this study, we explored the culturable endophytic microorganisms associated with 14 medicinal plants that are of high socio-economic value and/or reportedly endemic to northern Vietnam. Specifically, we isolated the endo ...
DOI:
10.1007/s00284-022-02830-8

39. Novel studies of characterization, antioxidant, anticoagulant and anticancer activity of purified polysaccharide from Hypsizygus ulmarius mushroom

Author:
Alamelu Thimmaraju; Sudha Govindan
Source:
Bioactive carbohydrates and dietary fibre 2022 v.27 pp. 100308
ISSN:
2212-6198
Subject:
Fourier transform infrared spectroscopy; Hypsizygus; anticoagulants; antineoplastic activity; antioxidant activity; cytotoxicity; dietary fiber; galactose; gas chromatography-mass spectrometry; gel chromatography; glucose; high performance liquid chromatography; ion exchange chromatography; mannose; molecular weight; mushrooms; nuclear magnetic resonance spectroscopy; polysaccharides; rhamnose; superoxide anion; water solubility
Abstract:
... A water-soluble polysaccharide (HUP-2) was isolated from H. ulmarius using hot water extraction and purified using ion exchange chromatography (DEAE cellulose-52) and gel filtration (Sepharose-6B). The structure characteristics of HUP-2 were investigated using high performance liquid chromatography (HPLC), Fourier transform infrared (FT-IR), nuclear magnetic resonance (NMR) spectrum, and gas chrom ...
DOI:
10.1016/j.bcdf.2022.100308

40. Nutritional Value and Biological Activities of Sea Cucumber Holothuria scabra Cultured in the Open Pond System

Author:
Diah Anggraini Wulandari; Nunik Gustini; Tutik Murniasih; Asep Bayu; Martha Sari; Gita Syahputra; Iskandar Azmy Harahap; Abdullah Rasyid; Sari Budi Moria; Siti Irma Rahmawati; Fauzia Nurul Izzati; Eris Septiana; Fauzy Rachman; Masteria Yunovilsa Putra
Source:
Journal of aquatic food product technology 2022 v.31 no.6 pp. 599-614
ISSN:
1547-0636
Subject:
Holothuria scabra; antineoplastic activity; antioxidant activity; antioxidants; biomass production; breast neoplasms; breasts; cytotoxicity; flavonoids; foods; humans; maceration; nutritive value; pond culture; protein content
Abstract:
... The aim of this study was to investigate the production of H. scabra in an open pond culture system and to evaluate the nutritional value and biological activities. H scabra in this study was successfully grown with an average size 15.3 cm and weight 132.7 g after an eight month period. The H. scabra cultured was rich in protein content (73.41%). The extracts obtained from the soxhletation method ...
DOI:
10.1080/10498850.2022.2082902

41. Optimization, purification, and structure elucidation of anthraquinone pigment derivative from Talaromyces purpureogenus as a novel promising antioxidant, anticancer, and kidney radio-imaging agent

Author:
Yasmeen A. Hasanien; Amr A. Nassrallah; Amira G. Zaki; Gamal Abdelaziz
Source:
Journal of biotechnology 2022 v.356 pp. 30-41
ISSN:
0168-1656
Subject:
Talaromyces; anthraquinones; antineoplastic activity; antioxidant activity; antioxidants; bioassays; biotechnology; culture media; cytotoxicity; intravenous injection; kidney neoplasms; kidneys; neoplasm cells; pH; solid phase extraction; temperature; yeasts
Abstract:
... This study aims to investigate the bioproduction and prospective biological applications of a natural red pigment from Talaromyces purpureogenus AUMC2603. Maximum pigment yield was achieved by a numerical optimization at pH 6, temperature 25 °C, and an 18-day incubation period on Yeast Malt Broth (YMB) media. The crude pigment was separated and purified into two pigment fractions via solid-phase e ...
DOI:
10.1016/j.jbiotec.2022.07.002

42. Preparation and characterization of feruloylated oat β-glucan with antioxidant activity and colon-targeted delivery

Author:
Yun-Cheng Li; Yan Luo; Fan-Bing Meng; Jian Li; Wei-Jun Chen; Da-Yu Liu; Long-Hua Zou; Li Zhou
Source:
Carbohydrate polymers 2022 v.279 pp. 119002
ISSN:
0144-8617
Subject:
antineoplastic activity; antioxidant activity; antioxidants; chemoprevention; colon; colorectal neoplasms; crystal structure; digestion; ferulic acid; humans; oats; oligosaccharides; therapeutics; thermal stability; water solubility
Abstract:
... Ferulic acid (FA) is an effective chemopreventive and therapeutic agent for colorectal cancer. However, FA cannot stably reach the colon through human digestive system, and it can be grafted into oligosaccharides to improve its digestion stability. Therefore, in this study, different degrees of substitution of feruloylated oat β-glucan (FA-OβG) were prepared by grafting FA onto water soluble oat β ...
DOI:
10.1016/j.carbpol.2021.119002

43. Pt3R5G inhibits colon cancer cell proliferation through inducing ferroptosis by down-regulating SLC7A11

Author:
Lin Han; Yamei Yan; Meiyang Fan; Shanfeng Gao; Lingyu Zhang; Xiaofan Xiong; Rufeng Li; Xuan Xiao; Xiaofei Wang; Lei Ni; Dongdong Tong; Chen Huang; Youlong Cao; Juan Yang
Source:
Life sciences 2022 v.306 pp. 120859
ISSN:
0024-3205
Subject:
Lycium ruthenicum; antineoplastic activity; antioxidant activity; apoptosis; cell proliferation; colorectal neoplasms; drugs; ferroptosis; flow cytometry; genes; lipid peroxidation; malondialdehyde; mitochondria; neoplasm cells; petunidin; reactive oxygen species; sequence analysis; transmission electron microscopes; xenotransplantation
Abstract:
... Colon cancer (CC) is a prevalent malignancy worldwide and is one of the most easily altered cancers by dietary regulation. Petunidin 3-O-[rhamnopyranosyl-(trans-p-coumaroyl)]-5-O-(β-D-glucopyranoside) (Pt3R5G) isolated and purified from Lycium ruthenicum Murray, which exhibits highly efficient antioxidant activity and specific anticancer effects, is the flavonoids compound. We aimed to study the e ...
DOI:
10.1016/j.lfs.2022.120859

44. Quercetin attenuates the cardiotoxicity of doxorubicin–cyclophosphamide regimen and potentiates its chemotherapeutic effect against triple‐negative breast cancer

Author:
Puwei Zhang; Jianing Zhang; Lin Zhao; Shizheng Li; Kun Li
Source:
Phytotherapy research 2022 v.36 no.1 pp. 551-561
ISSN:
0951-418X
Subject:
adverse effects; antineoplastic activity; antioxidant activity; breast neoplasms; cardiomyocytes; cardiotoxicity; cyclophosphamide; doxorubicin; drug therapy; oxidative stress; phytotherapy; protective effect; quercetin; reactive oxygen species; research
Abstract:
... Doxorubicin combined with cyclophosphamide (AC) is the most commonly used regimen for triple‐negative breast cancer (TNBC) chemotherapy; however, its clinical application is severely limited by its serious adverse effect on cardiomyocytes. The cardiotoxicity of AC is mainly the result of oxidative stress caused by the imbalance between reactive oxygen species (ROS) and antioxidants, and it also in ...
DOI:
10.1002/ptr.7342

45. Serine O-acetyltransferase derived NV14 peptide reduces cytotoxicity in H2O2 induced MDCK cells and inhibits MCF-7 cell proliferation through caspase gene expression

Author:
Manikandan Velayutham; B. Haridevamuthu; P. Snega Priya; Munuswamy Ramanujam Ganesh; Annie Juliet; Jesu Arockiaraj
Source:
Molecular biology reports 2022 v.49 no.10 pp. 9205-9215
ISSN:
0301-4851
Subject:
Arthrospira platensis; adenocarcinoma; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; caspases; cell proliferation; computer simulation; cytotoxicity; dogs; epithelium; gene expression; human cell lines; humans; kidneys; molecular biology; oxidative stress; peptides; pharmacodynamics; serine O-acetyltransferase
Abstract:
... BACKGROUND: Most of the bioactive peptides exhibit antioxidant effect and do elicit inhibitory effect on proliferation of cancer cells. This study investigates the in-vitro antioxidant and anti-cancer properties of NV14 peptide, derived from serine O-acetyltransferase (SAT) of spirulina, Arthrospira platensis. METHODS: The anti-cancer effect of the peptide was evaluated using human adenocarcinoma ...
DOI:
10.1007/s11033-022-07746-x

46. Shahatra (F.parviflora Lam)- a comprehensive review of its ethnopharmacology, phytochemistry and pharmacology

Author:
F.N. Jamaldeen; Ghulamuddin Sofi; M.F.M. Fahim; Mohammed Aleem; E.M.G.K.N. Begum
Source:
Journal of ethnopharmacology 2022 v.286 pp. 114839
ISSN:
0378-8741
Subject:
Ayurvedic medicine; Internet; anthelmintics; antineoplastic activity; antioxidant activity; antiprotozoal properties; blood; bronchodilators; computer software; cytotoxicity; ethnobotany; glycemic effect; hepatoprotective effect; immunomodulation; mechanism of action; parasympatholytics; pharmacognosy; phytochemicals; temperament; trees; Iraq
Abstract:
... F.parviflora Lam. is a plant widely used in traditional medicine systems like Unani, Ayurveda, and folk medicines in Iraq and Turkey. It is known as Shahatraj in Arabic, which is derived from Shahatra and called Shajaratuddam. In the ancient Unani system, it is called Shajaratuddam. The term derived from Sajarat means tree, and Dam means blood since it has a potent blood purifier property.This rev ...
DOI:
10.1016/j.jep.2021.114839

47. Simultaneous Hydrolysis of Ellagitannins and Extraction of Ellagic Acid from Defatted Raspberry Seeds Using Natural Deep Eutectic Solvents (NADES)

Author:
Nemanja Teslić; Filipa Santos; Filipe Oliveira; Alena Stupar; Milica Pojić; Anamarija Mandić; Branimir Pavlić; Aleksandra Cvetanović Kljakić; Ana Rita C. Duarte; Alexandre Paiva; Aleksandra Mišan
Source:
Antioxidants 2022 v.11 no.2 pp. -
ISSN:
2076-3921
Subject:
antineoplastic activity; antioxidant activity; ellagic acid; hydrolysis; methanol; polyphenols; raspberries; response surface methodology; temperature
Abstract:
... Defatted raspberry seeds were used as an alternative source of antioxidants and ellagic acid (EA) extracted using Natural deep eutectic solvents (NADES). In the preliminary study, the best NADES combination (citric acid-betaine) and the most influential variables (temperature, time, and NADES/plant ratio) were selected for the further optimization process. All samples were analyzed in terms of tot ...
DOI:
10.3390/antiox11020254

48. Simultaneous detection of anticancer compounds (Cucurbitacin I, B and E) and some pharmacological properties of Indian Blastania species

Author:
Usmangani Abdul Attar; Savaliram Goga Ghane; Niranjana Sunil Chavan; Panditrao Dattaraya Shiragave
Source:
South African journal of botany 2022 v.147 pp. 871-881
ISSN:
0254-6299
Subject:
Bacillus cereus; Bacillus subtilis; Cucurbitaceae; Staphylococcus aureus; alpha-amylase; animal pathogens; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; cucurbitacins; diabetes; oxidative stress; principal component analysis
Abstract:
... Cucurbitacins are the predominant tetracyclic tri-terpenoids found in Cucurbitaceae members and possess several biological properties including anticancer. Therefore, the study was aimed at extracting and estimating three anticancer compounds viz. cucurbitacin I (CUI), cucurbitacin B (CUB) and cucurbitacin E (CUE) from two Cucurbitaceae species [Blastania cerasiformis (Stocks) A. Meeuse and Blasta ...
DOI:
10.1016/j.sajb.2022.03.019

49. Sodium alginate nanofibers loaded Terminalia catappa scaffold regulates intrinsic apoptosis signaling in skin melanoma cancer

Author:
Lakshmanan Muthulakshmi; Selvakani Prabakaran; Vaikundamoorthy Ramalingam; A. Varada Rajulu; Marriappan Rajan; Seeram Ramakrishna; Hongrong Luo
Source:
Process biochemistry 2022 v.118 pp. 92-102
ISSN:
1359-5113
Subject:
Fourier transform infrared spectroscopy; Terminalia catappa; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; cancer therapy; caspase-9; cytotoxicity; medicinal plants; melanoma; mitochondria; nanofibers; polymers; skin (animal); skin neoplasms; sodium alginate
Abstract:
... Drug delivery by nanofibrous scaffold is a promising approach for treating cancer disease. In this study, bioactive compounds were extracted from the medicinal plant Terminalia catappa and loaded into sodium alginate (SA) polymer to prepare a bioactive electrospun nanofibers. Initially, SA polymeric fibers alone was prepared by electrospinning approach and characterized by FT-IR spectroscopy, XRD ...
DOI:
10.1016/j.procbio.2022.04.004

50. Study of physicochemical, nutritional, and anticancer activity of Murraya Koenigii extract for its fermented beverage

Author:
Shriya Bhatt; Vikas Dadwal; Yogendra Padwad; Mahesh Gupta
Source:
Journal of food processing and preservation 2022 v.46 no.1 pp. e16137
ISSN:
0145-8892
Subject:
Bergera koenigii; Murraya; antineoplastic activity; antioxidant activity; antioxidants; curry; fermentation; fermented beverages; flavonoids; food intake; free amino acids; health promotion; indigenous knowledge; neoplasm cells; nutrition assessment; oxidative stress; polyphenols; quantitative analysis; ultra-performance liquid chromatography
Abstract:
... Murraya koenigii L (Curry) leaves, known for its natural polyphenols, possess efficient antioxidant properties that maintain oxidative stress and promote health benefits. Higher content of phenolics (77.00 µg GAE/mg) and flavonoids (21.02 µg RU/mg) was detected in M. koenigii leaves extract along with ultra‐performance liquid chromatography quantification (UPLC) followed by antioxidant activity. T ...
DOI:
10.1111/jfpp.16137