Subject: calcitonin and humans / Subject term: calcitonin receptors / Text availability: Citation in PubAg

Author:: Kenji Kuwasako; Toshio Sekiguchi; Sayaka Nagata; Danfeng Jiang; Hidetaka Hayashi; Manabu Murakami; Yuichi Hattori; Kazuo Kitamura; Johji Kato
Source:: Biochemical and biophysical research communications 2016 v.470 pp. 894-899
ISSN:: 0006-291X
Subject:: calcitonin; calcitonin receptors; cyclic AMP; flow cytometry; gene overexpression; humans; iodine; mutants; phosphotransferases (kinases)
Abstract:: ... Receptor activity-modifying protein 2 (RAMP2) enables the calcitonin receptor-like receptor (CLR, a family B GPCR) to form the type 1 adrenomedullin receptor (AM1 receptor). Here, we investigated the effects of the five non-visual GPCR kinases (GRKs 2 through 6) on the cell surface expression of the human (h)AM1 receptor by cotransfecting each of these GRKs into HEK-293 cells that stably expressed ...
DOI:: 10.1016/j.bbrc.2016.01.138
: https://doi.org/10.1016/j.bbrc.2016.01.138

Author:: Tao Qi; Kien Ly; David R. Poyner; George Christopoulos; Patrick M. Sexton; Debbie L. Hay
Source:: Peptides 2011 v.32 no.5 pp. 1060-1067
ISSN:: 0196-9781
Subject:: amino acid composition; amino acids; calcitonin; calcitonin gene-related peptide; calcitonin receptors; cyclic AMP; enzyme-linked immunosorbent assay; humans; mutants; pharmacology
Abstract:: ... The receptors for calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are complexes of the calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMP). The CGRP receptor is a CLR/RAMP1 pairing whereas CLR/RAMP2 and CLR/RAMP3 constitute two subtypes of AM receptor: AM₁ and AM₂, respectively. Previous studies identified Glu74 in RAMP3 to be important for AM bin ...
DOI:: 10.1016/j.peptides.2011.03.004
: https://doi.org/10.1016/j.peptides.2011.03.004

Author:: Nobuo Suzuki; Toshio Sekiguchi; Honoo Satake; Kanoko Kato; Yudai Nishiyama; Hideya Takahashi; Janine A. Danks; T. John Martin; Atsuhiko Hattori; Masaki Nakano; Makiko Kakikawa; Sotoshi Yamada; Maho Ogoshi; Susumu Hyodo; Yoko Yamaguchi; Vishwajit S. Chowdhury; Kazuichi Hayakawa; Hisayuki Funahashi; Tatsuya Sakamoto; Yuichi Sasayama
Source:: Gene 2012 v.499 no.2 pp. 326-331
ISSN:: 0378-1119
Subject:: Dasyatis; amino acids; animal ovaries; brain; calcitonin; calcitonin receptors; calcium; cartilage; complementary DNA; euryhaline species; flounder; frogs; gall bladder; humans; kidneys; liver; messenger RNA; metabolism; open reading frames; osmoregulation; pancreas; phylogeny; pituitary gland; seawater; spleen; testes
Abstract:: ... In cartilaginous fish, two cDNAs encoding calcitonin-family receptors were isolated for the first time from the stingray brain. The open reading frame of one receptor cDNA coded a 525-amino acid protein. The amino acid identity of this receptor to human calcitonin-receptor-like receptor (CRLR) is 64.5%, frog CRLR is 64.7%, and flounder CRLR is 61.2% and this was higher than to human calcitonin rec ...
DOI:: 10.1016/j.gene.2012.03.042
PubMed:: 22429839
: https://doi.org/10.1016/j.gene.2012.03.042

Author:: Wei-Hong Chen; Rong Zeng; Wen-Cheng Lo; Szu-Yu Tina Chen; Tung-Yuan Lai; David F. Williams; Win-Ping Deng
Source:: Biomaterials 2012 v.33 no.33 pp. 8256-8264
ISSN:: 0142-9612
Subject:: calcitonin; calcitonin receptors; chondrogenesis; cyclic AMP; humans; phenotype; signal transduction; therapeutics
Abstract:: ... Human disc degeneration initiated by aging in the central nucleus pulposus (hNP) is an irreversible process and the recovery has become seriously emerging. In this study, the related mechanisms of calcitonin on the regeneration of hNP and the effects of calcitonin on the age-related alterations were examined. The harvested hNP population was designated as YhNP (from young donor, age <50) and OhNP ...
DOI:: 10.1016/j.biomaterials.2012.06.088
: https://doi.org/10.1016/j.biomaterials.2012.06.088

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