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You searched for: Subject cell membranes Remove constraint Subject: cell membranes Subject term adenosine Remove constraint Subject term: adenosine Subject term antagonists Remove constraint Subject term: antagonists Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
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1. Adenosine A₂B receptor antagonist suppresses differentiation to regulatory T cells without suppressing activation of T cells

Author:
Hiroko Nakatsukasa; Mitsutoshi Tsukimoto; Hitoshi Harada; Shuji Kojima
Source:
Biochemical and biophysical research communications 2011 v.409 no.1 pp. 114-119
ISSN:
0006-291X
Subject:
T-lymphocytes; adenosine; antagonists; cell membranes; immunity; interleukin-10; mice; receptors
Abstract:
... Extracellular adenosine activates P1 receptors (A₁, A₂A, A₂B, A₃) on cellular membranes. Here, we investigated the involvement of P1 receptor-mediated signaling in differentiation to regulatory T cells (Treg). Treg were induced in vitro by incubating isolated CD4⁺CD62L⁺ naïve murine T cells under Treg-skewing conditions. Antagonists of A₁ and A₂B receptors suppressed the expression of Foxp3, a spe ...
DOI:
10.1016/j.bbrc.2011.04.125

2. Characteristics of taurine release induced by free radicals in mouse hippocampal slices

Author:
P. Saransaari; S. S. Oja
Source:
Amino acids 2004 v.26 no.1 pp. 91-98
ISSN:
0939-4451
Subject:
adenosine; adults; agonists; antagonists; cell membranes; glutamic acid; hippocampus; hydrogen peroxide; hydroxylamine; ischemia; mice; neuroprotective effect; nitric oxide; receptors; taurine; transporters; tritium
Abstract:
... The release of the inhibitory neuromodulator taurine in the hippocampus is markedly enhanced under various neural cell-damaging conditions, including ischemia and exposure to free radicals. The properties and regulation of the release evoked by a medium containing free radicals was investigated in hippocampal slices from adult (3-month-old) and developing (7-day-old) mice, using a superfusion syst ...
DOI:
10.1007/s00726-003-0004-1

3. Possible therapeutic benefits of adenosine-potentiating drugs in reducing age-related degenerative disease in dogs and cats

Author:
Scaramuzzi, R.J.; Baker, D.J.
Source:
Journal of veterinary pharmacology and therapeutics 2003 v.26 no.5 pp. 327-335
ISSN:
0140-7783
Subject:
adenosine; central nervous system; smooth muscle; antagonists; cats; dogs; drugs; skeletal muscle; gonads; spaying; heart; cell membranes; pets; quality of life; immune system; receptors; agonists; enzyme inhibition; castration
Abstract:
... Adenosine is a ubiquitous, biologically important molecule that is a precursor of other biologically active molecules. It also is a component of some co-factors and has distinct physiological actions in its own right. Levels are maintained by synthesis from dietary precursors and re-cycling. The daily turnover of adenosine is very high. Adenosine can act either as a hormone by binding to adenosine ...
DOI:
10.1046/j.1365-2885.2003.00527.x
PubMed:
14633184