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You searched for: Subject bioinformatics Remove constraint Subject: bioinformatics Subject term altitude Remove constraint Subject term: altitude Subject term gene expression regulation Remove constraint Subject term: gene expression regulation Subject term bioinformatics Remove constraint Subject term: bioinformatics Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. Plasma proteome profiling of high-altitude polycythemia using TMT-based quantitative proteomics approach

Author:
Zongkui Wang; Fengjuan Liu; Shengliang Ye; Peng Jiang; Xiaochuan Yu; Jin Xu; Xi Du; Li Ma; Haijun Cao; Chuang Yuan; Yuanzhen Shen; Fangzhao Lin; Rong Zhang; Changqing Li
Source:
Journal of proteomics 2019 v.194 pp. 60-69
ISSN:
1874-3919
Subject:
altitude; bioinformatics; biomarkers; coagulation; complement; data collection; enzyme-linked immunosorbent assay; gene expression regulation; genomics; immune response; inflammation; pathogenesis; patients; polycythemia; protein synthesis; proteins; proteome; proteomics; public health; quantitative analysis; therapeutics; transcriptomics
Abstract:
... High-altitude polycythemia (HAPC) is one of the classic chronic mountain sicknesses and has been a serious public health problem in high-altitude regions. Despite numerous studies on HAPC via genomics or transcriptomics approaches, the pathogenesis of HAPC is still unclear. Here, we performed a TMT- based comparative quantitative proteomics analysis to reveal the changes of plasma proteomics profi ...
DOI:
10.1016/j.jprot.2018.12.031

2. Phosphoproteomic analysis of longissimus lumborum of different altitude yaks

Author:
Yayuan Yang; Ling Han; Qunli Yu; Yongfang Gao; Rende Song; Suonan Zhao
Source:
Meat science 2020 v.162 pp. 108019
ISSN:
0309-1740
Subject:
altitude; bioinformatics; energy metabolism; enzymes; gene expression regulation; glycolysis; longissimus muscle; muscle protein; phosphoproteins; protein phosphorylation; protein synthesis; proteomics; yaks
Abstract:
... Yaks in high altitude regions display good adaptability to hypoxic environment. However, the mechanism involved in regulating muscle protein expression in hypoxic environment is not completely clear yet. To explore the mechanisms modulating postmortem alterations, quantitative phosphoproteomic analysis was performed on muscles of yaks raised at two different altitudes. The results indicated that 4 ...
DOI:
10.1016/j.meatsci.2019.108019

3. Protective mechanism of fdft1 in steroid hormone synthesis pathway in SD rats with acute hypoxic injury

Author:
Xue Lin; Haiyan Wang; Xiaoyan Pu
Source:
Genes & genomics 2020 v.42 no.11 pp. 1319-1326
ISSN:
1976-9571
Subject:
RNA; Western blotting; altitude; bioinformatics; biosynthesis; gene expression regulation; genes; hypoxia; laboratory animals; lungs; males; rats; reverse transcriptase polymerase chain reaction; steroid hormones; transcriptomics; transferases
Abstract:
... BACKGROUND: The acute hypoxic injury caused by the plain population entering the plateau in a short period of time has become the main cause of endangering the health of the people who rush into the plateau. OBJECTIVE: The study aimed to identify the key genes which participate in resisting the acute hypoxic injury in SD Rats by transcriptomic profile analysis. METHODS: 48 Sprague Dawley (SD) male ...
DOI:
10.1007/s13258-020-00999-5