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- Author:
- Sung-Yen Lin; Lin Kang; Jian-Chih Chen; Chau-Zen Wang; Han Hsiang Huang; Mon-Juan Lee; Tsung-Lin Cheng; Chi-Fen Chang; Yi-Shan Lin; Chung-Hwan Chen
- Source:
- Phytomedicine 2019 v.55 pp. 165-171
- ISSN:
- 0944-7113
- Subject:
- alkaline phosphatase; biomechanics; bone density; bone formation; bone marrow; bone morphogenetic proteins; enzyme activity; epigallocatechin gallate; estrogens; females; femur; gene expression; genes; lumbar spine; mechanical properties; messenger RNA; mice; micro-computed tomography; mineralization; rats; stem cells; tibia
- Abstract:
- ... Previously, we found that (−)-epigallocatechin-3-gallate (EGCG) enhanced osteogenic differentiation of murine bone marrow mesenchymal stem cells by increasing the mRNA expression of osteogenesis-related genes, alkaline phosphatase activity and eventually mineralization. We further found EGCG supplementation preserved bone mass and microarchitecture in female rats during estrogen deficiency in the ...
- DOI:
- 10.1016/j.phymed.2018.07.012
- https://doi.org/10.1016/j.phymed.2018.07.012
- Author:
- Sajio Sumida; T. Kitamura; N. Motomura; A. Saito; Evan Hagen; Erik Woods; Arthur W. Rowe
- Source:
- Cryobiology 2013 v.67 no.3 pp. 403
- ISSN:
- 0011-2240
- Subject:
- Limulus; adipocytes; adjuvants; adults; autografting; bags; bone marrow; bone marrow cells; bone marrow transplant; carbon dioxide; clinical trials; cryopreservation; drug therapy; freezing; hematopoiesis; human cell lines; humans; liquids; monocytes; neoplasms; nitrogen; patients; refrigerators; saphenous vein; thawing; viability
- Abstract:
- ... Aim: A frozen allogeneic bone marrow transplantation program was started in 1972, but the initial clinical results were so poor that we switched to frozen autologous bone marrow transplantation (FABMT) to rescue 293 advanced cancer patients who were lethally myelosuppressed due to high dose chemotherapy. However, many unused bone marrow cells from patients who had died due to deterioration of canc ...
- DOI:
- 10.1016/j.cryobiol.2013.09.025
- https://doi.org/10.1016/j.cryobiol.2013.09.025
- Author:
- Aby J Mathew
- Source:
- Cryobiology 2013 v.67 no.3 pp. 412
- ISSN:
- 0011-2240
- Subject:
- biopreservation; blood serum; bone marrow; case studies; cryopreservation; good manufacturing practices; manufacturing; medicine; risk; transportation
- Abstract:
- ... Cellular therapies and regenerative medicine utilize cell and tissue products sourced from blood, bone marrow, and various tissues. The clinical and commercial success of these products is potentially impacted by stability limitations, which include transport of the source material and biopreservation of the final cell or tissue product (either frozen or non-frozen). Traditional isotonic/extracell ...
- DOI:
- 10.1016/j.cryobiol.2013.09.058
- https://doi.org/10.1016/j.cryobiol.2013.09.058
- Author:
- Valerie Steenwinckel; R. Awidekian; D. Daro; O. Link; I. Saccavino; G. Deblandre; A. Sunnanväder; P. De Waele
- Source:
- Cryobiology 2013 v.67 no.3 pp. 412-413
- ISSN:
- 0011-2240
- Subject:
- Mycoplasma; blood; bone marrow; bone marrow cells; clinical trials; commercialization; cryopreservation; drugs; endotoxins; extended shelf life; heart; heart diseases; liquids; manufacturing; mesenchymal stromal cells; patients; stem cells; thawing; therapeutics; viability; washing
- Abstract:
- ... Cardio3 BioSciences (C3BS) is a Belgian biotechnology company focused on the discovery, development and commercialization of regenerative and protective therapies for the treatment of cardiac diseases. The challenge is to provide the injured heart with stem cells that have the capacity to act as if they are cardiac-specific progenitor cells. Therefore, C3BS developed a GMP therapy based on autolog ...
- DOI:
- 10.1016/j.cryobiol.2013.09.060
- https://doi.org/10.1016/j.cryobiol.2013.09.060
- Author:
- Tim Morris; Christopher J. Hewitt; Karen Coopman,
- Source:
- Cryobiology 2013 v.67 no.3 pp. 430-431
- ISSN:
- 0011-2240
- Subject:
- alkaline phosphatase; ambient temperature; blood serum; bone marrow; cattle; cryopreservation; cryoprotectants; culture media; cytotoxicity; death; freezing; glycerol; humans; industry; medicine; storage time; tissue culture; viability
- Abstract:
- ... Regenerative medicine is an emerging industry and there is currently limited knowledge related to the long term storage, shipment and preservation of cell therapies. The most commonly used method for long term storage is cryopreservation, but there are problems associated with protocol definition and reagent toxicity. Cryopreservation is a peripheral but vital process in the development of allogen ...
- DOI:
- 10.1016/j.cryobiol.2013.09.121
- https://doi.org/10.1016/j.cryobiol.2013.09.121
- Author:
- R.A. Matulka; T. Chan; R. Green; J.R. Carney; S. Franklin; P. Licari
- Source:
- Toxicology reports 2016 v.3 pp. 123-134
- ISSN:
- 2214-7500
- Subject:
- Escherichia coli; Garcinia indica; Prototheca moriformis; Salmonella Typhimurium; body weight; bone marrow; chromosome aberrations; diet study techniques; eggs; fermentation; food consumption; food industry; genotoxicity; hematology; histopathology; microalgae; mutagens; mutation; toxicology; urinalysis
- Abstract:
- ... Microalgae are increasingly being utilized as food ingredients for a variety of applications, including as sources of protein, egg and dairy substitutes, and cooking oils. The dietary safety of a new structuring fat produced using a heterotrophic fermentation process by a strain of Prototheca moriformis was evaluated in a 13-week dietary toxicity study and compared with kokum fat, a structuring fa ...
- DOI:
- 10.1016/j.toxrep.2015.12.006
- https://doi.org/10.1016/j.toxrep.2015.12.006
- Author:
- Andreas Sputtek; Evgeny Klyuchnikov; Nikolaus Kröger; Sven Peine; Arthur W. Rowe
- Source:
- Cryobiology 2012 v.65 no.3 pp. 342-343
- ISSN:
- 0011-2240
- Subject:
- anticoagulants; bags; blood; bone marrow; cell culture; cooling; cryopreservation; cryoprotectants; dimethyl sulfoxide; drug therapy; freezing; germ cells; granulocyte colony-stimulating factor; heat; heparin; irradiation; leukemia; liver; myeloma; nitrogen; patients; refrigerators; starch; stem cells; surface antigens; temperature; thawing; thermal properties; toxicity; umbilical cord; vapors; viability; Europe
- Abstract:
- ... Hematopoietic progenitor cells (HPC) are primitive pluripotent cells capable of self renewal as well as of differentiation and maturation into all hematopoietic lineages. They can be found in bone marrow, in fetal liver, in umbilical cord blood, and in the mononuclear cell fraction of circulating blood. They are characterized by their colony-forming capacities in different in vitro cell culture as ...
- DOI:
- 10.1016/j.cryobiol.2012.07.013
- https://doi.org/10.1016/j.cryobiol.2012.07.013
- Author:
- Slavko Mojsilović; Aleksandra Krstić; Vesna Ilić; Ivana Okić-Đorđević; Jelena Kocić; Drenka Trivanović; Juan Francisko Santibañez; Gordana Jovčić; Diana Bugarski
- Source:
- Cell and tissue research 2011 v.346 no.3 pp. 305-316
- ISSN:
- 0302-766X
- Subject:
- additive effect; biocompatibility; bone marrow; cell proliferation; fibroblast growth factor 2; fibroblasts; interleukins; mice; mitogen-activated protein kinase; models; signal transduction; stem cells; tissue engineering
- Abstract:
- ... The mouse is a suitable experimental model to study the biology of mesenchymal stem cells (MSCs), as well as to be used in biocompatibility studies and tissue engineering models. However, the isolation and purification of murine MSCs is far more challenging than their counterparts from other species. In this study, we isolated, expanded and characterized mouse MSCs from bone marrow (BM-MSCs). Addi ...
- DOI:
- 10.1007/s00441-011-1284-5
- PubMed:
- 22160457
- https://doi.org/10.1007/s00441-011-1284-5
- Author:
- Xiaodong Zhang; Ligang Liu; Danyang Liu; Yongtao Li; Jun He; Lei Shen
- Source:
- Computational and Structural Biotechnology Journal 2022 v.20 pp. 3864-3873
- ISSN:
- 2001-0370
- Subject:
- angiogenesis; apoptosis; biotechnology; bone marrow; cell movement; females; humans; menopause; protein synthesis
- Abstract:
- ... Estrogen is an important hormone affecting angiogenesis in women and is important for female physical development. Menopausal women are prone to serious cardiovascular and cerebrovascular diseases when estrogen is significantly reduced. Bone marrow mesenchymal stem cells (BMSC) have potential roles in processes such as angiogenesis and remodeling. This study is to investigate the effect of 17β-est ...
- DOI:
- 10.1016/j.csbj.2022.07.028
- https://doi.org/10.1016/j.csbj.2022.07.028
- Author:
- Wenbi Zhang; Xiong Li; He Li; Xiang Lu; Junling Chen; Lu Li; Xiaoxi Sun; Congjian Xu
- Source:
- Biochemical and biophysical research communications 2020 v.530 no.2 pp. 381-388
- ISSN:
- 0006-291X
- Subject:
- antagonists; bone marrow; cell movement; chemokines; chemotaxis; coculture; endometriosis; endometrium; gene expression; gene ontology; mesenchymal stromal cells; quantitative polymerase chain reaction; research; secretion; stem cells
- Abstract:
- ... Bone marrow-derived cells engraft to the uterine endometrium and contribute to endometriosis. This study sought to further confirm that estrogen can promote the migration of bone marrow mesenchymal stem cells (BMSCs) and to investigate the function of estrogen on the secretion of chemokines during BMSC migration. BMSCs were treated with or without 17β-estradiol, cultured with or without endometria ...
- DOI:
- 10.1016/j.bbrc.2020.07.135
- https://doi.org/10.1016/j.bbrc.2020.07.135
- Author:
- Minjie Luo; Hao Wang; Ke Liu; Meidong Liu; Sipin Tan; Yaxi Zhu; Huali Zhang
- Source:
- Biochemical and biophysical research communications 2022 v.620 pp. 21-28
- ISSN:
- 0006-291X
- Subject:
- antagonists; bone marrow; humans; liver; macrophages; phenotype; prognosis; protective effect; research
- Abstract:
- ... Myeloid-derived suppressor cells (MDSCs) mobilize and migrate from bone marrow to peripheral tissues or immune organs, which is associated with poor prognosis in sepsis. Intervention of MDSCs might be a potential target for the effective treatment of sepsis. In the present study, we demonstrated that IL-1R1 blockade with either recombinant human IL-1R antagonist Anakinra or IL-1R1 deficiency had a ...
- DOI:
- 10.1016/j.bbrc.2022.06.038
- https://doi.org/10.1016/j.bbrc.2022.06.038
- Author:
- Nicola Stefano Fracchiolla; Claudio Annaloro; Francesca Guidotti; Bruno Fattizzo; Agostino Cortelezzi
- Source:
- Toxicology 2016 v.374 pp. 60-68
- ISSN:
- 0300-483X
- Subject:
- bone marrow; epidemiological studies; hematologic diseases; hematopoiesis; humans; myeloma; sarcoma; stem cells; tetrachlorodibenzo-p-dioxin; xenobiotics
- Abstract:
- ... Dioxin exposure and its effect on hematopoiesis and cancer have been largely investigated in both human and non-human settings. Here we systematically reviewed literature to address the question of what we know about TCDD biology and exposure. Most effects are due to TCDD interaction with a receptor of xenobiotics called AHR, which is ubiquitously represented and also works on hematopoietic myeloi ...
- DOI:
- 10.1016/j.tox.2016.10.007
- https://doi.org/10.1016/j.tox.2016.10.007
- Author:
- Paulomi Ghosh; Arun Prabhu Rameshbabu; Nantu Dogra; Santanu Dhara
- Source:
- RSC advances 2014 v.4 no.37 pp. 19516-19524
- ISSN:
- 2046-2069
- Subject:
- adhesion; adsorption; alkaline phosphatase; animal models; bone formation; bone marrow; calcium; cell proliferation; chemical bonding; chitosan; crosslinking; extracellular matrix; femur; glucosamine; histology; humans; hydrophobicity; imines; in vivo studies; mesenchymal stromal cells; neutralization; osteocalcin; pH; polymers; rabbits; secretion; sodium hydroxide; tensile strength; tissue engineering
- Abstract:
- ... Chitosan fibers were fabricated via pH induced neutralization and precipitation in a 5 w/v% NaOH bath. Intermolecular covalent crosslinking of these fibers were performed through imine linkages between the glucosamine units of polymers and the dialdehyde groups of 2,5-dimethoxy-2,5-dihydrofuran at 60 °C, pH 2.2. The covalently crosslinked fibers demonstrated improved tensile strength, stiffness, h ...
- DOI:
- 10.1039/c4ra01971g
- https://doi.org/10.1039/c4ra01971g
- Author:
- Mario Martinez Soldevilla; Helena Villanueva; Maurizio Bendandi; Susana Inoges; Ascensión López-Díaz de Cerio; Fernando Pastor
- Source:
- Biomaterials 2015 v.67 pp. 274-285
- ISSN:
- 0142-9612
- Subject:
- B-lymphocytes; abnormal development; agonists; antagonists; antibodies; antineoplastic activity; bone marrow; drug therapy; drugs; immunosuppression; immunotherapy; lymphoma; messenger RNA; neoplasm cells; oligonucleotides; patients; radiotherapy
- Abstract:
- ... Recent studies have underscored the importance of immunomodulatory antibodies in the treatment of solid and hematological tumors. ODN-Aptamers are rising as a novel class of drugs that can rival therapeutic antibodies. The success of some of the current cancer immunotherapy approaches in oncological patients depends on the intrinsic antigenicity of each tumor as has recently been disclosed, and it ...
- DOI:
- 10.1016/j.biomaterials.2015.07.020
- https://doi.org/10.1016/j.biomaterials.2015.07.020
- Author:
- S. Sumida; T. Kitamura; N. Motomura; A. Saito
- Source:
- Cryobiology 2012 v.65 no.3 pp. 345-346
- ISSN:
- 0011-2240
- Subject:
- autografting; bone marrow; bone marrow cells; containers; cryopreservation; lymphocytes; nitrogen; patients; stem cells; umbilical cord; viability
- Abstract:
- ... AIM: This study was performed to confirm viability and differentiation in culture of bone marrow cells cryopreserved since 1972. Materials and Methods were presented previously as part 1. RESULTS AND CONCLUSION: Bone marrow cells from 293 advanced cancer patients were collected and frozen in 1972 for allogeneic and after 1982 for autologous transplantation. Containers with bone marrow which were n ...
- DOI:
- 10.1016/j.cryobiol.2012.07.021
- https://doi.org/10.1016/j.cryobiol.2012.07.021
- Author:
- E. Rink; H. French; E. Watson; C. Aurich; F. X. Donadeu
- Source:
- Reproduction, fertility, and development 2016 v.28 no.2 pp. 243-244
- ISSN:
- 1031-3613
- Subject:
- adipose tissue; bone marrow; cultured cells; deoxyribonuclease I; dissociation; endometrium; erythrocytes; fetal bovine serum; flow cytometry; horses; humans; microbial collagenase; reproduction; stromal cells; surgery; t-test; Illinois
- Abstract:
- ... Equine mesenchymal stromal cells (MSC) are mainly harvested from bone marrow and adipose tissue, requiring surgical procedures. Although human endometrium is known to harbor mesenchymal precursor cells, the presence of MSC in equine endometrium, a dynamic tissue, has not been investigated. This study reports for the first time the culture and characterisation of MSC from equine endometrium compare ...
- DOI:
- 10.1071/RDv28n2Ab223
- https://doi.org/10.1071/RDv28n2Ab223
- Author:
- Huaiyong Zhang; Maryam Majdeddin; Djoere Gaublomme; Bernard Taminiau; Matthieu Boone; Dirk Elewaut; George Daube; Iván Josipovic; Keying Zhang; Joris Michiels
- Source:
- Journal of animal science and biotechnology 2021 v.12 no.1 pp. 104
- ISSN:
- 2049-1891
- Subject:
- 25-hydroxycholecalciferol; T-lymphocytes; ambient temperature; biotechnology; blood serum; bone density; bone formation; bone health; bone marrow; bone resorption; cathepsin K; collagen; crosslinking; dysbiosis; heat; heat stress; ileum; inflammation; mineral content; osteoclasts; permeability; therapeutics; tibia
- Abstract:
- ... BACKGROUND: Alterations in ambient temperature have been associated with multiple detrimental effects on broilers such as intestinal barrier disruption and dysbiosis resulting in systemic inflammation. Inflammation and 25-hydroxycholecalciferol (25-OH-D₃) have shown to play a negative and positive role, respectively, in the regulation of bone mass. Hence the potential of 25-OH-D₃ in alleviating he ...
- DOI:
- 10.1186/s40104-021-00627-6
- https://doi.org/10.1186/s40104-021-00627-6
- Author:
- Lishan Zhang; Yinping Lv; Guozhe Xian; Yanliang Lin
- Source:
- Biochemical and biophysical research communications 2017 pp. -
- ISSN:
- 0006-291X
- Subject:
- T-lymphocytes; binding capacity; bone marrow; chromatin; immune response; ligands; lipid metabolism; macrophage colony-stimulating factor; macrophages; mice; monocytes; precipitin tests; transcription (genetics); transcription factor NF-kappa B
- Abstract:
- ... 25-hydroxycholesterol (25-HC) is implicated in many processes, including lipid metabolism and the immune response. However, the role of 25-HC in RANKL-induced osteoclastogenesis remains largely unknown. Our results showed that 25-HC inhibited miR-139-5p expression in mouse bone marrow macrophages (BMMs) cultured in receptor activator of NF-κB ligand (RANKL) and monocyte macrophage colony-stimulati ...
- DOI:
- 10.1016/j.bbrc.2017.02.118
- https://doi.org/10.1016/j.bbrc.2017.02.118
- Author:
- Hyeon-Yeong Kim; Eun-Sang Cho
- Source:
- Toxicology reports 2018 v.5 pp. 213-219
- ISSN:
- 2214-7500
- Subject:
- blood sampling; bone marrow; breathing; erythrocytes; females; food intake; hazard characterization; histopathology; inhalation toxicity; males; micronucleus tests; mortality; no observed adverse effect level; respiratory system; tissue weight
- Abstract:
- ... The 28-day repeated inhalation study was applied for hazard assessment of 3-methoxybutyl chloroformate (3-MBCF) in Sprague Dawley rats. Groups of five rats per sex were exposed 6 h/day, 5 days per week for 4 weeks to test substance concentration (ranging from 3 to 12 ppm) using a whole-body exposure system. At the terminal sacrifice, following blood collection and gross pathological examination, o ...
- DOI:
- 10.1016/j.toxrep.2017.12.007
- https://doi.org/10.1016/j.toxrep.2017.12.007
- Author:
- Robert L. Sprando; Miriam E. Mossoba; Thomas Black; Zachary Keltner; Sanah Vohra; Nicholas Olejnik; Howard Toomer; Cynthia Stine; Eric Evans; Jessica L. Sprando; Martine Ferguson
- Source:
- Food and chemical toxicology 2017 v.106 pp. 558-567
- ISSN:
- 0278-6915
- Subject:
- acute toxicity; blood serum; body weight changes; bone marrow; dietary exposure; dose response; exposure duration; females; formalin; histopathology; intestines; kidneys; liver; necropsy; rats; spleen; stomach; thymus gland; toxicology
- Abstract:
- ... The acute oral toxicity of diglycolic acid (DGA) was evaluated. Groups of female rats (n = 8 rats/group) received 28 consecutive daily single doses of 0.3, 1.0, 3.0, 10.0, 30.0, 100.0 or 300.0 mg DGA/kg body weight by gastric intubation. One group of animals served as vehicle control. Tissues and blood serum were collected at necropsy on day 29. Select organs were weighed and fixed in formalin for ...
- DOI:
- 10.1016/j.fct.2017.03.047
- https://doi.org/10.1016/j.fct.2017.03.047
- Author:
- Verónica Alcolea; Esther Moreno; Mikel Etxebeste-Mitxeltorena; Iñigo Navarro-Blasco; Elena González-Peñas; Antonio Jiménez-Ruiz; Juan Manuel Irache; Carmen Sanmartín; Socorro Espuelas
- Source:
- Acta tropica 2021 v.215 pp. 105801
- ISSN:
- 0001-706X
- Subject:
- animal models; bone marrow; enzymes; human cell lines; intestines; liver; metabolites; oral administration; parasite load; permeability; selenium compounds; spleen; visceral leishmaniasis
- Abstract:
- ... Compounds 1 and 2 (selenocyanate and diselenide derivatives, respectively) were evaluated for their potential use in vivo against visceral leishmaniasis (VL). Both entities showed low cytoxicity in vitro in Vero and Caco-2 cell lines. However, the compounds were not suitable for their oral administration, since they exhibited poor values of intestinal permeability in vitro. Microsomal stability as ...
- DOI:
- 10.1016/j.actatropica.2020.105801
- https://doi.org/10.1016/j.actatropica.2020.105801
- Author:
- Yi-Chen Li; Jyh-Horng Wang; Li-Kai Tsai; Yun-An Chen; Ta-Chau Chang; Pei-Jen Lou; Tai-Horng Young
- Source:
- Journal of materials chemistry B 2015 v.3 no.10 pp. 2067-2074
- ISSN:
- 2050-7518
- Subject:
- bone marrow; cerebral cortex; chemistry; cytotoxicity; fibroblasts; fluorescence; mesenchymal stromal cells; models; neuroglia; neurons; neurophysiology; rats; stem cells; tissue repair
- Abstract:
- ... Until now, there has been no appropriate marker to specifically and effectively label living neural stem/precursor cells (NSPCs) to investigate NSPC migration and differentiation. Therefore, the purpose of this study was to develop a specific method for tracking NSPCs by a cell marker, 3,6-bis(1-methyl-4-vinylpyridinium)-carbazole diiodide (BMVC). It was found that the bright fluorescence spots co ...
- DOI:
- 10.1039/c4tb01903b
- https://doi.org/10.1039/c4tb01903b
- Author:
- Yingxiao Fu; Yihui Wang; Dequn Niu; Baoding Tang; Yingji Mao; Xishuai Tong; Honggang Dai; Xianfu Liu; Chuang Li; Xuemin Sun; Zheng Gong; Xue Li; Yinjiu Huang; Wei Xue
- Source:
- Poultry science 2019 v.98 no.4 pp. 1854-1860
- ISSN:
- 0032-5791
- Subject:
- acid phosphatase; bone marrow; cell viability; ducks; embryo (animal); ligands; macrophage colony-stimulating factor; osteoclasts; osteoporosis; phalloidine; resorption; staining; transcription factor NF-kappa B
- Abstract:
- ... This study determined the influence of 3-(4-methoxyl)-1-(2-(4-coumarin)prop)-2-en-1-one (MCPEO) on the differentiation of Gaoyou duck embryo osteoclasts cultured in vitro. Bone marrow mononuclear cells (BM-MNCs) were harvested from 23-day-old Gaoyou duck embryos and induced by receptor activator of nuclear factor κB ligand (RANKL) and macrophage colony-stimulating factor (M-CSF) in the presence of ...
- DOI:
- 10.3382/ps/pey542
- https://doi.org/10.3382/ps/pey542
- Author:
- A. Thiel; A.C.M. Schoenmakers; I.A.J. Verbaan; E. Chenal; S. Etheve; P. Beilstein
- Source:
- Food and chemical toxicology 2019 v.123 pp. 566-573
- ISSN:
- 0278-6915
- Subject:
- Ames test; bone marrow; genotoxicity; metabolites; micronucleus tests; mutagenicity; mutagens; mutation; protocols; rats
- Abstract:
- ... 3-NOP (3-nitroxy-propanol) is a new development compound which reduces methane emission from ruminating animals. For registration purposes with emphasis on EU and North America data requirements, mutagenic and genotoxic potential was assessed following OECD protocols and respective guidance documents. 3-NOP mutagenicity and genotoxicity testing raised no flags with regard to these endpoints. In si ...
- DOI:
- 10.1016/j.fct.2018.11.010
- https://doi.org/10.1016/j.fct.2018.11.010
- Author:
- Aurore Lamberet; Octavie Rostan; Sarah Dion; Aurélien Jan; Hélène Guegan; Christelle Manuel; Michel Samson; Jean-Pierre Gangneux; Florence Robert-Gangneux
- Source:
- Parasites & vectors 2020 v.13 no.1 pp. 320
- ISSN:
- 1756-3305
- Subject:
- Leishmania donovani; blood serum; bone marrow; disease progression; gene expression; histology; immune response; interleukin-12; interleukin-13; interleukin-4; interleukin-5; liver; mice; parasites; spleen
- Abstract:
- ... BACKGROUND: During infection with Leishmania donovani, parasite control is linked to the systemic Th1 immune response, but in infected organs (liver, spleen and bone marrow), the response differs according to the micro-environment. The pleiomorphic cytokine interleukin-33 (IL-33) exerts various roles during infection, either protective or detrimental. In this study, we explored the role of IL-33 i ...
- DOI:
- 10.1186/s13071-020-04190-3
- https://doi.org/10.1186/s13071-020-04190-3
- Author:
- Mengmeng Zhao; Yongguang Hu; Juanjuan Shou; Shao Bo Su; Jianhua Yang; Tianshu Yang
- Source:
- Biochemical and biophysical research communications 2016 pp. -
- ISSN:
- 0006-291X
- Subject:
- Listeria monocytogenes; anti-inflammatory activity; apoptosis; bacteria; blood serum; bone marrow; colony-stimulating factors; immune response; listeriosis; liver; macrophages; mice; microbial load; models
- Abstract:
- ... Listeria monocytogenes is a Gram-positive intracellular bacterium that was transmitted through contaminated food and causes sepsis and even death. IL-37 has been described as an important anti-inflammatory factor, but little is known about the function of IL-37 in host defense against Liseria monocytogenes (Lm) infection. In mice model of systemic infection, we found that mice treated with IL-37 w ...
- DOI:
- 10.1016/j.bbrc.2016.11.002
- https://doi.org/10.1016/j.bbrc.2016.11.002
- Author:
- Zhou Xuan; Zhu Wei; Nowicki Margaret; Miao Shida; Cui Haitao; Holmes Benjamin; Glazer Robert I.; Zhang Lijie Grace
- Source:
- ACS Applied Materials & Interfaces 2016 v.8 no.44 pp. 30017-30026
- ISSN:
- 1944-8252
- Subject:
- alkaline phosphatase; biomimetics; bioprinting; bone marrow; breast neoplasms; coculture; gelatin; humans; hydrogels; hydroxyapatite; metastasis; models; nanocrystals; osteoblasts; secretion; stem cells; stromal cells; vascular endothelial growth factors
- Abstract:
- ... Metastasis is one of the deadliest consequences of breast cancer, with bone being one of the primary sites of occurrence. Insufficient 3D biomimetic models currently exist to replicate this process in vitro. In this study, we developed a biomimetic bone matrix using 3D bioprinting technology to investigate the interaction between breast cancer (BrCa) cells and bone stromal cells (fetal osteoblasts ...
- DOI:
- 10.1021/acsami.6b10673
- https://doi.org/10.1021/acsami.6b10673
- Author:
- Jun Yin; Mengling Yan; Yancheng Wang; Jianzhong Fu; Hairui Suo
- Source:
- ACS applied materials & interfaces 2018 v.10 no.8 pp. 6849-6857
- ISSN:
- 1944-8252
- Subject:
- bioprinting; bone marrow; cell viability; crosslinking; drugs; gelatin; hydrogels; in vitro culture; materials science; mechanical properties; rheology; stem cells; tissue engineering
- Abstract:
- ... Methacrylated gelatin (GelMA) has been widely used as a tissue-engineered scaffold material, but only low-concentration GelMA hydrogels were found to be promising cell-laden bioinks with excellent cell viability. In this work, we reported a strategy for precise deposition of 5% (w/v) cell-laden GelMA bioinks into controlled microarchitectures with high cell viability using extrusion-based three-di ...
- DOI:
- 10.1021/acsami.7b16059
- https://doi.org/10.1021/acsami.7b16059
- Author:
- Qing-Qing Qiu; Paul Ducheyne; Portonovo S. Ayyaswamy
- Source:
- In vitro cellular & developmental biology 2001 v.37 no.3 pp. 157-165
- ISSN:
- 1071-2690
- Subject:
- apatite; biodegradability; bone marrow; cell culture; drug delivery systems; extracellular matrix; glass; in vitro studies; microgravity; mineralization; osteoblasts; polymers; stromal cells; tissue engineering
- Abstract:
- ... Three-dimensional (3D) osteoblast cell cultures were obtained in rotating-wall vessels (RWV), simulating microgravity. Three types of bioactive microcarriers, specifically modified bioactive glass particles, bioceramic hollow microspheres, and biodegradable bioactive glass-polymer composite microspheres, were developed and used with osteblasts. The surfaces of composite microspheres fully transfor ...
- DOI:
- 10.1290/1071-2690(2001)037<0157:BTEWBM>2.0.CO;2
- https://doi.org/10.1290/1071-2690(2001)037<0157:BTEWBM>2.0.CO;2
- Author:
- Yihan Wang; Changnan Xie; Zhiming Zhang; Haining Liu; Haixia Xu; Ziyue Peng; Chun Liu; Jianjun Li; Chengqiang Wang; Tao Xu; Lixin Zhu
- Source:
- ACS applied materials & interfaces 2022 v.14 no.26 pp. 29506-29520
- ISSN:
- 1944-8252
- Subject:
- bone formation; bone marrow; hypoxia; ischemia; microparticles; models; rabbits; three-dimensional printing; tissue repair
- Abstract:
- ... The repair of large bone defects remains a challenging problem in bone tissue engineering. Ischemia and hypoxia in the bone defect area make it difficult for seed cells to survive and differentiate, which fail to perform effective tissue regeneration. Current oxygen-producing materials frequently encounter problems such as a rapid degradation rate, insufficient mechanical properties, difficult mol ...
- DOI:
- 10.1021/acsami.2c04378
- https://doi.org/10.1021/acsami.2c04378
- Author:
- Bracaglia Laura G.; Messina Michael; Winston Shira; Kuo Che-Ying; Lerman Max; Fisher John P.
- Source:
- Biomacromolecules 2017 v.18 no.11 pp. 3802-3811
- ISSN:
- 1526-4602
- Subject:
- binding sites; biobased products; bone marrow; collagen; endothelial cells; fibronectins; glycosaminoglycans; heart; hydrogels; interleukin-1beta; macrophages; mechanical properties; models; pericardium; phenotype; polyethylene glycol; primary amines; printers; rats; structural proteins; tissue engineering; tissue repair; tumor necrosis factor-alpha
- Abstract:
- ... Vascular grafts that can support total replacement and maintenance by the body of the injured vessel would improve outcomes of major surgical reconstructions. Building scaffolds using components of the native vessel can encourage biological recognition by native cells as well as mimic mechanical characteristics of the native vessel. Evidence is emerging that incorporating predetermined building-bl ...
- DOI:
- 10.1021/acs.biomac.7b01165
- https://doi.org/10.1021/acs.biomac.7b01165
- Author:
- Xuan Zhou; Margaret Nowicki; Haitao Cui; Wei Zhu; Xiuqi Fang; Shida Miao; Se-Jun Lee; Michael Keidar; Lijie Grace Zhang
- Source:
- Carbon 2017 v.116 pp. 615-624
- ISSN:
- 0008-6223
- Subject:
- bioprinting; bone marrow; cartilage; chondrogenesis; collagen; ethylene glycol; genes; glycosaminoglycans; graphene; graphene oxide; humans; medicine; nanomaterials; stem cells; tissue engineering
- Abstract:
- ... Articular cartilage repair and regeneration are a challenging problem worldwide due to the extremely weak inherent regenerative capacity of cartilaginous tissue. As an emerging tissue engineering scaffold fabrication technology, 3D bioprinting has shown great promise in fabricating customizable artificial tissue matrices with hierarchical structures. The goal of the present study is to investigate ...
- DOI:
- 10.1016/j.carbon.2017.02.049
- https://doi.org/10.1016/j.carbon.2017.02.049
- Author:
- Isabelle Leisten; Rafael Kramann; Mónica S. Ventura Ferreira; Manfred Bovi; Sabine Neuss; Patrick Ziegler; Wolfgang Wagner; Ruth Knüchel; Rebekka K. Schneider
- Source:
- Biomaterials 2012 v.33 no.6 pp. 1736-1747
- ISSN:
- 0142-9612
- Subject:
- bone marrow; coculture; collagen; gels; hematopoiesis; homeostasis; migratory behavior; models; phenotype; stem cells; umbilical cord
- Abstract:
- ... Here, we propose a collagen-based three-dimensional (3D) environment for hematopoietic stem and progenitor cells (HPC) with mesenchymal stem cells (MSC) derived either from bone marrow (BM) or umbilical cord (UC), to recapitulate the main components of the BM niche. Mechanisms described for HPC homeostasis were systematically analyzed in comparison to the conventional liquid HPC culture. The 3D-cu ...
- DOI:
- 10.1016/j.biomaterials.2011.11.034
- https://doi.org/10.1016/j.biomaterials.2011.11.034
- Author:
- Carlos Bello-Rodriguez; Olga Wittig; Dylana Diaz-Solano; Pura Bolaños; Jose E. Cardier
- Source:
- Cell and tissue research 2020 v.382 no.3 pp. 499-507
- ISSN:
- 0302-766X
- Subject:
- area; assays; blood cells; bone marrow; cell structures; collagen; confocal microscopy; flow cytometry; hematopoiesis; hematopoietic stem cells; histology; in vivo studies; mesenchymal stromal cells; mice; microparticles; models; research; viability
- Abstract:
- ... The hematopoietic niche is a specialized microenvironment that supports the survival, proliferation and differentiation of hematopoietic stem progenitor cells (HSPCs). Three-dimensional (3D) models mimicking hematopoiesis might allow in vitro and in vivo studies of the hematopoietic (HP) process. Here, we investigate the capacity of a 3D construct based on non-adherent murine bone marrow mononucle ...
- DOI:
- 10.1007/s00441-020-03265-y
- https://doi.org/10.1007/s00441-020-03265-y
- Author:
- Ting Guo; Maeesha Noshin; Hannah B. Baker; Evin Taskoy; Sean J. Meredith; Qinggong Tang; Julia P. Ringel; Max J. Lerman; Yu Chen; Jonathan D. Packer; John P. Fisher
- Source:
- Biomaterials 2018 v.185 pp. 219-231
- ISSN:
- 0142-9612
- Subject:
- adolescents; adults; bone marrow; cartilage; chondrocytes; collagen; models; staining; surgery; tomography
- Abstract:
- ... While articular cartilage defects affect millions of people worldwide from adolescents to adults, the repair of articular cartilage defects still remains challenging due to the limited endogenous regeneration of the tissue and poor integration with implants. In this study, we developed a 3D-printed scaffold functionalized with aggrecan that supports the cellular fraction of bone marrow released fr ...
- DOI:
- 10.1016/j.biomaterials.2018.09.022
- PubMed:
- 30248646
- PubMed Central:
- PMC6186501
- https://doi.org/10.1016/j.biomaterials.2018.09.022
- Author:
- Senem Buyuksungur; Tugba Endogan Tanir; Arda Buyuksungur; Ezgi Irem Bektas; Gamze Torun Kose; Deniz Yucel; Tahsin Beyzadeoglu; Engin Cetinkaya; Cagri Yenigun; Ergin Tönük; Vasif Hasirci; Nesrin Hasirci
- Source:
- Biomaterials science 2017 v.5 no.10 pp. 2144-2158
- ISSN:
- 2047-4849
- Subject:
- bone density; bone marrow; cytotoxicity; femur; hydrophilicity; hydroxyapatite; inflammation; micro-computed tomography; models; patients; porosity; propylene; rabbits; stem cells; surgery; tissue repair
- Abstract:
- ... A large variety of approaches have been used to treat large and irregular shaped bone defects with less than optimal success due to material or design issues. In recent years patient specific constructs prepared by additive manufacturing provided a solution to the need for shaping implants to fit irregular defects in the surgery theater. In this study, cylindrical disks of poly(ε-caprolactone) (PC ...
- DOI:
- 10.1039/c7bm00514h
- https://doi.org/10.1039/c7bm00514h
- Author:
- Ziyue Peng; Chengqiang Wang; Chun Liu; Haixia Xu; Yihan Wang; Yang Liu; Yunteng Hu; Jianjun Li; Yanglei Jin; Cong Jiang; Liangle Liu; Jiasong Guo; Lixin Zhu
- Source:
- Journal of materials chemistry B 2021 v.9 no.28 pp. 5698-5710
- ISSN:
- 2050-7518
- Subject:
- adhesion; bone formation; bone marrow; cell viability; chemistry; coculture; histology; hypoxia; ischemia; magnesium; models; normoxia; oxygen; phosphates; rats; three-dimensional printing
- Abstract:
- ... Ischemia and hypoxia in the bone defect area remain an intractable problem when treating large bone defects. Thus, oxygen-releasing biomaterials have been widely researched in recent years. Magnesium peroxide (MgO₂) can release oxygen (O₂), and magnesium ions (Mg²⁺), simultaneously, which is seen to have significant potential in bone substitutes. In this study, we used 3D printing technology to fa ...
- DOI:
- 10.1039/d1tb00178g
- https://doi.org/10.1039/d1tb00178g
- Author:
- Pilar de la Puente; Barbara Muz; Rebecca C. Gilson; Feda Azab; Micah Luderer; Justin King; Samuel Achilefu; Ravi Vij; Abdel Kareem Azab
- Source:
- Biomaterials 2015 v.73 pp. 70-84
- ISSN:
- 0142-9612
- Subject:
- bone marrow; cell proliferation; drugs; endothelial cells; experimental design; flow cytometry; image analysis; immunohistochemistry; models; multiple drug resistance; myeloma; oxygen; pathophysiology; patients; screening; stromal cells; tissue culture; tissue engineering
- Abstract:
- ... Multiple myeloma (MM) is the second most prevalent hematological malignancy and it remains incurable despite the introduction of several novel drugs. The discrepancy between preclinical and clinical outcomes can be attributed to the failure of classic two-dimensional (2D) culture models to accurately recapitulate the complex biology of MM and drug responses observed in patients. Experimental desig ...
- DOI:
- 10.1016/j.biomaterials.2015.09.017
- PubMed:
- 26402156
- PubMed Central:
- PMC4917006
- https://doi.org/10.1016/j.biomaterials.2015.09.017
39. 3D-Printed Bioactive Ca3SiO5 Bone Cement Scaffolds with Nano Surface Structure for Bone Regeneration
- Author:
- Yang Chen; Wang Xiaoya; Ma Bing; Zhu Haibo; Huan Zhiguang; Ma Nan; Wu Chengtie; Chang Jiang
- Source:
- ACS Applied Materials & Interfaces 2017 v.9 no.7 pp. 5757-5767
- ISSN:
- 1944-8252
- Subject:
- ambient temperature; bioactive properties; biocompatible materials; bone marrow; cement; ceramics; drugs; engineering; in vivo studies; models; physicochemical properties; rats; shrinkage; silicates; stem cells; strength (mechanics)
- Abstract:
- ... Silicate bioactive materials have been widely studied for bone regeneration because of their eminent physicochemical properties and outstanding osteogenic bioactivity, and different methods have been developed to prepare porous silicate bioactive ceramics scaffolds for bone-tissue engineering applications. Among all of these methods, the 3D-printing technique is obviously the most efficient way to ...
- DOI:
- 10.1021/acsami.6b14297
- https://doi.org/10.1021/acsami.6b14297
- Author:
- Zewen Qiao; Wenping Zhang; Haifeng Jiang; Xiang Li; Weijun An; Haibo Yang
- Source:
- RSC advances 2022 v.12 no.18 pp. 11008-11020
- ISSN:
- 2046-2069
- Subject:
- Neottia; absorption; adhesion; antibacterial properties; bone formation; bone marrow; histology; humans; mechanics; microparticles; orthopedics; rabbits; therapeutics
- Abstract:
- ... In the field of orthopedics, an infected bone defect is a refractory disease accompanied by bone infection and defects as well as aggravated circulation. There are currently no personalized scaffolds that can treat bone infections using local stable and sustained-release antibiotics while providing mechanical support and bone induction to promote bone repair in the process of absorption in vivo. I ...
- DOI:
- 10.1039/d2ra00214k
- https://doi.org/10.1039/d2ra00214k
- Author:
- Jiawei Wei; Yan Yan; Jing Gao; Yubao Li; Ruili Wang; Jiexin Wang; Qin Zou; Yi Zuo; Meifang Zhu; Jidong Li
- Source:
- Biomaterials advances 2022 v.133 pp. 112618
- ISSN:
- 2772-9508
- Subject:
- biocompatible materials; bone formation; bone marrow; cell adhesion; cell culture; compression strength; hydroxyapatite; microparticles; polyvinyl alcohol; strength (mechanics)
- Abstract:
- ... Bone tissue engineering scaffolds with similar composition, structure, and mechanical properties to natural bone are conducive to bone regeneration. The objective of this study was to prepare hydroxyapatite/poly (lactic-co-glycolic acid) (HA/PLGA) three-dimensional porous scaffolds with HA content close to natural bone and strong mechanical strength to promote osteogenesis. To achieve this, we mod ...
- DOI:
- 10.1016/j.msec.2021.112618
- https://doi.org/10.1016/j.msec.2021.112618
- Author:
- Peng Zhang; Fulin Tao; Qinghu Li; Shuai Wu; Baisheng Fu; Ping Liu
- Source:
- Journal of biosciences 2019 v.44 no.4 pp. 87
- ISSN:
- 0250-5991
- Subject:
- alkaline phosphatase; animal models; apoptosis; beta catenin; bone formation; bone marrow; caspase-3; caspase-9; cell proliferation; femur; gene expression; gene expression regulation; interphase; mesenchymal stromal cells; messenger RNA; necrosis; osteocalcin; rabbits; signal transduction; transcription factors
- Abstract:
- ... Bone marrow mesenchymal stem cells (BMSCs) play an important role in the process of bone repair. The present study investigated the effect of 5-azacytidine (AZA) and trichostatin A (TSA) on BMSC behaviors in vitro. The role of WNT family member 5A (WNT5A)/WNT family member 5A (WNT7A)/β-catenin signaling was also investigated. BMSCs were isolated from a steroid-induced avascular necrosis of the fem ...
- DOI:
- 10.1007/s12038-019-9901-7
- https://doi.org/10.1007/s12038-019-9901-7
- Author:
- Eun‐Nam Kim; Yu Gyeong Kim; Jeong‐Hyung Lee; Byung Sun Min; Gil‐Saeng Jeong
- Source:
- Phytotherapy research 2019 v.33 no.11 pp. 2948-2959
- ISSN:
- 0951-418X
- Subject:
- Dalbergia odorifera; T-lymphocytes; actin; animal models; bone marrow; bone resorption; cathepsin K; cytoplasm; heartwood; humans; ligands; lipopolysaccharides; macrophages; mice; mitogen-activated protein kinase; monocytes; osteoblasts; osteoclasts; signal transduction; skeleton; transcription factor NF-kappa B
- Abstract:
- ... The balance between the osteoblasts and the osteoclasts is important for the maintenance of the skeleton of the human body. The osteoclasts absorb bone after differentiated into polymorphonuclear cells by the fusion of monocytes/macrophages. We have found that 6,7,4′‐Trihydroxyflavone (THF), a compound from the heartwood of Dalbergia Odorifera inhibits receptor activator of NF‐κB ligand (RANKL)‐in ...
- DOI:
- 10.1002/ptr.6468
- https://doi.org/10.1002/ptr.6468
- Author:
- Shu-Chieh Hu; Seonggi Min; Hyun-Ki Kang; Dong-Jin Yang; Mallikarjuna Basavarajappa; Sherry M. Lewis; Kelly J. Davis; Ralph E. Patton; Matthew S. Bryant; Estatira Sepehr; Raul Trbojevich; Mason G. Pearce; Michelle E. Bishop; Wei Ding; Robert H. Heflich; MacKean P. Maisha; Robert Felton; Susan Chemerynski; Steven B. Yee; Melis Coraggio; Hans Rosenfeldt; R. Philip Yeager; Paul C. Howard; Yunan Tang
- Source:
- Food and chemical toxicology 2022 v.160 pp. 112780
- ISSN:
- 0278-6915
- Subject:
- DNA; aerosols; air; biomarkers; blood; body weight; bone marrow; breathing; carcinogenesis; carcinogenicity; cigarettes; comet assay; food consumption; genotoxicity; histopathology; humans; inhalation toxicity; lowest observed effect level; lungs; metabolites; mutagens; nitrosamines; no observed adverse effect level; nose; propylene glycol; urine
- Abstract:
- ... 4-(Methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) is one of the key tobacco-specific nitrosamines that plays an important role in human lung carcinogenesis. Repeated dose inhalation toxicity data on NNK, particularly relevant to cigarette smoking, however, is surprisingly limited. Hence, there is a lack of direct information available on the carcinogenic and potential non-carcinogenic effects o ...
- DOI:
- 10.1016/j.fct.2021.112780
- https://doi.org/10.1016/j.fct.2021.112780
- Author:
- Yang, Dan; Koupenova, Milka; McCrann, Donald J.; Kopeikina, Katherine J.; Kagan, Herbert M.; Schreiber, Barbara M.; Ravid, Katya
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.2 pp. 792-796
- ISSN:
- 0027-8424
- Subject:
- CXCR4 receptor; bone marrow; bone marrow cells; bone marrow transplant; humans; macrophages; mice; models; myocytes; purinergic receptors; smooth muscle; stem cells; tissue repair; tumor necrosis factor-alpha
- Abstract:
- ... The A2b adenosine receptor (A2bAR) is highly abundant in bone marrow macrophages and vascular smooth muscle cells (VSMC). To examine the functional significance of this receptor expression, we applied a femoral artery injury model to A2bAR knockout (KO) mice and showed that the A2bAR prevents vascular lesion formation in an injury model that resembles human restenosis after angioplasty. While cons ...
- DOI:
- 10.1073/pnas.0705563105
- PubMed:
- 18184815
- PubMed Central:
- PMC2206615
- https://doi.org/10.1073/pnas.0705563105
- Author:
- Robert J. Griffin; Gal Shafirstein; Jessica Webber; Nathan A. Koonce; Beata Przybyla
- Source:
- Cryobiology 2014 v.69 no.1 pp. 192-193
- ISSN:
- 0011-2240
- Subject:
- adjuvants; blood flow; blood vessels; bone marrow; breast neoplasms; cold; cryosurgery; cytotoxicity; drugs; hypoxia; ionizing radiation; mice; nanomedicine; radiotherapy; research programs; stem cells; sterilizing; temperature; Arkansas
- Abstract:
- ... The physiological reaction of tumor tissue and the progression of normal vascular and cellular repair processes in the body after thermal ablation suggest specific ways that adjuvant therapies may improve tumor control. This is a topic of growing importance as thermal ablation techniques are being used more than ever yet continue to have significant and unpredictable recurrence rates in clinical s ...
- DOI:
- 10.1016/j.cryobiol.2014.06.043
- https://doi.org/10.1016/j.cryobiol.2014.06.043
- Author:
- Wenxing Gu; Tianhui Liu; Daoyang Fan; Jubin Zhang; Yifeng Xia; Fenghua Meng; Yang Xu; Jeroen J.L.M. Cornelissen; Zhongjun Liu; Zhiyuan Zhong
- Source:
- Journal of controlled release 2021 v.329 pp. 706-716
- ISSN:
- 0168-3659
- Subject:
- adverse effects; blood; bone marrow; drug therapy; liver; mice; myeloid leukemia; neoplasm cells; relapse; spleen; vincristine
- Abstract:
- ... Acute myeloid leukemia (AML) is a severe blood malignancy associated with a high relapse rate. The current clinical chemotherapy is typically perplexed with serious side effects. Here, A6 peptide-tagged, small and reduction-sensitive polymersomal vincristine sulfate (A6-cPS-VCR) is reported as a novel, smart and specific treatment for CD44 positive AML. A6-cPS-VCR stably loaded with 3.3 wt% VCR di ...
- DOI:
- 10.1016/j.jconrel.2020.10.005
- https://doi.org/10.1016/j.jconrel.2020.10.005
- Author:
- Wolf-Stephan Rudi; Michael Molitor; Venkata Garlapati; Stefanie Finger; Johannes Wild; Thomas Münzel; Susanne H. Karbach; Philip Wenzel
- Source:
- Antioxidants 2021 v.10 no.3 pp. -
- ISSN:
- 2076-3921
- Subject:
- bone marrow; drug therapy; heart failure; hematopoiesis; inflammation; macrophages; mice; monocytes; myocardial infarction
- Abstract:
- ... Aims: Angiotensin-converting-enzyme inhibitors (ACE inhibitors) are a cornerstone of drug therapy after myocardial infarction (MI) and improve left ventricular function and survival. We aimed to elucidate the impact of early treatment with the ACE inhibitor ramipril on the hematopoietic response after MI, as well as on the chronic systemic and vascular inflammation. Methods and Results: In a mouse ...
- DOI:
- 10.3390/antiox10030396
- https://doi.org/10.3390/antiox10030396
- Author:
- Jodi F. Evans; Sylvana Rodriguez; Louis Ragolia
- Source:
- Cell and tissue research 2013 v.352 no.2 pp. 413-425
- ISSN:
- 0302-766X
- Subject:
- agonists; alkaline phosphatase; alpha-melanocyte-stimulating hormone; bone formation; bone marrow; calcium; cell culture; chondrogenesis; collagen; corticotropin; dexamethasone; messenger RNA; peptide hormones; physiological transport; rats; receptors; stromal cells
- Abstract:
- ... Adrenocorticotropic hormone (ACTH) is among several melanocortin peptide hormones that are derived from proopiomelanocortin (POMC). ACTH has been found to enhance osteogenesis and chondrogenesis. We show that, in the presence of dexamethasone, ACTH dose-dependently increases chondrogenic nodule formation in bone marrow stromal cells (BMSC) from the Wistar Kyoto (WKY) rat. The nodules consist in co ...
- DOI:
- 10.1007/s00441-013-1561-6
- PubMed:
- 23358747
- PubMed Central:
- PMC3640708
- https://doi.org/10.1007/s00441-013-1561-6
- Author:
- Shibing Yu; Rohit Sharma; Daibang Nie; Hongli Jiao; Hee-Jeong Im; Yumei Lai; Zhongfang Zhao; Ke Zhu; Jie Fan; Di Chen; Qingde Wang; Guozhi Xiao
- Source:
- Gene 2013 v.513 pp. 101-110
- ISSN:
- 0378-1119
- Subject:
- RNA; RNA editing; adenosine deaminase; alkaline phosphatase; bone density; bone formation; bone marrow; bone resorption; cell growth; genes; mice; mineralization; osteoblasts; osteocalcin; phenotype; stem cells; stromal cells
- Abstract:
- ... Bone mass is controlled through a delicate balance between osteoblast-mediated bone formation and osteoclast-mediated bone resorption. We show here that RNA editing enzyme adenosine deaminase acting on RNA 1 (ADAR1) is critical for proper control of bone mass. Postnatal conditional knockout of Adar1 (the gene encoding ADAR1) resulted in a severe osteopenic phenotype. Ablation of the Adar1 gene sig ...
- DOI:
- 10.1016/j.gene.2012.10.068
- PubMed:
- 23123729
- PubMed Central:
- PMC3514579
- https://doi.org/10.1016/j.gene.2012.10.068
- Author:
- XuFeng, Richard; Boyer, Matthew J.; Shen, Hongmei; Li, Yanxin; Yu, Hui; Gao, Yindai; Yang, Qiong; Wang, Qingde; Cheng, Tao
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.42 pp. 17763-17768
- ISSN:
- 0027-8424
- Subject:
- RNA; RNA editing; adenosine; adenosine deaminase; adults; apoptosis; bone marrow; cell viability; embryogenesis; hematopoiesis; hematopoietic stem cells; mice
- Abstract:
- ... Adenosine Deaminase Acting on RNA 1 (ADAR1) is an RNA-editing enzyme that converts adenosine to inosine, following RNA transcription. ADAR1's essential role in embryonic development, especially within the hematopoietic lineage, has been demonstrated in knock-out mice. However, a specific role for ADAR1 in adult hematopoietic progenitor cells (HPCs) remains elusive. In this report, we show that ADA ...
- DOI:
- 10.1073/pnas.0903324106
- PubMed:
- 19805087
- PubMed Central:
- PMC2764897
- https://doi.org/10.1073/pnas.0903324106
52. AGE-related differences in the hematological profile of Andalusian broodmares of Carthusian strain
- Author:
- K. Satue; O. Blanco; A. Munoz
- Source:
- Veterinární medicína v.54 no.4 pp. 175-182
- ISSN:
- 0375-8427
- Subject:
- bone marrow; eosinophils; hematocrit; hemoglobin; mares; monocytes; neutrophils; pregnancy
- Abstract:
- ... Normal hematological values need to be defined for each equine breed and age in order to increase diagnostic precision. No published data on hematology exist for Carthusian horses. This research compares the hematological characteristics of pregnant Carthusian broodmares of different ages. Forty-four pregnant Carthusian broodmares were divided into three age Groups: A (4–7 years; n = 18), B ...
- DOI:
- 10.17221/32/2009-vetmed
- https://doi.org/10.17221/32/2009-vetmed
- Author:
- Lindh, Emma; Lind, Sara M.; Lindmark, Evelina; Hässler, Signe; Perheentupa, Jaakko; Peltonen, Leena; Winqvist, Ola; Karlsson, Mikael C.I.
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2008 v.105 no.47 pp. 18466-18471
- ISSN:
- 0027-8424
- Subject:
- B-lymphocytes; T-lymphocytes; antigens; autoantibodies; blood serum; bone marrow; dendritic cells; in vitro studies; interferon-gamma; interleukin-10; liver; lymphoma; mice; mutation; patients; phenotype; regulator genes; splenomegaly; tumor necrosis factors
- Abstract:
- ... Autoimmune polyendocrine syndrome type I (APS I) results in multiple endocrine organ destruction and is caused by mutations in the autoimmune regulator gene (AIRE). APS I is characterized by circulating tissue-specific autoantibodies, and the presence of these antibodies is often predictive of organ destruction. The importance of AIRE in ensuring central tolerance by regulating the negative select ...
- DOI:
- 10.1073/pnas.0808205105
- PubMed:
- 19011083
- PubMed Central:
- PMC2587634
- https://doi.org/10.1073/pnas.0808205105
- Author:
- Bas Brinkhof; Bo Zhang; Zhanfeng Cui; Hua Ye; Hui Wang
- Source:
- Gene: X 2020 v.763 pp. 100031
- ISSN:
- 0378-1119
- Subject:
- RNA; biomarkers; biopsy; bone marrow; byproducts; cell adhesion molecules; fibroblasts; gene expression; gene therapy; genes; humans; mesenchymal stromal cells; oxygen; quantitative polymerase chain reaction; rapid methods; umbilical cord
- Abstract:
- ... Human mesenchymal stromal cells (MSCs) phenotypically share their positive expression of the International Society for Cell and Gene Therapy (ISCT) markers CD73, CD90 and CD105 with fibroblasts. Fibroblasts are often co-isolated as an unwanted by-product from biopsy and they can rapidly overgrow the MSCs in culture. Indeed, many other surface markers have been proposed, though no unique MSC specif ...
- DOI:
- 10.1016/j.gene.2020.100031
- https://doi.org/10.1016/j.gene.2020.100031
- Author:
- Cui Zhang; Shali Wu; Erman Chen; Luyang Yu; Jinfu Wang; Mengrui Wu
- Source:
- Cellular and molecular life sciences 2022 v.79 no.6 pp. 328
- ISSN:
- 1420-682X
- Subject:
- biogenesis; bone formation; bone marrow; gain-of-function mutation; gene expression regulation; insulin; loss-of-function mutation; mice; models; osteoblasts; ribonucleoproteins; therapeutics; tibia; transcription (genetics); transcription factors
- Abstract:
- ... The osteogenic potential of bone marrow mesenchymal stem cells (BMSCs) is critical for bone formation and regeneration. A high non-/delayed-union rate of fracture healing still occurs in specific populations, implying an urgent need to discover novel targets for promoting osteogenesis and bone regeneration. Long non-coding (lnc)RNAs are emerging regulators of multiple physiological processes, incl ...
- DOI:
- 10.1007/s00018-022-04338-7
- https://doi.org/10.1007/s00018-022-04338-7
- Author:
- Xuan Liu; Wenqing Hou; Lei He; Fangping Han; Mengjie Lu; Xiaobo Lu; Ke Duan; Tailin Guo; Jie Weng
- Source:
- Colloids and surfaces 2019 v.182 pp. 110332
- ISSN:
- 0927-7765
- Subject:
- actin; biocompatible materials; bone marrow; cell differentiation; gene expression; nanotubes; osteoblasts; physiological transport; rats; stems; titanium; titanium dioxide; translation (genetics)
- Abstract:
- ... Micro/nano-topography (MNT) is an important variable affecting osseointegration of bone biomaterials, but the underlying mechanisms are not fully understood. We probed the role of a AMOT130/YAP pathway in osteoblastic differentiation of bone marrow mesenchymal stems cultured on titanium (Ti) carrying MNTs. Ti surfaces with two well-defined MNTs (TiO2 nanotubes of different diameters and wall thick ...
- DOI:
- 10.1016/j.colsurfb.2019.06.061
- https://doi.org/10.1016/j.colsurfb.2019.06.061
- Author:
- Shigeki Hirabayashi; Kotaro Shirakawa; Yoshihito Horisawa; Tadahiko Matsumoto; Hiroyuki Matsui; Hiroyuki Yamazaki; Anamaria Daniela Sarca; Yasuhiro Kazuma; Ryosuke Nomura; Yoshinobu Konishi; Suguru Takeuchi; Emani Stanford; Hideya Kawaji; Yasuhiro Murakawa; Akifumi Takaori-Kondo
- Source:
- Biochemical and biophysical research communications 2021 v.546 pp. 178-184
- ISSN:
- 0006-291X
- Subject:
- bone marrow; carcinogenesis; cytosine; cytosine deaminase; myeloma; research; sequence analysis; single-stranded DNA; uracil
- Abstract:
- ... APOBEC3B (A3B) is a cytosine deaminase that converts cytosine to uracil in single-stranded DNA. Cytosine-to-thymine and cytosine-to-guanine base substitution mutations in trinucleotide motifs (APOBEC mutational signatures) were found in various cancers including lymphoid hematological malignancies such as multiple myeloma and A3B has been shown to be an enzymatic source of mutations in those cance ...
- DOI:
- 10.1016/j.bbrc.2021.02.008
- https://doi.org/10.1016/j.bbrc.2021.02.008
- Author:
- Shintaro Watanuki; Hiroshi Kobayashi; Yuriko Sorimachi; Masamichi Yamamoto; Shinichiro Okamoto; Keiyo Takubo
- Source:
- Biochemical and biophysical research communications 2019 v.514 no.1 pp. 287-294
- ISSN:
- 0006-291X
- Subject:
- adenosine triphosphate; bone marrow; cell cycle; cell differentiation; glucose; glycolysis; hematopoietic stem cells; monitoring; monocytes; nutrient requirements; oxidative phosphorylation
- Abstract:
- ... Hematopoietic stem cells (HSCs) are quiescent cells in the bone marrow niche and are relatively dependent on glycolytic ATP production. On the other hand, differentiated cells, including hematopoietic progenitor cells (HPCs), preferentially generate ATP via oxidative phosphorylation. However, it is unclear how cellular differentiation and the cell cycle status affect nutritional requirements and A ...
- DOI:
- 10.1016/j.bbrc.2019.04.123
- https://doi.org/10.1016/j.bbrc.2019.04.123
- Author:
- Yvan-Charvet, Laurent; Pagler, Tamara; Gautier, Emmanuel L.; Avagyan, Serine; Siry, Read L.; Han, Seongah; Welch, Carrie L.; Wang, Nan; Randolph, Gwendalyn J.; Snoeck, Hans W.; Tall, Alan R.
- Source:
- Science 2010 v.328 no.5986 pp. 1689-1693
- ISSN:
- 0036-8075
- Subject:
- ABC transporters; adenosine; apolipoprotein A-I; atherosclerosis; bone marrow; cell proliferation; cholesterol; hematopoietic stem cells; high density lipoprotein; hypercholesterolemia; macrophages; mice; monocytes; transgenic animals
- Abstract:
- ... Elevated leukocyte cell numbers (leukocytosis), and monocytes in particular, promote atherosclerosis; however, how they become increased is poorly understood. Mice deficient in the adenosine triphosphate-binding cassette (ABC) transporters ABCA1 and ABCG1, which promote cholesterol efflux from macrophages and suppress atherosclerosis in hypercholesterolemic mice, displayed leukocytosis, a transpla ...
- DOI:
- 10.1126/science.1189731
- PubMed:
- 20488992
- PubMed Central:
- PMC3032591
- https://doi.org/10.1126/science.1189731
- Author:
- Lei Zhou; Shiwei Sun; Tieqi Zhang; Yueming Yu; Liang Xu; Haoran Li; Minghai Wang; Yang Hong
- Source:
- Molecular biology reports 2020 v.47 no.10 pp. 7439-7449
- ISSN:
- 0301-4851
- Subject:
- adipogenesis; alkaline phosphatase; bone formation; bone marrow; cholesterol; gene expression regulation; genes; molecular biology; osteoblasts; osteoporosis; therapeutics; transcription factors
- Abstract:
- ... The dysfunction of bone marrow mesenchymal stem cells (BMSCs) in balancing osteogenesis and adipogenesis plays an important role in the occurrence and development of osteoporosis. It’s still unknown that whether ATP-binding cassette g1 (Abcg1), a well-proved regulation gene of adipogenesis, regulates osteogenesis. In our previous study, we identified 30 differentially expressed genes in osteogenes ...
- DOI:
- 10.1007/s11033-020-05800-0
- https://doi.org/10.1007/s11033-020-05800-0
- Author:
- Lin Li; Shaoqing Yang; Yanli Zhang; Dongrui Ji; Zuolin Jin; Xiaohong Duan
- Source:
- Biochemical and biophysical research communications 2018 v.502 no.1 pp. 84-90
- ISSN:
- 0006-291X
- Subject:
- Danio rerio; H-transporting ATP synthase; bone formation; bone marrow; bone resorption; cell cycle checkpoints; gene expression; histology; humans; messenger RNA; mice; stromal cells; transforming growth factor beta 1; transforming growth factor beta receptors
- Abstract:
- ... ATP6V1H encodes subunit H of vacuolar ATPase (V-ATPase) and may regulate osteoclastic function. The deficiency of ATP6V1H caused bone loss in human, mouse and zebrafish. In this report, we identified the mechanisms by which ATP6V1H regulates proliferation and differentiation of bone marrow stromal cells (BMSCs). We found that ATP6V1H was expressed in BMSCs, and Atp6v1h+/- BMSCs exhibited the lower ...
- DOI:
- 10.1016/j.bbrc.2018.05.124
- https://doi.org/10.1016/j.bbrc.2018.05.124
- Author:
- Mi, Shuangli; Li, Zejuan; Chen, Ping; He, Chunjiang; Cao, Donglin; Elkahloun, Abdel; Lu, Jun; Pelloso, Luis A.; Wunderlich, Mark; Huang, Hao; Luo, Roger T.; Sun, Miao; He, Miao; Neilly, Mary Beth; Zeleznik-Le, Nancy J.; Thirman, Michael J.; Mulloy, James C.; Liu, Paul P.; Rowley, Janet D.; Chen, Jianjun
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.8 pp. 3710-3715
- ISSN:
- 0027-8424
- Subject:
- DNA; acetylation; apoptosis; bone marrow; cell cycle; cell differentiation; cell proliferation; gene expression regulation; gene fusion; gene overexpression; genes; hematopoiesis; histones; humans; leukemia; loci; lymphoma; messenger RNA; mice; microRNA; stem cells
- Abstract:
- ... MicroRNA (miRNA)-17-92 cluster (miR-17-92), containing seven individual miRNAs, is frequently amplified and overexpressed in lymphomas and various solid tumors. We have found that it is also frequently amplified and the miRNAs are aberrantly overexpressed in mixed lineage leukemia (MLL)-rearranged acute leukemias. Furthermore, we show that MLL fusions exhibit a much stronger direct binding to the ...
- DOI:
- 10.1073/pnas.0914900107
- PubMed:
- 20133587
- PubMed Central:
- PMC2840429
- https://doi.org/10.1073/pnas.0914900107
- Author:
- E. A. Tarakhtii; R. I. Ishmetova
- Source:
- Biology bulletin of the Russian Academy of Sciences 2021 v.48 no.3 pp. 340-350
- ISSN:
- 1062-3590
- Subject:
- acute toxicity; bone marrow; cesium radioisotopes; lethal dose; mice; oxygen consumption
- Abstract:
- ... A complex of parameters of the blood system of BALB/c mice was studied using alkanes symmetrically and asymmetrically replaced with heterocyclic amines, which protected 85–100% of mice after total exposure to ¹³⁷Cs γ-radiation at the minimum lethal dose. The ability of substances of different structures to protect hematopoietic tissue in in vivo and in vitro experiments has been established. Diffe ...
- DOI:
- 10.1134/S1062359021030158
- https://doi.org/10.1134/S1062359021030158
- Author:
- Mylonakis, M.E.; Day, M.J.; Siarkou, V.; Vernau, W.; Koutinas, A.F.
- Source:
- Journal of comparative pathology 2010 v.142 no.4 pp. 328-331
- ISSN:
- 0021-9975
- Subject:
- dogs; Ehrlichia canis; dog diseases; ehrlichiosis; histopathology; bone marrow; signs and symptoms (animals and humans); cell differentiation
- DOI:
- 10.1016/j.jcpa.2009.09.003
- PubMed:
- 19906384
- https://doi.org/10.1016/j.jcpa.2009.09.003
- Author:
- Julieta Panero; Nathan J. O’Callaghan; Michael Fenech; Irma Slavutsky
- Source:
- Molecular biotechnology 2015 v.57 no.2 pp. 155-159
- ISSN:
- 1073-6085
- Subject:
- DNA; biomarkers; bone marrow; pathogenesis; patients; prognosis; quantitative polymerase chain reaction; telomeres
- Abstract:
- ... Telomere length (TL) is currently used as an emerging biomarker in understanding the development/progression of hematological malignancies. The absolute quantitative PCR (qPCR) methodology has allowed the study of TL from a variety of mammalian tissues, but it has not been tested for bone marrow (BM) samples. In this study, we have examined the relationship between TL data generated by absolute qP ...
- DOI:
- 10.1007/s12033-014-9811-8
- PubMed:
- 25311116
- https://doi.org/10.1007/s12033-014-9811-8
- Author:
- Akihiro Tamura; Hideyo Hirai; Asumi Yokota; Atsushi Sato; Tsukimi Shoji; Takahiro Kashiwagi; Masaki Iwasa; Aya Fujishiro; Yasuo Miura; Taira Maekawa
- Source:
- Biochemical and biophysical research communications 2015 v.464 pp. 654-658
- ISSN:
- 0006-291X
- Subject:
- apoptosis; bone marrow; bone marrow cells; flow cytometry; hematopoiesis; macrophages; mice; monocytes; transcription factors
- Abstract:
- ... The CCAAT/enhancer-binding protein β (C/EBPβ) transcription factor is required for granulopoiesis under stress conditions. However, little is known about its roles in steady state hematopoiesis. Here, we analyzed the peripheral blood and bone marrow of Cebpb−/− mice at steady state by flow cytometry and unexpectedly found that the number of peripheral blood monocytes was severely reduced, while th ...
- DOI:
- 10.1016/j.bbrc.2015.07.045
- https://doi.org/10.1016/j.bbrc.2015.07.045
- Author:
- James P. Long; Mark S. Kotur; Gregory V. Stark; Richard L. Warren; Manjula Kasoji; Jeremy L. Craft; Randy A. Albrecht; Adolfo García-Sastre; Michael G. Katze; Katrina M. Waters; Daphne Vasconcelos; Patrick J. Sabourin; Herbert S. Bresler; Carol L. Sabourin
- Source:
- Archives of virology 2013 v.158 no.6 pp. 1305-1322
- ISSN:
- 0304-8608
- Subject:
- Influenza A virus; T-lymphocytes; apoptosis; arginase; arginine; bone marrow; chemokines; gene expression regulation; genes; glycoproteins; hosts; humans; immunity; lungs; metabolism; mice; proline; reactive oxygen species; sialidase; virulence; viruses
- Abstract:
- ... Infection with pathogenic influenza viruses is associated with intense inflammatory disease. Here, we investigated the innate immune response in mice infected with H5N1 A/Vietnam/1203/04 and with reassortant human H1N1 A/Texas/36/91 viruses containing the virulence genes hemagglutinin (HA), neuraminidase (NA) and NS1 of the 1918 pandemic virus. Inclusion of the 1918 HA and NA glycoproteins rendere ...
- DOI:
- 10.1007/s00705-012-1593-3
- PubMed:
- 23397329
- PubMed Central:
- PMC5533288
- https://doi.org/10.1007/s00705-012-1593-3
- Author:
- Katarzyna Tajchman; Aleksandra Ukalska-Jaruga; Marek Bogdaszewski; Monika Pecio; Katarzyna Dziki-Michalska
- Source:
- Animals 2020 v.10 no.11 pp. -
- ISSN:
- 2076-2615
- Subject:
- Cervus elaphus; aluminum; arsenic; atomic absorption spectrometry; barium; bone marrow; cadmium; case studies; lead; nickel; toxicity; vanadium
- Abstract:
- ... The aim of the study was to determine the concentrations of toxic elements accumulated in the bone marrow and bones (Cervus elaphus). The studies were carried out on two groups of young stags: farmed (n = 6) and wild (n = 9). Their body weights were measured and bone and bone marrow samples were collected. The concentrations of toxic elements were analyzed using the inductively coupled plasma mass ...
- DOI:
- 10.3390/ani10112151
- https://doi.org/10.3390/ani10112151
- Author:
- Pedro L. Sánchez; M. Eugenia Fernández-Santos; Salvatore Costanza; Andreu M. Climent; Isabel Moscoso; M. Angeles Gonzalez-Nicolas; Ricardo Sanz-Ruiz; Hugo Rodríguez; Stefan M. Kren; Gregorio Garrido; Jose L. Escalante; Javier Bermejo; Jaime Elizaga; Javier Menarguez; Raquel Yotti; Candelas Pérez del Villar; M. Angeles Espinosa; María S. Guillem; James T. Willerson; Antonio Bernad; Rafael Matesanz; Doris A. Taylor; Francisco Fernández-Avilés
- Source:
- Biomaterials 2015 v.61 pp. 279-289
- ISSN:
- 0142-9612
- Subject:
- bone marrow; calcium; cardiomyocytes; cell viability; endothelial cells; extracellular matrix; gene expression; genes; heart failure; humans; manufacturing; microstructure; muscles; sodium dodecyl sulfate; stem cells
- Abstract:
- ... The best definitive treatment option for end-stage heart failure currently is transplantation, which is limited by donor availability and immunorejection. Generating an autologous bioartificial heart could overcome these limitations. Here, we have decellularized a human heart, preserving its 3-dimensional architecture and vascularity, and recellularized the decellularized extracellular matrix (dEC ...
- DOI:
- 10.1016/j.biomaterials.2015.04.056
- https://doi.org/10.1016/j.biomaterials.2015.04.056
- Author:
- Xilinqiqige Bao; Takuya Ogawa; Satoru Se; Motofusa Akiyama; Anton Bahtiar; Tatsuo Takeya; Norihiro Ishida-Kitagawa
- Source:
- Biochemical and biophysical research communications 2011 v.405 no.4 pp. 533-537
- ISSN:
- 0006-291X
- Subject:
- bone marrow; genes; macrophages; osteoclasts; phosphotransferases (kinases); sphingosine
- Abstract:
- ... Acid sphingomyelinase (ASM) was identified as a gene induced by NFAT2 activation in osteoclasts. Suppression of ASM expression in bone marrow macrophages by knockdown enhanced c-Fos/NFAT2 expression, increasing the number of TRAP-positive multinucleated cells in vitro. SphK1 was upregulated during the late stage of osteoclastogenesis, while SphK2 expression remained constant. SphK1 was downregulat ...
- DOI:
- 10.1016/j.bbrc.2011.01.061
- https://doi.org/10.1016/j.bbrc.2011.01.061
- Author:
- Ben Mansour, Hédi; Ayed-Ajmi, Yosra; Mosrati, Ridha; Corroler, David; Ghedira, Kamel; Barillier, Daniel; Chekir-Ghedira, Leila
- Source:
- Environmental science and pollution research international 2010 v.17 no.7 pp. 1371-1378
- ISSN:
- 0944-1344
- Subject:
- Pseudomonas putida; acetylcholinesterase; azo dyes; biodegradation; bone marrow; cholinesterase; chromosome aberrations; lipid peroxidation; metabolism; metabolites; mice; paper; textile industry; toxicity
- Abstract:
- ... Introduction Acid violet 7 (AV7), mostly used in food, paper, cosmetic, and especially in textile industries, was degraded by Pseudomonas putida mt-2 at concentrations up to 200 mg/l. Materials and methods In this study, toxicity of AV7, before and after biodegradation, was evaluated in vivo, in mouse bone marrow, by assessing the percentage of cells bearing different chromosome aberrations, membr ...
- DOI:
- 10.1007/s11356-010-0323-1
- PubMed:
- 20369386
- https://doi.org/10.1007/s11356-010-0323-1
- Author:
- Saeed Mohammadi; Seyed H. Ghaffari; Mojgan Shaiegan; Mahin Nikougoftar Zarif; Mohsen Nikbakht; Shiva Akbari Birgani; Kamran Alimoghadam; Ardeshir Ghavamzadeh
- Source:
- Life sciences 2016 v.152 pp. 190-198
- ISSN:
- 0024-3205
- Subject:
- beta catenin; bone marrow; cell lines; cell viability; curcumin; drug resistance; flow cytometry; myeloid leukemia; osteopontin; patients; quantitative polymerase chain reaction; reverse transcriptase polymerase chain reaction; signal transduction; small interfering RNA; stem cells; therapeutics; transcription factor NF-kappa B
- Abstract:
- ... Acute myeloid leukemia (AML) initiation and progression have been attributed to subpopulations of self-renewing leukemia stem cells (LSCs), which contribute to progression, recurrence and therapeutic resistance in leukemia. Osteopontin (OPN) plays an important role in promoting survival and drug resistance in LSCs. The aim of this study was to explore OPN roles in modulating curcumin-mediated LSC ...
- DOI:
- 10.1016/j.lfs.2016.04.003
- https://doi.org/10.1016/j.lfs.2016.04.003
- Author:
- Dominika Grzybowska; Anna Snarska
- Source:
- Journal of Veterinary Research 2021 v.65 no.3 pp. 323-327
- ISSN:
- 2450-8608
- Subject:
- Danish Landrace; acrylamides; anticoagulants; bone marrow; cell structures; eosinophils; gelatin; light microscopes; neutrophils; placebos; swine; toxicity; veterinary medicine
- Abstract:
- ... Due to the widely documented and diverse toxic effects of acrylamide, the authors decided to evaluate the impact of high and low doses of this compound on the process of granulopoiesis in porcine bone marrow. The experiment was conducted on 15 Danish Landrace pigs at the age of 8 weeks. The animals were randomly assigned into three equal groups (n = 5). Control animals received empty gelatine caps ...
- DOI:
- 10.2478/jvetres-2021-0040
- https://doi.org/10.2478/jvetres-2021-0040
- Author:
- Margaret K. Seeley-Fallen; Lisa J. Liu; Melanie R. Shapiro; Olusegun O. Onabajo; Senthilkumar Palaniyandi; Xiaoping Zhu; Tse-Hua Tan; Arpita Upadhyaya; Wenxia Song
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2014 v.111 no.27 pp. 9881-9886
- ISSN:
- 0027-8424
- Subject:
- B-lymphocytes; actin; antigens; autoantibodies; autoimmunity; blood serum; bone marrow; calcium; chimerism; inositols; mice; mitogen-activated protein kinase; mitogen-activated protein kinase kinase; phosphorylation; receptors; signal transduction
- Abstract:
- ... Prolonged or uncontrolled B-cell receptor (BCR) signaling is associated with autoimmunity. We previously demonstrated a role for actin in BCR signal attenuation. This study reveals that actin-binding protein 1 (Abp1/HIP-55/SH3P7) is a negative regulator of BCR signaling and links actin to negative regulatory pathways of the BCR. In both Abp1 ⁻/⁻ and bone marrow chimeric mice, in which only B cells ...
- DOI:
- 10.1073/pnas.1321971111
- PubMed:
- 24958882
- PubMed Central:
- PMC4103327
- https://doi.org/10.1073/pnas.1321971111
- Author:
- Jong-Ho KOH; Kwang-Won YU; Hyung-Joo SUH; Yang-Moon CHOI; Tae-Seok AHN
- Source:
- Bioscience, biotechnology, and biochemistry 2002 v.66 no.2 pp. 407-411
- ISSN:
- 1347-6947
- Subject:
- Ophiocordyceps sinensis; Peyer's patches; arabinose; biotechnology; bone marrow; galactose; glucose; interleukin-6; intestines; lipids; macrophages; mannose; mycelium; oral administration; secretion
- Abstract:
- ... The effects of an orally administered hot-water extract (HW) from cultured mycelia of Cordyceps sinensis on the activation of macrophages and the intestinal immune system were studied in mice. The general composition of HW was 83.9% carbohydrate, 11.8% protein, 1.9% lipid and 2.4% ash, and the carbohydrates were mainly composed of glucose, mannose, galactose and arabinose (molar ratio of 1.0:0.8:0 ...
- DOI:
- 10.1271/bbb.66.407
- https://doi.org/10.1271/bbb.66.407
- Author:
- Xing Jin; Xu Zhang; Jinchun Li; Weiyi Yu; Fangfang Chen
- Source:
- American journal of veterinary research 2018 v.79 no.12 pp. 1306-1312
- ISSN:
- 0002-9645
- Subject:
- bone marrow; cell lines; cell nucleus; chickens; coculture; erythrocytes; genes; genetic markers; inducible nitric oxide synthase; interleukin-10; interleukin-12; lipopolysaccharides; macrophages; mice; quantitative polymerase chain reaction; transcription (genetics); transforming growth factor beta; tumor necrosis factor-alpha; veterinary medicine
- Abstract:
- ... OBJECTIVE To characterize activation and expression of immune genes of chicken macrophages after in vitro stimulation with lipopolysaccharide (LPS) and mouse erythrocytes. ANIMALS Five 15-day-old chickens and 2 BALB/c mice. PROCEDURES Macrophages were extracted from chicken bone marrow or peripheral blood and then stimulated with cytokines secreted from cell lines L929 and HD11. Stimulated chicken ...
- DOI:
- 10.2460/ajvr.79.12.1306
- https://doi.org/10.2460/ajvr.79.12.1306
77. Activation of innate and humoral immunity in the peripheral nervous system of ALS transgenic mice
- Author:
- Chiu, Isaac M.; Phatnani, Hemali; Kuligowski, Michael; Tapia, Juan C.; Carrasco, Monica A.; Zhang, Ming; Maniatis, Tom; Carroll, Michael C.
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2009 v.106 no.49 pp. 20960-20965
- ISSN:
- 0027-8424
- Subject:
- amyotrophic lateral sclerosis; animal models; antibodies; bone marrow; chimerism; complement; cytokines; disease course; flow cytometry; humoral immunity; macrophage activation; macrophages; mice; mutants; nerve tissue; neuroglia; peripheral nerves; phagocytosis; spinal cord; transgenic animals
- Abstract:
- ... During injury to the nervous system, innate immune cells mediate phagocytosis of debris, cytokine production, and axon regeneration. In the neuro-degenerative disease amyotrophic lateral sclerosis (ALS), innate immune cells in the CNS are activated. However, the role of innate immunity in the peripheral nervous system (PNS) has not been well defined. In this study, we characterized robust activati ...
- DOI:
- 10.1073/pnas.0911405106
- PubMed:
- 19933335
- PubMed Central:
- PMC2791631
- https://doi.org/10.1073/pnas.0911405106
- Author:
- Weimin Qiu; Li Chen; Moustapha Kassem
- Source:
- Biochemical and biophysical research communications 2011 v.413 no.1 pp. 98-104
- ISSN:
- 0006-291X
- Subject:
- DNA microarrays; adipocytes; bone marrow; gene expression regulation; humans; mitogen-activated protein kinase; mutation; signal transduction; stem cells
- Abstract:
- ... The canonical Wnt signaling pathway can determine human bone marrow stromal (mesenchymal) stem cell (hMSC) differentiation fate into osteoblast or adipocyte lineages. However, its downstream targets in MSC are not well characterized. Thus, using DNA microarrays, we compared global gene expression patterns induced by Wnt3a treatment in two hMSC lines: hMSC-LRP5ᵀ²⁵³ and hMSC-LRP5ᵀ²⁴⁴ cells carrying ...
- DOI:
- 10.1016/j.bbrc.2011.08.061
- https://doi.org/10.1016/j.bbrc.2011.08.061
- Author:
- Riko Kitazawa; Satomi Kinto-Shibahara; Ryuma Haraguchi; Yukihiro Kohara; Sohei Kitazawa
- Source:
- Biochemical and biophysical research communications 2019 v.515 no.2 pp. 268-274
- ISSN:
- 0006-291X
- Subject:
- DNA; antibodies; binding sites; bone marrow; cold; gene expression; genes; genetic vectors; ligands; macrophages; mice; mutagenesis; oligonucleotides; osteoclasts; promoter regions; protein binding; protein kinase C; small interfering RNA; transcription (genetics); transcription factor NF-kappa B; transcriptional activation
- Abstract:
- ... Receptor activator of NF-κB (RANK) expressed on osteoclasts and their precursors is a receptor for RANK ligand (RANKL). Signals transduced by RANKL-RANK interaction induce genes essential for the differentiation and function of osteoclasts. We have cloned a basic promoter region of the mouse RANK gene and have analyzed the transcription machinery by transcription factors such as PU.1 (−480), and M ...
- DOI:
- 10.1016/j.bbrc.2019.05.144
- https://doi.org/10.1016/j.bbrc.2019.05.144
- Author:
- Kuraoka, Masayuki; Holl, T. Matt; Liao, Dongmei; Womble, Mandy; Cain, Derek W.; Reynolds, Alexander E.; Kelsoe, Garnett
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2011 v.108 no.28 pp. 11560-11565
- ISSN:
- 0027-8424
- Subject:
- DNA repair; antibody affinity; apoptosis; autoantibodies; blood serum; bone marrow; cytidine deaminase; deamination; gene conversion; genes; humoral immunity; mice
- Abstract:
- ... The Aicda gene product, activation-induced cytidine deaminase (AID), initiates somatic hypermutation, class-switch recombination, and gene conversion of Ig genes by the deamination of deoxycytidine, followed by error-prone mismatch- or base-excision DNA repair. These processes are crucial for the generation of genetically diverse, high affinity antibody and robust humoral immunity, but exact signi ...
- DOI:
- 10.1073/pnas.1102571108
- PubMed:
- 21700885
- PubMed Central:
- PMC3136303
- https://doi.org/10.1073/pnas.1102571108
- Author:
- Vallet, Sonia; Mukherjee, Siddhartha; Vaghela, Nileshwari; Hideshima, Teru; Fulciniti, Mariateresa; Pozzi, Samantha; Santo, Loredana; Cirstea, Diana; Patel, Kishan; Sohani, Aliyah R.; Guimaraes, Alex; Xie, Wanling; Chauhan, Dharminder; Schoonmaker, Jesse A.; Attar, Eyal; Churchill, Michael; Weller, Edie; Munshi, Nikhil; Seehra, Jasbir S.; Weissleder, Ralph; Anderson, Kenneth C.; Scadden, David T.; Raje, Noopur
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2010 v.107 no.11 pp. 5124-5129
- ISSN:
- 0027-8424
- Subject:
- bone marrow; clinical trials; humans; mitogen-activated protein kinase; models; myeloma; osteoblasts; pathogenesis; patients; secretion; stromal cells; transforming growth factor beta
- Abstract:
- ... Understanding the pathogenesis of cancer-related bone disease is crucial to the discovery of new therapies. Here we identify activin A, a TGF-β family member, as a therapeutically amenable target exploited by multiple myeloma (MM) to alter its microenvironmental niche favoring osteolysis. Increased bone marrow plasma activin A levels were found in MM patients with osteolytic disease. MM cell engag ...
- DOI:
- 10.1073/pnas.0911929107
- PubMed:
- 20194748
- PubMed Central:
- PMC2841922
- https://doi.org/10.1073/pnas.0911929107
- Author:
- V. F. Mikhailov; D. V. Saleeva; L. M. Rozhdestvensky; L. V. Shulenina; N. F. Raeva; G. D. Zasukhina
- Source:
- Russian journal of genetics 2021 v.57 no.10 pp. 1140-1148
- ISSN:
- 1022-7954
- Subject:
- abdominal cavity; biomarkers; bone marrow; hybrids; irradiation; liver; lymphoma; non-coding RNA; oncogenes
- Abstract:
- ... The activity of genes and noncoding RNAs was studied in 183 hybrid mice (CBA × C57Bl) F₁ after a prolonged low-power irradiation (within 21 h at a dose 12.6 Gy with a dose rate 10 mGy/min). The analysis of the studied parameters was carried out in the bone marrow of mice in the eighth and tenth months after irradiation. After ten month, radiation-induced malignant lymphomas in the liver, abdominal ...
- DOI:
- 10.1134/S1022795421100070
- https://doi.org/10.1134/S1022795421100070
- Author:
- Xiao-wen Zhang; Wen-bin Hou; Feng-lan Pu; Xue-feng Wang; Yi-ran Wang; Ming Yang; Ke Cheng; Yuyi Wang; Nicola Robinson; Jian-ping Liu
- Source:
- Phytomedicine 2022 v.106 pp. 154430
- ISSN:
- 0944-7113
- Subject:
- acupuncture; anxiety; bone marrow; breasts; dysphagia; gastrointestinal system; menopause; meta-analysis; nausea; pain; peripheral nervous system diseases; quality of life; risk; sleep disorders
- Abstract:
- ... Acupuncture is commonly used for cancer-related conditions worldwide, and evidence is increasing year on year. There is a need to summarize the evidence of acupuncture for cancer-related conditions comprehensively and critically. To evaluate and summarize the systematic reviews (SRs) that assess the effects and safety of acupuncture for cancer-related conditions, and to inform clinical practice an ...
- DOI:
- 10.1016/j.phymed.2022.154430
- https://doi.org/10.1016/j.phymed.2022.154430
- Author:
- Bockstal Viki; Geurts Nathalie; Magez Stefan
- Source:
- Journal of parasitology research 2011 v.2011 pp. -
- ISSN:
- 2090-0031
- Subject:
- B-lymphocytes; Plasmodium chabaudi; antibodies; apoptosis; bone marrow; chemokine CXCL12; disease control; immune response; malaria; memory; mice; parasitemia; parasites; spleen
- Abstract:
- ... B cells and antibodies are essential for the protective immune response against a blood-stage Plasmodium infection. Although extensive research has focused on memory as well as plasma B-cell responses during infection, little is known about how malaria affects B-cell development and splenic maturation into marginal zone B (MZB) and follicular B (FoB) cells. In this study, we show that acute Plasmo ...
- DOI:
- 10.1155/2011/534697
- PubMed:
- 21687602
- PubMed Central:
- PMC3112522
- https://doi.org/10.1155/2011/534697
- Author:
- Carina J. Cooper; Stefan M. Keller; Luis G. Arroyo; Joanne Hewson; Daniel Kenney; Dorothee Bienzle
- Source:
- Veterinary pathology v.55 no.1 pp. 159-172
- ISSN:
- 1544-2217
- Subject:
- acute phase proteins; anemia; animal pathology; antibodies; antigens; blood serum; bone marrow; horses; immunohistochemistry; inflammation; lymphocytic leukemia; myeloid leukemia; neoplasm cells; neutropenia; thrombocytopenia
- Abstract:
- ... Leukemia is broadly divided into acute and chronic lymphocytic and myeloid types based on the proportion of blasts, morphology of cells, and expression of specific antigens on neoplastic cells. Classifying leukemia in horses can be challenging if blasts predominate and since few antibodies to identify cell types are available. The objective of this study was to describe in detail the clinical and ...
- DOI:
- 10.1177/0300985817720983
- https://doi.org/10.1177/0300985817720983
- Author:
- D. V. Tolle; T. M. Seed; T. E. Fritz; L. S. Lombard; C. M. Poole; W. P. Norris
- Source:
- Veterinary pathology v.16 no.2 pp. 243-254
- ISSN:
- 1544-2217
- Subject:
- Beagle; anemia; animal pathology; blood platelets; bone marrow; cell culture; cobalt; death; dogs; erythropoiesis; females; gamma radiation; gastrointestinal system; granulocytes; heart; histology; irradiation; kidneys; leukemia; liver; lymph nodes; monocytes; necropsy; neoplasm cells; purebreds; radionuclides; remission; spleen
- Abstract:
- ... A purebred female Beagle dog that had received 2,000 R of protracted whole-body γ-irradiation from ⁶⁰Co when 14 months old had hematologic changes consistent with a myeloproliferative disorder 3 years after the termination of radiation exposure. Peripheral blood and bone marrow findings during the 7-month period before death showed progressive anemia with increased numbers of platelets; immature g ...
- DOI:
- 10.1177/030098587901600210
- https://doi.org/10.1177/030098587901600210
- Author:
- M. M. Christopher; A. L. Metz; J. Klausner; D. Polzin; D. W. Hayden
- Source:
- Veterinary pathology v.23 no.2 pp. 140-147
- ISSN:
- 1544-2217
- Subject:
- dogs; leukemia; diagnostic techniques; bone marrow; lymph nodes; ultrastructure; cytochemistry; nervous system diseases
- Abstract:
- ... A dog was presented with mandibular paralysis, photophobia, and diffuse atrophy of the cranial skeletal muscles. Physical examination also revealed glossal paralysis, reduction of the swallowing reflex, reduction of the pupillary light response, and generalized lymphadenopathy. Cytologic and ultrastructural examinations of blood films, bone marrow, and lymph node aspirates were consistent with acu ...
- DOI:
- 10.1177/030098588602300206
- PubMed:
- 3457488
- https://doi.org/10.1177/030098588602300206
- Author:
- Yun-Li Zhao; Min Su; Jian-Hua Shang; Xia Wang; Guang-Lei Bao; Jia Ma; Qing-Di Sun; Fang Yuan; Jing-Kun Wang; Xiao-Dong Luo
- Source:
- Natural products and bioprospecting 2020 v.10 no.4 pp. 209-220
- ISSN:
- 2192-2195
- Subject:
- Alstonia scholaris; Beagle; bone marrow; databases; drugs; electrocardiography; gait; hematology; histopathology; indole alkaloids; mortality; mucosa; oral administration; tropical plants; urine; vomiting; China
- Abstract:
- ... Alstonia scholaris (L.) R. Br., an evergreen tropical plant rich in indole alkaloids with significant physiological activity, is traditionally used to treat respiratory diseases in China. This study was conducted to establish the toxicity profile of the alkaloid extract (TA) of A. scholaris leaves in non-rodents. After oral administration of a single dose (4 g/kg.bw), a number of transient symptom ...
- DOI:
- 10.1007/s13659-020-00246-0
- https://doi.org/10.1007/s13659-020-00246-0
- Author:
- Eva-Maria Laabs; Reinhard Mischke; Peter Dziallas; Arianna Maiolini; Andrea Tipold; Barbara Raddatz; Christina Puff; Jürgen Rehage
- Source:
- Acta veterinaria scandinavica 2015 v.57 no.1 pp. 48
- ISSN:
- 1751-0147
- Subject:
- Holstein; anemia; blood; bone marrow; calves; females; hemorrhage; histopathology; leukemia; magnetic resonance imaging; meninges; necropsy; neoplasm cells; neurological examination; neutropenia; paresis; spinal cord; thrombocytopenia; vertebrae
- Abstract:
- ... A three-month-old female Holstein–Friesian calf was presented with acute tetraparesis. After neurological examination a multifocal lesion in the central nervous system was suspected with the most pronounced lesions between the third thoracic and the third lumbar vertebrae. Haematological examination revealed moderate anaemia as well as severe thrombocytopenia, neutropenia and leucocytosis. A blood ...
- DOI:
- 10.1186/s13028-015-0141-z
- PubMed:
- 26335022
- PubMed Central:
- PMC4558832
- https://doi.org/10.1186/s13028-015-0141-z
- Author:
- Tajeldin Mohammedien Abdallah; Omer Mohammed Abd elbagi; Abuelgasim OsmanKaroum; Abdel Aziem Abdallah Ali
- Source:
- Asian Pacific Journal of Tropical Biomedicine 2014 v.4 pp. 751-754
- ISSN:
- 2221-1691
- Subject:
- Brucella; blood platelets; bone marrow; brucellosis; case studies; fever; hemorrhage; immunologic techniques; males; pain; patients; therapeutics; thrombocytopenia
- Abstract:
- ... A 25 year-old male patient was admitted to the causality with complaints of fever, joints pain, epistaxis and gingival bleeding, for the last week, the complete blood count revealed pancytopenia. Serological test for brucella was reported positive as 1/320, but the patient failed to respond to brucella treatment for 4 d. On day 5th the diagnosis of immune thrombocytopenia was confirmed after bone ...
- DOI:
- 10.12980/APJTB.4.2014C1324
- https://doi.org/10.12980/APJTB.4.2014C1324
- Author:
- Martha Lucía Díaz; Sandra Leal; Julio César Mantilla; Alfredo Molina-Berríos; Rodrigo López-Muñoz; Aldo Solari; Patricia Escobar; Clara Isabel González Rugeles
- Source:
- Parasites & vectors 2015 v.8 no.1 pp. 608
- ISSN:
- 1756-3305
- Subject:
- Schistosoma mansoni; antigens; bone marrow; cercariae; humans; immunomodulation; inflammation; interferon-gamma; interleukin-10; macrophage activation; macrophages; mice; parasites; receptors; ultracentrifugation
- Abstract:
- ... BACKGROUND: Outbreaks of acute Chagas disease associated with oral transmission are easily detected nowadays with trained health personnel in areas of low endemicity, or in which the vector transmission has been interrupted. Given the biological and genetic diversity of Trypanosoma cruzi, the high morbidity, mortality, and the observed therapeutic failure, new characteristics of these outbreaks ne ...
- DOI:
- 10.1186/s13071-014-0608-1
- PubMed:
- 25561160
- PubMed Central:
- PMC4297449
- https://doi.org/10.1186/s13071-014-0608-1
- Author:
- Jôse Mára de Brito; Thais Mauad; Guilherme Franco Cavalheiro; Kelly Yoshizaki; Paulo Afonso de André; Ana Julia F.C. Lichtenfels; Eliane Tigre Guimarães; Dolores Helena Rodriguez Ferreira Rivero; Leila Antonangelo; Luciano Basto Oliveira; Luiz Roberto Martins Pedroso; Mariangela Macchione; Paulo Hilário Nascimento Saldiva
- Source:
- Science of the total environment 2018 v.628-629 pp. 1223-1233
- ISSN:
- 0048-9697
- Subject:
- acute exposure; air; biodiesel; biomarkers; blood pressure; bone marrow; breathing; cell adhesion molecules; epithelium; erythrocytes; esters; heart rate; inducible nitric oxide synthase; inflammation; lungs; macrophages; mice; neutrophils; parenchyma (animal tissue); respiratory tract diseases; sewage
- Abstract:
- ... Biodiesel is a renewable energy source that reduces particle emission, but few studies have assessed its effects. To assess the effects of acute inhalation of two doses (600 and 1200 μg/m³) of diesel (DE) and biodiesel (BD) fuels on the inflammatory pulmonary and systemic profile of mice. Animals were exposed for 2 h in an inhalation chamber inside the Container Laboratory for Fuels. Heart rate, h ...
- DOI:
- 10.1016/j.scitotenv.2018.02.019
- https://doi.org/10.1016/j.scitotenv.2018.02.019
93. Acute genotoxicity analysis in vivo of the aqueous extract of Maytenus guyanensis Amazonian chichuá
- Author:
- Dionatas Ulises de Oliveira Meneguetti; Renato Abreu Lima; Francisco Carlos da Silva; Guilherme Matos Passarini; João Bezerra Facundo; Rubiani de Cassia Pagotto; Júlio Sancho Linhares Teixeira Militão; Valdir Alves Facundo
- Source:
- Revista Brasileira de Farmacognosia 2015 v.25 no.2 pp. 164-169
- ISSN:
- 0102-695X
- Subject:
- Maytenus; Mus musculus; bark; bioaccumulation; blood; bone marrow; comet assay; drugs; females; genotoxicity; long term effects; males; mechanism of action; medicinal properties; mice; mutagens; roots; stems; traditional medicine; Amazonia
- Abstract:
- ... The species Maytenus guyanensis Klotzsch ex Reissek, Celastraceae, present a wide variety of possible pharmacological activities and its roots and stems are used by popular medicine in the western Amazon rainforest. Few studies have demonstrated the genotoxic safety of the popular use of this species, and owing to this, the present study aimed to perform an analysis of the acute genotoxicity in vi ...
- DOI:
- 10.1016/j.bjp.2015.03.003
- https://doi.org/10.1016/j.bjp.2015.03.003
- Author:
- Emily A. Barrell; Midori Goto Asakawa; M. Julia B. Felippe; Thomas J. Divers; Tracy Stokol
- Source:
- Journal of veterinary diagnostic investigation v.29 no.4 pp. 529-535
- ISSN:
- 1943-4936
- Subject:
- B-lymphocytes; bone marrow; breeds; fever; histology; horses; kidneys; liver; lungs; lymph nodes; medical records; myeloid leukemia; neoplasm cells; spleen
- Abstract:
- ... Acute leukemia is rare in horses. Herein we describe historical, clinicopathologic, and postmortem findings in 6 horses with acute leukemia. Medical records of horses with >20% bone marrow blasts and cytochemical or immunophenotyping results were reviewed. Affected horses were 2–8 y of age and of different breeds and sex. Horses were presented acutely with nonspecific signs (e.g., fever, lethargy) ...
- DOI:
- 10.1177/1040638717707724
- https://doi.org/10.1177/1040638717707724
- Author:
- Ledieu, D.; Palazzi, X.; Marchal, T.; Fournel-Fleury, C.
- Source:
- Veterinary clinical pathology 2005 v.34 no.1 pp. 52-56
- ISSN:
- 0275-6382
- Subject:
- leukemia; Dachshund; thrombosis; anemia; blood chemistry; alanine transaminase; males; spleen; bone marrow; case studies; lymph nodes; glycoproteins; lymphocyte antigens; physical activity; dogs; enzyme activity; disease diagnosis; liver; dog diseases; anorexia; erythrocytes; alkaline phosphatase
- Abstract:
- ... A 7-year-old, intact male Dachshund was presented to the Lyon veterinary school for lethargy and anorexia of several weeks duration. The main clinical signs were pale and icteric mucous membranes, hepatomegaly, splenomegaly, and lymphadenopathy. Results of a CBC and plasma biochemistry tests revealed severe nonregenerative anemia, thrombocytopenia, and increased alanine aminotransferase and alkali ...
- DOI:
- 10.1111/j.1939-165X.2005.tb00010.x
- PubMed:
- 15732019
- https://doi.org/10.1111/j.1939-165X.2005.tb00010.x
- Author:
- Ringger, N.C.; Ledens, L.; Bain, P.; Raskin, R.E.; LaRock, R.
- Source:
- Australian veterinary journal 1997 v.75 no.5 pp. 329-331
- ISSN:
- 0005-0423
- Subject:
- disease diagnosis; mares; leukemia; bone marrow; case studies
- DOI:
- 10.1111/j.1751-0813.1997.tb15702.x
- PubMed:
- 9196816
- https://doi.org/10.1111/j.1751-0813.1997.tb15702.x
- Author:
- Farideh Miraki-Moud; Fernando Anjos-Afonso; Katharine A. Hodby; Emmanuel Griessinger; Guglielmo Rosignoli; Debra Lillington; Li Jia; Jeff K. Davies; Jamie Cavenagh; Matthew Smith; Heather Oakervee; Samir Agrawal; John G. Gribben; Dominique Bonnet; David C. Taussig
- Source:
- Proceedings of the National Academy of Sciences of the United States of America 2013 v.110 no.33 pp. 13576-13581
- ISSN:
- 0027-8424
- Subject:
- bone marrow; hematopoiesis; hematopoietic stem cells; hemorrhage; humans; mice; myeloid leukemia; patients
- Abstract:
- ... Acute myeloid leukemia (AML) induces bone marrow (BM) failure in patients, predisposing them to life-threatening infections and bleeding. The mechanism by which AML mediates this complication is unknown but one widely accepted explanation is that AML depletes the BM of hematopoietic stem cells (HSCs) through displacement. We sought to investigate how AML affects hematopoiesis by quantifying residu ...
- DOI:
- 10.1073/pnas.1301891110
- PubMed:
- 23901108
- PubMed Central:
- PMC3746910
- https://doi.org/10.1073/pnas.1301891110
- Author:
- Joost H.A. Martens
- Source:
- international journal of biochemistry & cell biology 2011 v.43 no.10 pp. 1413-1416
- ISSN:
- 1357-2725
- Subject:
- transcription factors; hematopoiesis; stem cells; blood cells; bone marrow; mutants; myeloid leukemia
- Abstract:
- ... Acute myeloid leukemia is a cancer of the myeloid lineage, characterized by the rapid proliferation of immature progenitor cells which accumulate in the bone marrow and interfere with the production of normal blood cells. Aberrant regulation of E-twenty-six (ETS) specific transcription factors such as PU.1 (SPI1) is thought to play a major role in this type of leukemia. The importance of these fac ...
- DOI:
- 10.1016/j.biocel.2011.05.014
- https://doi.org/10.1016/j.biocel.2011.05.014
99. Acute myeloid leukemia: Therapy resistance and a potential role for tetraspanin membrane scaffolds
- Author:
- Muskan Floren; Jennifer M. Gillette
- Source:
- international journal of biochemistry & cell biology 2021 v.137 pp. 106029
- ISSN:
- 1357-2725
- Subject:
- bone marrow; cell biology; drug resistance; drug therapy; myeloid leukemia; relapse; remission
- Abstract:
- ... Acute myeloid leukemia (AML) is characterized by the disruption of myeloid differentiation and accumulation of blast cells in the bone marrow. While AML patients respond favorably to induction chemotherapy, long-term outcomes remain poor due to a high rate of chemoresistance. Advances with targeted therapies, which can be used in combination with conventional chemotherapy, have expanded therapeuti ...
- DOI:
- 10.1016/j.biocel.2021.106029
- https://doi.org/10.1016/j.biocel.2021.106029
- Author:
- Youn-Hwan Hwang; Hyunil Ha; Jin Yeul Ma
- Source:
- Journal of ethnopharmacology 2013 v.149 no.1 pp. 133-139
- ISSN:
- 0378-8741
- Subject:
- Dryopteris; acute toxicity; adverse effects; body weight; bone marrow; common cold; erythrocytes; genotoxicity; lethal dose 50; mice; mortality; rats; tapeworms; toxicity testing; China; Japan; Korean Peninsula
- Abstract:
- ... ETHNOPHARMACOLOGICAL RELEVANCE: Dryopteris crassirhizoma has been traditionally used for the treatment of tapeworm infestation, the common cold and cancer in Korea, China and Japan. Despite various pharmacological properties of Dryopteris crassirhizoma, there is no available information about the safety of Dryopteris crassirhizoma. AIM OF THIS STUDY: To ensure more information about the safety of ...
- DOI:
- 10.1016/j.jep.2013.06.011
- PubMed:
- 23773828
- https://doi.org/10.1016/j.jep.2013.06.011