Subject: basic-leucine zipper transcription factors

1. Predicting specificity in bZIP coiled-coil protein interactions

Author:: Jessica H Fong; Amy E Keating; Mona Singh
Source:: Genome biology 2004 v.5 no.2 pp. 815
ISSN:: 1474-760X
Subject:: basic-leucine zipper transcription factors; genome; humans; prediction; protein-protein interactions; yeasts
Abstract:: ... We present a method for predicting protein-protein interactions mediated by the coiled-coil motif. When tested on interactions between nearly all human and yeast bZIP proteins, our method identifies 70% of strong interactions while maintaining that 92% of predictions are correct. Furthermore, cross-validation testing shows that including the bZIP experimental data significantly improves performanc ...
DOI:: 10.1186/gb-2004-5-2-r11
PubMed:: 14759261
PubMed Central:: PMC395749
: https://doi.org/10.1186/gb-2004-5-2-r11

2. DNA bending by bHLH charge variants

Author:: McDonald, Robert J.; Kahn, Jason D.; Maher, L. James III.
Source:: Nucleic acids research 2006 v.34 no.17 pp. 4846-4856
ISSN:: 0305-1048
Subject:: DNA; amino acids; basic-leucine zipper transcription factors; cations; electrostatic interactions; models; phosphates
Abstract:: ... We wish to understand the role of electrostatics in DNA stiffness and bending. The DNA charge collapse model suggests that mutual electrostatic repulsions between neighboring phosphates significantly contribute to DNA stiffness. According to this model, placement of fixed charges near the negatively charged DNA surface should induce bending through asymmetric reduction or enhancement of these inte ...
DOI:: 10.1093/nar/gkl552
PubMed:: 16973898
PubMed Central:: PMC1635255
: https://doi.org/10.1093/nar/gkl552

3. Cladosporium fulvum CfHNNI1 induces hypersensitive necrosis, defence gene expression and disease resistance in both host and nonhost plants

Author:: Cai, Xin-Zhong; Zhou, Xin; Xu, You-Ping; Joosten, Matthieu H. A. J.; de Wit, Pierre J. G. M.
Source:: Plant molecular biology 2007 v.64 no.1-2 pp. 89-101
ISSN:: 0167-4412
Subject:: Passalora fulva; Phytophthora nicotianae var. parasitica; Potato virus X; Pseudomonas syringae pv. tabaci; Tobacco mosaic virus; basic-leucine zipper transcription factors; cells; complementary DNA; disease resistance; elicitors; gene expression; genes; genetic markers; hypersensitive response; induced resistance; leaves; necrosis; pathogens; tobacco; tomatoes; transgenic plants
Abstract:: ... Nonhost resistance as a durable and broad-spectrum defence strategy is of great potential for agricultural applications. We have previously isolated a cDNA showing homology with genes encoding bZIP transcription factors from tomato leaf mould pathogen Cladosporium fulvum. Upon expression, the cDNA results in necrosis in C. fulvum host tomato and nonhost tobacco plants and is thus named CfHNNI1 (fo ...
DOI:: 10.1007/s11103-007-9136-0
: https://doi.org/10.1007/s11103-007-9136-0

4. Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPβ by GCN5

Author:: Wiper-Bergeron, Nadine; Salem, Houssein Abdou; Tomlinson, Julianna J.; Wu, Dongmei; Haché, Robert J.G.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.8 pp. 2703-2708
ISSN:: 0027-8424
Subject:: acetylation; arginine; basic-leucine zipper transcription factors; cyclic AMP; glucocorticoids; histone deacetylase; insulin; lysine; titration; transcription (genetics)
Abstract:: ... Preadipocyte differentiation in culture is driven by an insulin and cAMP dependant transcriptional cascade which induces the bzip transcription factors C/EBPβ and C/EBPδ. We have previously shown that glucocorticoid treatment, which strongly potentiates this differentiation pathway, stimulates the titration of the corepressor histone deacetylase 1 (HDAC1) from C/EBPβ. This results in a dramatic en ...
DOI:: 10.1073/pnas.0607378104
PubMed:: 17301242
PubMed Central:: PMC1815245
: https://doi.org/10.1073/pnas.0607378104

5. Reconstruction of ancestral protein interaction networks for the bZIP transcription factors

Author:: Pinney, John W.; Amoutzias, Grigoris D.; Rattray, Magnus; Robertson, David L.
Source:: Proceedings of the National Academy of Sciences of the United States of America 2007 v.104 no.51 pp. 20449-20453
ISSN:: 0027-8424
Subject:: basic-leucine zipper transcription factors; data collection; gene duplication; leucine zipper; phylogeny; prediction; probabilistic models; protein-protein interactions; quantitative analysis
Abstract:: ... As whole-genome protein-protein interaction datasets become available for a wide range of species, evolutionary biologists have the opportunity to address some of the unanswered questions surrounding the evolution of these complex systems. Protein interaction networks from divergent organisms may be compared to investigate how gene duplication, deletion, and rewiring processes have shaped the evol ...
DOI:: 10.1073/pnas.0706339104
PubMed:: 18077348
PubMed Central:: PMC2154451
: https://doi.org/10.1073/pnas.0706339104

6. Distinct regions of ATF/CREB proteins Atf1 and Pcr1 control recombination hotspot ade6-M26 and the osmotic stress response

Author:: Gao, Jun; Davidson, Mari K.; Wahls, Wayne P.
Source:: Nucleic acids research 2008 v.36 no.9 pp. 2838-2851
ISSN:: 0305-1048
Subject:: DNA; Schizosaccharomyces pombe; basic-leucine zipper transcription factors; dimerization; meiosis; osmotic stress; stress response
Abstract:: ... The Atf1 protein of Schizosaccharomyces pombe contains a bZIP (DNA-binding/protein dimerization) domain characteristic of ATF/CREB proteins, but no other functional domains or clear homologs have been reported. Atf1-containing, bZIP protein dimers bind to CRE-like DNA sites, regulate numerous stress responses, and activate meiotic recombination at hotspots like ade6-M26. We defined systematically ...
DOI:: 10.1093/nar/gkn037
PubMed:: 18375981
PubMed Central:: PMC2396409
: https://doi.org/10.1093/nar/gkn037

7. Wheat FT protein regulates VRN1 transcription through interactions with FDL2

Author:: Li, Chengxia; Dubcovsky, Jorge
Source:: Plant journal 2008 v.55 no.4 pp. 543-554
ISSN:: 0960-7412
Subject:: Arabidopsis; basic-leucine zipper transcription factors; flowering; genes; leaves; meristems; photoperiod; promoter regions; rice; transcriptional activation; transgenic plants; vernalization; wheat
Abstract:: ... A precise regulation of flowering time is central to plant species survival. Therefore, mechanisms have evolved in plants to integrate various environmental cues to optimize flowering time. In this study, we show that the product of the wheat gene TaFT, which integrates photoperiod and vernalization signals promoting flowering, interacts with bZIP proteins TaFDL2 and TaFDL6. We also show that TaFD ...
DOI:: 10.1111/j.1365-313X.2008.03526.x
PubMed:: 18433437
PubMed Central:: PMC4739743
: https://doi.org/10.1111/j.1365-313X.2008.03526.x

8. A dimer-specific function of the transcription factor NFATp

Author:: Falvo, James V.; Lin, Charles H.; Tsytsykova, Alla V.; Hwang, Peter K.; Thanos, Dimitris; Goldfeld, Anne E.; Maniatis, Tom
Source:: Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.50 pp. 19637-19642
ISSN:: 0027-8424
Subject:: transcriptional activation; tumor necrosis factors; basic-leucine zipper transcription factors; DNA; signal transduction; dimerization; transcription (genetics); binding sites; genes; leucine zipper
Abstract:: ... The transcription factor NFATp integrates multiple signal transduction pathways through coordinate binding with basic-region leucine zipper (bZIP) proteins and other transcription factors. The NFATp monomer, even in the absence of its activation domains, recruits bZIP proteins to canonical NFAT-bZIP composite DNA elements. By contrast, the NFATp dimer and its bZIP partner bind noncooperatively to ...
DOI:: 10.1073/pnas.0810648105
PubMed:: 19060202
PubMed Central:: PMC2604938
: https://doi.org/10.1073/pnas.0810648105

9. The role of ATF-2 in oncogenesis

Author:: Vlahopoulos, Spiros A.; Logotheti, Stella; Mikas, Dimitris; Giarika, Athina; Gorgoulis, Vassilis; Zoumpourlis, Vassilis
Source:: BioEssays 2008 v.30 no.4 pp. 314-327
ISSN:: 0265-9247
Subject:: DNA-binding proteins; animal models; antineoplastic agents; apoptosis; basic-leucine zipper transcription factors; carcinogenesis; cyclins; genes; humans; neoplasms; phenotype; signal transduction; stress response
Abstract:: ... Activating Transcription Factor-2 is a sequence-specific DNA-binding protein that belongs to the bZIP family of proteins and plays diverse roles in the mammalian cells. In response to stress stimuli, it activates a variety of gene targets including cyclin A, cyclin D and c-jun, which are involved in oncogenesis in various tissue types. ATF-2 expression has been correlated with maintenance of a can ...
DOI:: 10.1002/bies.20734
: https://doi.org/10.1002/bies.20734

10. Genetic and spatial interactions between FT, TSF and SVP during the early stages of floral induction in Arabidopsis

Author:: Jang, Seonghoe; Torti, Stefano; Coupland, George
Source:: Plant journal 2009 v.60 no.4 pp. 614-625
ISSN:: 0960-7412
Subject:: Arabidopsis; basic-leucine zipper transcription factors; flowering; flowers; gene overexpression; leaf meristems; loci; messenger RNA; mutants; null alleles; phenotype; phloem companion cells; photoperiod; yeasts
Abstract:: ... Flowering is controlled by a network of pathways that converge to regulate a small number of floral integrator genes. We studied the interactions in Arabidopsis between three of these integrators, FLOWERING LOCUS T (FT), TWIN SISTER OF FT (TSF) and SUPPRESSOR OF OVEREXPRESSION OF CONSTANS 1 (SOC1), as well as their repression by the MADS box transcription factor SHORT VEGETATIVE PHASE (SVP). FT is ...
DOI:: 10.1111/j.1365-313X.2009.03986.x
PubMed:: 19656342
: https://doi.org/10.1111/j.1365-313X.2009.03986.x

11. Tissue-specific expression of the PNZIP promoter is mediated by combinatorial interaction of different cis-elements and a novel transcriptional factor

Author:: Yang, Yu-Tao; Yu, Yan-Li; Yang, Guo-Dong; Zhang, Jie-Dao; Zheng, Cheng-Chao
Source:: Nucleic acids research 2009 v.37 no.8 pp. 2630-2644
ISSN:: 0305-1048
Subject:: Arabidopsis; Northern blotting; abscisic acid; amino acids; basic-leucine zipper transcription factors; biosynthesis; chlorophyll; gene expression; genetically modified organisms; mutation; nucleic acids; reporter genes; screening; tobacco; transcription (genetics); yeasts
Abstract:: ... Recent studies demonstrated that PNZIP and its homologs encode a special cyclase and play an important role in chlorophyll biosynthesis in higher plants. To investigate the molecular mechanism governing the PNZIP gene, the PNZIP promoter was isolated and analyzed. Deletion analysis indicated that G-box is an important element in the regulation of the reporter gene expression. Further mutation assa ...
DOI:: 10.1093/nar/gkp126
PubMed:: 19270069
PubMed Central:: PMC2677881
: https://doi.org/10.1093/nar/gkp126

12. Unique status of NIA2 in nitrate assimilation:NIA2 expression is promoted by HY5/HYH and inhibited by PIF4

Author:: Else Müller Jonassen; Bjørnar AA Sandsmark; Cathrine Lillo
Source:: Plant signaling & behavior 2009 v.4 no.11 pp. 1084-1086
ISSN:: 1559-2324
Subject:: active oxygen species; basic-leucine zipper transcription factors; genes; glutamate synthase (NADPH); glutamate-ammonia ligase; leaves; nitrate reductase; nitrates; nitric oxide; nitrite reductase; nitrites; nitrogen; phytochrome
Abstract:: ... Light perceived by phytochromes will induce genes of nitrogen assimilation, however, transducing components in the signalling cascades to these genes are hardly known. Recently the bZIP transcription factors HY5 (LONG HYPOCOTYL5) and HYH (HOMOLOG OF HY5) were identified as positive regulators in light activation of NIA2 (nitrate reductase 2). The bHLH transcription factor PIF4 (PHYTOCHROME INTERAC ...
DOI:: 10.4161/psb.4.11.9795
PubMed:: 20009559
PubMed Central:: PMC2819521
: https://doi.org/10.4161/psb.4.11.9795

13. Homo- and heterodimers of tobacco bZIP proteins counteract as positive or negative regulators of transcription during pollen development

Author:: Iven, Tim; Strathmann, Anne; Böttner, Stefan; Zwafink, Thomas; Heinekamp, Thorsten; Guivarc'h, Anne; Roitsch, Thomas; Dröge-Laser, Wolfgang
Source:: Plant journal 2010 v.63 no.1 pp. 155-166
ISSN:: 0960-7412
Subject:: Nicotiana tabacum; auxins; basic-leucine zipper transcription factors; beta-fructofuranosidase; enzyme activity; genes; in situ hybridization; leucine zipper; models; pollen; tobacco; transcriptional activation
Abstract:: ... Expression of BZI-1ΔN, a dominant-negative form of the tobacco (Nicotiana tabacum) basic leucine zipper (bZIP) transcription factor BZI-1 leads to severe defects in pollen development which coincides with reduced transcript abundance of the stamen specific invertase gene NIN88 and decreased extracellular invertase enzymatic activity. This finding suggests a function of BZI-1 in regulating carbohyd ...
DOI:: 10.1111/j.1365-313X.2010.04230.x
PubMed:: 20409000
: https://doi.org/10.1111/j.1365-313X.2010.04230.x

14. VIP1: linking Agrobacterium-mediated transformation to plant immunity

Author:: Liu, Yukun; Kong, Xiangpei; Pan, Jiaowen; Li, Dequan
Source:: Plant cell reports 2010 v.29 no.8 pp. 805-812
ISSN:: 0721-7714
Subject:: Agrobacterium radiobacter; agricultural biotechnology; agricultural research; basic-leucine zipper transcription factors; immune response; transgenic plants
Abstract:: ... Agrobacterium tumefaciens is the most efficient vehicle used today for the production of transgenic plants and plays an essential role in basic scientific research and in agricultural biotechnology. Previously, plant VirE2-interacting protein 1 (VIP1) was shown to play a role in Agrobacterium-mediated transformation. Recent reports demonstrate that VIP1, as one of the bZIP transcription factors, i ...
DOI:: 10.1007/s00299-010-0870-4
PubMed:: 20473505
: https://doi.org/10.1007/s00299-010-0870-4

15. Gibberellins negatively regulate low temperature-induced anthocyanin accumulation in a HY5/HYH-dependent manner

Author:: Yongqiang Zhang; Zhongjuan Liu; Rongzhi Liu; Hualing Hao; Yurong Bi
Source:: Plant signaling & behavior 2011 v.6 no.5 pp. 632-634
ISSN:: 1559-2324
Subject:: anthocyanins; basic-leucine zipper transcription factors; biosynthesis; gibberellins; hypocotyls; mutants; temperature
Abstract:: ... Low temperature could significantly induce anthocyanin accumulation in the presence of light. Recently, two bZIP transcription factors LONG HYPOCOTYL 5 (HY5) and HOMOLOG OF HY5 (HYH) were identified to play an important role in the process of low temperature-induced anthocyanin accumulation. However, the mechanism by which HY5/HYH regulates anthocyanin accumulation under low temperature still rema ...
DOI:: 10.4161/psb.6.5.14343
PubMed:: 21636970
PubMed Central:: PMC3172826
: https://doi.org/10.4161/psb.6.5.14343

16. Arabidopsis Clade I TGA Transcription Factors Regulate Plant Defenses in an NPR1-Independent Fashion

Author:: Shearer Heather L.; Cheng Yu Ti; Wang Lipu; Liu Jinman; Boyle Patrick; Després Charles; Zhang Yuelin; Li Xin; Fobert Pierre R.
Source:: Molecular plant-microbe interactions 2012 v.25 no.11 pp. 1459-1468
ISSN:: 0894-0282
Subject:: Arabidopsis; Pseudomonas syringae; basic-leucine zipper transcription factors; disease resistance; genes; microarray technology; mutants; mutation; pathogens; salicylic acid; systemic acquired resistance; transcription (genetics); virulence
Abstract:: ... Transcriptional reprogramming during induction of salicylic acid (SA)-mediated defenses is regulated primarily by NPR1 (NONEXPRESSOR OF PATHOGENESIS-RELATED GENES 1), likely through interactions with TGA bZIP transcription factors. To ascertain the contributions of clade I TGA factors (TGA1 and TGA4) to defense responses, a tga1-1 tga4-1 double mutant was constructed and challenged with Pseudomona ...
DOI:: 10.1094/MPMI-09-11-0256
: https://doi.org/10.1094/MPMI-09-11-0256

17. Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses

Author:: Polly M. Fordyce; David Pincus; Philipp Kimmig; Christopher S. Nelson; Hana El-Samad; Peter Walter; Joseph L. DeRisi
Source:: Proceedings of the National Academy of Sciences of the United States of America 2012 v.109 no.45 pp. E3084
ISSN:: 0027-8424
Subject:: messenger RNA; translation (genetics); unfolded protein response; basic-leucine zipper transcription factors; DNA; gene activation; models; transcription (genetics); genes; leucine zipper
Abstract:: ... A quantitative understanding of how transcription factors interact with genomic target sites is crucial for reconstructing transcriptional networks in vivo. Here, we use Hac1, a well-characterized basic leucine zipper (bZIP) transcription factor involved in the unfolded protein response (UPR) as a model to investigate interactions between bZIP transcription factors and their target sites. During t ...
DOI:: 10.1073/pnas.1212457109
PubMed:: 23054834
PubMed Central:: PMC3494901
: https://doi.org/10.1073/pnas.1212457109

18. Repression of the Arabidopsis thaliana Jasmonic Acid/Ethylene-Induced Defense Pathway by TGA-Interacting Glutaredoxins Depends on Their C-Terminal ALWL Motif

Author:: Mark Zander; Shuxia Chen; Julia Imkampe; Corinna Thurow; Christiane Gatz
Source:: Molecular plant 2012 v.5 no.4 pp. 831-840
Subject:: Arabidopsis thaliana; basic-leucine zipper transcription factors; binding sites; cysteine; ethylene; flowering; genes; glutathione; heat stability; jasmonic acid; oxidoreductases; transcription (genetics)
Abstract:: ... Glutaredoxins are small heat-stable oxidoreductases that transfer electrons from glutathione (GSH) to oxidized cysteine residues, thereby contributing to protein integrity and regulation. In Arabidopsis thaliana , floral glutaredoxins ROXY1 and ROXY2 and pathogen-induced ROXY19/GRX480 interact with bZIP transcription factors of the TGACG (TGA) motif-binding family. ROXY1, ROXY2, and TGA factors PE ...
DOI:: 10.1093/mp/ssr113
: https://doi.org/10.1093/mp/ssr113

19. The bZIP Dimer Localizes at DNA Full-Sites Where Each Basic Region Can Alternately Translocate and Bind to Subsites at the Half-Site

Author:: Chan I-San; Al-Sarraj Taufik; Shahravan S. Hesam; Fedorova Anna V.; Shin Jumi A.
Source:: Biochemistry 2012 v.51 no.33 pp. 6632-6643
ISSN:: 1520-4995
Subject:: DNA; basic-leucine zipper transcription factors; binding capacity; crystal structure; deoxyribonuclease I; gel electrophoresis; leucine zipper; molecular models; regulatory sequences
Abstract:: ... Crystal structures of the GCN4 bZIP (basic region/leucine zipper) with the AP-1 or CRE site show how each GCN4 basic region binds to a 4 bp cognate half-site as a single DNA target; however, this may not always fully describe how bZIP proteins interact with their target sites. Previously, we showed that the GCN4 basic region interacts with all 5 bp in half-site TTGCG (termed 5H-LR) and that 5H-LR ...
DOI:: 10.1021/bi300718f
PubMed:: 22856882
PubMed Central:: PMC3430380
: https://doi.org/10.1021/bi300718f

20. The Arabidopsis NAC Transcription Factor ANAC096 Cooperates with bZIP-Type Transcription Factors in Dehydration and Osmotic Stress Responses

Author:: Zheng-Yi Xu; Soo Youn Kim; Do Young Hyeon; Dae Heon Kim; Ting Dong; Youngmin Park; Jing Bo Jin; Se-Hwan Joo; Seong-Ki Kim; Jong Chan Hong; Daehee Hwang; Inhwan Hwang
Source:: plant cell 2013 v.25 no.11 pp. 4708-4724
ISSN:: 1040-4651
Subject:: Arabidopsis; basic-leucine zipper transcription factors; drought; osmotic stress; osmotic treatment; stress response
Abstract:: ... This work examines the role of the NAC transcription factor ANAC096, finding that ANAC096 interacts with specific bZIP transcription factors to globally affect abscisic acid–responsive transcription during osmotic and drought stresses. ...
DOI:: 10.1105/tpc.113.119099
PubMed:: 24285786
PubMed Central:: PMC3875745
: https://doi.org/10.1105/tpc.113.119099

21. Defects in IRE1 enhance cell death and fail to degrade mRNAs encoding secretory pathway proteins in the Arabidopsis unfolded protein response

Author:: Kei-ichiro Mishiba; Yukihiro Nagashima; Eiji Suzuki; Noriko Hayashi; Yoshiyuki Ogata; Yukihisa Shimada; Nozomu Koizumi
Source:: Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.14 pp. 5713-5718
ISSN:: 0027-8424
Subject:: Animalia; Arabidopsis; actinomycin D; basic-leucine zipper transcription factors; cell death; endoplasmic reticulum; eukaryotic cells; gene expression regulation; genes; heat; heat shock proteins; heat shock response; messenger RNA; microarray technology; mutants; quantitative polymerase chain reaction; signal transduction; tunicamycin; unfolded protein response
Abstract:: ... The unfolded protein response (UPR) is a cellular response highly conserved in eukaryotes to obviate accumulation of misfolded proteins in the endoplasmic reticulum (ER). Inositol-requiring enzyme 1 (IRE1) catalyzes the cytoplasmic splicing of mRNA encoding bZIP transcription factors to activate the UPR signaling pathway. Arabidopsis IRE1 was recently shown to be involved in the cytoplasmic splici ...
DOI:: 10.1073/pnas.1219047110
PubMed:: 23509268
PubMed Central:: PMC3619347
: https://doi.org/10.1073/pnas.1219047110

22. Effect of Flanking Bases on the DNA Specificity of EmBP-1

Author:: De Jong Antonia T.
Source:: Biochemistry 2013 v.52 no.5 pp. 786-794
ISSN:: 1520-4995
Subject:: DNA; alanine; arginine; basic-leucine zipper transcription factors; leucine zipper; lysine; mutants; mutation; nucleotide sequences; oligonucleotides
Abstract:: ... EmBP-1 is a basic region leucine zipper (bZIP) protein found in many types of plants. In general, plant bZIP proteins bind selectively to DNA sequences containing ACGT core sequences with different immediate flanking nucleotides preferred by different proteins. I report that the distant flanking sequence also has a strong effect on the preference of EmBP-1 for internal bases and determine the resi ...
DOI:: 10.1021/bi301404h
: https://doi.org/10.1021/bi301404h

23. Molecular interaction of bZIP domains of GBF1, HY5 and HYH in Arabidopsis seedling development

Author:: Hathi Ram; Sudip Chattopadhyay
Source:: Plant signaling & behavior 2013 v.8 no.1 pp. e22703
ISSN:: 1559-2324
Subject:: Arabidopsis; basic-leucine zipper transcription factors; photomorphogenesis; seedlings
Abstract:: ... The bZIP proteins, GBF1, HY5 and HYH, play important regulatory roles in Arabidopsis seedling development. Whereas GBF1 plays a dual regulatory role, HY5 and HYH act as positive regulators of photomorphogenesis. The molecular and functional relations of GBF1 with HY5 and HYH in photomorphogenesis have recently been demonstrated. However, the possible interaction of bZIP domain of each of these pro ...
DOI:: 10.4161/psb.22703
PubMed:: 23123453
PubMed Central:: PMC3745573
: https://doi.org/10.4161/psb.22703

24. Punctum on two different transcription factors regulated by PGC-1α: Nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2

Author:: Sara Baldelli; Katia Aquilano; Maria R. Ciriolo
Source:: BBA - General Subjects 2013 v.1830 pp. 4137-4146
ISSN:: 0304-4165
Subject:: antioxidants; basic-leucine zipper transcription factors; binding proteins; databases; genes; humans; longevity; mitochondrial DNA; oxidative stress; signal transduction; transcription (genetics)
Abstract:: ... The transcription factor nuclear factor-erythroid-derived 2-like 2 (official symbol: NFE2L2, alias: Nrf2) is a master regulator of antioxidant defense system, which makes it an attractive target for manipulations that aim to increase cellular resistance to oxidative stress. Nuclear respiratory factor 2 or GA binding protein transcription factor alpha (official symbol: GABPA, alias: NRF2) functions ...
DOI:: 10.1016/j.bbagen.2013.04.006
: https://doi.org/10.1016/j.bbagen.2013.04.006

25. Specificity determinants for the abscisic acid response element

Author:: Aditya Kumar Sarkar; Ansuman Lahiri
Source:: FEBS Open Bio 2013 v.3 pp. 101-105
ISSN:: 2211-5463
Subject:: Arabidopsis thaliana; DNA; Gibbs free energy; abscisic acid; algorithms; basic-leucine zipper transcription factors; genes; response elements
Abstract:: ... Abscisic acid (ABA) response elements (ABREs) are a group of cis-acting DNA elements that have been identified from promoter analysis of many ABA-regulated genes in plants. We are interested in understanding the mechanism of binding specificity between ABREs and a class of bZIP transcription factors known as ABRE binding factors (ABFs). In this work, we have modeled the homodimeric structure of th ...
DOI:: 10.1016/j.fob.2013.01.006
PubMed:: 23772380
PubMed Central:: PMC3668542
: https://doi.org/10.1016/j.fob.2013.01.006

26. The Interaction of the Arabidopsis Response Regulator ARR18 with bZIP63 Mediates the Regulation of PROLINE DEHYDROGENASE Expression

Author:: Manikandan Veerabagu; Tobias Kirchler; Kirstin Elgass; Bettina Stadelhofer; Mark Stahl; Klaus Harter; Virtudes Mira-Rodado; Christina Chaban
Source:: Molecular plant 2014 v.7 no.10 pp. 1560-1577
ISSN:: 1674-2052
Subject:: Arabidopsis thaliana; aspartic acid; basic-leucine zipper transcription factors; histidine kinase; osmotic stress; phosphorylation; plant stress; proline; protoplasts; reporter genes; seeds; stress response; transcription (genetics); water stress
Abstract:: ... As the first and rate-limiting enzyme of proline degradation, PROLINE DEHYDROGENASE1 (PDH1) is tightly regulated during plant stress responses, including induction under hypoosmolarity and repression under water deficit. The plant receptor histidine kinases AHKs, elements of the two-component system (TCS) in Arabidopsis thaliana, are proposed to function in water stress responses by regulating dif ...
DOI:: 10.1093/mp/ssu074
: https://doi.org/10.1093/mp/ssu074

27. Multifunctional pentacyclic triterpenoids as adjuvants in cancer chemotherapy: a review

Author:: Sarika M. Kamble; Sameer N. Goyal; Chandragouda R. Patil
Source:: RSC advances 2014 v.4 no.63 pp. 33370-33382
ISSN:: 2046-2069
Subject:: adjuvants; antineoplastic activity; antineoplastic agents; basic-leucine zipper transcription factors; chemoprevention; cost effectiveness; cytotoxicity; drug therapy; free radical scavengers; longevity; neoplasm cells; neoplasms; patients; protein kinase C; quality of life; transcription factor NF-kappa B; triterpenoids
Abstract:: ... Chemotherapeutic agents are a mainstay in the treatment of cancer. However, the nonselectivity of cytotoxic anticancer agents results in multiorgan toxicities. Cancer chemotherapy is often associated with toxicities, which can be expensive to manage and may affect the patient quality of life. Very few organ-protective agents like amifostine are proved as adjuvants to cancer chemotherapy. Amifostin ...
DOI:: 10.1039/c4ra02784a
: https://doi.org/10.1039/c4ra02784a

28. Transcriptional circuitry underlying seed coat development in Arabidopsis

Author:: Deirdre Khan; Jenna L. Millar; Ian J. Girard; Mark F. Belmonte
Source:: Plant science 2014 v.219-220 pp. 51-60
ISSN:: 0168-9452
Subject:: Arabidopsis thaliana; DNA; basic-leucine zipper transcription factors; cell walls; cluster analysis; morphogenesis; nucleotide sequences; seed coat; seed development; starch; transcription (genetics); transcriptomics
Abstract:: ... We analyzed two sub-regions of the maternal seed coat, chalazal (CZSC) and distal (SC), using transcriptomic and histological analyses in the model plant Arabidopsis thaliana. Hierarchical clustering analysis showed that the CZSC and SC are transcriptionally distinct, though the two sub-regions are more similar during early stages of seed development. Robust statistical and network analysis reveal ...
DOI:: 10.1016/j.plantsci.2014.01.004
: https://doi.org/10.1016/j.plantsci.2014.01.004

29. Transcriptome analysis of newly classified bZIP transcription factors of Brassica rapa in cold stress response

Author:: Indeok Hwang; Hee-Jeong Jung; Jong-In Park; Tae-Jin Yang; Ill-Sup Nou
Source:: Genomics 2014 v.104 pp. 194-202
ISSN:: 0888-7543
Subject:: Arabidopsis thaliana; Brassica rapa; amino acids; basic-leucine zipper transcription factors; cold shock response; cold stress; cold treatment; genes; growth and development; inbred lines; microarray technology; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; transcription (genetics); transcriptomics
Abstract:: ... Plant bZIP transcription factors play crucial roles in biological processes. In this study, 136 putative bZIP transcription members were identified in Brassica rapa. The bZIP family can be divided into nine groups according to the specific amino acid rich domain in B. rapa and Arabidopsis thaliana. To screen the cold stress responsive BrbZIP genes, we evaluated whether the transcription patterns o ...
DOI:: 10.1016/j.ygeno.2014.07.008
: https://doi.org/10.1016/j.ygeno.2014.07.008

30. A tandem affinity purification tag of TGA2 for isolation of interacting proteins in Arabidopsis thaliana

Author:: Henrik U Stotz; Simone Findling; Ella Nukarinen; Wolfram Weckwerth; Martin J Mueller; Susanne Berger
Source:: Plant signaling & behavior 2014 v.9 no.10 pp. e972794
ISSN:: 1559-2324
Subject:: Arabidopsis thaliana; basic-leucine zipper transcription factors; ethylene; gene expression; mass spectrometry; molecular weight; mutants; oxylipins; peptides; purification methods; salicylic acid; screening; signal transduction; xenobiotics; yeasts
Abstract:: ... Tandem affinity purification (TAP) tagging provides a powerful tool for isolating interacting proteins in vivo. TAP-tag purification offers particular advantages for the identification of stimulus-induced protein interactions. Type II bZIP transcription factors (TGA2, TGA5 and TGA6) play key roles in pathways that control salicylic acid, ethylene, xenobiotic and reactive oxylipin signaling. Althou ...
DOI:: 10.4161/15592316.2014.972794
PubMed:: 25482810
PubMed Central:: PMC4622720
: https://doi.org/10.4161/15592316.2014.972794

31. Cocoa intake ameliorates hepatic oxidative stress in young Zucker diabetic fatty rats

Author:: Isabel Cordero-Herrera; María Ángeles Martín; Luis Goya; Sonia Ramos
Source:: Food research international 2015 v.69 pp. 194-201
ISSN:: 0963-9969
Subject:: reactive oxygen species; noninsulin-dependent diabetes mellitus; body weight changes; oxidative stress; glutathione; heme oxygenase (biliverdin-producing); glucose; glutathione transferase; males; insulin resistance; hyperglycemia; cocoa products; superoxide dismutase; insulin; rats; glucose tolerance; hepatocytes; diet; liver; glutathione-disulfide reductase; catalase; basic-leucine zipper transcription factors; glutathione peroxidase
Abstract:: ... Chronic hyperglycemia in diabetes is associated with oxidative stress-mediated tissue damage. The present study is aimed to explore the role of a cocoa-enriched diet in ameliorating the oxidative stress-induced damage in the liver of young type 2 diabetic Zucker diabetic fatty (ZDF) rats. Male ZDF rats were fed a control or cocoa-rich diet (10%), and Zucker Lean (ZL) animals received the control d ...
DOI:: 10.1016/j.foodres.2014.12.039
: https://doi.org/10.1016/j.foodres.2014.12.039

32. Dieckol enhances the expression of antioxidant and detoxifying enzymes by the activation of Nrf2–MAPK signalling pathway in HepG2 cells

Author:: Min-Sup Lee; Bonggi Lee; Kyoung-Eun Park; Tadanobu Utsuki; Taisun Shin; Chul Woong Oh; Hyeung-Rak Kim
Source:: Food chemistry 2015 v.174 pp. 538-546
ISSN:: 0308-8146
Subject:: NAD (coenzyme); glutathione; human cell lines; liver; heme oxygenase (biliverdin-producing); basic-leucine zipper transcription factors; glutathione transferase; enzyme activity; hydrogen peroxide; antineoplastic activity; mitogen-activated protein kinase; signal transduction; transcription (genetics); mice; in vitro studies; antioxidant activity
Abstract:: ... Dieckol was previously reported to exhibit antioxidant and anticancer activities in vitro studies. In this study, we characterised the mechanism underlying the dieckol-mediated expression of antioxidant and detoxifying enzymes. Dieckol suppressed the production of intracellular reactive oxygen species in the presence or absence of H2O2 and increased glutathione level in HepG2 cells. Dieckol enhanc ...
DOI:: 10.1016/j.foodchem.2014.11.090
: https://doi.org/10.1016/j.foodchem.2014.11.090

33. Differential expression of four soybean bZIP genes during Phakopsora pachyrhizi infection

Author:: Murilo S. Alves; Zamira G. Soares; Pedro M. P. Vidigal; Everaldo G. Barros; Adriana M. P. Poddanosqui; Luciano N. Aoyagi; Ricardo V. Abdelnoor; Francismar C. Marcelino-Guimarães; Luciano G. Fietto
Source:: Functional & integrative genomics 2015 v.15 no.6 pp. 685-696
ISSN:: 1438-793X
Subject:: soybean rust; Glycine max; transcriptional activation; basic-leucine zipper transcription factors; yeasts; phylogeny; soybeans; Phakopsora pachyrhizi; gene expression; genes; genotype; leucine zipper; agribusiness; pathogens; hormones
Abstract:: ... Asian soybean rust (ASR), caused by the obligate biotrophic fungus Phakopsora pachyrhizi, is one of most important diseases in the soybean (Glycine max (L.) Merr.) agribusiness. The identification and characterization of genes related to plant defense responses to fungal infection are essential to develop ASR-resistant plants. In this work, we describe four soybean genes, GmbZIP62, GmbZIP105, GmbZ ...
DOI:: 10.1007/s10142-015-0445-0
: https://doi.org/10.1007/s10142-015-0445-0

34. Factorial combinations of protein interactions generate a multiplicity of florigen activation complexes in wheat and barley

Author:: Chengxia Li; Huiqiong Lin; Jorge Dubcovsky
Source:: plant journal 2015 v.84 no.1 pp. 70-82
ISSN:: 0960-7412
Subject:: apical meristems; barley; flowering; loci; assays; basic-leucine zipper transcription factors; DNA; fluorescence; wheat; gene expression; amino acids; cytoplasm; genes; florigen; leaves; shoots
Abstract:: ... The FLOWERING LOCUS T (FT) protein is a central component of a mobile flowering signal (florigen) that is transported from leaves to the shoot apical meristem (SAM). Two FT monomers and two DNA‐binding bZIP transcription factors interact with a dimeric 14‐3‐3 protein bridge to form a hexameric protein complex. This complex, designated as the ‘florigen activation complex’ (FAC), plays a critical ro ...
DOI:: 10.1111/tpj.12960
PubMed:: 26252567
PubMed Central:: PMC5104200
CHORUS:: 10.1111/tpj.12960
: https://doi.org/10.1111/tpj.12960

35. Genome-wide identification, expression profiling, and SSR marker development of the bZIP transcription factor family in Medicago truncatula

Author:: Zhengshe Zhang; Wenxian Liu; Xiao Qi; Zhipeng Liu; Wengang Xie; Yanrong Wang
Source:: Biochemical systematics and ecology 2015 v.61 pp. 218-228
ISSN:: 0305-1978
Subject:: cultivars; grasses; flowering; microsatellite repeats; loci; basic-leucine zipper transcription factors; phylogeny; alfalfa; amino acid sequences; gene duplication; transcription (genetics); leucine zipper; seed maturation; Medicago truncatula; exons; introns; pathogens
Abstract:: ... The basic leucine zipper (bZIP) transcription factors have been shown to play great roles in pathogen defense, light and stress signalling, seed maturation and flower development in plants. However, no reports about this transcription factor family have been reported in grass species, including the model dicotyledonous grass species Medicago truncatula. In the present study, we have identified 75 ...
DOI:: 10.1016/j.bse.2015.06.025
: https://doi.org/10.1016/j.bse.2015.06.025

36. Transcriptional regulation of secretory capacity by bZip transcription factors

Author:: Rebecca M. Fox; Deborah J. Andrew
Source:: Frontiers in biology 2015 v.10 no.1 pp. 28-51
ISSN:: 1674-7984
Subject:: unfolded protein response; invertebrates; basic-leucine zipper transcription factors; stress response; vertebrates; transcription (genetics); secretory granules; genes; cell differentiation; cell cycle; endoplasmic reticulum; Golgi apparatus
Abstract:: ... Cells of specialized secretory organs expand their secretory pathways to accommodate the increased protein load necessary for their function. The endoplasmic reticulum (ER), the Golgi apparatus and the secretory vesicles, expand not only the membrane components but also the protein machinery required for increased protein production and transport. Increased protein load causes an ER stress respons ...
DOI:: 10.1007/s11515-014-1338-7
PubMed:: 25821458
PubMed Central:: PMC4374484
: https://doi.org/10.1007/s11515-014-1338-7

37. Transcriptome Profiling of Wild Arachis from Water-Limited Environments Uncovers Drought Tolerance Candidate Genes

Author:: Ana C. M. Brasileiro; Carolina V. Morgante; Ana C. G. Araujo; Soraya C. M. Leal-Bertioli; Amanda K. Silva; Andressa C. Q. Martins; Christina C. Vinson; Candice M. R. Santos; Orzenil Bonfim; Roberto C. Togawa; Mario A. P. Saraiva; David J. Bertioli; Patricia M. Guimaraes
Source:: Plant molecular biology reporter 2015 v.33 no.6 pp. 1876-1892
ISSN:: 0735-9640
Subject:: Arachis hypogaea; alleles; basic-leucine zipper transcription factors; breeding; complementary DNA; drought; drought tolerance; gene expression; gene expression regulation; genetic markers; genetic variation; leaves; nitrilase; peanuts; quantitative polymerase chain reaction; rehydration; reverse transcriptase polymerase chain reaction; roots; soil water deficit; suppression subtractive hybridization; transcriptome; transcriptomics; water stress; wild relatives
Abstract:: ... Peanut (Arachis hypogaea L.) is an important legume cultivated mostly in drought-prone areas where its productivity can be limited by water scarcity. The development of more drought-tolerant varieties is, therefore, a priority for peanut breeding programs worldwide. In contrast to cultivated peanut, wild relatives have a broader genetic diversity and constitute a rich source of resistance/toleranc ...
DOI:: 10.1007/s11105-015-0882-x
PubMed:: 26752807
PubMed Central:: PMC4695501
: https://doi.org/10.1007/s11105-015-0882-x

38. The bZIP transcription factor PfZipA regulates secondary metabolism and oxidative stress response in the plant endophytic fungus Pestalotiopsis fici

Author:: Xiuna Wang; Fan Wu; Ling Liu; Xingzhong Liu; Yongsheng Che; Nancy P. Keller; Liyun Guo; Wen-Bing Yin
Source:: Fungal genetics and biology 2015 v.81 pp. 221-228
ISSN:: 1087-1845
Subject:: Aspergillus nidulans; Pestalotiopsis; aerobiosis; basic-leucine zipper transcription factors; endophytes; eukaryotic cells; fungi; genome; hydrogen peroxide; menadione; mutants; oxidants; oxidative stress; plant response; secondary metabolites; sodium bisulfite; stress response
Abstract:: ... The bZIP transcription factors are conserved in all eukaryotes and play critical roles in organismal responses to environmental challenges. In filamentous fungi, several lines of evidence indicate that secondary metabolism (SM) is associated with oxidative stress mediated by bZIP proteins. Here we uncover a connection with a bZIP protein and oxidative stress induction of SM in the plant endophytic ...
DOI:: 10.1016/j.fgb.2015.03.010
: https://doi.org/10.1016/j.fgb.2015.03.010

39. ABA-HYPERSENSITIVE BTB/POZ PROTEIN 1 functions as a negative regulator in ABA-mediated inhibition of germination in Arabidopsis

Author:: Hani Kim; Soon-Hee Kim; Dong Hye Seo; Sunglan Chung; Sang-Woo Kim; Jeong-Soo Lee; Woo Taek Kim; Jae-Hoon Lee
Source:: Plant molecular biology 2016 v.90 no.3 pp. 303-315
ISSN:: 0167-4412
Subject:: Arabidopsis; abscisic acid; basic-leucine zipper transcription factors; drought; gene expression regulation; genes; germination; mannitol; receptors; root growth; seed development; seedlings; seeds; sodium chloride
Abstract:: ... To elucidate the contribution of CRL3–ABA-mediated responses, we attempted to find CRL3 substrate receptors involved in ABA signaling. One gene named ABA-HYPERSENSITIVE BTB/POZ PROTEIN 1 (AHT1) was upregulated more than 2.5 times by ABA, and its coding region possessed a BTB/POZ domain, which is the common feature of CRL3 substrate receptors. Loss of AHT1 led to retardation of the germination proc ...
DOI:: 10.1007/s11103-015-0418-7
: https://doi.org/10.1007/s11103-015-0418-7

40. Abscisic acid‐induced gene expression in the liverwort Marchantia polymorpha is mediated by evolutionarily conserved promoter elements

Author:: Totan K. Ghosh; Midori Kaneko; Khaleda Akter; Shuhei Murai; Kenji Komatsu; Kimitsune Ishizaki; Katsuyuki T. Yamato; Takayuki Kohchi; Daisuke Takezawa
Source:: Physiologia plantarum 2016 v.156 no.4 pp. 407-420
ISSN:: 0031-9317
Subject:: embryophytes; stomata; genetically modified organisms; gametophytes; ancestry; basic-leucine zipper transcription factors; mosses and liverworts; wheat; gene expression; dormancy; cultured cells; thallus; Marchantia polymorpha; reporter genes; abscisic acid; Angiospermae; promoter regions; beta-glucuronidase
Abstract:: ... Abscisic acid (ABA) is a phytohormone widely distributed among members of the land plant lineage (Embryophyta), regulating dormancy, stomata closure and tolerance to environmental stresses. In angiosperms (Magnoliophyta), ABA‐induced gene expression is mediated by promoter elements such as the G‐box‐like ACGT‐core motifs recognized by bZIP transcription factors. In contrast, the mode of regulation ...
DOI:: 10.1111/ppl.12385
: https://doi.org/10.1111/ppl.12385

41. Analysis of basic leucine zipper genes and their expression during bud dormancy in peach (Prunus persica)

Author:: Ming-Yue Sun; Xi-Ling Fu; Qiu-Ping Tan; Li Liu; Min Chen; Cui-Ying Zhu; Ling Li; Xiu-De Chen; Dong-Sheng Gao
Source:: Plant physiology and biochemistry 2016 v.104 pp. 54-70
ISSN:: 0981-9428
Subject:: quantitative polymerase chain reaction; winter; peaches; basic-leucine zipper transcription factors; microarray technology; eukaryotic cells; reverse transcriptase polymerase chain reaction; dimerization; introns; gene expression; transcription (genetics); Prunus persica; leucine zipper; dormancy; exons; fruit trees; cold
Abstract:: ... Dormancy is a biological characteristic developed to resist the cold conditions in winter. The bZIP transcription factors are present exclusively in eukaryotes and have been identified and classified in many species. bZIP proteins are known to regulate numerous biological processes, however, the role of bZIP in bud dodormancy has not been studied extensively. In total, 50 PpbZIP transcription fact ...
DOI:: 10.1016/j.plaphy.2016.03.004
: https://doi.org/10.1016/j.plaphy.2016.03.004

42. Antidepressant-like activity of red wine phenolic extracts in repeated corticosterone-induced depression mice via BDNF/TrkB/CREB signaling pathway

Author:: Jia Ying; Dong Ziyuan; Yan Tingxu; Wu Bo; Liao Zhengzheng; Bi Kaishun; Gong Ping; Suna Baoshan
Source:: BIO web of conferences 2016 v.7 pp. 04009
ISSN:: 2117-4458
Subject:: animal models; antidepressants; basic-leucine zipper transcription factors; carbohydrate intake; corticosterone; enzyme inhibitors; forced swimming test; hippocampus; mental depression; mice; neurotrophins; phenolic compounds; prefrontal cortex; protein phosphorylation; red wines; signal transduction; sucrose
Abstract:: ... The aim of this study was to investigate the antidepressant-like effect of red wine phenolic extracts in mouse model exposed to exogenous corticosterone. The results showed that 3-week corticosterone injections caused depression-like behavior in mice, as indicated by the significant decrease in sucrose consumption and increase immobility time in the forced swim test. Red wine phenolic extracts tre ...
DOI:: 10.1051/bioconf/20160704009
: https://doi.org/10.1051/bioconf/20160704009

43. Ectopically expressed glutaredoxin ROXY19 negatively regulates the detoxification pathway in Arabidopsis thaliana

Author:: Li-Jun Huang; Ning Li; Corinna Thurow; Markus Wirtz; Rüdiger Hell; Christiane Gatz
Source:: BMC plant biology 2016 v.16 no.1 pp. 200
ISSN:: 1471-2229
Subject:: Arabidopsis thaliana; active sites; basic-leucine zipper transcription factors; disulfide bonds; embryophytes; genes; glutathione; mutants; phenotype; sulfur; transcription (genetics)
Abstract:: ... BACKGROUND: Glutaredoxins (GRXs) are small proteins which bind glutathione to either reduce disulfide bonds or to coordinate iron sulfur clusters. Whereas these well-established functions are associated with ubiquitously occurring GRXs that encode variants of a CPYC or a CGFS motif in the active center, land plants also possess CCxC/S-type GRXs (named ROXYs) for which the biochemical functions are ...
DOI:: 10.1186/s12870-016-0886-1
PubMed:: 27624344
PubMed Central:: PMC5022239
: https://doi.org/10.1186/s12870-016-0886-1

44. Functional Relationship of GBF1 with HY5 and HYH in Genome-Wide Gene Expression in Arabidopsis

Author:: Hathi Ram; Mukesh Jain; Aparna Singh; Sudip Chattopadhyay
Source:: Plant molecular biology reporter 2016 v.34 no.1 pp. 211-220
ISSN:: 0735-9640
Subject:: Arabidopsis; DNA; basic-leucine zipper transcription factors; gene expression; genes; microarray technology; mutants; photomorphogenesis; quantitative polymerase chain reaction; transcription (genetics); transcriptome
Abstract:: ... Transcriptional networks play important roles in the regulation of biological processes through coordinated activation or repression of downstream target genes. Arabidopsis bZIP transcription factors, GBF1, HY5, and HYH, interact and heterodimerize with each other to form the regulatory network in photomorphogenesis. The genome-wide direct target genes of GBF1 and the roles of HY5 and HYH in contr ...
DOI:: 10.1007/s11105-015-0910-x
: https://doi.org/10.1007/s11105-015-0910-x

45. Genome-wide identification and expression analysis of the bZIP gene family in apple (Malus domestica)

Author:: Yuan-Yuan Li; Dong Meng; Mingjun Li; Lailiang Cheng
Source:: Tree genetics & genomes 2016 v.12 no.4 pp. 82
ISSN:: 1614-2942
Subject:: Malus domestica; apples; basic-leucine zipper transcription factors; drought; fruiting; gene expression regulation; genes; growth and development; leaves; leucine zipper; models; plant growth; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; roots; salt stress; stress response; stress tolerance; transcription (genetics)
Abstract:: ... The basic leucine zipper (bZIP) family is one of the largest transcription factor (TF) families in plants, which play crucial roles in plant growth and development. bZIP proteins are involved in multiple biological processes, as well as responses to various biotic/abiotic stresses. Although genome-wide analysis of the bZIP gene family has been conducted in several plant species, only few comprehen ...
DOI:: 10.1007/s11295-016-1043-6
: https://doi.org/10.1007/s11295-016-1043-6

46. Isolation of three B-box zinc finger proteins that interact with STF1 and COP1 defines a HY5/COP1 interaction network involved in light control of development in soybean

Author:: Su Young Shin; Seong Hee Kim; Hye Jin Kim; Su Jeong Jeon; Soon Ae Sim; Gyeong Ryul Ryu; Cheol Min Yoo; Yong Hwa Cheong; Jong Chan Hong
Source:: Biochemical and biophysical research communications 2016 v.478 pp. 1080-1086
ISSN:: 0006-291X
Subject:: Arabidopsis; amino acid deletion; amino acids; basic-leucine zipper transcription factors; complementary DNA; gene expression; leucine zipper; mutants; phenotype; photomorphogenesis; salt tolerance; soybeans; two hybrid system techniques; ubiquitin-protein ligase; zinc finger motif
Abstract:: ... LONG HYPOCOTYL5 (HY5) and STF1 (Soybean TGACG-motif binding Factor 1) are two related bZIP transcription factors that play a positive role in photomorphogenesis and hormonal signaling. In this study, we compared full length STF1 and truncated STF1 overexpression lines and found that the C-terminal 133 amino acids (194–306) possess all the HY5-like function in Arabidopsis. The STF1-DC1 mutant (1–30 ...
DOI:: 10.1016/j.bbrc.2016.08.069
: https://doi.org/10.1016/j.bbrc.2016.08.069

47. MafB, a target of microRNA-155, regulates dendritic cell maturation

Author:: Lu Yang; Rui Li; Shaoxun Xiang; Weihua Xiao
Source:: Open life sciences 2016 v.11 no.1 pp. 46-54
ISSN:: 2391-5412
Subject:: 3' untranslated regions; basic-leucine zipper transcription factors; dendritic cells; gene overexpression; leucine zipper; luciferase; macrophages; phenotype; transcription (genetics)
Abstract:: ... MafB is a member of bZip transcription factors that share similar basic region/leucine zipper DNA binding motifs and N-terminal activation domains. It is well known that MafB is highly expressed in macrophages and promotes differentiation of myeloid progenitors into macrophage. However, little is known about its function in dendritic cells. Here, we report that MafB, as a target of miR-155, which ...
DOI:: 10.1515/biol-2016-0006
: https://doi.org/10.1515/biol-2016-0006

48. Physiological characterization of drought stress response and expression of two transcription factors and two LEA genes in three Prunus genotypes

Author:: Beatriz Bielsa; Carmen Leida; María José Rubio-Cabetas
Source:: Scientia horticulturae 2016 v.213 pp. 260-269
ISSN:: 0304-4238
Subject:: Prunus; abscisic acid; basic-leucine zipper transcription factors; biomarkers; biosynthesis; container-grown plants; crop production; dehydrins; drought; genes; genotype; global warming; hybrids; leaf water potential; phloem; progeny; quantitative polymerase chain reaction; rain; reverse transcriptase polymerase chain reaction; roots; rootstocks; soil; stomatal conductance; stress response; transcription (genetics); water resources; water stress; zinc finger motif; Mediterranean region
Abstract:: ... Global warming has led to a progressive decrease in rainfall, which is reflected by a reduction of water resources in the soil and a negative effect on crop production in Mediterranean areas. Under drought stress, many plants react by inducing a different series of responses at both physiological and molecular levels, allowing them to survive for a variable period of time. Therefore, in order to u ...
DOI:: 10.1016/j.scienta.2016.11.006
: https://doi.org/10.1016/j.scienta.2016.11.006

49. Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling

Author:: Chuanyang Su; Qiong Shi; Xiufang Song; Juanli Fu; Zixuan Liu; Yawen Wang; Yuxin Wang; Xiaomin Xia; Erqun Song; Yang Song
Source:: Toxicology 2016 pp. -
ISSN:: 0300-483X
Subject:: crosslinking; messenger RNA; ubiquitination; pentachlorophenol; oxidative stress; basic-leucine zipper transcription factors; mitogen-activated protein kinase; physiological transport; reactive oxygen species; tyrosine; phosphorylation; metabolites
Abstract:: ... Our previous studies demonstrated that tetrachlorobenzoquinone (TCBQ), an active metabolite of pentachlorophenol, has effects on the generation of reactive oxygen species (ROS) and oxidative stress in vitro and in vivo. Nuclear factor erythroid-derived 2-like 2 (Nrf2) is a cellular sensor of electrophilic or oxidative stress that regulates the expression of antioxidant enzymes and defensive protei ...
DOI:: 10.1016/j.tox.2016.07.002
: https://doi.org/10.1016/j.tox.2016.07.002

50. VIP1 is very important/interesting protein 1 regulating touch responses of Arabidopsis

Author:: Daisuke Tsugama; Shenkui Liu; Tetsuo Takano
Source:: Plant signaling & behavior 2016 v.11 no.6 pp. e1187358
ISSN:: 1559-2324
Subject:: Arabidopsis thaliana; auxins; basic-leucine zipper transcription factors; cytoplasm; gene overexpression; genes; root cap
Abstract:: ... VIP1 (VIRE2-INTERACTING PROTEIN 1) is a bZIP transcription factor in Arabidopsis thaliana. VIP1 and its close homologs (i.e., Arabidopsis group I bZIP proteins) are present in the cytoplasm under steady conditions, but are transiently localized to the nucleus when cells are exposed to hypo-osmotic conditions, which mimic mechanical stimuli such as touch. Recently we have reported that overexpressi ...
DOI:: 10.1080/15592324.2016.1187358
PubMed:: 27171129
PubMed Central:: PMC4973795
: https://doi.org/10.1080/15592324.2016.1187358

51. Abscisic acid: A key regulator of abiotic stress tolerance in plants

Author:: Niyaz A. Dar; Insha Amin; Wasia Wani; Shafiq A. Wani; Asif B. Shikari; Shabir H. Wani; Khalid Z. Masoodi
Source:: Plant gene 2017 v.11 pp. 106-111
ISSN:: 2352-4073
Subject:: abscisic acid; basic-leucine zipper transcription factors; crops; defense mechanisms; dehydrins; drought tolerance; embryogenesis; gene expression; genes; genetic engineering; osmotic stress; plant stress; promoter regions; salinity; signal transduction; stomatal movement; stress response; stress tolerance; transcription (genetics)
Abstract:: ... Phytohormones are key-regulators mediating environmental stress-responses and are the potential candidates for genetic manipulation to obtain abiotic stress tolerant crops. Plant stress responses occur through various signal transduction networks involving transcription factors regulating abscisic acid (ABA) signaling. The transcriptional regulation can occur in both ABA dependent manner via ABA-r ...
DOI:: 10.1016/j.plgene.2017.07.003
: https://doi.org/10.1016/j.plgene.2017.07.003

52. Functional characterization of two bZIP transcription factors in Verticillium dahliae

Author:: Yulin Fang; Dianguang Xiong; Longyan Tian; Chen Tang; Yonglin Wang; Chengming Tian
Source:: Gene 2017 v.626 pp. 386-394
ISSN:: 0378-1119
Subject:: Verticillium dahliae; basic-leucine zipper transcription factors; conidia; conidiation; fungi; gene expression regulation; genes; hydrogen peroxide; laccase; mutants; oxidative stress; peroxidase; phenotype; sclerotia; stress response; virulence
Abstract:: ... bZIP transcription factors play various biological roles in stress responses, conidiation, and pathogenicity in pathogenic fungi. Here, we report two bZIP transcription factors (VDAG_08640 and VDAG_08676) of Verticillium dahliae, which were differentially expressed during microsclerotia development and induced by hydrogen peroxide as well. We find that deletion of either gene does not affect micro ...
DOI:: 10.1016/j.gene.2017.05.061
: https://doi.org/10.1016/j.gene.2017.05.061

53. Genome-wide identification and analysis of the basic leucine zipper (bZIP) transcription factor gene family in Ustilaginoidea virens

Author:: Weixiao Yin; Peng Cui; Wei Wei; Yang Lin; Chaoxi Luo
Source:: Genome 2017 v.60 no.12 pp. 1051-1059
ISSN:: 1480-3321
Subject:: Ustilaginoidea virens; basic-leucine zipper transcription factors; bioinformatics; biotic stress; eukaryotic cells; false smut; fungi; gene expression regulation; genes; hydrogen peroxide; leucine zipper; pathogenicity; pathogens; phylogeny; rice; sequence analysis; stress tolerance; transcription (genetics)
Abstract:: ... The basic leucine zipper (bZIP) transcription factor (TF) family is one of the largest and most diverse TF families widely distributed across the eukaryotes. The bZIP TF family plays an important role in growth, development, and response to abiotic or biotic stresses, which have been well characterized in plants, but not in plant pathogenic fungi. In this study, we performed genome-wide and system ...
DOI:: 10.1139/gen-2017-0089
: https://doi.org/10.1139/gen-2017-0089

54. Mutations and interactions in human ERα and bZIP proteins: An in silico approach for cell signaling in breast oncology

Author:: Arundhati Banerjee; Sujay Ray
Source:: Gene 2017 v.610 pp. 90-102
ISSN:: 0378-1119
Subject:: basic-leucine zipper transcription factors; breast neoplasms; breasts; energy; humans; metastasis; molecular dynamics; neoplasm cells; patients; point mutation; protein-protein interactions; signal transduction; solvents
Abstract:: ... Metastasis of breast cancer serves the most aggravating cause for transience in breast cancer patients. Accumulating evidences suggest that signal transduction in human breast cancers commences in estrogen-reliant pattern via signaling of the estrogen-receptor α-subunit (ERα) and XBP-1 (bZIP-domain) proteins. Furthermore, earlier investigations from SAGE and GST pull-down assay, also state that a ...
DOI:: 10.1016/j.gene.2017.01.012
: https://doi.org/10.1016/j.gene.2017.01.012

55. NRF2 overexpression in mesenchymal stem cells induces stem-cell marker expression and enhances osteoblastic differentiation

Author:: Zenan Yuan; Jian Zhang; Yong Huang; Yingcai Zhang; Wei Liu; Genshu Wang; Qi Zhang; Guoying Wang; Yang Yang; Hua Li; Guihua Chen
Source:: Biochemical and biophysical research communications 2017 pp. -
ISSN:: 0006-291X
Subject:: apoptosis; basic-leucine zipper transcription factors; bone formation; cell culture; chlorides; cobalt; databases; hypoxia; oxidative stress; oxygen; stem cells
Abstract:: ... Hypoxic environment has been suggested in stem cell culturing as their physiologic niche requires oxygen tension to maintain stemness. The administration of cobalt chloride (CoCl2) was widely applied in mimicking hypoxia for its economic advantages and convenience. We confirmed that CoCl2 could maintain stemness and promote the osteogenesis capacity of MSCs. However, CoCl2 could induce the apoptos ...
DOI:: 10.1016/j.bbrc.2017.07.083
: https://doi.org/10.1016/j.bbrc.2017.07.083

56. Post‐translational control of ABA signalling: the roles of protein phosphorylation and ubiquitination

Author:: Wenqi Yang; Wei Zhang; Xiaoxue Wang
Source:: Plant biotechnology journal 2017 v.15 no.1 pp. 4-14
ISSN:: 1467-7644
Subject:: abscisic acid; basic-leucine zipper transcription factors; dephosphorylation; embryogenesis; gene expression; germination; ion channels; plant establishment; protein kinases; protein phosphorylation; receptors; signal transduction; stomatal movement; transcription (genetics); ubiquitination
Abstract:: ... The plant phytohormone abscisic acid (ABA) plays significant roles in integrating environmental signals with embryogenesis, germination, seedling establishment, the floral transition and the adaptation of plants to stressful environments by modulating stomatal movement and stress‐responsive gene expression. ABA signalling consists of ABA perception, signal transduction and ABA‐induced responses. A ...
DOI:: 10.1111/pbi.12652
PubMed:: 27767245
PubMed Central:: PMC5253474
: https://doi.org/10.1111/pbi.12652

57. Seed maturation associated transcriptional programs and regulatory networks underlying genotypic difference in seed dormancy and size/weight in wheat (Triticum aestivum L.)

Author:: Yuji Yamasaki; Feng Gao; Mark C. Jordan; Belay T. Ayele
Source:: BMC plant biology 2017 v.17 no.1 pp. 154
ISSN:: 1471-2229
Subject:: seed yield; seed dormancy; transcriptomics; phenotype; basic-leucine zipper transcription factors; seed maturation; wheat; transcription (genetics); gene expression; endosperm; Triticum aestivum; genotype; phenotypic variation; gibberellins; abscisic acid; multigene family; apoptosis; gene regulatory networks
Abstract:: ... BACKGROUND: Maturation forms one of the critical seed developmental phases and it is characterized mainly by programmed cell death, dormancy and desiccation, however, the transcriptional programs and regulatory networks underlying acquisition of dormancy and deposition of storage reserves during the maturation phase of seed development are poorly understood in wheat. The present study performed co ...
DOI:: 10.1186/s12870-017-1104-5
PubMed:: 28915785
PubMed Central:: PMC5603048
: https://doi.org/10.1186/s12870-017-1104-5

58. The role of ZIP transporters and group F bZIP transcription factors in the Zn‐deficiency response of wheat (Triticum aestivum)

Author:: Nicholas P. Evens; Peter Buchner; Lorraine E. Williams; Malcolm J. Hawkesford
Source:: plant journal 2017 v.92 no.2 pp. 291-304
ISSN:: 0960-7412
Subject:: Arabidopsis; Triticum aestivum; basic-leucine zipper transcription factors; binding sites; genes; grain crops; hexaploidy; homeostasis; mutants; nutrient deficiencies; promoter regions; soil; transcription (genetics); transporters; wheat; yeasts; zinc
Abstract:: ... Understanding the molecular basis of zinc (Zn) uptake and transport in staple cereal crops is critical for improving both Zn content and tolerance to low‐Zn soils. This study demonstrates the importance of group F bZIP transcription factors and ZIP transporters in responses to Zn deficiency in wheat (Triticum aestivum). Seven group F TabZIP genes and 14 ZIPs with homeologs were identified in hexap ...
DOI:: 10.1111/tpj.13655
PubMed:: 28771859
PubMed Central:: PMC5656842
: https://doi.org/10.1111/tpj.13655

59. Computational Competitive and Negative Design To Derive a Specific cJun Antagonist

Author:: Alexander Lathbridge; Jody M. Mason
Source:: Biochemistry 2018 v.57 no.42 pp. 6108-6118
ISSN:: 1520-4995
Subject:: antagonists; apoptosis; basic-leucine zipper transcription factors; cell differentiation; cell growth; leucine zipper; neoplasms; osteoporosis; peptide libraries; psoriasis; screening; transcription (genetics)
Abstract:: ... Basic leucine zipper (bZIP) proteins reside at the end of cell-signaling cascades and function to modulate transcription of specific gene targets. bZIPs are recognized as important regulators of cellular processes such as cell growth, apoptosis, and cell differentiation. One such validated transcriptional regulator, activator protein-1, is typically comprised of heterodimers of Jun and Fos family ...
DOI:: 10.1021/acs.biochem.8b00782
: https://doi.org/10.1021/acs.biochem.8b00782

60. Copper excess reduces nitrate uptake by Arabidopsis roots with specific effects on gene expression

Author:: Franz W.R. Hippler; Dirceu Mattos-Jr; Rodrigo M. Boaretto; Lorraine E. Williams
Source:: Journal of plant physiology 2018 v.228 pp. 158-165
ISSN:: 0176-1617
Subject:: Arabidopsis; absorption; basic-leucine zipper transcription factors; copper; gene expression; gene expression regulation; genes; hydroponics; nitrate reductase; nitrates; plasma membrane; proton pump; roots; toxicity
Abstract:: ... Nitrate uptake by plants is mediated by specific transport proteins in roots (NRTs), which are also dependent on the activity of proton pumps that energize the reaction. Nitrogen (N) metabolism in plants is sensitive to copper (Cu) toxicity conditions. To understand how Cu affects the uptake and assimilation processes, this study assesses the inhibitory effects of elevated Cu levels on the express ...
DOI:: 10.1016/j.jplph.2018.06.005
PubMed:: 29933138
PubMed Central:: PMC6090090
: https://doi.org/10.1016/j.jplph.2018.06.005

61. Expression of the Arabidopsis ABF4 gene in potato increases tuber yield, improves tuber quality and enhances salt and drought tolerance

Author:: María Noelia Muñiz García; Juan Ignacio Cortelezzi; Marina Fumagalli; Daniela A. Capiati
Source:: Plant molecular biology 2018 v.98 no.1-2 pp. 137-152
ISSN:: 0167-4412
Subject:: Arabidopsis; Solanum tuberosum; abscisic acid; basic-leucine zipper transcription factors; breeding; crop yield; drought; drought tolerance; environmental factors; food crops; gene expression; genes; market value; new variety; potatoes; processing quality; salinity; salt stress; salt tolerance; soil; transgenic plants; tuber sprouting; tubers; water stress
Abstract:: ... KEY MESSAGE: In this study we show that expression of the Arabidopsis ABF4 gene in potato increases tuber yield under normal and abiotic stress conditions, improves storage capability and processing quality of the tubers, and enhances salt and drought tolerance. Potato is the third most important food crop in the world. Potato plants are susceptible to salinity and drought, which negatively affect ...
DOI:: 10.1007/s11103-018-0769-y
: https://doi.org/10.1007/s11103-018-0769-y

62. The FT/FD‐dependent initiation of flowering under long‐day conditions in the day‐neutral species Nicotiana tabacum originates from the facultative short‐day ancestor Nicotiana tomentosiformis

Author:: Farina A. Beinecke; Lena Grundmann; David R. Wiedmann; Florentin J. Schmidt; Andrea S. Caesar; Marius Zimmermann; Michael Lahme; Richard M. Twyman; Dirk Prüfer; Gundula A. Noll
Source:: plant journal 2018 v.96 no.2 pp. 329-342
ISSN:: 0960-7412
Subject:: Nicotiana sylvestris; Nicotiana tabacum; Nicotiana tomentosiformis; ancestry; basic-leucine zipper transcription factors; flowering; fluorescence; genes; loci; photoperiod; regulatory proteins; tobacco
Abstract:: ... Photoperiod is an important external stimulus governing the precise timing of the floral transition in plants. Members of the FLOWERING LOCUS T (FT)‐like clade of phosphatidylethanolamine‐binding proteins induce this developmental process in numerous species by forming regulatory protein complexes with FD‐like bZIP transcription factors. We identified several thus far unknown FT‐like and FD‐like g ...
DOI:: 10.1111/tpj.14033
: https://doi.org/10.1111/tpj.14033

63. Genome-wide (ChIP-seq) identification of target genes regulated by BdbZIP10 during paraquat-induced oxidative stress

Author:: Ruth C. Martin; Kelly Vining; James E. Dombrowski
Source:: BMC plant biology 2018 v.18 no.1 pp. 58
ISSN:: 1471-2229
Subject:: Arabidopsis; Brachypodium; basic-leucine zipper transcription factors; cations; chromatin; gene ontology; genes; growth and development; high-throughput nucleotide sequencing; homeostasis; moieties; nucleosides; nutrient deficiencies; oxidative stress; paraquat; phosphotransferases (kinases); plant response; precipitin tests; stress tolerance; transporters; viability; zinc
Abstract:: ... BACKGROUND: bZIP transcription factors play a significant role in many aspects of plant growth and development and also play critical regulatory roles during plant responses to various stresses. Overexpression of the Brachypodium bZIP10 (Bradi1g30140) transcription factor conferred enhanced oxidative stress tolerance and increased viability when plants or cells were exposed to the herbicide paraqu ...
DOI:: 10.1186/s12870-018-1275-8
PubMed:: 29636001
PubMed Central:: PMC5894230
: https://doi.org/10.1186/s12870-018-1275-8

64. Genome-wide systematic characterization and its regulatory expression reprogramming process of the bZIP transcription factors during trauma response in Camellia sinensis

Author:: Yajie Xue; Zaibao Zhang; Lei Wang; Yajun Yu; Jinbin Xiao; Jiajia Hou; Shuaibin Lian; Hongyu Yuan; Lin Cheng
Source:: Canadian journal of forest research 2018 v.48 no.11 pp. 1279-1291
ISSN:: 1208-6037
Subject:: Arabidopsis; Camellia sinensis; basic-leucine zipper transcription factors; dimerization; genes; genomics; leucine zipper; models; phylogeny; tea; transcription (genetics); transcriptomics; trees
Abstract:: ... Basic leucine zipper (bZIP) transcription factor (TF) genes regulate numerous biological processes, as well as biotic and abiotic responses. Although the genome of the tea tree (Camellia sinensis (L.) Kuntze) has been released, knowledge regarding the bZIP TF family in C. sinensis, e.g., phylogenetic relationship and transcriptional gene expression profiles, remains limited. In this study, we char ...
DOI:: 10.1139/cjfr-2018-0135
: https://doi.org/10.1139/cjfr-2018-0135

65. Identification and characterization of finger millet OPAQUE2 transcription factor gene under different nitrogen inputs for understanding their role during accumulation of prolamin seed storage protein

Author:: Vikram Singh Gaur; Lallan Kumar; Supriya Gupta; J. P. Jaiswal; Dinesh Pandey; Anil Kumar
Source:: 3 Biotech 2018 v.8 no.3 pp. 163
ISSN:: 2190-572X
Subject:: Eleusine coracana; amino acids; barley; basic-leucine zipper transcription factors; complementary DNA; gene expression; genes; genotype; grain protein; leaves; messenger RNA; nitrogen; open reading frames; phylogeny; prolamins; protein content; rapid amplification of cDNA ends; regulatory sequences; seed development; sequence homology; transcriptome
Abstract:: ... In this study, we report the isolation and characterization of the mRNA encoding OPAQUE2 (O2) like TF of finger millet (FM) (Eleusine coracana) (EcO2). Full-length EcO2 mRNA was isolated using conserved primers designed by aligning O2 mRNAs of different cereals followed by 3′ and 5′ RACE (Rapid Amplification of cDNA Ends). The assembled full-length EcO2 mRNA was found to contain an ORF of 1248-nt ...
DOI:: 10.1007/s13205-018-1150-1
PubMed:: 29527450
PubMed Central:: PMC5840081
: https://doi.org/10.1007/s13205-018-1150-1

66. Overexpression of a wheat (Triticum aestivum L.) bZIP transcription factor gene, TabZIP6, decreased the freezing tolerance of transgenic Arabidopsis seedlings by down-regulating the expression of CBFs

Author:: Wangting Cai; Yaling Yang; Weiwei Wang; Guangyan Guo; Wei Liu; Caili Bi
Source:: Plant physiology and biochemistry 2018 v.124 pp. 100-111
ISSN:: 0981-9428
Subject:: Arabidopsis; Triticum aestivum; basic-leucine zipper transcription factors; cold shock response; cold stress; cold tolerance; cold treatment; freezing; genes; leucine zipper; microarray technology; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; seedlings; transcriptional activation; transgenic plants; two hybrid system techniques; wheat; yeasts
Abstract:: ... The basic leucine zipper (bZIP) proteins play important roles against abiotic stress in plants, including cold stress. However, most bZIPs involved in plant freezing tolerance are positive regulators. Only a few bZIPs function negatively in cold stress response. In this study, TabZIP6, a Group C bZIP transcription factor gene from common wheat (Triticum aestivum L.), was cloned and characterized. ...
DOI:: 10.1016/j.plaphy.2018.01.008
: https://doi.org/10.1016/j.plaphy.2018.01.008

67. Possible inhibition of Arabidopsis VIP1-mediated mechanosensory signaling by streptomycin

Author:: Daisuke Tsugama; Shenkui Liu; Kaien Fujino; Tetsuo Takano
Source:: Plant signaling & behavior 2018 v.13 no.10 pp. e1521236
ISSN:: 1559-2324
Subject:: Arabidopsis thaliana; basic-leucine zipper transcription factors; calcium channels; calcium signaling; cytoplasm; mechanical stress; streptomycin; stress response; tropisms
Abstract:: ... VIP1 (VIRE2-INTERACTING PROTEIN 1) and its close homologues are Arabidopsis thaliana bZIP proteins regulating stress responses and root tropisms. They are present in the cytoplasm under steady conditions, but transiently accumulate in the nucleus when cells are exposed to mechanical stress such as hypo-osmotic stress and touch. This pattern of changes in subcellular localization is unique to VIP1 ...
DOI:: 10.1080/15592324.2018.1521236
PubMed:: 30235047
PubMed Central:: PMC6204804
: https://doi.org/10.1080/15592324.2018.1521236

68. Potential in vitro and ex vivo targeting of bZIP53 involved in stress response and seed maturation in Arabidopsis thaliana by five designed peptide inhibitors

Author:: Prateek Jain; Koushik Shah; Vikas Rishi
Source:: Biochimica et biophysica acta 2018 v.1866 no.12 pp. 1249-1259
ISSN:: 1570-9639
Subject:: Arabidopsis thaliana; DNA; basic-leucine zipper transcription factors; circular dichroism spectroscopy; dimerization; dose response; gel electrophoresis; gene expression; inhibitory concentration 50; leucine zipper; protein-protein interactions; seed maturation; stress response; transfection
Abstract:: ... Basic leucine zipper (bZIP) transcription factors (TFs) are eukaryote-specific proteins that bind to DNA as a homodimer or heterodimer and regulate gene expression. They are involved in several biological processes in plants; therefore inhibiting bZIP-DNA binding activity by targeting protein-protein interface is an attractive proposition with aspects of both basic and applied biology. Here, we de ...
DOI:: 10.1016/j.bbapap.2018.09.007
: https://doi.org/10.1016/j.bbapap.2018.09.007

69. Salt and drought stress and ABA responses related to bZIP genes from V. radiata and V. angularis

Author:: Lanfen Wang; Jifeng Zhu; Xiaoming Li; Shumin Wang; Jing Wu
Source:: Gene 2018 v.651 pp. 152-160
ISSN:: 0378-1119
Subject:: Vigna angularis; Vigna radiata; abscisic acid; basic-leucine zipper transcription factors; chromosomes; crop production; drought; gene expression; genes; leucine zipper; mung beans; phylogeny; promoter regions; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; salt stress; warm season; water stress
Abstract:: ... Mung bean and adzuki bean are warm-season legumes widely cultivated in China. However, bean production in major producing regions is limited by biotic and abiotic stress, such as drought and salt stress. Basic leucine zipper (bZIP) genes play key roles in responses to various biotic and abiotic stresses. However, only several bZIP genes involved in drought and salt stress in legumes, especially Vi ...
DOI:: 10.1016/j.gene.2018.02.005
: https://doi.org/10.1016/j.gene.2018.02.005

70. Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2

Author:: Miao Liu; Hanying Xu; Ling Zhang; Cai Zhang; Liancheng Yang; Enlong Ma; Lianqing Liu; Yanchun Li
Source:: Biochemical and biophysical research communications 2018 v.495 no.1 pp. 325-331
ISSN:: 0006-291X
Subject:: Salvia miltiorrhiza; Western blotting; antioxidant activity; basic-leucine zipper transcription factors; bioactive compounds; fibrosis; glutathione; immunohistochemistry; lungs; malondialdehyde; messenger RNA; oxidative stress; pathogenesis; polymerase chain reaction; protective effect; rats; salvianolic acid; transforming growth factor beta 1
Abstract:: ... Salvianolic acid B (SalB) is one of the most bioactive components extracted from Salvia miltiorrhiza, and its antioxidant capacity corresponds with its protective effects against cell injury from oxidative stress. The aim of the present study was to evaluate the effect of SalB on experimental pulmonary fibrosis and its ability to ameliorate the oxidative/antioxidative imbalance during fibrosis pat ...
DOI:: 10.1016/j.bbrc.2017.11.014
: https://doi.org/10.1016/j.bbrc.2017.11.014

71. Targeting Nrf-2 is a promising intervention approach for the prevention of ethanol-induced liver disease

Author:: Ning Zhao; Fang-Fang Guo; Ke-Qin Xie; Tao Zeng
Source:: Cellular and molecular life sciences 2018 v.75 no.17 pp. 3143-3157
ISSN:: 1420-682X
Subject:: antioxidants; basic-leucine zipper transcription factors; genetic engineering; glutamate-cysteine ligase; glutathione; heme oxygenase (biliverdin-producing); liver diseases; oxidative stress; pathogenesis; therapeutics
Abstract:: ... Alcoholic liver disease (ALD) remains to be a worldwide health problem. It is generally accepted that oxidative stress plays critical roles in the pathogenesis of ALD, and antioxidant therapy represents a logical strategy for the prevention and treatment of ALD. Nuclear factor erythroid-derived 2-like 2 (NFE2L2 or Nrf-2) is essential for the antioxidant responsive element (ARE)-mediated induction ...
DOI:: 10.1007/s00018-018-2852-6
: https://doi.org/10.1007/s00018-018-2852-6

72. The natural compound 2,3,5,4′‐tetrahydroxystilbene‐2‐O‐β‐d glucoside protects against adriamycin‐induced nephropathy through activating the Nrf2‐Keap1 antioxidant pathway

Author:: En‐Yuan Lin; Uyanga Bayarsengee; Ching‐Chiung Wang; Yung‐Hsiao Chiang; Chao‐Wen Cheng
Source:: Environmental toxicology 2018 v.33 no.1 pp. 72-82
ISSN:: 1520-4081
Subject:: urine; lipid peroxidation; glucosides; hypercholesterolemia; albuminuria; protective effect; heme oxygenase (biliverdin-producing); gene expression; oxidation; lactate dehydrogenase; Reynoutria multiflora; NAD (coenzyme); cytotoxicity; mice; kidneys; kidney diseases; diabetes; thiols; antioxidants; doxorubicin; quantitative polymerase chain reaction; intravenous injection; basic-leucine zipper transcription factors; animal models; active ingredients
Abstract:: ... 2,3,5,4′‐Tetrahydroxystilbene‐2‐O‐β‐d‐glucoside (THSG) is an active compound extracted from Polygonum multiflorum Thunb. This herb and radix Polygoni Multiflori preparata have been used to treat arteriosclerosis, hyperlipidemia, hypercholesterolemia, and diabetes for thousands of years. This study aimed to investigate the protective effects of THSG in an Adriamycin (AD)‐induced focal segmental glo ...
DOI:: 10.1002/tox.22496
: https://doi.org/10.1002/tox.22496

73. CabZIP53 is targeted by CaWRKY40 and act as positive regulator in pepper defense against Ralstonia solanacearum and thermotolerance

Author:: Ali Noman; Ansar Hussain; Muhammad Furqan Ashraf; Muhammad Ifnan Khan; Zhiqin Liu; Shuilin He
Source:: Environmental and experimental botany 2019 v.159 pp. 138-148
ISSN:: 0098-8472
Subject:: Agrobacterium; Capsicum annuum; Ralstonia solanacearum; basic-leucine zipper transcription factors; biotic stress; cell death; gene overexpression; gene regulatory networks; gene silencing; genetic markers; heat tolerance; hydrogen peroxide; hypersensitive response; leaves; pathogens; pepper; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; transcription (genetics)
Abstract:: ... Broad range transcriptional changes after pathogen invasion decide immune responses to these invaders. The responses of Capsicum annuum plants to bacterial pathogen Ralstonia solanacearum and high-temperature-high-humidity (HTHH) conditions are coordinated by different transcription factors. However, the basic molecular mechanism is not clear. The functions of different Capsicum annuum bZIP transc ...
DOI:: 10.1016/j.envexpbot.2018.12.017
: https://doi.org/10.1016/j.envexpbot.2018.12.017

74. Comparative identification, characterization, and expression analysis of bZIP gene family members in watermelon and melon genomes

Author:: Necdet Mehmet Unel; Fadime Cetin; Yasin Karaca; Yasemin Celik Altunoglu; Mehmet Cengiz Baloglu
Source:: Plant growth regulation 2019 v.87 no.2 pp. 227-243
ISSN:: 0167-6903
Subject:: basic-leucine zipper transcription factors; chromosomes; databases; genes; genetic analysis; leaves; leucine zipper; phylogeny; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; sequence analysis; tissues; water stress; watermelons
Abstract:: ... The family of basic leucine zipper (bZIP) transcription factors plays diverse crucial roles in numerous biological processes. Despite the identification of bZIP genes in several plants, to our knowledge, bZIP members in watermelon and melon are yet to be comprehensively investigated. The genomes of watermelon and melon encode 59 ClabZIP and 75 CmbZIP putative genes, respectively. Both bZIP protein ...
DOI:: 10.1007/s10725-018-0465-6
: https://doi.org/10.1007/s10725-018-0465-6

75. Egcg maintained nrf2-mediated redox homeostasis and minimized etoposide resistance in lung cancer cells

Author:: Suchisnigdha Datta; Dona Sinha
Source:: Journal of functional foods 2019 pp. -
ISSN:: 1756-4646
Subject:: adenocarcinoma; basic-leucine zipper transcription factors; cell lines; drug therapy; epigallocatechin gallate; etoposide; homeostasis; lung neoplasms; lungs; multiple drug resistance; neoplasm cells
Abstract:: ... Lung adenocarcinomas exhibit chemoresistance mostly due to deregulation of nuclear factor erythroid-derived 2-like 2 (Nrf2). Epigallocatechin gallate (EGCG), was investigated for altering Nrf2 mediated etoposide resistance in different lung adenocarcinoma cells. In A549, EGCG downregulated nuclear Nrf2 by upregulating the nuclear localization of Keap1 whereas in NCIH23, EGCG augmented Nrf2 by redu ...
DOI:: 10.1016/j.jff.2019.103553
: https://doi.org/10.1016/j.jff.2019.103553

76. Genome-wide identification, structural and gene expression analysis of the bZIP transcription factor family in sweet potato wild relative Ipomoea trifida

Author:: Zhengmei Yang; Jian Sun; Yao Chen; Panpan Zhu; Lei Zhang; Shaoyuan Wu; Daifu Ma; Qinghe Cao; Zongyun Li; Tao Xu
Source:: BMC genetics 2019 v.20 no.1 pp. 41
ISSN:: 1471-2156
Subject:: Arabidopsis thaliana; DNA shuffling; Ipomoea; Solanum lycopersicum; abiotic stress; basic-leucine zipper transcription factors; chromosomes; exons; gene amplification; gene expression; growth and development; introns; leucine zipper; phylogeny; prediction; promoter regions; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; stress response; sweet potatoes; transcriptome; wild relatives
Abstract:: ... BACKGROUND: The basic leucine zipper (bZIP) transcription factor is one of the most abundant and conserved transcription factor families. In addition to being involved in growth and development, bZIP transcription factors also play an important role in plant adaption to abiotic stresses. RESULTS: A total of 41 bZIP genes that encode 66 proteins were identified in Ipomoea trifida. They were distrib ...
DOI:: 10.1186/s12863-019-0743-y
PubMed:: 31023242
PubMed Central:: PMC6482516
: https://doi.org/10.1186/s12863-019-0743-y

77. Overexpression of Vitis vinifera VvbZIP60 enhances Arabidopsis resistance to powdery mildew via the salicylic acid signaling pathway

Author:: Yi-He Yu; Ze-Ling Jiao; Lu Bian; Yu-Tong Wan; Ke-Ke Yu; Guo-Hai Zhang; Da-Long Guo
Source:: Scientia horticulturae 2019 v.256 pp. 108640
ISSN:: 0304-4238
Subject:: 4',6-diamidino-2-phenylindole; Arabidopsis; Vitis vinifera; amino acid sequences; basic-leucine zipper transcription factors; breeding; crop production; disease resistance; gene expression; genes; grapes; green fluorescent protein; jasmonic acid; leaves; messenger RNA; methyl jasmonate; pathogenesis; pathogens; phylogeny; powdery mildew; salicylic acid; sequence alignment; signal transduction; systemic acquired resistance; tissues; transcriptional activation; transgenic plants; viticulture; yeasts
Abstract:: ... Powdery mildew is a fungus that causes major losses in grape production worldwide. Recent studies demonstrate bZIP transcription factors (TFs) play an important role in plant defense against fungal pathogens. To investigate whether one or more bZIP TFs is involved in the common grapevine’s defense against powdery mildew, which could provide candidate genes for breeding powdery mildew-resistant gra ...
DOI:: 10.1016/j.scienta.2019.108640
: https://doi.org/10.1016/j.scienta.2019.108640

78. Regulation of Ov2 by virus encoded microRNAs

Author:: Katie Nightingale; Inga Dry; John Hopkins; Robert Dalziel
Source:: Veterinary research communications 2019 v.43 no.2 pp. 99-104
ISSN:: 0165-7380
Subject:: Herpesviridae; Western blotting; basic-leucine zipper transcription factors; binding sites; flow cytometry; genes; malignant catarrhal fever; microRNA; mutation; protein synthesis; virus replication; viruses
Abstract:: ... Herpesviruses encode miRNAs that target both virus and host genes; however their role in herpesvirus biology is still poorly understood. We previously identified thirty five miRNAs encoded by OvHV-2; the causative agent of malignant catarrhal fever (MCF) and are investigating the role of these miRNAs in regulating expression of OvHV-2 genes that play important roles in virus biology. Analysis, usi ...
DOI:: 10.1007/s11259-019-09749-9
PubMed:: 30888610
PubMed Central:: PMC6525144
: https://doi.org/10.1007/s11259-019-09749-9

79. Review: ABA, flavonols, and the evolvability of land plants

Author:: Cecilia Brunetti; Federico Sebastiani; Massimiliano Tattini
Source:: Plant science 2019 v.280 pp. 448-454
ISSN:: 0168-9452
Subject:: Bryophyta; abscisic acid; basic-leucine zipper transcription factors; biosynthesis; dormancy; embryophytes; evolution; quercetin; second messengers; seeds; stomatal movement
Abstract:: ... There is evidence that the ABA signaling pathway has greatly contributed to increase the complexity of land plants, thereby sustaining their ability to adapt in an ever-changing environment. The regulatory functions of the ABA signaling pathway go well beyond the movements of stomata and the dormancy of seeds. For instance, the ABA signaling regulates the flavonoid biosynthesis, consistent with th ...
DOI:: 10.1016/j.plantsci.2018.12.010
: https://doi.org/10.1016/j.plantsci.2018.12.010

80. Roles of pepper bZIP transcription factor CaATBZ1 and its interacting partner RING‐type E3 ligase CaASRF1 in modulation of ABA signalling and drought tolerance

Author:: Hyunhee Joo; Chae Woo Lim; Sung Chul Lee
Source:: plant journal 2019 v.100 no.2 pp. 399-410
ISSN:: 0960-7412
Subject:: Arabidopsis; Capsicum annuum; RING finger domains; abscisic acid; basic-leucine zipper transcription factors; drought tolerance; gain-of-function mutation; gene overexpression; gene silencing; loss-of-function mutation; pepper; phenotype; screening; stress response; transgenic plants; two hybrid system techniques; ubiquitin-protein ligase; ubiquitination; water stress
Abstract:: ... Ubiquitination is a eukaryotic protein modulation system for identifying and affecting proteins that are no longer needed in the cell. In a previous study, we elucidated the biological function of CaASRF1, which contains a RING finger domain and functions as an E3 ligase. We showed that CaASRF1 positively modulates abscisic acid (ABA) signalling and drought stress tolerance by modulating the stabi ...
DOI:: 10.1111/tpj.14451
: https://doi.org/10.1111/tpj.14451

81. Tartary buckwheat transcription factor FtbZIP83 improves the drought/salt tolerance of Arabidopsis via an ABA-mediated pathway

Author:: Qi Li; Qi Wu; Anhu Wang; Bingbing Lv; Qixin Dong; Yingjun Yao; Qiong Wu; Haixia Zhao; Chenglei Li; Hui Chen; XiaoLi Wang
Source:: Plant physiology and biochemistry 2019 v.144 pp. 312-323
ISSN:: 0981-9428
Subject:: Arabidopsis; Fagopyrum tataricum; abscisic acid; antioxidant enzymes; basic-leucine zipper transcription factors; buckwheat; drought; enzyme activity; gene expression regulation; gene overexpression; genes; malondialdehyde; messenger RNA; polyethylene glycol; proline; promoter regions; reactive oxygen species; salt stress; salt tolerance; sequence analysis; signal transduction; sodium chloride; stress response; transgenic plants; water stress
Abstract:: ... Plants are subjected to a variety of abiotic stresses during their lifetime, and drought and salt stress are some of the main causes of reduced crop yields. Previous studies have shown that AREB/ABFs within bZIP transcription factors are involved in plant drought and salt stress responses in an ABA-dependent manner. However, the properties and functions of AREB/ABFs in Fagopyrum tataricum, a cerea ...
DOI:: 10.1016/j.plaphy.2019.10.003
: https://doi.org/10.1016/j.plaphy.2019.10.003

82. A stress-responsive bZIP transcription factor OsbZIP62 improves drought and oxidative tolerance in rice

Author:: Shiqin Yang; Kai Xu; Shoujun Chen; Tianfei Li; Hui Xia; Liang Chen; Hongyan Liu; Lijun Luo
Source:: BMC plant biology 2019 v.19 no.1 pp. 260
ISSN:: 1471-2229
Subject:: Oryza sativa; abscisic acid; amino acids; basic-leucine zipper transcription factors; crop yield; crops; drought; drought tolerance; gene overexpression; genes; genetic engineering; hydrogen peroxide; leucine zipper; mitogen-activated protein kinase; mutants; oxidative stress; phenotype; rice; sequence analysis; signal transduction; stress response; stress tolerance; transcriptional activation; transcriptomics; transgenic plants; water stress
Abstract:: ... BACKGROUND: Drought is a major abiotic stress factor that influences the yield of crops. Basic leucine zipper motif (bZIP) transcription factors play an important regulatory role in plant drought stress responses. However, the functions of a number of bZIP transcription factors in rice are still unknown. RESULTS: In this study, a novel drought stress-related bZIP transcription factor, OsbZIP62, wa ...
DOI:: 10.1186/s12870-019-1872-1
PubMed:: 31208338
PubMed Central:: PMC6580479
: https://doi.org/10.1186/s12870-019-1872-1

83. ABA-dependent bZIP transcription factor, CsbZIP18, from Camellia sinensis negatively regulates freezing tolerance in Arabidopsis

Author:: Lina Yao; Xinyuan Hao; Hongli Cao; Changqing Ding; Yajun Yang; Lu Wang; Xinchao Wang
Source:: Plant cell reports 2020 v.39 no.4 pp. 553-565
ISSN:: 0721-7714
Subject:: Arabidopsis; Camellia sinensis; abscisic acid; acclimation; basic-leucine zipper transcription factors; cold; cold stress; cold tolerance; cultivars; electrolyte leakage; freezing; gene overexpression; genes; homeostasis; leucine zipper; photosystem II; signal transduction; stress response; tea
Abstract:: ... KEY MESSAGE: Overexpression of the tea plant gene CsbZIP18 in Arabidopsis impaired freezing tolerance, and CsbZIP18 is a negative regulator of ABA signaling and cold stress. Basic region/leucine zipper (bZIP) transcription factors play important roles in the abscisic acid (ABA) signaling pathway and abiotic stress response in plants. However, few bZIP transcription factors have been functionally c ...
DOI:: 10.1007/s00299-020-02512-4
: https://doi.org/10.1007/s00299-020-02512-4

84. Asparagus racemosus bZIP transcription factor-regulated squalene epoxidase (ArSQE) promotes germination and abiotic stress tolerance in transgenic tobacco

Author:: Swati Upadhyay; Gajendra Singh Jeena; Sunil Kumar; Rakesh Kumar Shukla
Source:: Plant science 2020 v.290 pp. 110291
ISSN:: 0168-9452
Subject:: Asparagus racemosus; abiotic stress; antifungal agents; basic-leucine zipper transcription factors; biosynthesis; chemistry; complement; ergosterol; genetically modified organisms; germination; information; medicinal properties; mutants; promoter regions; seedlings; squalene monooxygenase; steroid saponins; stress response; stress tolerance; tobacco; yeasts
Abstract:: ... A. racemosus is a rich source of pharmacologically active steroidal saponins. Most of the studies are related to its chemistry and pharmacology, but the pathway involved in the biosynthesis of steroidal saponin is not much emphasized. Squalene epoxidase acts as a rate-limiting enzyme in this biosynthesis. In this study, we have selected root specific squalene epoxidase ArSQE from A. racemosus for ...
DOI:: 10.1016/j.plantsci.2019.110291
: https://doi.org/10.1016/j.plantsci.2019.110291

85. The CmbZIP1 transcription factor of chrysanthemum negatively regulates shoot branching

Author:: Cunquan Yuan; Jingtian Shi; Liangjun Zhao
Source:: Plant physiology and biochemistry 2020 v.151 pp. 69-76
ISSN:: 0981-9428
Subject:: Arabidopsis; Chrysanthemum; auxins; basic-leucine zipper transcription factors; branching; buds; genes; leucine zipper; ornamental plants; shade
Abstract:: ... The basic region/leucine zipper (bZIP) transcription factors play key roles in regulating diverse biological processes in plants. However, their participation in shoot branching has been rarely reported. Here, we isolated a CmbZIP1 transcription factor gene, a member of the bZIP family, from chrysanthemum. Subcellular localization analysis indicated that CmbZIP1 is a nuclear protein. Tissue-specif ...
DOI:: 10.1016/j.plaphy.2020.03.013
: https://doi.org/10.1016/j.plaphy.2020.03.013

86. Dietary walnut as food factor to rescue from NSAID-induced gastrointestinal mucosal damages

Author:: Jeong Min An; Eun Hye Kim; Hookeun Lee; Ho Jae Lee; Ki Baik Hahm
Source:: Archives of biochemistry and biophysics 2020 v.689 pp. 108466
ISSN:: 0003-9861
Subject:: Helicobacter pylori; alcohols; animal models; antioxidant activity; antioxidant enzymes; aspirin; basic-leucine zipper transcription factors; bile; biophysics; carbon monoxide; food intake; gastric acid; glutamate-cysteine ligase; heme oxygenase (biliverdin-producing); iron; quinones; stomach; toxicity; walnuts
Abstract:: ... Nuclear factor erythroid-derived 2-like 2 (Nrf-2) is transcription factor implicated in the antioxidant response element-mediated induction of endogenous antioxidant enzyme such as heme oxygenase-1 (HO-1), glutamate-cysteine ligase, and NAD(P)H quinone dehydrogenase 1, among which HO-1 is an enzyme catalyzing the degradation of heme.producing biliverdin, ferrous iron, and carbon monoxide. In the s ...
DOI:: 10.1016/j.abb.2020.108466
: https://doi.org/10.1016/j.abb.2020.108466

87. Differentially expressed bZIP transcription factors confer multi-tolerances in Gossypium hirsutum L.

Author:: Xiaoge Wang; Xuke Lu; Waqar Afzal Malik; Xiugui Chen; Junjuan Wang; Delong Wang; Shuai Wang; Chao Chen; Lixue Guo; Wuwei Ye
Source:: International journal of biological macromolecules 2020 v.146 pp. 569-578
ISSN:: 0141-8130
Subject:: Arabidopsis; Gossypium hirsutum; abiotic stress; abscisic acid; basic-leucine zipper transcription factors; biotic stress; gene expression regulation; genes; heat; leucine zipper; phylogeny; sequence analysis; signal transduction
Abstract:: ... Basic leucine zipper (bZIP) transcription factor plays an important role in various biological processes, such as response to biotic and abiotic stresses. In this study we performed a systematic investigation and analysis of bZIP gene family in Gossypium hirsutum to predict their functions in response to different abiotic stresses. A total of 207 bZIP genes were identified from Gossypium hirsutum ...
DOI:: 10.1016/j.ijbiomac.2020.01.013
: https://doi.org/10.1016/j.ijbiomac.2020.01.013

88. Genome-Wide Identification and Expression Analysis of the Strawberry FvbZIP Gene Family and the Role of Key Gene FabZIP46 in Fruit Resistance to Gray Mold

Author:: Bei Lu; Yuanhua Wang; Geng Zhang; Yingna Feng; Zhiming Yan; Jianhua Wu; Xuehao Chen
Source:: Plants 2020 v.9 no.9 pp. -
ISSN:: 2223-7747
Subject:: Botrytis cinerea; amino acid sequences; basic-leucine zipper transcription factors; bioinformatics; chromosome mapping; chromosomes; disease resistance; fruit diseases; fruits; gene overexpression; genes; genetically modified organisms; gray mold; strawberries
Abstract:: ... A total of 54 FvbZIP genes were identified from the strawberry genome. These genes were found to be unevenly distributed on seven different chromosomes, and two of the genes had no matching chromosomal localization. FvbZIP genes were divided into 10 subfamilies according to protein sequence, and the structures of these genes were found to be highly conserved. Based on the bioinformatics analysis o ...
DOI:: 10.3390/plants9091199
: https://doi.org/10.3390/plants9091199

89. Polyphenolics in ramontchi protect cardiac tissues via suppressing isoprenaline-induced oxidative stress and inflammatory responses in Long-Evans rats

Author:: Noushin Akter; Faizul Islam Chowdhury; Saima Selim; Shariful Islam Nayan; Ferdous Khan; Nusrat Subhan; Hemayet Hossain; Md Mizanur Rahman; Md. Areeful Haque; Md Ashraful Alam
Source:: Journal of functional foods 2020 v.75 pp. 104250
ISSN:: 1756-4646
Subject:: Flacourtia indica; advanced oxidation protein products; alanine transaminase; animal disease models; anti-inflammatory activity; antioxidant activity; antioxidant enzymes; antioxidant genes; aspartate transaminase; basic-leucine zipper transcription factors; cardiomyocytes; cardioprotective effect; catalase; creatine kinase; enzyme activity; fruits; gene expression; gene expression regulation; glutathione peroxidase; heme oxygenase (biliverdin-producing); inducible nitric oxide synthase; inflammation; interleukin-1; interleukin-6; isoprenaline; malondialdehyde; nitric oxide; oxidative stress; polyphenols; rats; superoxide dismutase; transcription factor NF-kappa B; transforming growth factor beta; tumor necrosis factor-alpha
Abstract:: ... This investigation was aimed to explore the cardioprotective effect of Ramontchi fruits (Flacourtia indica; FI) in isoprenaline-administered Long-Evans rats. Administration of isoprenaline increased the total heart wet weight, MDA, NO, and APOP as well as ALT, AST, and CK-MB levels, which were normalized by FI fruits treatment. Moreover, expressions of antioxidant genes i.e., Nrf-2, HO-1, HO-2, SO ...
DOI:: 10.1016/j.jff.2020.104250
: https://doi.org/10.1016/j.jff.2020.104250

90. SlEAD1, an EAR motif-containing ABA down-regulated novel transcription repressor regulates ABA response in tomato

Author:: Wei Wang; Xutong Wang; Yating Wang; Ganghua Zhou; Chen Wang; Saddam Hussain; Adnan; Rao Lin; Tianya Wang; Shucai Wang
Source:: GM crops & food 2020 v.11 no.4 pp. 275-289
ISSN:: 2164-5701
Subject:: Solanum lycopersicum; abiotic stress; abscisic acid; basic-leucine zipper transcription factors; biosynthesis; gene editing; gene expression; gene expression regulation; genetically modified plants; mutants; plant response; protein kinases; protoplasts; quantitative polymerase chain reaction; receptors; reporter genes; reverse transcriptase polymerase chain reaction; root growth; roots; seed germination; signal transduction; stress tolerance; tomatoes; transcription (genetics)
Abstract:: ... EAR motif-containing proteins are able to repress gene expression, therefore play important roles in regulating plants growth and development, plant response to environmental stimuli, as well as plant hormone signal transduction. ABA is a plant hormone that regulates abiotic stress tolerance in plants via signal transduction. ABA signaling via the PYR1/PYLs/RCARs receptors, the PP2Cs phosphatases, ...
DOI:: 10.1080/21645698.2020.1790287
: https://doi.org/10.1080/21645698.2020.1790287

91. Xanthotoxin and umbelliferone attenuate cognitive dysfunction in a streptozotocin‐induced rat model of sporadic Alzheimer's disease: The role of JAK2/STAT3 and Nrf2/HO‐1 signalling pathway modulation

Author:: Merhan O. Hindam; Rabab H. Sayed; Krystyna Skalicka‐Woźniak; Barbara Budzyńska; Nesrine S. EL Sayed
Source:: Phytotherapy research 2020 v.34 no.9 pp. 2351-2365
ISSN:: 0951-418X
Subject:: Alzheimer disease; animal models; basic-leucine zipper transcription factors; cell death; cognition; cognitive disorders; glutathione; interleukin-6; malondialdehyde; methoxsalen; neurons; neuroprotective effect; oxidative stress; phytotherapy; prostaglandin synthase; protein synthesis; rats; research; signal transduction; streptozotocin; testing; tumor necrosis factor-alpha; umbelliferones; water
Abstract:: ... The aim of the present study was to assess the neuroprotective effects of xanthotoxin and umbelliferone in streptozotocin (STZ)‐induced cognitive dysfunction in rats. Animals were injected intracerebroventricularly (ICV) with STZ (3 mg/kg) once to induce a sporadic Alzheimer's disease (SAD)‐like condition. Xanthotoxin or umbelliferone (15 mg/kg, i.p.) were administered 5 hr after ICV‐STZ and daily ...
DOI:: 10.1002/ptr.6686
: https://doi.org/10.1002/ptr.6686

92. A genome-wide comparative analysis of bZIP transcription factors in G. arboreum and G. raimondii (Diploid ancestors of present-day cotton)

Author:: Farrukh Azeem; Hira Tahir; Usman Ijaz; Tayyaba Shaheen
Source:: Physiology and molecular biology of plants 2020 v.26 no.3 pp. 433-444
ISSN:: 0971-5894
Subject:: Arabidopsis thaliana; Gossypium arboreum; Gossypium raimondii; ancestry; basic-leucine zipper transcription factors; chromosomes; cotton; diploidy; exons; genome-wide association study; introns; leucine zipper; models; phylogeny; plant growth; stress response
Abstract:: ... Basic leucine zipper motif (bZIP) transcription factors (TFs) are involved in plant growth regulation, development, and environmental stress responses. These genes have been well characterized in model plants. In current study, a genome-wide analysis of bZIP genes was performed in Gossypium raimondii and Gossypium arboreum taking Arabidopsis thaliana as a reference genome. In total, 85 members of ...
DOI:: 10.1007/s12298-020-00771-9
PubMed:: 32205921
PubMed Central:: PMC7078431
: https://doi.org/10.1007/s12298-020-00771-9

93. 18β-Glycyrrhetinic acid inhibits IL-1β-induced inflammatory response in mouse chondrocytes and prevents osteoarthritic progression by activating Nrf2

Author:: Boda Chen; Dingchao Zhu; Chenglong Xie; Yifeng Shi; Libin Ni; Huawei Zhang; Sunlong Li; Jiajie Lu; Jian Xiao; Weiyi Xia; Chongan Huang; Xiangyang Wang
Source:: Food & function 2021 v.12 no.18 pp. 8399-8410
ISSN:: 2042-650X
Subject:: Glycyrrhiza glabra; basic-leucine zipper transcription factors; bioactive compounds; cartilage; chondrocytes; collagen; extracellular matrix; histology; inducible nitric oxide synthase; inflammation; interleukin-6; matrix metalloproteinase 13; mice; necrosis; neoplasms; nitric oxide; osteoarthritis; prostaglandin synthase; prostaglandins; sclerosis; synovitis; therapeutics; transcription factor NF-kappa B
Abstract:: ... Osteoarthritis (OA) is presently the most prevalent form of chronic degenerative joint disease, which is characterized by erosion of articular cartilage, subchondral bone sclerosis and synovitis. Accumulating evidence has revealed that 18β-glycyrrhetinic acid (18β-GA), a major bioactive component derived from Glycyrrhiza glabra, exerts anti-inflammatory effects on several diseases. However, the an ...
DOI:: 10.1039/d1fo01379c
: https://doi.org/10.1039/d1fo01379c

94. Adenosine 5′-monophosphate-activated protein kinase ameliorates bovine adipocyte oxidative stress by inducing antioxidant responses and autophagy

Author:: Qiushi Xu; Yunhui Fan; Juan J. Loor; Yusheng Liang; Xudong Sun; Hongdou Jia; Chenxu Zhao; Chuang Xu
Source:: Journal of dairy science 2021 v.104 no.4 pp. 4516-4528
ISSN:: 0022-0302
Subject:: Holstein; adenosine; adipocytes; adipose tissue; antioxidant activity; autophagy; basic-leucine zipper transcription factors; blood serum; catalase; dairy science; genes; glutathione peroxidase; glutathione transferase; heme oxygenase (biliverdin-producing); homeostasis; ketosis; malondialdehyde; oxidative stress; protein kinases; superoxide dismutase
Abstract:: ... Adipose tissue concentration of reactive oxygen species (ROS) increases in dairy cows with ketosis, suggesting that the tissue experiences oxidative stress. Autophagy, an adaptive response to cellular stress, has been shown to promote survival and plays a critical role in antioxidant responses. Dysregulation of adenosine 5′-monophosphate-activated protein kinase (AMPK) is closely related to antiox ...
DOI:: 10.3168/jds.2020-18728
: https://doi.org/10.3168/jds.2020-18728

95. Cardamonin protects nucleus pulposus cells against IL-1β-induced inflammation and catabolism via Nrf2/NF-κB axis

Author:: Chenglong Xie; Haiwei Ma; Yifeng Shi; Junli Li; Hongqiang Wu; Ben Wang; Zhenxuan Shao; Chongan Huang; Jiaoxiang Chen; Liaojun Sun; Yifei Zhou; Naifeng Tian; Yaosen Wu; Weiyang Gao; Aimin Wu; Xiangyang Wang; Xiaolei Zhang
Source:: Food & function 2021 v.12 no.6 pp. 2703-2714
ISSN:: 2042-650X
Subject:: Alpinia hainanensis; anti-inflammatory activity; basic-leucine zipper transcription factors; catabolism; chalcone; collagen; degradation; inducible nitric oxide synthase; inflammation; interleukin-6; intervertebral disks; intragastric administration; matrix metalloproteinase 13; models; nitric oxide; pain; prostaglandin synthase; prostaglandins; protective effect; rats; therapeutics; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:: ... Intervertebral disc degeneration (IVDD) is one of the major causes of low back pain, but effective therapies are still lacking because of its complicated pathology. It has been demonstrated that increased levels of interleukin-1β (IL-1β) may promote the development of IVDD. Cardamonin (CAR) is a chalcone extracted from Alpinia katsumadai and other plants. It exhibits an anti-inflammatory effect in ...
DOI:: 10.1039/d0fo03353g
: https://doi.org/10.1039/d0fo03353g

96. Compatibility with Semen Sojae Praeparatum attenuates hepatotoxicity of Gardeniae Fructus by regulating the microbiota, promoting butyrate production and activating antioxidant response

Author:: Yusha Luo; Xingjie Zhang; Wen Zhang; Qiliang Yang; Wei You; Jun Wen; Tingting Zhou
Source:: Phytomedicine 2021 v.90 pp. 153656
ISSN:: 0944-7113
Subject:: Enterococcus; Lactobacillus; Prevotella; Western blotting; antibiotics; antioxidant activity; basic-leucine zipper transcription factors; butyrates; cecum; colon; dysbiosis; gas chromatography-mass spectrometry; hepatotoxicity; histopathology; immunohistochemistry; intestinal microorganisms; lipopolysaccharides; liver; metabolism; metabolites; permeability; protective effect; China
Abstract:: ... Herb-induced liver injury is a leading cause of drug-induced liver injury in China and its incidence is also increasing worldwide. Gardeniae Fructus (ZZ) has aroused wide concern for hepatotoxicity in recent decades. But when ZZ is administered in combination with Semen Sojae Praeparatum (DDC) to compose a herbal pair Zhizichi Decoction (ZZCD), lower hepatotoxicity is observed. The mechanism invol ...
DOI:: 10.1016/j.phymed.2021.153656
: https://doi.org/10.1016/j.phymed.2021.153656

97. Curcumin Suppresses the Lipid Accumulation and Oxidative Stress Induced by Benzo[a]pyrene Toxicity in HepG2 Cells

Author:: Seung-Cheol Lee; Seung-Cheol Jee; Min Kim; Soee Kim; Min Kyoung Shin; Yunkyung Kim; Jung-Suk Sung
Source:: Antioxidants 2021 v.10 no.8 pp. -
ISSN:: 2076-3921
Subject:: Curcuma longa; DNA damage; antioxidant activity; aryl hydrocarbon receptors; basic-leucine zipper transcription factors; benzo(a)pyrene; bioactive compounds; carcinogens; cell nucleus; cell viability; curcumin; cytochrome P-450; cytotoxicity; hepatotoxicity; human cell lines; lipemic effect; lipids; metabolic detoxification; oxidative stress; polypeptides; protein denaturation; reactive oxygen species; toxicity testing; turmeric
Abstract:: ... Benzo[a]pyrene (B[a]P) is a potentially hepatotoxic group-1 carcinogen taken up by the body through ingestion of daily foods. B[a]P is widely known to cause DNA and protein damages, which are closely related to cell transformation. Accordingly, studies on natural bioactive compounds that attenuate such chemical-induced toxicities have significant impacts on public health. This study aimed to uncov ...
DOI:: 10.3390/antiox10081314
: https://doi.org/10.3390/antiox10081314

98. Ethephon-Induced Ethylene Enhances Starch Degradation and Sucrose Transport with an Interactive Abscisic Acid-Mediated Manner in Mature Leaves of Oilseed rape (Brassica napus L.)

Author:: Bok-Rye Lee; Rashed Zaman; Van Hien La; Dong-Won Bae; Tae-Hwan Kim
Source:: Plants 2021 v.10 no.8 pp. -
ISSN:: 2223-7747
Subject:: 9-cis-epoxycarotenoid dioxygenase; Brassica napus; abscisic acid; alpha-amylase; basic helix-loop-helix transcription factors; basic-leucine zipper transcription factors; beta-amylase; carbohydrate content; carbohydrate metabolism; cell senescence; chlorophyll; cysteine proteinases; ethephon; ethylene; foliar spraying; gene expression; gene expression regulation; leaf chlorophyll content; leaves; phloem; physiological transport; plant exudates; protein-serine-threonine kinases; rapeseed; senescence (aging); starch; sucrose; transporters
Abstract:: ... The leaf senescence process is characterized by the degradation of macromolecules in mature leaves and the remobilization of degradation products via phloem transport. The phytohormone ethylene mediates leaf senescence. This study aimed to investigate the ethephon-induced ethylene effects on starch degradation and sucrose remobilization through their interactive regulation with other hormones. Eth ...
DOI:: 10.3390/plants10081670
: https://doi.org/10.3390/plants10081670

99. Gallic Acid Improves Diabetic Steatosis by Downregulating MicroRNA-34a-5p through Targeting NFE2L2 Expression in High-Fat Diet-Fed db/db Mice

Author:: Ang-Tse Lee; Mon-Yuan Yang; Yi-Ju Lee; Tzu-Wei Yang; Chi-Chih Wang; Chau-Jong Wang
Source:: Antioxidants 2021 v.11 no.1 pp. -
ISSN:: 2076-3921
Subject:: basic-leucine zipper transcription factors; fatty liver; fatty-acid synthase; gallic acid; glucose; high fat diet; lipogenesis; liver; mice; microRNA; microarray technology; noninsulin-dependent diabetes mellitus; oleic acid; palmitic acid; sterols; therapeutics; triacylglycerols
Abstract:: ... Type 2 diabetes mellitus (T2DM) has become epidemic worldwide and is strongly associated with nonalcoholic fatty liver disease (NAFLD). The molecular mechanisms of microRNAs in NAFLD and T2DM development and the corresponding therapies remain unclear. We performed microRNA microarray validation to determine whether hepatic miR-34a-5p was significantly upregulated in db/db mice fed with a high-fat ...
DOI:: 10.3390/antiox11010092
: https://doi.org/10.3390/antiox11010092

100. GmCRY1s modulate gibberellin metabolism to regulate soybean shade avoidance in response to reduced blue light

Author:: Xiangguang Lyu; Qican Cheng; Chao Qin; Yinghui Li; Xinying Xu; Ronghuan Ji; Ruolan Mu; Hongyu Li; Tao Zhao; Jun Liu; Yonggang Zhou; Haiyan Li; Guodong Yang; Qingshan Chen; Bin Liu
Source:: Molecular plant 2021 v.14 no.2 pp. 298-314
ISSN:: 1674-2052
Subject:: CRISPR-Cas systems; basic-leucine zipper transcription factors; biochemical pathways; blue light; cryptochromes; cultivars; density; far-red light; gene expression; gibberellins; intercropping; lodging; metabolism; mutants; planting; red light; shade; soybeans; stem elongation
Abstract:: ... Soybean is an important legume crop that displays the classic shade avoidance syndrome (SAS), including exaggerated stem elongation, which leads to lodging and yield reduction under density farming conditions. Here, we compared the effects of two shade signals, low red light to far-red light ratio (R:FR) and low blue light (LBL), on soybean status and revealed that LBL predominantly induces excess ...
DOI:: 10.1016/j.molp.2020.11.016
: https://doi.org/10.1016/j.molp.2020.11.016

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1. Predicting specificity in bZIP coiled-coil protein interactions

2. DNA bending by bHLH charge variants

3. Cladosporium fulvum CfHNNI1 induces hypersensitive necrosis, defence gene expression and disease resistance in both host and nonhost plants

4. Glucocorticoid-stimulated preadipocyte differentiation is mediated through acetylation of C/EBPβ by GCN5

5. Reconstruction of ancestral protein interaction networks for the bZIP transcription factors

6. Distinct regions of ATF/CREB proteins Atf1 and Pcr1 control recombination hotspot ade6-M26 and the osmotic stress response

7. Wheat FT protein regulates VRN1 transcription through interactions with FDL2

8. A dimer-specific function of the transcription factor NFATp

9. The role of ATF-2 in oncogenesis

10. Genetic and spatial interactions between FT, TSF and SVP during the early stages of floral induction in Arabidopsis

11. Tissue-specific expression of the PNZIP promoter is mediated by combinatorial interaction of different cis-elements and a novel transcriptional factor

12. Unique status of NIA2 in nitrate assimilation:NIA2 expression is promoted by HY5/HYH and inhibited by PIF4

13. Homo- and heterodimers of tobacco bZIP proteins counteract as positive or negative regulators of transcription during pollen development

14. VIP1: linking Agrobacterium-mediated transformation to plant immunity

15. Gibberellins negatively regulate low temperature-induced anthocyanin accumulation in a HY5/HYH-dependent manner

16. Arabidopsis Clade I TGA Transcription Factors Regulate Plant Defenses in an NPR1-Independent Fashion

17. Basic leucine zipper transcription factor Hac1 binds DNA in two distinct modes as revealed by microfluidic analyses

18. Repression of the Arabidopsis thaliana Jasmonic Acid/Ethylene-Induced Defense Pathway by TGA-Interacting Glutaredoxins Depends on Their C-Terminal ALWL Motif

19. The bZIP Dimer Localizes at DNA Full-Sites Where Each Basic Region Can Alternately Translocate and Bind to Subsites at the Half-Site

20. The Arabidopsis NAC Transcription Factor ANAC096 Cooperates with bZIP-Type Transcription Factors in Dehydration and Osmotic Stress Responses

21. Defects in IRE1 enhance cell death and fail to degrade mRNAs encoding secretory pathway proteins in the Arabidopsis unfolded protein response

22. Effect of Flanking Bases on the DNA Specificity of EmBP-1

23. Molecular interaction of bZIP domains of GBF1, HY5 and HYH in Arabidopsis seedling development

24. Punctum on two different transcription factors regulated by PGC-1α: Nuclear factor erythroid-derived 2-like 2 and nuclear respiratory factor 2

25. Specificity determinants for the abscisic acid response element

26. The Interaction of the Arabidopsis Response Regulator ARR18 with bZIP63 Mediates the Regulation of PROLINE DEHYDROGENASE Expression

27. Multifunctional pentacyclic triterpenoids as adjuvants in cancer chemotherapy: a review

28. Transcriptional circuitry underlying seed coat development in Arabidopsis

29. Transcriptome analysis of newly classified bZIP transcription factors of Brassica rapa in cold stress response

30. A tandem affinity purification tag of TGA2 for isolation of interacting proteins in Arabidopsis thaliana

31. Cocoa intake ameliorates hepatic oxidative stress in young Zucker diabetic fatty rats

32. Dieckol enhances the expression of antioxidant and detoxifying enzymes by the activation of Nrf2–MAPK signalling pathway in HepG2 cells

33. Differential expression of four soybean bZIP genes during Phakopsora pachyrhizi infection

34. Factorial combinations of protein interactions generate a multiplicity of florigen activation complexes in wheat and barley

35. Genome-wide identification, expression profiling, and SSR marker development of the bZIP transcription factor family in Medicago truncatula

36. Transcriptional regulation of secretory capacity by bZip transcription factors

37. Transcriptome Profiling of Wild Arachis from Water-Limited Environments Uncovers Drought Tolerance Candidate Genes

38. The bZIP transcription factor PfZipA regulates secondary metabolism and oxidative stress response in the plant endophytic fungus Pestalotiopsis fici

39. ABA-HYPERSENSITIVE BTB/POZ PROTEIN 1 functions as a negative regulator in ABA-mediated inhibition of germination in Arabidopsis

40. Abscisic acid‐induced gene expression in the liverwort Marchantia polymorpha is mediated by evolutionarily conserved promoter elements

41. Analysis of basic leucine zipper genes and their expression during bud dormancy in peach (Prunus persica)

42. Antidepressant-like activity of red wine phenolic extracts in repeated corticosterone-induced depression mice via BDNF/TrkB/CREB signaling pathway

43. Ectopically expressed glutaredoxin ROXY19 negatively regulates the detoxification pathway in Arabidopsis thaliana

44. Functional Relationship of GBF1 with HY5 and HYH in Genome-Wide Gene Expression in Arabidopsis

45. Genome-wide identification and expression analysis of the bZIP gene family in apple (Malus domestica)

46. Isolation of three B-box zinc finger proteins that interact with STF1 and COP1 defines a HY5/COP1 interaction network involved in light control of development in soybean

47. MafB, a target of microRNA-155, regulates dendritic cell maturation

48. Physiological characterization of drought stress response and expression of two transcription factors and two LEA genes in three Prunus genotypes

49. Tetrachlorobenzoquinone induces Nrf2 activation via rapid Bach1 nuclear export/ubiquitination and JNK-P62 signaling

50. VIP1 is very important/interesting protein 1 regulating touch responses of Arabidopsis

51. Abscisic acid: A key regulator of abiotic stress tolerance in plants

52. Functional characterization of two bZIP transcription factors in Verticillium dahliae

53. Genome-wide identification and analysis of the basic leucine zipper (bZIP) transcription factor gene family in Ustilaginoidea virens

54. Mutations and interactions in human ERα and bZIP proteins: An in silico approach for cell signaling in breast oncology

55. NRF2 overexpression in mesenchymal stem cells induces stem-cell marker expression and enhances osteoblastic differentiation

56. Post‐translational control of ABA signalling: the roles of protein phosphorylation and ubiquitination

57. Seed maturation associated transcriptional programs and regulatory networks underlying genotypic difference in seed dormancy and size/weight in wheat (Triticum aestivum L.)

58. The role of ZIP transporters and group F bZIP transcription factors in the Zn‐deficiency response of wheat (Triticum aestivum)

59. Computational Competitive and Negative Design To Derive a Specific cJun Antagonist

60. Copper excess reduces nitrate uptake by Arabidopsis roots with specific effects on gene expression

61. Expression of the Arabidopsis ABF4 gene in potato increases tuber yield, improves tuber quality and enhances salt and drought tolerance

62. The FT/FD‐dependent initiation of flowering under long‐day conditions in the day‐neutral species Nicotiana tabacum originates from the facultative short‐day ancestor Nicotiana tomentosiformis

63. Genome-wide (ChIP-seq) identification of target genes regulated by BdbZIP10 during paraquat-induced oxidative stress

64. Genome-wide systematic characterization and its regulatory expression reprogramming process of the bZIP transcription factors during trauma response in Camellia sinensis

65. Identification and characterization of finger millet OPAQUE2 transcription factor gene under different nitrogen inputs for understanding their role during accumulation of prolamin seed storage protein

66. Overexpression of a wheat (Triticum aestivum L.) bZIP transcription factor gene, TabZIP6, decreased the freezing tolerance of transgenic Arabidopsis seedlings by down-regulating the expression of CBFs

67. Possible inhibition of Arabidopsis VIP1-mediated mechanosensory signaling by streptomycin

68. Potential in vitro and ex vivo targeting of bZIP53 involved in stress response and seed maturation in Arabidopsis thaliana by five designed peptide inhibitors

69. Salt and drought stress and ABA responses related to bZIP genes from V. radiata and V. angularis

70. Salvianolic acid B inhibits myofibroblast transdifferentiation in experimental pulmonary fibrosis via the up-regulation of Nrf2