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You searched for: Subject calcitonin Remove constraint Subject: calcitonin Subject cyclic AMP Remove constraint Subject: cyclic AMP Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. Adrenomedullin: Continuing to explore cardioprotection

Author:
Toshihiro Tsuruda; Johji Kato; Kenji Kuwasako; Kazuo Kitamura
Source:
Peptides 2019 v.111 pp. 47-54
ISSN:
0196-9781
Subject:
aldosterone; amino acids; angiogenesis; apoptosis; biomarkers; calcitonin; cardioprotective effect; clinical trials; cyclic AMP; disulfide bonds; embryogenesis; gene transfer; half life; heart failure; humans; hypertrophy; myocardial infarction; myocardium; oxidative stress; rodents; secretion; therapeutics; vasodilation
Abstract:
... Adrenomedullin (AM), a peptide isolated from an extract of human pheochromocytoma, comprises 52 amino acids with an intramolecular disulfide bond and amidation at the carboxy-terminus. AM is present in various tissues and organs in rodents and humans, including the heart. The peptide concentration increases with cardiac hypertrophy, acute myocardial infarction, and overt heart failure in the plasm ...
DOI:
10.1016/j.peptides.2018.03.012

2. Mechanism of adrenomedullin 2/intermedin mediated vasorelaxation in rat main pulmonary artery

Author:
Gokcen Telli; Yasemin Erac; Banu Cahide Tel; Bulent Gumusel
Source:
Peptides 2018 v.103 pp. 65-71
ISSN:
0196-9781
Subject:
cAMP-dependent protein kinase; calcitonin; calcium; calcium channels; cell membranes; cyclic AMP; endothelial cells; endothelium; genes; glibenclamide; lanthanum; nitric oxide; potassium chloride; pulmonary artery; rats; vasodilation; verapamil
Abstract:
... Adrenomedullin 2/intermedin (AM2/IMD) is a member of calcitonin related gene peptide family and an important nitric oxide mediated vasorelaxant in various vascular beds. However, the mechanism of post receptor-interaction is not clear and may differ depending on tissue type and species. In this study, we aimed to investigate the exact mechanism and the role of BKCa and calcium channels on the vaso ...
DOI:
10.1016/j.peptides.2018.03.015

3. Receptor Activity Modifying Proteins Have Limited Effects on the Class B G Protein-Coupled Receptor Calcitonin Receptor-Like Receptor Stalk

Author:
Michael L. Garelja; Christina A. Walker; Andrew Siow; Sung H. Yang; Paul W.R. Harris; Margaret A. Brimble; Harriet A. Watkins; Joseph J. Gingell; Debbie L. Hay
Source:
Biochemistry 2018 v.57 no.8 pp. 1410-1422
ISSN:
1520-4995
Subject:
G-protein coupled receptors; alanine; calcitonin; calcitonin gene-related peptide; cyclic AMP; ligands; mutants; mutation
Abstract:
... The calcitonin receptor-like receptor (CLR) is a class B G protein-coupled receptor (GPCR) that forms the basis of three pharmacologically distinct receptors, the calcitonin gene-related peptide (CGRP) receptor, and two adrenomedullin (AM) receptors. These three receptors are created by CLR interacting with three receptor activity-modifying proteins (RAMPs). Class B GPCRs have an N-terminal extrac ...
DOI:
10.1021/acs.biochem.7b01180

4. Inhibitory effects of two G protein-coupled receptor kinases on the cell surface expression and signaling of the human adrenomedullin receptor

Author:
Kenji Kuwasako; Toshio Sekiguchi; Sayaka Nagata; Danfeng Jiang; Hidetaka Hayashi; Manabu Murakami; Yuichi Hattori; Kazuo Kitamura; Johji Kato
Source:
Biochemical and biophysical research communications 2016 v.470 pp. 894-899
ISSN:
0006-291X
Subject:
calcitonin; calcitonin receptors; cyclic AMP; flow cytometry; gene overexpression; humans; iodine; mutants; phosphotransferases (kinases)
Abstract:
... Receptor activity-modifying protein 2 (RAMP2) enables the calcitonin receptor-like receptor (CLR, a family B GPCR) to form the type 1 adrenomedullin receptor (AM1 receptor). Here, we investigated the effects of the five non-visual GPCR kinases (GRKs 2 through 6) on the cell surface expression of the human (h)AM1 receptor by cotransfecting each of these GRKs into HEK-293 cells that stably expressed ...
DOI:
10.1016/j.bbrc.2016.01.138

5. β-arrestins negatively control human adrenomedullin type 1-receptor internalization

Author:
Kenji Kuwasako; Kazuo Kitamura; Sayaka Nagata; Toshio Sekiguchi; Jiang Danfeng; Manabu Murakami; Yuichi Hattori; Johji Kato
Source:
Biochemical and biophysical research communications 2017 pp. -
ISSN:
0006-291X
Subject:
agonists; beta-2 adrenergic receptors; calcitonin; chimerism; clinical trials; cyclic AMP; flow cytometry; heart failure; humans; iodine; pain; protective effect
Abstract:
... Adrenomedullin (AM) is a potent hypotensive peptide that exerts a powerful variety of protective effects against multiorgan damage through the AM type 1 receptor (AM1 receptor), which consists of the calcitonin receptor-like receptor (CLR) and receptor activity-modifying protein 2 (RAMP2). Two β-arrestin (β-arr) isoforms, β-arr-1 and β-arr-2, play a central role in the agonist-induced internalizat ...
DOI:
10.1016/j.bbrc.2017.04.083

6. STC1 interference on calcitonin family of receptors signaling during osteoblastogenesis via adenylate cyclase inhibition

Author:
Silvia R. Terra; João Carlos R. Cardoso; Rute C. Félix; Leo Anderson M. Martins; Diogo Onofre G. Souza; Fatima C.R. Guma; Adelino Vicente M. Canário; Vanessa Schein
Source:
Molecular and Cellular Endocrinology 2015 v.403 pp. 78-87
ISSN:
0303-7207
Subject:
G-proteins; adenylate cyclase; bone formation; calcitonin; calcitonin gene-related peptide; calcitonin receptors; cyclic AMP; forskolin; gene expression; osteoblasts; plasma membrane
Abstract:
... Stanniocalcin 1 (STC1) and calcitonin gene-related peptide (CGRP) are involved in bone formation/remodeling. Here we investigate the effects of STC1 on functional heterodimer complex CALCRL/RAMP1, expression and activity during osteoblastogenesis. STC1 did not modify CALCRL and ramp1 gene expression during osteoblastogenesis when compared to controls. However, plasma membrane spatial distribution ...
DOI:
10.1016/j.mce.2015.01.010

7. Direct Peptide Bioconjugation/PEGylation at Tyrosine with Linear and Branched Polymeric Diazonium Salts

Author:
Jones Mathew W.; Mantovani Giuseppe; Blindauer Claudia A.; Ryan Sinead M.; Wang Xuexuan; Brayden David J.; Haddleton David M.
Source:
Journal of the American Chemical Society 2012 v.134 no.17 pp. 7406-7413
ISSN:
1520-5126
Subject:
animal models; breast neoplasms; calcitonin; calcium; chemical bonding; cyclic AMP; enkephalin; ethylene glycol; humans; in vitro studies; leucine; neoplasm cells; polyethylene glycol; polymerization; rats; receptors; salmon; salts; tyrosine
Abstract:
... Direct polymer conjugation at peptide tyrosine residues is described. In this study Tyr residues of both leucine enkephalin and salmon calcitonin (sCT) were targeted using appropriate diazonium salt-terminated linear monomethoxy poly(ethylene glycol)s (mPEGs) and poly(mPEG) methacrylate prepared by atom transfer radical polymerization. Judicious choice of the reaction conditionspH, stoichiometry, ...
DOI:
10.1021/ja211855q

8. The role of the ERK1/2 pathway as an alternative to the aging-diminished cyclic AMP pathway in calcitonin-mediated chondrogenesis in human nucleus pulposus

Author:
Wei-Hong Chen; Rong Zeng; Wen-Cheng Lo; Szu-Yu Tina Chen; Tung-Yuan Lai; David F. Williams; Win-Ping Deng
Source:
Biomaterials 2012 v.33 no.33 pp. 8256-8264
ISSN:
0142-9612
Subject:
calcitonin; calcitonin receptors; chondrogenesis; cyclic AMP; humans; phenotype; signal transduction; therapeutics
Abstract:
... Human disc degeneration initiated by aging in the central nucleus pulposus (hNP) is an irreversible process and the recovery has become seriously emerging. In this study, the related mechanisms of calcitonin on the regeneration of hNP and the effects of calcitonin on the age-related alterations were examined. The harvested hNP population was designated as YhNP (from young donor, age <50) and OhNP ...
DOI:
10.1016/j.biomaterials.2012.06.088

9. Structure–function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors

Author:
Tao Qi; Kien Ly; David R. Poyner; George Christopoulos; Patrick M. Sexton; Debbie L. Hay
Source:
Peptides 2011 v.32 no.5 pp. 1060-1067
ISSN:
0196-9781
Subject:
amino acid composition; amino acids; calcitonin; calcitonin gene-related peptide; calcitonin receptors; cyclic AMP; enzyme-linked immunosorbent assay; humans; mutants; pharmacology
Abstract:
... The receptors for calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are complexes of the calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMP). The CGRP receptor is a CLR/RAMP1 pairing whereas CLR/RAMP2 and CLR/RAMP3 constitute two subtypes of AM receptor: AM₁ and AM₂, respectively. Previous studies identified Glu74 in RAMP3 to be important for AM bin ...
DOI:
10.1016/j.peptides.2011.03.004

10. Structure–function analysis of helix 8 of human calcitonin receptor-like receptor within the adrenomedullin 1 receptor

Author:
Kenji Kuwasako; Kazuo Kitamura; Sayaka Nagata; Tomomi Hikosaka; Johji Kato
Source:
Peptides 2011 v.32 no.1 pp. 144-149
ISSN:
0196-9781
Subject:
G-protein coupled receptors; calcitonin; cyclic AMP; flow cytometry; humans; inhibitory concentration 50; mutants; mutation; structure-activity relationships
Abstract:
... Adrenomedullin 1 (AM₁) receptor is a heterodimer composed of calcitonin receptor-like receptor (CLR) – a family B G protein-coupled receptor (GPCR) – and receptor activity-modifying protein 2 (RAMP2). Both family A and family B GPCRs possess an eighth helix (helix 8) in the proximal portion of their C-terminal tails; however, little is known about the function of helix 8 in family B GPCRs. We ther ...
DOI:
10.1016/j.peptides.2010.10.005

11. ORIGINAL ARTICLE: The approach to the mechanism of calcitonin gene‐related peptide‐inducing inhibition of food intake

Author:
Sun, J.‐Y.; Jing, M.‐Y.; Wang, J.‐F.; Weng, X.‐Y.
Source:
Journal of animal physiology and animal nutrition 2010 v.94 no.5 pp. 552-560
ISSN:
0931-2439
Subject:
adenosine monophosphate; cAMP-dependent protein kinase; calcitonin; camping; cholecystokinin; correlation; cyclic AMP; food intake; gene expression regulation; genes; glucagon; insulin; intraperitoneal injection; leptin; messenger RNA; neuropeptide Y; rats
Abstract:
... The aim of this study was to investigate the anorectic mechanism of calcitonin gene‐related peptide (CGRP) in rats. Intraperitoneal injection of CGRP (50 μg/kg) resulted in decline (p < 0.05) in the food intake of rats at 0.5, 1, 2 and 4 h in comparison with saline control. Compared with saline‐treated group, the levels of hypothalamic 3′,5′‐cyclic adenosine monophosphate (cAMP) and plasma glucago ...
DOI:
10.1111/j.1439-0396.2009.00937.x
PubMed:
19906139

12. The role of small molecules in sperm capacitation

Author:
Fraser, L.R.
Source:
Theriogenology 2008 v.70 no.8 pp. 1356-1359
ISSN:
0093-691X
Subject:
adenosine; epinephrine; boars; cyclic AMP; acrosome reaction; fertilization (reproduction); adenylate cyclase; spermatozoa; calcitonin; seminal plasma; receptors
Abstract:
... Mammalian spermatozoa released into an appropriate environment in vitro can capacitate but then may undergo spontaneous acrosome reactions. Since successful sperm interaction with the zona pellucida of an unfertilized oocyte requires an intact sperm plasma membrane, spontaneous acrosome loss is biologically undesirable because it renders spermatozoa non-fertilizing. Several small molecules (fertil ...
DOI:
10.1016/j.theriogenology.2008.07.016
PubMed:
18775560