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You searched for: Subject cell lines Remove constraint Subject: cell lines Subject term antineoplastic activity Remove constraint Subject term: antineoplastic activity Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. Antibiofilm and anticancer activities of unripe and ripe Azadirachta indica (neem) seed extracts

Author:
Kartik Chandra Guchhait; Tuhin Manna; Manas Barai; Monalisha Karmakar; Sourav Kumar Nandi; Debarati Jana; Aditi Dey; Suman Panda; Priyanka Raul; Anuttam Patra; Rittwika Bhattacharya; Subhrangsu Chatterjee; Amiya Kumar Panda; Chandradipa Ghosh
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 42
ISSN:
2662-7671
Subject:
Azadirachta indica; Staphylococcus aureus; Vibrio cholerae; acridine orange; alternative medicine; antibacterial properties; antibiotics; antineoplastic activity; bacterial culture; biofilm; breast neoplasms; cell lines; cytotoxicity; ethidium; fluorescence microscopy; gas chromatography; humans; mass spectrometry; methanol; minimum inhibitory concentration; multiple drug resistance; neoplasm cells; phthalic acid; toxicity testing; triazines
Abstract:
... BACKGROUND: Antibiotic resistances of pathogens and breast cancer warrant the search for new alternative strategies. Phytoextracts can eradicate microbe-borne diseases as well as cancer with lower side effects compared to conventional antibiotics. AIM: Unripe and ripe Azadirachta indica (neem) seed extracts were explored as potential antibiofilm and anticancer agents in combating multidrug-resista ...
DOI:
10.1186/s12906-022-03513-4

2. Antimicrobial activity, in vitro anticancer effect (MCF-7 breast cancer cell line), antiangiogenic and immunomodulatory potentials of Populus nigra L. buds extract

Author:
Brigitta Kis; Ioana Zinuca Pavel; Stefana Avram; Elena Alina Moaca; Martina Herrero San Juan; Anja Schwiebs; Heinfried H. Radeke; Delia Muntean; Zorita Diaconeasa; Daliana Minda; Camelia Oprean; Florina Bojin; Cristina Adriana Dehelean; Codruta Soica; Corina Danciu
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 74
ISSN:
2662-7671
Subject:
Populus nigra; alternative medicine; antimicrobial properties; antineoplastic activity; antioxidant activity; apoptosis; breast neoplasms; cell cycle checkpoints; cell lines; cell viability; chemical constituents of plants; chorioallantoic membrane; dose response; humans; immunomodulators; interleukin-12; interleukin-23; neoplasm cells; toxicity; Romania
Abstract:
... PURPOSE: The aim of this study was to evaluate the antioxidant potential, antimicrobial activity, the in vitro anticancer effect (tested on MCF-7 breast cancer cell line), as well as the antiangiogenic and immunomodulatory potential of Populus nigra L. bud (Pg) extract collected from the western part of Romania. RESULTS: Populus nigra L. bud extract presents an important antioxidant activity, due ...
DOI:
10.1186/s12906-022-03526-z

3. Arborinine suppresses ovarian cancer development through inhibition of LSD1

Author:
Nan Li; Liang Yang; Hongling Zuo
Source:
Life sciences 2022 v.291 pp. 120275
ISSN:
0024-3205
Subject:
Western blotting; antineoplastic activity; antineoplastic agents; cancer therapy; carcinogenesis; cell lines; cell movement; cell proliferation; cytotoxicity; dose response; drug therapy; epithelium; females; gene expression; mice; neoplasm cells; ovarian neoplasms; paclitaxel; toxicity testing
Abstract:
... Epithelial ovarian carcinoma is the most lethal female reproductive malignancy in the world. Paclitaxel and carboplatin are generally the first-line treatment drugs for ovarian cancer patients, but numerous patients may develop chemotherapy resistance. Thus, it is urgent to identify novel drugs for ovarian cancer treatment. Arborinine has been known as a broad-spectrum anti-tumor agent due to it p ...
DOI:
10.1016/j.lfs.2021.120275

4. Assessing the Protective Effect of Moringa oleifera Extract against Bone Metastasis: An In Vitro Simulated Digestion Approach

Author:
Kinjal P. Bhadresha; Nayan K. Jain; Rakesh M. Rawal
Source:
Nutrition and cancer 2022 v.74 no.3 pp. 1023-1036
ISSN:
1532-7914
Subject:
Moringa oleifera; antineoplastic activity; antioxidant activity; antioxidants; apoptosis; bioactive compounds; bioavailability; cell lines; cell viability; cytotoxicity; digestion; flavonoids; gene expression; glutathione; interphase; metastasis; polyphenols; prostatic neoplasms; protective effect; spectral analysis
Abstract:
... Moringa oleifera possesses numerous advantageous effects like anti-microbial, antioxidant, and anti-inflammatory, leaves contain a high multiplicity of the bioactive compound; however, little is identified about its bioaccessibility. The objective of this study was to assess the bioefficacy, bioaccessible and anticancer activity of Moringa oleifera in a PC3 cell line before and after simulated in ...
DOI:
10.1080/01635581.2021.1933099

5. Comparative Evaluation of the Potential Antitumor of Helleborus purpurascens in Skin and Breast Cancer

Author:
Ciprian Nicolae Pilut; Aniko Manea; Ioana Macasoi; Amadeus Dobrescu; Doina Georgescu; Roxana Buzatu; Alin Faur; Stefania Dinu; Doina Chioran; Iulia Pinzaru; Monica Hancianu; Cristina Dehelean; Daniel Malița
Source:
Plants 2022 v.11 no.2 pp. -
ISSN:
2223-7747
Subject:
Helleborus; antineoplastic activity; antioxidant activity; apoptosis; ascorbic acid; breast neoplasms; cancer therapy; cell lines; cytotoxicity; epicatechin; kaempferol; neoplasm cells; quercetin
Abstract:
... In the field of oncology, the plant kingdom has an inexhaustible supply of bioactive compounds. Phytochemical compounds isolated from Helleborus species have been found to be useful in various chronic diseases. This has brought Helleborus to the attention of medical researchers. H. purpurascens is a plant characteristic of the Carpathian area, known since ancient times for its beneficial effects. ...
DOI:
10.3390/plants11020194

6. Complexation-induced nanoarchitectonics of sulfonate cailx[4]resorcinol substituted at the upper rim by N-methyl-d-glucamine fragments: Morphological transition and in vitro anticancer activity

Author:
Nadezda E. Kashapova; Ruslan R. Kashapov; Albina Y. Ziganshina; Syumbelya K. Amerhanova; Anna P. Lyubina; Alexandra D. Voloshina; Vadim V. Salnikov; Lucia Y. Zakharova
Source:
Colloids and surfaces 2022 v.643 pp. 128796
ISSN:
0927-7757
Subject:
antineoplastic activity; cell lines; copper; cytotoxicity; ligands; liver; neoplasms; resorcinol; sulfonates
Abstract:
... Complexes of various nitrogen-containing ligands with transition metals are known for their anticancer activity. At the same time, the shape of aggregates of these complexes can have a significant effect on cytotoxicity and selectivity of action in tumor cells, however, this issue has received insufficient attention in the literature. In this work, the selective binding ability of sulfonate calix[ ...
DOI:
10.1016/j.colsurfa.2022.128796

7. Cytotoxic activity of crude extracts and fractions of African peach (nauclea latifolia smith) stem bark on two cancer cell lines

Author:
Oluwakemi Charles-Okhe; Michael A. Odeniyi; Titilayo O. Fakeye; Omonike O. Ogbole; Toluwanimi E. Akinleye; Adekunle J. Adeniji
Source:
Phytomedicine plus 2022 v.2 no.1 pp. 100212
ISSN:
2667-0313
Subject:
Cercopithecus aethiops; Sarcocephalus latifolius; antineoplastic activity; bark; bark extracts; breast neoplasms; cell lines; colorimetry; cytotoxicity; drug therapy; ethyl acetate; fractionation; hexane; kidneys; liquid chromatography; methanol; neoplasm cells; peaches; skeletal muscle; vincristine
Abstract:
... The purpose of this research work is to investigate and establish the anticancer (cytotoxic) properties of African peach (Nauclea latifolia) stem bark extract and fractions on breast cancer cell lines (MCF-7), skeletal muscle cancer (RD) cell lines and to determine the selectivity index (SI) on normal African green monkey kidney cell lines (Vero). Crude extract and fractions obtained from acid-bas ...
DOI:
10.1016/j.phyplu.2021.100212

8. Density functional theoretical study, spectroscopic characterization and molecular docking of the diuretic drug, spironolactone, adsorbed on AuNPs surface and in-vitro studies based on anticancer activity studies against A549 lung cancer cell line

Author:
V. Shyni; D.R. Leenaraj; Reena Ittyachan; Rejeena V. Rajan; G.J. Shyju; Lynnette Joseph; D. Sajan
Source:
Colloids and surfaces 2022 v.646 pp. 128255
ISSN:
0927-7757
Subject:
antineoplastic activity; cell lines; density functional theory; drugs; electron transfer; energy; gold; hydrogen; lung neoplasms; neoplasm cells; spectral analysis; spironolactone; therapeutics; toxicity testing; transmission electron microscopes
Abstract:
... In this study, the geometry, intramolecular charge transfer interactions, and harmonic vibrational frequencies of the diuretic drug, Spironolactone (SPL) and SPL adsorbed on gold nanoparticle (SPLA molecule) were investigated with the help of density functional theory method. Both molecules were found to be stabilized by intramolecular hydrogen bonds C₇-H₃₇. O₂₇ and C₁₆-H₄₇. O₂, as well as intramo ...
DOI:
10.1016/j.colsurfa.2022.128255

9. Diadema setosum: isolation of bioactive secondary metabolites with cytotoxic activity toward human cervical cancer

Author:
Fahd M. Abdelkarem; Ezz-Eldin K. Desoky; Alaa M. Nafady; Ahmed E. Allam; Aldoushy Mahdy; Ahmed Ashour; Kuniyoshi Shimizu
Source:
Natural product research 2022 v.36 no.4 pp. 1118-1122
ISSN:
1478-6427
Subject:
antineoplastic activity; cell lines; chromatography; colorimetry; cytotoxicity; ethyl acetate; humans; neoplasm cells; nuclear magnetic resonance spectroscopy; research; secondary metabolites; uterine cervical neoplasms
Abstract:
... In our promising project toward discovery of secondary metabolites with potential anticancer activity against human cervical cancer, seven marine organisms were screened for their cytotoxic activity against HeLa cancer cell line using MTT colorimetric assay. The crude extract of the outer shell of Diadema setosum showed promising activity with 88.02% inhibition at a concentration 250 µg/ml. Chroma ...
DOI:
10.1080/14786419.2020.1855162

10. Ecofriendly Synthesis of Biosynthesized Copper Nanoparticles with Starch-Based Nanocomposite: Antimicrobial, Antioxidant, and Anticancer Activities

Author:
Mohamed Hasanin; Mohamed A. Al Abboud; Mohamed M. Alawlaqi; Tarek M. Abdelghany; Amr H. Hashem
Source:
Biological trace element research 2022 v.200 no.5 pp. 2099-2112
ISSN:
0163-4984
Subject:
Aspergillus niger; Bacillus subtilis; Candida albicans; Escherichia coli; Fourier transform infrared spectroscopy; X-ray diffraction; antifungal properties; antineoplastic activity; antioxidant activity; antioxidants; ascorbic acid; biosynthesis; cell lines; copper nanoparticles; energy-dispersive X-ray analysis; nanocomposites; research; starch; trace elements; transmission electron microscopes; ultraviolet-visible spectroscopy
Abstract:
... In recent years, polysaccharides-based nanocomposites have been used for biomedical applications. In the current study, a nanocomposite based on myco-synthesized copper nanoparticles (CuNPs) and starch was prepared. The prepared nanocomposite was fully characterized using UV–visible spectroscopy (UV–vis), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), scanning electron mi ...
DOI:
10.1007/s12011-021-02812-0

11. Emodin induces apoptosis and suppresses non-small-cell lung cancer growth via downregulation of sPLA2-IIa

Author:
Fang-Yuan Zhang; Run-Ze Li; Cong Xu; Xing-Xing Fan; Jia-Xin Li; Wei-Yu Meng; Xuan-Run Wang; Tu-Liang Liang; Xiao-Xiang Guan; Hu-Dan Pan; Liang Liu; Xiao-Jun Yao; Qi Biao Wu; Elaine Lai-Han Leung
Source:
Phytomedicine 2022 v.95 pp. 153786
ISSN:
0944-7113
Subject:
Rheum officinale; Western blotting; antineoplastic activity; apoptosis; cell cycle; cell lines; cytotoxicity; emodin; enzyme inhibition; flow cytometry; lung neoplasms; lungs; mutants; phospholipases; reactive oxygen species; therapeutics
Abstract:
... Lung cancer has become the principal cause of cancer-related deaths. Emodin is a Chinese herb-derived compound extracted from the roots of Rheum officinale that exhibits numerous pharmacological characteristics. Secretory phospholipase A2-IIa (sPLA2-IIa) is overexpressed in cancers and plays an important role in cancer development.This study aims to investigate the anti-tumor mechanism of emodin i ...
DOI:
10.1016/j.phymed.2021.153786

12. Engineering Chemotherapeutic-Augmented Calcium Phosphate Nanoparticles for Treatment of Intraperitoneal Disseminated Ovarian Cancer

Author:
Miaojuan Qiu; Junzong Chen; Xiuyu Huang; Binbin Li; Shiqiang Zhang; Peng Liu; Qiang Wang; Zhi Rong Qian; Yihang Pan; Yu Chen; Jing Zhao
Source:
ACS applied materials & interfaces 2022 v.14 no.19 pp. 21954-21965
ISSN:
1944-8252
Subject:
antineoplastic activity; apoptosis; calcium; calcium phosphates; cell lines; doxorubicin; drug therapy; endoplasmic reticulum stress; humans; intraperitoneal injection; mitochondria; models; mortality; nanomedicine; ovarian neoplasms; toxicity
Abstract:
... Ovarian cancer is a common gynecologic malignancy with a high fatality rate. Intraperitoneal chemotherapy has been proved as an efficient clinical treatment for disseminated ovarian cancer. However, there are limitations for conventional small molecule drugs to achieve an ideal therapeutic effect. Herein, a synergistic treatment for intraperitoneally disseminated ovarian cancer was achieved by Arg ...
DOI:
10.1021/acsami.2c02552

13. Evaluation of anti-proliferative activity of Eryngium caucasicum on melanoma cancer cells

Author:
Haleh Forouhandeh; Zahra Rezaei Param; Ommoleila Molavi; Parina Asgharian; Vahideh Tarhriz
Source:
BMC complementary medicine and therapies 2022 v.22 no.1 pp. 134
ISSN:
2662-7671
Subject:
Eryngium caeruleum; alternative medicine; analgesics; antineoplastic activity; antioxidants; apoptosis; cell lines; cytotoxicity; fractionation; hexane; melanoma; methanol; methylene chloride; necrosis; neoplasm cells
Abstract:
... BACKGROUND: The genus Eryngium is a member of the Apiaceae family that has shown different pharmacological effects mainly including anti-inflammatory, analgesic, anti-cancer, hepatoprotective, and anti-oxidant. Previous research on the anti-cancer activity of Eryngium in some cancer cell lines has led us to explore the anti-proliferative activity of E. caucasicum in the B16F10 cell line. OBJECTIVE ...
DOI:
10.1186/s12906-022-03618-w

14. Evaluation of anti-tumor effect of the exopolysaccharide from new cold-adapted yeast, Rhodotorula mucilaginosa sp. GUMS16 on chronic myeloid leukemia K562 cell line

Author:
Setare Kheyrandish; Amirhossein Rastgar; Masoud Hamidi; Seyed Mehdi Sajjadi; Gholamreza Anani Sarab
Source:
International journal of biological macromolecules 2022 v.206 pp. 21-28
ISSN:
0141-8130
Subject:
Rhodotorula rubra; antineoplastic activity; antioxidants; apoptosis; biopolymers; cell cycle; cell lines; cytotoxicity; exopolysaccharides; gene expression; inhibitory concentration 50; lactic acid; myeloid leukemia; neoplasm cells; quantitative polymerase chain reaction; viability; yeasts
Abstract:
... Recently, the development and application of fungal exopolysaccharides (EPS) as natural biopolymers are on the rise. The present study is based on the investigation of possible antiproliferative and antioxidant activities of EPS from the Rhodotorula mucilaginosa sp. GUMS16 on BCR-ABL positive cells (K562). The cytotoxicity, colony formation assays lactate and dehydrogenase (LDH) activity were perf ...
DOI:
10.1016/j.ijbiomac.2022.02.113

15. FNC inhibits non-small cell lung cancer by activating the mitochondrial apoptosis pathway

Author:
Xiang Jing; Shuai Niu; Yi Liang; Huiping Chen; Ning Wang; Youmei Peng; Fang Ma; Wanying Yue; Qingduan Wang; Junbiao Chang; Yi Zhang; Yan Zhang
Source:
Genes & genomics 2022 v.44 no.1 pp. 123-131
ISSN:
1976-9571
Subject:
Western blotting; antineoplastic activity; apoptosis; cadherins; cell adhesion; cell lines; cell movement; cell viability; cytosine; dose response; flow cytometry; genomics; immunohistochemistry; lung neoplasms; metastasis; mice; mitochondria; nucleosides; protein synthesis; toxicity; xenotransplantation
Abstract:
... BACKGROUND: Previously, we published that 4′-azid-2′-deoxy-2′-fluorarabinoside (FNC), a novel cytosine nucleoside analog, has good anti-viral and anti-tumor activity. OBJECTIVE: This study aimed to further explore the role and molecular mechanism of FNC in non-small cell lung cancer (NSCLC). METHODS: FNC was tested in the NSCLC H460 cell line, the Lewis mouse model, and the H460 cell xenograft mod ...
DOI:
10.1007/s13258-021-01179-9

16. Gas chromatographic-mass spectrometric analysis, antioxidant, antiproliferative and antibacterial activities of the essential oil of Prangospabularia

Author:
Javid A. Banday; Zubaid-ul-khazir Rather; Gulam N. Yatoo; Mohammad Asif Hajam; Sajad A. Bhat; Vichangal Pridiuldi Santhanakrishnan; Alia Farozi; Manzoor A. Rather; Shahid Rasool
Source:
Microbial pathogenesis 2022 v.166 pp. 105540
ISSN:
0882-4010
Subject:
Escherichia coli; Micrococcus; Prangos pabularia; acetates; acetone; adenocarcinoma; agar; aldehydes; antibacterial properties; antineoplastic activity; breasts; cell lines; cytotoxicity; epithelium; essential oils; free radicals; humans; lungs; oils; pathogenesis; streptomycin; sulfates; toxicity testing; uterine cervical neoplasms; India
Abstract:
... The essential oil composition of the shoot parts of Prangos pabularia, growing in Drass area of Ladakh, India, along with its antioxidant, antibacterial and anticancer activity, is reported for the first time. Gas chromatography coupled with mass spectrometry (GC-MS) revealed the presence of 31 constituents, representing 97.342% of the total essential oil. The major constituents of essential oil w ...
DOI:
10.1016/j.micpath.2022.105540

17. Green synthesis of silver nanoparticles using Rhodiola imbricata and Withania somnifera root extract and their potential catalytic, antioxidant, cytotoxic and growth-promoting activities

Author:
Sahil Kapoor; Hemant Sood; Shweta Saxena; Om Prakash Chaurasia
Source:
Bioprocess and biosystems engineering 2022 v.45 no.2 pp. 365-380
ISSN:
1615-7591
Subject:
Hordeum vulgare; Rhodiola; Withania somnifera; agricultural industry; antineoplastic activity; antineoplastic agents; antioxidant activity; antioxidants; bioprocessing; carotenoids; cell lines; cell viability; chlorophyll; cytotoxicity; dose response; germination; nanosilver; neoplasm cells; p-nitrophenol; photosynthesis; pollutants; pollution; remediation; root extracts; silver nitrate; sustainable technology; zeta potential
Abstract:
... This study presents the development of a sustainable production process of environmentally benign silver nanoparticles (AgNPs) from aqueous root extract of Rhodiola imbricata (RI) and Withania somnifera (WS) for mitigating environmental pollution and investigating their potential applications in agriculture and biomedical industry. RIWS-AgNPs were characterized using several analytical techniques ...
DOI:
10.1007/s00449-021-02666-9

18. In vitro anticancer activity of curcumin loaded chitosan nanoparticles (CLCNPs) against vero cells

Author:
Deepika; Minakshi Prasad; Raj Kumar Salar
Source:
Pharmacological research 2022 pp. 100116
ISSN:
2667-1425
Subject:
Fourier transform infrared spectroscopy; antineoplastic activity; antineoplastic agents; cell lines; chitosan; curcumin; differential thermal analysis; electron microscopy; gelation; pollution; research; temperature; thermogravimetry; ultraviolet-visible spectroscopy
Abstract:
... The global burden of cancer is rising due to increasing pollution, change in life styles and dietary habits rendering it as one of the leading cause of deaths worldwide. Poor availability of anticancer drugs in affected tissues necessitates higher doses and longer treatment regimens to treat most cancers. In the present investigation curcumin, an anticancer drug was loaded in chitosan nanoparticle ...
DOI:
10.1016/j.prmcm.2022.100116

19. Isolation of Sesquiterpene Lactones and the Antioxidant and Anticancer Activities of Crude Extracts from Cyanthillium cinereum

Author:
J. Dharani; S. Ravi
Source:
Chemistry of natural compounds 2022 v.58 no.1 pp. 40-46
ISSN:
0009-3130
Subject:
Cyanthillium cinereum; DNA replication; antineoplastic activity; antioxidant activity; antioxidants; cell lines; cytotoxicity; interphase; sesquiterpenoid lactones
Abstract:
... Three sesquiterpene lactones has been isolated from Cyanthillium cinereum (L.) H. Rob. by bioactivity guided assay and characterized by spectral methods as compounds 1, 2, and 3. The in vitro anticancer activity was tested against 786-O, MCF-7, and K562 cells by the MTT assay. Compound 1 showed IC₅₀ values of 12.5 and 10.4 μg/mL against 786-O cell line after 48 and 72 h, respectively, and matches ...
DOI:
10.1007/s10600-022-03593-1

20. Lead Borate Nanoparticles Induce Apoptotic Gene Activity in P53 Mutant Cancer Cells

Author:
Taha Bartu Hayal; Oğuz Kaan Kırbaş; Batuhan Turhan Bozkurt; Pakize Neslihan Taşlı; Berna Bülbül; Seda Beyaz; Fikrettin Şahin
Source:
Biological trace element research 2022 v.200 no.2 pp. 574-581
ISSN:
0163-4984
Subject:
antineoplastic activity; apoptosis; borates; breast neoplasms; cell lines; cell viability; lead; lead nitrate; mutants; mutation; neoplasm cells; quantitative polymerase chain reaction; research; therapeutics; toxicity; trace elements; tumor suppressor protein p53
Abstract:
... Cancer is a complex and multistage disease that causes suffering worldwide. Several mutations in tumor suppressor proteins are mostly responsible for tumorigenic development. Thus, determination of the mutations and developing a mutation targeted therapy are crucial in order to cure cancer. Moreover, since healthy cells do not have mutations in their tumor suppressor genes, mutation-specific treat ...
DOI:
10.1007/s12011-021-02696-0