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1. A nationwide wastewater-based assessment of metformin consumption across Australia

Author:
Dan Yang; Qiuda Zheng; Phong K. Thai; Fahad Ahmed; Jake W. O'Brien; Jochen F. Mueller; Kevin V. Thomas; Ben Tscharke
Source:
Environment international 2022 v.165 pp. 107282
ISSN:
0160-4120
Subject:
allopurinol; caffeine; education; environment; epidemiology; income; metformin; noninsulin-dependent diabetes mellitus; people; public health; statistics; wastewater treatment; watersheds; Australia
Abstract:
... Metformin is the most widely used drug to treat type 2 diabetes. Monitoring spatial patterns of metformin use could provide new insights into treatment of type 2 diabetes and the distribution among populations. This study applied a wastewater-based epidemiological (WBE) approach to estimate metformin use in different populations across Australia and compared these estimates with traditional approa ...
DOI:
10.1016/j.envint.2022.107282

2. A review toward contaminants of emerging concern in Brazil: Occurrence, impact and their degradation by advanced oxidation process in aquatic matrices

Author:
Eduardo O. Marson; Cleiseano E.S. Paniagua; Oswaldo Gomes Júnior; Bárbara R. Gonçalves; Valdislaine M. Silva; Ivo A. Ricardo; Maria Clara V. M. Starling; Camila C. Amorim; Alam G. Trovó
Source:
Science of the total environment 2022 v.836 pp. 155605
ISSN:
0048-9697
Subject:
bisphenol A; caffeine; electrochemistry; groundwater; hospitals; oxidation; ozonation; photocatalysis; pollution; rain; sanitation; seawater; surface water; wastewater; wastewater treatment; Brazil
Abstract:
... This work presents data regarding the occurrence and treatment of Contaminants of Emerging Concern (CECs) in Brazil in the past decade. The literature review (2011−2021) revealed the detection of 87 pharmaceutical drugs and personal care products, 58 pesticides, 8 hormones, 2 illicit drugs, caffeine and bisphenol A in distinct matrices (i.e.: wastewater, groundwater, sea water, rainwater, surface ...
DOI:
10.1016/j.scitotenv.2022.155605

3. Abundance, fate, and effects of pharmaceuticals and personal care products in aquatic environments

Author:
Adeyemi S. Adeleye; Jie Xue; Yixin Zhao; Alicia A. Taylor; Jenny E. Zenobio; Yian Sun; Ziwei Han; Omobayo A. Salawu; Yurong Zhu
Source:
Journal of hazardous materials 2022 v.424 pp. 127284
ISSN:
0304-3894
Subject:
analgesics; burden of disease; caffeine; demography; excretion; ibuprofen; municipal wastewater; population density; wastewater treatment
Abstract:
... Pharmaceuticals and personal care products (PPCPs) are found in wastewater, and thus, the environment. In this study, current knowledge about the occurrence and fate of PPCPs in aquatic systems—including wastewater treatment plants (WWTPs) and natural waters around the world—is critically reviewed to inform the state of the science and highlight existing knowledge gaps. Excretion by humans is the ...
DOI:
10.1016/j.jhazmat.2021.127284

4. Antiinflammatory and antiinfective effect of caffeine in a mouse model of disseminated salmonellosis

Author:
Betty Mancebo Dorvigny; Lethicia Souza Tavares; Ingrydt Alcântara de Almeida; Lucas Nunes Santana; Esther de Souza Silva; Juliana Kelly Urtigas de Souza; Anísio Francisco Soares; Valdemiro Amaro da Silva Júnior; José Vitor Lima‐Filho
Source:
Phytotherapy research 2022 v.36 no.4 pp. 1652-1663
ISSN:
0951-418X
Subject:
Salmonella Typhimurium; bacteria; blood flow; caffeine; cell viability; dexamethasone; inducible nitric oxide synthase; interleukin-6; intravenous injection; liver; macrophages; mice; microbial load; phagocytosis; phytotherapy; research; salmonellosis; spleen; tumor necrosis factor-alpha; virulence
Abstract:
... Caffeine has been reported for its antiinflammatory properties by stimulating phagocytosis. In this study, we investigated the antiinflammatory and antiinfective potential of caffeine in murine macrophage cell cultures and Swiss mice infected with virulent Salmonella enterica serotype typhimurium. Peritoneal macrophages (pMØ) were treated with caffeine on 96‐well plates for 24 hr and then infected ...
DOI:
10.1002/ptr.7349

5. Application of multispectral imaging combined with machine learning models to discriminate special and traditional green coffee

Author:
Winston Pinheiro Claro Gomes; Luís Gonçalves; Clíssia Barboza da Silva; Wanessa R. Melchert
Source:
Computers and electronics in agriculture 2022 pp. 107097
ISSN:
0168-1699
Subject:
agriculture; caffeine; catechin; data collection; electronics; fluorescence; fluorescent dyes; food analysis; food industry; reflectance
Abstract:
... Non-destructive techniques aided by machine learning models are widely implemented in food analysis. To discriminate between ‘special’ and ‘traditional’ classes of green coffee beans, an advanced multispectral imaging technique based on reflectance and autofluorescence data was employed in combination with four machine learning algorithms (SVM, RF, XGBoost, and CatBoost). Of the four algorithms, S ...
DOI:
10.1016/j.compag.2022.107097

6. Assessing Caffeine and Linear Alkylbenzene Sulfonate Effects on Molting and Reproduction of Daphnia magna by Quantitative and Qualitative Approaches

Author:
Mara R. de Lima e Silva; Aline C. Bernegossi; Gleyson B. Castro; Allan P. Ogura; Juliano J. Corbi; Mayara C. Felipe
Source:
Water, air, and soil pollution 2022 v.233 no.3 pp. 98
ISSN:
0049-6979
Subject:
Daphnia magna; air; caffeine; humans; keystone species; progeny; soil pollution; sulfonates; water
Abstract:
... Caffeine (CAF) and linear alkylbenzene sulfonate (LAS) are human activity indicators, classified as contaminants of emerging concern (CECs). The long-term effects of these CECs on keystone species are still scarce in the literature. In this study, the molting and reproduction of Daphnia magna were evaluated over chronicle experiments by quantitative and qualitative approaches. The reported environ ...
DOI:
10.1007/s11270-022-05554-4

7. Assessment of a wide array of organic micropollutants of emerging concern in wastewater treatment plants in Greece: Occurrence, removals, mass loading and potential risks

Author:
Anna Ofrydopoulou; Christina Nannou; Eleni Evgenidou; Aikaterini Christodoulou; Dimitra Lambropoulou
Source:
Science of the total environment 2022 v.802 pp. 149860
ISSN:
0048-9697
Subject:
UV filters; acetaminophen; caffeine; diclofenac; ecotoxicology; environment; fish; mass spectrometry; methotrexate; monitoring; organophosphorus compounds; pollutants; relative risk; risk assessment; solid phase extraction; surveys; telmisartan; toxicity; ultra-performance liquid chromatography; wastewater; wastewater treatment; Greece
Abstract:
... Exploring the contamination profile of multi-class emerging contaminants (ECs) in wastewater is highly desirable. To this end, the occurrence, removal, mass loading and risks associated with a large panel of pharmaceuticals and personal care products, illicit drugs, perfluorinated compounds and organophosphate flame retardants in two wastewater treatment plants (WWTPs) in the region of Thessalonik ...
DOI:
10.1016/j.scitotenv.2021.149860

8. Auditing the Representation of Female Versus Male Athletes in Sports Science and Sports Medicine Research: Evidence-Based Performance Supplements

Author:
Ella S. Smith; Alannah K. A. McKay; Megan Kuikman; Kathryn E. Ackerman; Rachel Harris; Kirsty J. Elliott-Sale; Trent Stellingwerff; Louise M. Burke
Source:
Nutrients 2022 v.14 no.5 pp. -
ISSN:
2072-6643
Subject:
beets; caffeine; creatine; evidence-based practice; females; glycerol; males; nitrates; sodium bicarbonate; women
Abstract:
... Although sports nutrition guidelines promote evidence-based practice, it is unclear whether women have been adequately included in the underpinning research. In view of the high usage rates of performance supplements by female athletes, we conducted a standardised audit of the literature supporting evidence-based products: β-alanine, caffeine, creatine, glycerol, nitrate/beetroot juice and sodium ...
DOI:
10.3390/nu14050953

9. Caffeine Ameliorates AKT-Driven Nonalcoholic Steatohepatitis by Suppressing De Novo Lipogenesis and MyD88 Palmitoylation

Author:
Xiangyun Tan; Yi Sun; Liang Chen; Junjie Hu; Yan Meng; Ming Yuan; Qi Wang; Shan Li; Guohua Zheng; Zhenpeng Qiu
Source:
Journal of agricultural and food chemistry 2022 v.70 no.20 pp. 6108-6122
ISSN:
1520-5118
Subject:
anti-inflammatory activity; caffeine; fatty liver; food chemistry; hepatoma; humans; interleukin-6; lipogenesis; mice; oncogenes; palmitoylation; therapeutics; thymoma
Abstract:
... Dysregulated hepatic lipogenesis represents a promising druggable target for treating nonalcoholic steatohepatitis (NASH). This work aims to evaluate the therapeutic efficacy of caffeine in a NASH mouse model displaying increased hepatic lipogenesis driven by constitutive hepatic overexpression of the active v-akt murine thymoma viral oncogene homolog (AKT). Caffeine was administered in the AKT mi ...
DOI:
10.1021/acs.jafc.2c01013

10. Caffeine Encapsulation in Metal Organic Framework MIL-53(Al) at Pilot Plant Scale for Preparation of Polyamide Textile Fibers with Cosmetic Properties

Author:
Beatriz Zornoza; César Rubio; Elena Piera; Miguel A. Caballero; Daniel Julve; Jorge Pérez; Carlos Téllez; Joaquín Coronas
Source:
ACS applied materials & interfaces 2022 v.14 no.19 pp. 22476-22488
ISSN:
1944-8252
Subject:
adsorption; caffeine; coordination polymers; fabrics; markets; microencapsulation; polyamides; porosity; temperature
Abstract:
... Currently in the marketplace, we can find clothing items able to release skin-friendly ingredients while wearing them. These innovative products with high-added value are based on microencapsulation technology. In this work, due to its lightness, flexibility, porosity, chemical affinity and adsorption capacity, metal–organic framework (MOF) MIL-53(Al) was the selected microcapsule to be synthesize ...
DOI:
10.1021/acsami.2c04293

11. Caffeine Inhibits Growth of Temozolomide-Treated Glioma via Increasing Autophagy and Apoptosis but Not via Modulating Hypoxia, Angiogenesis, or Endoplasmic Reticulum Stress in Rats

Author:
Jin-Cherng Chen; Juen-Haur Hwang
Source:
Nutrition and cancer 2022 v.74 no.3 pp. 1090-1096
ISSN:
1532-7914
Subject:
angiogenesis; apoptosis; autophagy; caffeine; caspase-3; endoplasmic reticulum stress; glioma; hypoxia; nutrition; vascular endothelial growth factors
Abstract:
... Thirty rats with glioma were divided into control group, temozolomide (TMZ) group (TMZ 30 mg/kg once daily for 5 day), and TMZ plus Caffeine group (TMZ 30 mg/kg once daily for 5 day and caffeine 100 mg/kg once daily for 2 weeks). The relative tumor fold and expression of hypoxia-induced factor-1α (HIF-1α), vascular endothelial growth factor (VEGF), neuropilin-1 (NRP-1), CCAAT/enhancer-binding prot ...
DOI:
10.1080/01635581.2021.1931361

12. Caffeine consumption and mortality in populations with different weight statuses: an analysis of NHANES 1999–2014

Author:
Ping Lin; Zongan Liang; Maoyun Wang
Source:
Nutrition 2022 pp. 111731
ISSN:
0899-9007
Subject:
National Health and Nutrition Examination Survey; caffeine; confidence interval; hazard ratio; mortality; nutrition; overweight; risk
Abstract:
... The association between caffeine consumption and mortality in different weight statuses is unclear. This study aimed to explore the effects of caffeine consumption on mortality in different weight statuses. Data from the National Health and Nutrition Examination Survey (NHANES) (1999-2014) was used in this study. We used multivariable Cox proportional hazards models with appropriate sampling weigh ...
DOI:
10.1016/j.nut.2022.111731

13. Caffeine intake and its influences on heart rate variability recovery in healthy active adults after exercise: A systematic review and meta-analysis

Author:
Andrey Alves Porto; Cicero Jonas R. Benjamim; Luana Almeida Gonzaga; Mariana Luciano de Almeida; Carlos Roberto Bueno Júnior; David M. Garner; Vitor Engrácia Valenti
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 v.32 no.5 pp. 1071-1082
ISSN:
0939-4753
Subject:
acute effects; caffeine; confidence interval; exercise; heart rate; ingestion; meta-analysis; metabolism; nutrition; risk analysis; standard deviation; systematic review
Abstract:
... Results regarding the effects of caffeine (CAF) intake on the autonomic control of heart rate recovery exercise remain inconclusive. Thus far, no study has used effect measures to pool the results of different experiments. We aim to assess the acute effect of CAF intake before exercise on the recovery of heart rate variability (HRV) after exercise through a systematic review and meta-analysis. Ran ...
DOI:
10.1016/j.numecd.2022.01.015

14. Changes in Non-Volatile and Volatile Metabolites Associated with Heterosis in Tea Plants (Camellia sinensis)

Author:
Pengjie Wang; Mengya Gu; Shuxian Shao; Xiaomin Chen; Binghao Hou; Naixing Ye; Xingtan Zhang
Source:
Journal of agricultural and food chemistry 2022 v.70 no.9 pp. 3067-3078
ISSN:
1520-5118
Subject:
Camellia sinensis; adenosine; adipic acid; caffeine; cultivars; flavanols; food chemistry; gallic acid; guanosine; heterosis; inosine; metabolites; metabolomics; nucleotides; odors; oolong tea; succinic acid; terpenoids
Abstract:
... Heterosis or hybrid vigor is extensively used in plant breeding. However, the contribution of metabolites to heterosis is still elusive. Here, we systematically identified the non-volatile and volatile metabolites of two hybrids and their parents in Camellia sinensis. The metabolomics analysis showed prevalent non-additive accumulation in hybrids, among which the non-additive nucleotides, alkaloid ...
DOI:
10.1021/acs.jafc.1c08248

15. Chemical Composition Analysis and Antioxidant Activity of Coffea robusta Monofloral Honeys from Vietnam

Author:
Nguyen Thi Nu Trinh; Nguyen Ngoc Tuan; Tran Dinh Thang; Ping-Chung Kuo; Nguyen Ba Thanh; Le Nhat Tam; Le Hong Tuoi; Trang H. D. Nguyen; Danh C. Vu; Thi L. Ho; Le Ngoc Anh; Nguyen Thi Thu Thuy
Source:
Foods 2022 v.11 no.3 pp. -
ISSN:
2304-8158
Subject:
Coffea canephora; antioxidant activity; caffeine; ferulic acid; flavonoids; freshness; gallic acid; high performance liquid chromatography; honey; hydroxymethylfurfural; principal component analysis; surveys; trigonelline; Nepal; Vietnam
Abstract:
... Monofloral honey samples (Coffea robusta) from Vietnam were determined for their chemical compositions. This is the first report on the chemical composition and antioxidant activity of coffee honey from Vietnam. These samples were characterized by their high contents of total and reducing sugars, total phenolic contents, and total flavonoid contents. The contents of seven phenolic acids (PAs) were ...
DOI:
10.3390/foods11030388

16. Chemical and sensory discrimination of coffee: impacts of the planting altitude and fermentation

Author:
Emanuele Catarina da Silva Oliveira; José Maria Rodrigues da Luz; Marina Gomes de Castro; Paulo Roberto Filgueiras; Rogério Carvalho Guarçoni; Eustáquio Vinicius Ribeiro de Castro; Marliane de Cássia Soares da Silva; Lucas Louzada Pereira
Source:
European food research & technology 2022 v.248 no.3 pp. 659-669
ISSN:
1438-2377
Subject:
altitude; caffeine; citrates; discriminant analysis; fermentation; food research; formic acid; malates; microbiome; nuclear magnetic resonance spectroscopy; quinic acid; sensory properties; soil; trigonelline
Abstract:
... Edaphoclimatic conditions, planting altitudes, soil, the microbiome of plants and fruits, genotypes, and postharvest processing are variables that contribute to the chemical and sensory quality of the coffee. Thus, the objective of this study was to evaluate the impacts of planting altitude and fermentation of fruits on the chemical and sensory quality of the coffee using Nuclear Magnetic Resonanc ...
DOI:
10.1007/s00217-021-03912-w

17. Chemical profiling of ancient bud black tea with a focus on the effects of shoot maturity and fermentation by UHPLC-HRMS

Author:
Yonglin Li; Ning Chen; Wenting Li; Huaqiao Lou; Yan Li; Qian Xiong; Ruoxue Bai; Jintao Wang; Yongdan Hu; Dabing Ren; Lunzhao Yi
Source:
European food research & technology 2022 v.248 no.5 pp. 1379-1393
ISSN:
1438-2377
Subject:
black tea; caffeine; chemical composition; epigallocatechin gallate; fermentation; flavanols; food research; isoquercitrin; polymerization; quercitrin; quinic acid; trees
Abstract:
... Ancient bud black tea (ABBT) is a special kind of black tea (BT) made from the bud of ancient tea tree. However, there is limited information about its chemical composition and the effects of shoot maturity and fermentation. By UHPLC-HRMS, 208 compounds including catechins, flavonoids, phenolic acids, alkaloids and others were qualitatively and quantitatively analyzed in ABBT. By comparison with t ...
DOI:
10.1007/s00217-022-03972-6

18. Chromosome‐level genome of Camellia lanceoleosa provides a valuable resource for understanding genome evolution and self‐incompatibility

Author:
Wenfang Gong; Shixin Xiao; Linkai Wang; Zhenyang Liao; Yihong Chang; Wenjuan Mo; Guanxing Hu; Wenying Li; Guang Zhao; Huaguo Zhu; Xiaoming Hu; Ke Ji; Xiaofeng Xiang; Qiling Song; Deyi Yuan; Shuangxia Jin; Lin Zhang
Source:
plant journal 2022 v.110 no.3 pp. 881-898
ISSN:
0960-7412
Subject:
Camellia sinensis; acetyl-CoA carboxylase; biosynthesis; caffeine; diacylglycerol acyltransferase; diploidy; flavanols; gametophytes; gene expression; genome assembly; genomics; glyceraldehyde-3-phosphate dehydrogenase; methyltransferases; oils; oleic acid; polyploidy; theanine; transcription (genetics)
Abstract:
... The section Oleifera (Theaceae) has attracted attention for the high levels of unsaturated fatty acids found in its seeds. Here, we report the chromosome‐scale genome of the sect. Oleifera using diploid wild Camellia lanceoleosa with a final size of 3.00 Gb and an N50 scaffold size of 186.43 Mb. Repetitive sequences accounted for 80.63% and were distributed unevenly across the genome. Camellia lan ...
DOI:
10.1111/tpj.15739

19. Competitive kinetics of adsorption onto activated carbon for emerging contaminants with contrasting physicochemical properties

Author:
Vinicius Diniz; Gabriela Rath; Susanne Rath; Larissa Sene Araújo; Davi Gasparini Fernandes Cunha
Source:
Environmental science and pollution research 2022 v.29 no.28 pp. 42185-42200
ISSN:
0944-1344
Subject:
activated carbon; adsorption; caffeine; coconuts; drugs; energy; liquid chromatography; models; pollution; porous media; research; solid phase extraction; sorption isotherms; tandem mass spectrometry; wastewater treatment
Abstract:
... Activated carbon (AC) can be used for the removal of emerging contaminants (e.g., drugs) in water and wastewater treatment plants. In the present study, we investigated the performance of two ACs (from coconut shell and Pinnus sp.) in the adsorption of caffeine, carbamazepine, and ricobendazole considering the compounds separately and in combination in batch-scale experiments. The concentrations o ...
DOI:
10.1007/s11356-021-16043-2

20. Comprehensive analysis of quality characteristics in main commercial coffee varieties and wild Arabica in Kenya

Author:
Collins Ogutu; Sylvia Cherono; Charmaine Ntini; Lu Wang; Yuepeng Han
Source:
Food chemistry: X 2022 v.14 pp. 100294
ISSN:
2590-1575
Subject:
Coffea arabica; antioxidant activity; caffeine; chlorogenic acid; discriminant analysis; flavor; food chemistry; odors; pH; pyrazines; sucrose; thiols; trigonelline; Kenya
Abstract:
... Coffee flavor is a complex commercial trait and its generation mechanisms remain largely unclear. Here, we investigated non-volatile and volatile compounds in the AA grade coffee beans of cultivated and wild Coffea arabica accessions in Kenya. An increased accumulation of trigonelline and sucrose along with a decreased accumulation of caffeine and 5-caffeoylquinic acid or chlorogenic acid (CGA) re ...
DOI:
10.1016/j.fochx.2022.100294

21. Comprehensive comparison on the chemical metabolites and taste evaluation of tea after roasting using untargeted and pseudotargeted metabolomics

Author:
Zongde Jiang; Zisheng Han; Mingchun Wen; Chi-Tang Ho; You Wu; Yijun Wang; Na Xu; Zhongwen Xie; Jinsong Zhang; Liang Zhang; Xiaochun Wan
Source:
Food science and human wellness 2022 v.11 no.3 pp. 606-617
ISSN:
2213-4530
Subject:
astringency; caffeine; flavanols; glycosides; humans; kaempferol; liquid chromatography; manufacturing; mass spectrometry; metabolites; metabolomics; procyanidins; quercetin; sensory evaluation; taste; tea; temperature; theobromine; water content
Abstract:
... Roasting is a common manufacture technology for processing various teas. It is not only used in decreasing the water content of finished tea, but also improving the flavor of teas. In the present study, the roasted and non-roasted teas were compared by liquid-chromatography mass spectrometry and sensory evaluation. The roasted tea tasted less bitter and astringent. The content of main galloylated ...
DOI:
10.1016/j.fshw.2021.12.017

22. Consumption of caffeinated and decaffeinated coffee enriched with cocoa and fructo‐oligosaccharides among non‐diabetic persons: Double blind randomized clinical trial

Author:
Márcio Flávio Moura de Araújo; Maria Wendiane Gueiros Gaspar; Vivian Saraiva Veras; Roberto Wagner Júnior Freire de Freitas; Maria do Livramento de Paula; Maria Aparecida Alves de Oliveira Serra; José Claudio Garcia Lira Neto; Marta Maria Coelho Damasceno; Ana Vládia Bandeira Moreira; Vanessa Derenji de Mello
Source:
Journal of food biochemistry 2022 v.46 no.5 pp. e14081
ISSN:
0145-8884
Subject:
arm circumference; biomarkers; blood glucose; body fat; caffeine; decaffeination; diabetes; diastolic blood pressure; food industry; fructooligosaccharides; glycemic control; markets; people; risk; waist circumference; weight loss
Abstract:
... Food industry has been investing in bringing to the market coffee‐based drinks enriched in compounds that promise weight loss, which consequently influences diabetes risk. However, there are no clinical trials showing the effects of brewed coffee (with or without caffeine) enriched with bioactive compounds on body fat and glycemic control in healthy individuals. Therefore, we have evaluated the ef ...
DOI:
10.1111/jfbc.14081

23. Decaffeination of wastewater using activated carbon produced from velvet tamarind-pericarp (Dialium Guineense)

Author:
Babalola Aisosa Oni; Samuel Eshorame Sanni; Samuel Olatunde Dahunsi; Bisike Chidiebere Egere
Source:
International journal of phytoremediation 2022 v.24 no.4 pp. 394-408
ISSN:
1549-7879
Subject:
Dialium guineense; adsorbents; adsorption; aqueous solutions; caffeine; decaffeination; endothermy; enthalpy; entropy; kinetics; pH; phytoremediation; sorption isotherms; wastewater
Abstract:
... Adsorption of caffeine from an aqueous solution was carried out using Velvet Tamarind-Pericarp, activated with H₃PO₄. The adsorbent was characterized using a scanning-electron microscope and the Brunauer-Emmett-Teller. Parameters such as activating agent concentration (80 wt.% in 100 mL solution), initial caffeine concentration of 5−40 g/L, pH of 0−14, and residence time 0−90 minutes, were investi ...
DOI:
10.1080/15226514.2021.1950118

24. Determination of methylxanthine contents and risk characterisation for various types of tea in Korea

Author:
Ga-Hyun Baek; Sung-Woong Yang; Choong-In Yun; Joon-Goo Lee; Young-Jun Kim
Source:
Food control 2022 v.132 pp. 108543
ISSN:
0956-7135
Subject:
Hibiscus; National Health and Nutrition Examination Survey; body weight; caffeine; calibration; detection limit; food intake; food safety; methylxanthines; risk; risk characterization; tea; theobromine; theophylline; Korean Peninsula
Abstract:
... Tea leaves contain methylxanthines, such as caffeine, which have various physiological and pharmacological effects in vivo. Caffeine, theobromine and theophylline were analysed in various teas to determine the exposure amount and health risk of methylxanthine intake from tea. All the determined validation parameters of the HPLC analysis method, which included specificity, linearity of the calibrat ...
DOI:
10.1016/j.foodcont.2021.108543

25. Differential expression of placental 11β-HSD2 induced by high maternal glucocorticoid exposure mediates sex differences in placental and fetal development

Author:
Pengxia Yu; Jin Zhou; Caiyun Ge; Man Fang; Yuanzhen Zhang; Hui Wang
Source:
Science of the total environment 2022 v.827 pp. 154396
ISSN:
0048-9697
Subject:
11-beta-hydroxysteroid dehydrogenase; abnormal development; animal models; birth weight; blood; caffeine; corticosterone; cortisol; fetal development; gene expression regulation; humans; males; placenta; pregnancy; progeny; synthetic glucocorticoids; umbilical cord
Abstract:
... A variety of adverse environmental factors during pregnancy cause maternal chronic stress. Caffeine is a common stressor, and its consumption during pregnancy is widespread. Our previous study showed that prenatal caffeine exposure (PCE) increased maternal blood glucocorticoid levels and caused abnormal development of offspring. However, the placental mechanism for fetal development inhibition cau ...
DOI:
10.1016/j.scitotenv.2022.154396

26. Discovery and Biochemical Characterization of N-methyltransferase Genes Involved in Purine Alkaloid Biosynthetic Pathway of Camellia gymnogyna Hung T.Chang (Theaceae) from Dayao Mountain

Author:
Meng-zhen Zhou; Dylan O'Neill Rothenberg; Wen Zeng; Li Luo; Chang-yu Yan; Zhen Zeng; Ya-hui Huang
Source:
Phytochemistry 2022 v.199 pp. 113167
ISSN:
0031-9422
Subject:
Camellia; Escherichia coli; S-adenosylmethionine; biochemical pathways; caffeine; genes; high performance liquid chromatography; methyltransferases; plant biochemistry; polymerase chain reaction; sequence analysis; tea; theobromine; transcriptome; xanthine
Abstract:
... In the present study, purine alkaloid analysis and transcriptome of Camellia gymnogyna Hung T. Chang (Theaceae) from Dayao Mountain were performed by high-performance liquid chromatography (HPLC) and RNA-Seq, respectively. The results showed that the major purine alkaloids accumulated in Camellia gymnogyna Hung T. Chang (Theaceae) were theobromine together with a small amount of theacrine and caff ...
DOI:
10.1016/j.phytochem.2022.113167

27. Ecdysteroid kinase-like (EcKL) paralogs confer developmental tolerance to caffeine in Drosophila melanogaster

Author:
Jack L. Scanlan; Paul Battlay; Charles Robin
Source:
Current research in insect science 2022 v.2 pp. 100030
ISSN:
2666-5158
Subject:
CRISPR-Cas systems; Drosophila melanogaster; adults; caffeine; fungi; genes; insects; kojic acid; loss-of-function mutation; metabolic detoxification; mutagenesis; phosphorylation; research; secondary metabolites; transcription (genetics); xenobiotics
Abstract:
... A unique aspect of metabolic detoxification in insects compared to other animals is the presence of xenobiotic phosphorylation, about which little is currently understood. Our previous work raised the hypothesis that members of the taxonomically restricted ecdysteroid kinase-like (EcKL) gene family encode the enzymes responsible for xenobiotic phosphorylation in the model insect Drosophila melanog ...
DOI:
10.1016/j.cris.2022.100030

28. Effect of Pu-erh tea on acetaminophen-induced hepatotoxicity assessed by physiological, metabolomic, and transcriptomic analyses

Author:
Xinxin Cao; Kangqing Zhang; Xuekai Wang; Fan Yao; Jing Sun; Yuanhang Li; Dandan Sun; Yujun Liu; Jinling Sui
Source:
Journal of functional foods 2022 v.92 pp. 105059
ISSN:
1756-4646
Subject:
acetaminophen; apoptosis; caffeine; dietary supplements; gene expression regulation; hepatotoxicity; inflammation; metabolism; metabolites; metabolomics; overdose; oxidative stress; tea; transcriptomics; tyrosine
Abstract:
... Acetaminophen (APAP) is a painkiller that can cause hepatotoxicity if taken in excess. We investigated the effect of pu-erh tea extract (PTE) on hepatotoxicity induced by excess APAP using physiological, metabolomic, and transcriptomic analyses. PTE decreased levels of oxidative stress, inflammatory response, and apoptosis markers induced by excess APAP. And 156 metabolites and 703 genes were iden ...
DOI:
10.1016/j.jff.2022.105059

29. Effects of 3 mg/kg Body Mass of Caffeine on the Performance of Jiu-Jitsu Elite Athletes

Author:
María Merino-Fernández; Verónica Giráldez-Costas; Jaime González-García; Jorge Gutiérrez-Hellín; Cristina González-Millán; Michelle Matos-Duarte; Carlos Ruiz-Moreno
Source:
Nutrients 2022 v.14 no.3 pp. -
ISSN:
2072-6643
Subject:
body weight; caffeine; cross-over studies; heart rate; ingestion; placebos
Abstract:
... The effects of caffeine were investigated in judo, boxing, taekwondo and Brazilian jiu-jitsu. However, this substance was never investigated regarding traditional jiu-jitsu. Therefore, the aim of this research was to analyze the effects of caffeine in the Special Judo Fitness Test (SJFT) and technical variables during combat in traditional jiu-jitsu elite athletes. Methods: Twenty-two young profes ...
DOI:
10.3390/nu14030675

30. Effects of caffeine ingestion on 8-km run performance and cognitive function after 26 hours of sleep deprivation

Author:
Amir Khcharem; Makram Souissi; Rim Atheymen; Lobna Ben Mahmoud; Zouheir Sahnoun
Source:
Biological rhythm research 2022 v.53 no.6 pp. 867-877
ISSN:
1744-4179
Subject:
biological rhythms; caffeine; cognition; placebos; research; sleep deprivation; sports
Abstract:
... The current study aimed to examine the effects of caffeine consumption on physical and cognitive performance after an endurance race following one night of sleep deprivation. Ten recreational runners performed four test sessions in a randomized order at 09:00 h after placebo or 5 mg/kg of caffeine ingestion during a baseline night (BN) (bedtime: from 22:30 h to 07:00 h) or a night of total sleep d ...
DOI:
10.1080/09291016.2020.1778975

31. Effects of caffeine on isometric handgrip strength: A meta-analysis

Author:
Jozo Grgic
Source:
Clinical nutrition ESPEN 2022 v.47 pp. 89-95
ISSN:
2405-4577
Subject:
caffeine; clinical nutrition; confidence interval; hand strength; ingestion; liquids; males; meta-analysis; placebos; risk assessment
Abstract:
... Several studies explored the effects of caffeine on isometric handgrip strength, but their findings varied. Therefore, the aim of this review was to perform a meta-analysis of studies exploring the effects of caffeine on isometric handgrip strength. Search for studies was performed through five databases (Academic Search Elite, Cochrane Library, PubMed/MEDLINE, SPORTDiscus, and Scopus) with additi ...
DOI:
10.1016/j.clnesp.2021.12.007

32. Effects of roasting on bioavailability and bioactivities of Vigna angularis and potential of coffee‐like beverage

Author:
Sibel Bolek
Source:
Journal of food science 2022 v.87 no.3 pp. 911-918
ISSN:
0022-1147
Subject:
Vigna angularis; antioxidant activity; bioavailability; caffeine; color; crude fiber; crude protein; flavor; fluidized beds; microwave ovens; nutritive value; odors; sensory evaluation
Abstract:
... Containing similar aroma and flavor profile of coffee after roasting, Vigna angularis have potential to be a caffeine‐free coffee‐like beverage. Microwave roasting process was conducted in a microwave oven at 600 W for 7, 14, and 21 min at 2‐min intervals, and fluidized bed roasting process was conducted in a fluidized bed roaster at 200°C for 9, 18, and 27 min. In order to compare the roasted bea ...
DOI:
10.1111/1750-3841.16048

33. Ergogenic property of Morinda citrifolia L. leaf extract affects energy metabolism in obese Sprague Dawley rats

Author:
Syafiq Zikri Salleh; Azizah Abdul Hamid; Ahmad Haniff Jaafar; Nor Diana Abdul Majid; Nazamid Saari; Hani Hafeeza Halim; Amin Ismail; Ahmad Faizal Abdul Razis; Nurul Shazini Ramli; Mohd Sabri Pak Dek
Source:
Journal of food biochemistry 2022 v.46 no.1 pp. e14027
ISSN:
0145-8884
Subject:
AMP-activated protein kinase; Morinda citrifolia; caffeine; catechin; cell lines; creatinine; energy; energy metabolism; epicatechin; ergogenic aids; functional foods; glucose; green tea; ingredients; lactate dehydrogenase; lactic acid; leaf extracts; leaves; muscles; quercetin; skeletal muscle; weight control; weight gain
Abstract:
... Ergogenic property is the ability to enhance capacity for physical activities through efficient production of energy and is potentially beneficial in weight management for the obese. In this study, ergogenic property of Morinda citrifolia leaf's extract (MCL) was evaluated using AMP‐activated protein kinase (AMPK) activity and high fat diet‐induced obese rats. Findings from the study showed that M ...
DOI:
10.1111/jfbc.14027

34. Glass transition effects on the molecular transport of caffeine from condensed k-carrageenan/polydextrose systems

Author:
Diah Ikasari; Vilia Darma Paramita; Stefan Kasapis
Source:
Food hydrocolloids 2022 v.126 pp. 107401
ISSN:
0268-005X
Subject:
Fourier transform infrared spectroscopy; caffeine; glass transition; glass transition temperature; hydrocolloids; mass transfer; polymers; potassium; spectral analysis; ultraviolet-visible spectroscopy
Abstract:
... We investigate the effect of added KCl on the glass transition of potassium-κ-carrageenan/polydextrose and molecular transport of caffeine. Samples were prepared with 2% (w/w) κ-carrageenan, 82% (w/w) polydextrose and 1% (w/w) caffeine to a total solids level of 85% (w/w). KCl was added at 0, 50, 100 and 200 mM to induce a dependence of structural properties on the potassium ion concentration. Hig ...
DOI:
10.1016/j.foodhyd.2021.107401

35. Ground coffee waste-derived carbon for adsorptive removal of caffeine: Effect of surface chemistry and porous structure

Author:
Daniel N. Mengesha; Medhen W. Abebe; Richard Appiah-Ntiamoah; Hern Kim
Source:
Science of the total environment 2022 v.818 pp. 151669
ISSN:
0048-9697
Subject:
adsorbents; adsorption; caffeine; carbon; decaffeination; diclofenac; environment; nitrogen; nitrogen content; porosity; temperature; wastes
Abstract:
... Carbon-based adsorbents show high adsorption capacity towards caffeine due to their porosity and surface functionality. However, the main limiting factor for high performance has not been addressed; furthermore, the adsorption interaction with different active sites needs to be explored. In this study, we synthesized a hierarchical porous nitrogen-doped carbon with unique surface functionality by ...
DOI:
10.1016/j.scitotenv.2021.151669

36. HPLC and high-throughput sequencing revealed higher tea-leaves quality, soil fertility and microbial community diversity in ancient tea plantations: compared with modern tea plantations

Author:
Guangrong Yang; Dapeng Zhou; Renyuan Wan; Conglian Wang; Jin Xie; Cunqiang Ma; Yongmei Li
Source:
BMC plant biology 2022 v.22 no.1 pp. 239
ISSN:
1471-2229
Subject:
Ascomycota; bacterial communities; caffeine; cation exchange capacity; community structure; epigallocatechin; fungal communities; gallic acid; high performance liquid chromatography; nitrogen; pH; phosphorus; potassium; soil fertility; soil microorganisms; soil organic carbon; sustainable development; tea; total nitrogen; total phosphorus
Abstract:
... BACKGROUND: Ancient tea plantations with an age over 100 years still reserved at Mengku Town in Lincang Region of Yunan Province, China. However, the characteristic of soil chemicophysical properties and microbial ecosystem in the ancient tea plantations and their correlation with tea-leaves chemical components remained unclear. Tea-leaves chemical components including free amino acids, phenolic c ...
DOI:
10.1186/s12870-022-03633-6

37. Identification of explanatory factors of the presence and quantification of endocrine disruptors in commercially available bottled waters

Author:
Andrés M. Enríquez‐Hidalgo; Jaime Lara‐Borrero; Andrés Torres
Source:
Water and environment journal 2022 v.36 no.1 pp. 30-42
ISSN:
1747-6585
Subject:
acetaminophen; bisphenol A; bottled water; caffeine; environment; fluoxetine; gemfibrozil; glass; phthalates; progesterone; triclosan; water
Abstract:
... To identify the factors that influence the presence and quantification of endocrine disruptors (EDs) in bottled water marketed in Bogotá, the packaging (plastic or glass), gas (sparkling or still water) and origin (international or Colombian) of the water were considered. EDs were divided into plasticizers, drugs and hormones and were quantitatively determined via gas chromatography coupled to mas ...
DOI:
10.1111/wej.12752

38. Illicit drugs street samples and their cutting agents. The result of the GC-MS based profiling define the guidelines for sensors development

Author:
Anna Żubrycka; Andrzej Kwaśnica; Monika Haczkiewicz; Karolina Sipa; Konrad Rudnicki; Sławomira Skrzypek; Lukasz Poltorak
Source:
Talanta 2022 v.237 pp. 122904
ISSN:
0039-9140
Subject:
Cannabis sativa; amphetamine; caffeine; cocaine; gas chromatography-mass spectrometry; methadone; methamphetamines
Abstract:
... In this work, we have focused on the profiling of 5647 street samples covering marijuana, common and new recreational illicit drugs. All samples were analyzed using gas chromatography-mass spectrometry (GC-MS) technique. In total we have identified 53 illicit drugs with Δ-9-tetrahydrocannabinol (THC), amphetamine, N-ethylhexedrone, 3,4-methylenedioxy methamphetamine (MDMA), 4-chloromethcathinone ( ...
DOI:
10.1016/j.talanta.2021.122904

39. Impact of COVID19 restrictions on organic micropollutants in wastewater treatment plants and human consumption rates

Author:
Camilla Di Marcantonio; Agostina Chiavola; Valentina Gioia; Alessandro Frugis; Giancarlo Cecchini; Claudia Ceci; Massimo Spizzirri; Maria Rosaria Boni
Source:
Science of the total environment 2022 v.811 pp. 152327
ISSN:
0048-9697
Subject:
COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; caffeine; cocaine; environment; humans; lifestyle; nitrogen; pandemic; people; phosphorus; pollutants; sewage; statistical analysis; sulfadiazine; sulfamethoxazole; surface water; trimethoprim; wastewater treatment; water quality; watersheds; Italy
Abstract:
... COVID19 pandemic and the consequent restrictions to constrain SARS-CoV-2 spreading produced several impacts on the worldwide population. The present study focused on 10 Organic Micropollutants (illicit drugs, pharmaceuticals including some antibiotics and caffeine) and aimed to assess: (1) if COVID19 pandemic restrictions affected the load of those contaminants released into the sewage network and ...
DOI:
10.1016/j.scitotenv.2021.152327

40. Impacts of caffeine on resistant chicken's performance and cardiovascular gene expression

Author:
Mohammad Kamely; Mohammad Amir Karimi Torshizi; James West; Theo Niewold
Source:
Journal of animal physiology and animal nutrition 2022 v.106 no.3 pp. 566-574
ISSN:
0931-2439
Subject:
Gallus gallus; adenosine; animal models; animal nutrition; ascites; blood pressure; body weight; caffeine; dose response; gene expression; heart failure; hypertension; hypertrophy; mortality; serotonin; troponin T
Abstract:
... We previously reported a study on 288 broiler (Gallus gallus) chicks who received caffeine in water between days 3 and 42, at levels of 0, 6.25, 12.5, 25, 50 and 100 mg/kg body weight (BW)/day. In the previous report, we found that caffeine caused pulmonary hypertension (PH)‐associated mortality in a significant minority (20%–30%) of birds, including right ventricular hypertrophy and ascites. We h ...
DOI:
10.1111/jpn.13608

41. Indigenous Bacillus paramycoides spp. and Alcaligenes faecalis: sustainable solution for bioremediation of hospital wastewater

Author:
Aneeba Rashid; Safdar A. Mirza; Ciara Keating; Sikander Ali; Luiza C. Campos
Source:
Environmental technology 2022 v.43 no.12 pp. 1903-1916
ISSN:
1479-487X
Subject:
Alcaligenes faecalis; Bacillus cereus; bioremediation; caffeine; color; decolorization; diazepam; environmental technology; fabrics; freshwater; hospitals; irrigation; phenol; salicylic acid; wastewater; Pakistan
Abstract:
... Farmers near towns and cities are using a wide range of highly polluted wastewaters for crop irrigation in Pakistan due to severe freshwater shortage. The present study aimed to promote indigenous bacterial strains isolated from domestic, hospital, textile, pharmaceutical and mixed wastewaters to remove contaminants and colour and render these wastewaters safer for irrigation. Thirty seven bacteri ...
DOI:
10.1080/09593330.2020.1858180

42. Individual and competitive adsorption of ibuprofen and caffeine from primary sewage effluent by yeast-based activated carbon and magnetic carbon nanocomposite

Author:
Geórgia Labuto; Ana P. Carvalho; Ana S. Mestre; Mikaela S. dos Santos; Helen R. Modesto; Tiago Dias Martins; Sherlan G. Lemos; Heron D.T. da Silva; Elma Neide Vasconcelos Martins Carrilho; Wagner A. Carvalho
Source:
Sustainable chemistry and pharmacy 2022 v.28 pp. 100703
ISSN:
2352-5541
Subject:
activated carbon; adsorbents; adsorption; caffeine; desorption; ethanol; ferromagnetism; green chemistry; ibuprofen; industry; nanocomposites; sewage effluent
Abstract:
... Pharmaceuticals enter water bodies mainly through urban effluents harmful to the biota, inducing microbial resistance, and impacting hydric security. Activated carbon has been used for effluent treatment and associated with ferromagnetic nanoparticles can facilitate the separation of this adsorbent from an aqueous medium and improve the adsorption capacity. A yeast-based carbon (YC) prepared from ...
DOI:
10.1016/j.scp.2022.100703

43. Innovative and environmentally safe composites based on starch modified with dialdehyde starch, caffeine, or ascorbic acid for applications in the food packaging industry

Author:
Dagmara Bajer; Aleksandra Burkowska-But
Source:
Food chemistry 2022 v.374 pp. 131639
ISSN:
0308-8146
Subject:
X-ray diffraction; antioxidant activity; ascorbic acid; biodegradability; biodegradation; brittleness; caffeine; crosslinking; crystal structure; food chemistry; hydrophilicity; hydrophobicity; industry; starch
Abstract:
... Biodegradable films based on starch modified with ascorbic acid or caffeine and dialdehyde starch (DS) were evaluated towards their applications in the food packaging industry. The morphology of the films surface was observed with SEM and AFM. The chemical structure was examined with ATR-FTIR spectroscopy and X-ray diffraction. The mechanical, thermal and barrier properties of the films were exami ...
DOI:
10.1016/j.foodchem.2021.131639

44. Instrumental and bioanalytical assessment of pharmaceuticals and hormone-like compounds in a major drinking water source—wastewater receiving Zayandeh Rood river, Iran

Author:
Shima Kouhi Dehkordi; Hamed Paknejad; Ludek Blaha; Helena Svecova; Roman Grabic; Zdenek Simek; Alena Otoupalikova; Michal Bittner
Source:
Environmental science and pollution research 2022 v.29 no.6 pp. 9023-9037
ISSN:
0944-1344
Subject:
caffeine; dihydrotestosterone; drought; drugs; human health; pollution; research; risk; river water; rivers; surface water; surfactants; wastewater; Iran
Abstract:
... Zayandeh Rood river is the most important river in central Iran supplying water for a variety of uses including drinking water for approximately three million inhabitants. The study aimed to investigate the quality of water concerning the presence of pharmaceutical active compounds (PhACs) and hormonelike compounds, which have been only poorly studied in this region. Sampling was performed at seve ...
DOI:
10.1007/s11356-021-15943-7

45. Intracellular Ca2+ accumulation triggered by caffeine provokes resistance against a broad range of biotic stress in rice

Author:
Jong‐Chan Park; Youngchul Yoo; Hyemin Lim; Sopheap Yun; Kay Tha Ye Soe Win; Kyung‐Min Kim; Gang‐Seob Lee; Man‐Ho Cho; Tae Hoon Lee; Hiroshi Sano; Sang‐Won Lee
Source:
Plant, cell and environment 2022 v.45 no.4 pp. 1049-1064
ISSN:
0140-7791
Subject:
Fulgoroidea; biosynthesis; biotic stress; blast disease; caffeine; calcium; crop losses; environment; genetically modified organisms; leaf blight; methyltransferases; phenylalanine; rice; salicylic acid
Abstract:
... Chemical pesticides are still frequently overused to diminish such crop loss caused by biotic stress despite the threat to humans and the environment. Thus, it is urgent to find safer and more effective defense strategies. In this study, we report that caffeine, implanted through a transgenic approach, enhances resistance against variable biotic stresses in rice without fitness cost. Caffeine‐prod ...
DOI:
10.1111/pce.14273

46. Knowledge, Consumption Pattern, and Adverse Effects of Energy Drinks among Asian Population: A Cross-Sectional Analysis from Malaysia

Author:
Ali Haider Mohammed; Ali Blebil; Amutha Selvaraj; Zoena Jia Xuan Ang; Cui Yee Chong; Veronica Rui Sim Chu; Yi Qi Ku; Bassam Abdul Rasool Hassan; Abdulrasool M. Wayyes; Abdelhaleem Mustafa Madani
Source:
Journal of nutrition and metabolism 2022 v.2022 pp. -
ISSN:
2090-0732
Subject:
alcohols; caffeine; cross-sectional studies; energy; headache; markets; metabolism; nutrition; questionnaires; Malaysia
Abstract:
... Background. The frequent expansion of the energy drinks (EDs) market has caused an extensive increase in the consumption of EDs, especially among younger populations. However, the lack of knowledge on EDs and their perceived beneficial effects could lead to excessive EDs consumption, which is strongly associated with serious side effects. This study aimed to assess the knowledge and perceived bene ...
DOI:
10.1155/2022/3928717

47. Metabolite characterization of fifteen by-products of the coffee production chain: From farm to factory

Author:
Mariana Rodrigues da Silva; Felipe Sanchez Bragagnolo; Renato Lajarim Carneiro; Isabela de Oliveira Carvalho Pereira; José Antonio Aquino Ribeiro; Clenilson Martins Rodrigues; Rebecca E. Jelley; Bruno Fedrizzi; Cristiano Soleo Funari
Source:
Food chemistry 2022 v.369 pp. 130753
ISSN:
0308-8146
Subject:
caffeine; chlorogenic acid; cinnamic acid; farms; flavonoids; food chemistry; leaves; metabolites; wastewater
Abstract:
... Approximately 11.4 million tonnes of solid by-products and an increased amount of waste water will be generated during the 2020/21 coffee harvest. There are currently no truly value-adding uses for these potentially environmentally threatening species. This work presents the most wide-ranging chemical investigation of coffee by-products collected from farms to factories, including eight never prev ...
DOI:
10.1016/j.foodchem.2021.130753

48. Microbial ecology and functional coffee fermentation dynamics with Pichia kudriavzevii

Author:
Shankar S R; Sneha H P; Inderjit Prakash; Mahejibin Khan; Punil Kumar H N; Hari Om; K. Basavaraj; Pushpa S. Murthy
Source:
Food microbiology 2022 v.105 pp. 104012
ISSN:
0740-0020
Subject:
Acinetobacter; Coffea arabica; Lactobacillus; Leuconostoc; Mycobacterium; Pichia kudriavzevii; Rhodotorula; beans; bioactive properties; bioprocessing; caffeine; fermentation; flavor; furans; honey; malt; metabolites; metagenomics; pH; polyphenols; pyrazines; starter cultures; sugars; trigonelline; volatile compounds
Abstract:
... Specialty coffee can be developed by the application of explicit microorganisms or starters to obtain desired fermentation. In the present study, natural fermentation (NF) of Arabica coffee was carried out spontaneously, the other set was inoculated with Pichia kudriavzevii (Y) starter culture (isolated, identified and mass cultured). The effect of microbial fermentation, metagenomics, production ...
DOI:
10.1016/j.fm.2022.104012

49. Microbial fuel cell for simultaneous caffeine removal and bioelectricity generation under various operational conditions in the anodic and cathodic chambers

Author:
Kea-Lee Yap; Li-Ngee Ho; Soon-An Ong; Kun Guo; Yun-Ming Liew; Yoong-Sin Oon; Shen-Hui Thor; Sing-Mei Tan; Tean-Peng Teoh
Source:
Environmental technology & innovation 2022 v.25 pp. 102158
ISSN:
2352-1864
Subject:
acetates; anodes; bioelectricity; caffeine; decaffeination; electrochemistry; electron transfer; environmental technology; microbial fuel cells; power generation; salinity; sodium; sodium chloride
Abstract:
... A series of studies of the effects of operational parameters including organic substrate loading concentration, initial caffeine concentration, circuit connection, external resistance and salinity were carried out to evaluate the optimal performance of a double chambered microbial fuel cell for the treatment of caffeine. The increment of organic substrate loading concentration at anode increased t ...
DOI:
10.1016/j.eti.2021.102158

50. Non-destructive investigation of extracellular enzyme activities and kinetics in intact freshwater biofilms with mineral beads as carriers

Author:
Maria Riese; Tobias Schuetz; Marion Wacht; Klaus Fischer
Source:
Applied microbiology and biotechnology 2022 v.106 no.1 pp. 425-440
ISSN:
0175-7598
Subject:
arylsulfatase; biofilm; biotechnology; caffeine; ceramics; enzyme inhibition; extracellular enzymes; fluorometry; freshwater; glass; lava; leucyl aminopeptidase; liquids; membrane alanyl aminopeptidase; microbiology; streams
Abstract:
... Current procedures for fluorometric detection of extracellular hydrolytic enzyme activities in intact aquatic biofilms are very laborious and insufficiently standardized. To facilitate the direct determination of a multitude of enzymatic parameters without biofilm disintegration, a new approach was followed. Beads made of different mineral materials were subjected to biofilm growth in various aqua ...
DOI:
10.1007/s00253-021-11712-1

51. Nontargeted and targeted metabolomics analysis provides novel insight into nonvolatile metabolites in Jianghua Kucha tea germplasm (Camellia sinensis var. Assamica cv. Jianghua)

Author:
Wenliang Wu; Meiling Lu; Jiakun Peng; Haipeng Lv; Jiang Shi; Shuguang Zhang; Zhen Liu; Jihua Duan; Dan Chen; Weidong Dai; Zhi Lin
Source:
Food chemistry: X 2022 v.13 pp. 100270
ISSN:
2590-1575
Subject:
Camellia sinensis var. assamica; biosynthesis; bitterness; caffeine; catechin; cultivars; epigallocatechin; flavonols; food chemistry; germplasm; glycosides; metabolites; metabolomics; methylation; tea; China
Abstract:
... Jianghua Kucha (JHKC) is a special tea germplasm with high bitterness growing in China; however, the chemical characteristics of JHKC are not completely understood. In this study, 61 differential metabolites were identified between 11 wild JHKC individuals and 3 control cultivars of Fudingdabai, Yunkang 10, and Zhuyeqi using comprehensive nontargeted and targeted metabolomics approach. The JHKC ac ...
DOI:
10.1016/j.fochx.2022.100270

52. Pharmaceutical Contaminants in Shallow Groundwater and Their Implication for Poor Sanitation Facilities in Low‐Income Countries

Author:
Quyen Thi Thuy Do; Masahiro Otaki; Yurina Otaki; Chaminda Tushara; Ishara Wijesinghe Sanjeewa
Source:
Environmental toxicology and chemistry 2022 v.41 no.2 pp. 266-274
ISSN:
0730-7268
Subject:
Escherichia coli; caffeine; case studies; chemistry; chlorides; ecotoxicology; groundwater; groundwater contamination; nitrates; pollutants; risk; rural areas; sanitation; sulfamethoxazole; sustainable development; wastewater; Sri Lanka
Abstract:
... Rudimentary on‐site sanitation systems (OSSs) are extensively used in low‐income countries despite the risk of groundwater contamination. The present study investigated the potential impact of community soak pits on sandy shallow aquifers in a rural area in Sri Lanka. Thirty‐two groundwater samples were collected and measured for the traditional indicators fecal bacteria Escherichia coli, total co ...
DOI:
10.1002/etc.5110

53. Phenolic compounds from coffee by-products: Extraction and application in the food and pharmaceutical industries

Author:
Aline Felten Bondam; Daiele Diolinda da Silveira; Jaqueline Pozzada dos Santos; Jessica Fernanda Hoffmann
Source:
Trends in food science & technology 2022 v.123 pp. 172-186
ISSN:
0924-2244
Subject:
caffeine; chlorogenic acid; cosmetics; electric field; environmental impact; fermentation; flavonoids; pharmaceutical industry; ultrasonics; wastes
Abstract:
... Coffee by-products are generated along the coffee production chain, from harvest to brewing. The presence of phenolic compounds, caffeine, and flavonoids in coffee and its by-products has attracted attention with respect to their applications in foods and pharmaceutical matrices, especially considering the bioactive potential of these molecules. These by-products can be used as ingredients to redu ...
DOI:
10.1016/j.tifs.2022.03.013

54. Phytochemical investigation and bioactivity studies of flowers obtained from different cultivars of Camellia sinensis plant

Author:
Ranjana Sharma; Ajay Rana; Sanjay Kumar
Source:
Natural product research 2022 v.36 no.8 pp. 2166-2170
ISSN:
1478-6427
Subject:
Aspergillus niger; Camellia sinensis; Candida albicans; antifungal properties; antioxidant activity; caffeine; cultivars; diodes; flavanols; gallic acid; growth retardation; polyphenols; research; reversed-phase high performance liquid chromatography; theanine
Abstract:
... Investigation of major volatile and non-volatile phytochemicals from flowers of different cultivars of Camellia sinensis was performed. A total of 21 volatile constituents and 9 fatty acids were identified by gas chromatography -mass spectrometry (GC-MS). For evaluation of non-volatile constituents, reverse-phase high-performance liquid chromatography with diode array detection (RP-HPLC-DAD) is us ...
DOI:
10.1080/14786419.2020.1844696

55. Phytochemical profile and antioxidant potential of coffee leaves influenced by green extraction techniques and in vitro bio-accessibility of its functional compounds

Author:
Siddhi Patil; Vedashree M; Pushpa S. Murthy
Source:
Journal of food measurement & characterization 2022 v.16 no.3 pp. 2335-2346
ISSN:
2193-4126
Subject:
Coffea arabica; Coffea canephora; antioxidant activity; antioxidants; beverage industry; caffeine; calcium; chemical constituents of plants; chlorogenic acid; gastrointestinal system; measurement; microwave treatment; nutrient content; phenolic compounds; potassium; principal component analysis; quercetin; raw materials; theophylline; trigonelline; variance
Abstract:
... The present study aims to assess the nutritional composition and the impact of diverse green extraction techniques like conventional (CE), microwave-assisted (MAE), ultra-sound assisted (UAE), and brewing (BR) on the phytochemicals, antioxidant activities, and bio-accessibility of functional compounds by in vitro simulated gastrointestinal digestion from Coffea arabica and Coffea robusta leaves. T ...
DOI:
10.1007/s11694-022-01345-x

56. Plastic antioxidants: A family of cocaine cutting agents analyzed by short column gas chromatography-mass spectrometry

Author:
Luciano Chaves Arantes; Camilla Morandi da Silva; Eloisa Dutra Caldas
Source:
Journal of chromatography 2022 pp. 463170
ISSN:
0021-9673
Subject:
antioxidants; butylated hydroxytoluene; caffeine; cocaine; forensic sciences; gas chromatography-mass spectrometry; industry; lidocaine; police; temperature; Brazil
Abstract:
... Plastic antioxidants (PAOs), which are used in the industry to prevent degradation caused by thermo-mechanical or thermo-oxidative conditions, have been found in cocaine products seized by the Civil Police of the Federal District, Brazil, since 2019. In this study, a 4-meter short column gas chromatography-mass spectrometry qualitative method (GC-MS) was optimized and validated to detect cocaine, ...
DOI:
10.1016/j.chroma.2022.463170

57. Prevalence of caffeine consumers, daily caffeine consumption, and factors associated with caffeine use among active duty United States military personnel

Author:
Joseph J. Knapik; Ryan A. Steelman; Daniel W. Trone; Emily K. Farina; Harris R. Lieberman
Source:
Nutrition journal 2022 v.21 no.1 pp. 22
ISSN:
1475-2891
Subject:
National Health and Nutrition Examination Survey; alcohol drinking; body mass index; body weight; caffeine; candy; cross-sectional studies; energy; females; military personnel; questionnaires; regression analysis; tobacco use
Abstract:
... BACKGROUND: Although representative data on caffeine intake in Americans are available, these data do not include US service members (SMs). The few previous investigations in military personnel largely involve convenience samples. This cross-sectional study examined prevalence of caffeine consumers, daily caffeine consumption, and factors associated with caffeine use among United States active dut ...
DOI:
10.1186/s12937-022-00774-0

58. Probabilistic framework for assessing ecological risk of Contaminants of Emerging Concern: Application to a Canadian lake system

Author:
Gyan Chhipi-Shrestha; Manuel Rodriguez; Sonja Behmel; Rama Pulicharla; Francois Proulx; Kasun Hewage; Rehan Sadiq
Source:
Chemosphere 2022 v.287 pp. 131910
ISSN:
0045-6535
Subject:
acetaminophen; adverse outcome pathways; caffeine; contraceptives; drug residues; ecotoxicology; environmental assessment; freshwater fish; ibuprofen; lakes; phytoplankton; pollutants; probabilistic models; relative risk; risk estimate; salicylic acid; sulfamethoxazole; water pollution; zooplankton; Canada
Abstract:
... Contaminants of Emerging Concern (CECs) in natural water pose risks to ecosystems. The concentration of CECs varies spatially and temporally, and their estimated ecotoxicities differ widely by toxicological studies. This study extensively reviewed literature on ecological risk assessment and proposed a probabilistic framework for assessing ecological risk and its uncertainties (aleatory and episte ...
DOI:
10.1016/j.chemosphere.2021.131910

59. Profiling microbial removal of micropollutants in sand filters: Biotransformation pathways and associated bacteria

Author:
Jie Zhou; Donglin Wang; Feng Ju; Wanchao Hu; Jinsong Liang; Yaohui Bai; Huijuan Liu; Jiuhui Qu
Source:
Journal of hazardous materials 2022 v.423 pp. 127167
ISSN:
0304-3894
Subject:
Hydrogenophaga; Methylophilus; Rubrivivax; adsorption; atrazine; biotransformation; caffeine; demethylation; hydrolysis; manganese; metagenomics; oxidation; pollutants; quartz; sand; sand filters; sulfadiazine; sulfamethoxazole; trimethoprim
Abstract:
... Although there is growing evidence that micropollutants can be microbially converted in rapid sand filters of drinking water treatment plants (DWTPs), little is known about the biotransformation pathways and associated microbial strains in this process. Here, we constructed sand filter columns filled with manganese or quartz sand obtained from full-scale DWTPs to explore the biotransformation of e ...
DOI:
10.1016/j.jhazmat.2021.127167

60. Quantitative detection of caffeine in beverages using flowing atmospheric-pressure afterglow (FAPA) ionization high-resolution mass spectrometry imaging and performance evaluation of different thin-layer chromatography plates as sample substrates

Author:
Maximilian Heide; Cristian C. Escobar-Carranza; Carsten Engelhard
Source:
Analytical and bioanalytical chemistry 2022 v.414 no.15 pp. 4481-4495
ISSN:
1618-2642
Subject:
air; analytical chemistry; atmospheric pressure; black tea; caffeine; carbonated beverages; chemical species; desorption; glass; ionization; isotope labeling; liquids; mass spectrometry; quantitative analysis; silica; steel; thin layer chromatography
Abstract:
... Ambient desorption/ionization mass spectrometry (ADI-MS) is widely used as a rapid screening tool of samples in their native state without sample preparation. While analysis times are much less than 1 min per sample, one challenge of ADI-MS is the possibility to perform quantitative analysis of analytes in complex matrices. Typically, the goal is to probe a variety of different analytes in a compl ...
DOI:
10.1007/s00216-022-04045-z

61. Quantitative probabilistic assessment of caffeine intake from tea in Chinese adult consumers based on nationwide caffeine content determination and tea consumption survey

Author:
Ling Yong; Yan Song; Xiao Xiao; Haixia Sui; Haibin Xu; Rong Tan; Xiufang Yang; Jian Song; Jianwen Li; Sheng Wei
Source:
Food and chemical toxicology 2022 v.165 pp. 113102
ISSN:
0278-6915
Subject:
adults; beverages; black tea; caffeine; oolong tea; probability analysis; risk; surveys; toxicology
Abstract:
... Caffeine has known effects on the central nervous and cardiovascular systems. An intake up to 400 mg/day does not give rise to health concerns. Tea, a major source of caffeine, is highly consumed in China. However, the potential health risk of caffeine from tea has not been well evaluated. The present study assessed caffeine intake levels from tea for Chinese adult consumers. We collected 1,398 sa ...
DOI:
10.1016/j.fct.2022.113102

62. Quantitatively identifying the emission sources of pharmaceutically active compounds (PhACs) in the surface water: Method development, verification and application in Huangpu River, China

Author:
Xiping Kan; Shengya Feng; Xuebing Mei; Qian Sui; Wentao Zhao; Shuguang Lyu; Shuying Sun; Ziwei Zhang; Gang Yu
Source:
Science of the total environment 2022 v.815 pp. 152783
ISSN:
0048-9697
Subject:
Chama; caffeine; environment; factor analysis; livestock; models; municipal wastewater; rivers; sulfadiazine; surface water; China
Abstract:
... Recognizing the main sources of pharmaceutically active compounds (PhACs) found in surface waters has been a challenge to the effective control of PhAC contamination from the sources. In the present study, a novel method based on Characteristic Matrix (ChaMa) model of indicator PhACs to quantitatively identify the contribution of multiple emission sources was developed, verified, and applied in Hu ...
DOI:
10.1016/j.scitotenv.2021.152783

63. Reusability in visible light of titanate nanotubes for the removal of organic pollutants: role of calcination temperature

Author:
Ana Laura Ruiz-Castillo; Mariana Hinojosa-Reyes; Roberto Camposeco-Solis; Facundo Ruiz
Source:
Environmental technology 2022 v.43 no.14 pp. 2081-2098
ISSN:
1479-487X
Subject:
absorbance; adsorption; caffeine; dyes; environmental technology; hot water treatment; ion exchange; isopropyl alcohol; kinetics; light; nanotubes; photocatalysis; sorption isotherms; temperature; wastewater
Abstract:
... Titanate nanotubes (NTs) were synthesised by the hydrothermal method and later calcined at temperatures between 100–500°C. The calcined NTs were characterised and evaluated in the physicochemical adsorption of the safranin dye and photocatalytic degradation of caffeine. The materials calcined at low temperatures displayed a tubular structure and the H₂Ti₃O₇ crystalline phase, which was transformed ...
DOI:
10.1080/09593330.2020.1866085

64. Screening of α-glucosidase inhibitors in large-leaf yellow tea by offline bioassay coupled with liquid chromatography tandem mass spectrometry

Author:
You Wu; Zisheng Han; Mingchun Wen; Chi-Tang Ho; Zongde Jiang; Yijun Wang; Na Xu; Zhongwen Xie; Jinsong Zhang; Liang Zhang; Xiaochun Wan
Source:
Food science and human wellness 2022 v.11 no.3 pp. 627-634
ISSN:
2213-4530
Subject:
alpha-amylase; bioassays; black tea; caffeine; ethyl acetate; flavanols; food science; high performance liquid chromatography; humans; protein binding; tandem mass spectrometry; China
Abstract:
... Larger-leaf yellow tea (LYT) is a characteristic type of Chinese tea produced in Huoshan County, Anhui Province, which is made by mature leaves with stems. According to recent report, LYT showed competitive effects in anti-hyperglycemia in comparison to other teas such as green or black tea. However, the bioactive compounds of LYT are still undiscovered so far. For this purpose, 5 fractions of LYT ...
DOI:
10.1016/j.fshw.2021.12.019

65. Selection of Aptamers for Sensing Caffeine and Discrimination of Its Three Single Demethylated Analogues

Author:
Po-Jung Jimmy Huang; Juewen Liu
Source:
Analytical chemistry 2022 v.94 no.7 pp. 3142-3149
ISSN:
1520-6882
Subject:
blood serum; caffeine; calorimetry; detection limit; dissociation; fluorescence; humans; oligonucleotides; theobromine; theophylline; titration
Abstract:
... With the growing consumption of caffeine-containing beverages, detection of caffeine has become an important biomedical, bioanalytical, and environmental topic. We herein isolated four high-quality aptamers for caffeine with dissociation constants ranging from 2.2 to 14.6 μM as characterized using isothermal titration calorimetry. Different binding patterns were obtained for the three single demet ...
DOI:
10.1021/acs.analchem.1c04349

66. Sources of microbial contamination in the watershed and coastal zone of Soufriere, St. Lucia

Author:
Marsha Serville-Tertullien; Kareem Charlemagne; Newton Eristhee; Kevin McDermott; Anna Majury; Timo Schirmer; Tamanna Sultana; Chris D. Metcalfe
Source:
Environmental monitoring and assessment 2022 v.194 no.3 pp. 225
ISSN:
0167-6369
Subject:
Bacteroidales; Escherichia coli; caffeine; cattle; coasts; feces; fisheries; fluconazole; humans; microbial contamination; municipal wastewater; pollution; rivers; sanitation; sewage; sucralose; surface water; sustainable development; tourists; water quality; watersheds; Caribbean; Saint Lucia
Abstract:
... The Sustainable Development Goal 6 calls for global progress by 2030 in treating domestic wastewater and providing access to adequate sanitation facilities. However, meeting these goals will be a challenge for most Small Island Developing States, including Caribbean island nations. In the nearshore zone of the Soufriere region on the Caribbean island of St. Lucia, there is a history of high levels ...
DOI:
10.1007/s10661-022-09862-4

67. Specialty coffee consumption intervention illustrates the utility of behavior feedback messages

Author:
Nicholas P. Gallivan; Laura A. Brannon
Source:
Eating behaviors 2022 v.45 pp. 101630
ISSN:
1471-0153
Subject:
caffeine; coffee (beverage); cognition; memory; nutritional intervention; prices; surveys
Abstract:
... Despite having similar amounts of caffeine, “specialty” coffee drinks (SCDs; e.g., lattes and frappes) contain nearly 10 times as many calories and cost nearly double the price compared to more traditional coffee drinks (e.g., brewed and iced coffee). The current study examined the efficacy of generic and personalized behavior feedback messages to reduce participants' intention to consume SCDs, as ...
DOI:
10.1016/j.eatbeh.2022.101630

68. Spent coffee grounds by-products and their influence on soil C–N dynamics

Author:
Ana Cervera-Mata; Gabriel Delgado; Alejandro Fernández-Arteaga; Flavio Fornasier; Claudio Mondini
Source:
Journal of environmental management 2022 v.302 pp. 114075
ISSN:
0301-4797
Subject:
agricultural soils; biochar; biodiesel; caffeine; carbon dioxide; circular economy; energy; environmental management; gas chromatography; hydrochars; microbial biomass; microstructure; nitrogen cycle; nitrogen fertilizers; organic matter; pH; soil amendments; soil treatment; vermicomposts; wastes; water solubility
Abstract:
... SCG are a bio-waste generated in great amount worldwide which are attractive as soil amendment for their high content of organic matter and nutritive elements. Nevertheless, several studies have shown that soil application of untreated SCG has detrimental agronomic and environmental effects due to their high degradability and content of noxious compounds (phenols, caffeine, and tannins). However, ...
DOI:
10.1016/j.jenvman.2021.114075

69. Stability of proteins involved in initiation of DNA replication in UV damaged human cells

Author:
Boyka Borisova Anachkova; Vera Lyubchova Djeliova
Source:
Zeitschrift für Naturforschung 2022 v.77 no.3-4 pp. 113-123
ISSN:
1865-7125
Subject:
DNA damage; DNA replication; apoptosis; caffeine; caspases; cell cycle checkpoints; humans; phosphotransferases (kinases); proteasome endopeptidase complex; ultraviolet radiation
Abstract:
... The protein stability of the initiation factors Orc2, Orc3, Orc4, and Cdc6 was analyzed after UV light exposure in two human cell lines. In the cell line with higher repair capacity, HEK 293, no changes in the cell cycle distribution or in the protein levels of the investigated factors were detected. In HeLa cells that are characterized by lower repair capacity, UV irradiation caused a reduction o ...
DOI:
10.1515/znc-2020-0286

70. Synthesis and evaluation of novel xanthine‐acrylamides and xanthine‐acrylates as insecticidal agents

Author:
Shuyun Zhang; Hang Liu; Na Yang; Lixia Xiong; Baolei Wang
Source:
Pest management science 2022 v.78 no.5 pp. 2086-2095
ISSN:
1526-498X
Subject:
Mythimna separata; Plutella xylostella; acrylamides; acrylic acid; caffeine; cinnamic acid; insecticidal properties; insecticides; mass spectrometry; methylxanthines; structure-activity relationships; triflumuron; xanthine
Abstract:
... BACKGROUND: The design and discovery of novel pesticidal agents according to bioactive natural products is an important aspect of agrochemical innovation. New xanthine derivatives derived from natural xanthine or methylxanthines are rich resources that possess great potential to afford new active pesticidal molecules. Herein novel xanthine derivatives were designed through a strategy of combining ...
DOI:
10.1002/ps.6834

71. The association between caffeine intake and testosterone: NHANES 2013–2014

Author:
Frank E. Glover; William Michael Caudle; Francesco Del Giudice; Federico Belladelli; Evan Mulloy; Eniola Lawal; Michael L. Eisenberg
Source:
Nutrition journal 2022 v.21 no.1 pp. 33
ISSN:
1475-2891
Subject:
National Health and Nutrition Examination Survey; adults; blood serum; caffeine; cross-sectional studies; endocrine system; etiology; inflammation; metabolites; nutrition; regression analysis; testosterone; theobromine; theophylline; xanthine
Abstract:
... BACKGROUND: Caffeine is one of the most commonly used psychoactive drugs in the world, and provides many health benefits including alertness, improved memory, and reducing inflammation. Despite these benefits, caffeine has been implicated in a number of adverse health outcomes possibly due to effects within the endocrine system, effects that may contribute to impaired reproductive function and low ...
DOI:
10.1186/s12937-022-00783-z

72. The effect of trisodium phosphate crosslinking on the diffusion kinetics of caffeine from chitosan networks

Author:
Courtney Morrish; Felicity Whitehead; Taghrid Istivan; Stefan Kasapis
Source:
Food chemistry 2022 v.381 pp. 132272
ISSN:
0308-8146
Subject:
X-ray diffraction; caffeine; chitosan; crosslinking; food chemistry; polymers; porosity; sodium phosphate
Abstract:
... This work examines the relationship between microstructural properties of hot-moulded chitosan networks, crosslinked with trisodium phosphate, and diffusive behaviour from these networks. Analysis through infrared spectroscopy (FTIR) confirmed successful crosslinking of the polymer chains and bioactive entrapment, while X-ray diffraction (WAXD) and dynamic oscillation in-shear elucidated the highe ...
DOI:
10.1016/j.foodchem.2022.132272

73. The relative importance of internal and external physical resistances to mass transfer for caffeine release from apple pectin tablets

Author:
Shu Cheng; Chao Zhong; Timothy A.G. Langrish; Yongmei Sun; Zelin Zhou; Zexin Lei
Source:
Current research in food science 2022 v.5 pp. 634-641
ISSN:
2665-9271
Subject:
apples; benzoic acid; caffeine; diffusivity; digestion; food science; gastric juice; in vitro digestion; mass transfer; pectins; research
Abstract:
... The relative importance of the physical resistances to mass transfer have been explored by using halved 13 mm diameter apple-pectin tablets containing caffeine, in different external stirring environments within a beaker containing simulated gastric fluid. The effects of different external (outside of the tablets) mass-transfer resistances to the tablets created through two different stirrer types ...
DOI:
10.1016/j.crfs.2022.03.014

74. Treatment of Glaucoma with Natural Products and Their Mechanism of Action: An Update

Author:
Ru Hui Sim; Srinivasa Rao Sirasanagandla; Srijit Das; Seong Lin Teoh
Source:
Nutrients 2022 v.14 no.3 pp. -
ISSN:
2072-6643
Subject:
Cannabis sativa; Diospyros kaki; Ginkgo biloba; Lycium barbarum; Tripterygium wilfordii; anthocyanins; antioxidants; blindness; caffeine; coenzyme Q10; curcumin; eyes; forskolin; ganglia; ginsenosides; glaucoma; hesperidin; mechanism of action; nerve tissue; oxidative stress; pathogenesis; resveratrol; saffron; therapeutics
Abstract:
... Glaucoma is one of the leading causes of irreversible blindness. It is generally caused by increased intraocular pressure, which results in damage of the optic nerve and retinal ganglion cells, ultimately leading to visual field dysfunction. However, even with the use of intraocular pressure-lowering eye drops, the disease still progresses in some patients. In addition to mechanical and vascular d ...
DOI:
10.3390/nu14030534

75. Treatment of PPCPs and disinfection by-product formation in drinking water through advanced oxidation processes: Comparison of UV, UV/Chlorine, and UV/H2O2

Author:
Chih-Wei Pai; Gen-Shuh Wang
Source:
Chemosphere 2022 v.287 pp. 132171
ISSN:
0045-6535
Subject:
aspirin; benzophenones; byproducts; caffeine; chlorination; chlorine; deet; disinfection; human health; hydrogen peroxide; ibuprofen; oxidants; oxidation; pH; water treatment
Abstract:
... The presence of pharmaceutical and personal care products (PPCPs) in water is concerning because of their potential threat to ecosystems and human health. Studies have indicated that these emerging contaminants cannot be effectively removed through conventional water treatment. In this study, the efficacy of various treatments - chlorination, ultraviolet (UV), UV/Chlorine, and UV/H₂O₂ processes - ...
DOI:
10.1016/j.chemosphere.2021.132171

76. Understanding the bioaccumulation of pharmaceutical active compounds by clams Ruditapes decussatus exposed to a UWWTP discharge

Author:
Alexandra Cravo; Sofia Silva; João Rodrigues; Vítor Vale Cardoso; Maria João Benoliel; Cátia Correia; Maria Rosário Coelho; Maria João Rosa; Cristina M.M. Almeida
Source:
Environmental research 2022 v.208 pp. 112632
ISSN:
0013-9351
Subject:
Ruditapes decussatus; acetaminophen; bioaccumulation; caffeine; coastal water; diclofenac; high performance liquid chromatography; principal component analysis; research; salinity; solid phase extraction; tandem mass spectrometry; wastewater treatment; water solubility
Abstract:
... Twenty-four pharmaceutical active compounds (PhACs) were evaluated in the soft tissues of clams Ruditappes decussatus exposed along a 1.5-km dispersal gradient of the treated effluent from an urban wastewater treatment plant discharging in Ria Formosa, and compared with those in the marine waters and discharged effluents. The clams were exposed for 1 month, in June–July 2016, 2017 and 2018. PhACs ...
DOI:
10.1016/j.envres.2021.112632

77. Valorisation of Coffee Pulp for Development of Innovative Probiotic Beverage Using Kefir: Physicochemical, Antioxidant, Sensory Analysis and Shelf Life Studies

Author:
Siddhi Patil; Vaibhavi Pimpley; Kajol Warudkar; Pushpa S. Murthy
Source:
Waste and biomass valorization 2022 v.13 no.2 pp. 905-916
ISSN:
1877-2641
Subject:
anthocyanins; antioxidant activity; antioxidants; beverage industry; beverages; biomass; byproducts; caffeine; calcium; chlorogenic acid; coffee pulp; crude fiber; food composition; functional foods; glycemic effect; kefir; polyphenols; potassium; probiotics; sensory evaluation; shelf life; steam; wastes
Abstract:
... PURPOSE: Coffee pulp (CP), a by-product of coffee processing industry, was valorized as a functional food ingredient by exploring effects of different extractions on its phytochemicals and formulation of a novel beverage with probiotic kefir micro-organisms. METHODS: Wet coffee pulp was vacuum dried, pre-treated using steam (SCP) and viscozyme (VCP) followed by aqueous extraction of its phytochemi ...
DOI:
10.1007/s12649-021-01554-3

78. Whole-genome resequencing of Coffea arabica L. (Rubiaceae) genotypes identify SNP and unravels distinct groups showing a strong geographical pattern

Author:
Yeshitila Mekbib; Kassahun Tesfaye; Xiang Dong; Josphat K. Saina; Guang-Wan Hu; Qing-Feng Wang
Source:
BMC plant biology 2022 v.22 no.1 pp. 69
ISSN:
1471-2229
Subject:
Coffea arabica; beverages; caffeine; crops; gardens; gene banks; genes; genetic variation; genomics; germplasm; perennials; pests; phylogeny; recalcitrant seeds; sequence analysis; Ethiopia
Abstract:
... BACKGROUND: Coffea arabica L. is an economically important agricultural crop and the most popular beverage worldwide. As a perennial crop with recalcitrant seed, conservation of the genetic resources of coffee can be achieved through the complementary approach of in-situ and ex-situ field genebank. In Ethiopia, a large collection of C. arabica L. germplasm is preserved in field gene banks. Here, w ...
DOI:
10.1186/s12870-022-03449-4

79. ‘Green’ coagulant application with activated carbon: dosing sequence and removal of selected micropollutants and effluent organic matter from municipal wastewater

Author:
Ivana Ivančev-Tumbas; Minja Bogunović; Vesna Vasić; Marina Šćiban; Aleksandra Tubić; Anita Leovac Maćerak; Jelena Prodanović
Source:
Environmental technology 2022 v.43 no.8 pp. 1163-1169
ISSN:
1479-487X
Subject:
activated carbon; adsorption; beans; benzophenones; caffeine; chemical oxygen demand; coagulants; coagulation; decaffeination; environmental technology; hydrophilicity; hydrophobicity; municipal wastewater; organic matter; pollutants
Abstract:
... Combination of ‘green’ coagulation and powdered activated carbon adsorption was tested for removal of benzophenone (BP), benzophenone-3 (BP-3) and caffeine (CF) from treated municipal wastewater at realistic concentration levels (1–2 µg/L). At the same time it was tracked how the process affected effluent organic matter (EfOM) by measuring chemical oxygen demand (COD). Green coagulant was produced ...
DOI:
10.1080/09593330.2020.1821788

80. 140 Effect of addition of different concentrations of l-carnitine during porcine invitro maturation on embryo quality and development

Author:
P. R. Cruzans; M. S. Lorenzo; G. M. Teplitz; C. G. Luchetti; D. M. Lombardo
Source:
Reproduction, fertility, and development 2021 v.33 no.2 pp. 178
ISSN:
1031-3613
Subject:
antioxidant activity; apoptosis; blastocyst; boars; bovine serum albumin; caffeine; carnitine; catabolism; cyclic AMP; gonadotropins; humans; humidity; menopause; nucleotidyltransferases; oocytes; pyruvic acid; reactive oxygen species; semen; sodium lactate
Abstract:
... l-Carnitine (LC) plays an important role in the catabolism of lipids and protects cells from the damage caused by reactive oxygen species due to its antioxidant activity. The aim of this study was to evaluate the effect of adding different concentrations of LC during porcine invitro maturation on embryo quality and development. The cumulus–oocyte complexes were obtained by follicular aspiration fr ...
DOI:
10.1071/RDv33n2Ab140

81. 24-Epibrassinolide modulates the neurodevelopmental outcomes of high caffeine exposure in zebrafish (Danio rerio) embryos

Author:
Luís Félix; Carolina Lobato-Freitas; Sandra M. Monteiro; Carlos Venâncio
Source:
Comparative biochemistry and physiology 2021 v.249 pp. 109143
ISSN:
1532-0456
Subject:
Danio rerio; antioxidants; apoptosis; brassinosteroids; caffeine; edema; fish; neurotoxicity; oxidative stress; protective effect; tail; teratogenicity
Abstract:
... Previous embryonic fish data have shown caffeine to induce potential teratogenic and long-term neurodevelopmental outcomes through oxidative stress-mediated apoptosis. In this context, antioxidants may have the potential to counteract the caffeine-induced effects. Therefore, the present study aimed to investigate the potential protective role of 24-epibrassinolide (24-EPI), a natural brassinostero ...
DOI:
10.1016/j.cbpc.2021.109143

82. A Sulfonated Tweezer-Shaped Receptor Selectively Recognizes Caffeine in Water

Author:
Oscar Francesconi; Andrea Ienco; Francesco Papi; Marta Dolce; Andrea Catastini; Cristina Nativi; Stefano Roelens
Source:
Journal of organic chemistry 2022 v.87 no.5 pp. 2662-2667
ISSN:
1520-6904
Subject:
adenosine; caffeine; hydrogen; organic chemistry; sulfonates; xanthines
Abstract:
... The selective recognition of caffeine in water among structurally related xanthines and purine or pyrimidine bases was achieved by a simple tweezer-shaped receptor featuring sulfonate hydrosolubilizing groups. The remarkable affinity for caffeine, among the highest reported thus far in the literature and larger than that shown by adenosine receptors of all subtypes, stems from a synergistic combin ...
DOI:
10.1021/acs.joc.1c02620

83. A Systematic Review of the Effects of Caffeine on Basketball Performance Outcomes [Erratum: February 2022, v.11(3)]

Author:
Zhi Sen Tan; Alexiaa Sim; Masato Kawabata; Stephen F. Burns
Source:
Biology 2021 v.11 no.1 pp. -
ISSN:
2079-7737
Subject:
caffeine; ergogenic aids; genetic variation; metabolism; systematic review
Abstract:
... Caffeine is an ergogenic aid in many sports, including basketball. This systematic review examines the effects of caffeine on basketball-related skill tasks along with physical aspects of performance deemed important for the game. A systematic search was conducted across three databases (PubMed, SPORTDiscus and Web of Science) to identify randomized-controlled trials which examined the effect of c ...
DOI:
10.3390/biology11010017

84. A combined analytical-chemometric approach for the in vitro determination of polyphenol bioaccessibility by simulated gastrointestinal digestion

Author:
Esther Gómez-Mejía; Noelia Rosales-Conrado; María Eugenia León-González; Alejandro Valverde; Yolanda Madrid
Source:
Analytical and bioanalytical chemistry 2022 v.414 no.8 pp. 2739-2755
ISSN:
1618-2642
Subject:
antioxidant activity; bioactive compounds; bioavailability; caffeic acid; caffeine; chemometrics; chlorogenic acid; cluster analysis; decaffeination; digestion; diodes; duodenum; gallic acid; high performance liquid chromatography; in vitro digestion; molecular weight; multivariate analysis; polyphenols; principal component analysis; quercetin; resveratrol; tea
Abstract:
... In this study, an integrated characterisation through polyphenol and caffeine content and antioxidant activity was combined with chemometric analysis to assess the effects of simulated in vitro gastrointestinal digestion on the bioaccessibility of these bioactive compounds from nine different tea infusions. Tea infusions were characterised based on total flavonoids, total polyphenols and antioxida ...
DOI:
10.1007/s00216-022-03922-x

85. A drought‐responsive rice amidohydrolase is the elusive plant guanine deaminase with the potential to modulate the epigenome

Author:
Dhananjay Gotarkar; Toshisangba Longkumer; Naoki Yamamoto; Amrit Kaur Nanda; Tamara Iglesias; Lin‐Feng Li; Berta Miro; Elisa Blanco Gonzalez; Maria Montes Bayon; Kenneth M. Olsen; Yue‐Ie Caroline Hsing; Ajay Kohli
Source:
Physiologia plantarum 2021 v.172 no.4 pp. 1853-1866
ISSN:
0031-9317
Subject:
Arabidopsis; DNA methylation; DNA methyltransferase; adenosine; allantoin; artificial selection; caffeine; catabolism; chromosomes; epigenetics; epigenome; genes; guanine; nitrogen; phylogeny; rice; stress tolerance; tea; urea; ureides; water stress; xanthine
Abstract:
... Drought stress in plants causes differential expression of numerous genes. One of these differentially expressed genes in rice is a specific amidohydrolase. We characterized this amidohydrolase gene on the rice chromosome 12 as the first plant guanine deaminase (OsGDA1). The biochemical activity of GDA is known from tea and coffee plants where its catalytic product, xanthine, is the precursor for ...
DOI:
10.1111/ppl.13392

86. A dual-responsive nanozyme sensor with ultra-high sensitivity and ultra-low cross-interference towards metabolic biomarker monitoring

Author:
Xinyu Wang; Zhaoping Xia; Essy Kouadio Fodjo; Wei Deng; Dan Li
Source:
Journal of materials chemistry B 2022 v.10 no.16 pp. 3023-3031
ISSN:
2050-7518
Subject:
biomarkers; caffeine; chronic diseases; color; disease prevention; fluorescence; gluconic acid; glucose; glucose oxidase; hydrogen bonding; nanogold; point-of-care systems
Abstract:
... Accurate, sensitive and selective detection of metabolic biomarkers in biofluids are of vital significance for health self-monitoring and chronic disease prevention. Here, for the first time, a smart dual-responsive nanozyme sensor (DNS) was developed for simultaneous analysis of glucose and caffeine utilizing stimuli-responsive yolk–shell gold nanoparticles (GNPs)-embedded MIL-53 (Al) (GNPs@MIL-5 ...
DOI:
10.1039/d1tb02796d

87. A neonicotinoid pesticide alters how nectar chemistry affects bees

Author:
Sarah K. Richman; Isabelle M. Maalouf; Angela M. Smilanich; Denyse Marquez Sanchez; Sharron Z. Miller; Anne S. Leonard
Source:
Functional ecology 2022 v.36 no.4 pp. 1063-1073
ISSN:
0269-8463
Subject:
Bombus impatiens; acute exposure; bees; caffeine; chemistry; diet; digoxin; ecology; imidacloprid; immune response; longevity; nectar; pollen; reproduction; secondary metabolites; terpenoids; thymol
Abstract:
... Neonicotinoid pesticides in the nectar and pollen of managed crops and wildflowers contribute to the global declines of bees. These chemicals can have detrimental effects on bees' physiology, behaviour and reproduction. Floral nectar also contains secondary chemistry with its own effects on bee health. How nectar secondary chemistry may act additively or synergistically with neonicotinoids is unkn ...
DOI:
10.1111/1365-2435.14016

88. A new approach on synergistic effect and chemical stability of graphene oxide-magnetic nanocomposite in the heterogeneous Fenton degradation of caffeine [Erratum: April 2022, v.29(18); p.27611]

Author:
Manuel Alejandro Ramirez-Ubillus; Nayara de Melo Costa-Serge; Peter Hammer; Raquel Fernandes Pupo Nogueira
Source:
Environmental science and pollution research 2021 v.28 no.39 pp. 55014-55028
ISSN:
0944-1344
Subject:
X-ray diffraction; adsorption; caffeine; catalysts; catalytic activity; crystallites; decaffeination; graphene; graphene oxide; hydrogen peroxide; infrared spectroscopy; magnetite; mass transfer; nanocomposites; pollution; research; synergism; transmission electron microscopy
Abstract:
... Two compositions of graphene oxide-magnetite nanocomposites were studied as catalysts in the heterogeneous Fenton process. Transmission electron microscopy and X-ray diffraction revealed that the graphene oxide sheets were covered with nanoparticles of magnetite, with an average crystallite size of 7 nm. Infrared spectroscopy analysis indicated that the phases interacted through covalent Fe-O-C bo ...
DOI:
10.1007/s11356-021-14714-8

89. A reconnaissance study of pharmaceuticals, pesticides, perfluoroalkyl substances and organophosphorus flame retardants in the aquatic environment, wild plants and vegetables of two Saudi Arabia urban areas: Environmental and human health risk assessment

Author:
Yolanda Picó; Julian Campo; Ahmed H. Alfarhan; Mohamed A. El-Sheikh; Damià Barceló
Source:
Science of the total environment 2021 v.776 pp. 145843
ISSN:
0048-9697
Subject:
abamectin; acetaminophen; acetamiprid; aquatic environment; bisphenol A; caffeine; cumulative risk assessment; diazinon; diclofenac; farms; health effects assessments; human health; humans; ibuprofen; imidacloprid; perfluorocarbons; phosphates; risk; sulfonates; surface water; vegetation; Saudi Arabia
Abstract:
... In this study, the occurrence of 12 organophosphorus flame retardants (OPFRs), 64 pesticides, 21 perfluoroalkyl substances (PFASs) and 34 pharmaceuticals and personal care products (PPCPs) in surface water, sediments and vegetation collected from seven locations along the South Riyadh and six locations along the Al-Jubail industrial city (Saudi Arabia) were reported. The median of the concentratio ...
DOI:
10.1016/j.scitotenv.2021.145843

90. A short-term effect of caffeinated beverages on blood pressure: A meta-analysis of randomized controlled trails

Author:
Zhican Xu; Qingshu Meng; Xinyu Ge; Rulin Zhuang; Jing Liu; Xiaoting Liang; Huimin Fan; Ping Yu; Liang Zheng; Xiaohui Zhou
Source:
Journal of functional foods 2021 v.81 pp. 104482
ISSN:
1756-4646
Subject:
adolescents; adults; blood pressure; caffeine; meta-analysis
Abstract:
... Blood pressure alteration after taking caffeinated beverages is controversial. We performed a meta-analysis to synthesize the evidence on the relation between short time caffeinated beverages consumption and blood pressure from randomized controlled trials. PubMed and Web of Science were systematically searched. Ultimately 11 articles and 470 enrolled subjects were included in the present meta-ana ...
DOI:
10.1016/j.jff.2021.104482

91. Acetylcholinesterase Activity Monitoring and Natural Anti-neurological Disease Drug Screening via Rational Design of Deep Eutectic Solvents and CeO₂-Co(OH)₂ Nanosheets

Author:
Yun Liu; Xing Wei; Jia Chen; Yong-Liang Yu; Jian-Hua Wang; Hongdeng Qiu
Source:
Analytical chemistry 2022 v.94 no.15 pp. 5970-5979
ISSN:
1520-6882
Subject:
acetylcholinesterase; analytical chemistry; aqueous solutions; berberine; caffeine; catalytic activity; colorimetry; nanosheets; neostigmine; oxygen; proline; solvents; therapeutics
Abstract:
... The activity monitoring of acetylcholinesterase (AChE) and the screening of its inhibitors are critical for the diagnosis and therapy of neurological diseases. Herein, CeO₂-Co(OH)₂ nanosheets were synthesized for the first time in a newly designed deep eutectic solvent (DES) composed of l-proline and Ce(NO₃)₃·6H₂O, and a colorimetric assay was developed for quantitative detection of AChE and anti- ...
DOI:
10.1021/acs.analchem.2c00428

92. Achieving an Optimal Fat Loss Phase in Resistance-Trained Athletes: A Narrative Review

Author:
Carlos Ruiz-Castellano; Sergio Espinar; Carlos Contreras; Fernando Mata; Alan A. Aragon; José Miguel Martínez-Sanz
Source:
Nutrients 2021 v.13 no.9 pp. -
ISSN:
2072-6643
Subject:
aesthetics; body weight changes; caffeine; carbohydrate intake; creatine; diet; energy intake; lean body mass; protein intake; strength training; weight loss
Abstract:
... Managing the body composition of athletes is a common practice in the field of sports nutrition. The loss of body weight (BW) in resistance-trained athletes is mainly conducted for aesthetic reasons (bodybuilding) or performance (powerlifting or weightlifting). The aim of this review is to provide dietary–nutritional strategies for the loss of fat mass in resistance-trained athletes. During the we ...
DOI:
10.3390/nu13093255

93. Acute Effects of Low Dose of Caffeine Ingestion Combined with Conditioning Activity on Psychological and Physical Performances of Male and Female Taekwondo Athletes

Author:
Ibrahim Ouergui; Nourhene Mahdi; Slaheddine Delleli; Hamdi Messaoudi; Hamdi Chtourou; Zouheir Sahnoun; Anissa Bouassida; Ezdine Bouhlel; Hadi Nobari; Luca Paolo Ardigò; Emerson Franchini
Source:
Nutrients 2022 v.14 no.3 pp. -
ISSN:
2072-6643
Subject:
caffeine; cross-over studies; emotions; females; ingestion; males; placebos
Abstract:
... This study investigated low-dose caffeine ingestion, conditioning activity (CA) effects on psycho-physical performances in young taekwondo athletes. In a randomized, double-blind, counterbalanced, crossover design, 20 athletes (10 males; 17.5 ± 0.7 yrs) performed taekwondo-specific agility test (TSAT), 10 s/multiple frequency speed of kick test (FSKT-10s/FSKT-mult) after ingesting 3 mg·kg⁻¹ caffei ...
DOI:
10.3390/nu14030571

94. Acute caffeine mouth rinsing does not improve 10-km running performance in CYP1A2 C-allele carriers

Author:
Nayra Figueiredo; Marcela Queiroz; Fernanda P. Felício; Jéssica Ferreira; Jose Gerosa-Neto; João F. Mota; Christielly R. da Silva; Paulo C. Ghedini; Bryan Saunders; Gustavo D. Pimentel
Source:
Clinical nutrition ESPEN 2021 v.42 pp. 93-97
ISSN:
2405-4577
Subject:
blood; caffeine; cellulose; clinical nutrition; cross-over studies; heterozygosity; homozygosity; laboratories; mouth; placebos; water
Abstract:
... This study assessed whether caffeine mouth rinsing affects 10-km run performance and vertical jump in recreational runners. A double-blind, placebo-controlled, crossover study was conducted. Ten well-trained volunteers performed two trials, following caffeine or placebo mouth rinse, separated by seven days. Immediately before the 10-km run, a 10-second mouth rinse with either 300 mg of caffeine (1 ...
DOI:
10.1016/j.clnesp.2021.02.012

95. Acute effects of two caffeine doses on bar velocity during the bench press exercise among women habituated to caffeine: a randomized, crossover, double-blind study involving control and placebo conditions

Author:
Aleksandra Filip-Stachnik; Michal Krzysztofik; Juan Del Coso; Michal Wilk
Source:
European journal of nutrition 2022 v.61 no.2 pp. 947-955
ISSN:
1436-6207
Subject:
body weight; caffeine; exercise; ingestion; nutrition; placebos
Abstract:
... PURPOSE: The main goal of this study was to evaluate the effectiveness of two different doses of caffeine (3 and 6 mg/kg) to enhance bar velocity during the bench press in women habituated to caffeine. METHODS: Twelve recreationally trained women (age: 23.3 ± 0.8 years, body mass: 60.7 ± 5.7 kg, bench press one-repetition maximum (1RM): 44.3 ± 7.8 kg, daily caffeine ingestion: 5.7 ± 2.0 mg/kg/day) ...
DOI:
10.1007/s00394-021-02708-8

96. Adherence to healthy food choices during the COVID-19 pandemic in a U.S. population attempting to lose weight

Author:
Ellen S. Mitchell; Qiuchen Yang; Heather Behr; Laura Deluca; Paul Schaffer
Source:
Nutrition, metabolism, and cardiovascular diseases 2021 v.31 no.7 pp. 2165-2172
ISSN:
0939-4753
Subject:
COVID-19 infection; age; alcohol drinking; behavior change; caffeine; fruits; gender; healthy diet; lean meat; metabolism; population; processed meat; raw fruit; red meat; spring; supply; vegetable consumption; weight loss
Abstract:
... Food preferences are often modified in populations during stressful, unanticipated events. We examined how a U.S. population's food choices changed during the beginning of the COVID-19 stay-at-home orders, specifically during the spring of 2020.Daily dietary intake data from a digital behavior change weight loss program, which includes an interface for logging meals, beverages, and snacks, were an ...
DOI:
10.1016/j.numecd.2021.03.009

97. Advances in bioconversion of spent tea leaves to value-added products

Author:
Taru Negi; Yogesh Kumar; Ranjna Sirohi; Shikhangi Singh; Ayon Tarafdar; Sunil Pareek; Mukesh Kumar Awasthi; Narashans Alok Sagar
Source:
Bioresource technology 2022 v.346 pp. 126409
ISSN:
0960-8524
Subject:
anaerobic digestion; aspirin; batteries; biochar; biofuels; biopolymers; biotransformation; caffeine; catechin; dyes; fermentation; insulating materials; nanocatalysts; peptides; rutin; silage making; tea; theaflavins; theobromine; value added; vermicomposting; wastes
Abstract:
... Spent tea leaves (STL) are generated after the extraction of liquor from processed tea leaves and are regarded as an underutilized waste. STL are rich in essential amino acids, ω-6 and ω-3 fatty acids, alkaloids (theobromine and caffeine), polyphenols (catechin, theaflavins and rutin) and minerals (Ca, P, K, Mg, Mn) that could be utilized for the production of industrially important products. Verm ...
DOI:
10.1016/j.biortech.2021.126409

98. Aidi injection altered the activity of CYP2D4, CYP1A2, CYP2C19, CYP3A2, CYP2E1 and CYP2C11 in normal and diethylnitrosamine-induced hepatocellular carcinoma in rats

Author:
Yuan Lu; Yanli Wang; Yan He; Jie Pan; Yang Jin; Lin Zheng; Yong Huang; Yongjun Li; Wen Liu
Source:
Journal of ethnopharmacology 2022 v.286 no. pp. 114930
ISSN:
0378-8741
Subject:
Oriental traditional medicine; blood sampling; caffeine; caudal vein; cytochrome P-450; diethylnitrosamine; drug therapy; enzymes; hepatoma; liver; metabolism; tandem mass spectrometry; tolbutamide; ultra-performance liquid chromatography
Abstract:
... Aidi injection (ADI), a traditional Chinese medicine preparation, is widely used in combination with chemotherapy for the treatment of various malignant tumors, such as hepatocellular carcinoma (HCC). Studies have shown that changes in cytochrome P450 (CYP450) activity in disease states would affect the metabolism of drugs in vivo, especially liver diseases. However, the changes of Aidi injection ...
DOI:
10.1016/j.jep.2021.114930

99. Analytical method to monitor contaminants of emerging concern in water and soil samples from a non-conventional wastewater treatment system

Author:
Blanca Huidobro-López; Isabel López-Heras; Covadonga Alonso-Alonso; Virtudes Martínez-Hernández; Leonor Nozal; Irene de Bustamante
Source:
Journal of chromatography 2022 v.1671 pp. 463006
ISSN:
0021-9673
Subject:
acetaminophen; anticonvulsants; antihypertensive agents; aquifers; beta-adrenergic antagonists; caffeine; chemical species; electrospray ionization mass spectrometry; groundwater; lifestyle; lipids; liquid chromatography; soil; solid phase extraction; vegetation; wastewater; wastewater treatment
Abstract:
... Nonconventional wastewater treatments, such as vegetation filters (VFs), are propitious systems to attenuate contaminants of emerging concern (CECs) in small municipalities. The development of standardised multiresidue and multimatrix methods suitable for measuring a reliable number of CEC in environmental samples is crucial for monitoring infiltrating concentrations and for ensuring these systems ...
DOI:
10.1016/j.chroma.2022.463006

100. Androgenic haploid plant development via embryogenesis with simultaneous determination of bioactive metabolites in Cambod tea (Camellia assamica ssp. lasiocalyx)

Author:
Vijay Kumar Mishra; Ruchira Bajpai; Rakhi Chaturvedi
Source:
Plant cell, tissue, and organ culture 2022 v.148 no.3 pp. 515-531
ISSN:
0167-6857
Subject:
Camellia sinensis var. assamica; androgenesis; benzyladenine; caffeine; callus; cultivars; cytokinins; flow cytometry; genome; germination; glutamine; haploidy; homozygosity; metabolites; organ culture; plant development; plantlets; root tips; serine; sucrose; tea; theophylline
Abstract:
... This pioneering work reports successful androgenic plant development via embryogenesis from microspore calluses in anther cultures and estimation of bioactive metabolites in in vitro regenerants and parent plant (control) of Cambod tea, Camellia assamica ssp. lasiocalyx (Planch MS) cultivar TV19. Anthers bearing microspores at early-to-late uni-nucleate stage were selected to initiate androgenesis ...
DOI:
10.1007/s11240-021-02203-2