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1. 20 (S)-ginsenoside Rh2 inhibits colorectal cancer cell growth by suppressing the Axl signaling pathway in vitro and in vivo

Author:
Haibo Zhang; Jun-Koo Yi; Hai Huang; Sijun Park; Wookbong Kwon; Eungyung Kim; Soyoung Jang; Si-Yong Kim; Seong-kyoon Choi; Duhak Yoon; Sung-Hyun Kim; Kangdong Liu; Zigang Dong; Zae Young Ryoo; Myoung Ok Kim
Source:
Journal of Ginseng Research 2022 v.46 no.3 pp. 396-407
ISSN:
1226-8453
Subject:
Panax; Western blotting; antineoplastic activity; apoptosis; cell cycle checkpoints; cell growth; cell proliferation; colorectal neoplasms; morbidity; mortality; neoplasm cells; research; toxicity; transfection; xenotransplantation
Abstract:
... Colorectal cancer (CRC) has a high morbidity and mortality worldwide. 20 (S)-ginsenoside Rh2 (G-Rh2) is a natural compound extracted from ginseng, which exhibits anticancer effects in many cancer types. In this study, we demonstrated the effect and underlying molecular mechanism of G-Rh2 in CRC cells in vitro and in vivo. Cell proliferation, migration, invasion, apoptosis, cell cycle, and western ...
DOI:
10.1016/j.jgr.2021.07.004

2. ACSL4 promotes colorectal cancer and is a potential therapeutic target of emodin

Author:
Guoliang Dai; Dong Wang; Shitang Ma; Shengwei Hong; Kang Ding; Xiying Tan; Wenzheng Ju
Source:
Phytomedicine 2022 v.102 pp. 154149
ISSN:
0944-7113
Subject:
Rheum palmatum; Western blotting; antineoplastic activity; carcinogenesis; cell proliferation; colorectal neoplasms; data collection; databases; emodin; gene expression regulation; immunohistochemistry; ingredients; mice; mortality; secretion; therapeutics; vascular endothelial growth factor receptor-1; vascular endothelial growth factor receptor-2
Abstract:
... Colorectal cancer (CRC) is an important death-related disease in the world and new therapeutic strategies are urgently needed to reduce mortality. Several studies have demonstrated that emodin, the main ingredient of Rheum palmatum, fights cancer but its potential anti-tumor effect on CRC is still unknown. The present study is aimed to explore the potential anti-tumor effects of emodin against CRC ...
DOI:
10.1016/j.phymed.2022.154149

3. Abietane diterpenes from the twigs and leaves of Cephalotaxus oliveri Mast. with antitumor activity

Author:
Chunyu Jiang; Mengyue Yang; Chunxue Zhao; Fangshen Liu; Hangao Yang; Zhanlin Li; Tong Han; Bin Lin; Dahong Li; Huiming Hua
Source:
Phytochemistry 2022 v.199 pp. 113187
ISSN:
0031-9422
Subject:
Cephalotaxus; antineoplastic activity; apoptosis; circular dichroism spectroscopy; cytotoxicity; diterpenoids; humans; neoplasm cells; plant biochemistry; spectral analysis
Abstract:
... Twenty one abietane diterpenes were isolated from Cephalotaxus oliveri Mast. The structures of 7 undescribed diterpenoids, named cephaloliverins A-G, were elucidated via spectroscopic data interpretation and electronic circular dichroism (ECD) analysis. The isolated diterpenoids were evaluated for their cytotoxicity against three kinds of human tumor cell lines (MCF-7, HepG2, and A549). Metaglypti ...
DOI:
10.1016/j.phytochem.2022.113187

4. Access to 3-Amino-[1,2,4]-triazolo Pyridines and Related Heterocycles via Electrochemically Induced Desulfurative Cyclization

Author:
Yunfei Hu; Li Chen; Canlin Zou; Jiangtao He; Luanqi Feng; Jia-Qiang Wu; Wen-Hua Chen; Jinhui Hu
Source:
Organic letters 2022 v.24 no.28 pp. 5137-5142
ISSN:
1523-7052
Subject:
antineoplastic activity; electrochemistry; isothiocyanates; pyridines
Abstract:
... An efficient, one-pot approach has been established for synthesizing a wide range of 3-amino-[1,2,4]-triazolo pyridines and related heterocycles from the electrochemically induced desulfurative cyclization of 2-hydrazinopyridines with isothiocyanates. The protocol allows for the formation of C–N bonds under simple conditions without transition metals or external oxidants. The practicability of thi ...
DOI:
10.1021/acs.orglett.2c01968

5. Acetylshikonin exerts anti-tumor effects on non-small cell lung cancer through dual inhibition of STAT3 and EGFR

Author:
Yemeng Tang; Yanmao Wang; Xian Wang; Zhucheng Zhao; Haijian Cai; Mengyao Xie; Xintong Jiang; Luyao Zhang; Jiayun Cheng; Lehe Yang; Liangxing Wang; Chengguang Zhao; Xiaoying Huang
Source:
Phytomedicine 2022 v.101 pp. 154109
ISSN:
0944-7113
Subject:
antineoplastic activity; antineoplastic agents; apoptosis; cell movement; drug resistance; epidermal growth factor receptors; flow cytometry; fluorescent antibody technique; humans; lung neoplasms; mechanism of action; models; morbidity; phosphorylation; proteome; signal transduction; survival rate; tetrazolium; transactivators; xenotransplantation
Abstract:
... Lung cancer is one of the most common types of malignant tumor. It has one of the highest morbidity and mortality rates worldwide, and approximately 85% of cases are non-small cell lung cancer (NSCLC). Clinically, several EGFR inhibitors have been used to treat NSCLC, but resistance can develop. Studies have shown that cross talk between signal transducer and activator of transcription 3 (STAT3) a ...
DOI:
10.1016/j.phymed.2022.154109

6. Acid-sensitive charge-reversal co-assembled polyurethane nanomicelles as drug delivery carriers

Author:
Jingyi Liu; Zhoutong Dai; Yu Zhou; Wangwang Tao; Hongxiang Chen; Zuyi Zhao; Xinghua Liao
Source:
Colloids and surfaces 2022 v.209 pp. 112203
ISSN:
0927-7765
Subject:
Fourier transform infrared spectroscopy; antineoplastic activity; blood; cytotoxicity; drugs; electrostatic interactions; gel chromatography; micelles; neoplasms; nuclear magnetic resonance spectroscopy; pH; polyurethanes
Abstract:
... In order to obtain drug delivery carriers with good stability in blood and high cellular uptake efficiency, carboxyl groups and tertiary amine groups were respectively introduced into polyurethane to synthesize two kinds of amphiphilic polyurethanes with opposite charges (PUC and PUN). Their structures were characterized by Fourier transform infrared (FTIR) spectroscopy, nuclear magnetic resonance ...
DOI:
10.1016/j.colsurfb.2021.112203

7. Activities of the soluble and non-digestible longan (Dimocarpus longan Lour.) polysaccharides against HCT-116 cells as affected by a chemical selenylation

Author:
Ya-Hui Yu; Li Wang; Qiang Zhang; Xiao-Nan Zhang; Xin-Huai Zhao
Source:
Current research in food science 2022 v.5 pp. 1071-1083
ISSN:
2665-9271
Subject:
Dimocarpus longan; antineoplastic activity; apoptosis; calcium; cell growth; colorectal neoplasms; food science; humans; longans; membrane potential; mitochondrial membrane; polysaccharides; reactive oxygen species; research; sulfates; uronic acids
Abstract:
... The soluble and non-digestible longan (Dimocarpus longan Lour.) polysaccharides (LP) with Se content less than 0.01 g/kg were extracted and selenylated chemically with the HNO₃–Na₂SeO₃ system, to prepare two selenylated products namely SeLP1 and SeLP2 with enhanced Se contents of 1.46 and 4.79 g/kg, respectively. LP, SeLP1, and SeLP2 were then measured and compared for their saccharide features an ...
DOI:
10.1016/j.crfs.2022.06.008

8. Agrimonolide inhibits cancer progression and induces ferroptosis and apoptosis by targeting SCD1 in ovarian cancer cells

Author:
Ying Liu; Xiaobei Liu; Hui Wang; Pingping Ding; Changlin Wang
Source:
Phytomedicine 2022 v.101 pp. 154102
ISSN:
0944-7113
Subject:
Agrimonia pilosa; antineoplastic activity; apoptosis; computer software; databases; energy; ferroptosis; flow cytometry; immunoblotting; iron; models; mortality; neoplasm cells; neoplasm progression; ovarian neoplasms; reactive oxygen species; toxicity testing; toxicogenomics; xenotransplantation
Abstract:
... Ovarian cancer is a gynaecological tumour has high incidence and mortality rates. Agrimonolide, isolated from Agrimonia pilosa Ledeb, has multiple biomedical activities, including anticancer activity. Here, we aimed to reveal the function of agrimonolide on ovarian cancer progression. MTT assay, colony-formation assay, flow cytometry, transwell assay, scratch test, western immunoblotting, reactive ...
DOI:
10.1016/j.phymed.2022.154102

9. Alnustone inhibits the growth of hepatocellular carcinoma via ROS‐ mediated PI3K/Akt/mTOR/p70S6K axis

Author:
Linlin Wang; Li Cheng; Li Ma; Ammad Ahmad Farooqi; Gan Qiao; Yuxi Zhang; Hanlin Ye; Minghua Liu; Jianlin Huang; Xiaohui Yang; Xiukun Lin; Shousong Cao
Source:
Phytotherapy research 2022 v.36 no.1 pp. 525-542
ISSN:
0951-418X
Subject:
acetylcysteine; antineoplastic activity; antineoplastic agents; apoptosis; growth retardation; hepatoma; humans; liver; membrane potential; mitochondrial membrane; phytotherapy; research; xenotransplantation
Abstract:
... Alnustone, a diarylheptane compound, exhibits potent growth inhibition against hepatocellular carcinoma (HCC) BEL‐7402 cells. However, the underlying mechanisms associated with its anticancer activity remain unknown. In the present study, we evaluated the anticancer effect of alnustone against several human cancers focused on HCC and the possible associated mechanisms. The results showed that alnu ...
DOI:
10.1002/ptr.7337

10. Amyloid Protein-Biofunctionalized Polydopamine Nanoparticles Demonstrate Minimal Plasma Protein Fouling and Efficient Photothermal Therapy

Author:
Miaomiao Han; Yan Li; Shun Lu; Biao Yuan; Shujie Cheng; Chongjiang Cao
Source:
ACS applied materials & interfaces 2022 v.14 no.11 pp. 13743-13757
ISSN:
1944-8252
Subject:
adhesion; adsorption; amyloid; antineoplastic activity; bioavailability; biomimetics; camouflage; catechin; cell proliferation; disulfides; hydrophobicity; inflammation; irradiation; isoelectric point; neoplasm cells; neoplasms; phosphine; photothermotherapy; protein corona
Abstract:
... Polydopamine (PDA) shows great application potential in photothermal therapy (PTT) of tumors due to its excellent photothermal performance. However, PDA rich in a large number of catechin structures, with strong adhesion, can readily attach to plasma proteins in blood to form protein corona, which greatly hinders the transfer efficiency to tumors and reduces the bioavailability. In this paper, a s ...
DOI:
10.1021/acsami.2c00716

11. Andrographolide, a diterpene lactone from the Traditional Chinese Medicine Andrographis paniculate, induces senescence in human lung adenocarcinoma via p53/p21 and Skp2/p27

Author:
Junqian Zhang; Chunjie Li; Li Zhang; Yongqing Heng; Shiwen Wang; Yongfu Pan; Lili Cai; Yunjing Zhang; Tong Xu; Xihui Chen; Robert M Hoffman; Lijun Jia
Source:
Phytomedicine 2022 v.98 pp. 153933
ISSN:
0944-7113
Subject:
Andrographis; DNA damage; Oriental traditional medicine; adenocarcinoma; andrographolide; anti-inflammatory agents; antineoplastic activity; cancer therapy; cell cycle checkpoints; cell proliferation; cell senescence; flow cytometry; humans; lung neoplasms; lungs; mice; neoplasm cells; protein content; xenotransplantation
Abstract:
... Senescence leads to permanent cell-cycle arrest and is a potential target for cancer therapy. Andrographolide (AD) is a diterpene lactone isolated from Traditional Chinese Medicine (TCM) Andrographis paniculate, which has been used as an anti-inflammatory drug in clinical practice with the potential to target senescence in recalcitrant lung cancer. To determine whether AD can induce senescence in ...
DOI:
10.1016/j.phymed.2022.153933

12. Annona cherimola Mill. Leaf Extracts Affect Melanoma Cells Growth and Progression

Author:
Domenico Iacopetta; Alessia Fazio; Chiara La Torre; Alexia Barbarossa; Jessica Ceramella; Fabrizio Francomano; Carmela Saturnino; Hussein El-Kashef; Stefano Alcaro; Maria Stefania Sinicropi
Source:
Foods 2022 v.11 no.16 pp. -
ISSN:
2304-8158
Subject:
Annona cherimola; antineoplastic activity; antioxidants; apoptosis; cell lines; cytoskeleton; dietary supplements; leaves; melanoma; mortality; skin neoplasms; therapeutics
Abstract:
... Cancer represents one of the major causes of mortality worldwide; indeed, 19.3 million new cases and almost 10.0 million deaths were estimated last year. Among the different type of cancers, malignant melanoma represents the most aggressive and deadly skin cancer. Unfortunately, the long-term efficacy of melanoma treatments is limited by the lack of clinical efficacy, onset of side effects and res ...
DOI:
10.3390/foods11162420

13. Anti-tumor activity of polysaccharides extracted from Pinus massoniana pollen in colorectal cancer- in vitro and in vivo studies

Author:
Hongqi Shang; Xiangyun Niu; Wenping Cui; Zhou Sha; Cheng Wang; Teng Huang; Ping Guo; Xiangkun Wang; Panpan Gao; Shuyu Zhang; Kai Wei; Ruiliang Zhu
Source:
Food & function 2022 v.13 no.11 pp. 6350-6361
ISSN:
2042-650X
Subject:
Pinus massoniana; antineoplastic activity; apoptosis; cell proliferation; colorectal neoplasms; metastasis; mortality; pollen; polysaccharides; toxicity; China
Abstract:
... The prevalence and mortality rate of colorectal cancer (CRC) have been increasing dramatically worldwide. Pinus massoniana pollen, a well-known natural food, is one of the most commonly consumed traditional medicines in China. P. massoniana pollen polysaccharides (PPPS) have antitumor effects, but it remains unclear whether they can inhibit CRC. Here, we have demonstrated that PPPS inhibited CRC c ...
DOI:
10.1039/d1fo03908c

14. Anti-tumor effect of Inonotus hispidus petroleum ether extract in H22 tumor-bearing mice and analysis its mechanism by untargeted metabonomic

Author:
Zhijun Li; Haiying Bao
Source:
Journal of ethnopharmacology 2022 v.285 pp. 114898
ISSN:
0378-8741
Subject:
Inonotus hispidus; Oriental traditional medicine; alanine; antineoplastic activity; aspartic acid; biosynthesis; blood serum; corticosterone; cortisol; energy; fumarates; glutamic acid; histopathology; lysine; malates; metabolomics; models; mushrooms; neoplasms; petroleum; steroid hormones; succinic acid; tricarboxylic acid cycle; tryptophan; ultra-performance liquid chromatography; China
Abstract:
... The mushroom Inonotus hispidus is traditional Chinese medicine, which has been used to treat tumor illness for many years in China. However, the potential anti-tumor mechanisms of I. hispidus remain unclear.This study aimed to reveal the anti-tumor mechanism of I. hispidus petroleum ether extract (IPE) on H22 tumor-bearing mice from the point of view of metabonomics.The model of H22 tumor-bearing ...
DOI:
10.1016/j.jep.2021.114898

15. Anti-tumor effect of Yanggan Huayu granule by inducing AKT-mediated apoptosis in hepatocellular carcinoma

Author:
Yang Shen; Fan Yang; Haiyan Peng; Guangji Zhang; Fangfang Zhu; Haojun Xu; Le Shi
Source:
Journal of ethnopharmacology 2022 v.282 pp. 114601
ISSN:
0378-8741
Subject:
Oriental traditional medicine; Western blotting; antineoplastic activity; apoptosis; blood serum; cell growth; flow cytometry; hepatoma; mice; models; protein synthesis; xenotransplantation
Abstract:
... Yanggan Huayu granule (YGHY) is a formula of traditional Chinese medicine that has been widely used to treat patients with liver cancer. But its working mechanism is still poorly understood.Aim of the study: To investigate the anti-tumor effect of YGHY and its working mechanisms in hepatocellular carcinoma (HCC).H22 mouse xenograft model was used to detect the effect of YGHY on hepatocellular carc ...
DOI:
10.1016/j.jep.2021.114601

16. Antibacterial activity and cytotoxicity of sequentially extracted medicinal plant Blumea balsamifera Lin. (DC).

Author:
Ida Bagus Agung Yogeswara; I Gusti Ayu Wita Kusumawati; Ni Wayan Nursini
Source:
Biocatalysis and agricultural biotechnology 2022 v.43 pp. 102395
ISSN:
1878-8181
Subject:
Bacillus cereus; Blumea balsamifera; Escherichia coli O157; Pseudomonas aeruginosa; agricultural biotechnology; antibacterial properties; antineoplastic activity; bacterial infections; biocatalysis; cytotoxicity; dose response; ethyl acetate; hexane; human cell lines; medicinal plants; methanol; minimum inhibitory concentration; neoplasm cells; Asia
Abstract:
... Leaves of Blumea balsamifera Lin. (DC) is commonly used to treat bacterial infection and chronic diseases in Asia. This study determines the antibacterial activity and cytotoxicity of sequentially extracted hexane, ethyl acetate, and 50% aqueous methanol of B. balsamifera. B. balsamifera extracted with hexane (HE), ethyl acetate (HES) and 50% aqueous methanol (HEMS) showed significant inhibition ( ...
DOI:
10.1016/j.bcab.2022.102395

17. Anticancer Activity and Molecular Mechanism of Momordica cochinchinensis Seed Extract in Chronic Myeloid Leukemia Cells

Author:
Zhengdong Ai; Chong Ma; Ruiming Wan; Jingyi Yin; Guiming Li; Yan Li; Li Chen
Source:
Nutrition and cancer 2022 v.74 no.7 pp. 2644-2656
ISSN:
1532-7914
Subject:
Momordica cochinchinensis; antineoplastic activity; apoptosis; caspase-3; cell viability; fruits; interphase; mice; models; myeloid leukemia; nutrition; seed extracts; signal transduction; xenotransplantation
Abstract:
... Targeting Bcr-Abl is the key to the treatment of chronic myeloid leukemia. Despite great progress in the treatment of patients with chronic CML, advanced CML patients are still unable to obtain effective and safe drugs. Momordica cochinchinensis seed is the dried ripe seed of Momordica cochinchinensis, which is a kind of fruit and consumed for dietary as well as medicinal uses. This study aimed to ...
DOI:
10.1080/01635581.2021.2014904

18. Anticancer Effects of Combination of Indole-3-Carbinol and Hydroxychloroquine on Ehrlich Ascites Carcinoma via Targeting Autophagy and Apoptosis

Author:
Thoria Donia; Marian N Gerges; Tarek M Mohamed
Source:
Nutrition and cancer 2022 v.74 no.5 pp. 1802-1818
ISSN:
1532-7914
Subject:
Brassicaceae; antineoplastic activity; antineoplastic agents; apoptosis; ascites; autophagy; blood serum; body weight; carcinoma; caspase-3; females; gene expression; histopathology; mice; models; nutrition
Abstract:
... Indole-3-carbinol (I3C) is an active component of cruciferous vegetables which is considered a promising antineoplastic agent. This study aimed to assess I3C antineoplastic activity alone and with hydroxychloroquine (HCQ) on Ehrlich ascites carcinoma (EAC) model. Eighty female mice were divided into six groups wherein all groups except groups I and II received EAC cells (10⁶ cells/mouse i.p.). Gro ...
DOI:
10.1080/01635581.2021.1960388

19. Anticancer activity and apoptotic induction of Chromolaena odorata Linn leaves extract and fractions on hepatocellular carcinoma cell lines (HepG2)

Author:
HANIFAH YUSUF; MARHAMI FAHRIANI
Source:
Jurnal Natural (Aceh) 2022 v.22 no.1 pp. 57-67
ISSN:
2541-4062
Subject:
Chromolaena odorata; alkaloids; antineoplastic activity; apoptosis; ethanol; ethyl acetate; flavonoids; hepatoma; hexane; inhibitory concentration 50; liquid chromatography; maceration; neoplasm cells; saponins
Abstract:
... The purpose of this study is to screen and to evaluate anticancer activity and apoptosis induction of Chromolaena odorata (C. odorata) leaves extract and its fractions on HepG2 cancer cell lines. The C. odorata leaves were extracted by maceration using ethanol 80% then fractionated by using n-hexane, ethyl acetate and ethanol. MTT assay method was used to evaluate anticancer activity and flowcytom ...
DOI:
10.24815/jn.v22i1.22854

20. Anticancer activity of D-LAK-120A, an antimicrobial peptide, in non-small cell lung cancer (NSCLC)

Author:
Suyash M. Patil; Nitesh K. Kunda
Source:
Biochimie 2022 v.201 pp. 7-17
ISSN:
0300-9084
Subject:
DNA replication; antimicrobial peptides; antineoplastic activity; antineoplastic agents; apoptosis; cancer therapy; cell movement; cell proliferation; cytotoxicity; drug resistance; drug therapy; interphase; lactate dehydrogenase; lung neoplasms; membrane potential; mitochondrial membrane; neoplasm cells; propidium
Abstract:
... Non-small cell lung cancer (NSCLC) is a major cause of global cancer mortalities and accounts for approximately 80–85% of reported lung cancer cases. Conventional chemotherapeutics show limited application because of poor tumor selectivity and acquired drug resistance. Antimicrobial peptides (AMPs) have gained much attention as potential anticancer therapeutics owing to their high potency and high ...
DOI:
10.1016/j.biochi.2022.06.011

21. Anticancer activity of G4-targeting phenoxazine derivatives in vitro

Author:
Sofia A. Lizunova; Vladimir B. Tsvetkov; Dmitry A. Skvortsov; Polina N. Kamzeeva; Olga M. Ivanova; Lilja A. Vasilyeva; Alexey A. Chistov; Evgeny S. Belyaev; Alexei A. Khrulev; Tatiana S. Vedekhina; Alexandra N. Bogomazova; Maria A. Lagarkova; Anna M. Varizhuk; Andrey V. Aralov
Source:
Biochimie 2022 v.201 pp. 43-54
ISSN:
0300-9084
Subject:
adenocarcinoma; antineoplastic activity; biochemical pathways; breast neoplasms; fibroblasts; humans; kidneys; ligands; liver neoplasms; lungs; median effective concentration; nucleosides; promoter regions; telomeres; toxicity
Abstract:
... G4-stabilizing ligands are now being considered as anticancer, antiviral and antibacterial agents. Phenoxazine is a promising scaffold for the development of G4 ligands. Here, we profiled two known phenoxazine-based nucleoside analogs and five new nucleoside and non-nucleoside derivatives against G4 targets from telomere repeats and the KIT promoter region. Leading new derivatives exhibited remark ...
DOI:
10.1016/j.biochi.2022.07.001

22. Anticancer activity of IRAK‐4 inhibitors against canine lymphoid malignancies

Author:
Jun‐Hyeong Park; Jeong‐Hwa Lee; Ju‐Hyun An; Chong‐Woo Park; Yoon‐Pyo Choi; Seong‐Wook Seo; Hyuk‐Woo Lee; Hwa‐Young Youn
Source:
Veterinary and comparative oncology 2022 v.20 no.3 pp. 632-640
ISSN:
1476-5810
Subject:
B-cell lymphoma; B-lymphocytes; antineoplastic activity; apoptosis; cell viability; dogs; flow cytometry; humans; neoplasm cells; phosphorylation; polymerase chain reaction; veterinary medicine
Abstract:
... The interleukin‐1 receptor‐related kinase 4 (IRAK4), downstream of myd88, plays an essential role in hyperactive TLR signalling seen in some B‐cell lymphomas. In particular, efficient IRAK4 inhibitors of activated B‐cell subtype of human diffuse large B‐Cell lymphoma (DLBCL) are being developed. However, the anticancer effect of IRAK‐4 inhibitors in veterinary medicine has not been elucidated. It ...
DOI:
10.1111/vco.12816

23. Anticancer activity of Neosetophomone B by targeting AKT/SKP2/MTH1 axis in leukemic cells

Author:
Shilpa Kuttikrishnan; Ajaz A. Bhat; Jericha M. Mateo; Fareed Ahmad; Feras Q. Alali; Tamam El-Elimat; Nicholas H. Oberlies; Cedric J. Pearce; Shahab Uddin
Source:
Biochemical and biophysical research communications 2022 v.601 pp. 59-64
ISSN:
0006-291X
Subject:
antineoplastic activity; apoptosis; caspases; cell viability; fungi; leukemia; meroterpenoids; mitochondria; oncogenes; pro-apoptotic proteins; research; secondary metabolites; therapeutics
Abstract:
... Neosetophomone B (NSP–B), a meroterpenoid fungal secondary metabolite, was investigated for its anticancer potential in leukemic cell lines (K562 and U937). NSP-B treatment of leukemic cells suppressed cell viability by triggering apoptotic cell death. Apoptosis induced by NSP-B is triggered by mitochondrial signaling and caspase activation. Additionally, NSP-B treatment of leukemic cells causes A ...
DOI:
10.1016/j.bbrc.2022.02.071

24. Anticancer activity of Terminalia chebula, Terminalia bellirica, and Phyllanthus emblica extracts on cholangiocarcinoma cell proliferation and induction of apoptosis

Author:
Phannipha Chekdaengphanao; Dareena Jaiseri; Pranee Sriraj; Ratchadawan Aukkanimart; Jatupron Prathumtet; Patwarapohn Udonsan; Thidarut Boonmars
Source:
Journal of herbal medicine 2022 v.35 pp. 100582
ISSN:
2210-8033
Subject:
Phyllanthus emblica; Terminalia bellirica; Terminalia chebula; antineoplastic activity; apoptosis; caspase-3; caspase-9; cell cycle checkpoints; cell proliferation; cytotoxicity; drug therapy; flavonoids; gene expression; herbal medicines; inflammation; interphase; mitochondria; neoplasms; tannins; Thailand
Abstract:
... Cholangiocarcinoma (CCA) has a low incidence universally, but very high incidence in the northeast of Thailand. Currently, the treatments of CCA are ineffective. Therefore, substances from natural products have been developed to replace by reducing the toxicity of chemotherapy drugs. Therefore, this study evaluated the effects of Terminalia chebula, Terminalia bellirica, and Phyllanthus emblica ex ...
DOI:
10.1016/j.hermed.2022.100582

25. Anticancer activity of chicken cathelicidin peptides against different types of cancer

Author:
Maged Mostafa Mahmoud; Modhi Alenezi; Ahmed M. Al-Hejin; Turki S. Abujamel; Fadwa Aljoud; Abdulwahab Noorwali; Ibrahim A. Awad; Mohammed Alkhaled; Haitham A. Yacoub
Source:
Molecular biology reports 2022 v.49 no.6 pp. 4321-4339
ISSN:
0301-4851
Subject:
antineoplastic activity; antineoplastic agents; ascites; breast neoplasms; caspase-3; cathelicidins; chickens; colorectal neoplasms; cyclins; humans; immunohistochemistry; mechanism of action; models; molecular biology; necrosis; neoplasm cells
Abstract:
... BACKGROUND: This study served as the pioneer in studying the anti-cancer role of chicken cathelicidin peptides. METHODS AND RESULTS: Chicken cathelicidins were used as anticancer agent against the breast cancer cell line (MCF-7) and human colon cancer cell line (HCT116). In addition, the mechanism of action of the interaction of cationic peptides with breast cancer cell line MCF-7 was also investi ...
DOI:
10.1007/s11033-022-07267-7

26. Anticancer effects of imidazole nucleus in hepatocellular carcinoma cell lines via the inhibition of AKT and ERK1/2 signaling pathways

Author:
Erkan Kahraman; Erdem Göker
Source:
Molecular biology reports 2022 v.49 no.6 pp. 4377-4388
ISSN:
0301-4851
Subject:
Western blotting; antineoplastic activity; apoptosis; autophagy; cancer therapy; caspase-3; cell culture; cell movement; cell structures; cell viability; drugs; hepatoma; imidazole; molecular biology; neoplasm cells; viability assays
Abstract:
... BACKGROUND: Imidazole nucleus has been used efficiently in the development of many drug molecules due to its therapeutic effects. Many derivatives of it have been produced particularly for use in cancer treatment. However, the anti-cancer effects of imidazole nucleus in liver cancer cells are as yet unclear. In this study, we aimed to investigate the anti-cancer effects of imidazole nucleus in hep ...
DOI:
10.1007/s11033-022-07273-9

27. Anticancer effects of picrasidine I on oral squamous cell carcinoma

Author:
Yuan‐Ting Yang; Ming‐Ju Hsieh; Yi‐Ching Chuang; Chia‐Chieh Lin; Yu‐Sheng Lo; Hsin‐Yu Ho; V. Bharath Kumar; Jiunn‐Liang Ko
Source:
Environmental toxicology 2022 v.37 no.3 pp. 627-636
ISSN:
1520-4081
Subject:
Picrasma quassioides; alkaloids; antineoplastic activity; antineoplastic agents; apoptosis; caspases; cell viability; cyclins; cytotoxicity; death; dose response; ecotoxicology; membrane potential; mitochondrial membrane; mouth neoplasms; phosphorylation; squamous cell carcinoma; therapeutics
Abstract:
... Picrasidine I is a dimeric alkaloid derived from a Southern Asian plant Picrasma quassioides and demonstrated to possess pharmacological activities, such as anti‐inflammatory and anti‐osteoclastogenic effects. However, its potential anticancer effect remains unclear. In the present study, anticancer activity of picrasidine I was assessed by treating oral squamous cell carcinoma cells with differen ...
DOI:
10.1002/tox.23430

28. Antioxidant and Anticancer Effects of Epsilon-Poly-L-lysine Produced by Two Novel Strains of Paenibacillus polymyxa HS6 and Stenotrophomonas maltophilia YS8

Author:
Hamidreza Hagh Ranjbar; Afrouzossadat Hosseini Abari; Seyed Mahdi Ghasemi; Najmeh Ghorbani
Source:
Biotechnology and bioprocess engineering 2022 v.27 no.4 pp. 586-595
ISSN:
1226-8372
Subject:
Fourier transform infrared spectroscopy; Paenibacillus polymyxa; Stenotrophomonas maltophilia; antineoplastic activity; antioxidant activity; antioxidants; bioactive compounds; bioprocessing; biotechnology; chemical precipitation; cytotoxicity; flow cytometry; high performance liquid chromatography; nucleotide sequences; polyacrylamide gel electrophoresis; polypeptides; sequence analysis; sodium; soil; thiazolyl blue
Abstract:
... Epsilon-Poly-L-lysine (ε-PL) is a non-toxic cationic homopolypeptide with unique bioactive properties. In this study, two novel polylysine producers, Paenibacillus polymyxa HS6 and Stenotrophomonas maltophilia YS8 were isolated from different soil samples and identified by 16S rDNA sequence analysis. To obtain pure cationic polypeptide from these bacteria, chemical precipitation with sodium tetrap ...
DOI:
10.1007/s12257-022-0065-1

29. Antioxidant and anticancer activities of Annona muricata L. and Antidesma bunius L. leaves, and molecular networking analysis using LC-MS/MS metabolomics

Author:
Aya Gabriella Peña; Michael Russelle Alvarez; Kimberly Delica; Patrick Gabriel Moreno; Rowell Abogado; Sheryl Joyce Grijaldo; Edcyl Lee Salac; Froila Marie Deniega; Manolo Basingan; Cherry Mae Ravidas; Francisco Heralde; Gladys Cherisse Completo; Isagani Padolina; Ruel Nacario
Source:
South African journal of botany 2022 pp. -
ISSN:
0254-6299
Subject:
Annona muricata; Antidesma bunius; Philippines; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; chlorophyll; ethyl acetate; growth retardation; hexane; humans; indoles; leaves; lung neoplasms; metabolomics; methanol; phytochemicals; toxicity testing
Abstract:
... Several natural products are known to have anticancer activity, which helps prevent cancer. This study explores the potential use of different extracts of Annona muricata L. and Antidesma bunius L. leaves as an anticancer drug by testing its anti-oxidative and anticancer properties. Furthermore, metabolomics of these plant extracts was performed to characterize them. This project studied the bioac ...
DOI:
10.1016/j.sajb.2022.06.019

30. Antiproliferative effects and main molecular mechanisms of Brazilian native fruits and their by-products on lung cancer

Author:
Ana Paula da Fonseca Machado; Mariana da Rocha Alves; Roberto de Paula do Nascimento; Lívia Mateus Reguengo; Mario Roberto Marostica Junior
Source:
Food research international 2022 v.162 pp. 111953
ISSN:
0963-9969
Subject:
Bixa orellana; Caryocar brasiliense; Myrciaria dubia; Paullinia cupana; Plinia cauliflora; antineoplastic activity; apoptosis; biodiversity; carcinogenesis; cell cycle; cell viability; emerging diseases; evolution; food research; lung neoplasms; lungs; neoplasm cells; risk; Brazil
Abstract:
... Lung Cancer (LC) is an emergent disease widespread globally. Compared to other types of cancer, LC has one of the lowest survival rates (18%). As some risk factors associated with the development of lung carcinogenesis are still unavoidable, researchers have been trying to find efficient and safe alternatives that can help prevent LC or even attenuate its rapid evolution after diagnosis. Studies w ...
DOI:
10.1016/j.foodres.2022.111953

31. Antitumor Effect of Manool in a Murine Melanoma Model

Author:
Heloiza Diniz Nicolella; Arthur Barcelos Ribeiro; Matheus Reis Santos de Melo; Saulo Duarte Ozelin; Lucas Henrique Domingos da Silva; Rodrigo Cássio Sola Veneziani; Denise Crispim Tavares
Source:
Journal of natural products 2022 v.85 no.2 pp. 426-432
ISSN:
1520-6025
Subject:
Salvia officinalis; antineoplastic activity; caspase-3; cisplatin; cytotoxicity; diterpenoids; melanoma; mice; mitosis; models
Abstract:
... The manool diterpene, found in abundance in Salvia officinalis L., showed a selective cytotoxic effect against murine melanoma cells. Therefore, the present study aimed to evaluate the antitumor potential of manool in a murine melanoma model, administered by three routes: oral, subcutaneous, and intraperitoneal. In addition, the antimelanoma effect of manool (orally) combined with cisplatin (subcu ...
DOI:
10.1021/acs.jnatprod.1c01128

32. Antitumor Potential of Withanolide Glycosides from Ashwagandha (Withania somnifera) on Apoptosis of Human Hepatocellular Carcinoma Cells and Tube Formation in Human Umbilical Vein Endothelial Cells

Author:
Dahae Lee; Jae Sik Yu; Ji Won Ha; Seoung Rak Lee; Bum Soo Lee; Jin-Chul Kim; Jung Kyu Kim; Ki Sung Kang; Ki Hyun Kim
Source:
Antioxidants 2022 v.11 no.9 pp. -
ISSN:
2076-3921
Subject:
B-cell lymphoma; Withania somnifera; antineoplastic activity; apoptosis; blood; cancer therapy; caspase-3; caspase-8; caspase-9; cell viability; circular dichroism spectroscopy; cytotoxicity; electrospray ionization mass spectrometry; enzymatic hydrolysis; fractionation; glycosides; hepatoma; humans; liquid chromatography; liver; longevity; medicinal plants; metabolites; mitogen-activated protein kinase; nuclear magnetic resonance spectroscopy; phosphatidylinositol 3-kinase; phytochemicals; protein synthesis; rapamycin; vascular endothelial growth factor receptor-2
Abstract:
... Hepatocellular carcinoma (HCC) is the fastest-growing tumor capable of spreading to other organs via blood vessels formed by endothelial cells. Apoptosis and angiogenesis-targeting therapies are attractive for cancer treatment. In this study, we aimed to study the in vitro cytotoxicity of Withania somnifera against human HCC (HepG2) cells, identify potential antitumoral withanolide glycosides from ...
DOI:
10.3390/antiox11091761

33. Antitumor activity of Tigerinin-1: Necroptosis mediates toxicity in A549 cells

Author:
Anet Antony; Shilpa Olakkaran; Anupama Kizhakke Purayil; Shamasoddin Shekh; Konkallu Hanumae Gowd; Hunasanahally Puttaswamygowda Gurushankara
Source:
Biochimica et biophysica acta 2022 v.1866 no.9 pp. 130182
ISSN:
0304-4165
Subject:
Hoplobatrachus tigerinus; angiogenesis; antimicrobial peptides; antineoplastic activity; cell membranes; cell proliferation; chemistry; cytotoxicity; fibroblast growth factors; genotoxicity; humans; lysosomes; necroptosis; necrosis; neoplasm cells; reactive oxygen species; therapeutics; vascular endothelial growth factor receptor-2; vascular endothelial growth factors
Abstract:
... Tigerinins are antimicrobial peptides (AMPs) derived from the skin secretions of the Indian bullfrog Hoplobatrachus tigerinus. Tigerinin-1 (FCTMIPIPRCY-Am) peptide was synthesized by solid-phase Fmoc chemistry and investigated its antitumor activities. Tigerinin-1 was cytotoxic to human cancer cells. It causes necrosis by damaging the cell membrane and loss of lysosome integrity. Tigerinin-1trigge ...
DOI:
10.1016/j.bbagen.2022.130182

34. Antitumor and Immunomodulatory Properties of the Bulgarian Endemic Plant Betonica bulgarica Degen et Neič. (Lamiaceae)

Author:
Tsvetelina Mladenova; Tsvetelina Batsalova; Balik Dzhambazov; Rumen Mladenov; Ivanka Teneva; Plamen Stoyanov; Anelia Bivolarska
Source:
Plants 2022 v.11 no.13 pp. -
ISSN:
2223-7747
Subject:
Betonica; adenocarcinoma; antineoplastic activity; apoptosis; culture media; cytotoxicity; flow cytometry; humans; immunomodulators; indigenous species; lungs; mice; plant extracts
Abstract:
... Background: Extracts obtained from different Betonica species have been shown to possess important biological properties. The present study aimed to investigate the cytotoxicity, antitumor and immunomodulatory potential of the endemic plant Betonica bulgarica (Lamiaceae) and thus, reveal new aspects of its biological activity. Methods: Methanolic extract obtained from inflorescences was analyzed f ...
DOI:
10.3390/plants11131689

35. Antitumor and hepatoprotective effect of Cuscuta reflexa Roxb. in a murine model of colon cancer

Author:
Shobhit Mishra; Fahad Saad Alhodieb; Md. Abul Barkat; Mohd. Zaheen Hassan; Harshita Abul Barkat; Raisuddin Ali; Perwaiz Alam; Ozair Alam
Source:
Journal of ethnopharmacology 2022 v.282 pp. 114597
ISSN:
0378-8741
Subject:
Cuscuta reflexa; X-radiation; acute oral toxicity; analgesics; animal models; anthelmintics; antineoplastic activity; apoptosis; barium; cell proliferation; colon; colonoscopy; colorectal neoplasms; erythrocytes; fluorouracil; hemoglobin; hepatoprotective effect; histology; histopathology; hydrazine; mitosis; neoplasm progression; neutrophils; traditional medicine
Abstract:
... Cuscuta reflexa Roxb. (C. reflexa) is a well-known traditional herbal plant, with numerous inherent therapeutic potentials including anticancer, antitumor, antibacterial, analgesic, anthelmintic, laxative and others. Moreover, the anticancer and antitumor potentials of this herb are ongoing with several trails, thus an attempt was made to assess the anticancer and hepatoprotective potentials of tr ...
DOI:
10.1016/j.jep.2021.114597

36. Anti‐breast‐cancer activity of self‐fermented Bovistella sinensis Lloyd extracts through the mitochondrial ROS‐induced apoptosis in vitro

Author:
Qinghua Zeng; Ragini Singh; Yong Ye; Shuang Cheng; Feng Kong; Qingmei Zeng
Source:
Journal of food biochemistry 2022 v.46 no.9 pp. e14218
ISSN:
0145-8884
Subject:
anticarcinogenic agents; antineoplastic activity; apoptosis; breast neoplasms; butanol; cell lines; cytotoxicity; ethanol; ethyl acetate; fatty acids; functional foods; ingredients; membrane potential; mitochondria; mitochondrial membrane; neoplasm cells; petroleum; reactive oxygen species
Abstract:
... Bovistella sinensis (BS) Lloyd was medically used by Chinese folks and associated with various bioactivities. In this study, dry fruiting body of Bovistella sinensis (BS) Lloyd was self‐fermented to improve the anti‐breast‐cancer activity and the mitochondrial ROS‐induced apoptosis of key compound was investigated. BS extracts obtained with petroleum ether, ethyl acetate, n‐butanol, ethanol, and d ...
DOI:
10.1111/jfbc.14218

37. Apoptosis-Sensing Xenograft Zebrafish Tumor Model for Anticancer Evaluation of Redox-Responsive Cross-Linked Pluronic Micelles

Author:
Jinsong Tao; Zhengjie Wei; Yaxin Cheng; Meng Xu; Qiuxia Li; Simon Ming-Yuen Lee; Wei Ge; Kathy Qian Luo; Xueqing Wang; Ying Zheng
Source:
ACS applied materials & interfaces 2022 v.14 no.35 pp. 39775-39786
ISSN:
1944-8252
Subject:
Danio rerio; angiogenesis; animal models; antineoplastic activity; apoptosis; cancer therapy; crosslinking; doxorubicin; glutathione; micelles; nanomedicine; neoplasms; polymers; xenotransplantation
Abstract:
... A suitable animal model for preclinical screening and evaluation in vivo could vastly increase the efficiency and success rate of nanomedicine development. Compared with rodents, the transparency of the zebrafish model offers unique advantages of real-time and high-resolution imaging of the whole body and cellular levels in vivo. In this research, we established an apoptosis-sensing xenograft zebr ...
DOI:
10.1021/acsami.2c09005

38. Application of ultrasound‐assisted enzymatic extraction to enhance triterpenoid content and the biological properties of Vietnamese Ganoderma lucidum extract

Author:
Tran Do Dat; Nguyen Phan Thi Cam Chuong; Nguyen Minh Anh; Nguyen Duc Viet; Vuong Hoai Thanh; Nguyen Huynh Bach Son Long; Huynh Ngoc Oanh; Hoang Minh Nam; Mai Thanh Phong; Nguyen Huu Hieu
Source:
Journal of food processing and preservation 2022 v.46 no.7 pp. e16635
ISSN:
0145-8892
Subject:
Escherichia coli; Fourier transform infrared spectroscopy; Ganoderma lucidum; Pseudomonas aeruginosa; Salmonella enterica; Staphylococcus aureus; antibacterial properties; antineoplastic activity; breast neoplasms; cancer therapy; carcinoma; enzymes; ethanol; experimental design; functional foods; gas chromatography-mass spectrometry; health promotion; hepatoma; maceration; models; phytochemicals; temperature; toxicity testing; triterpenoids; ultrasonic treatment; ultrasonics
Abstract:
... The ultrasound‐assisted enzymatic extraction (UAEE) in this work was utilized to extract triterpenoid from Ganoderma lucidum (G. lucidum). The enzyme concentration (%), ethanol: material ratio (ml/g), ultrasonic duration (min), ultrasonic temperature (°C), and ultrasonic power (W) were all studied as factors impacting triterpenoid content. The experiment was developed using the Plackett–Burman mod ...
DOI:
10.1111/jfpp.16635

39. Applications of lipid-engineered nanoplatforms in the delivery of various cancer therapeutics to surmount breast cancer

Author:
Ujala Gupta; Brojendra Nath Saren; Kedar Khaparkhuntikar; Jitender Madan; Pankaj Kumar Singh
Source:
Journal of controlled release 2022 v.348 pp. 1089-1115
ISSN:
0168-3659
Subject:
antineoplastic activity; apoptosis; bioavailability; breast neoplasms; breasts; cell viability; cost effectiveness; drug therapy; half life; nanocarriers; peptides; relapse; toxicity
Abstract:
... Breast cancer (BC) is the most extensively accounted malignancy among the women across the globe and is treatable in 70–80% of patients with early-stage, non-metastatic cancer. The current available therapies have been found to be less effective to treat distant organ metastases and advanced breast cancers. The clinical efficacy hugely suffers from chemoresistance, non-specific toxicity, relapse a ...
DOI:
10.1016/j.jconrel.2022.05.034

40. Aqueous extract of Solanum nigrum attenuates Angiotensin-II induced cardiac hypertrophy and improves cardiac function by repressing protein kinase C-ζ to restore HSF2 deSUMOlyation and Mel-18-IGF-IIR signaling suppression

Author:
Hung-Jen Lin; Ramasamy Mahendran; Hsiang-Yen Huang; Ping-Ling Chiu; Yung-Ming Chang; Cecilia Hsuan Day; Ray-Jade Chen; V. Vijaya Padma; Yang Liang-Yo; Wei-Wen Kuo; Chih-Yang Huang
Source:
Journal of ethnopharmacology 2022 v.284 pp. 114728
ISSN:
0378-8741
Subject:
Solanum nigrum; actin; angiotensin II; antineoplastic activity; cardiac output; cardioprotective effect; diarrhea; dose response; eyes; fever; fluorescent antibody technique; glycoproteins; heart; heart failure; hypertrophy; liver; males; psoriasis; ringworm; steroid alkaloids; steroid saponins; traditional medicine
Abstract:
... Solanum nigrum, commonly known as Makoi or black shade has been traditionally used in Asian countries and other regions of world to treat liver disorders, diarrhoea, inflammatory conditions, chronic skin ailments (psoriasis and ringworm), fever, hydrophobia, painful periods, eye diseases, etc. It has been observed that S. nigrum contains substances, like steroidal saponins, total alkaloid, steroid ...
DOI:
10.1016/j.jep.2021.114728

41. Aqueous two-phase extraction of polysaccharides from Selaginella doederleinii and their bioactivity study

Author:
Gang Li; Xiankui Ma; Yongmei Jiang; Weiwei Li; Yongling Wang; Li Liu; Chengxin Sun; Shiji Xiao; Jie Lan; Juxiang Kuang; Gang Wang
Source:
Process biochemistry 2022 v.118 pp. 274-282
ISSN:
1359-5113
Subject:
Selaginella doederleinii; antineoplastic activity; antioxidant activity; antioxidants; ethanol; liquids; polysaccharides; salt concentration; thermogravimetry; ultrasonics
Abstract:
... In this study, the ethanol/salt aqueous two-phase system was firstly used to extract Selaginella doederleinii polysaccharides (SDP). Through single factor and response surface analysis, the best extraction conditions were as follows: extraction time of 40 min, ultrasonic power of 280 W, ethanol concentration of 35%, inorganic salt concentration of 0.22 g/mL, and liquid/solid ratio of 25 mL/g with ...
DOI:
10.1016/j.procbio.2022.04.024

42. Arborinine suppresses ovarian cancer development through inhibition of LSD1

Author:
Nan Li; Liang Yang; Hongling Zuo
Source:
Life sciences 2022 v.291 pp. 120275
ISSN:
0024-3205
Subject:
Western blotting; antineoplastic activity; antineoplastic agents; cancer therapy; carcinogenesis; cell lines; cell movement; cell proliferation; cytotoxicity; dose response; drug therapy; epithelium; females; gene expression; mice; neoplasm cells; ovarian neoplasms; paclitaxel; toxicity testing
Abstract:
... Epithelial ovarian carcinoma is the most lethal female reproductive malignancy in the world. Paclitaxel and carboplatin are generally the first-line treatment drugs for ovarian cancer patients, but numerous patients may develop chemotherapy resistance. Thus, it is urgent to identify novel drugs for ovarian cancer treatment. Arborinine has been known as a broad-spectrum anti-tumor agent due to it p ...
DOI:
10.1016/j.lfs.2021.120275

43. Artificial Diets Based on Selective Amino Acid Restriction versus Capecitabine in Mice with Metastatic Colon Cancer

Author:
Julio José Jiménez-Alonso; Emilio Guillén-Mancina; José Manuel Calderón-Montaño; Víctor Jiménez-González; Patricia Díaz-Ortega; Estefanía Burgos-Morón; Miguel López-Lázaro
Source:
Nutrients 2022 v.14 no.16 pp. -
ISSN:
2072-6643
Subject:
antineoplastic activity; casein; caudal vein; colorectal neoplasms; cysteine; glutamine; leucine; metabolism; metastasis; mice; peritoneum; therapeutics
Abstract:
... New therapies are needed to improve the low survival rates of patients with metastatic colon cancer. Evidence suggests that amino acid (AA) restriction can be used to target the altered metabolism of cancer cells. In this work, we evaluated the therapeutic potential of selective AA restriction in colon cancer. After observing anticancer activity in vitro, we prepared several artificial diets and e ...
DOI:
10.3390/nu14163378

44. Assessment of antioxidant, antimicrobial, and anticancer activities of Sisymbrium officinale plant extract

Author:
Mahmoud Khalid; Mousa Amayreh; Saadi Sanduka; Zaidoun Salah; Fuad Al-Rimawi; Ghassab M. Al-Mazaideh; Abdulkareem A. Alanezi; Fadel Wedian; Fawaz Alasmari; Mohammed Helmy Faris Shalayel
Source:
Heliyon 2022 v.8 no.9 pp. e10477
ISSN:
2405-8440
Subject:
Escherichia coli; Gram-negative bacteria; Sisymbrium officinale; Staphylococcus; Streptococcus; air drying; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; breast neoplasms; breasts; cell lines; colon; ethanol; flavonoids; markets; neoplasm cells; plant extracts; ultrasonic treatment
Abstract:
... The most efficient and safe source of medications is the natural and traditional medications which are produced from plants and herbs. In this study, Sisymbrium officinale (S. officinale) was tested to explore its total phenolic and flavonoids contents. Antioxidant, antimicrobial, and anticancer activities were assessed as well. S. officinale was bought from a local Palestinian market, air-dried, ...
DOI:
10.1016/j.heliyon.2022.e10477

45. Assessment of the anti-tumor activity of cyanidin-3-O-arabinoside from apple against APN, JAK, and EZH2 target proteins

Author:
Dan Zhang; Zhipeng Yu; Wenzhu Zhao; Jingbo Liu
Source:
Food bioscience 2022 v.48 pp. 101788
ISSN:
2212-4292
Subject:
antineoplastic activity; apoptosis; apples; colon; colorectal neoplasms; humans; interphase; membrane alanyl aminopeptidase; non-specific protein-tyrosine kinase; polyphenols
Abstract:
... This study aimed to evaluate the anti-tumor activity and the mechanism of apple polyphenols on aminopeptidase N (APN), janus kinase 3 (JAK3) and enhancer of zeste homolog 2 (EZH2) using molecular docking and in vitro human colon (Caco-2) cells. The 88 apple polyphenols were docked with targets, i.e., APN, JAK3, and EZH2, and the potential polyphenol cyanidin-3-O-arabinoside was selected. CCK-8 ass ...
DOI:
10.1016/j.fbio.2022.101788

46. Astragalus polysaccharide: a review of its immunomodulatory effect

Author:
Chun-xiao Li; Ying Liu; Yu-zhen Zhang; Jing-chun Li; Jiang Lai
Source:
Archives of pharmacal research 2022 v.45 no.6 pp. 367-389
ISSN:
0253-6269
Subject:
Astragalus membranaceus; antineoplastic activity; asthma; autoimmune diseases; bioactive compounds; bone marrow; chemokines; immunomodulators; insulin-dependent diabetes mellitus; lymph; macrophages; medicine; neuroglia; polysaccharides; research; spleen
Abstract:
... The Astragalus polysaccharide is an important bioactive component derived from the dry root of Astragalus membranaceus. This review aims to provide a comprehensive overview of the research progress on the immunomodulatory effect of Astragalus polysaccharide and provide valuable reference information. We review the immunomodulatory effect of Astragalus polysaccharide on central and peripheral immun ...
DOI:
10.1007/s12272-022-01393-3

47. Asymmetric Total Synthesis of (−)-Phaeocaulisin A

Author:
Áron Péter; Giacomo E. M. Crisenza; David J. Procter
Source:
Journal of the American Chemical Society 2022 v.144 no.16 pp. 7457-7464
ISSN:
1520-5126
Subject:
Curcuma phaeocaulis; antineoplastic activity; chemoselectivity; drug design; enantioselectivity; ginger; isomers; moieties; reducing agents; samarium; sesquiterpenoids; therapeutics; traditional medicine; turmeric
Abstract:
... The therapeutic properties of Curcuma (ginger and turmeric’s family) have long been known in traditional medicine. However, only recently have guaiane-type sesquiterpenes extracted from Curcuma phaeocaulis been submitted to biological testing, and their enhanced bioactivity was highlighted. Among these compounds, phaeocaulisin A has shown remarkable anti-inflammatory and anticancer activity, which ...
DOI:
10.1021/jacs.2c02188

48. Ataxia-telangiectasia mutated and ataxia telangiectasia and Rad3-related kinases as therapeutic targets and stratification indicators for prostate cancer

Author:
Chloe Gulliver; Ralf Hoffmann; George S. Baillie
Source:
international journal of biochemistry & cell biology 2022 v.147 pp. 106230
ISSN:
1357-2725
Subject:
DNA; DNA damage; antineoplastic activity; biomarkers; cell death; drug development; drug resistance; drug therapy; genomics; medicine; metastasis; mutants; phenotype; phosphotransferases (kinases); prognosis; prostatic neoplasms; relapse
Abstract:
... The DNA damage response is an integral part of a cells’ ability to maintain genomic integrity by responding to and ameliorating DNA damage, or initiating cell death for irrepairably damaged cells. This response is often hijacked by cancer cells to evade cell death allowing mutant cells to persist, as well as in the development of treatment resistance to DNA damaging agents such as chemotherapy and ...
DOI:
10.1016/j.biocel.2022.106230

49. Auriculasin enhances ROS generation to regulate colorectal cancer cell apoptosis, ferroptosis, oxeiptosis, invasion and colony formation

Author:
Chun-xiao Wang; Li-hua Chen; Hai-bin Zhuang; Ze-sheng Shi; Zhi chuan Chen; Jian-peng Pan; Zhong-shi Hong
Source:
Biochemical and biophysical research communications 2022 v.587 pp. 99-106
ISSN:
0006-291X
Subject:
Flemingia; antineoplastic activity; apoptosis; cell viability; colorectal neoplasms; digestive system; ferroptosis; herbal medicines; mitochondria; neoplasm cells; phosphorylation; reactive oxygen species; research; shrinkage
Abstract:
... Colorectal cancer (CRC) is one of the most common malignant tumors in the digestive system, and Chinese herbal medicine plays an important role in tumor treatment. The in-depth study of auriculasin isolated from Flemingia philippinensis showed that auriculasin promoted reactive oxygen species (ROS) generation in a concentration-dependent manner; when ROS scavenger NAC was added, the effects of aur ...
DOI:
10.1016/j.bbrc.2021.11.101

50. Azadirachta indica A. Juss Fruit Mesocarp and Epicarp Extracts Induce Antimicrobial and Antiproliferative Effects against Prostate (PC-3), Breast (MCF-7), and Colorectal Adenocarcinoma (Caco-2) Cancer Cell Lines through Upregulation of Proapoptotic Genes

Author:
Omer H. M. Ibrahim; Magdi A. A. Mousa; Khalid A. Asiry; Nabil A. Alhakamy; Kamal A. M. Abo-Elyousr
Source:
Plants 2022 v.11 no.15 pp. -
ISSN:
2223-7747
Subject:
Azadirachta indica; adenocarcinoma; antineoplastic activity; apoptosis; breasts; cell cycle checkpoints; chemical composition; cytotoxicity; dose response; exocarp; fruit extracts; genes; mesocarp; neoplasm cells; therapeutics
Abstract:
... Effective alternative strategies and methodological approaches are critically necessary for cancer prevention and therapy. In this study, we investigated the antitumor potential of neem fruit mesocarp and epicarp extracts. The chemical composition of the derived extracts was characterized using GC–MS. Data were collected on the antimicrobial activity of the extracts in addition to the cytotoxicity ...
DOI:
10.3390/plants11151990