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1. Construction of a novel blood brain barrier-glioma microfluidic chip model: Applications in the evaluation of permeability and anti-glioma activity of traditional Chinese medicine components

Author:
Yiwei Shi; Xiaoli He; Hui Wang; Jianying Dai; Jiahao Fang; Yuzhen He; Xiaofei Chen; Zhanying Hong; Yifeng Chai
Source:
Talanta 2023 v.253 pp. 123971
ISSN:
0039-9140
Subject:
Oriental traditional medicine; antineoplastic agents; astrocytes; blood; blood-brain barrier; brain; fluorescein; glioma; high performance liquid chromatography; humans; isothiocyanates; models; organ-on-a-chip; permeability
Abstract:
... Since most anti-glioma drug candidates hardly permeate through the blood-brain barrier (BBB), preclinical models that can integrate the complexity of the tumor microenvironment and the structure and function of the BBB is urgently needed for the treatment of glioma. Herein, we constructed an in vitro BBB-glioma microfluidic chip model lined by primary human brain microvascular endothelial cells, p ...
DOI:
10.1016/j.talanta.2022.123971

2. Fresh Brassicaceae sprouting broccoli (Bimi®) glucosinolates profile characterization and bioaccessibility through an in vitro dynamic digestion study

Author:
Juan Antonio Nieto; Pilar Hellín; Beatriz Pérez; Blanca Viadel; Alberto Alapont; Agatha Agudelo
Source:
Journal of food composition and analysis 2023 v.115 pp. 104941
ISSN:
0889-1575
Subject:
Brassicaceae; antineoplastic agents; bioavailability; broccoli; digestion; food composition; gastrointestinal system; glucobrassicin; gluconapin; glucoraphanin; isothiocyanates; progoitrin
Abstract:
... Bimi® (Brassica oleracea Italica x Alboglabra) glucosinolate content was determined as 83.64 mg/100 g of fresh sample, mainly characterised by aliphatic (61 %) and indolic (39 %) glucosinolates. Glucoraphanin was the main compound (36.75 ± 1.96 mg/100 g) followed by glucosbrassicin (22.46 ± 6.37 mg/100 g) and progoitrin (11.95 ± 1.31 mg/100 g). Other remarkable compounds were neoglucobrassicin, 4- ...
DOI:
10.1016/j.jfca.2022.104941

3. Genome-wide profiling of dysregulated piRNAs and their target genes implicated in oncogenicity of tongue squamous cell carcinoma

Author:
Trisha Chattopadhyay; Pooja Gupta; Rojalin Nayak; Bibekanand Mallick
Source:
Gene 2023 v.849 pp. 146919
ISSN:
0378-1119
Subject:
RNA; antineoplastic agents; carcinogenesis; carcinogenicity; databases; gene expression; genes; geranylgeranyl diphosphate synthase; germ cells; mouth neoplasms; squamous cell carcinoma; tongue; transcriptome
Abstract:
... PIWI-interacting RNAs (piRNAs) are single-stranded, 23–36 nucleotide long RNAs that regulate gene expression in the germline but are also detected in some cancers. However, there are no reports yet on piRNA expression in tongue squamous cell carcinoma (TSCC), the most common oral cancer (80–90% percent of all oral cancers). We performed small RNA and whole transcriptome sequencing in H357 tongue c ...
DOI:
10.1016/j.gene.2022.146919

4. Tongguanteng injection reverses paclitaxel resistance via upregulation of TAB1 expression in ovarian cancer in vitro and in vivo

Author:
Qian-Wen Kong; Jiao Yang; Dan Li; Ya-Wei Ding; Yu-Jie Hu; Xiao-Chuan Xue; Mei-Zhi Shi; Bo Jiang; Yang-Yun Zhou; Min Zhang; Jiu-Dong Hu; Cheng Guo; Jun-Jun Chen; Yong-Long Han
Source:
Journal of ethnopharmacology 2023 v.300 pp. 115728
ISSN:
0378-8741
Subject:
Marsdenia tenacissima; adjuvants; antineoplastic agents; apoptosis; bioinformatics; carcinogenesis; drug therapy; flow cytometry; gene expression; histopathology; humans; immunohistochemistry; models; ovarian neoplasms; paclitaxel; plasmids; prognosis; proteomics; synergism; traditional medicine; xenotransplantation
Abstract:
... Tongguanteng injection (TGT), the water extract from the stem of the Traditional Chinese hebal medicine of Marsdenia tenacissima (Roxb.) Wight et Arn. has been used as anticancer remedy for decades. TGT was not only used in the treatment of many malignant cancers extensively, but also an adjuvant anticancer drug with chemotherapeutics clinically. To evaluate the effects of TGT on reversing paclita ...
DOI:
10.1016/j.jep.2022.115728

5. A hybrid metal-organic framework nanomedicine-mediated photodynamic therapy and hypoxia-activated cancer chemotherapy

Author:
Zhen Jia; Yong Gao; Jiali Ni; Xiaochang Wu; Zhengwei Mao; Guoping Sheng; Yuefeng Zhu
Source:
Journal of colloid and interface science 2023 v.629 pp. 379-390
ISSN:
0021-9797
Subject:
antineoplastic agents; blood; blood circulation; coordination polymers; hybridization; hypoxia; immunotherapy; nanogold; nanomedicine; neoplasms; pharmacokinetics; phosphates; photochemotherapy; polyethylene glycol; porphyrins
Abstract:
... The hypoxic tumor microenvironment and photodynamic therapy (PDT)-aggravated hypoxia compromise the anticancer efficacy of chemotherapy, immunotherapy, and PDT. Thus, sophisticated nanomedicines that can activate their anticancer capability in situ in response to specific stimuli need to be developed. This study aimed to construct a hybrid nanomedicine that activated chemotherapy by inducing hypox ...
DOI:
10.1016/j.jcis.2022.09.061

6. 35 years of discussions with Prof. Maeda on the EPR effect and future directions

Author:
Yasuhiro Matsumura
Source:
Journal of controlled release 2022 v.348 pp. 966-969
ISSN:
0168-3659
Subject:
antibodies; antineoplastic agents; biocompatibility; cancer therapy; fibrin; hypoxia; malnutrition; mice; molecular weight; neoplasms; oxidative stress; permeability
Abstract:
... In May 2021, 35 years after first announcing the enhanced permeability and retention (EPR) effect, Dr. Maeda passed away. As a theoretical pillar of high molecular weight drug delivery systems (DDS) with high biocompatibility, the EPR effect has been proven worldwide in experimental mouse models. However, in clinical solid tumors, awareness of the EPR effect is insufficient, and more importantly, ...
DOI:
10.1016/j.jconrel.2022.06.035

7. 3D microgels to quantify tumor cell properties and therapy response dynamics

Author:
Nila C. Wu; Jose L. Cadavid; Xinzhu Tan; Simon Latour; Stefano Scaini; Priya Makhijani; Tracy L. McGaha; Laurie Ailles; Alison P. McGuigan
Source:
Biomaterials 2022 v.283 pp. 121417
ISSN:
0142-9612
Subject:
antineoplastic agents; automation; biocompatible materials; cell growth; drug therapy; hydrogels; microgels; models; neoplasm cells; neoplasms; organoids; regrowth
Abstract:
... Tumors contain heterogeneous and dynamic populations of cells that do not all display the fast-proliferating properties that traditional chemotherapies target. There is a need therefore, to develop novel treatment strategies that target diverse tumor cell properties. Identifying therapy combinations is challenging however. Current approaches have relied on cell lines cultured in monolayers with tr ...
DOI:
10.1016/j.biomaterials.2022.121417

8. 3D walnut-like rare-earth gadolinium molybdate encapsulated with thermo-responsive hydrogel for sensitive electrochemical detection of anticancer drug Niftolide in human urine

Author:
Ragu Sasikumar; Byungki Kim
Source:
Colloids and surfaces 2022 v.650 pp. 129593
ISSN:
0927-7757
Subject:
antineoplastic agents; detection limit; electrochemistry; encapsulation; ethylene glycol; gadolinium; humans; hydrogels; molybdates; mortality; prostatic neoplasms; surface area; synergism; urea; urine
Abstract:
... Prostate cancer is ranked as the second most common type of cancer in men and has a high mortality rate. Niftolide (NIFT), a non-steroidal antiandrogen drug, has been extensively used in the treatment of prostate cancer; however, its improper and excessive use can lead to unwanted side effects and complications to the body. In this study, we synthesized a novel rare-earth gadolinium molybdate enca ...
DOI:
10.1016/j.colsurfa.2022.129593

9. Access to n-pentenyl tetra- and pentasaccharide analogues of the antitumor drug PI-88 based on 1,2-methyl orthoester glycosyl donors

Author:
Juan Ventura; Clara Uriel; Ana M. Gómez; J. Cristobal López
Source:
Carbohydrate research 2022 v.516 pp. 108557
ISSN:
0008-6215
Subject:
antineoplastic agents; glycosides; ortho esters; regioselectivity; research
Abstract:
... Convergent synthetic routes to PI-88 tetra- and pentasaccharide-component analogues, have been developed featuring regioselective glycosylations of mannose-polyol n-pentenyl glycosides (NPG) acceptors with 1,2-methyl orthoesters (MeOE) glycosyl donors. ...
DOI:
10.1016/j.carres.2022.108557

10. Acetylshikonin exerts anti-tumor effects on non-small cell lung cancer through dual inhibition of STAT3 and EGFR

Author:
Yemeng Tang; Yanmao Wang; Xian Wang; Zhucheng Zhao; Haijian Cai; Mengyao Xie; Xintong Jiang; Luyao Zhang; Jiayun Cheng; Lehe Yang; Liangxing Wang; Chengguang Zhao; Xiaoying Huang
Source:
Phytomedicine 2022 v.101 pp. 154109
ISSN:
0944-7113
Subject:
antineoplastic activity; antineoplastic agents; apoptosis; cell movement; drug resistance; epidermal growth factor receptors; flow cytometry; fluorescent antibody technique; humans; lung neoplasms; mechanism of action; models; morbidity; phosphorylation; proteome; signal transduction; survival rate; tetrazolium; transactivators; xenotransplantation
Abstract:
... Lung cancer is one of the most common types of malignant tumor. It has one of the highest morbidity and mortality rates worldwide, and approximately 85% of cases are non-small cell lung cancer (NSCLC). Clinically, several EGFR inhibitors have been used to treat NSCLC, but resistance can develop. Studies have shown that cross talk between signal transducer and activator of transcription 3 (STAT3) a ...
DOI:
10.1016/j.phymed.2022.154109

11. Activation of ATM/Chk2 by Zanthoxylum armatum DC extract induces DNA damage and G1/S phase arrest in BRL 3A cells.

Author:
Jialuo Jiang; Yan Huang; Wenlin Wang; Chen Sun; Qiuyan Liu; Yan Chen; Tingting Hu; Xiaoju Ma; Cheng Peng; Yuntong Ma; Shukun Liu; Chaolong Rao
Source:
Journal of ethnopharmacology 2022 v.284 pp. 114832
ISSN:
0378-8741
Subject:
DNA; DNA damage; Zanthoxylum armatum; alkaloids; antineoplastic agents; cell cycle checkpoints; cell viability; cytotoxicity; disease prevention; fatty acids; flavonoids; liquid chromatography; mammals; mass spectrometry; medicinal plants; methanol; oxidative stress; phytotoxicity; traditional medicine; China; India
Abstract:
... Zanthoxylum armatum DC is a traditional medicinal plant. It is widely used in clinical treatment and disease prevention in China, India and other regions. Modern studies have reported the phytotoxicity, cytotoxicity and the animal toxicity of Zanthoxylum armatum DC, and the damage of genetic material has been observed in plants, but the detailed mechanism has not been explored. Besides, the toxici ...
DOI:
10.1016/j.jep.2021.114832

12. Alnustone inhibits the growth of hepatocellular carcinoma via ROS‐ mediated PI3K/Akt/mTOR/p70S6K axis

Author:
Linlin Wang; Li Cheng; Li Ma; Ammad Ahmad Farooqi; Gan Qiao; Yuxi Zhang; Hanlin Ye; Minghua Liu; Jianlin Huang; Xiaohui Yang; Xiukun Lin; Shousong Cao
Source:
Phytotherapy research 2022 v.36 no.1 pp. 525-542
ISSN:
0951-418X
Subject:
acetylcysteine; antineoplastic activity; antineoplastic agents; apoptosis; growth retardation; hepatoma; humans; liver; membrane potential; mitochondrial membrane; phytotherapy; research; xenotransplantation
Abstract:
... Alnustone, a diarylheptane compound, exhibits potent growth inhibition against hepatocellular carcinoma (HCC) BEL‐7402 cells. However, the underlying mechanisms associated with its anticancer activity remain unknown. In the present study, we evaluated the anticancer effect of alnustone against several human cancers focused on HCC and the possible associated mechanisms. The results showed that alnu ...
DOI:
10.1002/ptr.7337

13. Aloe gel glucomannan induced colon cancer cell death via mitochondrial damage-driven PINK1/Parkin mitophagy pathway

Author:
Ke Zhang; Duoduo Zhang; Junqiao Wang; Yuting Wang; Jiarui Hu; Yujia Zhou; Xingtao Zhou; Shaoping Nie; Mingyong Xie
Source:
Carbohydrate polymers 2022 v.295 pp. 119841
ISSN:
0144-8617
Subject:
Aloe; antineoplastic agents; cell lines; colorectal neoplasms; cytotoxicity; gels; glucomannans; homeostasis; lysosomes; mitochondria; mitophagy; neoplasm cells; reactive oxygen species; sequence analysis; transcription factors
Abstract:
... Mitophagy can selectively remove damaged mitochondria, which is critical in regulating mitochondrial homeostasis in diseases, such as cancer. Herein, we found that Aloe gel glucomannan (AGP) significantly inhibited the proliferation of colon cancer cells. RNA-seq analysis revealed that AGP upregulated autophagy, lysosome and mitochondrial fission signal pathways in colon cancer cell line CT26. Not ...
DOI:
10.1016/j.carbpol.2022.119841

14. Anethum Graveolens Essential Oil Nanoemulsions (AGEO-NE) as an Exclusive Apoptotic Inducer in Human Lung Adenocarcinoma (A549) Cells

Author:
Haleh Sadat Tavakkol Afshari; Masoud Homayouni Tabrizi; Touran Ardalan; Neda Jalili Anoushirvani; Roya Mahdizadeh
Source:
Nutrition and cancer 2022 v.74 no.4 pp. 1411-1419
ISSN:
1532-7914
Subject:
Anethum graveolens; adenocarcinoma; antineoplastic agents; antioxidant activity; antioxidants; apoptosis; biocompatibility; cell lines; cell viability; cytotoxicity; encapsulation; epithelium; essential oils; fibroblasts; flow cytometry; gene expression; humans; lung neoplasms; lungs; nanoemulsions; nutrition; ultrasonic treatment
Abstract:
... Anethum graveolens essential oil (AGEO) is used as an anticancer compound that can be made more efficacious by improving its biosolubility and biocompatibility. In the current study, we aimed to improve AGEO bioactivity using the nanoemulsion-based encapsulation technique. To formulate stable AGEO-NE, an ultrasonication method was utilized. The size, stability, and morphology of the AGEO-NE was me ...
DOI:
10.1080/01635581.2021.1952450

15. Anti-tumor and immunomodulation activity of polysaccharides from Dendrobium officinale in S180 tumor-bearing mice

Author:
Chuanbo Sun; Nuo Zhang; Guangpei Xu; Ping Jiang; Shiping Huang; Qun Zhao; Yanfei He
Source:
Journal of functional foods 2022 v.94 pp. 105105
ISSN:
1756-4646
Subject:
Dendrobium officinale; antibodies; antineoplastic agents; colorimetry; galactose; glucose; immunomodulation; immunomodulators; mannose; molecular weight; neoplasms; polysaccharides; splenocytes
Abstract:
... This study aims to explore the structural features and anti-tumor and immunomodulation activity of polysaccharides from Dendrobium officinale that were prepared using DEAE Sephadex A-50 and Sephadex G100. DOP structure was characterized using colorimetry, HPGPC, GC–MS, FT-IR, and NMR. The molecular weight of DOP was 1.89 × 10⁵ Da. And the DOP consisted of D-mannose, D-glucose, and D-galactose in a ...
DOI:
10.1016/j.jff.2022.105105

16. Antibacteria, Antiurease, and Antiproliferative Abruquinones from Abrus precatorius Roots

Author:
Emeka E. Okoro; Malik Shoaib Ahmad; Rukesh Maharjan; Majid Khan; Zaid A. Sherwani; Zaheer Ul-Haq; Samuel E. Ugheighele; Ochuko L. Erukainure; Omolaja R. Osoniyi; Funmilayo D. Onajobi; M. Iqbal Choudhary
Source:
Journal of Biologically Active Products from Nature 2022 v.12 no.3 pp. 276-290
ISSN:
2231-1874
Subject:
Abrus precatorius; active sites; antineoplastic agents; breast neoplasms; cytotoxicity; drug development; methanol; multiple drug resistance; phytochemicals; therapeutics; urease
Abstract:
... Phytochemical studies of methanol soluble fractions of Abrus precatorius Linn (Fabaceae) led to the isolation of four abruquinones (abruquinones M, A, E, and B). Structures of the compounds were elucidated using spectroscopic analyses - 1D, 2D NMR, HRESI-MS. Evaluation of the therapeutic effects of A. precatorius fractions showed significant (p < 0.05) antibacterial and antiurease activities. Furt ...
DOI:
10.1080/22311866.2022.2069154

17. Anticancer Effects of Combination of Indole-3-Carbinol and Hydroxychloroquine on Ehrlich Ascites Carcinoma via Targeting Autophagy and Apoptosis

Author:
Thoria Donia; Marian N Gerges; Tarek M Mohamed
Source:
Nutrition and cancer 2022 v.74 no.5 pp. 1802-1818
ISSN:
1532-7914
Subject:
Brassicaceae; antineoplastic activity; antineoplastic agents; apoptosis; ascites; autophagy; blood serum; body weight; carcinoma; caspase-3; females; gene expression; histopathology; mice; models; nutrition
Abstract:
... Indole-3-carbinol (I3C) is an active component of cruciferous vegetables which is considered a promising antineoplastic agent. This study aimed to assess I3C antineoplastic activity alone and with hydroxychloroquine (HCQ) on Ehrlich ascites carcinoma (EAC) model. Eighty female mice were divided into six groups wherein all groups except groups I and II received EAC cells (10⁶ cells/mouse i.p.). Gro ...
DOI:
10.1080/01635581.2021.1960388

18. Anticancer activity of Alpinia purpurata (Vieill) K. Schum. against MNU and testosterone induced prostate cancer in male Wistar albino rats

Author:
Anusooriya Palanirajan; Poornima Kannappan; Gopalakrishnan Velliyur Kanniappan
Source:
Pharmacological research 2022 v.3 pp. 100105
ISSN:
2667-1425
Subject:
Alpinia purpurata; Oriental traditional medicine; albino; anesthesia; antineoplastic activity; antineoplastic agents; antioxidants; blood serum; carcinoma; caudal vein; cervical dislocation; chloroform; ethyl acetate; herbal medicines; histopathology; ingredients; intraperitoneal injection; intravenous injection; kidneys; leaf extracts; leaves; lipids; liver; males; nucleic acids; propylene glycol; prostate gland; prostatic neoplasms; protein content; research; seminal vesicles; testosterone; toxicity
Abstract:
... Numerous Chinese herbal extracts have been proved to inhibit the development of prostate cancer. Zingiberaceae family is one type of plant used as an ingredient in traditional Chinese medicine (TCM). The genus Alpinia species of the Zingiberaceae family are well-known traditional herbal medicine for anti-inflammatory, antioxidant, antimicrobial, anti-dermatophytic, anti-nociceptive, hepatoprotecti ...
DOI:
10.1016/j.prmcm.2022.100105

19. Anticancer activity of D-LAK-120A, an antimicrobial peptide, in non-small cell lung cancer (NSCLC)

Author:
Suyash M. Patil; Nitesh K. Kunda
Source:
Biochimie 2022 v.201 pp. 7-17
ISSN:
0300-9084
Subject:
DNA replication; antimicrobial peptides; antineoplastic activity; antineoplastic agents; apoptosis; cancer therapy; cell movement; cell proliferation; cytotoxicity; drug resistance; drug therapy; interphase; lactate dehydrogenase; lung neoplasms; membrane potential; mitochondrial membrane; neoplasm cells; propidium
Abstract:
... Non-small cell lung cancer (NSCLC) is a major cause of global cancer mortalities and accounts for approximately 80–85% of reported lung cancer cases. Conventional chemotherapeutics show limited application because of poor tumor selectivity and acquired drug resistance. Antimicrobial peptides (AMPs) have gained much attention as potential anticancer therapeutics owing to their high potency and high ...
DOI:
10.1016/j.biochi.2022.06.011

20. Anticancer activity of N-heteroaryl acetic acid salts against breast cancer; in silico and in vitro investigation

Author:
Samaneh Zolghadri; Ali Ghanbariasad; Fatemeh Fallahian; Mahdie Rahban; Mahsa Kalavani; Enayatollah Bahman Jahromi; Azizeh Asadzadeh; Maliheh Hajiani
Source:
Molecular biology reports 2022 v.49 no.1 pp. 363-372
ISSN:
0301-4851
Subject:
acetic acid; antineoplastic activity; antineoplastic agents; apoptosis; breast neoplasms; cancer therapy; caspase-3; caspase-8; computer simulation; cytotoxicity; flow cytometry; gene expression; genes; histone deacetylase; inhibitory concentration 50; mechanism of action; molecular biology; neoplasm cells; quantitative polymerase chain reaction
Abstract:
... BACKGROUND: The present research was performed to assess N-heteroaryl acetic acid salts' anticancer activity against the breast cancer cell in order to introduce new inhibitory agents for histone deacetylase. METHODS AND RESULTS: A molecular docking simulation was performed to design the rational novel compounds. Afterward, the best compounds were selected for synthesis. The cytotoxic effects and ...
DOI:
10.1007/s11033-021-06881-1

21. Anticancer activity of Neptunia oleracea methanolic extracts

Author:
Archana Bhumireddy; Kavitha Nellore; Krishna Satya Alapati
Source:
Natural product research 2022 v.36 no.4 pp. 1053-1057
ISSN:
1478-6427
Subject:
Neptunia oleracea; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle; dysentery; ethnobotany; medicinal plants; neoplasm cells; neoplasms; phytochemicals; research
Abstract:
... Neptunia oleracea Lour (water mimosa) is an edible medicinal plant used in treating various diseases. According to Phytochemical and Ethnobotanical Databases, Neptunia oleracea Lour is used in curing earaches, dysentery, syphilis, and tumour. The present study was aimed at demonstrating the anticancer activity of the Neptunia oleracea Lour methanolic extract. The methanolic extract was isolated an ...
DOI:
10.1080/14786419.2020.1844693

22. Anticancer activity of chicken cathelicidin peptides against different types of cancer

Author:
Maged Mostafa Mahmoud; Modhi Alenezi; Ahmed M. Al-Hejin; Turki S. Abujamel; Fadwa Aljoud; Abdulwahab Noorwali; Ibrahim A. Awad; Mohammed Alkhaled; Haitham A. Yacoub
Source:
Molecular biology reports 2022 v.49 no.6 pp. 4321-4339
ISSN:
0301-4851
Subject:
antineoplastic activity; antineoplastic agents; ascites; breast neoplasms; caspase-3; cathelicidins; chickens; colorectal neoplasms; cyclins; humans; immunohistochemistry; mechanism of action; models; molecular biology; necrosis; neoplasm cells
Abstract:
... BACKGROUND: This study served as the pioneer in studying the anti-cancer role of chicken cathelicidin peptides. METHODS AND RESULTS: Chicken cathelicidins were used as anticancer agent against the breast cancer cell line (MCF-7) and human colon cancer cell line (HCT116). In addition, the mechanism of action of the interaction of cationic peptides with breast cancer cell line MCF-7 was also investi ...
DOI:
10.1007/s11033-022-07267-7

23. Anticancer effect of marine bivalves derived polysaccharides against human cancer cells

Author:
Deepakrajasekar Padmanaban; Angeline Samuel; Gracy Jenifer Sahayanathan; Kavitha Raja; Arulvasu Chinnasamy
Source:
Biocatalysis and agricultural biotechnology 2022 v.39 pp. 102240
ISSN:
1878-8181
Subject:
Bivalvia; DNA fragmentation; acridine orange; agricultural biotechnology; antineoplastic activity; antineoplastic agents; apoptosis; biocatalysis; breasts; clinical examination; colon; cytotoxicity; enzymatic hydrolysis; ethidium; humans; inhibitory concentration 50; liver; marine environment; polypeptides; polysaccharides; propidium; rhodamines; therapeutics
Abstract:
... In recent decades, studies on cancer prophylactics and therapeutics with development of novel anticancer drugs have garnered interest on a global scale. The diverse marine environment is a major source of biocompounds and has been acknowledged as an important platform for drug discovery. A wide variety of novel agents in the form of protein, polysaccharide, polypeptide and steroid from marine micr ...
DOI:
10.1016/j.bcab.2021.102240

24. Anticancer effects of picrasidine I on oral squamous cell carcinoma

Author:
Yuan‐Ting Yang; Ming‐Ju Hsieh; Yi‐Ching Chuang; Chia‐Chieh Lin; Yu‐Sheng Lo; Hsin‐Yu Ho; V. Bharath Kumar; Jiunn‐Liang Ko
Source:
Environmental toxicology 2022 v.37 no.3 pp. 627-636
ISSN:
1520-4081
Subject:
Picrasma quassioides; alkaloids; antineoplastic activity; antineoplastic agents; apoptosis; caspases; cell viability; cyclins; cytotoxicity; death; dose response; ecotoxicology; membrane potential; mitochondrial membrane; mouth neoplasms; phosphorylation; squamous cell carcinoma; therapeutics
Abstract:
... Picrasidine I is a dimeric alkaloid derived from a Southern Asian plant Picrasma quassioides and demonstrated to possess pharmacological activities, such as anti‐inflammatory and anti‐osteoclastogenic effects. However, its potential anticancer effect remains unclear. In the present study, anticancer activity of picrasidine I was assessed by treating oral squamous cell carcinoma cells with differen ...
DOI:
10.1002/tox.23430

25. Anticancer potential of Phoenix dactylifera L. seed extract in human cancer cells and pro-apoptotic effects mediated through caspase-3 dependent pathway in human breast cancer MDA-MB-231 cells: an in vitro and in silico investigation

Author:
Mohsin Ali Khan; Romila Singh; Sahabjada Siddiqui; Imran Ahmad; Rumana Ahmad; Shivbrat Upadhyay; Md. Abul Barkat; Ahmed Mahmoud Abdelhaleem Ali; Qamar Zia; Aditi Srivastava; Anchal Trivedi; Ishrat Husain; Anand Narain Srivastava; Durga Prasad Mishra
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 68
ISSN:
2662-7671
Subject:
Phoenix dactylifera; alternative medicine; amino acids; antineoplastic agents; apoptosis; breast neoplasms; caspase-3; cell proliferation; cell viability; chemical constituents of plants; computer simulation; drug development; enzyme activity; flow cytometry; fluorescent dyes; growth retardation; high performance liquid chromatography; humans; interphase; liver neoplasms; neoplasm cells; protein synthesis; quercetin; ribose; rutin; seed extracts; toxicity; tumor suppressor protein p53
Abstract:
... BACKGROUND: Phoenix dactylifera L. has a diverse set of pharmacological properties due to its distinct phytochemical profile. The purpose of this study was to investigate the anticancer potential of Phoenix dactylifera seed extract (PDSE) in human breast cancer MDA-MB-231 and MCF-7 cells, as well as liver cancer HepG2 cells, and to investigate the anticancer efficacy in triple-negative MDA-MB-231 ...
DOI:
10.1186/s12906-022-03533-0

26. Antioxidant and anticancer activities of Annona muricata L. and Antidesma bunius L. leaves, and molecular networking analysis using LC-MS/MS metabolomics

Author:
Aya Gabriella Peña; Michael Russelle Alvarez; Kimberly Delica; Patrick Gabriel Moreno; Rowell Abogado; Sheryl Joyce Grijaldo; Edcyl Lee Salac; Froila Marie Deniega; Manolo Basingan; Cherry Mae Ravidas; Francisco Heralde; Gladys Cherisse Completo; Isagani Padolina; Ruel Nacario
Source:
South African journal of botany 2022 pp. -
ISSN:
0254-6299
Subject:
Annona muricata; Antidesma bunius; Philippines; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; chlorophyll; ethyl acetate; growth retardation; hexane; humans; indoles; leaves; lung neoplasms; metabolomics; methanol; phytochemicals; toxicity testing
Abstract:
... Several natural products are known to have anticancer activity, which helps prevent cancer. This study explores the potential use of different extracts of Annona muricata L. and Antidesma bunius L. leaves as an anticancer drug by testing its anti-oxidative and anticancer properties. Furthermore, metabolomics of these plant extracts was performed to characterize them. This project studied the bioac ...
DOI:
10.1016/j.sajb.2022.06.019

27. Antitumor mechanism of combination of Angelica gigas and Torilis japonica in LNCaP prostate cancer cells via G1 arrest and inhibition of Wnt/β‐catenin and androgen receptor signaling

Author:
Dong Hee Kim; Eunji Im; Dae Young Lee; Hyo‐Jung Lee; Deok Yong Sim; Ji Eon Park; Chi‐Hoon Ahn; Ja Il Koo; Ji‐Na Pak; Sung‐Hoon Kim
Source:
Phytotherapy research 2022 v.36 no.7 pp. 2999-3008
ISSN:
0951-418X
Subject:
Angelica gigas; Torilis japonica; androgen receptors; androgens; antineoplastic agents; caspase-3; cyclin-dependent kinase; cyclins; dihydrotestosterone; fluorescence; interphase; phytotherapy; prostate-specific antigen; prostatic neoplasms; protein-protein interactions; research; viability; wnt proteins
Abstract:
... The goal of the current study is to assess the antitumor mechanism by the combination (7:3) of Angelica gigas and Torilis japonica (AT) that was found most effective through screening against prostate‐specific antigen (PSA) in LNCaP prostate cancer cells. Here, AT reduced the viability and the number of colonies in androgen‐dependent LNCaP cells more than in androgen independent PC3 and DU145 cell ...
DOI:
10.1002/ptr.7494

28. Aperture Modulation of Isoreticular Metal Organic Frameworks for Targeted Antitumor Drug Delivery

Author:
Mengru Cai; Wulin Liang; Kaixin Wang; Dongge Yin; Tingting Fu; Rongyue Zhu; Changhai Qu; Xiaoxv Dong; Jian Ni; Xingbin Yin
Source:
ACS applied materials & interfaces 2022 v.14 no.32 pp. 36366-36378
ISSN:
1944-8252
Subject:
animals; antineoplastic agents; drug delivery systems; feces; liver neoplasms; pH; peptides; polyethylene glycol; porosity; precision medicine; toxicity; urine
Abstract:
... The introduction of different pore diameters in metal organic frameworks (MOFs) could adjust their drug delivery performance. MOFs with customized structures have potential application value in targeted drug delivery. However, no research on this topic has been found so far. In this report, isoreticular metal organic frameworks (IRMOFs) have been taken as a typical case of tailor-made MOFs, the po ...
DOI:
10.1021/acsami.2c07450

29. Application of Multiple Strategies to Improve the Production of the Potential Cancer Drug 4-Acetylantroquinonol B (4-AAQB) by the Rare Fungus Antrodia cinnamomea

Author:
Huan Liu; Hao Xing; Yuhan Jin; Jie Liu; Yew-Min Tzeng; Li Deng; Fang Wang
Source:
Applied biochemistry and biotechnology 2022 v.194 no.6 pp. 2720-2730
ISSN:
0273-2289
Subject:
Taiwanofungus camphoratus; antineoplastic agents; biotechnology; cancer therapy; fruiting bodies; fungi; oleic acid; polysorbates; submerged fermentation; surfactants
Abstract:
... 4-Acetylantroquinonol B (4-AAQB) was identified in the rare fungus Antrodia cinnamomea and has been proven to be a potential therapeutic agent for cancer treatment. But the extraction of 4-AAQB from the fruit body led to a low yield and limited its further application in the pharmaceutical field. In this work, 4-AAQB production was enhanced in the submerged fermentation by the combination of exoge ...
DOI:
10.1007/s12010-022-03811-0

30. Arborinine suppresses ovarian cancer development through inhibition of LSD1

Author:
Nan Li; Liang Yang; Hongling Zuo
Source:
Life sciences 2022 v.291 pp. 120275
ISSN:
0024-3205
Subject:
Western blotting; antineoplastic activity; antineoplastic agents; cancer therapy; carcinogenesis; cell lines; cell movement; cell proliferation; cytotoxicity; dose response; drug therapy; epithelium; females; gene expression; mice; neoplasm cells; ovarian neoplasms; paclitaxel; toxicity testing
Abstract:
... Epithelial ovarian carcinoma is the most lethal female reproductive malignancy in the world. Paclitaxel and carboplatin are generally the first-line treatment drugs for ovarian cancer patients, but numerous patients may develop chemotherapy resistance. Thus, it is urgent to identify novel drugs for ovarian cancer treatment. Arborinine has been known as a broad-spectrum anti-tumor agent due to it p ...
DOI:
10.1016/j.lfs.2021.120275

31. Asymmetric total synthesis of (1S,2S,4S)-β-elemene

Author:
Wei Chen; Zhun Feng; Qiang Liu
Source:
RSC advances 2022 v.12 no.13 pp. 8249-8255
ISSN:
2046-2069
Subject:
antineoplastic agents; condensation reactions; moieties; sesquiterpenoids; stereoselectivity; China
Abstract:
... Elemenes are sesquiterpene natural products extracted from Chinese medicinal herbs and have been used as an important antitumor drug in China. Here, we report the first stereoselective total synthesis of (1S,2S,4S)-β-elemene using (R)-carvone as a chiral pool starting material. The isopropenyl moiety was achieved in a highly stereoselective manner through 1,4-Michael conjugate addition. The follow ...
DOI:
10.1039/d2ra01408d

32. Baicalein: A review on its anti‐cancer effects and mechanisms in lung carcinoma

Author:
Naveenkumar Chandrashekar; Anandakumar Pandi
Source:
Journal of food biochemistry 2022 v.46 no.9 pp. e14230
ISSN:
0145-8884
Subject:
Oriental traditional medicine; Scutellaria baicalensis; antineoplastic activity; antineoplastic agents; antioxidants; apoptosis; autophagy; cell proliferation; flavonoids; herbal tea; human health; ingredients; lung neoplasms; lungs; mechanism of action; metastasis; mortality
Abstract:
... Plant‐derived flavonoids are reported to function as potential anti‐cancer agents against different types of cancer. Baicalein (BE) is an important flavonoid found in the roots of Scutellaria baicalensis that is popularly used in Chinese medicine as an ingredient in herbal tea preparations to promote wellness. BE has been studied for its several biological effects including antioxidant, anti‐infla ...
DOI:
10.1111/jfbc.14230

33. Bioactive compound from Lagerstroemia speciosa: activating apoptotic machinery in pancreatic cancer cells

Author:
Shallu Goyal; Monika Sharma; Rohit Sharma
Source:
3 Biotech 2022 v.12 no.4 pp. 96
ISSN:
2190-572X
Subject:
Lagerstroemia; antineoplastic agents; apoptosis; bioactive compounds; caspase-3; cytotoxicity; diosgenin; flow cytometry; gene expression; leaf extracts; pancreatic neoplasms; reverse transcriptase polymerase chain reaction; silica gel; therapeutics
Abstract:
... The study was aimed at the identification of a potential anti-cancer compound from the leaf extract of Lagerstroemia speciosa, against pancreatic cancer cells (PANC-1). Out of different extracts tested, methanolic extract showed significant cytotoxicity at an IC₅₀ of 289.5 ± 0.03 µg/mL after 24 h (MTT assay). The safety of the extract was ascertained using normal pancreatic cells (hTERT-HPNE). Met ...
DOI:
10.1007/s13205-022-03155-w

34. Biosynthesis and cytotoxic effect of silymarin-functionalized selenium nanoparticles induced autophagy mediated cellular apoptosis via downregulation of PI3K/Akt/mTOR pathway in gastric cancer

Author:
Xiao-jie Mi; Han Sol Choi; Haribalan Perumalsamy; Rajeshkumar Shanmugam; Lakshmi Thangavelu; Sri Renukadevi Balusamy; Yeon-Ju Kim
Source:
Phytomedicine 2022 v.99 pp. 154014
ISSN:
0944-7113
Subject:
Silybum marianum; X-radiation; agonists; antineoplastic agents; apoptosis; autophagy; biosynthesis; caspases; cytotoxicity; herbal medicines; phosphatidylinositol 3-kinase; quantitative polymerase chain reaction; selenium; silymarin; spectrometers; stomach neoplasms; thermogravimetry
Abstract:
... Silymarin, a blend of flavonolignans isolated from plant Silybum marianum L., has long been used as an herbal medicine. Biogenic routes especially the plant-based synthesis of selenium nanoparticles (SeNPs) is safe, eco-friendly, nontoxic and being considered as one of the best strategies for treatment of cancer. Silymarin-mediated green synthesis of SeNPs and their possibility as an anticancer ag ...
DOI:
10.1016/j.phymed.2022.154014

35. Biosynthesis of Zinc Oxide Nanoparticles Using Catharanthus Roseus Leaves and Their Therapeutic Response in Breast Cancer (MDA-MB-231) Cells

Author:
Apoorva Bangroo; Akshay Malhotra; Uttam Sharma; Aklank Jain; Anupreet Kaur
Source:
Nutrition and cancer 2022 v.74 no.4 pp. 1489-1496
ISSN:
1532-7914
Subject:
Catharanthus roseus; Fourier transform infrared spectroscopy; X-ray diffraction; amides; anticarcinogenic agents; antineoplastic agents; biosynthesis; breast neoplasms; cytotoxicity; energy-dispersive X-ray analysis; humans; leaf extracts; nutrition; particle size; therapeutics; transmission electron microscopy; zinc oxide
Abstract:
... As the current study reports the utilization of the leaf extract of Catharanthus roseus (C.roseus) for the biological synthesis of zinc oxide nanoparticles (ZnO NPs) because of the importance of the importance of health and environment. Bioinspired synthesis were characterized using Fourier Transform Infrared Spectroscopy (FT-IR), Field Emission-Scanning Electron Microscopy (FE-SEM), Transmission ...
DOI:
10.1080/01635581.2021.1952622

36. Biosynthesized tin oxide-sodium alginate-polyethylene glycol-carvacrol nanocomposite shows anticancer activity on esophagus squamous carcinoma cells

Author:
Gongqian Jiang; Abubucker Peer Mohideen; Vidya Devanathadesikan Seshadri; Thamaraiselvan Rengarajan
Source:
Process biochemistry 2022 v.121 pp. 403-412
ISSN:
1359-5113
Subject:
Fourier transform infrared spectroscopy; Lamiaceae; antimicrobial properties; antineoplastic activity; antineoplastic agents; antioxidants; apoptosis; biosynthesis; carcinoma; carvacrol; cell cycle; cell lines; cytotoxicity; esophageal neoplasms; esophagus; monoterpenoids; nanocomposites; neoplasm cells; oxidative stress; polyethylene glycol; regulatory proteins; rhodamines; sodium; spectral analysis; tin; tin dioxide; toxicity testing
Abstract:
... Esophagus cancer is the sixth leading cause of cancer-related mortalities worldwide. In this study, we synthesized a biocompatible nanocomposite with green synthesized tin oxide using carvacrol, sodium allyl, and polyethylene glycol. Carvacrol is a phenolic monoterpenoid extracted from the essential oils of the plants belonging to the Lamiaceae family. Carvacrol possesses immense pharmacological p ...
DOI:
10.1016/j.procbio.2022.07.005

37. Biotechnology for micropropagation and camptothecin production in Ophiorrhiza sp.

Author:
Devendra Kumar Pandey; Merinashwari Konjengbam; Mimosa Ghorai; Padmanabh Dwivedi; Debleena Roy; Nishi Kant; A. Gangaprasad; Abhijit Dey
Source:
Applied microbiology and biotechnology 2022 v.106 no.11 pp. 3851-3877
ISSN:
0175-7598
Subject:
Apocynaceae; Betulaceae; Camptotheca acuminata; Icacinaceae; Meliaceae; Nyssaceae; Ophiorrhiza; Violaceae; antimalarials; antineoplastic agents; bark; biotechnology; callus formation; culture media; flavonoids; genetically modified organisms; microbiology; micropropagation; rhizogenesis; tissue culture; triterpenoids
Abstract:
... Camptothecin (CPT) is a monoterpenoid-alkaloid, an anticancer compound from plant. Ever since its discovery in 1996 from the bark of Camptotheca acuminata, various researches have been conducted for enhancing its production. CPT has also been reported in several other species belonging to the plant families Icacinaceae, Rubiaceae, Apocynaceae, Nyssaceae, Betulaceae, Violaceae, Meliaceae, and Gelse ...
DOI:
10.1007/s00253-022-11941-y

38. Borax Pentahydrate and Disodium Pentaborate Decahydrate Are Candidates as Anti-leukemic Drug Components by Inducing Apoptosis and Changing Bax/Bcl-2 Ratio in HL-60 Cell Line

Author:
Tuğba Erkmen; Belgin Sert Serdar; Halil Ateş; Mehmet Korkmaz; Semra Koçtürk
Source:
Biological trace element research 2022 v.200 no.4 pp. 1608-1616
ISSN:
0163-4984
Subject:
antineoplastic agents; apoptosis; borax; boron; boronic acids; cell lines; cell viability; drug development; flow cytometry; human nutrition; myeloid leukemia; myeloma; propidium; research; therapeutics; toxicity; toxicity testing
Abstract:
... Acute myeloid leukemia (AML) is the most common form of acute leukemia and has the lowest 5-year survival rates. Current treatment strategies do not meet the expectations also. Therefore, there is a need to improve therapeutic approaches still. Boron, which is a natural trace element in human diet, is gaining attention with its important roles in cellular processes for the development of new anti- ...
DOI:
10.1007/s12011-021-02802-2

39. The Bovine Serum Albumin Coated Copper Oxide Nanoparticle for Curcumin Delivery in Biological Environment: In-vitro Drug Release

Author:
Tahmineh Atloo; Ramin Mohammadkhani; Ali Mohammadi; Kasra Arbabi Zaboli; Saeed Kaboli; Hossein Rahimi; Hamed Nosrati; Hosein Danafar
Source:
Journal of polymers and the environment 2022 v.30 no.8 pp. 3203-3208
ISSN:
1566-2543
Subject:
antineoplastic activity; antineoplastic agents; atomic force microscopy; bovine serum albumin; breast neoplasms; cell lines; cupric oxide; curcumin; cytotoxicity; environment; nanocarriers; neoplasm cells; pH; particle size; toxicity testing; transmission electron microscopy
Abstract:
... The copper oxide nanoparticles (CuO NPs) were synthesized by a simple method and then coated with the bovine serum albumin (BSA) to form CuO@BSA NPs. Finally, curcumin (CUR) as an anticancer drug was loaded to the CuO@BSA NPs. The characterization of nanoparticles was carried out by Fourier-transport infrared (FT-IR), ultraviolet-visible (UV-vis), transmission electron microscopy (TEM), and atomic ...
DOI:
10.1007/s10924-022-02401-9

40. The Brassica Napus Extract (BNE)-Loaded PLGA Nanoparticles as an Early Necroptosis and Late Apoptosis Inducer in Human MCF-7 Breast Cancer Cells

Author:
Hanieh Shabestarian; Masoud Homayouni Tabrizi; Ali Es-haghi; Farzanehsadat Khadem
Source:
Nutrition and cancer 2022 v.74 no.7 pp. 2540-2549
ISSN:
1532-7914
Subject:
Brassica napus; antineoplastic agents; apoptosis; breast neoplasms; cytotoxicity; death; emulsions; evaporation; gene expression; genes; humans; necroptosis; nutrition; solvents; zeta potential
Abstract:
... Loading of the Brassica napus extract (BNE) on PLGA nanoparticle (BNE-PNP) and study its necroptotic activity in human MCF7-breast cancer cells. Double emulsion solvent evaporation methods were used for synthesis of BNE-PNP and DLS, SEM, and surface Zeta-potential analysis were applied for defining the physicochemical properties of BNE-PNP. The cytotoxic impact of BNE-PNP nanoparticles was analyze ...
DOI:
10.1080/01635581.2021.2008986

41. CN470 is a BET/CBP/p300 multi-bromodomain inhibitor and has an anti-tumor activity against MLL-rearranged acute lymphoblastic leukemia

Author:
Natsuki Imayoshi; Makoto Yoshioka; Kuniaki Tanaka; Shyh-Ming Yang; Koshi Akahane; Yuki Toda; Shigekuni Hosogi; Takeshi Inukai; Seiji Okada; David J. Maloney; Tatsutoshi Nakahata; Junko Takita; Itaru Kato; Eishi Ashihara
Source:
Biochemical and biophysical research communications 2022 v.590 pp. 49-54
ISSN:
0006-291X
Subject:
acetyltransferases; antineoplastic activity; antineoplastic agents; apoptosis; cell cycle checkpoints; cyclic AMP; genes; histones; interphase; ligands; luminescence; lymphocytic leukemia; mice; protein synthesis; research; xenotransplantation
Abstract:
... Acute lymphoblastic leukemia with chromosomal rearrangements involving the mixed-lineage leukemia (MLL) gene (MLL-r ALL) remains an incurable disease. Thus, development of a safe and effective therapeutic agent to treat this disease is crucial to address this unmet medical need. BRD4, a member of the bromodomain and extra-terminal domain (BET) protein family, and cyclic AMP response element bindin ...
DOI:
10.1016/j.bbrc.2021.12.078

42. Caffeic acid phenethyl ester induces radiosensitization via inhibition of DNA damage repair in androgen‐independent prostate cancer cells

Author:
Km Anjaly; Ashu Bhan Tiku
Source:
Environmental toxicology 2022 v.37 no.5 pp. 995-1006
ISSN:
1520-4081
Subject:
DNA damage; DNA repair; adjuvants; antineoplastic agents; apoptosis; cadherins; caffeic acid; cell growth; cell movement; dose response; ecotoxicology; gamma radiation; herbal medicines; phosphorylation; propolis; prostatic neoplasms; radiation resistance; radioprotective effect; vimentin
Abstract:
... In the present study, we evaluated the radiomodulatory potential of caffeic acid phenethyl ester (CAPE), an active component of traditional herbal medicine propolis. CAPE has been identified as a potent anticancer agent in multiple cancer types and is reported to have the dual role of radioprotection and radiosensitization. However, the radiomodulatory potential of CAPE in prostate cancer (PCa), w ...
DOI:
10.1002/tox.23459

43. Can Light Spectrum Composition Increase Growth and Nutritional Quality of Linum usitatissimum L. Sprouts and Microgreens?

Author:
Martina Puccinelli; Rita Maggini; Luciana G. Angelini; Marco Santin; Marco Landi; Silvia Tavarini; Antonella Castagna; Luca Incrocci
Source:
Horticulturae 2022 v.8 no.2 pp. -
ISSN:
2311-7524
Subject:
Linum usitatissimum; antineoplastic agents; antioxidant activity; antioxidants; blue light; carotenoids; chlorogenic acid; chlorophyll; dry matter content; flavonoids; flax; germination; health promotion; linseed; microgreens; nutritive value; phenol; secondary metabolites; seedling growth
Abstract:
... Flaxseed could be suitable for obtaining high-quality sprouts and microgreens thanks to high amounts of nutrients and antioxidant, antidiabetic, and anticancer compound content in its seeds. Recent studies highlighted that seedling growth, nutritional compound, and secondary metabolite content can be strongly managed by regulation of the light spectrum used during germination. The present study in ...
DOI:
10.3390/horticulturae8020098

44. Cancer Cell Inhibiting Sea Cucumber (Holothuria leucospilota) Protein as a Novel Anti-Cancer Drug

Author:
Ruizhen Ru; Yanzheng Guo; Juanxuan Mao; Zonghe Yu; Wen Huang; Xudong Cao; Huijian Hu; Minjie Meng; Lihong Yuan
Source:
Nutrients 2022 v.14 no.4 pp. -
ISSN:
2072-6643
Subject:
Holothuria leucospilota; Oriental traditional medicine; antineoplastic activity; antineoplastic agents; antioxidants; apoptosis; cell cycle; cell movement; cell viability; death; drug therapy; neoplasm cells; polysaccharides; saponins; toxicity
Abstract:
... Cancer remains the primary cause of death worldwide. To develop less toxic anti-cancer drugs to relieve the suffering and improve the survival of cancer patients is the major focus in the anti-cancer field. To this end, marine creatures are being extensively studied for their anti-cancer effects, since extracts from at least 10% of the marine organisms have been shown to possess anti-tumor activit ...
DOI:
10.3390/nu14040786

45. Cancer Conformational Landscape Shapes Tumorigenesis

Author:
Casimir Bamberger; Jolene Diedrich; Salvador Martìnez-Bartholomé; John R. Yates
Source:
Journal of proteome research 2022 v.21 no.4 pp. 1017-1028
ISSN:
1535-3907
Subject:
DNA; antineoplastic agents; biomarkers; carcinogenesis; cell lines; data collection; drug development; growth retardation; heat stress; lysine; mass spectrometry; neoplasm cells; neoplasms; proteome; research
Abstract:
... During tumorigenesis, DNA mutations in protein coding sequences can alter amino acid sequences which can change the structures of proteins. While the 3D structure of mutated proteins has been studied with atomic resolution, the precise impact of somatic mutations on the 3D proteome during malignant transformation remains unknown because methods to reveal in vivo protein structures in high throughp ...
DOI:
10.1021/acs.jproteome.1c00906

46. Capsaicin inhibits the stemness of anaplastic thyroid carcinoma cells by triggering autophagy‐lysosome mediated OCT4A degradation

Author:
Liying Wu; Shichen Xu; Xian Cheng; Li Zhang; Yunping Wang; Jing Wu; Jiandong Bao; Huixin Yu; Rongrong Lu
Source:
Phytotherapy research 2022 v.36 no.2 pp. 938-950
ISSN:
0951-418X
Subject:
antineoplastic agents; apoptosis; autophagy; calcium; capsaicin; carcinoma; chloroquine; phytotherapy; proteasome inhibitors; protein content; research; thyroid neoplasms; transient receptor potential vanilloid channels
Abstract:
... Capsaicin (CAP) is a well‐known anti‐cancer agent. Recently, we reported capsaicin‐induced apoptosis in anaplastic thyroid cancer (ATC) cells. It is well accepted that the generation of cancer stem cells (CSCs) is responsible for the dedifferentiation of ATC, the most lethal subtype of thyroid cancer with highly dedifferentiation status. Whether CAP inhibited the ATC growth through targeting CSCs ...
DOI:
10.1002/ptr.7361

47. Carboxylated chitosan-mediated improved efficacy of mesoporous silica nanoparticle-based targeted drug delivery system for breast cancer therapy

Author:
Garima Lohiya; Dhirendra S. Katti
Source:
Carbohydrate polymers 2022 v.277 pp. 118822
ISSN:
0144-8617
Subject:
antineoplastic agents; breast neoplasms; cancer therapy; carboxylation; chitosan; cytotoxicity; drug delivery systems; oligonucleotides; porous media; silica
Abstract:
... Nanoparticle-based targeting of overexpressed cell-surface receptors is a promising strategy that provides precise delivery of drugs to cancer cells. In the present study, we developed highly reproducible and monodispersed, chitosan-coated (pH-responsive), doxorubicin-loaded, aptamer-mesoporous silica nanoparticle (MSN) bioconjugates for actively targeting breast cancer cells harboring overexpress ...
DOI:
10.1016/j.carbpol.2021.118822

48. Cassaine diterpenoids from the seeds of Erythrophleum fordii Oliv. and their antiangiogenic activity

Author:
Zeping Chen; Ying Mou; Hao Zhong; Jiekun Xu; Xiaoqi Zhang; Guoqiang Li; Jun He; Weiku Zhang; Weihuan Huang; Haiyan Tian
Source:
Phytochemistry 2022 v.203 pp. 113399
ISSN:
0031-9422
Subject:
Erythrophleum fordii; acid hydrolysis; angiogenesis; antineoplastic agents; diterpenoids; drug development; formates; models; plant biochemistry; spectroscopy; structure-activity relationships
Abstract:
... Fourteen undescribed cassaine diterpenoids along with nine known ones were isolated from the seeds of Erythrophleum fordii Oliv. (Leguminosae). In addition, subsequent structural modification yielded ten derivatives. Their chemical structures were established by extensive spectroscopic methods and acid hydrolysis. All the diterpenoids were screened for their antiangiogenic activity using the human ...
DOI:
10.1016/j.phytochem.2022.113399

49. Cellular Calcium Signals in Cancer Chemoprevention and Chemotherapy by Phytochemicals

Author:
Xue Li; Shuhan Miao; Feng Li; Fen Ye; Guang Yue; Rongzhu Lu; Haijun Shen; Yang Ye
Source:
Nutrition and cancer 2022 v.74 no.8 pp. 2671-2685
ISSN:
1532-7914
Subject:
antineoplastic agents; apoptosis; calcium; cancer therapy; cell proliferation; chemoprevention; drug resistance; drug therapy; metastasis; neoplasm cells; neoplasm progression; nutrition; phytochemicals; secondary metabolites
Abstract:
... Identifying novel agents for cancer treatment is critical because of obstacles with anticancer drug resistance and lack of drug effectiveness. Intracellular calcium ion (Ca²⁺), a common second messenger, regulates various cellular pathophysiological processes including cell proliferation, differentiation and apoptosis. Recent studies have shown that the remodeling of Ca²⁺ signals is associated wit ...
DOI:
10.1080/01635581.2021.2020305

50. Cellulose nanocrystals based delivery vehicles for anticancer agent curcumin

Author:
Rajesh Kumar; Sandeep Chauhan
Source:
International journal of biological macromolecules 2022 v.221 pp. 842-864
ISSN:
0141-8130
Subject:
antineoplastic agents; bioavailability; biocompatibility; biomass; cellulose; crystal structure; curcumin; emulsifying; encapsulation; hydrophilicity; hydrophobicity; lignocellulose; lipophilicity; nanocrystals
Abstract:
... Cancer is a complex disease that starts with genetic alterations and mutations in healthy cells. The past decade has witnessed a huge demand for new biocompatibility and high-performance intelligent drug delivery systems. Curcumin (CUR) is a bioactive stimulant with numerous medical benefits. However, because of its hydrophobic nature, it has low bioavailability. The utilization of many biobased m ...
DOI:
10.1016/j.ijbiomac.2022.09.077

51. Changes in cytotoxic capacity, phenolic profile, total phenols and flavonoids of Nigella damascena L. seed extracts under different liquid fertilization

Author:
Funda Ulusu; Ali Şahin
Source:
South African journal of botany 2022 v.150 pp. 500-510
ISSN:
0254-6299
Subject:
Nigella damascena; antineoplastic agents; apigenin; breasts; cytotoxicity; epicatechin; fertilizers; ferulic acid; hexane; kidneys; liquids; methanol; naringenin; neoplasm cells; p-coumaric acid; rutin
Abstract:
... Nigella damascena L. is an annual herbaceous valuable medicinal and aromatic plant in the Ranunculaceae family. For the first time with this study, the effects of different fertilizer treatments on the total phenolic-flavonoid content and phenolic compound profile in N. damascena seeds were investigated. Also, cytotoxic activities of n-hexane and methanol extracts (0–300 μg/mL) from fertilized see ...
DOI:
10.1016/j.sajb.2022.08.010

52. Characterization of Amphidinium (Amphidiniales, Dinophyceae) species from the China Sea based on morphological, molecular, and pigment data

Author:
Zhaohe Luo; Hua Zhang; Qun Li; Lei Wang; Hala F Mohamed; Songhui Lü; Haifeng Gu
Source:
Journal of oceanology and limnology 2022 v.40 no.3 pp. 1191-1219
ISSN:
2096-5508
Subject:
Amphidinium; antheraxanthin; antineoplastic agents; coasts; corals; high performance liquid chromatography; light microscopy; limnology; littoral zone; macroalgae; oceanography; phylogeny; ribosomal RNA; sand; China; South China Sea; Yellow Sea
Abstract:
... Amphidinium species are amongst the most abundant benthic dinoflagellates in marine intertidal sandy ecosystems. Some of them are able to produce a variety of bioactive compounds that can have both harmful effects and pharmaceutical potentials. The diversity of Amphidinium in shallow waters along the Chinese coast was investigated by isolating single cells from sand, coral, and macroalgal samples ...
DOI:
10.1007/s00343-021-1049-2

53. Characterization of Histidine Functionalization and Its Timing in the Biosynthesis of Ribosomally Synthesized and Posttranslationally Modified Thioamitides

Author:
Ling Hu; Yi Qiao; Jingyu Liu; Chao Zheng; Xiaofeng Wang; Peng Sun; Yucheng Gu; Wen Liu
Source:
Journal of the American Chemical Society 2022 v.144 no.10 pp. 4431-4438
ISSN:
1520-5126
Subject:
antineoplastic agents; biosynthesis; drug development; histidine; peptides; signal peptide
Abstract:
... Thioamitides are ribosomally synthesized and posttranslationally modified peptide (RiPP) natural products that hold great potential in anticancer drug development. Members in this RiPP family feature a thioamidated peptidyl chain conjugated with a macrocyclic ring system that contains two nonproteinogenic residues, 2-aminovinyl-cysteine (AviCys) and β-hydroxy-N,N-dimethyl-l-histidine (hdmHis). Foc ...
DOI:
10.1021/jacs.1c11669

54. Characterization of lipid droplets from a Taxus media cell suspension and their potential involvement in trafficking and secretion of paclitaxel

Author:
Abdulsamie Hanano; Edgar Perez-Matas; Mouhnad Shaban; Rosa M. Cusido; Denis J. Murphy
Source:
Plant cell reports 2022 v.41 no.4 pp. 853-871
ISSN:
0721-7714
Subject:
antineoplastic agents; aqueous solutions; biosynthesis; enzyme activity; lipids; metabolites; paclitaxel; secretion
Abstract:
... KEY MESSAGE: Our paper describes the potential roles of lipid droplets of Taxus media cell suspension in the biosynthesis and secretion of paclitaxel and, therefore, highlights their involvement in improving its production. Paclitaxel (PTX) is a highly potent anticancer drug that is mainly produced using Taxus sp. cell suspension cultures. The main purpose of the current study is to characterize c ...
DOI:
10.1007/s00299-021-02823-0

55. Chemical constituents, antioxidant, and anticancer activities of bee pollen from various floral sources in Taiwan

Author:
Hoang Chinh NGUYEN; Liang-Chih LIU; WU Ming-Cheng; Tai-Pei LIN; Chiou-Ying YANG; Meng-Yuan HUANG
Source:
Notulae botanicae Horti Agrobotanici Cluj-Napoca 2022 v.50 no.2 pp. -
ISSN:
1842-4309
Subject:
anthocyanins; antineoplastic activity; antineoplastic agents; antioxidants; bee pollen; breast neoplasms; carotenoids; cell viability; chlorophyll; health promotion; inhibitory concentration 50; neoplasm cells; Taiwan
Abstract:
... Bee pollen has been traditionally used for health promotion. However, the chemical constituents and pharmaceutical effects of bee pollen strongly depend on their sources. This study determined chemical compositions and evaluated the antioxidant and anticancer activity of six bee pollen samples from Taiwan. The Cs sample contained the highest amounts of carotenoid (417.67 mg/g DW) and anthocyanin ( ...
DOI:
10.15835/nbha50212644

56. Chemical investigation and screening of anti-cancer potential of Syzygium aromaticum L. bud (clove) essential oil nanoemulsion

Author:
Atena Vafaei Malek Abadi; Ehsan Karimi; Ehsan Oskoueian; Ghasem Rahimi Kalateh Shah Mohammad; Negin Shafaei
Source:
3 Biotech 2022 v.12 no.2 pp. 49
ISSN:
2190-572X
Subject:
Syzygium aromaticum; antineoplastic activity; antineoplastic agents; apoptosis; cancer therapy; colorectal neoplasms; cytotoxicity; drug delivery systems; emulsifying; essential oils; flow cytometry; gene expression; humans; lipid peroxidation; liver; nanoemulsions; viability
Abstract:
... This study was done to improve the medicinal properties of Syzygium Aromaticum L by processing S. Aromaticum L. bud essential oil (SABE) to the Nanoemulsion drug delivery system (SABE-NE) and investigating its anti-tumor and apoptotic impacts against the human HT-29 colon cancer cells. Applying the ultra-sonication method and characterization by DLS and FESEM analysis facilitates the nanoemulsific ...
DOI:
10.1007/s13205-022-03117-2

57. Chemically engineering the drug release rate of a PEG-paclitaxel conjugate using click and steric hindrance chemistries for optimal efficacy

Author:
Anne Nguyen; Po-Han Chao; Chun Yat Ong; Elham Rouhollahi; Nojoud AL Fayez; Louis Lin; Jennifer I. Brown; Roland Böttger; Brent Page; Harvey Wong; Shyh-Dar Li
Source:
Biomaterials 2022 v.289 pp. 121735
ISSN:
0142-9612
Subject:
animals; antineoplastic agents; apoptosis; biocompatible materials; hydrophilicity; neoplasm progression; paclitaxel; pharmacokinetics; remission; solubility
Abstract:
... A small molecule drug with poor aqueous solubility can be conjugated to a hydrophilic polymer like poly(ethylene glycol) (PEG) to form an amphiphilic polymer-drug conjugate that self-assembles to form nanoparticles (NPs) with improved solubility and enhanced efficacy. This strategy has been extensively applied to improve the delivery of several small molecule drugs. However, very few reports have ...
DOI:
10.1016/j.biomaterials.2022.121735

58. Chitosan-modified nanocarriers as carriers for anticancer drug delivery: Promises and hurdles

Author:
Fahad Saad Alhodieb; Md. Abul Barkat; Harshita Abul Barkat; Hazrina Ab Hadi; Muhammad Idreesh Khan; Fauzia Ashfaq; Mohammad Akhlaquer Rahman; Mohd. Zaheen Hassan; Abdulkareem A. Alanezi
Source:
International journal of biological macromolecules 2022 v.217 pp. 457-469
ISSN:
0141-8130
Subject:
antineoplastic agents; bioadhesives; biocompatibility; biodegradability; chitosan; drug therapy; nanocarriers
Abstract:
... With the advent of drug delivery, various polymeric materials are being explored to fabricate numerous nanocarriers. Each polymer is associated with a few characteristics attributes which further facilitate its usage in drug delivery. One such polymer is chitosan (CS), which is extensively employed to deliver a variety of drugs to various targets, especially to cancer cells. The desired properties ...
DOI:
10.1016/j.ijbiomac.2022.06.201

59. Clove Flower Extract (Syzygium aromaticum) Has Anticancer Potential Effect Analyzed by Molecular Docking and Brine Shrimp Lethality Test (BSLT)

Author:
Eduardus Bimo Aksono; Aprilia Cahya Latifah; Lucia Tri Suwanti; Kautsar Ul Haq; Herinda Pertiwi
Source:
Veterinary medicine international 2022 v.2022 pp. -
ISSN:
2042-0048
Subject:
Artemia salina; Syzygium aromaticum; acetates; animals; antineoplastic agents; cancer therapy; cell proliferation; cloves; death; drug therapy; equations; eugenol; flower extracts; health services; industry; lethal concentration 50; mortality; neoplasm cells; nitric oxide synthase; probit analysis; seawater; veterinary medicine
Abstract:
... Various anticancer medications have been discovered due to advances in the health care industry, but they have undesirable side effects. On the other hand, anticancer drugs derived from natural sources have low side effects, making them excellent for cancer therapy. This study aims to evaluate the effect of clove flower extract (Syzygium aromaticum) as a potential anticancer agent by determining g ...
DOI:
10.1155/2022/5113742

60. Co-delivery of nitric oxide and camptothecin using organic-inorganic composite colloidal particles for enhanced anticancer activity

Author:
Li-Hao Chang; Teh-Min Hu
Source:
Colloids and surfaces 2022 v.632 pp. 127740
ISSN:
0927-7757
Subject:
anisotropy; antineoplastic activity; antineoplastic agents; cytotoxicity; drug therapy; nanocarriers; neoplasm cells; nitric oxide; organosilicon compounds; water solubility
Abstract:
... Camptothecin (CPT) is a highly potent anticancer agent with low water solubility and high toxicity. Nitric oxide (NO) is a gaseous free-radical molecule with potential to enhance anticancer chemotherapy. In this study, we designed and fabricated hybrid colloidal particle carriers for simultaneous delivery of CPT and NO, aiming to produce augmented anticancer activities. The drug carrier contains t ...
DOI:
10.1016/j.colsurfa.2021.127740

61. Coculture in vitro with endothelial cells induces cytarabine resistance of acute myeloid leukemia cells in a VEGF-A/VEGFR-2 signaling–independent manner

Author:
Shuichiro Okamoto; Kei Miyano; Keisuke Kitakaze; Hitomi Kato; Akira Yamauchi; Mizuho Kajikawa; Momoe Itsumi; Chikage Kawai; Futoshi Kuribayashi
Source:
Biochemical and biophysical research communications 2022 v.587 pp. 78-84
ISSN:
0006-291X
Subject:
CRISPR-Cas systems; antineoplastic agents; apoptosis; bone marrow; cell movement; coculture; endothelial cells; humans; myeloid leukemia; phosphorylation; research; vascular endothelial growth factor A; vascular endothelial growth factor receptor-2
Abstract:
... An interaction between acute myeloid leukemia (AML) cells and endothelial cells in the bone marrow seems to play a critical role in chemosensitivity on leukemia treatment. The endothelial niche reportedly enhances the paracrine action of the soluble secretory proteins responsible for chemoresistance in a vascular endothelial growth factor A (VEGF-A)/VEGF receptor 2 (VEGFR-2) signaling pathway–depe ...
DOI:
10.1016/j.bbrc.2021.11.090

62. Complexes of сarboxymethylcellulose with Cu2+-ions as a prototype of antitumor agent

Author:
M.A. Orlova; V.V. Spiridonov; A.P. Orlov; N.S. Zolotova; A.Yu. Lupatov; T.P. Trofimova; S.N. Kalmykov; A.A. Yaroslavov
Source:
Colloids and surfaces 2022 v.632 pp. 127814
ISSN:
0927-7757
Subject:
antineoplastic agents; biocompatibility; carboxymethylcellulose; cell viability; cytotoxicity; electrophoresis; medicine; particle size; polymers; prototypes; solubility; thin layer chromatography
Abstract:
... The search for new promising carries and vectors for the purposes of nuclear medicine with multifunctional effects is the most difficult problem in this branch of medicine. Among the components that are used to create carriers, one of the most perspective is the polysaccharide carboxymethylcellulose (CMC). This choice is due to CMC high solubility in aqueous and saline solutions, low toxicity, hig ...
DOI:
10.1016/j.colsurfa.2021.127814

63. Comprehensive proteomics and sialiomics of the anti-proliferative activity of safranal on triple negative MDA-MB-231 breast cancer cell lines

Author:
Mahshid Zarrineh; Shahrbanou Ashrafian; Pia Jensen; Arkadiusz Nawrocki; Alireza Madjid Ansari; Hassan Rezadoost; Alireza Ghassempour; Martin R. Larsen
Source:
Journal of proteomics 2022 v.259 pp. 104539
ISSN:
1874-3919
Subject:
DNA fragmentation; adhesion; antineoplastic agents; apoptosis; bioinformatics; breast neoplasms; cell adhesion; cell viability; cytotoxicity; glycopeptides; glycoproteins; integrins; metabolism; metastasis; mitochondria; neoplasm cells; proteome; proteomics; saffron; therapeutics; titanium dioxide; tumor necrosis factor receptors
Abstract:
... Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with no efficient treatment. Researchers have indicated the importance of quantitative approaches on proteome and different post-translation modifications studies both in diagnosis and treatment purposes. Sialic acid-containing glycopeptides (the sialiome) is one of these modifications which can be used as a tool in can ...
DOI:
10.1016/j.jprot.2022.104539

64. Comprehensive review on naringenin and naringin polyphenols as a potent anticancer agent

Author:
Abdur Rauf; Mohammad Ali Shariati; Muhammad Imran; Kashif Bashir; Shahid Ali Khan; Saikat Mitra; Talha Bin Emran; Kamala Badalova; Md. Sahab Uddin; Mohammad S. Mubarak; Abdullah S. M. Aljohani; Fahad A. Alhumaydhi; Marina Derkho; Serdar Korpayev; Gokhan Zengin
Source:
Environmental science and pollution research 2022 v.29 no.21 pp. 31025-31041
ISSN:
0944-1344
Subject:
Citrus; adhesion; antineoplastic agents; breasts; cancer therapy; caspase-3; colorectal neoplasms; drug therapy; genes; lungs; multiple drug resistance; naringenin; naringin; patients; pollution; polyphenols; prognosis; research; transcription factor NF-kappa B
Abstract:
... Though the incidence of several cancers in Western societies is regulated wisely, some cancers such as breast, lung, and colorectal cancer are currently rising in many low- and middle-income countries due to increased risk factors triggered by societal and development problems. Surgery, chemotherapy, hormone, radiation, and targeted therapies are examples of traditional cancer treatment approaches ...
DOI:
10.1007/s11356-022-18754-6

65. Conformation and anticancer activity of a novel mannogalactan from the fruiting bodies of Sanghuangporus sanghuang on HepG2 cells

Author:
Junwen Cheng; Jiling Song; Yanbin Wang; Hailong Wei; Liang He; Yu Liu; Hongmei Ding; Qingrong Huang; Chuanjiu Hu; Xubo Huang; Yihan Jiang; Youliang Wu
Source:
Food research international 2022 v.156 pp. 111336
ISSN:
0963-9969
Subject:
Western blotting; antineoplastic activity; antineoplastic agents; apoptosis; atomic force microscopy; caspase-3; flow cytometry; food research; fucose; functional foods; galactose; glucose; human cell lines; interphase; mannose; molecular weight; water solubility
Abstract:
... A novel water-soluble mannogalactan (SSPS1) with an average molecular weight of 2.04 × 10⁴ Da was obtained from the fruiting bodies of the Sanghuangporus sanghuang. It revealed that SSPS1 was composed of d-galactose, d-mannose, l-fucose, 3-O-methylgalactose and d-glucose in a ratio of 6.2:3.9:3.1:2.1:1.0. The structural elucidation of SSPS1 consisted of 1, 6-linked α-D-Galp, 1, 6-linked α-D-Manp a ...
DOI:
10.1016/j.foodres.2022.111336

66. Contact-dependent signaling triggers tumor-like proliferation of CCM3 knockout endothelial cells in co-culture with wild-type cells

Author:
Matthias Rath; Konrad Schwefel; Matteo Malinverno; Dariush Skowronek; Alexandra Leopoldi; Robin A. Pilz; Doreen Biedenweg; Sander Bekeschus; Josef M. Penninger; Elisabetta Dejana; Ute Felbor
Source:
Cellular and molecular life sciences 2022 v.79 no.6 pp. 340
ISSN:
1420-682X
Subject:
RNA; antineoplastic agents; chemokines; coculture; drug development; endothelial cells; germ cells; humans; mutants; organoids
Abstract:
... Cerebral cavernous malformations (CCM) are low-flow vascular lesions prone to cause severe hemorrhage-associated neurological complications. Pathogenic germline variants in CCM1, CCM2, or CCM3 can be identified in nearly 100% of CCM patients with a positive family history. In line with the concept that tumor-like mechanisms are involved in CCM formation and growth, we here demonstrate an abnormall ...
DOI:
10.1007/s00018-022-04355-6

67. Corilagin exhibits differential anticancer effects through the modulation of STAT3/5 and MAPKs in human gastric cancer cells

Author:
Min Hee Yang; Seung Ho Baek; Sun Tae Hwang; Jae‐Young Um; Kwang Seok Ahn
Source:
Phytotherapy research 2022 v.36 no.6 pp. 2449-2462
ISSN:
0951-418X
Subject:
antineoplastic agents; apoptosis; caspase-3; cell growth; cell viability; humans; mitogen-activated protein kinase; phosphorylation; phytotherapy; research; stomach neoplasms
Abstract:
... Corilagin (CLG) is a hydrolyzable tannin and possesses various pharmacological activities. Here, we investigated the impact of CLG as an anti‐tumor agent against human gastric tumor cells. We observed that CLG could cause negative regulation of JAKs‐Src‐STAT3/5 signaling axis in SNU‐1 cells, but did not affect these pathways in SNU‐16 cells. Interestingly, CLG promoted the induction of mitogen‐act ...
DOI:
10.1002/ptr.7419

68. Cryo-EM Structure Reveals Polymorphic Ligand-bound States of IGF1R

Author:
Xi Zhang; Tianzi Wei; Cang Wu; Junyi Jiang; Shengming Chen; Yinqing Hu; Yi Lu; Dayong Sun; Liting Zhai; Jian Zhang; Chuang Liu
Source:
Journal of molecular biology 2022 v.434 no.9 pp. 167536
ISSN:
0022-2836
Subject:
antineoplastic agents; cell growth; disulfide bonds; drug design; humans; insulin; ligands; metabolism; molecular biology; somatomedins
Abstract:
... Type 1 insulin-like growth factor receptor (IGF1R) plays an important role in regulating cellular metabolism and cell growth and has been identified as an anticancer drug target. Although previous studies have revealed some structures of IGF1R with different ligands, the continuous dynamic conformation change remains unclear. Here, we report 10 distinct structures (7.9–3.6 Å) of IGF1R bound to IGF ...
DOI:
10.1016/j.jmb.2022.167536

69. Cryptic Epoxytiglianes from the Kernels of the Blushwood Tree (Fontainea picrosperma)

Author:
Giuseppina Chianese; Hawraz Ibrahim M. Amin; Chiara Maioli; Paul Reddell; Peter Parsons; Jason Cullen; Jenny Johns; Herlina Handoko; Glen Boyle; Giovanni Appendino; Orazio Taglialatela-Scafati; Simone Gaeta
Source:
Journal of natural products 2022 v.85 no.8 pp. 1959-1966
ISSN:
1520-6025
Subject:
acylation; antineoplastic agents; chemoselectivity; diterpenoids; esterification; esters; hydrolysis; lipophilicity; nuclear magnetic resonance spectroscopy; oils; polyols; seeds; solvents; toxicity testing; trees
Abstract:
... The kernels of the Australian blushwood tree (Fontainea picrosperma) are the source of the veterinary anticancer drug tigilanol tiglate (2a, Stelfonta) and contain a concentration of phorboids significantly higher than croton oil, the only abundant source of these compounds previously known. The oily matrix of the blushwood kernels is composed of free fatty acids and not by glycerides as found in ...
DOI:
10.1021/acs.jnatprod.2c00226

70. Cyclic and dimeric fibroblast growth factor 2 variants with high biomedical potential

Author:
Mateusz A. Krzyscik; Łukasz Opaliński; Jakub Szymczyk; Jacek Otlewski
Source:
International journal of biological macromolecules 2022 v.218 pp. 243-258
ISSN:
0141-8130
Subject:
adipocytes; antineoplastic agents; cell culture; cell proliferation; drug carriers; fibroblast growth factor 2; glucose; medicine; oligomerization
Abstract:
... Fibroblast growth factor 2 (FGF2) is a pleiotropic protein engaged in the regulation of key cellular processes in a wide spectrum of cells. FGF2 is an important object of basic research as well as a molecule used in regenerative medicine, in vitro cell culture maintenance, and as an anticancer drug carrier. However, the unsatisfactory stability and pleiotropic activities of the wild-type FGF2 larg ...
DOI:
10.1016/j.ijbiomac.2022.07.105

71. Cytotoxic activity of non-specific lipid transfer protein (nsLTP1) from Ajwain (Trachyspermum ammi) seeds

Author:
Saud O. Alshammari; Taibah Aldakhil; Qamar A. Alshammari; David Salehi; Aftab Ahmed
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 135
ISSN:
2662-7671
Subject:
Trachyspermum ammi; alternative medicine; antineoplastic activity; antineoplastic agents; apoptosis; blood serum; breast neoplasms; breasts; caspase-3; cytotoxicity; half life; heat treatment; humans; lipid transfer proteins; pancreatic neoplasms; pro-apoptotic proteins; spices; temperature; thermal stability; traditional medicine
Abstract:
... BACKGROUND: Trachyspermum ammi, commonly known as Ajwain, is a member of the Apiaceae family. It is a therapeutic herbal spice with diverse pharmacological properties, used in traditional medicine for various ailments. However, all previous studies were conducted using small molecule extracts, leaving the protein’s bioactivity undiscovered. AIM: The current study aimed to demonstrate the cytotoxic ...
DOI:
10.1186/s12906-022-03616-y

72. Cytotoxic constituents of Glycosmis ovoidea collected in Vietnam

Author:
Peter J. Blanco Carcache; Gerardo D. Anaya Eugenio; Tran Ngoc Ninh; Curtis E. Moore; José Rivera-Chávez; Yulin Ren; Djaja D. Soejarto; A. Douglas Kinghorn
Source:
Fitoterapia 2022 v.162 pp. 105265
ISSN:
0367-326X
Subject:
Danio rerio; Glycosmis; Western blotting; antineoplastic agents; breast neoplasms; cell lines; computer simulation; coumarins; cytotoxicity; drug therapy; flavones; fractionation; models; national parks; neoplasm cells; Vietnam
Abstract:
... Compounds derived from natural sources have been major contributors to the area of cancer chemotherapy for decades. As part of an ongoing effort to discover anticancer drug leads from tropical plants, a large-scale collection of Glycosmis ovoidea Pierre (Rutaceae), was made at Nui Chua National Park, Vietnam. Activity-guided fractionation of the chloroform-soluble fractions led to the isolation of ...
DOI:
10.1016/j.fitote.2022.105265

73. DNA-cloaked nanoparticles for tumor microenvironment-responsive activation

Author:
Dongyoon Kim; Junho Byun; Se Ik Kim; Hyun Hoon Chung; Yong-Wan Kim; Gayong Shim; Yu-Kyoung Oh
Source:
Journal of controlled release 2022 v.350 pp. 448-459
ISSN:
0168-3659
Subject:
DNA; DNA fragmentation; antineoplastic agents; fibroblasts; hydrophobicity; intravenous injection; mass spectrometry; metabolites; nanoparticles; neoplasms; oxidative stress; polymerization; reactive oxygen species; transcription (genetics); zeta potential
Abstract:
... Although progress has been made in developing tumor microenvironment-responsive delivery systems, the list of cargo-releasing stimuli remains limited. In this study, we report DNA nanothread-cloaked nanoparticles for reactive oxygen species (ROS)-rich tumor microenvironment-responsive delivery systems. ROS is well known to strongly induce DNA fragmentation via oxidative stress. As a model anticanc ...
DOI:
10.1016/j.jconrel.2022.08.044

74. Dearomatization/Deiodination of o-Iodophenolic Compounds with α,β-Unsaturated Imines for Accessing Benzofuran Derivatives

Author:
Bigui Zhou; Zhiwei Yuan; Jingxun Yu; Xinjun Luan
Source:
Organic letters 2022 v.24 no.3 pp. 837-841
ISSN:
1523-7052
Subject:
antineoplastic agents; imines; tautomerization
Abstract:
... A dearomatization/deiodination/rearomatization strategy for the [3 + 2] cyclization of o-iodophenolic substrates with α,β-unsaturated imines to construct various dihydrobenzofuran-related skeletons has been established. Tolerance to different functional groups has been tested. Mechanistic studies revealed that this domino reaction was possibly realized by the deiodination and tautomerization of th ...
DOI:
10.1021/acs.orglett.1c04065

75. Design of surface tailored carboxymethyl dextran-protein based nanoconjugates for paclitaxel: Spectroscopical characterizations and cytotoxicity assay

Author:
Monika L. Girase; Vrashabh V. Sugandhi; Pradum P. Ige; Prashant D. Jain; Sopan N. Nangare
Source:
International journal of biological macromolecules 2022 pp. -
ISSN:
0141-8130
Subject:
Maillard reaction; antineoplastic agents; biopharmaceuticals; bovine serum albumin; cell viability; crosslinking; cytotoxicity; esterification; folic acid; gelation; humans; hydrophobic bonding; lung neoplasms; paclitaxel; polymers; solubility; toxicity testing
Abstract:
... Paclitaxel (PTX) is an essential anticancer drug from the biopharmaceutical classification system (BCS) class IV. Unfortunately, PTX has some drawbacks including low solubility, cell toxicity, adverse cell reaction, etc. Therefore, folic acid (FA) tailored carboxymethyl-dextran (CMD), and bovine serum albumin (BSA) mediated nanoconjugates of paclitaxel (PTX) (FA-CMD-BSA-PTX) were designed. At firs ...
DOI:
10.1016/j.ijbiomac.2022.09.271

76. Design, molecular docking, and molecular dynamics of thiourea-iron (III) metal complexes as NUDT5 inhibitors for breast cancer treatment

Author:
Ruswanto Ruswanto; Tita Nofianti; Richa Mardianingrum; Dini Kesuma; Siswandono
Source:
Heliyon 2022 v.8 no.9 pp. e10694
ISSN:
2405-8440
Subject:
antineoplastic agents; breast neoplasms; breasts; cancer therapy; hydrolases; iron; ligands; molecular dynamics; thiourea
Abstract:
... In research, anticancer agents, such as thiourea derivative compounds, and metal complexes, such as those complexed with iron (III) metal, are often studied. The metal complexes are presumably more active than thiourea derivatives as free ligands; some negative effects may be reduced. The computational studies used in this study involved molecular docking with AutoDock and molecular dynamics (MD) ...
DOI:
10.1016/j.heliyon.2022.e10694

77. Design, synthesis and bioactivity of novel naphthalimide-benzotriazole conjugates against A549 cells via targeting BCL2 G-quadruplex and inducing autophagy

Author:
Xiao Wang; Mi Zhang; Xu-Qiong Xiong; Hao Yang; Panpan Wang; Koutian Zhang; Annoor Awadasseid; Suresh Narva; Yan-Ling Wu; Wen Zhang
Source:
Life sciences 2022 v.302 pp. 120651
ISSN:
0024-3205
Subject:
DNA damage; antineoplastic activity; antineoplastic agents; apoptosis; autophagy; death; flow cytometry; fluorescent antibody technique; genes; genetic instability; ligands; lung neoplasms; neoplasm cells
Abstract:
... In this study, a series of novel naphthalimide-benzotriazole conjugates (1a–3c) based on 1, 8-naphthalimide as a core skeleton, aiming at G-quadruplexes, were designed and synthesized, and their anti-cancer activity and mechanism were studied. Using the CCK-8 assay, FRET melting, EMSA, CD, and molecular docking, intracellular assays, western blotting, immunofluorescence, and flow cytometry. By the ...
DOI:
10.1016/j.lfs.2022.120651

78. Designing synergistic crystallization inhibitors: Bile salt derivatives of cellulose with enhanced hydrophilicity

Author:
Diana C. Novo; Chengzhe Gao; Qingqing Qi; Laura I. Mosquera-Giraldo; Glenn A. Spiering; Robert B. Moore; Lynne S. Taylor; Kevin J. Edgar
Source:
Carbohydrate polymers 2022 v.292 pp. 119680
ISSN:
0144-8617
Subject:
antineoplastic agents; bile; bile salts; cellulose; crystallization; deoxycholic acid; hydrophilicity; hydrophobicity; lithocholic acid; olefin; prostatic neoplasms
Abstract:
... Crystallization inhibitors in amorphous solid dispersions (ASD) enable metastable supersaturated drug solutions that persist for a physiologically relevant time. Olefin cross-metathesis (CM) has successfully provided multifunctional cellulose-based derivatives as candidate ASD matrix polymers. In proof of concept studies, we prepared hydrophobic bile salt/cellulose adducts by CM with naturally occ ...
DOI:
10.1016/j.carbpol.2022.119680

79. Development and evaluation of a hydrogenated rosin (β-acryloxyl ethyl) ester–bonded silica stationary phase for high-performance liquid chromatography separation of paclitaxel from yew bark

Author:
Hao Li; Wenbo Xie; Lei Zeng; Wen Li; Boan Shi; Fuhou Lei
Source:
Journal of chromatography 2022 v.1665 pp. 462815
ISSN:
0021-9673
Subject:
Fourier transform infrared spectroscopy; adsorption; antineoplastic agents; bark; biomass; enthalpy; equations; heat production; high performance liquid chromatography; hydrophobicity; ligands; nitrogen; paclitaxel; rosin; silica gel; stoichiometry; thermogravimetry
Abstract:
... Paclitaxel (PTX) is a complex diterpenoid anticancer drug whose separation from yew biomass poses a significant challenge. In this study, a new stationary phase comprising hydrogenated rosin (β-acryloxyl ethyl) ester (HRE)–bonded silica (HRE@SiO₂) is developed to separate and purify PTX from crude yew-bark extract using high-performance liquid chromatography. In HRE@SiO₂, HRE molecules, which are ...
DOI:
10.1016/j.chroma.2022.462815

80. Development and evaluation of a multicomponent bioink consisting of alginate, gelatin, diethylaminoethyl cellulose and collagen peptide for 3D bioprinting of tissue construct for drug screening application

Author:
Rency Geevarghese; Lakshmi T. Somasekharan; Anugya Bhatt; Naresh Kasoju; Renjith P. Nair
Source:
International journal of biological macromolecules 2022 v.207 pp. 278-288
ISSN:
0141-8130
Subject:
alginates; antineoplastic agents; biocompatibility; bioprinting; cell lines; cell structures; cellulose; collagen; gelatin; lung neoplasms; models; neoplasm cells; peptides; three-dimensional printing
Abstract:
... Three dimensional (3D) bioprinting technology has been making a progressive advancement in the field of tissue engineering to produce tissue constructs that mimic the shape, framework, and microenvironment of an organ. The technology has not only paved the way to organ development but has been widely studied for its application in drug and cosmetic testing using 3D bioprinted constructs. However, ...
DOI:
10.1016/j.ijbiomac.2022.02.191

81. Development of a human phage display-derived anti-PD-1 scFv antibody: an attractive tool for immune checkpoint therapy

Author:
Sepideh Safaei Ghaderi; Farhad Riazi-Rad; Elmira Safaie Qamsari; Salman Bagheri; Fatemeh Rahimi-Jamnani; Zahra Sharifzadeh
Source:
BMC biotechnology 2022 v.22 no.1 pp. 22
ISSN:
1472-6750
Subject:
DNA libraries; antibodies; antigens; antineoplastic agents; bacteriophages; biotechnology; cancer therapy; coculture; humans; immune evasion; interleukin-2; neoplasms
Abstract:
... BACKGROUND: The PD-1 checkpoint pathway plays a major role in tumor immune evasion and the development of the tumor microenvironment. Clinical studies show that therapeutic antibodies blocking the PD-1 pathway can restore anti-tumor or anti-virus immune responses by the reinvigoration of exhausted T cells. Because of the promising results of anti-PD-1 monoclonal antibodies in cancer treatment, aut ...
DOI:
10.1186/s12896-022-00752-8

82. Development of camptothecin nano-prodrugs based on trimethyl lock groups toward selective drug release in cancer cells

Author:
Aki Shibata; Yoshitaka Koseki; Keita Tanita; Ryuju Suzuki; Anh Thi Ngoc Dao; Hitoshi Kasai
Source:
Tetrahedron letters 2022 v.103 pp. 153989
ISSN:
0040-4039
Subject:
antineoplastic agents; hydrolysis; neoplasms
Abstract:
... Selective drug release at the tumor site contributes to the reduction of side effects caused by anticancer treatments. To achieve a selective drug release system in cancer cells, we designed a new prodrug in which the anticancer drug camptothecin (CPT) is linked to a trimethyl lock (TML) group by an ester bond. Evaluation of in vitro cytostatic activity and drug release kinetics of the CPT-TML nan ...
DOI:
10.1016/j.tetlet.2022.153989

83. Development of poly(p-coumaric acid) as a self-anticancer nanocarrier for efficient and biosafe cancer therapy

Author:
Liying Wang; Xinru You; Chunlei Dai; Yifen Fang; Jun Wu
Source:
Biomaterials science 2022 v.10 no.9 pp. 2263-2274
ISSN:
2047-4849
Subject:
antineoplastic activity; antineoplastic agents; biocompatible materials; biosafety; cancer therapy; nanocarriers; neoplasms; p-coumaric acid; particle size
Abstract:
... Using biocompatible polymers with potential therapeutic activity is an appealing strategy for the development of new functional drug carriers. In this study, we report the synthesis of therapeutic poly(p-coumaric acid) (PCA) from p-coumaric acid, a common plant phenolic acid with multiple bioactivities. The prepared PCA was formulated into nanoparticles (NPs) using the nanoprecipitation method and ...
DOI:
10.1039/d2bm00027j

84. Differential growth inhibition, cell cycle arrest and apoptosis of MCF-7 and MDA-MB-231 cells to holocarboxylase synthetase suppression

Author:
Siraprapa Siritutsoontorn; Witchuda Sukjoi; Steven W. Polyak; Chareeporn Akekawatchai; Sarawut Jitrapakdee
Source:
Biochemical and biophysical research communications 2022 v.593 pp. 108-115
ISSN:
0006-291X
Subject:
acetyl-CoA carboxylase; antineoplastic agents; apoptosis; biotin; biotinylation; breast neoplasms; cell cycle checkpoints; cell growth; culture media; growth retardation; human cell lines; neoplasm cells; pyruvate carboxylase; research
Abstract:
... Holocarboxylase synthetase (HLCS) catalyzes the covalent attachment of biotin onto the biotin-dependent carboxylases. Recent studies have shown that HLCS is over-expressed in breast cancer patients. Here we investigated the functional roles of free biotin and HLCS in supporting growth and migration of breast cancer cell lines. Depletion of biotin from culture medium markedly reduced biotinylation ...
DOI:
10.1016/j.bbrc.2022.01.049

85. Distribution, cytotoxicity, and antioxidant activity of fungal endophytes isolated from Tsuga chinensis (Franch.) Pritz. in Ha Giang province, Vietnam

Author:
Thi Hanh Nguyen Vu; Ngoc Son Pham; Phuong Chi Le; Quynh Anh Pham; Ngoc Tung Quach; Van The Nguyen; Thi Thao Do; Hoang Ha Chu; Quyet Tien Phi
Source:
Annals of microbiology 2022 v.72 no.1 pp. 36
ISSN:
1590-4261
Subject:
Aspergillus; Penicillium; Tsuga chinensis; antineoplastic agents; antioxidant activity; biosynthesis; cytotoxicity; endophytes; ethyl acetate; flavonoids; fungi; hydroxyl radicals; medicinal plants; medicine; minimum inhibitory concentration; paclitaxel; polymerase chain reaction; polyphenols; secondary metabolites; sequence analysis; superoxide anion; Vietnam
Abstract:
... PURPOSE: An endangered Tsuga chinensis (Franch.) Pritz. is widely used as a natural medicinal herb in many countries, but little has been reported on its culturable endophytic fungi capable of producing secondary metabolites applied in modern medicine and pharmacy. The present study aimed to evaluate the distribution of fungal endophytes and their cytotoxic and antioxidant properties. METHODS: Thi ...
DOI:
10.1186/s13213-022-01693-5

86. Disulfiram-loaded metal organic framework for precision cancer treatment via ultrasensitive tumor microenvironment-responsive copper chelation and radical generation

Author:
He Zhang; Qianyi Zhang; Ziyi Guo; Kang Liang; Cyrille Boyer; Jian Liu; Zhonghui Zheng; Rose Amal; Sung Lai Jimmy Yun; Zi Gu
Source:
Journal of colloid and interface science 2022 v.615 pp. 517-526
ISSN:
0021-9797
Subject:
antineoplastic activity; antineoplastic agents; biodegradation; cancer therapy; cell culture; chelation; chemical bonding; coordination polymers; cytotoxicity; disulfiram; hydroxyl radicals; neoplasm cells; neoplasms; zeolites
Abstract:
... Off-target toxicity remains a major limitation of current cancer therapy, necessitating an alternative precision approach to treat cancers. Herein, a tumor microenvironment (TME)-triggered anticancer strategy was developed by constructing an anti-alcoholism drug disulfiram (DSF)-loaded, Cu-doped zeolite imidazolate frameworks-8 (DSF-Cu/ZIF-8) nanoparticle followed by PEGylation (PEG-DSF-Cu/ZIF-8) ...
DOI:
10.1016/j.jcis.2022.01.187

87. Diversity and biological activity of fungal endophytes of Zingiber officinale Rosc. with emphasis on Aspergillus terreus as a biocontrol agent of its leaf spot

Author:
Suruchi Gupta; Malvi Choudhary; Baljinder Singh; Ravail Singh; Manoj K. Dhar; Sanjana Kaul
Source:
Biocatalysis and agricultural biotechnology 2022 v.39 pp. 102234
ISSN:
1878-8181
Subject:
Aspergillus terreus; Glomerella cingulata; Zingiber officinale; agricultural biotechnology; agrochemicals; antineoplastic agents; beneficial microorganisms; bioassays; biocatalysis; biological control; biological control agents; chromatography; cytotoxicity; disease control; endophytes; financial economics; fractionation; fungi; ginger; leaf spot; metabolites; niches; pharmaceutical industry; plant pathogens; sequence analysis; spectral analysis
Abstract:
... Leaf spot of ginger caused by Colletotrichum gloeosporioides is considered as a phytopathological constraint in the cultivation of ginger that has led to the economic loss of this valuable spice. Fungal endophytes serve as potent biocontrol agents for disease management because of their ability to colonize the same ecological niche similar to that of phytopathogen. The present study embarks on the ...
DOI:
10.1016/j.bcab.2021.102234

88. Edelfosine reactivates latent HIV-1 reservoirs in myeloid cells through activation of NF-κB and AP1 pathway

Author:
Madhu Rai; Kartik Rawat; Muhammad Khalid Muhammadi; Ritu Gaur
Source:
Virology 2022 v.574 pp. 57-64
ISSN:
0042-6822
Subject:
antineoplastic agents; virology; viruses
Abstract:
... The persistence of latent HIV-1 reservoirs in cells presents a formidable challenge towards a complete HIV cure. Edelfosine is an FDA-approved investigational, anti-neoplastic drug. In this study, we aimed to investigate its role as a HIV-1 Latency Reversal Agent (LRA) using latency model cell lines. Our findings demonstrated that edelfosine reactivated latent HIV-1 viruses in myeloid cells in a d ...
DOI:
10.1016/j.virol.2022.07.008

89. Effects of chemically EGFR targeting on non-targeted physical cell behaviors in 2D and 3D microfluidic cultures of invasive and non-invasive breast cancer cell lines

Author:
Shohreh Azadi; Ehsan Mohammadi; Mohammad Tafazzoli-Shadpour; Mohammad Tabatabaei
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 1-7
ISSN:
0006-291X
Subject:
actin; antineoplastic agents; biomarkers; breast neoplasms; carcinogenesis; cell viability; chemical treatment; collagen; cytoskeleton; drug therapy; myosin; neoplasm cells; research; vimentin
Abstract:
... Cancer development comprehends changes in cell structural and physical states. Cancer cells are softer than normal cells, produce higher contractile forces, and migrate more easily. While chemotherapy, targets proteins involved in biological behaviors, it may affect cell physicomechanical state due to the interconnections among signaling pathways. Here we treated non-invasive and invasive breast c ...
DOI:
10.1016/j.bbrc.2022.07.013

90. Efficient reclamation phosphate by alginate-g-BMOF using poly(N-isopropyl acrylamide-co-acrylamide) as coating for temperature-responsive slow-release P-fertilizer

Author:
Zhengxian Wang; Jiankang Lu; Chengyi Wu; Youmeng Dan; Guoxiang Li; Deyong Wu; Sheng Hu
Source:
International journal of biological macromolecules 2022 v.201 pp. 437-447
ISSN:
0141-8130
Subject:
Chinese cabbage; acrylamides; adsorbents; adsorption; antineoplastic agents; composite polymers; drug carriers; emulsions; germination; kinetics; phosphates; plant height; slow-release fertilizers; soil; sorption isotherms
Abstract:
... Poly(N-isopropyl acrylamide) and its derived copolymer, as a temperature-responsive material, are widely used in the field of anticancer drug carrier. And it also plays an important role as carrier in slow-release fertilizer in recent years. In this paper, a smart poly(N-isopropyl acrylamide-co-acrylamide)-coated Alg-BMOF (PABMOF) was fabricated in ionic liquids microemulsion ([Bmim]PF₆/TX-100/wat ...
DOI:
10.1016/j.ijbiomac.2022.01.061

91. Emerging technologies and potential applications of algae in dentistry – A critical review

Author:
Arthi Balasubramaniam; Meignana Arumugham; Senthil Nathan; MP Santhosh Kumar; K Murugesan; Selvakumar Dharmaraj; Lakshmi Thangavelu; Pradeep Kumar Yadalam; Ramya Ramadoss; Ashokkumar Veeramuthu
Source:
Journal of biotechnology 2022 pp. -
ISSN:
0168-1656
Subject:
Chlorella; Spirulina; antibiotics; antineoplastic agents; antioxidants; biobased products; biomass; biotechnology; cytokines; dentistry; drug delivery systems; macroalgae; microalgae; oral hygiene; periodontitis; secondary metabolites; synergism; toothpaste
Abstract:
... Algae are effective predecessors of nutrient foods and preventive drugs, gaining global attraction in recent years. It exhibits potent antiviral, antibacterial, antifungal, anti-inflammatory, antioxidant, anti-glycemic, and cholesterol-lowering properties due to their richness in highly valuable secondary metabolites. Nevertheless, algae produce valuable bioproducts, its application in dentistry i ...
DOI:
10.1016/j.jbiotec.2022.09.021

92. Emerging uses of PLA–PEG copolymer in cancer drug delivery

Author:
Rohit Mundel; Tanya Thakur; Mary Chatterjee
Source:
3 Biotech 2022 v.12 no.2 pp. 41
ISSN:
2190-572X
Subject:
antineoplastic agents; biodegradability; composite polymers; drug carriers; drug therapy; micelles; neoplasms; polyethylene glycol; polylactic acid; surfactants; toxicity
Abstract:
... Traditional therapies need high systematic dosages that not only destroys cancerous cells but also healthy cells. To overcome this problem recent advancement in nanotechnology specifically in nanomaterials has been extensively done for various biological applications, such as targeted drug delivery. Nanotechnology, as a frontier science, has the potential to break down all the obstacles to be more ...
DOI:
10.1007/s13205-021-03105-y

93. Enantioselective Palladium-Catalyzed Arylborylation/Cyclization of Alkenes to Access Boryl-Functionalized Heterocyclic Compounds Containing Quaternary Stereogenic Centers

Author:
Xingfeng Bai; Wenrui Zheng; Shaozhong Ge; Yixin Lu
Source:
Organic letters 2022 v.24 no.16 pp. 3080-3085
ISSN:
1523-7052
Subject:
alkenes; antineoplastic agents; carbon; enantioselectivity; heterocyclic compounds
Abstract:
... Asymmetric palladium-catalyzed arylboration/cyclization of both nonactivated and activated alkenes with B₂pin₂ was developed. A wide range of N-allyl-o-iodobenzamides and o-iodoacryanilides reacted with B₂pin₂ to afford borylated 3,4-dihydroisoquinolinones and oxindoles, respectively, in high yields with high enantioselectivities. The synthetic utility of this enantioselective protocol was highlig ...
DOI:
10.1021/acs.orglett.2c01082

94. Endocytosis-mediated triple-activable prodrug nanotherapeutics potentiating therapeutic efficacy and security towards solid tumors

Author:
Shuwen Fu; Shilin Ma; Xinxuan Peng; Han Qiao; Wenli Zang; Jing Ye; Wenfeng Zang; Mohan Li; Kexin Shi; Xuanjiayi Ye; Wei Sun; Yinglei Zhai
Source:
Colloids and surfaces 2022 v.218 pp. 112723
ISSN:
0927-7765
Subject:
acidity; antineoplastic agents; apoptosis; blood circulation; breast neoplasms; colorectal neoplasms; disulfides; endocytosis; neoplasm cells; paclitaxel; polyethylene; surfactants; therapeutics
Abstract:
... Self-assembling prodrug nanotherapeutics have emerged as a promising nanoplatform for anticancer drug delivery. The specific and efficient activation of prodrug nanotherapeutics inside tumor cells is vital for the antitumor efficacy and security. Herein, a triple-activable prodrug polymer (TAP) is synthesized by conjugating polyethylene glycol-poly-(caprolactone)-paclitaxel (PTX) polymer with two ...
DOI:
10.1016/j.colsurfb.2022.112723

95. Enhanced anticancer effect of quercetin microparticles formulation obtained by spray drying

Author:
Roberto Caruana; Francesco Montalbano; Maria Grazia Zizzo; Roberto Puleio; Gaetano Caldara; Luca Cicero; Giovanni Cassata; Mariano Licciardi
Source:
International journal of food science & technology 2022 v.57 no.5 pp. 2739-2746
ISSN:
0950-5423
Subject:
adjuvants; antineoplastic activity; antineoplastic agents; bioavailability; colorectal neoplasms; food science; humans; milk; models; oral administration; quercetin; solubility; spray drying; synthetic products; whey; xenotransplantation
Abstract:
... This study unravels a formulation made of food‐based microparticles (MPs) able to control the release of quercetin, a natural anticancer compound, which activity is only limited by its poor aqueous solubility and consequent low bioavailability. To solve this issue, a spray‐dried micro delivery system was developed using a bench mini spray dryer B290 Buchi. The resulting MPs were only manufactured ...
DOI:
10.1111/ijfs.15539

96. Enzymatic drug release cascade from polymeric prodrug nanoassemblies enables targeted chemotherapy

Author:
Jiajia Xiang; Jing Liu; Xin Liu; Quan Zhou; Zhihao Zhao; Ying Piao; Shiqun Shao; Zhuxian Zhou; Jianbin Tang; Youqing Shen
Source:
Journal of controlled release 2022 v.348 pp. 444-455
ISSN:
0168-3659
Subject:
antineoplastic agents; catalytic activity; cytotoxicity; drug therapy; phenylboronic acids; polymers; quinones; reactive oxygen species; transportation
Abstract:
... Cancer drug delivery systems often suffer from premature drug leakage during transportation and/or inefficient drug release within cancer cells. We present here a polymeric prodrug nanoassembly that addresses these problems simultaneously. This nanoassembly comprises a polymeric prodrug with novel trivalent phenylboronate moieties for drug conjugation via ether linkages, as well as β-lapachone (La ...
DOI:
10.1016/j.jconrel.2022.06.007

97. Ethnopharmacological evaluation of antioxidant, anti-angiogenic, and anti-inflammatory activity of some traditional medicinal plants used for treatment of cancer in Togo/Africa

Author:
P. Kola; K. Metowogo; S.N. Manjula; G. Katawa; H. Elkhenany; K.M. Mruthunjaya; K. Eklu-Gadegbeku; K.A. Aklikokou
Source:
Journal of ethnopharmacology 2022 v.283 pp. 114673
ISSN:
0378-8741
Subject:
Bauhinia thonningii; Cochlospermum; Paullinia pinnata; Securidaca longipedunculata; angiogenesis; anti-inflammatory activity; antineoplastic agents; antioxidant activity; antioxidants; bovine serum albumin; cytotoxicity; denaturation; egg albumen; flavonoids; inhibitory concentration 50; medicinal plants; neoplasm cells; polyphenols; traditional medicine; Africa
Abstract:
... Cancer is a multistep disease and its management is exceedingly expensive. Nowadays medicinal plants are gaining more attention in drug discovery and approximately 70% of anticancer drugs were developed from natural products or plants. A strong candidate from medicinal plant with anticancer potential should have four major properties: antioxidant, anti-inflammatory, anti-angiogenic, and cytotoxic ...
DOI:
10.1016/j.jep.2021.114673

98. Eucalyptus kino: a treasure trove of polyphenols eradicating tumors in-vivo by elevating caspase-3 level, inhibiting TGF-β and NF-κb gene expression

Author:
Omar M. Sabry; Miral O. Sabry; Sawsan M. El-Sonbaty; Khaled M. Meselhy
Source:
Natural product research 2022 v.36 no.10 pp. 2654-2659
ISSN:
1478-6427
Subject:
Eucalyptus; antineoplastic activity; antineoplastic agents; antioxidants; apoptosis; ascites; biomarkers; carcinoma; caspase-3; females; gene expression; metabolites; methanol; neoplasm progression; polyphenols; research
Abstract:
... 30 secondary polyphenolic metabolites were characterised in Eucalyptus kino methanol extract using HPLC-MS/MS. The antitumor activity of the extract in combination with low level ionising radiation in female mice with solid tumors from inoculated Ehrlich ascites carcinoma cells was investigated. Tumor cell-inoculated mice received daily extract doses (100 mg/kg, 200 mg/kgBW) with or without a sing ...
DOI:
10.1080/14786419.2021.1916018

99. Euphorbia granulata Forssk: Evaluation of antioxidant activity, cytotoxicity, and apoptosis induction in breast cancer cells

Author:
Behnam Mahdavi; Habibeh Zare; Maryam Qorbani; Hadi Atabati; Mohammad Reza Vaezi Kakhki; Amir Raoofi; Vahid Ebrahimi
Source:
South African journal of botany 2022 v.150 pp. 576-582
ISSN:
0254-6299
Subject:
Euphorbia; antineoplastic agents; antioxidant activity; apoptosis; breast neoplasms; caspase-3; cell viability; cytotoxicity; free radicals; human cell lines; rutin
Abstract:
... Euphorbia is one of the six largest genera of flowering plants. The Euphorbia species are widely distributed throughout the world. So, the aim of this study was to investigate the phenolic compounds profile, antioxidant activity, cytotoxicity, and apoptosis induction of Euphorbia. granulata extract (EGE) on breast cancer cells. In this experiment, we used HPLC analysis to attain the phenolic and f ...
DOI:
10.1016/j.sajb.2022.08.015

100. Exploring the structural and functional requirements of Phyto-compounds and their synthetic scaffolds as anticancer agents: Medicinal chemistry perspective

Author:
Dipanjan Karati; Dileep Kumar
Source:
Pharmacological research 2022 v.4 pp. 100123
ISSN:
2667-1425
Subject:
antineoplastic agents; chemistry; drug design; health services; humans; industry; mortality; phytochemicals; research; secondary metabolites; traditional medicine
Abstract:
... Cancer is the second most reason for huge mortality in human life which has attributed to a drastic drift in anticancer drug discovery and development. Small molecules as anticancer agents have contributed tremendously for the treatment of cancer however plants based natural products have the cardinal foundation for traditional medicine schemes and still offer relief to cancer patients. Medicinal ...
DOI:
10.1016/j.prmcm.2022.100123