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You searched for: Subject calcitonin receptors Remove constraint Subject: calcitonin receptors Subject cyclic AMP Remove constraint Subject: cyclic AMP Subject calcitonin Remove constraint Subject: calcitonin Text Availability Citation in PubAg Remove constraint Text Availability: Citation in PubAg
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1. Inhibitory effects of two G protein-coupled receptor kinases on the cell surface expression and signaling of the human adrenomedullin receptor

Author:
Kenji Kuwasako; Toshio Sekiguchi; Sayaka Nagata; Danfeng Jiang; Hidetaka Hayashi; Manabu Murakami; Yuichi Hattori; Kazuo Kitamura; Johji Kato
Source:
Biochemical and biophysical research communications 2016 v.470 pp. 894-899
ISSN:
0006-291X
Subject:
calcitonin; calcitonin receptors; cyclic AMP; flow cytometry; gene overexpression; humans; iodine; mutants; phosphotransferases (kinases)
Abstract:
... Receptor activity-modifying protein 2 (RAMP2) enables the calcitonin receptor-like receptor (CLR, a family B GPCR) to form the type 1 adrenomedullin receptor (AM1 receptor). Here, we investigated the effects of the five non-visual GPCR kinases (GRKs 2 through 6) on the cell surface expression of the human (h)AM1 receptor by cotransfecting each of these GRKs into HEK-293 cells that stably expressed ...
DOI:
10.1016/j.bbrc.2016.01.138

2. STC1 interference on calcitonin family of receptors signaling during osteoblastogenesis via adenylate cyclase inhibition

Author:
Silvia R. Terra; João Carlos R. Cardoso; Rute C. Félix; Leo Anderson M. Martins; Diogo Onofre G. Souza; Fatima C.R. Guma; Adelino Vicente M. Canário; Vanessa Schein
Source:
Molecular and Cellular Endocrinology 2015 v.403 pp. 78-87
ISSN:
0303-7207
Subject:
G-proteins; adenylate cyclase; bone formation; calcitonin; calcitonin gene-related peptide; calcitonin receptors; cyclic AMP; forskolin; gene expression; osteoblasts; plasma membrane
Abstract:
... Stanniocalcin 1 (STC1) and calcitonin gene-related peptide (CGRP) are involved in bone formation/remodeling. Here we investigate the effects of STC1 on functional heterodimer complex CALCRL/RAMP1, expression and activity during osteoblastogenesis. STC1 did not modify CALCRL and ramp1 gene expression during osteoblastogenesis when compared to controls. However, plasma membrane spatial distribution ...
DOI:
10.1016/j.mce.2015.01.010

3. The role of the ERK1/2 pathway as an alternative to the aging-diminished cyclic AMP pathway in calcitonin-mediated chondrogenesis in human nucleus pulposus

Author:
Wei-Hong Chen; Rong Zeng; Wen-Cheng Lo; Szu-Yu Tina Chen; Tung-Yuan Lai; David F. Williams; Win-Ping Deng
Source:
Biomaterials 2012 v.33 no.33 pp. 8256-8264
ISSN:
0142-9612
Subject:
calcitonin; calcitonin receptors; chondrogenesis; cyclic AMP; humans; phenotype; signal transduction; therapeutics
Abstract:
... Human disc degeneration initiated by aging in the central nucleus pulposus (hNP) is an irreversible process and the recovery has become seriously emerging. In this study, the related mechanisms of calcitonin on the regeneration of hNP and the effects of calcitonin on the age-related alterations were examined. The harvested hNP population was designated as YhNP (from young donor, age <50) and OhNP ...
DOI:
10.1016/j.biomaterials.2012.06.088

4. Structure–function analysis of amino acid 74 of human RAMP1 and RAMP3 and its role in peptide interactions with adrenomedullin and calcitonin gene-related peptide receptors

Author:
Tao Qi; Kien Ly; David R. Poyner; George Christopoulos; Patrick M. Sexton; Debbie L. Hay
Source:
Peptides 2011 v.32 no.5 pp. 1060-1067
ISSN:
0196-9781
Subject:
amino acid composition; amino acids; calcitonin; calcitonin gene-related peptide; calcitonin receptors; cyclic AMP; enzyme-linked immunosorbent assay; humans; mutants; pharmacology
Abstract:
... The receptors for calcitonin gene-related peptide (CGRP) and adrenomedullin (AM) are complexes of the calcitonin receptor-like receptor (CLR) and receptor activity-modifying proteins (RAMP). The CGRP receptor is a CLR/RAMP1 pairing whereas CLR/RAMP2 and CLR/RAMP3 constitute two subtypes of AM receptor: AM₁ and AM₂, respectively. Previous studies identified Glu74 in RAMP3 to be important for AM bin ...
DOI:
10.1016/j.peptides.2011.03.004