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1. Anti-nociceptive effects of ECa 233 a standardized extract of Centella asiatica (L.) Urban on chronic neuropathic orofacial pain in mice

Author:
Ananya Buapratoom; Aree Wanasuntronwong; Onrawee Khongsombat; Mayuree H. Tantisira
Source:
Journal of ethnopharmacology 2022 v.283 pp. 114737
ISSN:
0378-8741
Subject:
Centella asiatica; Parkinson disease; analgesic effect; calcitonin; clinical trials; cognition; ganglia; locomotion; mechanism of action; nerve tissue; pain; pharmacokinetics; sedatives; somatosensory disorders; synergism; toxicity; traditional medicine
Abstract:
... ECa 233 is a standardized extract of Centella asiatica (L.) Urban, a herb traditionally used to treat a number of diseases including neurological disorders. Accordingly, ECa 233 showed benefits on animal models of cognitive deficits, chronic stress and Parkinson's disease. Analgesic activity of ECa 233 was shown in Tail's flick test in rodent and relieving aphthous ulcer pain in man. Moreover, acu ...
DOI:
10.1016/j.jep.2021.114737

2. Cannabidiol improves thyroid function via modulating vitamin D3 receptor in vitamin D3 deficiency diet-induced rat model

Author:
Mahendra Kumar Trivedi; Sambhu Mondal; Snehasis Jana
Source:
Journal of food science and technology 2022 v.59 no.8 pp. 3237-3244
ISSN:
0022-1155
Subject:
animal models; biomarkers; blood serum; bone health; calcitonin; calcitriol receptors; cannabidiol; cholecalciferol; diet; food science; hypothyroidism; kidneys; liver; metabolites; parathyroid hormone; technology; thyroid function; thyrotropin; thyroxine
Abstract:
... The study was evaluated the impact of cannabidiol (CBD) on thyroid hormones by modulation cannabinoid receptor-2 (CB2) and vitamin D receptor (VDR) in rats fed with vitamin D₃ deficiency diet (VDD). CB2-receptors were analyzed by RT-PCR method and others biomarkers by ELISA. The relative expression of CB2 (thyroid ~ 4 folds), VDR protein (liver, 151.72%), and (kidney, 66%) was significantly increa ...
DOI:
10.1007/s13197-022-05492-3

3. Dietary protein levels during the pullet phase (8–18 week) influence the mortality during laying stage

Author:
C.T. Oluwabiyi; J. Zhao; H. Jiao; X. Wang; H. Lin
Source:
Journal of applied poultry research 2022 v.31 no.1 pp. 100223
ISSN:
1056-6171
Subject:
blood serum; body composition; body weight; calcitonin; crude protein; dietary protein; egg production; egg quality; feed intake; femur; growth performance; high protein diet; low protein diet; mortality; nutritional intervention; pullets; research; tibia
Abstract:
... An experiment was conducted to evaluate the effects of dietary crude protein levels on growth performance, serum and bone parameters, production performance, and egg quality of Hy-Line brown chicken. A total of 384 pullets were randomly allotted to one of 3 groups with 8 replicates of 16 birds each and were fed with a diet containing 14% crude protein (CP), 16% CP, or 18% CP from 8 to 18 wk. At 18 ...
DOI:
10.1016/j.japr.2021.100223

4. Effects of calcium propionate on milk performance and serum metabolome of dairy cows in early lactation

Author:
Fan Zhang; Yiguang Zhao; Yue Wang; Hui Wang; Yuming Guo; Benhai Xiong
Source:
Animal feed science and technology 2022 v.283 pp. 115185
ISSN:
0377-8401
Subject:
Holstein; alanine transaminase; alkaline phosphatase; antioxidant activity; aspartate transaminase; bile; bile acids; blood glucose; blood serum; calcitonin; calcitriol; calcium; calcium propionate; catalase; early lactation; energy balance; feeds; free fatty acids; glucagon; glutathione peroxidase; hypocalcemia; insulin; magnesium; malondialdehyde; metabolism; metabolome; metabolomics; milk; milk composition; milk yield; parathyroid hormone; superoxide dismutase; technology
Abstract:
... Calcium propionate is a source of energy and calcium for alleviating negative energy balance and hypocalcemia. The objective of this study was to investigate changes in milk composition and serum metabolites associated with calcium propionate fed to postpartum dairy cows for 5 weeks. Thirty-two multiparous Holstein cows after calving were randomly allocated to control (CON), low calcium propionate ...
DOI:
10.1016/j.anifeedsci.2021.115185

5. Hyaluronic acid-g-PPG and PEG-PPG-PEG hybrid thermogel for prolonged gel stability and sustained drug release

Author:
Soyeon Kim; Hyun Jung Lee; Byeongmoon Jeong
Source:
Carbohydrate polymers 2022 v.291 pp. 119559
ISSN:
0144-8617
Subject:
calcitonin; carbohydrates; crosslinking; drugs; gels; hydrophobicity; propylene glycol; rheology; temperature
Abstract:
... Hyaluronic acid-graft-poly(propylene glycol) (HA-g-PPG) was prepared to induce hydrophobic interactions between HA-g-PPG and F127 PPGs (poly(ethylene glycol)-poly(propylene glycol)-poly(ethylene glycol)) and consequent increases in gel stability of F127 gel. Molecular weights of 340, 1000, and 2500 Da were used for PPG, and grafting ratios of HA-g-PPG varied over 3%, 12%, and 50%. Using rheology m ...
DOI:
10.1016/j.carbpol.2022.119559

6. Neuropeptides in Rhipicephalus microplus and other hard ticks

Author:
Jéssica Waldman; Marina Amaral Xavier; Larissa Rezende Vieira; Raquel Logullo; Gloria Regina Cardoso Braz; Lucas Tirloni; José Marcos C. Ribeiro; Jan A. Veenstra; Itabajara da Silva Vaz
Source:
Ticks and tick-borne diseases 2022 v.13 no.3 pp. 101910
ISSN:
1877-959X
Subject:
Rhipicephalus microplus; allatotropin; calcitonin; central nervous system; computer simulation; drugs; eclosion hormone; fat body; glycoproteins; metabolism; midgut; neurohormones; neurotransmitters; oxidants; prediction; pyrokinin; relaxin; ticks; transcriptome
Abstract:
... The synganglion is the central nervous system of ticks and, as such, controls tick physiology. It does so through the production and release of signaling molecules, many of which are neuropeptides. These peptides can function as neurotransmitters, neuromodulators and/or neurohormones, although in most cases their functions remain to be established. We identified and performed in silico characteriz ...
DOI:
10.1016/j.ttbdis.2022.101910

7. Peptides in the regulation of glucagon secretion

Author:
Daniel B. Andersen; Jens J. Holst
Source:
Peptides 2022 v.148 pp. 170683
ISSN:
0196-9781
Subject:
appetite; arginine vasopressin; blood glucose; calcitonin; fasting; gastric inhibitory polypeptide; ghrelin; glucagon; glucagon-like peptide 1; glucose; glycemic control; glycogen; homeostasis; hyperglycemia; hypoglycemia; insulin; liver; neurons; neurotensin; oxytocin; pancreatic polypeptide; somatostatin; stomach; tyrosine
Abstract:
... Glucose homeostasis is maintained by the glucoregulatory hormones, glucagon, insulin and somatostatin, secreted from the islets of Langerhans. Glucagon is the body’s most important anti-hypoglycemic hormone, mobilizing glucose from glycogen stores in the liver in response to fasting, thus maintaining plasma glucose levels within healthy limits. Glucagon secretion is regulated by both circulating n ...
DOI:
10.1016/j.peptides.2021.170683

8. Procalcitonin mediates vascular dysfunction in obesity

Author:
Laura Brabenec; Katharina E.M. Hellenthal; Melanie Müller; Sebastian Kintrup; Finnja Zurek-Leffers; Marina Kardell; Mandy Otto; Nana-Maria Wagner
Source:
Life sciences 2022 v.307 pp. 120889
ISSN:
0024-3205
Subject:
Western blotting; adipose tissue; antagonists; calcitonin; calcitonin gene-related peptide; comorbidity; inflammation; intravenous injection; magnetism; mice; nitric oxide; obesity; reactive oxygen species; vasodilation
Abstract:
... Obesity is accompanied by a chronic low-grade inflammation associated with endothelial dysfunction and vascular complications. Procalcitonin is a marker of inflammation, secreted by adipose tissue and elevated in obese subjects. We here investigated whether visceral or perivascular fat-derived procalcitonin is a target to improve obesity-induced endothelial dysfunction. Procalcitonin expression wa ...
DOI:
10.1016/j.lfs.2022.120889

9. Serum bone metabolism biomarkers in healthy filies and colts from weaning until one year of age

Author:
Francesca Arfuso; Anna Assenza; Francesco Tosto; Claudia Giannetto; Claudia Interlandi; Giuseppe Piccione; Luigi Liotta
Source:
Research in veterinary science 2022 v.150 pp. 156-163
ISSN:
0034-5288
Subject:
acid phosphatase; alkaline phosphatase; analysis of variance; biomarkers; blood serum; bone metabolism; calcitonin; calcium; foals; metabolism; osteocalcin; parathyroid hormone; phosphorus; puberty; research; veterinary medicine
Abstract:
... This study aimed to investigate the serum concentration of osteocalcin (OC), parathyroid hormone (PTH), calcitonin (CT), calcium (Ca), phosphorus (P), alkaline phosphatase (ALP) and acid phosphatase (AP) in healthy-weaned-foals from 8 months of age until the first year of life. Moreover, the correlation of investigated parameters and foals' age, as well as the relationship between the serum values ...
DOI:
10.1016/j.rvsc.2022.06.018

10. Vacuolal and Peroxisomal Calcium Ion Transporters in Yeasts and Fungi: Key Role in the Translocation of Intermediates in the Biosynthesis of Fungal Metabolites

Author:
Juan F. Martín
Source:
Genes 2022 v.13 no.8 pp. -
ISSN:
2073-4425
Subject:
Acremonium chrysogenum; Penicillium chrysogenum; biosynthesis; calcitonin; calcium; gene expression; models; penicillin N; peroxisomes; secondary metabolites; signal transduction; tripeptides; vacuoles; yeasts
Abstract:
... The intracellular calcium content in fungal cells is influenced by a large number of environmental and nutritional factors. Sharp changes in the cytosolic calcium level act as signals that are decoded by the cell gene expression machinery, resulting in several physiological responses, including differentiation and secondary metabolites biosynthesis. Expression of the three penicillin biosynthetic ...
DOI:
10.3390/genes13081450

11. Abnormal Bone Metabolism May Be a Primary Causative Factor of Keel Bone Fractures in Laying Hens

Author:
Haidong Wei; Yanqing Chen; Haoyang Nian; Jing Wang; Yilin Liu; Jianxing Wang; Kaiqi Yang; Qian Zhao; Runxiang Zhang; Jun Bao
Source:
Animals 2021 v.11 no.11 pp. -
ISSN:
2076-2615
Subject:
X-radiation; acid phosphatase; alkaline phosphatase; blood serum; body weight; bone metabolism; cages; calcitonin; corticosterone; egg quality; eosin; keel bone; metabolism; osteoblasts; osteocalcin; osteoclasts; parathyroid hormone
Abstract:
... Keel bone damage negatively affects the welfare, production performance, egg quality, and mobility of laying hens. This study aimed to investigate whether abnormal bone metabolism causes keel bone damage in laying hens. Eighty Hy-line Brown laying hens were housed in eight furnished cages with 10 birds per cage and studied from 18 to 29 weeks of age (WOA). Accordingly, keel bone status was assesse ...
DOI:
10.3390/ani11113133

12. Dietary calcium requirement of red swamp crayfish (Procambarus clarkia)

Author:
Lei Xu; Juan Tian; Hua Wen; Fan Wu; Wenbing Zhang; Weihua Gao; Xiaoru Chen
Source:
Aquaculture nutrition 2021 v.27 no.1 pp. 153-162
ISSN:
1353-5773
Subject:
Procambarus clarkii; alkaline phosphatase; amylases; aquaculture; blood serum; body weight; calcitonin; calcium; carboxylic ester hydrolases; crayfish; dietary calcium; exoskeleton; feed conversion; hepatopancreas; inorganic phosphorus; intestines; muscles; parathyroid hormone; phosphorus content; proteinases; weight gain
Abstract:
... To investigate dietary calcium requirement of red swamp crayfish (Procambarus clarkia), six semi‐purified diets were formulated to contain different concentrations of calcium (2.7(control group), 6.1, 11.9, 17.6, 23.5 and 29.1 g/kg calcium). Each diet was hand‐fed to triplicate of 15 crayfish with average initial body weight (6.22 ± 0.87) g for 8 weeks. The results showed that weight gain rate (WG ...
DOI:
10.1111/anu.13173

13. Dietary phosphorus restriction affects bone metabolism, vitamin D metabolism and rumen fermentation traits in sheep

Author:
Oriana M. Köhler; Walter Grünberg; Nadine Schnepel; Alexandra S. Muscher‐Banse; Abbas Rajaeerad; Jürgen Hummel; Gerhard Breves; Mirja R. Wilkens
Source:
Journal of animal physiology and animal nutrition 2021 v.105 no.1 pp. 35-50
ISSN:
0931-2439
Subject:
RNA; absorption; ammonia; animal nutrition; blood serum; bone metabolism; bones; butyrates; calcitonin; calcitriol; calcium; digestive tract; females; fermentation; fibroblast growth factors; gene expression; homeostasis; kidneys; mutton; parathyroid hormone; parotid gland; phosphates; phosphorus; resorption; rumen fermentation; saliva; sheep
Abstract:
... Homeostasis of calcium (Ca) and phosphate (Pᵢ) is maintained by a concerted interplay of absorption and reabsorption via the gastrointestinal tract and the kidney and by storage and mobilization from the bone regulated mainly by parathyroid hormone (PTH), 1,25‐dihydroxycholecalciferol and calcitonin. The present study aimed at characterizing the effects of dietary P restriction on bone, vitamin D ...
DOI:
10.1111/jpn.13449

14. Effect of Chemically-Induced Diabetes Mellitus on Phenotypic Variability of the Enteric Neurons in the Descending Colon in the Pig

Author:
Michał Bulc; Jarosław Całka; Łukasz Zielonka; Michał Dąbrowski; Katarzyna Palus
Source:
Annals of animal science 2021 v.21 no.4 pp. 1403-1422
ISSN:
2300-8733
Subject:
animal science; calcitonin; cocaine; colon; diabetes mellitus; digestive tract; hyperglycemia; neurotransmitters; peripheral nervous system diseases; phenotypic variation; swine; vasoactive intestinal peptide
Abstract:
... Gastrointestinal neuropathy in diabetes is one of numerous diseases resulting in abnormal functioning of the gastrointestinal tract (GIT), and it may affect any section of the GIT, including the descending colon. In the gastrointestinal system, the neurons are arranged in an interconnecting network defined as the enteric nervous system (ENS) which includes the myenteric plexus and the submucosal p ...
DOI:
10.2478/aoas-2020-0121

15. Effect of azomite on growth performance, nutrient utilization, serum biochemical index and bone mineralization of broilers fed low protein diet

Author:
Shoaib Ahmed Pirzado; Faiz ul Hassan; Muhammad Asif Arain; Wu Zhengke; Cai Huiyi; Tesfay Hagos Haile; Liu Guohua
Source:
Italian journal of animal science 2021 v.20 no.1 pp. 1282-1291
ISSN:
1828-051X
Subject:
abdominal fat; average daily gain; blood serum; body weight; bone mineralization; breast muscle; broiler chickens; calcitonin; calcium; creatinine; crude protein; dietary supplements; digestibility; feed conversion; feed intake; growth performance; low protein diet; males; metabolizable energy; mineralization; phosphorus; somatotropin; tibia; trypsin
Abstract:
... The present study investigated the effect of Azomite (AZO) on the growth performance, nutrient utilisation, and bone mineralisation of broilers fed low protein diet. A total number of 180 one-day-old male chicks were randomly distributed to three treatment groups having six replicates of 10 birds each. Experimental diets included; positive control (PC) with 21.5% CP (starter) and 19.0% CP (finishe ...
DOI:
10.1080/1828051X.2021.1953409

16. Experimental study on renoprotective effect of intermedin on diabetic nephropathy

Author:
Yanhong Wang; Jihua Tian; Yang Mi; Xiaojun Ren; Shizhong Lian; Jing Kang; Juanjuan Wang; Haojing Zang; Zhijing Wu; Jia Yang; Xi Qiao; Xiaoshuang Zhou; Guiqin Wang; Yun Zhou; Rongshan Li
Source:
Molecular and cellular endocrinology 2021 v.528 pp. 111224
ISSN:
0303-7207
Subject:
actin; antioxidants; apoptosis; calcitonin; calcitonin gene-related peptide; caspase-3; diabetic nephropathy; diaphragm; endoplasmic reticulum; glucose; protein deficiencies; proteinuria; renoprotective effect; streptozotocin; ultrastructure; unfolded protein response
Abstract:
... Intermedin(IMD) is a novel member of the calcitonin/calcitonin gene-related peptide (CT/CGRP) family that has anti-inflammatory, antioxidant and anti-apoptosis properties. This study aimed to evaluate the renoprotective effects of IMD on podocyte apoptotic loss and slit diaphragm protein deficiency the kidneys of rats with in streptozotocin (STZ) induced diabetes in high glucose-exposed podocytes. ...
DOI:
10.1016/j.mce.2021.111224

17. A Histochemical and Immunohistochemical Study on The Thyroid Gland of Dromedary Camel (Camelus dromedarius)

Author:
Devendra Singh; Sanjeev Joshi; Pankaj Kumar Thanvi; Aruna Panwar; Om Prakash Choudhary
Source:
Journal of camel practice and research 2021 v.28 no.3 pp. 303-311
ISSN:
2277-8934
Subject:
Camelus dromedarius; antibodies; calcitonin; calcium; camels; carcinoma; epithelium; glycogen; glycosaminoglycans; immunohistochemistry; iron; nucleic acids; research; thyroid gland
Abstract:
... The present study was designed to provide the histochemical and immunohistochemical features of the thyroid gland in dromedary camel. The thyroid glands were collected from naturally dead camels (n=16) of both sexes. Different thyroid gland regions showed positive reactions in different intensities with different histochemical stains for sulphated mucopolysaccharides, polysaccharides, calcium, iro ...
DOI:
10.5958/2277-8934.2021.00047.3

18. Hydrogen sulfide inhibits calcium and phosphorus loss after fracture by negatively regulating glucocorticoid/glucocorticoid receptor α

Author:
Feng Liao; Zongdong Zhu; Chengwei Xiao; Jiabin Yuan; Bin Geng; Jiang Hu
Source:
Life sciences 2021 v.274 pp. 119363
ISSN:
0024-3205
Subject:
acid phosphatase; alkaline phosphatase; aminooxyacetic acid; blood serum; bone metabolism; calcitonin; calcium; collagen; colorimetry; excretion; femur; fibroblast growth factors; glucocorticoid receptors; glucocorticoids; hydrogen sulfide; kidneys; metabolism; parathyroid hormone; phosphorus; precipitin tests; sodium phosphate; symporters
Abstract:
... Post-fracture calcium and phosphorus excretion is greater than influx, which might be caused by stress. Glucocorticoid is known to enhance calcium and phosphorous excretion, and hydrogen sulfide (H₂S) has been shown to exert inhibitory effects on glucocorticoid. Therefore, this study explored whether H₂S could inhibit calcium and phosphorus loss after fracture by regulating glucocorticoid and/or i ...
DOI:
10.1016/j.lfs.2021.119363

19. Identification and validation of CALCRL-associated prognostic genes in acute myeloid leukemia

Author:
Zineng Huang; Huifang Zhang; Cheng Xing; Lei Zhang; Hongkai Zhu; Zeyu Deng; Le Yin; En Dong; Canfei Wang; Hongling Peng
Source:
Gene 2022 v.809 pp. 146009
ISSN:
0378-1119
Subject:
calcitonin; data collection; databases; drug resistance; drug therapy; gene expression; genes; myeloid leukemia; prognosis; relapse; survival rate
Abstract:
... In the past few decades, several advances have been made in the field of acute myeloid leukemia (AML), especially in the development of novel drugs. However, the overall survival rate remains particularly disappointing due to a high rate of chemotherapy resistance and relapse. The calcitonin receptor-like receptor (CALCRL) is a novel promising therapeutic target of AML and has been indicated to be ...
DOI:
10.1016/j.gene.2021.146009

20. Identification of cells expressing Calcitonins A and B, PDF and ACP in Locusta migratoria using cross-reacting antisera and in situ hybridization

Author:
Jan A. Veenstra
Source:
Peptides 2021 v.146 pp. 170667
ISSN:
0196-9781
Subject:
Locusta migratoria; antiserum; brain; calcitonin; cecum; dipeptides; disulfide bonds; diuretic hormone; electrocoagulation; guinea pigs; hybridization; midgut; rabbits
Abstract:
... This work was initiated because an old publication suggested that electrocoagulation of four paraldehyde fuchsin positive cells in the brain of Locusta migratoria might produce a diuretic hormone, the identity of which remains unknown, since none of the antisera to the various putative Locusta diuretic hormones recognizes these cells. The paraldehyde fuchsin positive staining suggests a peptide wi ...
DOI:
10.1016/j.peptides.2021.170667

21. Lycopene ameliorates the effect of Aroclor 1254 on morphology, proliferation, and angiogenesis of the thyroid gland in rat

Author:
Marwa A.A. Ibrahim; Heba H. Elkaliny; Marwa M. Abd-Elsalam
Source:
Toxicology 2021 v.452 pp. 152722
ISSN:
0300-483X
Subject:
adults; albino; angiogenesis; antioxidants; aroclors; blood serum; calcitonin; eosin; fibrosis; homeostasis; immunohistochemistry; inflammation; lycopene; males; malondialdehyde; rats; thyroid gland; thyrotropin; toxicology
Abstract:
... Aroclor 1254 is a mixture of polychlorinated biphenyls that are reported to disrupt thyroid hormone homeostasis, yet little is known on its effect on thyroid gland microarchitecture. Lycopene is a commonly used potent antioxidant. This study is a biochemical, histological, and immunohistochemical assessment of the effect of Aroclor 1254 on the morphology, proliferation, and angiogenesis of the thy ...
DOI:
10.1016/j.tox.2021.152722

22. Octreotide and pasireotide effects on medullary thyroid carcinoma (MTC) cells growth, migration and invasion

Author:
E. Giardino; R. Catalano; F. Mangili; A.M. Barbieri; D. Treppiedi; F.M. Elli; A. Dolci; A. Contarino; A. Spada; M. Arosio; G. Mantovani; E. Peverelli
Source:
Molecular and cellular endocrinology 2021 v.520 pp. 111092
ISSN:
0303-7207
Subject:
apoptosis; calcitonin; carcinoma; cell cycle; cell lines; cell movement; cell proliferation; cyclins; octreotide; phosphorylation; somatostatin
Abstract:
... Medullary thyroid carcinoma (MTC) is a rare neuroendocrine neoplasm of the parafollicular thyroid C cells. Although somatostatin receptors are expressed by MTCs, treatment with octreotide has shown poor efficacy, whereas recently pasireotide has demonstrated antiproliferative effects in persistent postoperative MTCs.Aim of this study was to test the effects of octreotide and pasireotide on MTC cel ...
DOI:
10.1016/j.mce.2020.111092

23. One-step-immunoassay of procalcitonin enables rapid and accurate diagnosis of bacterial infection

Author:
Jae-Hwan Oh; Jung-Hyuk Kwon; Hye-Hyun Kim; Jeewon Lee
Source:
RSC advances 2021 v.11 no.35 pp. 21375-21383
ISSN:
2046-2069
Subject:
Hepatitis B virus; bacterial infections; biomarkers; blood; bovine serum albumin; calcitonin; capsid; chemiluminescence; detection limit; early diagnosis; gold; immunoassays; microparticles; nanogold; nickel; patients; staphylococcal protein A
Abstract:
... Procalcitonin (PCT) (i.e. a precursor of calcitonin) attracts much attention as a reliable biomarker of bacterial infections because its concentration increases rapidly in the blood when bacterial infections occur in the body. Sepsis may occur due to indiscriminate and vigorous proliferation of infectious bacteria, and accordingly early diagnosis and treatment of bacterial infection are of crucial ...
DOI:
10.1039/d1ra02494a

24. Peptide ligand interaction with maltose-binding protein tagged to the calcitonin gene-related peptide receptor: The inhibitory role of receptor N-glycosylation

Author:
Sangmin Lee
Source:
Peptides 2022 v.150 pp. 170735
ISSN:
0196-9781
Subject:
blood pressure; calcitonin; calcitonin gene-related peptide; crystallization; glycosylation; ligands; migraine; peptide receptors
Abstract:
... Calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are peptide hormones and their receptors play a critical role in migraine progression and blood pressure control, respectively. CGRP and AM receptors are structurally related since they are the complex of the calcitonin receptor-like receptor (CLR) with the different types of receptor activity-modifying protein (RAMP). Several crystal ...
DOI:
10.1016/j.peptides.2022.170735

25. Screen of anti-migraine active compounds from Duijinsan by spectrum-effect relationship analysis and molecular docking

Author:
Guo Zheng; Lu Gan; Li-Ying Jia; De-Cui Zhou; Sheng Bi; Zhao-Qing Meng; Gui-Ju Guan; Meng-Meng Huang; Xin He; Chun-Feng Zhang; Chong-Zhi Wang; Chun-Su Yuan
Source:
Journal of ethnopharmacology 2021 v.279 pp. 114352
ISSN:
0378-8741
Subject:
Oriental traditional medicine; baicalin; calcitonin; chrysin; genes; high performance liquid chromatography; inflammation; nerve tissue; neurons; transient receptor potential vanilloid channels
Abstract:
... Duijinsan (DJS) is a famous Chinese medicine prescription composed of Radix scutellariae (RS) and Rhei Radix (RRR), which has been mainly used for treating migraine.This study aimed to uncover the anti-migraine active compounds from DJS and preliminary predicted the pharmacological mechanism by evaluating the spectrum-effect relationship between high-performance liquid chromatography (HPLC) finger ...
DOI:
10.1016/j.jep.2021.114352

26. Study on the morphological and metabolic changes of femur in laying hens with hypophosphatemia

Author:
Naixi Yang; Dongliu Luo; Xiangqi Teng; Zhihui Liu; Haibin Wang; Ming Ge; Ruili Zhang
Source:
Research in veterinary science 2021 v.134 pp. 127-136
ISSN:
0034-5288
Subject:
biomechanics; blood serum; body weight; bone density; calcitonin; calcium; cortex; diet; egg quality; estradiol; femur; histopathology; homeostasis; ligands; osteocalcin; phosphorus; phosphorus content; protein synthesis; research; veterinary medicine
Abstract:
... Layer fatigue syndrome caused by the lack of calcium and phosphorus can cause fracture in laying hens. The effect of phosphorus deficiency on the femur of laying hens with layer fatigue syndrome has not been studied. In this study, sixty 22-week-old Roman white layers were randomly divided into control group (group C) and low phosphorus group (group P), 30 individuals in each group. The available ...
DOI:
10.1016/j.rvsc.2020.12.004

27. Tyrosine 12 of human calcitonin modulates its amyloid formation, membrane binding, and bioactivity

Author:
I-Ching Hsieh; Ting-Wei Chen; Ya-Ping Chuang; Yun-Ju Lai; Ling-Hsien Tu
Source:
Biochimie 2022 v.197 pp. 121-129
ISSN:
0300-9084
Subject:
amyloid; bioactive properties; bioavailability; blood; calcitonin; calcium; computer software; drugs; humans; osteoporosis; prediction; therapeutics; tyrosine
Abstract:
... Irreversible aggregation greatly limits the bioavailability and therapeutic activity of peptide-based drugs, so preventing protein or peptide aggregation is a common issue in drug formulation. Human calcitonin (hCT), a peptide hormone secreted by thyroidal parafollicular cells, can regulate blood calcium levels and maintain bone structure. Hence, it can be used as a treatment for metabolic bone di ...
DOI:
10.1016/j.biochi.2022.02.007

28. Understanding Transcriptomic and Serological Differences between Forced Molting and Natural Molting in Laying Hens

Author:
Tongyu Zhang; Zhonghua Ning; Yu Chen; Junhui Wen; Yaxiong Jia; Liang Wang; Xueze Lv; Weifang Yang; Changqing Qu; Haiying Li; Huie Wang; Lujiang Qu
Source:
Genes 2021 v.13 no.1 pp. -
ISSN:
2073-4425
Subject:
calcitonin; climate change; disease resistance; egg production; hypothalamus; somatotropin; thyroxine; transcriptome; transcriptomics
Abstract:
... Molting is natural adaptation to climate change in all birds, including chickens. Forced molting (FM) can rejuvenate and reactivate the reproductive potential of aged hens, but the effect of natural molting (NM) on older chickens is not clear. To explore why FM has a dramatically different effect on chickens compared with NM, the transcriptome analyses of the hypothalamus and ovary in forced molte ...
DOI:
10.3390/genes13010089

29. A feline-focused review of chronic kidney disease-mineral and bone disorders — Part 1: Physiology of calcium handling

Author:
Pak-Kan Tang; Rebecca F. Geddes; Rosanne E. Jepson; Jonathan Elliott
Source:
veterinary journal 2021 v.275 pp. 105719
ISSN:
1090-0233
Subject:
calcitonin; calcitriol; calcium; calcium receptors; fibroblast growth factors; homeostasis; kidney diseases; kidneys; metabolism; parathyroid hormone; pathophysiology; phosphorus
Abstract:
... Mineral derangements are a common consequence of chronic kidney disease (CKD). Despite the well-established role of phosphorus in the pathophysiology of CKD, the implications of calcium disturbances associated with CKD remain equivocal. Calcium plays an essential role in numerous physiological functions in the body and is a fundamental structural component of bone. An understanding of calcium meta ...
DOI:
10.1016/j.tvjl.2021.105719

30. Amylin brain circuitry

Author:
Lavinia Boccia; Salome Gamakharia; Bernd Coester; Lynda Whiting; Thomas A. Lutz; Christelle Le Foll
Source:
Peptides 2020 v.132 pp. 170366
ISSN:
0196-9781
Subject:
agonists; amygdala; binding properties; binding sites; biochemical pathways; calcitonin; energy expenditure; glucose; homeostasis; hypothalamus; ingestion; islets of Langerhans; locomotion; metabolism; neurons; salmon
Abstract:
... Amylin is a peptide hormone that is mainly known to be produced by pancreatic β-cells in response to a meal but amylin is also produced by brain cells in discrete brain areas albeit in a lesser amount. Amylin receptor (AMY) is composed of the calcitonin core-receptor (CTR) and one of the 3 receptor activity modifying protein (RAMP), thus forming AMY1−3; RAMP enhances amylin binding properties to t ...
DOI:
10.1016/j.peptides.2020.170366

31. Construction of calcitonin gene-related peptide-modified mesenchymal stem cells and analysis of their effects on the migration and proliferation of vascular smooth muscle cells

Author:
Panke Chen; Fang He; Tao Liu; Shuai Ma; Bei Shi
Source:
In vitro cellular & developmental biology 2020 v.56 no.2 pp. 181-191
ISSN:
1071-2690
Subject:
Lentivirus; beta-galactosidase; bone marrow; calcitonin; calcitonin gene-related peptide; cell proliferation; coculture; enzyme-linked immunosorbent assay; flow cytometry; fluorescence microscopy; fluorescent antibody technique; genes; genetic vectors; mesenchymal stromal cells; messenger RNA; myocytes; protein secretion; quantitative polymerase chain reaction; rats; smooth muscle; staining; toxicity testing; transfection
Abstract:
... Lentiviral expression vectors for calcitonin gene-related peptide (CGRP) were used to transfect rat bone marrow mesenchymal stem cells (MSCs). After assessing the biological characteristics of proliferation and aging in MSCs transfected with CGRP, we observed the effects of the CGRP-modified rat MSCs on the migration and proliferation of rat vascular smooth muscle cells (VSMCs) in vitro. Rat MSCs ...
DOI:
10.1007/s11626-019-00429-1

32. Effects of Premating Calcium and Phosphorus Supplementation on Reproduction Efficiency of Grazing Yak Heifers

Author:
Jia Zhou; Jianxun Zhang; Benchu Xue; Shuangming Yue; Chao Yang; Bai Xue
Source:
Animals 2021 v.11 no.2 pp. -
ISSN:
2076-2615
Subject:
alkaline phosphatase; average daily gain; biomarkers; blood serum; body condition; body weight changes; bone metabolism; calcitonin; calcium; calcium chloride; conception rate; hydroxyproline; monocalcium phosphate; osteocalcin; phosphorus; reproductive efficiency; yaks; China
Abstract:
... Reproductive efficiency is the main factor limiting yak production on the Tibet Plateau. The purpose of this study was to investigate the effect of supplementation with calcium chloride (CaCl) and monocalcium phosphate (MCP) for 30 days before breeding on body weight (BW) change, serum bone metabolism biomarkers, conception rate, and calving rate of grazing yaks. Ninety 3 year old yak heifers (153 ...
DOI:
10.3390/ani11020554

33. Efficacy of Tocilizumab Therapy in Different Subtypes of COVID-19 Cytokine Storm Syndrome

Author:
Oleksandr Oliynyk; Wojciech Barg; Anna Slifirczyk; Yanina Oliynyk; Vitaliy Gurianov; Marta Rorat
Source:
Viruses 2021 v.13 no.6 pp. -
ISSN:
1999-4915
Subject:
C-reactive protein; COVID-19 infection; Severe acute respiratory syndrome coronavirus 2; blood serum; calcitonin; ferritin; fibrinogen; interleukin-6; macrophage activation; mortality; pneumonia; retrospective studies; therapeutics
Abstract:
... Background: Cytokine storm in COVID-19 is heterogenous. There are at least three subtypes: cytokine release syndrome (CRS), macrophage activation syndrome (MAS), and sepsis. Methods: A retrospective study comprising 276 patients with SARS-CoV-2 pneumonia. All patients were tested for ferritin, interleukin-6, D-Dimer, fibrinogen, calcitonin, and C-reactive protein. According to the diagnostic crite ...
DOI:
10.3390/v13061067

34. Histopathological and Immunohistochemical Characteristics of Thyroid Carcinoma in the Dog

Author:
L.M.C. Soares; A.H.B. Pereira; C.G. de Campos; L.S. Rocha; T.Á. dos Santos; M.A. Souza; P.C. Jark; C.A. Pescador
Source:
Journal of comparative pathology 2020 v.177 pp. 34-41
ISSN:
0021-9975
Subject:
calcitonin; carcinoma; dogs; estrogen receptors; estrogens; histopathology; immunohistochemistry; pathogenesis; thyroglobulin
Abstract:
... Thyroid carcinomas are a common form of endocrine neoplasia in dogs. In the present study, we combined histopathology with immunohistochemistry (IHC) to search for the presence of oestrogen receptor alpha (ORα), Cox-2 and Ki67 in canine thyroid carcinomas. Forty-eight thyroid carcinomas were diagnosed throughout the study period. Thyroglobulin and calcitonin IHC distinguished between thyroid tumou ...
DOI:
10.1016/j.jcpa.2020.04.002

35. Improvement of eggshell quality by dietary N-carbamylglutamate supplementation in laying chickens

Author:
Yanfen Ma; Jinwei Yao; Shuo Zhou; Yuling Mi; Jian Li; Caiqiao Zhang
Source:
Poultry science 2020 v.99 no.8 pp. 4085-4095
ISSN:
0032-5791
Subject:
Western blotting; absorption; amino acids; blood sampling; blood vessels; calbindin; calcification; calcitonin; calcium; carbonate dehydratase; chicks; duodenum; egg shell; egg shell thickness; eggs; endometrium; estradiol; feed supplements; gene expression regulation; genes; hen feeding; hormone secretion; iron; kidneys; laying hens; liquid nitrogen; magnesium; messenger RNA; minerals; ovalbumin; parathyroid hormone; phosphorus; potassium; quantitative polymerase chain reaction; sodium; specific gravity; villi
Abstract:
... Egg quality defects seriously reduce the quality grade and increase egg breakage in egg marketing activities. In this study, the effect of N-carbamylglutamate (NCG) on eggshell quality was investigated by evaluating calcium absorption and calcification in laying hens. A total of 30 newly hatched female Hy-Line chicks were randomly assigned to the control group (basal diet) and treatment group (bas ...
DOI:
10.1016/j.psj.2020.04.004

36. Intermedin attenuates macrophage phagocytosis via regulation of the long noncoding RNA Dnm3os/miR-27b-3p/SLAMF7 axis in a mouse model of atherosclerosis in diabetes

Author:
Yanling Su; Ping Guan; Dandan Li; Yanwen Hang; Xiaomiao Ye; Lu Han; Yi Lu; Xiaolu Bai; Peng Zhang; Wei Hu
Source:
Biochemical and biophysical research communications 2021 v.583 pp. 35-42
ISSN:
0006-291X
Subject:
atherosclerosis; calcitonin; diabetes; glucose; high fat diet; lipoproteins; macrophages; males; mice; non-coding RNA; phagocytosis; research; streptozotocin
Abstract:
... Atherosclerosis in diabetes is a leading cause of cardiovascular complications. Intermedin (IMD) is a calcitonin peptide that is known to inhibit macrophage phagocytosis in atherosclerosis, but the exact mechanism is unclear. We investigate genes that are differentially expressed in response to IMD in hyperglycemic conditions and determine whether they delay the progression of atherosclerosis. An ...
DOI:
10.1016/j.bbrc.2021.10.038

37. Pro‐islet amyloid polypeptide in micelles contains a helical prohormone segment

Author:
Charles F. DeLisle; Alexander L. Malooley; Indrani Banerjee; Justin L. Lorieau
Source:
FEBS journal 2020 v.287 no.20 pp. 4440-4457
ISSN:
1742-464X
Subject:
amyloid; calcitonin; databases; energy; homeostasis; hunger; insulin; lipids; magnetism; micelles; noninsulin-dependent diabetes mellitus; pH; polypeptides; satiety; surfactants; topology
Abstract:
... Pro‐islet amyloid polypeptide (proIAPP) is the prohormone precursor molecule to IAPP, also known as amylin. IAPP is a calcitonin family peptide hormone that is cosecreted with insulin, and largely responsible for hunger satiation and metabolic homeostasis. Amyloid plaques containing mixtures of mature IAPP and misprocessed proIAPP deposit on, and destroy pancreatic β‐cell membranes, and they are r ...
DOI:
10.1111/febs.15253

38. Skin and bone development in Atlantic salmon (Salmo salar) influenced by hatchery environment

Author:
Nicholas Robinson; Christian Karlsen; Elisabeth Ytteborg; Aleksei Krasnov; Jascha Gerwins; Hanne Johnsen; Jelena Kolarevic
Source:
Aquaculture 2021 v.544 pp. 737155
ISSN:
0044-8486
Subject:
Salmo salar; biosecurity; calcitonin; collagen; cytoskeleton; early development; eggs; gene expression; hatcheries; inner ear; keratin; metalloproteinases; mineralization; salmon; skeletal development; skeleton
Abstract:
... Recirculating aquaculture systems (RAS) are receiving greater attention because they have potential to reduce the use of water, enable better control of environmental conditions and give greater biosecurity. However, little is known about the effects of conditions in RAS on early development. Here we compare the survival, development and gene expression of Atlantic salmon grown in a RAS and flow t ...
DOI:
10.1016/j.aquaculture.2021.737155

39. Spatiotemporally controlled calcitonin delivery: Long-term and targeted therapy of skeletal diseases

Author:
Peng Yu; Yanpeng Liu; Jing Xie; Jianshu Li
Source:
Journal of controlled release 2021 v.338 pp. 486-504
ISSN:
0168-3659
Subject:
bioavailability; biocompatible materials; calcitonin; calcium; chemical bonding; half life; hydrogels; hypercalcemia; inflammation; metabolism; osteoarthritis; osteoblasts; osteoclasts; osteoporosis; polymers; therapeutics; thermosensitivity
Abstract:
... Bone is a connective tissue that support the entire body and protect the internal organs. However, there are great challenges on curing intractable skeletal diseases such as hypercalcemia, osteoporosis and osteoarthritis. To address these issues, calcitonin (CT) therapy is an effective treatment alternative to regulate calcium metabolism and suppress inflammation response, which are closely relate ...
DOI:
10.1016/j.jconrel.2021.08.056

40. Structural and molecular characteristics of axons in the long head of the biceps tendon

Author:
Roland Blumer; Sandra Boesmueller; Bernhard Gesslbauer; Lena Hirtler; Daniel Bormann; Angel M. Pastor; Johannes Streicher; Rainer Mittermayr
Source:
Cell and tissue research 2020 v.380 no.1 pp. 43-57
ISSN:
0302-766X
Subject:
antibodies; axons; blood vessels; calcitonin; females; genes; innervation; males; myelin basic protein; myelination; nerve tissue; pain; substance P; tyrosine 3-monooxygenase
Abstract:
... The innervation of the long head of the biceps tendon (LHBT) is not sufficiently documented. This is a drawback since pathologies of the LHBT are a major source of shoulder pain. Thus, the study aimed to characterize structurally and molecularly nervous elements of the LHBT. The proximal part of 11 LHBTs was harvested intraoperatively. There were 8 female and 3 male specimens. Age ranged from 66 t ...
DOI:
10.1007/s00441-019-03141-4

41. Therapeutic effects of calcitonin gene-related peptide-modified bone marrow mesenchymal stem cells combined with autogenous bone grafting for treatment of osteonecrosis of the femoral head in rabbits

Author:
Jinfeng Li; Guowei Shang; Yisheng Wang; Xiuli Wang; Yuanyuan Ji; Yuebai Li
Source:
Biochemical engineering journal 2020 v.153 pp. 107399
ISSN:
1369-703X
Subject:
bone formation; bone marrow; calcitonin; calcitonin gene-related peptide; collagen; compression strength; femur; genes; laminin; mesenchymal stromal cells; messenger RNA; models; modulus of elasticity; osteonecrosis; protein synthesis; rabbits; therapeutics
Abstract:
... Calcitonin gene-related peptide (CGRP) promotes proliferation and osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs), which influence bone regeneration and reconstruction. We previously established CGRP-modified BMSCs that express the CGRP gene and demonstrated that this elevated CGRP expression promotes osteogenic differentiation of BMSCs. The current study investigated the ...
DOI:
10.1016/j.bej.2019.107399

42. Viral depletion of calcitonin receptors in the area postrema: A proof-of-concept study

Author:
Bernd Coester; Christelle Le Foll; Thomas A. Lutz
Source:
Physiology & behavior 2020 v.223 pp. 112992
ISSN:
0031-9384
Subject:
Dependoparvovirus; agonists; behavior; brain; calcitonin; food intake; green fluorescent protein; insulin; mice; neurons; recombinases; salmon; satiety
Abstract:
... The area postrema (AP), located in the caudal hindbrain, is one of the primary binding sites for the endocrine satiation hormone amylin. Amylin is co-secreted with insulin from pancreatic ß-cells and binds to heterodimeric receptors that consist of a calcitonin core receptor (CTR) paired with receptor-activity modifying protein (RAMP) 1 or 3. In this study, we aim to validate a CTR-floxed (CTRᶠˡ/ᶠ ...
DOI:
10.1016/j.physbeh.2020.112992

43. “Gold-plated” IRMOF-3 and sea cucumber-like Pd@PtRh SNRs based sandwich-type immunosensor for dual-mode detection of PCT

Author:
Hui Dong; Linlin Cao; Huan Zhao; Shanghua Liu; Qing Liu; Ping Wang; Zhen Xu; Shujun Wang; Yueyuan Li; Peiqing Zhao; Yueyun Li
Source:
Biosensors & bioelectronics 2020 v.170 pp. 112667
ISSN:
0956-5663
Subject:
biomarkers; blood serum; calcitonin; catalytic activity; durability; electrochemistry; humans; immunosensors; nanocomposites; nanogold; nanorods; voltammetry
Abstract:
... Electrochemical immunoassays are often used in the detection of biomarkers, and their sensitivity depends on the nature of the substrate and the catalytic activity of the signal amplification platform. In this work, a novel sandwich-type signal amplification strategy with a “gold-plated” organometallic frame (Au/IRMOF-3) as the substrate and the sea cucumber-like Pd@PtRh trimetallic nanomaterial ( ...
DOI:
10.1016/j.bios.2020.112667

44. Adrenomedullin – Current perspective on a peptide hormone with significant therapeutic potential

Author:
Jan-Patrick Fischer; Sylvia Els-Heindl; Annette G. Beck-Sickinger
Source:
Peptides 2020 v.131 pp. 170347
ISSN:
0196-9781
Subject:
amino acids; bioactive properties; calcitonin; calcitonin gene-related peptide; half life; humans; ligands; lymphatic system; peptide hormones; receptors; sequence analysis; therapeutics
Abstract:
... The peptide hormone adrenomedullin (ADM) consists of 52 amino acids and plays a pivotal role in the regulation of many physiological processes, particularly those of the cardiovascular and lymphatic system. Like calcitonin (CT), calcitonin gene-related peptide (CGRP), intermedin (IMD) and amylin (AMY), it belongs to the CT/CGRP family of peptide hormones, which despite their low little sequence id ...
DOI:
10.1016/j.peptides.2020.170347

45. Adrenomedullin: Continuing to explore cardioprotection

Author:
Toshihiro Tsuruda; Johji Kato; Kenji Kuwasako; Kazuo Kitamura
Source:
Peptides 2019 v.111 pp. 47-54
ISSN:
0196-9781
Subject:
aldosterone; amino acids; angiogenesis; apoptosis; biomarkers; calcitonin; cardioprotective effect; clinical trials; cyclic AMP; disulfide bonds; embryogenesis; gene transfer; half life; heart failure; humans; hypertrophy; myocardial infarction; myocardium; oxidative stress; rodents; secretion; therapeutics; vasodilation
Abstract:
... Adrenomedullin (AM), a peptide isolated from an extract of human pheochromocytoma, comprises 52 amino acids with an intramolecular disulfide bond and amidation at the carboxy-terminus. AM is present in various tissues and organs in rodents and humans, including the heart. The peptide concentration increases with cardiac hypertrophy, acute myocardial infarction, and overt heart failure in the plasm ...
DOI:
10.1016/j.peptides.2018.03.012

46. Development of a polysaccharide based multi-unit nanofiber mat for colon-targeted sustained release of salmon calcitonin

Author:
Kun Feng; Chen Li; Yun-Shan Wei; Min-Hua Zong; Hong Wu; Shuang-Yan Han
Source:
Journal of colloid and interface science 2019 v.552 pp. 186-195
ISSN:
0021-9797
Subject:
bioactive properties; bioavailability; calcitonin; colon; encapsulation; in vitro studies; mathematical models; nanofibers; oral administration; pectins; proteins; salmon; sodium alginate
Abstract:
... Advances in pharmaceutical technology have promoted the development of colon-targeted delivery system for oral administration of bioactive peptides or proteins to enhance their bioavailability. In this study, a multi-unit nanofiber mat was fabricated by coaxial electrospinning and its feasibility as the colon-targeted delivery system for a bioactive peptide, salmon calcitonin (sCT), was investigat ...
DOI:
10.1016/j.jcis.2019.05.037

47. Development of a system for measuring calcitonin in the stingray Dasyatis akajei (a cartilaginous fish): the possible involvement of stingray calcitonin in gonadal development

Author:
Takashi Takagi; Toshio Sekiguchi; Yuichi Sasayama; Atsuhiko Hattori; Takushi X. Watanabe; Yoichiro Kitani; Yoshiaki Tabuchi; Hajime Matsubara; Ajai K. Srivastav; Tran Ngoc Hai; Thumronk Amornsakun; Nobuo Suzuki
Source:
International aquatic research 2019 v.11 no.3 pp. 267-276
ISSN:
2008-4935
Subject:
Dasyatis; adjuvants; affinity chromatography; antibodies; antiserum; body weight; calcitonin; calcium; chlorine; egg yolk; enzyme-linked immunosorbent assay; gonads; inorganic phosphorus; liver; magnesium; muscles; osmoregulation; research; secretion; sodium; urea
Abstract:
... To elucidate the physiological role of calcitonin (CT) in stingrays (cartilaginous fish), an enzyme-linked immunosorbent assay (ELISA) system using a specific antibody against stingray CT has been developed. Synthetic stingray CT was subcutaneously injected into mice four times—once every 2 weeks—together with an adjuvant. We purified the IgG antibody fraction using the protein A affinity chromato ...
DOI:
10.1007/s40071-019-00236-0

48. Effect of Qinbai Qingfei Concentrated Pellets on substance P and neutral endopeptidase of rats with post-infectious cough

Author:
Weigang Jia; Wei Wang; Rui Li; Quanyu Zhou; Ying Qu; Yumei Jia; Zhiheng Zhang; Chengwei Wan; Wanwan Zhang
Source:
BMC complementary medicine and therapies 2020 v.20 no.1 pp. 289
ISSN:
2662-7671
Subject:
alternative medicine; blood serum; bronchi; calcitonin; capsaicin; cigarettes; cough; drugs; genes; histopathology; inflammation; interleukin-10; interleukin-13; interleukin-6; interleukin-8; lipopolysaccharides; malondialdehyde; neutrophils; protective effect; rats; sawdust; secretion; substance P; superoxide dismutase
Abstract:
... BACKGROUND: In recent years, it has been reported that Qinbai Qingfei Concentrated Pellet (QQCP) has the effect of relieving cough and reducing sputum. However, the therapeutic potentials of QQCP on post-infectious cough (PIC) rat models has not been elucidated. So the current study was aimed to scientifically validate the efficacy of QQCP in post infectious cough. METHODS: All rats were exposed t ...
DOI:
10.1186/s12906-020-03081-5

49. Effect of dietary 25-hydroxycholecalciferol supplementation and high stocking density on performance, egg quality, and tibia quality in laying hens

Author:
Jianping Wang; Lingyun Qiu; Haojie Gong; Pietro Celi; Lei Yan; Xuemei Ding; Shiping Bai; Qiufeng Zeng; Xiangbing Mao; Shengyu Xu; Caimei Wu; Keying Zhang
Source:
Poultry science 2020 v.99 no.5 pp. 2608-2615
ISSN:
0032-5791
Subject:
25-hydroxycholecalciferol; ash content; blood serum; calcitonin; calcium; carbonate dehydratase; color; corticosterone; egg shell; egg shell thickness; egg weight; feed intake; feed supplements; hen feeding; laying hens; lipopolysaccharides; osteocalcin; parathyroid hormone; rearing; stocking rate; tibia
Abstract:
... This study was conducted to determine the effects of 25-hydroxycholecalciferol (25-OH-D₃) on performance, egg quality, tibia quality, and serum hormones concentration in laying hens reared under high stocking density. A total of 800 45-week-old Lohmann laying hens were randomly allotted into a 2 × 2 factorial design with 2 levels of dietary 25-OH-D₃ levels (0 and 69 μg/kg) and 2 rates of stocking ...
DOI:
10.1016/j.psj.2019.12.054

50. Effect of inorganic phosphate supplementation on egg production in Hy-Line Brown layers fed 2000 FTU/kg phytase

Author:
X. Cheng; J. K. Yan; W. Q. Sun; Z. Y. Chen; S. R. Wu; Z. Z. Ren; X. J. Yang
Source:
Animal 2020 v.14 no.11 pp. 2246-2252
ISSN:
1751-732X
Subject:
blood serum; calcitonin; calcium; color; duodenum; egg masses; egg production; egg weight; eggs; excretion; feed conversion; feed intake; gene expression; inorganic phosphorus; metabolism; parathyroid hormone; phosphates; phytases; symporters; tibia
Abstract:
... Phytase has long been used to decrease the inorganic phosphorus (Pi) input in poultry diet. The current study was conducted to investigate the effects of Pi supplementation on laying performance, egg quality and phosphate–calcium metabolism in Hy-Line Brown laying hens fed phytase. Layers (n = 504, 29 weeks old) were randomly assigned to seven treatments with six replicates of 12 birds. The corn–s ...
DOI:
10.1017/S1751731120001597