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1. Anti-tumor efficacy of Habb-e-Asgandh as an adjuvant therapy in chronic myelogenous leukemia in vitro

Author:
Nidhi Gupta; Sumiran Kumar Gurung; Dayasagar Das; Sana Nafees; Alpana Sharma
Source:
Journal of herbal medicine 2022 v.35 pp. 100584
ISSN:
2210-8033
Subject:
adjuvants; antineoplastic activity; apoptosis; arthritis; cell cycle; cell lines; cell movement; cytotoxicity; drug therapy; herbal medicines; interleukin-6; membrane potential; mitochondrial membrane; myeloid leukemia; oxidative stress; propidium; toxicity testing
Abstract:
... Chronic myeloid leukemia (CML) is a myeloproliferative hematological malignancy wherein the increased relapsed cases and lack of drug effectiveness generates a need to identify an effective treatment regimen. A unani formulation, Habb-e-Asgandh (HEA) is being used for treatment of ailments such as arthritis, however, its role in CML therapeutics has not been reported yet. Hence, anti-leukemic effi ...
DOI:
10.1016/j.hermed.2022.100584

2. Antibiofilm and anticancer activities of unripe and ripe Azadirachta indica (neem) seed extracts

Author:
Kartik Chandra Guchhait; Tuhin Manna; Manas Barai; Monalisha Karmakar; Sourav Kumar Nandi; Debarati Jana; Aditi Dey; Suman Panda; Priyanka Raul; Anuttam Patra; Rittwika Bhattacharya; Subhrangsu Chatterjee; Amiya Kumar Panda; Chandradipa Ghosh
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 42
ISSN:
2662-7671
Subject:
Azadirachta indica; Staphylococcus aureus; Vibrio cholerae; acridine orange; alternative medicine; antibacterial properties; antibiotics; antineoplastic activity; bacterial culture; biofilm; breast neoplasms; cell lines; cytotoxicity; ethidium; fluorescence microscopy; gas chromatography; humans; mass spectrometry; methanol; minimum inhibitory concentration; multiple drug resistance; neoplasm cells; phthalic acid; toxicity testing; triazines
Abstract:
... BACKGROUND: Antibiotic resistances of pathogens and breast cancer warrant the search for new alternative strategies. Phytoextracts can eradicate microbe-borne diseases as well as cancer with lower side effects compared to conventional antibiotics. AIM: Unripe and ripe Azadirachta indica (neem) seed extracts were explored as potential antibiofilm and anticancer agents in combating multidrug-resista ...
DOI:
10.1186/s12906-022-03513-4

3. Anticancer activity and QSAR study of sulfur-containing thiourea and sulfonamide derivatives

Author:
Ratchanok Pingaew; Veda Prachayasittikul; Apilak Worachartcheewan; Anusit Thongnum; Supaluk Prachayasittikul; Somsak Ruchirawat; Virapong Prachayasittikul
Source:
Heliyon 2022 pp. e10067
ISSN:
2405-8440
Subject:
algorithms; antineoplastic activity; cell lines; computer simulation; cytotoxicity; neoplasm cells; quantitative structure-activity relationships; regression analysis; thiourea; van der Waals forces
Abstract:
... Sulfur-containing compounds are considered as attractive pharmacophores for discovery of new drugs regarding their versatile properties to interaction with various biological targets. Quantitative structure-activity relationship (QSAR) modeling is one of well-recognized in silico tools for successful drug discovery. In this work, a set of 38 sulfur-containing derivatives (Types I - VI) were evalua ...
DOI:
10.1016/j.heliyon.2022.e10067

4. Antimicrobial activity, in vitro anticancer effect (MCF-7 breast cancer cell line), antiangiogenic and immunomodulatory potentials of Populus nigra L. buds extract

Author:
Brigitta Kis; Ioana Zinuca Pavel; Stefana Avram; Elena Alina Moaca; Martina Herrero San Juan; Anja Schwiebs; Heinfried H. Radeke; Delia Muntean; Zorita Diaconeasa; Daliana Minda; Camelia Oprean; Florina Bojin; Cristina Adriana Dehelean; Codruta Soica; Corina Danciu
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 74
ISSN:
2662-7671
Subject:
Populus nigra; alternative medicine; antimicrobial properties; antineoplastic activity; antioxidant activity; apoptosis; breast neoplasms; cell cycle checkpoints; cell lines; cell viability; chemical constituents of plants; chorioallantoic membrane; dose response; humans; immunomodulators; interleukin-12; interleukin-23; neoplasm cells; toxicity; Romania
Abstract:
... PURPOSE: The aim of this study was to evaluate the antioxidant potential, antimicrobial activity, the in vitro anticancer effect (tested on MCF-7 breast cancer cell line), as well as the antiangiogenic and immunomodulatory potential of Populus nigra L. bud (Pg) extract collected from the western part of Romania. RESULTS: Populus nigra L. bud extract presents an important antioxidant activity, due ...
DOI:
10.1186/s12906-022-03526-z

5. Antioxidant, anti-cancer, and debittering potential of edible fungi (Aspergillus oryzae) for bioactive ingredient in personalized foods

Author:
Sukhvinder Singh Purewal; Pinderpal Kaur; Gagandeep Garg; Kawaljit Singh Sandhu; Raj Kumar Salar
Source:
Biocatalysis and agricultural biotechnology 2022 v.43 pp. 102406
ISSN:
1878-8181
Subject:
Aspergillus oryzae; agricultural biotechnology; antineoplastic activity; antioxidants; ascorbic acid; benzoic acid; biocatalysis; breast neoplasms; catechin; catechol; cell lines; cinnamic acid; debittering; ethanol; fungal biomass; fungal enzymes; gallic acid; ingredients; limonin; mandarins; metabolites; methanol; mycelium; naringin; naringinase; neoplasm cells; p-coumaric acid; saponins; toxicity testing
Abstract:
... Fungal strain Aspergillus oryzae (MTCC 3107) was screened for antioxidant, anti-cancer, and debittering applications. Three different extraction solvents (water, aqueous ethanol 50%, and methanol 100%) were used to extract bioactive compounds from fungal biomass. Further mycelial mass was recovered, dried, and evaluated for mycochemicals and antioxidant properties. Naringinase production by A. ory ...
DOI:
10.1016/j.bcab.2022.102406

6. Arborinine suppresses ovarian cancer development through inhibition of LSD1

Author:
Nan Li; Liang Yang; Hongling Zuo
Source:
Life sciences 2022 v.291 pp. 120275
ISSN:
0024-3205
Subject:
Western blotting; antineoplastic activity; antineoplastic agents; cancer therapy; carcinogenesis; cell lines; cell movement; cell proliferation; cytotoxicity; dose response; drug therapy; epithelium; females; gene expression; mice; neoplasm cells; ovarian neoplasms; paclitaxel; toxicity testing
Abstract:
... Epithelial ovarian carcinoma is the most lethal female reproductive malignancy in the world. Paclitaxel and carboplatin are generally the first-line treatment drugs for ovarian cancer patients, but numerous patients may develop chemotherapy resistance. Thus, it is urgent to identify novel drugs for ovarian cancer treatment. Arborinine has been known as a broad-spectrum anti-tumor agent due to it p ...
DOI:
10.1016/j.lfs.2021.120275

7. Assessing the Protective Effect of Moringa oleifera Extract against Bone Metastasis: An In Vitro Simulated Digestion Approach

Author:
Kinjal P. Bhadresha; Nayan K. Jain; Rakesh M. Rawal
Source:
Nutrition and cancer 2022 v.74 no.3 pp. 1023-1036
ISSN:
1532-7914
Subject:
Moringa oleifera; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; bioactive compounds; bioavailability; cell lines; cell viability; cytotoxicity; digestion; flavonoids; gene expression; glutathione; interphase; metastasis; polyphenols; prostatic neoplasms; protective effect; spectral analysis
Abstract:
... Moringa oleifera possesses numerous advantageous effects like anti-microbial, antioxidant, and anti-inflammatory, leaves contain a high multiplicity of the bioactive compound; however, little is identified about its bioaccessibility. The objective of this study was to assess the bioefficacy, bioaccessible and anticancer activity of Moringa oleifera in a PC3 cell line before and after simulated in ...
DOI:
10.1080/01635581.2021.1933099

8. Association between extract of Euphorbia szovitsii and expression level of microRNAs in MDA-MB-231 cell line

Author:
Majid Asadi-Samani; Mohammad-Reza Mahmoudian-Sani
Source:
Molecular biology reports 2022 v.49 no.5 pp. 3531-3537
ISSN:
0301-4851
Subject:
Euphorbia; antineoplastic activity; apoptosis; breast neoplasms; cell lines; cell proliferation; microRNA; molecular biology
Abstract:
... BACKGROUND: The miRNAs have been shown to be involved in breast cancer. The aim of the present research was to evaluate the impacts of extract from Euphorbia szovitsii Fisch & C.A. Mey on the expression level of microRNAs in triple-negative breast cancer (MDA-MB-231) cell line. METHODS AND RESULT: The alterations in the expression level of miRNAs in MDA-MB-231 cell line exposed to the extract of E ...
DOI:
10.1007/s11033-022-07193-8

9. Biofunctionalized silver nanoparticles synthesized from Passiflora vitifolia leaf extract and evaluation of its antimicrobial, antioxidant and anticancer activities

Author:
Dhanyakumara Shivapoojar Basavarajappa; Raju Suresh Kumar; Abdulrahman I. Almansour; Bidhayak Chakraborty; Meghashyama Prabhakara Bhat; Shashiraj Kariyellappa Nagaraja; Halaswamy Hiremath; Karthikeyan Perumal; Sreenivasa Nayaka
Source:
Biochemical engineering journal 2022 pp. 108517
ISSN:
1369-703X
Subject:
Fourier transform infrared spectroscopy; Passiflora; X-ray diffraction; absorption; antimicrobial properties; antineoplastic activity; antioxidant activity; antioxidants; atomic force microscopy; cell lines; leaf extracts; macrophages; mice; nanosilver; transmission electron microscopy; zeta potential
Abstract:
... The present study describes the synthesis of silver nanoparticles (AgNPs) using Passiflora vitifolia (P. vitifolia) leaf extract as reducing and capping agent. Characterization of the synthesized AgNPs was done with the help of UV-Vis. spectroscopy, atomic force microscopy (AFM), fourier transform infrared microscopy (FTIR), zeta potential, thermo gravimetric analysis (TGA), scanning electron micr ...
DOI:
10.1016/j.bej.2022.108517

10. Biosynthesized tin oxide-sodium alginate-polyethylene glycol-carvacrol nanocomposite shows anticancer activity on esophagus squamous carcinoma cells

Author:
Gongqian Jiang; Abubucker Peer Mohideen; Vidya Devanathadesikan Seshadri; Thamaraiselvan Rengarajan
Source:
Process biochemistry 2022 v.121 pp. 403-412
ISSN:
1359-5113
Subject:
Fourier transform infrared spectroscopy; Lamiaceae; antimicrobial properties; antineoplastic activity; antineoplastic agents; antioxidants; apoptosis; biosynthesis; carcinoma; carvacrol; cell cycle; cell lines; cytotoxicity; esophageal neoplasms; esophagus; monoterpenoids; nanocomposites; neoplasm cells; oxidative stress; polyethylene glycol; regulatory proteins; rhodamines; sodium; spectral analysis; tin; tin dioxide; toxicity testing
Abstract:
... Esophagus cancer is the sixth leading cause of cancer-related mortalities worldwide. In this study, we synthesized a biocompatible nanocomposite with green synthesized tin oxide using carvacrol, sodium allyl, and polyethylene glycol. Carvacrol is a phenolic monoterpenoid extracted from the essential oils of the plants belonging to the Lamiaceae family. Carvacrol possesses immense pharmacological p ...
DOI:
10.1016/j.procbio.2022.07.005

11. The Bovine Serum Albumin Coated Copper Oxide Nanoparticle for Curcumin Delivery in Biological Environment: In-vitro Drug Release

Author:
Tahmineh Atloo; Ramin Mohammadkhani; Ali Mohammadi; Kasra Arbabi Zaboli; Saeed Kaboli; Hossein Rahimi; Hamed Nosrati; Hosein Danafar
Source:
Journal of polymers and the environment 2022 v.30 no.8 pp. 3203-3208
ISSN:
1566-2543
Subject:
antineoplastic activity; antineoplastic agents; atomic force microscopy; bovine serum albumin; breast neoplasms; cell lines; cupric oxide; curcumin; cytotoxicity; environment; nanocarriers; neoplasm cells; pH; particle size; toxicity testing; transmission electron microscopy
Abstract:
... The copper oxide nanoparticles (CuO NPs) were synthesized by a simple method and then coated with the bovine serum albumin (BSA) to form CuO@BSA NPs. Finally, curcumin (CUR) as an anticancer drug was loaded to the CuO@BSA NPs. The characterization of nanoparticles was carried out by Fourier-transport infrared (FT-IR), ultraviolet-visible (UV-vis), transmission electron microscopy (TEM), and atomic ...
DOI:
10.1007/s10924-022-02401-9

12. Comparative Evaluation of the Potential Antitumor of Helleborus purpurascens in Skin and Breast Cancer

Author:
Ciprian Nicolae Pilut; Aniko Manea; Ioana Macasoi; Amadeus Dobrescu; Doina Georgescu; Roxana Buzatu; Alin Faur; Stefania Dinu; Doina Chioran; Iulia Pinzaru; Monica Hancianu; Cristina Dehelean; Daniel Malița
Source:
Plants 2022 v.11 no.2 pp. -
ISSN:
2223-7747
Subject:
Helleborus; antineoplastic activity; antioxidant activity; apoptosis; ascorbic acid; breast neoplasms; cancer therapy; cell lines; cytotoxicity; epicatechin; kaempferol; neoplasm cells; quercetin
Abstract:
... In the field of oncology, the plant kingdom has an inexhaustible supply of bioactive compounds. Phytochemical compounds isolated from Helleborus species have been found to be useful in various chronic diseases. This has brought Helleborus to the attention of medical researchers. H. purpurascens is a plant characteristic of the Carpathian area, known since ancient times for its beneficial effects. ...
DOI:
10.3390/plants11020194

13. Complexation-induced nanoarchitectonics of sulfonate cailx[4]resorcinol substituted at the upper rim by N-methyl-d-glucamine fragments: Morphological transition and in vitro anticancer activity

Author:
Nadezda E. Kashapova; Ruslan R. Kashapov; Albina Y. Ziganshina; Syumbelya K. Amerhanova; Anna P. Lyubina; Alexandra D. Voloshina; Vadim V. Salnikov; Lucia Y. Zakharova
Source:
Colloids and surfaces 2022 v.643 pp. 128796
ISSN:
0927-7757
Subject:
antineoplastic activity; cell lines; copper; cytotoxicity; ligands; liver; neoplasms; resorcinol; sulfonates
Abstract:
... Complexes of various nitrogen-containing ligands with transition metals are known for their anticancer activity. At the same time, the shape of aggregates of these complexes can have a significant effect on cytotoxicity and selectivity of action in tumor cells, however, this issue has received insufficient attention in the literature. In this work, the selective binding ability of sulfonate calix[ ...
DOI:
10.1016/j.colsurfa.2022.128796

14. Cytotoxic activity of crude extracts and fractions of African peach (nauclea latifolia smith) stem bark on two cancer cell lines

Author:
Oluwakemi Charles-Okhe; Michael A. Odeniyi; Titilayo O. Fakeye; Omonike O. Ogbole; Toluwanimi E. Akinleye; Adekunle J. Adeniji
Source:
Phytomedicine plus 2022 v.2 no.1 pp. 100212
ISSN:
2667-0313
Subject:
Cercopithecus aethiops; Sarcocephalus latifolius; antineoplastic activity; bark; bark extracts; breast neoplasms; cell lines; colorimetry; cytotoxicity; drug therapy; ethyl acetate; fractionation; hexane; kidneys; liquid chromatography; methanol; neoplasm cells; peaches; skeletal muscle; vincristine
Abstract:
... The purpose of this research work is to investigate and establish the anticancer (cytotoxic) properties of African peach (Nauclea latifolia) stem bark extract and fractions on breast cancer cell lines (MCF-7), skeletal muscle cancer (RD) cell lines and to determine the selectivity index (SI) on normal African green monkey kidney cell lines (Vero). Crude extract and fractions obtained from acid-bas ...
DOI:
10.1016/j.phyplu.2021.100212

15. Density functional theoretical study, spectroscopic characterization and molecular docking of the diuretic drug, spironolactone, adsorbed on AuNPs surface and in-vitro studies based on anticancer activity studies against A549 lung cancer cell line

Author:
V. Shyni; D.R. Leenaraj; Reena Ittyachan; Rejeena V. Rajan; G.J. Shyju; Lynnette Joseph; D. Sajan
Source:
Colloids and surfaces 2022 v.646 pp. 128255
ISSN:
0927-7757
Subject:
antineoplastic activity; cell lines; density functional theory; drugs; electron transfer; energy; gold; hydrogen; lung neoplasms; neoplasm cells; spectral analysis; spironolactone; therapeutics; toxicity testing; transmission electron microscopes
Abstract:
... In this study, the geometry, intramolecular charge transfer interactions, and harmonic vibrational frequencies of the diuretic drug, Spironolactone (SPL) and SPL adsorbed on gold nanoparticle (SPLA molecule) were investigated with the help of density functional theory method. Both molecules were found to be stabilized by intramolecular hydrogen bonds C₇-H₃₇. O₂₇ and C₁₆-H₄₇. O₂, as well as intramo ...
DOI:
10.1016/j.colsurfa.2022.128255

16. Design and prediction of novel pyrazole derivatives as potential anti-cancer compounds based on 2D-2D-QSAR study against PC-3, B16F10, K562, MDA-MB-231, A2780, ACHN and NUGC cancer cell lines

Author:
Fatima Ezzahra Bennani; Latifa Doudach; Khalid Karrouchi; Youssef El rhayam; Christopher E. Rudd; M’hammed Ansar; My El Abbes Faouzi
Source:
Heliyon 2022 v.8 no.8 pp. e10003
ISSN:
2405-8440
Subject:
antineoplastic activity; cell lines; models; mortality; neoplasm cells; prediction; principal component analysis; quantitative structure-activity relationships
Abstract:
... Despite the decades of scientific studies for developing promising new therapies, cancer remains a major cause of illness and mortality, worldwide. Several cancer types are the major topic of research in drug discovery programs due to their global incidence cases and growing frequency. In the present study, using two different statistical approaches PCA (principal component analysis) and PLS (part ...
DOI:
10.1016/j.heliyon.2022.e10003

17. Diadema setosum: isolation of bioactive secondary metabolites with cytotoxic activity toward human cervical cancer

Author:
Fahd M. Abdelkarem; Ezz-Eldin K. Desoky; Alaa M. Nafady; Ahmed E. Allam; Aldoushy Mahdy; Ahmed Ashour; Kuniyoshi Shimizu
Source:
Natural product research 2022 v.36 no.4 pp. 1118-1122
ISSN:
1478-6427
Subject:
antineoplastic activity; cell lines; chromatography; colorimetry; cytotoxicity; ethyl acetate; humans; neoplasm cells; nuclear magnetic resonance spectroscopy; research; secondary metabolites; uterine cervical neoplasms
Abstract:
... In our promising project toward discovery of secondary metabolites with potential anticancer activity against human cervical cancer, seven marine organisms were screened for their cytotoxic activity against HeLa cancer cell line using MTT colorimetric assay. The crude extract of the outer shell of Diadema setosum showed promising activity with 88.02% inhibition at a concentration 250 µg/ml. Chroma ...
DOI:
10.1080/14786419.2020.1855162

18. Ecofriendly Synthesis of Biosynthesized Copper Nanoparticles with Starch-Based Nanocomposite: Antimicrobial, Antioxidant, and Anticancer Activities

Author:
Mohamed Hasanin; Mohamed A. Al Abboud; Mohamed M. Alawlaqi; Tarek M. Abdelghany; Amr H. Hashem
Source:
Biological trace element research 2022 v.200 no.5 pp. 2099-2112
ISSN:
0163-4984
Subject:
Aspergillus niger; Bacillus subtilis; Candida albicans; Escherichia coli; Fourier transform infrared spectroscopy; X-ray diffraction; antifungal properties; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; biosynthesis; cell lines; copper nanoparticles; energy-dispersive X-ray analysis; nanocomposites; research; starch; trace elements; transmission electron microscopes; ultraviolet-visible spectroscopy
Abstract:
... In recent years, polysaccharides-based nanocomposites have been used for biomedical applications. In the current study, a nanocomposite based on myco-synthesized copper nanoparticles (CuNPs) and starch was prepared. The prepared nanocomposite was fully characterized using UV–visible spectroscopy (UV–vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron mi ...
DOI:
10.1007/s12011-021-02812-0

19. Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa

Author:
Fang-Yuan Zhang; Run-Ze Li; Cong Xu; Xing-Xing Fan; Jia-Xin Li; Wei-Yu Meng; Xuan-Run Wang; Tu-Liang Liang; Xiao-Xiang Guan; Hu-Dan Pan; Liang Liu; Xiao-Jun Yao; Qi Biao Wu; Elaine Lai-Han Leung
Source:
Phytomedicine 2022 v.95 pp. 153786
ISSN:
0944-7113
Subject:
Rheum officinale; Western blotting; antineoplastic activity; apoptosis; cell cycle; cell lines; cytotoxicity; emodin; enzyme inhibition; flow cytometry; lung neoplasms; lungs; mutants; phospholipases; reactive oxygen species; therapeutics
Abstract:
... Lung cancer has become the principal cause of cancer-related deaths. Emodin is a Chinese herb-derived compound extracted from the roots of Rheum officinale that exhibits numerous pharmacological characteristics. Secretory phospholipase A2-IIa (sPLA2-IIa) is overexpressed in cancers and plays an important role in cancer development.This study aims to investigate the anti-tumor mechanism of emodin i ...
DOI:
10.1016/j.phymed.2021.153786

20. Engineering Chemotherapeutic-Augmented Calcium Phosphate Nanoparticles for Treatment of Intraperitoneal Disseminated Ovarian Cancer

Author:
Miaojuan Qiu; Junzong Chen; Xiuyu Huang; Binbin Li; Shiqiang Zhang; Peng Liu; Qiang Wang; Zhi Rong Qian; Yihang Pan; Yu Chen; Jing Zhao
Source:
ACS applied materials & interfaces 2022 v.14 no.19 pp. 21954-21965
ISSN:
1944-8252
Subject:
antineoplastic activity; apoptosis; calcium; calcium phosphates; cell lines; doxorubicin; drug therapy; endoplasmic reticulum stress; humans; intraperitoneal injection; mitochondria; models; mortality; nanomedicine; ovarian neoplasms; toxicity
Abstract:
... Ovarian cancer is a common gynecologic malignancy with a high fatality rate. Intraperitoneal chemotherapy has been proved as an efficient clinical treatment for disseminated ovarian cancer. However, there are limitations for conventional small molecule drugs to achieve an ideal therapeutic effect. Herein, a synergistic treatment for intraperitoneally disseminated ovarian cancer was achieved by Arg ...
DOI:
10.1021/acsami.2c02552