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You searched for: Subject basic-leucine zipper transcription factors Remove constraint Subject: basic-leucine zipper transcription factors Subject term basic-leucine zipper transcription factors Remove constraint Subject term: basic-leucine zipper transcription factors Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. Genetic, metabolic and immunological features of cancers with NRF2 addiction

Author:
Hiroshi Kitamura; Haruna Takeda; Hozumi Motohashi
Source:
FEBS letters 2022 v.596 no.16 pp. 1981-1993
ISSN:
0014-5793
Subject:
Lewis acids; basic-leucine zipper transcription factors; carcinogenesis; humans; therapeutics
Abstract:
... Nuclear factor erythroid‐derived 2‐like 2 (NRF2) is a master transcription factor that coordinately regulates the expression of many cytoprotective genes and plays a central role in defense mechanisms against oxidative and electrophilic insults. Although increased NRF2 activity is principally beneficial for our health, NRF2 activation in cancer cells is detrimental. Many human cancers exhibit pers ...
DOI:
10.1002/1873-3468.14458

2. Nrf2 attenuates the innate immune response after experimental myocardial infarction

Author:
Daniel I. Bromage; Silvia C. Trevelin; Josef Huntington; Victoria X. Yang; Ananya Muthukumar; Sarah J. Mackie; Greta Sawyer; Xiaohong Zhang; Celio X.C. Santos; Niloufar Safinia; Ioannis Smyrnias; Mauro Giacca; Aleksandar Ivetic; Ajay M. Shah
Source:
Biochemical and biophysical research communications 2022 v.606 pp. 10-16
ISSN:
0006-291X
Subject:
basic-leucine zipper transcription factors; chemokines; coronary vessels; genes; heart; heart failure; inflammation; innate immunity; interleukin-6; macrophages; mice; monocytes; myocardial infarction; phenotype; research; sequence analysis; transcription (genetics)
Abstract:
... There is compelling evidence implicating dysregulated inflammation in the mechanism of ventricular remodeling and heart failure (HF) after MI. The transcription factor nuclear factor erythroid-derived 2-like 2 (Nrf2, encoded by Nfe2l2) is a promising target in this context since it impedes transcriptional upregulation of pro-inflammatory cytokines and is anti-inflammatory in various murine models. ...
DOI:
10.1016/j.bbrc.2022.03.043

3. Quercetin protects human liver cells from o,p’-DDT-induced toxicity by suppressing Nrf2 and NADPH oxidase-regulated ROS production

Author:
Xiangyuan Liu; Li Song
Source:
Food and chemical toxicology 2022 v.161 pp. 112849
ISSN:
0278-6915
Subject:
DDT (pesticide); NAD(P)H oxidase (H2O2-forming); NADP (coenzyme); apoptosis; basic-leucine zipper transcription factors; cell viability; crosslinking; cytotoxicity; genotoxicity; hepatotoxicity; humans; lactate dehydrogenase; liver; membrane potential; metabolites; mitochondrial membrane; quercetin; reactive oxygen species; toxicology
Abstract:
... Epidemiologic studies have revealed that Dichlorodiphenyltrichloroethane (DDT) and its metabolites are associated with liver diseases. However, there has been little emphasis on the mechanism underlying liver toxicity of o,p’-DDT and relevant effective inhibitors investigation. This study indicated o,p’-DDT exposure significantly decreased cell viability and promoted lactate dehydrogenase (LDH) re ...
DOI:
10.1016/j.fct.2022.112849

4. Sulforaphane enhances Nrf2-mediated antioxidant responses of skeletal muscle induced by exhaustive exercise in HIIT mice

Author:
Yangwenjie Wang; Yang Xiang; Ruiqi Wang; Xiangning Li; Jianxiong Wang; Siwang Yu; Ying Zhang
Source:
Food science and human wellness 2022 v.11 no.5 pp. 1355-1361
ISSN:
2213-4530
Subject:
Brassicaceae; antioxidant activity; antioxidants; basic-leucine zipper transcription factors; blood; creatine kinase; exercise; exercise test; food science; humans; males; nucleoproteins; skeletal muscle; sulforaphane
Abstract:
... Nuclear factor erythroid-derived 2-like 2 (Nrf2) is the master regulator of antioxidant defenses. High-intensity interval training (HIIT) has been proposed as a time-efficient training program and has become a substantial component of modern training program. In the present study, we evaluated the effects of sulforaphane (SFN), a dietary isothiocyanate derived from cruciferous vegetables and a pot ...
DOI:
10.1016/j.fshw.2022.04.035

5. Suppression of colonic oxidative stress caused by chronic ethanol administration and attenuation of ethanol-induced colitis and gut leakiness by oral administration of sesaminol in mice

Author:
Hideo Ohira; Daiki Oikawa; Yoichi Kurokawa; Yuichi Aoki; Ayano Omura; Kunio Kiyomoto; Wao Nakagawa; Rie Mamoto; Yoshio Fujioka; Toru Nakayama
Source:
Food & function 2022 v.13 no.18 pp. 9285-9298
ISSN:
2042-650X
Subject:
antioxidants; basic-leucine zipper transcription factors; chemokine CCL2; colitis; colon; colorectal neoplasms; dietary supplements; endotoxins; ethanol; heme oxygenase (biliverdin-producing); inducible nitric oxide synthase; inflammation; interleukin-6; lignans; malondialdehyde; mice; models; necrosis; oral administration; oxidative stress; pathogenesis; rectum; risk; tight junctions; transcription factor NF-kappa B
Abstract:
... Chronic consumption of excess ethanol is one of the major risk factors for colorectal cancer (CRC), and the pathogenesis of ethanol-related CRC (ER-CRC) involves ethanol-induced oxidative-stress and inflammation in the colon and rectum, as well as gut leakiness. In this study, we hypothesised that oral administration of sesaminol, a sesame lignan, lowers the risk of ER-CRC because we found that it ...
DOI:
10.1039/d1fo04120g

6. 18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2

Author:
Boda Chen; Dingchao Zhu; Chenglong Xie; Yifeng Shi; Libin Ni; Huawei Zhang; Sunlong Li; Jiajie Lu; Jian Xiao; Weiyi Xia; Chongan Huang; Xiangyang Wang
Source:
Food & function 2021 v.12 no.18 pp. 8399-8410
ISSN:
2042-650X
Subject:
Glycyrrhiza glabra; basic-leucine zipper transcription factors; bioactive compounds; cartilage; chondrocytes; collagen; extracellular matrix; histology; inducible nitric oxide synthase; inflammation; interleukin-6; matrix metalloproteinase 13; mice; necrosis; neoplasms; nitric oxide; osteoarthritis; prostaglandin synthase; prostaglandins; sclerosis; synovitis; therapeutics; transcription factor NF-kappa B
Abstract:
... Osteoarthritis (OA) is presently the most prevalent form of chronic degenerative joint disease, which is characterized by erosion of articular cartilage, subchondral bone sclerosis and synovitis. Accumulating evidence has revealed that 18β-glycyrrhetinic acid (18β-GA), a major bioactive component derived from Glycyrrhiza glabra, exerts anti-inflammatory effects on several diseases. However, the an ...
DOI:
10.1039/d1fo01379c

7. Adenosine 5′-monophosphate-activated protein kinase ameliorates bovine adipocyte oxidative stress by inducing antioxidant responses and autophagy

Author:
Qiushi Xu; Yunhui Fan; Juan J. Loor; Yusheng Liang; Xudong Sun; Hongdou Jia; Chenxu Zhao; Chuang Xu
Source:
Journal of dairy science 2021 v.104 no.4 pp. 4516-4528
ISSN:
0022-0302
Subject:
Holstein; adenosine; adipocytes; adipose tissue; antioxidant activity; autophagy; basic-leucine zipper transcription factors; blood serum; catalase; dairy science; genes; glutathione peroxidase; glutathione transferase; heme oxygenase (biliverdin-producing); homeostasis; ketosis; malondialdehyde; oxidative stress; protein kinases; superoxide dismutase
Abstract:
... Adipose tissue concentration of reactive oxygen species (ROS) increases in dairy cows with ketosis, suggesting that the tissue experiences oxidative stress. Autophagy, an adaptive response to cellular stress, has been shown to promote survival and plays a critical role in antioxidant responses. Dysregulation of adenosine 5′-monophosphate-activated protein kinase (AMPK) is closely related to antiox ...
DOI:
10.3168/jds.2020-18728

8. Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis

Author:
Chenglong Xie; Haiwei Ma; Yifeng Shi; Junli Li; Hongqiang Wu; Ben Wang; Zhenxuan Shao; Chongan Huang; Jiaoxiang Chen; Liaojun Sun; Yifei Zhou; Naifeng Tian; Yaosen Wu; Weiyang Gao; Aimin Wu; Xiangyang Wang; Xiaolei Zhang
Source:
Food & function 2021 v.12 no.6 pp. 2703-2714
ISSN:
2042-650X
Subject:
Alpinia hainanensis; anti-inflammatory activity; basic-leucine zipper transcription factors; catabolism; chalcone; collagen; degradation; inducible nitric oxide synthase; inflammation; interleukin-6; intervertebral disks; intragastric administration; matrix metalloproteinase 13; models; nitric oxide; pain; prostaglandin synthase; prostaglandins; protective effect; rats; therapeutics; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Intervertebral disc degeneration (IVDD) is one of the major causes of low back pain, but effective therapies are still lacking because of its complicated pathology. It has been demonstrated that increased levels of interleukin-1β (IL-1β) may promote the development of IVDD. Cardamonin (CAR) is a chalcone extracted from Alpinia katsumadai and other plants. It exhibits an anti-inflammatory effect in ...
DOI:
10.1039/d0fo03353g

9. Compatibility with Semen Sojae Praeparatum attenuates hepatotoxicity of Gardeniae Fructus by regulating the microbiota, promoting butyrate production and activating antioxidant response

Author:
Yusha Luo; Xingjie Zhang; Wen Zhang; Qiliang Yang; Wei You; Jun Wen; Tingting Zhou
Source:
Phytomedicine 2021 v.90 pp. 153656
ISSN:
0944-7113
Subject:
Enterococcus; Lactobacillus; Prevotella; Western blotting; antibiotics; antioxidant activity; basic-leucine zipper transcription factors; butyrates; cecum; colon; dysbiosis; gas chromatography-mass spectrometry; hepatotoxicity; histopathology; immunohistochemistry; intestinal microorganisms; lipopolysaccharides; liver; metabolism; metabolites; permeability; protective effect; China
Abstract:
... Herb-induced liver injury is a leading cause of drug-induced liver injury in China and its incidence is also increasing worldwide. Gardeniae Fructus (ZZ) has aroused wide concern for hepatotoxicity in recent decades. But when ZZ is administered in combination with Semen Sojae Praeparatum (DDC) to compose a herbal pair Zhizichi Decoction (ZZCD), lower hepatotoxicity is observed. The mechanism invol ...
DOI:
10.1016/j.phymed.2021.153656

10. Curcumin Suppresses the Lipid Accumulation and Oxidative Stress Induced by Benzo[a]pyrene Toxicity in HepG2 Cells

Author:
Seung-Cheol Lee; Seung-Cheol Jee; Min Kim; Soee Kim; Min Kyoung Shin; Yunkyung Kim; Jung-Suk Sung
Source:
Antioxidants 2021 v.10 no.8 pp. -
ISSN:
2076-3921
Subject:
Curcuma longa; DNA damage; antioxidant activity; aryl hydrocarbon receptors; basic-leucine zipper transcription factors; benzo(a)pyrene; bioactive compounds; carcinogens; cell nucleus; cell viability; curcumin; cytochrome P-450; cytotoxicity; hepatotoxicity; human cell lines; lipemic effect; lipids; metabolic detoxification; oxidative stress; polypeptides; protein denaturation; reactive oxygen species; toxicity testing; turmeric
Abstract:
... Benzo[a]pyrene (B[a]P) is a potentially hepatotoxic group-1 carcinogen taken up by the body through ingestion of daily foods. B[a]P is widely known to cause DNA and protein damages, which are closely related to cell transformation. Accordingly, studies on natural bioactive compounds that attenuate such chemical-induced toxicities have significant impacts on public health. This study aimed to uncov ...
DOI:
10.3390/antiox10081314

11. Ethephon-Induced Ethylene Enhances Starch Degradation and Sucrose Transport with an Interactive Abscisic Acid-Mediated Manner in Mature Leaves of Oilseed rape (Brassica napus L.)

Author:
Bok-Rye Lee; Rashed Zaman; Van Hien La; Dong-Won Bae; Tae-Hwan Kim
Source:
Plants 2021 v.10 no.8 pp. -
ISSN:
2223-7747
Subject:
9-cis-epoxycarotenoid dioxygenase; Brassica napus; abscisic acid; alpha-amylase; basic helix-loop-helix transcription factors; basic-leucine zipper transcription factors; beta-amylase; carbohydrate content; carbohydrate metabolism; cell senescence; chlorophyll; cysteine proteinases; ethephon; ethylene; foliar spraying; gene expression; gene expression regulation; leaf chlorophyll content; leaves; phloem; physiological transport; plant exudates; protein-serine-threonine kinases; rapeseed; senescence (aging); starch; sucrose; transporters
Abstract:
... The leaf senescence process is characterized by the degradation of macromolecules in mature leaves and the remobilization of degradation products via phloem transport. The phytohormone ethylene mediates leaf senescence. This study aimed to investigate the ethephon-induced ethylene effects on starch degradation and sucrose remobilization through their interactive regulation with other hormones. Eth ...
DOI:
10.3390/plants10081670

12. Gallic Acid Improves Diabetic Steatosis by Downregulating MicroRNA-34a-5p through Targeting NFE2L2 Expression in High-Fat Diet-Fed db/db Mice

Author:
Ang-Tse Lee; Mon-Yuan Yang; Yi-Ju Lee; Tzu-Wei Yang; Chi-Chih Wang; Chau-Jong Wang
Source:
Antioxidants 2021 v.11 no.1 pp. -
ISSN:
2076-3921
Subject:
basic-leucine zipper transcription factors; fatty liver; fatty-acid synthase; gallic acid; glucose; high fat diet; lipogenesis; liver; mice; microRNA; microarray technology; noninsulin-dependent diabetes mellitus; oleic acid; palmitic acid; sterols; therapeutics; triacylglycerols
Abstract:
... Type 2 diabetes mellitus (T2DM) has become epidemic worldwide and is strongly associated with nonalcoholic fatty liver disease (NAFLD). The molecular mechanisms of microRNAs in NAFLD and T2DM development and the corresponding therapies remain unclear. We performed microRNA microarray validation to determine whether hepatic miR-34a-5p was significantly upregulated in db/db mice fed with a high-fat ...
DOI:
10.3390/antiox11010092

13. GmCRY1s modulate gibberellin metabolism to regulate soybean shade avoidance in response to reduced blue light

Author:
Xiangguang Lyu; Qican Cheng; Chao Qin; Yinghui Li; Xinying Xu; Ronghuan Ji; Ruolan Mu; Hongyu Li; Tao Zhao; Jun Liu; Yonggang Zhou; Haiyan Li; Guodong Yang; Qingshan Chen; Bin Liu
Source:
Molecular plant 2021 v.14 no.2 pp. 298-314
ISSN:
1674-2052
Subject:
CRISPR-Cas systems; basic-leucine zipper transcription factors; biochemical pathways; blue light; cryptochromes; cultivars; density; far-red light; gene expression; gibberellins; intercropping; lodging; metabolism; mutants; planting; red light; shade; soybeans; stem elongation
Abstract:
... Soybean is an important legume crop that displays the classic shade avoidance syndrome (SAS), including exaggerated stem elongation, which leads to lodging and yield reduction under density farming conditions. Here, we compared the effects of two shade signals, low red light to far-red light ratio (R:FR) and low blue light (LBL), on soybean status and revealed that LBL predominantly induces excess ...
DOI:
10.1016/j.molp.2020.11.016

14. Meta-analysis and experimental validation identified atrazine as a toxicant in the male reproductive system

Author:
Shenhao Zhu; Tongtong Zhang; Yuhao Wang; Xiang Zhou; Shangqian Wang; Zengjun Wang
Source:
Environmental science and pollution research 2021 v.28 no.28 pp. 37482-37497
ISSN:
0944-1344
Subject:
adolescence; animal models; apoptosis; atrazine; basic-leucine zipper transcription factors; caspases; endocrine-disrupting chemicals; epididymis; gene expression; health effects assessments; heme oxygenase (biliverdin-producing); herbicide residues; hormone secretion; meta-analysis; mice; oxidative stress; randomized clinical trials; rats; reproductive toxicology; signal transduction; sperm concentration; sperm motility; sperm quality; systematic review; testes; testosterone; toxicity testing
Abstract:
... Atrazine (ATZ), as a widely used triazine herbicide, is an environmental endocrine disruptor (EDC) that can cause many health problems. Therefore, we conducted this study based on the evidence of rats and mice to figure out the characteristics of ATZ damage to the reproductive system and further evaluate its health effects on the human. PRISMA’s guidelines were followed according to the principles ...
DOI:
10.1007/s11356-021-13396-6

15. Tetrachlorobenzoquinone exposure triggers ferroptosis contributing to its neurotoxicity

Author:
Zixuan Liu; Xuying Lv; Bingwei Yang; Qi Qin; Erqun Song; Yang Song
Source:
Chemosphere 2021 v.264 pp. 128413
ISSN:
0045-6535
Subject:
apoptosis; basic-leucine zipper transcription factors; ferritin; ferroptosis; glutathione; hexachlorobenzene; iron absorption; lipid peroxidation; metabolites; mitochondria; neurotoxicity; pentachlorophenol; phospholipid-hydroperoxide glutathione peroxidase; quinones; reactive oxygen species; wood preservatives
Abstract:
... Halogenated quinones are representative metabolites of persistent organic pollutants. Tetrachlorobenzoquinone (TCBQ) is a reactive metabolite of the widely used fungicide hexachlorobenzene (HCB) and wood preservative pentachlorophenol (PCP). Our previous studies have demonstrated that TCBQ induced neuron-like cell apoptosis in a reactive oxygen species (ROS)-dependent manner. Here, we found that T ...
DOI:
10.1016/j.chemosphere.2020.128413

16. Trehalose induces SQSTM1/p62 expression and enhances lysosomal activity and antioxidative capacity in adipocytes

Author:
Masaki Kobayashi; Hiromine Yasukawa; Tomoya Arikawa; Yusuke Deguchi; Natsumi Mizushima; Misako Sakurai; Shoichi Onishi; Ryoma Tagawa; Yuka Sudo; Naoyuki Okita; Kyohei Higashi; Yoshikazu Higami
Source:
FEBS Open Bio 2021 v.11 no.1 pp. 185-194
ISSN:
2211-5463
Subject:
adipocytes; antioxidant activity; autophagy; basic-leucine zipper transcription factors; cathepsin L; enzyme activity; glucose tolerance; hepatocytes; hypertrophy; oxidative stress; reactive oxygen species; trehalose; white adipose tissue
Abstract:
... Adipocytes, which comprise the majority of white adipose tissue (WAT), are involved in obesity‐related pathology via various mechanisms, including disturbed lysosomal enzymatic activity and accumulation of oxidative stress. Sequestosome 1 (SQSTM1/p62) is an autophagy marker that participates in antioxidative responses via the activation of nuclear factor erythroid‐derived 2‐like 2 (NRF2). Trehalos ...
DOI:
10.1002/2211-5463.13055

17. ABA-dependent bZIP transcription factor, CsbZIP18, from Camellia sinensis negatively regulates freezing tolerance in Arabidopsis

Author:
Lina Yao; Xinyuan Hao; Hongli Cao; Changqing Ding; Yajun Yang; Lu Wang; Xinchao Wang
Source:
Plant cell reports 2020 v.39 no.4 pp. 553-565
ISSN:
0721-7714
Subject:
Arabidopsis; Camellia sinensis; abscisic acid; acclimation; basic-leucine zipper transcription factors; cold; cold stress; cold tolerance; cultivars; electrolyte leakage; freezing; gene overexpression; genes; homeostasis; leucine zipper; photosystem II; signal transduction; stress response; tea
Abstract:
... KEY MESSAGE: Overexpression of the tea plant gene CsbZIP18 in Arabidopsis impaired freezing tolerance, and CsbZIP18 is a negative regulator of ABA signaling and cold stress. Basic region/leucine zipper (bZIP) transcription factors play important roles in the abscisic acid (ABA) signaling pathway and abiotic stress response in plants. However, few bZIP transcription factors have been functionally c ...
DOI:
10.1007/s00299-020-02512-4

18. Asparagus racemosus bZIP transcription factor-regulated squalene epoxidase (ArSQE) promotes germination and abiotic stress tolerance in transgenic tobacco

Author:
Swati Upadhyay; Gajendra Singh Jeena; Sunil Kumar; Rakesh Kumar Shukla
Source:
Plant science 2020 v.290 pp. 110291
ISSN:
0168-9452
Subject:
Asparagus racemosus; abiotic stress; antifungal agents; basic-leucine zipper transcription factors; biosynthesis; chemistry; complement; ergosterol; genetically modified organisms; germination; information; medicinal properties; mutants; promoter regions; seedlings; squalene monooxygenase; steroid saponins; stress response; stress tolerance; tobacco; yeasts
Abstract:
... A. racemosus is a rich source of pharmacologically active steroidal saponins. Most of the studies are related to its chemistry and pharmacology, but the pathway involved in the biosynthesis of steroidal saponin is not much emphasized. Squalene epoxidase acts as a rate-limiting enzyme in this biosynthesis. In this study, we have selected root specific squalene epoxidase ArSQE from A. racemosus for ...
DOI:
10.1016/j.plantsci.2019.110291

19. The CmbZIP1 transcription factor of chrysanthemum negatively regulates shoot branching

Author:
Cunquan Yuan; Jingtian Shi; Liangjun Zhao
Source:
Plant physiology and biochemistry 2020 v.151 pp. 69-76
ISSN:
0981-9428
Subject:
Arabidopsis; Chrysanthemum; auxins; basic-leucine zipper transcription factors; branching; buds; genes; leucine zipper; ornamental plants; shade
Abstract:
... The basic region/leucine zipper (bZIP) transcription factors play key roles in regulating diverse biological processes in plants. However, their participation in shoot branching has been rarely reported. Here, we isolated a CmbZIP1 transcription factor gene, a member of the bZIP family, from chrysanthemum. Subcellular localization analysis indicated that CmbZIP1 is a nuclear protein. Tissue-specif ...
DOI:
10.1016/j.plaphy.2020.03.013

20. Dietary walnut as food factor to rescue from NSAID-induced gastrointestinal mucosal damages

Author:
Jeong Min An; Eun Hye Kim; Hookeun Lee; Ho Jae Lee; Ki Baik Hahm
Source:
Archives of biochemistry and biophysics 2020 v.689 pp. 108466
ISSN:
0003-9861
Subject:
Helicobacter pylori; alcohols; animal models; antioxidant activity; antioxidant enzymes; aspirin; basic-leucine zipper transcription factors; bile; biophysics; carbon monoxide; food intake; gastric acid; glutamate-cysteine ligase; heme oxygenase (biliverdin-producing); iron; quinones; stomach; toxicity; walnuts
Abstract:
... Nuclear factor erythroid-derived 2-like 2 (Nrf-2) is transcription factor implicated in the antioxidant response element-mediated induction of endogenous antioxidant enzyme such as heme oxygenase-1 (HO-1), glutamate-cysteine ligase, and NAD(P)H quinone dehydrogenase 1, among which HO-1 is an enzyme catalyzing the degradation of heme.producing biliverdin, ferrous iron, and carbon monoxide. In the s ...
DOI:
10.1016/j.abb.2020.108466