You searched for:
Subject
chemical structure
Remove constraint Subject: chemical structure
Subject
lignans
Remove constraint Subject: lignans
PubAg
Main content area
Limit your search
- chemical structure[remove]352
- lignans[remove]352
- spectral analysis194
- medicinal plants89
- chemical constituents of plants81
- more Subject »
Search
352 Search Results
« Previous |
1 - 100 of 352
|
Next »
Search Results
- Author:
- Buket Bozkurt; Gulen Irem Kaya; Mustafa Ali Onur; Nehir Unver-Somer
- Source:
- South African journal of botany 2021 v.136 pp. 65-69
- ISSN:
- 0254-6299
- Subject:
- Alzheimer disease; Galanthus; acetylcholinesterase; bioactive properties; bulbs; chemical composition; chemical structure; cholinesterase; cholinesterase inhibitors; indigenous species; isoquinoline alkaloids; lignans; ornamental value; plant extracts; research
- Abstract:
- ... Amaryllidaceae family, consisting of economically important plants with ornamental value, is very well-known for its isoquinoline alkaloids with variable biological activities and chemical structures. Among these alkaloids, an effective acetylcholinesterase inhibitor galanthamine, is prescribed widely in the treatment of Alzheimer's disease. Plants of the Amaryllidaceae family are therefore, subje ...
- DOI:
- 10.1016/j.sajb.2020.09.012
- https://doi.org/10.1016/j.sajb.2020.09.012
- Author:
- Kai Yang; Tian-Rui Xu; Yan-Hong Fu; Ming Cai; Qi-Le Xia; Rong-Fa Guan; Xian-Guo Zou; Pei-Long Sun
- Source:
- Food research international 2021 v.139 pp. 109907
- ISSN:
- 0963-9969
- Subject:
- Fourier transform infrared spectroscopy; amino acid composition; chemical structure; food research; lignans; nutritive value; oil crops; sesame cake; solubility; thermal stability; ultrasonics
- Abstract:
- ... Sesame is an oil crop with high nutritional value. Protein is one of the main ingredients of sesame, however research on protein of cold-pressed sesame cake is limited. This study aimed to investigate the effects of ultrasonic pre-treatment (UPT) on physicochemical properties of proteins (yield, solubility, amino acid composition, surface properties, structural and thermal stability) extracted fro ...
- DOI:
- 10.1016/j.foodres.2020.109907
- https://doi.org/10.1016/j.foodres.2020.109907
- Author:
- Soyoung Park; Seungsu Kim; Dongyun Shin
- Source:
- Phytochemistry reviews 2021 v.20 no.5 pp. 1033-1054
- ISSN:
- 1568-7767
- Subject:
- antiretroviral agents; chemical structure; cytotoxicity; glycosylation; lactones; lignans; oxidation; plant biochemistry
- Abstract:
- ... Natural arylnaphthalene lactones are representative lignans that are found in various dietary and medicinal plants. Their unique structural features and significant pharmacological activity have attracted considerable attention from both synthetic and medicinal chemists. Owing to their unique structural features such as relative rigid tetracyclic skeleton, structural diversity of more than five su ...
- DOI:
- 10.1007/s11101-020-09735-z
- https://doi.org/10.1007/s11101-020-09735-z
4. Chemical constituents of the roots of Scorzonera divaricata and their chemotaxonomic significance
- Author:
- Xian-Hua Meng; Yong-Jin Yang; Yuan Gong; Ying Zhu
- Source:
- Biochemical systematics and ecology 2020 v.93 pp. 104135
- ISSN:
- 0305-1978
- Subject:
- Scorzonera divaricata; benzene derivatives; caffeic acid; chemical composition; chemical structure; chemotaxonomy; electrospray ionization mass spectrometry; lignans; nuclear magnetic resonance spectroscopy; phenylpropanoids; phytochemicals; roots; scopoletin; sterols
- Abstract:
- ... The phytochemical study of the roots of Scorzonera divaricata Turcz led to the isolation of 27 compounds, including eight sterols (1–8), one lignan (9), two cumarins (10, 11), five phenylpropanoids (12–16), six benzene derivatives (17–22), methyl-β-D-fructofuranoside (23), monolinolein (24), and three aliphatic acids (25–27). The structures of isolated compounds were identified using NMR and ESI-M ...
- DOI:
- 10.1016/j.bse.2020.104135
- https://doi.org/10.1016/j.bse.2020.104135
- Author:
- Weichen Xiong; Yanfang Yang; Yiyi Xiong; Bo Liu; Zhoutao Xie; Hezhen Wu
- Source:
- Chemistry of natural compounds 2020 v.56 no.1 pp. 50-52
- ISSN:
- 0009-3130
- Subject:
- Justicia procumbens; chemical structure; lignans; spectroscopy
- Abstract:
- ... A new neolignan, named (7′S,8′R)-5,3′-dimethoxy-4,4′,9′-trihydroxy-2-8′,9-O-7′-neolignan (1), along with two known compounds, secoisolariciresinol (2) and lariciresinol (3), was isolated from the whole plant of Justicia procumbens L. The structure of 1 was established by spectroscopic methods, and the absolute configuration was determined using circular dichroic (CD) spectra. ...
- DOI:
- 10.1007/s10600-020-02941-3
- https://doi.org/10.1007/s10600-020-02941-3
- Author:
- Dunja Šamec; Erna Karalija; Ivana Šola; Valerija Vujčić Bok; Branka Salopek-Sondi
- Source:
- Plants 2021 v.10 no.1 pp. -
- ISSN:
- 2223-7747
- Subject:
- abiotic stress; bioactive properties; biodiversity; chemical structure; crop production; drought; flavonoids; heavy metals; light; lignans; metabolites; phenolic acids; plant growth; polymerization; polyphenols; stilbenoids; stress response; temperature
- Abstract:
- ... Abiotic stressors such as extreme temperatures, drought, flood, light, salt, and heavy metals alter biological diversity and crop production worldwide. Therefore, it is important to know the mechanisms by which plants cope with stress conditions. Polyphenols, which are the largest group of plant-specialized metabolites, are generally recognized as molecules involved in stress protection in plants. ...
- DOI:
- 10.3390/plants10010118
- https://doi.org/10.3390/plants10010118
- Author:
- Rui Zhan; Dashan Li; Yuan-Lie Liu; Xiao-Yan Xie; Lei Chen; Li-Dong Shao; Wen-Jing Wang; Ye-Gao Chen
- Source:
- Tetrahedron 2020 v.76 no.40 pp. 131494
- ISSN:
- 0040-4020
- Subject:
- X-ray diffraction; acetone; bioactive properties; bioassays; biomimetic synthesis; branches; chemical reactions; chemical structure; circular dichroism spectroscopy; crystallography; enzyme inhibition; inducible nitric oxide synthase; inhibitory concentration 50; leaves; lignans; nitric oxide; phytochemicals; spectral analysis
- Abstract:
- ... Bioactivity-guided phytochemical investigation on 70% aqueous acetone extracts of the twigs and leaves of Horsfieldia kingii led to the isolation of two novel cyclic diarylpropanes (1 and 2) bearing a 2,3-dihydro-1H-indene core, one new diarylpropane (3), six known diarylpropanes (4–9), one flavanol (10), and seven lignans (11–17). Their structures were determined by extensive spectroscopic analys ...
- DOI:
- 10.1016/j.tet.2020.131494
- https://doi.org/10.1016/j.tet.2020.131494
- Author:
- Ming-Zao Zhao; Yi Shen; Wei Xu; Ying-Zhi Chen; Chao-Jiang Xiao; Bei Jiang
- Source:
- Journal of Asian natural products research 2020 v.22 no.6 pp. 594-600
- ISSN:
- 1477-2213
- Subject:
- Actinomyces viscosus; Astragalus; Candida albicans; Escherichia coli; Proteus vulgaris; Pseudomonas aeruginosa; Salmonella Typhi; Shigella dysenteriae; Staphylococcus aureus; Streptococcus mutans; antibacterial properties; antifungal properties; chemical structure; glycosides; lignans; methanol; nuclear magnetic resonance spectroscopy; plant extracts; roots; spectral analysis
- Abstract:
- ... A new lignan glycoside, astrayunoside A (1), along with eight known compounds (2–9), were obtained from the methanol extract of roots of Astragalus yunnanensis. All the compounds were obtained from A. yunnanensis for the first time. Their structures were elucidated by extensive spectroscopic analysis (1D and 2D-NMR, MS, UV, CD, and IR). The weak antibacterial activities of the crude extracts of A. ...
- DOI:
- 10.1080/10286020.2019.1607840
- https://doi.org/10.1080/10286020.2019.1607840
- Author:
- Mengyue Wang; Lili Wu; Hao Zhang; Dun Zhu Ci Ren; Tonghua Liu; Xiaobo Li
- Source:
- Chemistry of natural compounds 2019 v.55 no.5 pp. 839-842
- ISSN:
- 0009-3130
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Urtica; antioxidants; chemical structure; flavonoids; flowers; lignans; median effective concentration; phenolic acids; spectral analysis
- Abstract:
- ... Eleven compounds (1–11), including two new compounds (1, 2), were isolated from the antioxidant portion of the alcoholic extract of Urtica fissa flowers. Their chemical structures were elucidated from extensive spectroscopic analysis. The results of activity evaluation indicated that some compounds of phenolic acids (3, 4), flavonoids (7, 9, 10), and lignans (1, 6) possess significant activities o ...
- DOI:
- 10.1007/s10600-019-02827-z
- https://doi.org/10.1007/s10600-019-02827-z
- Author:
- Wanchun Chu; Pinyi Gao; Lingzhi Li
- Source:
- Biochemical systematics and ecology 2019 v.86 pp. 103923
- ISSN:
- 0305-1978
- Subject:
- Crataegus pinnatifida; carbon; chemical composition; chemical structure; chemotaxonomy; coumaric acids; flavonoids; leaves; lignans; nuclear magnetic resonance spectroscopy; spectral analysis; stable isotopes; triterpenoids
- Abstract:
- ... The phytochemical investigations on the leaves of Crataegus pinnatifida led to the isolation of 20 compounds, including seven triterpenoids (1-7), three hydroxycinnamic acids (8-10), three lignans (11-13) and seven flavonoids (14-20). All chemical structures were established on the basis of NMR (1H NMR, 13C NMR) spectroscopic data. Meanwhile, compounds 3-12 are reported for the first time from Crat ...
- DOI:
- 10.1016/j.bse.2019.103923
- https://doi.org/10.1016/j.bse.2019.103923
- Author:
- Rongshen Wang; Jinfeng Sun; Chao Ye; Jiaming Wang; Tieqiang Zong; Wei Zhou; Gao Li
- Source:
- Biochemical systematics and ecology 2020 v.89 pp. 103999
- ISSN:
- 0305-1978
- Subject:
- Sanguisorba officinalis; chemical composition; chemical structure; chemotaxonomy; flavonoids; glycosides; lignans; monoterpenoids; phenols; roots; spectral analysis; triterpenoids
- Abstract:
- ... Phytochemical investigation of the roots of Sanguisorba officinalis L. led to the isolation of thirty-eight compounds, including seventeen triterpenoids (1–17), six monoterpenoid glycosides (18–23), six flavonoids (24–29), six phenols (30–35), two glycosides (36–37), and one lignan (38). The chemical structures of these compounds were elucidated on the basis of spectral data and by comparisons of ...
- DOI:
- 10.1016/j.bse.2019.103999
- https://doi.org/10.1016/j.bse.2019.103999
- Author:
- Eiichiro Ono; Toshiyuki Waki; Daiki Oikawa; Jun Murata; Akira Shiraishi; Hiromi Toyonaga; Masako Kato; Naoki Ogata; Seiji Takahashi; Masa‐atsu Yamaguchi; Manabu Horikawa; Toru Nakayama
- Source:
- plant journal 2020 v.101 no.5 pp. 1221-1233
- ISSN:
- 0960-7412
- Subject:
- Sesamum indicum; biochemical pathways; biosynthesis; catalytic activity; chemical structure; glucosylation; glucosyltransferases; hydrophobicity; lignans; metabolites; mutants; phylogeny; seeds; sugars; two hybrid system techniques; water solubility
- Abstract:
- ... Sesame (Sesamum indicum) seeds contain a large number of lignans, phenylpropanoid‐related plant specialized metabolites. (+)‐Sesamin and (+)‐sesamolin are major hydrophobic lignans, whereas (+)‐sesaminol primarily accumulates as a water‐soluble sesaminol triglucoside (STG) with a sugar chain branched via β1→2 and β1→6‐O‐glucosidic linkages [i.e. (+)‐sesaminol 2‐O‐β‐d‐glucosyl‐(1→2)‐O‐β‐d‐glucoside ...
- DOI:
- 10.1111/tpj.14586
- https://doi.org/10.1111/tpj.14586
- Author:
- Yeong-Geun Lee; Kyeong-Hwa Seo; Jung Eun Gwag; Hyoung-Geun Kim; Jung-Hwan Ko; Dae Young Lee; Nam-In Baek
- Source:
- Chemistry of natural compounds 2019 v.55 no.3 pp. 432-434
- ISSN:
- 0009-3130
- Subject:
- Forsythia viridissima var. koreana; chemical structure; flowers; lignans
- Abstract:
- ... A new lignan (1) was isolated from the flowers of Forsythia koreana along with one known lignan, 4,4′-di-O-β-D-glucosylpinoresinol (2). The molecular structures were determined using spectral methods. These compounds were isolated from F. koreana flowers for the first time. ...
- DOI:
- 10.1007/s10600-019-02707-6
- https://doi.org/10.1007/s10600-019-02707-6
- Author:
- Padam Kumar; Kapil Dev; Khushbu Sharma; Mahendra Sahai; Rakesh Maurya
- Source:
- Natural product research 2019 v.33 no.2 pp. 233-238
- ISSN:
- 1478-6427
- Subject:
- Cissus quadrangularis; chemical constituents of plants; chemical structure; glycosides; lignans; mass spectrometry; nuclear magnetic resonance spectroscopy; spectral analysis; stems
- Abstract:
- ... Phytochemical investigation of Cissus quadrangularis stems led to the isolation of one new phenolic glycoside (1) and two new lignan glycosides (7 & 8) along with twelve known compounds (2–6 & 9–15). Their chemical structures were determined on the basis of extensive spectroscopic analysis using 1D, 2D NMR, and mass spectrometric analysis. Among the known compounds, 4–6, 9 and 12 were isolated for ...
- DOI:
- 10.1080/14786419.2018.1443099
- https://doi.org/10.1080/14786419.2018.1443099
- Author:
- C. Emir; A. Emir; B. Bozkurt; N.U. Somer
- Source:
- South African journal of botany 2019 v.121 pp. 63-67
- ISSN:
- 0254-6299
- Subject:
- Galanthus; acetylcholinesterase; chemical constituents of plants; chemical structure; cholinesterase; enzyme activity; enzyme inhibition; hordenine; lignans; metabolites; niacin; terpenoids; Turkey (country)
- Abstract:
- ... Phytochemical studies on Galanthus alpinus Sosn. var. alpinus from Turkey resulted in the isolation of 11 metabolites including, 1 terpenoid; (+)-blumenol A 1, 2 lignans; pinoresinol 2 and epipinoresinol 3, and 8 other compounds; (+)-homolycorine 4, (+)-8-O-demethylhomolycorine 5, arolycoricidine 6, N-Trans-feruloyltyramine 7, (−)-lycorine 8, nicotinic acid 9, O-methylnorbelladine 10 and hordenine ...
- DOI:
- 10.1016/j.sajb.2018.10.021
- https://doi.org/10.1016/j.sajb.2018.10.021
- Author:
- James M. Wood; Eufrânio N. da Silva Júnior; John F. Bower
- Source:
- Organic letters 2019 v.22 no.1 pp. 265-269
- ISSN:
- 1523-7052
- Subject:
- benzoquinones; catalytic activity; chemical structure; cycloaddition reactions; lignans; naphthoquinones; polyketides; rhodium
- Abstract:
- ... The first examples of Rh-catalyzed [2 + 2 + 2] cycloadditions between diynes and benzoquinones are described. The method enables de novo and step-economical access to challenging naphthoquinones that are of relevance to lignan and type II polyketide synthesis. The value of the chemistry is demonstrated by a short total synthesis of justicidone. ...
- DOI:
- 10.1021/acs.orglett.9b04266
- https://doi.org/10.1021/acs.orglett.9b04266
- Author:
- Yi Zhou; Mei Jin; Chunshi Jin; Chao Ye; Jiaming Wang; Jinfeng Sun; Cheng-Xi Wei; Wei Zhou; Gao Li
- Source:
- Natural product research 2020 v.34 no.2 pp. 225-232
- ISSN:
- 1478-6427
- Subject:
- Amaranthaceae; anti-inflammatory activity; caffeic acid; chemical structure; ethanol; interleukin-6; lignans; metabolites; nitric oxide; nuclear magnetic resonance spectroscopy; tumor necrosis factor-alpha
- Abstract:
- ... One new aryldihydronaphthalene-type lignan (1) together with eight known lignans (2-4, 7–11) as well as two caffeic-acid dimers (5, 6) were isolated from an ethanol extract of the whole plant of Corispermum mongolicum Iljin (Chenopodiaceae). The chemical structures of these compounds were determined from 1D and 2D NMR and HR-ESI-MS spectra, and results were compared with data from the literature. ...
- DOI:
- 10.1080/14786419.2018.1527835
- https://doi.org/10.1080/14786419.2018.1527835
- Author:
- Xin-Ya XU; Dong-Ying WANG; Chuen-Fai KU; Yang ZHAO; Han CHENG; Kang-Lun LIU; Li-Jun RONG; Hong-Jie ZHANG
- Source:
- Chinese journal of natural medicines 2019 v.17 no.12 pp. 945-952
- ISSN:
- 1875-5364
- Subject:
- Human immunodeficiency virus 1; Justicia procumbens; Oriental traditional medicine; acetates; antiretroviral properties; chemical structure; cytotoxicity; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
- Abstract:
- ... Twenty-one lignans including three new ones (1, 2 and 13) were isolated from Justicia procumbens. The chemical structures of the new lignans were determined by spectroscopic means including 1D and 2D NMR analysis. These compounds were evaluated for their cytotoxic and anti-HIV activities. The new secoisolariciresinol dimethyl ether acetate (13) exhibited anti-HIV-1 activity with an IC50 value of 5 ...
- DOI:
- 10.1016/S1875-5364(19)30117-7
- https://doi.org/10.1016/S1875-5364(19)30117-7
- Author:
- Daniel E. Jeffries; Craig W. Lindsley
- Source:
- Journal of organic chemistry 2019 v.84 no.9 pp. 5974-5979
- ISSN:
- 1520-6904
- Subject:
- chemical structure; chromatography; derivatization; lignans; organic chemistry; stereoselective synthesis
- Abstract:
- ... Lignans are a structurally diverse class of natural products with extensive pharmacological effects. Here we report the syntheses of both natural and unnatural dibenzylbutane lignans from a common intermediate, which is prepared in five steps from known materials. Derivatization of this intermediate affords lignans featuring contiguous stereocenters in a high diastereomeric purity after chromatogr ...
- DOI:
- 10.1021/acs.joc.9b00633
- https://doi.org/10.1021/acs.joc.9b00633
- Author:
- Xiang Dong Su; Wei Li; Jin Yeul Ma; Young Ho Kim
- Source:
- Natural product research 2018 v.32 no.19 pp. 2347-2351
- ISSN:
- 1478-6427
- Subject:
- Epimedium koreanum; aerial parts; chemical composition; chemical structure; chemotaxonomy; flavonoids; lignans; mass spectrometry; nuclear magnetic resonance spectroscopy; phenols
- Abstract:
- ... In this study, 21 compounds were isolated from the aerial parts of Epimedium koreanum Nakai, including 6 phenols (1–5 and 10), 4 lignans (6–9) and 11 flavonoids (11–21). The chemical structures of those isolates were established after extensive one-and two-dimensional nuclear magnetic resonance and mass spectroscopy analyses. This is the first report of compounds 2, 3, 4 and 9 in E. koreanum and o ...
- DOI:
- 10.1080/14786419.2017.1405412
- https://doi.org/10.1080/14786419.2017.1405412
- Author:
- Tianshan Wang; Xiaopeng Wu; Yanping Liu; Youping Luo; Xiang Li; Yujie Zhou; AiPing Yang; Zhengmeng Yan; Ling Ye; Siwei Chen; Jinshuai Fu; Xianzhi Jiao
- Source:
- Revista Brasileira de Farmacognosia 2018 v.28 no.2 pp. 235-238
- ISSN:
- 0102-695X
- Subject:
- Polyalthia; alkaloids; antineoplastic activity; branches; chemical composition; chemical structure; cytotoxicity; ethanol; gossypol; human cell lines; humans; inhibitory concentration 50; lignans; neoplasm cells; spectroscopy
- Abstract:
- ... Twelve known compounds, including eight alkaloids, three lignans and one gossypol derivative, were isolated from the branches of Polyalthia rumphii (Blume ex Hensch.) Merr., Annonaceae. The chemical structures were determined by spectroscopic methods and comparison with literature data. All the isolates were evaluated the cytotoxicity against three human cancer cell lines: Hela, MCF-7 and A549, th ...
- DOI:
- 10.1016/j.bjp.2018.03.004
- https://doi.org/10.1016/j.bjp.2018.03.004
- Author:
- Xiaojuan Wang; Jiabao Liu; Pankaj Pandey; Frank R. Fronczek; Robert J. Doerksen; Jiabao Chen; Xinzhu Qi; Peicheng Zhang; Daneel Ferreira; Frederick A. Valeriote; Hua Sun; Shuai Li; Mark T. Hamann
- Source:
- Organic letters 2018 v.20 no.18 pp. 5559-5563
- ISSN:
- 1523-7052
- Subject:
- Kadsura; X-ray diffraction; acetaminophen; carbon; chemical reactions; chemical structure; chemoprevention; circular dichroism spectroscopy; crystallography; cytotoxicity; hepatoprotective effect; lignans; nuclear magnetic resonance spectroscopy; roots
- Abstract:
- ... Kadsuraols A–C (1–3), which are tetrahydrocyclobutaphenanthrofuranone-type lignans with a new carbon skeleton comprising a four-membered ring across C-1′–C-8, have been isolated from the roots of Kadsura longipedunculata. Their structures and absolute configurations were unambiguously determined using nuclear magnetic resonance, X-ray diffraction crystallography, DP4+ calculations, and computed an ...
- DOI:
- 10.1021/acs.orglett.8b02207
- https://doi.org/10.1021/acs.orglett.8b02207
- Author:
- Shu-jun Shan; Jun Luo; De-ran Xu; Xing-liang Niu; Ding-qiao Xu; Pan-pan Zhang; Ling-yi Kong
- Source:
- Industrial crops and products 2018 v.112 pp. 830-838
- ISSN:
- 0926-6690
- Subject:
- Ginkgo biloba; antioxidant activity; antioxidants; bioactive compounds; butanol; chemical structure; flavonoids; functional foods; glycosides; inhibitory concentration 50; leaves; lignans; medicinal plants; medicine; nuclear magnetic resonance spectroscopy; phenylpropanoids; research and development; seeds; tandem mass spectrometry
- Abstract:
- ... Ginkgo biloba L. is a widely used medicinal plant that has a high concentration of its bioactive components, flavonoids and ginkgolides, in its leaves. Gingko seeds are also consumed as a functional food and medicine throughout the world to slow the ageing process. However, there have been few phytochemical studies of the phenylpropanoids from Ginkgo seeds. To elucidate the active components, we s ...
- DOI:
- 10.1016/j.indcrop.2017.12.013
- https://doi.org/10.1016/j.indcrop.2017.12.013
- Author:
- Hyoung-Geun Kim; Hyun-Ji Oh; Jung-Hwan Ko; Sun-Woo Joo; Yeong-Geun Lee; Yun-Su Baek; Dae Young Lee; Nam-In Baek
- Source:
- Chemistry of natural compounds 2019 v.55 no.4 pp. 610-613
- ISSN:
- 0009-3130
- Subject:
- Chrysanthemum morifolium; chemical structure; cultivars; glucosides; lignans; nuclear magnetic resonance spectroscopy; silica gel; spectral analysis; stems
- Abstract:
- ... A new neolignan glucoside has been isolated from Chrysanthemum morifolium ‘Baekma’ cultivar through repeated silica gel and octadecyl silica gel (ODS) column chromatographies. On the basis of spectroscopic data including NMR, MS, and IR, the chemical structure of the new neolignan glucoside was determined to be (7S,8S)-7-O-[1′-(4′,5′-dihydroxy-3′-methoxyphenyl)propanol]guaiacylglycerol 4-O-β-D-glu ...
- DOI:
- 10.1007/s10600-019-02760-1
- https://doi.org/10.1007/s10600-019-02760-1
- Author:
- Bing-You Yang; Zhang-Lin Chen; Yan Liu; Jiang-Tao Guo; Hai-Xue Kuang
- Source:
- Natural product research 2019 v.33 no.3 pp. 340-346
- ISSN:
- 1478-6427
- Subject:
- Calamus; Schisandra chinensis; chemical structure; cisplatin; cytotoxicity; human cell lines; inhibitory concentration 50; lignans; mass spectrometry; neoplasm cells; nuclear magnetic resonance spectroscopy; stems
- Abstract:
- ... A new lignan named schilignan F (1), together with twelve known ones (2–13), were isolated from the rattan stems of Schisandra chinensis. Their chemical structures were elucidated by spectroscopic methods including one and two-dimensional NMR spectra referring to the literatures as well as high-resolution mass spectrometric analysis. All compounds were evaluated for their cytotoxicities against hu ...
- DOI:
- 10.1080/14786419.2018.1452000
- https://doi.org/10.1080/14786419.2018.1452000
- Author:
- Yan Zhao; Wei Zhou; Shengbao Diao; Zhe Jiang; Mei Jin; Gao Li
- Source:
- Biochemical systematics and ecology 2019 v.87 pp. 103957
- ISSN:
- 0305-1978
- Subject:
- Juglans mandshurica; anthraquinones; chemical structure; chemotaxonomy; flavonoids; glycosides; lignans; naphthoquinones; nuclear magnetic resonance spectroscopy; phenols; roots; secoiridoids; secondary metabolites; triterpenoids
- Abstract:
- ... Phytochemical research of the roots of Juglans mandshurica Maxim. (Juglandaceae) verified 37 secondary metabolites, including thirteen diarylheptanoids (1–13), five naphthoquinones (14–18), five tetralones (19–23), three lignans (24–26), three phenols (27–29), two anthraquinones (30–31), two triterpenoids (32–33), two secoiridoids (34–35), one naphthalenyl glycoside (36), and one flavonoid (37). T ...
- DOI:
- 10.1016/j.bse.2019.103957
- https://doi.org/10.1016/j.bse.2019.103957
- Author:
- Ehu Camille Aka; Eric Wimmer; Elvina Barré; Natarajan Vasudevan; Daniel Cortés-Borda; Tchirioua Ekou; Lynda Ekou; Mireia Rodriguez-Zubiri; François-Xavier Felpin
- Source:
- Journal of organic chemistry 2019 v.84 no.21 pp. 14101-14112
- ISSN:
- 1520-6904
- Subject:
- algorithms; automation; catalysts; catalytic activity; chemical structure; closed loop systems; cobalt; dimerization; instrumentation; lignans; monitoring; oxidants; phenols; process control; screening; temperature
- Abstract:
- ... Naturally occurring benzoxanthenones, which belong to the vast family of lignans, are promising biologically relevant targets. They are biosynthetically produced by the oxidative dimerization of 2-propenyl phenols. In this manuscript, we disclose a powerful automated flow-based strategy for identifying and optimizing a cobalt-catalyzed oxidizing system for the bioinspired dimerization of 2-propeny ...
- DOI:
- 10.1021/acs.joc.9b02263
- https://doi.org/10.1021/acs.joc.9b02263
- Author:
- Yeong-Geun Lee; Isabel Rodriguez; Youn Hee Nam; Jung Eun Gwag; Sang Ho Woo; Hyoung-Geun Kim; Jung-Hwan Ko; Bin Na Hong; Tong Ho Kang; Nam-In Baek
- Source:
- Applied biological chemistry 2019 v.62 no.1 pp. 7
- ISSN:
- 2468-0842
- Subject:
- Danio rerio; Forsythia viridissima var. koreana; Microbacterium esteraromaticum; alloxan; butanol; chemical structure; flowers; glycosides; hypoglycemic agents; islets of Langerhans; lactones; lignans; methanol
- Abstract:
- ... Repeated column separation yielded four enterolactone type lignans from Forsythia koreana flowers (FKF), whose chemical structures were identified using several spectral technics. FKF MeOH extract (FKFM) and four lignans significantly recovered aloxan induced pancreatic islet in zebrafish. Especially, aglycones, 1 and 3, exhibited relatively higher activity than the lignan glycosides, 2 and 4. The ...
- DOI:
- 10.1186/s13765-019-0411-y
- https://doi.org/10.1186/s13765-019-0411-y
- Author:
- Diana I. Saavedra; Benjamin D. Rencher; Doo-Hyun Kwon; Stacey J. Smith; Daniel H. Ess; Merritt B. Andrus
- Source:
- Journal of organic chemistry 2018 v.83 no.4 pp. 2018-2026
- ISSN:
- 1520-6904
- Subject:
- antineoplastic activity; antineoplastic agents; chemical structure; cycloaddition reactions; density functional theory; hydrogen; lignans; organic chemistry; secondary metabolites
- Abstract:
- ... Deoxypodophyllotoxin is a secondary metabolite lignan possessing potent anticancer activity with potential as a precursor for known anticancer drugs, but its use is limited by scarcity from natural sources. We here report the total synthesis of racemic deoxypodophyllotoxin in seven steps using an intramolecular styryl Diels–Alder reaction strategy uniquely suited to assemble the deoxypodophyllotox ...
- DOI:
- 10.1021/acs.joc.7b02957
- https://doi.org/10.1021/acs.joc.7b02957
- Author:
- Peter Hartmann; Mattia Lazzarotto; Lorenz Steiner; Emmanuel Cigan; Silvan Poschenrieder; Peter Sagmeister; Michael Fuchs
- Source:
- Journal of organic chemistry 2019 v.84 no.9 pp. 5831-5837
- ISSN:
- 1520-6904
- Subject:
- aldehydes; allylation; chemical structure; hydrogen; lignans; organic chemistry; organobromine compounds; phosphates; stereoselective synthesis
- Abstract:
- ... The asymmetric allylation under the assistance of catalytic amounts of 3,3′-bis(2,4,6-triisopropylphenyl)-1,1′-binaphthyl-2,2′-diyl hydrogen phosphate (TRIP) allows the concise construction of the lignan scaffold from simple aldehydes and allylic bromides with full control of the two formed stereocenters. This young methodology has been employed to synthesize four naturally and pharmaceutically ac ...
- DOI:
- 10.1021/acs.joc.9b00065
- https://doi.org/10.1021/acs.joc.9b00065
- Author:
- Ruth Anyango Omole; Mainen Julius Moshi; Matthias Heydenreich; Hamisi Masanja Malebo; Jeremiah Waweru Gathirwa; Sharon Alice Ochieng’; Leonida Kerubo Omosa; Jacob Ogweno Midiwo
- Source:
- Phytochemistry letters 2019 v.30 pp. 194-200
- ISSN:
- 1874-3900
- Subject:
- Hypoestes; Plasmodium falciparum; antiplasmodial properties; chemical structure; diterpenoids; inhibitory concentration 50; lignans; parasites; screening; ultraviolet-visible spectroscopy
- Abstract:
- ... Bioassay-guided screening of Hypoestes verticillaris whole plant CH2Cl2:MeOH (1:1) extract for anti-plasmodial activity yielded four new compounds: two lignans 2, 6-dimethoxysavinin (1), 2,6-dimethoxy-(7E)-7,8-dehydroheliobuphthalmin (2); and two fusicoccane diterpenoids: 11(12)-epoxyhypoestenone (3) and 3(11)-epoxyhypoestenone (4). The chemical structures were determined using various spectroscop ...
- DOI:
- 10.1016/j.phytol.2019.02.019
- https://doi.org/10.1016/j.phytol.2019.02.019
- Author:
- Bo Liu; Shou-Zhen Du; Fang Kuang; Ying Liu; Xing-Jun Tian; Ye-Gao Chen; Rui Zhan
- Source:
- Natural product research 2019 v.33 no.1 pp. 95-100
- ISSN:
- 1478-6427
- Subject:
- branches; chemical structure; cytotoxicity; humans; leaves; lignans; neoplasms; spectral analysis
- Abstract:
- ... Two new dibenzylbutyrolactol lignans and three known dibenzylbutyrolactone lignans were isolated from the twigs and leaves of Horsfieldia kingii. Their structures were elucidated by spectroscopic analysis. Cytotoxicity evaluation of these compounds against five human tumour lines showed no inhibitory effects. ...
- DOI:
- 10.1080/14786419.2018.1437429
- https://doi.org/10.1080/14786419.2018.1437429
- Author:
- Yang Zhang; Bowen Deng; Yida Cui; Xue Chen; Jiayi Bi; Guogang Zhang
- Source:
- Natural medicines 2018 v.72 no.4 pp. 946-953
- ISSN:
- 1340-3443
- Subject:
- Ilex pubescens; chemical structure; glucosides; lignans; nuclear magnetic resonance spectroscopy; roots
- Abstract:
- ... Two new secoiridoid glucosides, ilexpublignoside (1), pubzenoside (2), and a new lignan, ilexlignan B (3), along with seven known compounds (4–10) were isolated from the roots of Ilex pubescens for the first time. Their chemical structures were elucidated on the basis of extensive spectroscopic methods, including IR, UV, HR-ESI–MS, CD, NMR experiments, as well as comparison with the reported data. ...
- DOI:
- 10.1007/s11418-018-1227-5
- https://doi.org/10.1007/s11418-018-1227-5
34. The total synthesis of sevanol, a novel lignan isolated from the thyme plant (Thymus armeniacus)
- Author:
- O.A. Belozerova; V.I. Deigin; A.Yu. Khrushchev; M.A. Dubinnyi; V.S. Kublitski
- Source:
- Tetrahedron 2018 v.74 pp. 1449-1453
- ISSN:
- 0040-4020
- Subject:
- bioactive properties; chemical structure; dimerization; ferric chloride; lignans; thyme
- Abstract:
- ... Recently, a novel lignan sevanol was isolated from the thyme plant Thymus armeniacus. During structure-functional elucidation it showed significant biological activity on ASIC3 acid sensing channels. Herein we describe the first synthesis of sevanol with a 3% overall yield. The construction of a dihydronaphthalene ring by oxidative dimerization of a protected dihydroxycinnamic acid ester in the pr ...
- DOI:
- 10.1016/j.tet.2018.02.005
- https://doi.org/10.1016/j.tet.2018.02.005
- Author:
- Wei Zhou; Jinjun Shan; Minxin Meng
- Source:
- Journal of chromatography 2018 v.1563 pp. 99-123
- ISSN:
- 0021-9673
- Subject:
- bioactive compounds; blood; caffeic acid; chemical structure; chlorogenic acid; chromatography; fever; herbal medicines; human serum albumin; inflammation; kaempferol; lignans; liquids; mass spectrometry; metabolites; molecular models; monoterpenoids; oleanolic acid; prototypes; quercetin; rats; reference standards; saponins; screening
- Abstract:
- ... Fructus Gardeniae-Fructus Forsythiae herb pair is an herbal formula used extensively to treat inflammation and fever, but few systematic identification studies of the bioactive components have been reported. Herein, the unknown analogues in the first-step screening were rapidly identified from representative compounds in different structure types (geniposide as iridoid type, crocetin as crocetin t ...
- DOI:
- 10.1016/j.chroma.2018.05.067
- https://doi.org/10.1016/j.chroma.2018.05.067
- Author:
- Gustav Komlaga; Grégory Genta-Jouve; Sandrine Cojean; Rita A. Dickson; Merlin L.K. Mensah; Philippe M. Loiseau; Pierre Champy; Mehdi A. Beniddir
- Source:
- Tetrahedron letters 2017 pp. -
- ISSN:
- 0040-4039
- Subject:
- Phyllanthus fraternus; Plasmodium falciparum; Securinega; alkaloids; antimalarials; antiparasitic properties; chemical reactions; chemical structure; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
- Abstract:
- ... The chemical investigation of the antimalarial plant Phyllanthus fraternus G. L. Webster (Phyllanthaceae) resulted in the discovery of the Securinega alkaloid (+)-allonorsecurinine (1), previously reported as a synthetic compound, together with the known ent-norsecurinine (2), nirurine (3), bubbialine (4), epibubbialine (5) and the lignan phyllanthin (6). The structure and absolute configuration o ...
- DOI:
- 10.1016/j.tetlet.2017.08.045
- https://doi.org/10.1016/j.tetlet.2017.08.045
- Author:
- Manat Pohmakotr; Chutima Kuhakarn; Vichai Reutrakul; Darunee Soorukram
- Source:
- Tetrahedron letters 2017 pp. -
- ISSN:
- 0040-4039
- Subject:
- bioactive properties; chemical reactions; chemical structure; lignans; stereochemistry; stereoselectivity
- Abstract:
- ... Furofurans are one of the largest sub-types of classical lignans which have been found to possess a broad range of important biological activities. Tremendous efforts have been directed to develop synthetic methodologies for the synthesis of furofurans, especially in a stereoselective manner, due to their interesting bioactivities associated with the structural and stereochemical complexity. This ...
- DOI:
- 10.1016/j.tetlet.2017.11.011
- https://doi.org/10.1016/j.tetlet.2017.11.011
- Author:
- Darunee Soorukram; Manat Pohmakotr; Chutima Kuhakarn; Vichai Reutrakul
- Source:
- Journal of organic chemistry 2018 v.83 no.7 pp. 4173-4179
- ISSN:
- 1520-6904
- Subject:
- biochemical pathways; chemical reactions; chemical structure; lignans; organic chemistry; stereoselectivity
- Abstract:
- ... A bioinspired asymmetric total synthesis of a structurally unique subtype of lignan, namely, (−)-gymnothelignan V, was achieved. The key synthetic sequences involved reduction of the eupomatilone skeleton leading to (−)-gymnothelignan J followed by the formation of the corresponding oxocarbenium ion and stereoselective intramolecular Friedel–Crafts reaction. Our synthetic approach provides the inf ...
- DOI:
- 10.1021/acs.joc.8b00164
- https://doi.org/10.1021/acs.joc.8b00164
- Author:
- Zhao Jin-Xin; Fan Yao-Yue; Xu Jin-Biao; Gan Li-She; Xu Cheng-Hui; Ding Jian; Yue Jian-Min
- Source:
- Journal of natural products 2017 v.80 no.2 pp. 356-362
- ISSN:
- 1520-6025
- Subject:
- Cephalotaxus; X-ray diffraction; anticarcinogenic activity; biosynthesis; branches; chemical structure; cytotoxicity; diterpenoids; inhibitory concentration 50; leaves; lignans
- Abstract:
- ... Five new diterpenoids including two Cephalotaxus troponoids (1 and 2), two 17-nor-cephalotane-type diterpenoids (3 and 4), and an abietane-type diterpenoid (5), two new lignans (6 and 7), and a new trisnorneoligan (8) along with eight known compounds were identified from the twigs and leaves of Cephalotaxus fortunei. The structure of 11-hydroxyhainanolidol was revised as 10-hydroxyhainanolidol (9) ...
- DOI:
- 10.1021/acs.jnatprod.6b00802
- https://doi.org/10.1021/acs.jnatprod.6b00802
- Author:
- Le Zhou; Li-Li Lou; Wei Wang; Bin Lin; Jun-Ning Chen; Xiao-Bo Wang; Xiao-Xiao Huang; Shao-Jiang Song
- Source:
- Journal of functional foods 2017 v.37 pp. 322-329
- ISSN:
- 1756-4646
- Subject:
- Alzheimer disease; Rubus idaeus; chemical composition; chemical structure; functional foods; lignans; neuroprotective effect; spectral analysis; stereochemistry
- Abstract:
- ... Red raspberry (Rubus idaeus L.) is an edible fruit-producing species belonging to the Rosaceae family. In our search for potential agents for treating Alzheimer’s disease in this functional food, we decided to investigate the chemical constituents of red raspberry. Four pairs of enantiomeric 8-O-4′-type neolignans (1a/1b–4a/4b), including three new compounds (1a/1b and 2a), were identified from th ...
- DOI:
- 10.1016/j.jff.2017.08.007
- https://doi.org/10.1016/j.jff.2017.08.007
- Author:
- Jiabao Liu; Pankaj Pandey; Xiaojuan Wang; Xinzhu Qi; Jiabao Chen; Hua Sun; Peicheng Zhang; Yuanqing Ding; Daneel Ferreira; Robert J. Doerksen; Mark T. Hamann; Shuai Li
- Source:
- Journal of natural products 2018 v.81 no.4 pp. 846-857
- ISSN:
- 1520-6025
- Subject:
- Kadsura; cell viability; chemical structure; circular dichroism spectroscopy; hepatoprotective effect; human cell lines; lignans; mass spectrometry; nuclear magnetic resonance spectroscopy; roots; survival rate; toxicity
- Abstract:
- ... Five new dibenzocyclooctadiene lignans, longipedlignans A–E (1–5), five new tetrahydrobenzocyclooctabenzofuranones (6–10), and 18 known analogues (11–28) were isolated from the roots of Kadsura longipedunculata. Compounds 6–10 are new spirobenzofuranoid–dibenzocyclooctadiene-type lignans. Their structures and absolute configurations were established using a combination of MS, NMR, and electronic c ...
- DOI:
- 10.1021/acs.jnatprod.7b00934
- https://doi.org/10.1021/acs.jnatprod.7b00934
- Author:
- Takahiro Matsumoto; Seikou Nakamura; Souichi Nakashima; Tomoe Ohta; Keiko Ogawa; Masashi Fukaya; Junko Tsukioka; Tomohiro Hasei; Tetsushi Watanabe; Hisashi Matsuda
- Source:
- Phytochemistry 2017 v.137 pp. 101-108
- ISSN:
- 0031-9422
- Subject:
- aerial parts; chemical structure; cytotoxicity; glucosides; lignans; nuclear magnetic resonance spectroscopy; protective effect; spectral analysis; Japan
- Abstract:
- ... Six neolignan glucosides, named isodonosides I–VI, and a megastigmane glucoside named isodonmegastigmane I, were isolated together with 15 known compounds from the methanolic extract of aerial parts of Isodon japonicus cultivated in Tokushima, Japan. The chemical structures of the compounds were elucidated based on their MS and NMR spectroscopic analysis. The absolute configurations of the neolign ...
- DOI:
- 10.1016/j.phytochem.2017.02.007
- https://doi.org/10.1016/j.phytochem.2017.02.007
- Author:
- Seoung Rak Lee; Eunjung Moon; Ki Hyun Kim
- Source:
- Phytochemistry letters 2017 v.20 pp. 98-101
- ISSN:
- 1874-3900
- Subject:
- Ipomoea nil; anti-inflammatory activity; chemical structure; cytotoxicity; ethanol; glycosides; inhibitory concentration 50; lignans; lipopolysaccharides; mice; monoterpenoids; nitric oxide; nuclear magnetic resonance spectroscopy; seeds; spectral analysis
- Abstract:
- ... Phytochemical investigation of an EtOH extract of Pharbitis nil seeds (Convolvulaceae) resulted in the isolation and identification of a new neolignan, 7R,8S-threo-dihydroxydehydrodiconiferyl alcohol (1), and a new monoterpene glycoside, (3Z,7S)-7-hydroxy-3,7-dimethyl-3,8-octadienyl-β-d-glucopyranoside (2), together with a known compound, ethyl α-l-arabinofuranoside (3). The chemical structures of ...
- DOI:
- 10.1016/j.phytol.2017.04.019
- https://doi.org/10.1016/j.phytol.2017.04.019
- Author:
- Liu Ye; Yu Heng-Yi; Wang Yan-Mei; Tian Tian; Wu Wen-Ming; Zhou Ming; Meng Xiang-Gao; Ruan Han-Li
- Source:
- Journal of natural products 2017 v.80 no.4 pp. 1117-1124
- ISSN:
- 1520-6025
- Subject:
- Schisandra; X-ray diffraction; chemical structure; fruits; hydrogen peroxide; irradiation; lignans; models; neuroprotective effect; spectral analysis
- Abstract:
- ... Nine new lignans (1–9) and ten known analogues (10–19) were isolated from the fruits of Schisandra bicolor var. tuberculata. The structures of compounds 1–9 were established on the basis of spectroscopic data analysis. The absolute configuration of compound 1 was determined by single-crystal X-ray diffraction analysis with Cu Kα irradiation techniques, and the absolute configurations of compounds ...
- DOI:
- 10.1021/acs.jnatprod.7b00035
- https://doi.org/10.1021/acs.jnatprod.7b00035
- Author:
- Jia Chen; Chun-Chao Zhao; Jian-Hua Shao; Ju-Di Fan; Xu-Hua Huang
- Source:
- Chemistry of natural compounds 2017 v.53 no.4 pp. 626-628
- ISSN:
- 0009-3130
- Subject:
- Galium verum; Helicoverpa armigera; Scorpiones; chemical structure; glucosides; insecticidal properties; lignans; mortality; poisoning; scorpion venoms; spectral analysis; stomach; toxicity
- Abstract:
- ... A new lignan glucoside, galiveroside A (1), and seven known compounds (2–8), were isolated from Galium verum L. The structure of 1 was elucidated on the basis of extensive spectroscopic analyses. Compound 1, at the concentration of 5 mg/mL, showed insecticide activity to 3 age cotton bollworm with a mortality of 16.3% through stomach poisoning. When combined with a recombinant scorpion toxin rLqh ...
- DOI:
- 10.1007/s10600-017-2075-3
- https://doi.org/10.1007/s10600-017-2075-3
- Author:
- Jian-Hua Shao; Xue-Wei Zhang; Zi-Ling Dong; Si-Hui Li; Ben-Jie Miao; Ke-Zhi Cheng
- Source:
- Chemistry of natural compounds 2017 v.53 no.6 pp. 1025-1027
- ISSN:
- 0009-3130
- Subject:
- Cyclea; chemical structure; glucosides; lignans; spectral analysis
- Abstract:
- ... A new lignan glucoside 1, along with two known lignans (2, 3), was isolated from Cyclea racemosa Oliv. Its structure was elucidated as (+)-7′-methoxylariciresinol 4-O-β-D-glucopyranoside on the basis of extensive spectroscopic analyses. ...
- DOI:
- 10.1007/s10600-017-2193-y
- https://doi.org/10.1007/s10600-017-2193-y
- Author:
- Lorenzo Cecchi; Marzia Innocenti; Fabrizio Melani; Marzia Migliorini; Lanfranco Conte; Nadia Mulinacci
- Source:
- Food chemistry 2017 v.219 pp. 148-157
- ISSN:
- 0308-8146
- Subject:
- bleaching; chemical structure; chromatography; deodorization; extra-virgin olive oil; lignans; oil refining; Italy; Spain; Tunisia
- Abstract:
- ... Herein we describe the influence of olive oil refining processes on the lignan profile. The detection of new isobaric lignans is suggested to reveal frauds in commercial extra-Virgin Olive Oils. We analyzed five commercial olive oils by HPLC-DAD-TOF/MS to evaluate their lignan content and detected, for the first time, some isobaric forms of natural (+)-pinoresinol and (+)-1-acetoxypinoresinol. The ...
- DOI:
- 10.1016/j.foodchem.2016.09.132
- https://doi.org/10.1016/j.foodchem.2016.09.132
- Author:
- Bing-You Yang; Yu-Meng Luo; Yan Liu; Xin Yin; Yuan-Yuan Zhou; Hai-Xue Kuang
- Source:
- Phytochemistry letters 2018 v.28 pp. 8-12
- ISSN:
- 1874-3900
- Subject:
- Datura metel; chemical structure; cytotoxicity; lignans; mass spectrometry; nuclear magnetic resonance spectroscopy; roots
- Abstract:
- ... Two new lignans (1-2) and a new natural product (3), as well as eighteen known compounds (4-21), were isolated from the roots of Datura metel L. Compounds 8, 11, 12, 14, 16, 17, 19 and 21 were isolated from Datura metel L for the first time. These compounds’ chemical structures were elucidated by spectroscopic methods, including 1D and 2D NMR spectra with references to the literature, as well as h ...
- DOI:
- 10.1016/j.phytol.2018.08.002
- https://doi.org/10.1016/j.phytol.2018.08.002
- Author:
- Yunzhi Li; Hui Cheng; Ren Yue; Mengmeng Duan; Mingdong Liu
- Source:
- Natural product research 2017 v.31 no.9 pp. 1047-1051
- ISSN:
- 1478-6427
- Subject:
- Aralia; chemical structure; ionization; lignans; nuclear magnetic resonance spectroscopy; saponins
- Abstract:
- ... A phytochemical investigation was carried out to the root of Aralia echinocauis , and a new neolignan glycoside, 3-{3,5-dimethoxy-4β- d -Glucopyranoside-2-[3-(3-β- d -Glucopyranoside-4-methoxy-phenyl)-allyl]-phenyl}-prop-2-en-1-ol (1), together with a known saponin, araliasaponin II (2) for the first time was obtained . The chemical structure of compound 1 was identified mainly by the analysis of ...
- DOI:
- 10.1080/14786419.2016.1269095
- https://doi.org/10.1080/14786419.2016.1269095
- Author:
- Sonda Ammar; Maria del Mar Contreras; Boutheina Gargouri; Antonio Segura‐Carretero; Mohamed Bouaziz
- Source:
- Phytochemical analysis 2017 v.28 no.3 pp. 217-229
- ISSN:
- 0958-0344
- Subject:
- Olea europaea; aldehydes; bioactive compounds; bioactive properties; byproducts; chemical structure; coumarins; cultivars; flavonoids; high performance liquid chromatography; leaves; lignans; mass spectrometry; metabolites; metabolomics; olives; phenolic acids; phytopharmaceuticals; roots; secoiridoids; stems; sugars; trees; wood
- Abstract:
- ... INTRODUCTION: Olea europaea L. organs such as leaves, stems and roots have been associated with numerous in vivo and in vitro biological activities and used for traditional medicinal purposes. However, tree wood is an untapped resource with little information about their chemical composition. OBJECTIVE: That is why, the objective of this study is to increase the knowledge about phytochemicals from ...
- DOI:
- 10.1002/pca.2664
- https://doi.org/10.1002/pca.2664
51. Asymmetric glycolate alkylation approach towards total synthesis of 8-O.6′ and 8-O.4′-neolignans
- Author:
- Mukesh Gangar; Mangilal Chouhan; Sandeep Goyal; M. Harikrishnan; R Chandran; Avinash Ittuveetil; Vipin A. Nair
- Source:
- Tetrahedron letters 2016 v.57 no.52 pp. 5931-5934
- ISSN:
- 0040-4039
- Subject:
- alkylation; chemical structure; lignans; stereoselectivity
- Abstract:
- ... The glycolate alkylation approach for the total synthesis of 8-O.6′ and 8-O.4′-neolignans has been optimized affording the natural products with high overall yields and excellent stereoselectivity. The developed approach can be further utilized towards the synthesis of many natural and unnatural neolignans. This is the first approach for the synthesis of neolignans using asymmetric glycolate alkyl ...
- DOI:
- 10.1016/j.tetlet.2016.11.087
- https://doi.org/10.1016/j.tetlet.2016.11.087
- Author:
- Zhong-Lin Sun; Jian-Ming He; Shuang-Ying Wang; Ru Ma; Proma Khondkar; Glenn W. Kaatz; Simon Gibbons; Qing Mu
- Source:
- RSC advances 2016 v.6 no.49 pp. 43518-43525
- ISSN:
- 2046-2069
- Subject:
- Oriental traditional medicine; Piper betle; active ingredients; antibiotic resistance; bacteria; bioassays; chemical structure; circular dichroism spectroscopy; cytotoxicity; gel chromatography; growth models; herbs; lignans; methicillin; methicillin-resistant Staphylococcus aureus; norfloxacin; nuclear magnetic resonance spectroscopy; silica gel; synergism; therapeutics; transporters
- Abstract:
- ... This research seeks to address the problem of methicillin-resistant Staphylococcus aureus (MRSA) by discovering synergistic antibacterial natural substances from traditional Chinese herbs using antibacterial bioassays. Six compounds, including three neolignans (−)-acuminatin (1), (−)-denudatin B (2), puberulin D (3), and three benzocyclohexane oxide derivatives ferrudiol (4), ellipeiopsol B (5) an ...
- DOI:
- 10.1039/c6ra10199b
- https://doi.org/10.1039/c6ra10199b
53. Coixlachryside A: A new lignan glycoside from the roots of Coix lachryma-jobi L. var. ma-yuen Stapf.
- Author:
- Seong Su Hong; Chun Whan Choi; Yun-Hyeok Choi; Joa Sub Oh
- Source:
- Phytochemistry letters 2016 v.17 pp. 152-157
- ISSN:
- 1874-3900
- Subject:
- Coix lacryma-jobi; chemical structure; chromatography; circular dichroism spectroscopy; glycosides; lignans; nuclear magnetic resonance spectroscopy; roots; spectral analysis
- Abstract:
- ... A new lignan glycoside, 1-[3,6-(4,4⿲-dihydroxy-3,3⿲-dimethoxy-δ-truxinyl)-β-fructofuranosyl]-α-glucopyranoside (1), named coixlachryside A, together with nine known simple phenolic compounds (3⿿11) were isolated from the roots of Coix lachryma-jobi var. ma-yuen using various chromatographic methods. Their chemical structures were determined based on the spectroscopic data interpretation, particula ...
- DOI:
- 10.1016/j.phytol.2016.07.004
- https://doi.org/10.1016/j.phytol.2016.07.004
- Author:
- Santosh G. Tilve; Prachi S. Torney; Rupesh E. Patre; Durga P. Kamat; Bikshandarkoil R. Srinivasan; Fedor I. Zubkov
- Source:
- Tetrahedron letters 2016 v.57 pp. 2266-2268
- ISSN:
- 0040-4039
- Subject:
- acetates; chemical reactions; chemical structure; lignans
- Abstract:
- ... A convenient two step protocol for the synthesis of carbazole lignans involving Domino Wittig reaction/Diels Alder reaction followed by aromatization with DDQ is described. The main step of this protocol involves interaction between 2- or 3-indolecarboxyaldehydes and cinnamyl 2-(triphenylphosphoranylidene)acetates. ...
- DOI:
- 10.1016/j.tetlet.2016.04.038
- https://doi.org/10.1016/j.tetlet.2016.04.038
- Author:
- Yun-Song Wang; Zheng-Qi Wen; Bi-Tao Li; Hong-Bin Zhang; Jing-Hua Yang
- Source:
- Journal of ethnopharmacology 2016 v.181 pp. 66-107
- ISSN:
- 0378-8741
- Subject:
- Litsea; alkaloids; antioxidants; antiretroviral agents; central nervous system; chemical structure; clinical examination; data collection; databases; diabetes; diarrhea; essential oils; ethnobotany; evergreen trees; flavonoids; health services; inflammation; influenza; lactones; lignans; mechanism of action; medicinal properties; pain; product development; secondary metabolites; sesquiterpenoids; shrubs; stomach; therapeutics; toxicology; traditional medicine; vomiting; China; South America
- Abstract:
- ... The genus Litsea is one of the most diverse genera of evergreen trees or shrubs belong to Lauraceae, and comprises roughly 400 species of tree that are distributed abundantly throughout tropical and subtropical Asia, North and South America. Litsea species have been used globally in traditional medicine for the treatment of various diseases including influenza, stomach aches, diarrhea, diabetes, v ...
- DOI:
- 10.1016/j.jep.2016.01.032
- https://doi.org/10.1016/j.jep.2016.01.032
- Author:
- Ming Bai; Guo-Dong Yao; Si-Fan Liu; Di Wang; Qing-Bo Liu; Xiao-Xiao Huang; Shao-Jiang Song
- Source:
- Journal of functional foods 2017 v.28 pp. 106-113
- ISSN:
- 1756-4646
- Subject:
- Alzheimer disease; active ingredients; antioxidants; chemical structure; ethanol; functional foods; green leafy vegetables; lignans; molecular models; neuroprotective effect; salads; soups; spectral analysis; tetrahydrofuran; China; Japan; Korean Peninsula; North America
- Abstract:
- ... Patrinina villosa Juss. is a delicious wild vegetable, which is widely distributed in China, Korea, Japan and North America. P. villosa, which smells fresh and is highly nutritious, can be made into a salad, used as greens and as a porridge and soup. Phytochemical investigation of the 70% EtOH extract showed the presence of two dibenzylbutyrolactone lignans (1–2), named Patrinians (A-B), along wit ...
- DOI:
- 10.1016/j.jff.2016.10.024
- https://doi.org/10.1016/j.jff.2016.10.024
- Author:
- Yun-Su Baek; Kyeong-Hwa Seo; Dae-Young Lee; Oh-Keun Kwon; Nam-In Baek
- Source:
- Chemistry of natural compounds 2016 v.52 no.6 pp. 986-988
- ISSN:
- 0009-3130
- Subject:
- Magnolia obovata; chemical structure; ethyl acetate; fruits; lignans; spectral analysis
- Abstract:
- ... A new neolignan was isolated from the EtOAc fraction obtained from Magnolia obovata fruits. The chemical structure of the new neolignan was determined to be 5,5′-diallyl-2,2′-dihydroxybiphenyl ether (1), named isoobovatol, based on physicochemical and spectroscopic data including FT-NMR and EI-MS. ...
- DOI:
- 10.1007/s10600-016-1842-x
- https://doi.org/10.1007/s10600-016-1842-x
- Author:
- Karan Vasisht; Mahaveer Dhobi; Sadhika Khullar; Sanjay K. Mandal; Maninder Karan
- Source:
- Tetrahedron letters 2016 v.57 pp. 1758-1762
- ISSN:
- 0040-4039
- Subject:
- Clitoria ternatea; X-ray diffraction; acetylcholinesterase; chemical reactions; chemical structure; lignans; memory; nuclear magnetic resonance spectroscopy; roots; triterpenoids
- Abstract:
- ... Three new norneolignans, the clitorienolactones A–C along with a known triterpenoid, taraxerol were isolated from the roots of Clitoria ternatea L. The structures of clitorienolactones A–C were established on the basis of UV, IR, 1D and 2D NMR, and HRESIMS analyses and were further confirmed by X-ray crystallographic analysis of clitorienolactone A. The clitorienolactones A and B possess memory en ...
- DOI:
- 10.1016/j.tetlet.2016.03.024
- https://doi.org/10.1016/j.tetlet.2016.03.024
- Author:
- Suchand Basuli; Satyanarayana Gedu
- Source:
- Journal of organic chemistry 2017 v.82 no.1 pp. 372-381
- ISSN:
- 1520-6904
- Subject:
- acylation; aldehydes; catalytic activity; chemical structure; condensation reactions; lignans; organic chemistry; palladium; synthesis
- Abstract:
- ... An efficient, one-pot synthesis of substituted indenones was accomplished starting from simple o-iodoketones and aldehydes. [Pd]-catalyzed direct acylation of o-iodoketones with aldehydes was employed as the key step. Subsequent intramolecular aldol condensation afforded the indenones. Notably, a variety of indenones were achieved. Significantly, the natural product neolignan was accomplished in o ...
- DOI:
- 10.1021/acs.joc.6b02453
- https://doi.org/10.1021/acs.joc.6b02453
- Author:
- Liu Yongjun; Tian Guang; Li Jingjing; Qi Yan; Wen Yonghong; Du Feng
- Source:
- Journal of organic chemistry 2017 v.82 no.11 pp. 5932-5939
- ISSN:
- 1520-6904
- Subject:
- acrylates; additives; air; aldehydes; chemical reactions; chemical structure; copper; lignans; maleates; organic chemistry; potassium iodide; samarium; sieves
- Abstract:
- ... The novel bis-addition of benzaldehydes to acrylates or maleates was achieved by the direct use of samarium metal with the assistance of CuI under mild conditions under dry air, and the useful 2-hydroxylalkyl-γ-butyrolactons and lignan derivatives were thus constructed with high efficiency. The key factors that influence the reaction efficiency were investigated. The use of potassium iodide and mo ...
- DOI:
- 10.1021/acs.joc.7b00278
- https://doi.org/10.1021/acs.joc.7b00278
- Author:
- Huan Xiong; Fang Zhao; Jiayi Bi; Yang Zhang; Guiyun Zhao; Xue Chen; Yuncong Li; Rui Yan; Qiang Zhao; Hua Qiao; Guogang Zhang
- Source:
- Natural medicines 2016 v.70 no.3 pp. 673-678
- ISSN:
- 1340-3443
- Subject:
- Ilex pubescens; chemical structure; cytotoxicity; humans; in vitro studies; lignans; nuclear magnetic resonance spectroscopy; roots
- Abstract:
- ... A new phenylethanoid, 1-O-β-D-(4-hydroxyphenyl)-ethyl-6-O-vanilloyl-glucopyranoside (1), and a new furofuran lignan, (7R,7′R,7′′S,8S,8′S,8′′R)-4′, 4′′-dihydroxy-3,3′,3′′,5-tetramethoxy-7,9′:7′9-diepoxy-4,8′′-oxy-8,8′-sesquineolignan-7′′,9′′-diol (2), along with five known compounds (3–7) were isolated from the roots of Ilex pubescens. Their chemical structures were elucidated on the basis of exten ...
- DOI:
- 10.1007/s11418-016-0996-y
- https://doi.org/10.1007/s11418-016-0996-y
- Author:
- Yong-Mei Ren; Chang-Qiang Ke; Attila Mándi; Tibor Kurtán; Chunping Tang; Sheng Yao; Yang Ye
- Source:
- Tetrahedron 2017 pp. -
- ISSN:
- 0040-4020
- Subject:
- Vaccinium bracteatum; biochemical pathways; chemical reactions; chemical structure; circular dichroism spectroscopy; glucosides; iridoids; leaves; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
- Abstract:
- ... Two new lignan-iridoid glucoside diesters (2 and 3), together with their putative biosynthetic precursor 10-O-trans-caffeoyl-6α-hydroxyl-dihydromonotropein (1), were characterized from the leaves of Vaccinium bracteatum. Their planar structures and relative configuration were elucidated by spectroscopic measurements and DFT C NMR calculations, and their absolute configurations were determined by t ...
- DOI:
- 10.1016/j.tet.2017.04.040
- https://doi.org/10.1016/j.tet.2017.04.040
- Author:
- Kim Chung Sub; Subedi Lalita; Kwon Oh Wook; Park Hyun Bong; Kim Sun Yeou; Choi Sang Un; Lee Kang Ro
- Source:
- Journal of natural products 2016 v.79 no.10 pp. 2652-2657
- ISSN:
- 1520-6025
- Subject:
- Eutrema japonica; chemical structure; cytotoxicity; glycosides; humans; lignans; mice; neoplasm cells; nerve growth factor; neuroglia; neuroprotective effect; nitric oxide; roots; spectral analysis
- Abstract:
- ... Five new lignan glycosides, wasabisides A–E (1–5), and four known phenolic compounds (6–9), were isolated from the roots of Wasabia japonica. The chemical structures of the new compounds (1–5) were determined through spectroscopic analysis and chemical methods. All isolated compounds (1–9) were evaluated for their potential neuroprotective effects through induction of nerve growth factor in C6 gli ...
- DOI:
- 10.1021/acs.jnatprod.6b00582
- https://doi.org/10.1021/acs.jnatprod.6b00582
- Author:
- Toshiro Noshita; Kohei Matsumoto; Hikaru Nishikawa; Hidekazu Ouchi; Yoshitomo Hamada; Akiko Saito; Teiko Yamada
- Source:
- Natural product research 2017 v.31 no.2 pp. 163-168
- ISSN:
- 1478-6427
- Subject:
- chemical reactions; chemical structure; copper; diphenyl ethers; lignans; spectral analysis
- Abstract:
- ... We describe the synthesis of 4,4′-oxyneolignan, the proposed structure for naturally occurring apteniol D. The diphenyl ether moiety in 4,4′-oxyneolignan was formed via classical Ullmann ether synthesis using excess copper powder in N,N -dimethylacetamide. The spectral data of synthesised apteniol D show differences compared to those of naturally occurring apteniol D. ...
- DOI:
- 10.1080/14786419.2016.1224867
- https://doi.org/10.1080/14786419.2016.1224867
- Author:
- Truc T.T. Duong; Truong N.V. Do; Hai X. Nguyen; Tho H. Le; Phu H. Dang; Nhan T. Nguyen; Tuyen N.T. Nguyen; Thao D. Nguyen; Mai T.T. Nguyen
- Source:
- Tetrahedron letters 2017 pp. -
- ISSN:
- 0040-4039
- Subject:
- Mangifera; acarbose; alpha-glucosidase; biochemical pathways; chemical reactions; chemical structure; inhibitory concentration 50; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
- Abstract:
- ... Two new neolignans, named rebaneolignan A (1) and B (2), were isolated from the stem of Mangifera reba (Anacardiaceae), together with six known compounds (3–8). Their structures were elucidated on the basis of NMR spectroscopic analysis and the absolute configurations of 1 and 2 were determined by NOESY and CD data. All isolated compounds were found to possess more potent inhibitory activity, with ...
- DOI:
- 10.1016/j.tetlet.2017.04.092
- https://doi.org/10.1016/j.tetlet.2017.04.092
- Author:
- Ki Hyun Kim; Jon Clardy; Donald Senger; Shugeng Cao
- Source:
- Tetrahedron letters 2015 v.56 no.21 pp. 2732-2734
- ISSN:
- 0040-4039
- Subject:
- Barleria; aerial parts; chemical reactions; chemical structure; lignans; spectral analysis
- Abstract:
- ... Two novel 4,8,8-trimethylcyclooct-2-enone derivatives, chakyunglupulins A and B, together with six known lignans were isolated from the aerial part of Barleria lupulina. The structures of new compounds were established by extensive spectroscopic data and HR-MS, and their absolute configurations were determined by a combination of NOE experiment and application of the modified Mosher’s method. ...
- DOI:
- 10.1016/j.tetlet.2015.04.023
- PubMed:
- 26240452
- PubMed Central:
- PMC4521596
- https://doi.org/10.1016/j.tetlet.2015.04.023
- Author:
- Axel Marchal; Blandine N. Cretin; Lauriane Sindt; Pierre Waffo-Téguo; Denis Dubourdieu
- Source:
- Tetrahedron 2015 v.71 pp. 3148-3156
- ISSN:
- 0040-4020
- Subject:
- Quercus petraea; bitterness; chemical reactions; chemical structure; detection limit; heartwood; lignans; quantitative analysis; sensory evaluation; taste; wines; wood
- Abstract:
- ... The modification of wine taste during oak ageing is due to the release of non-volatile compounds from wood. Among these molecules, some lignans have been previously described as exhibiting bitterness. However, the lack of knowledge concerning this class of compounds in oak wood led us to explore both their structural diversity and their sensory properties. Nine lignans were isolated from extracts ...
- DOI:
- 10.1016/j.tet.2014.07.090
- https://doi.org/10.1016/j.tet.2014.07.090
- Author:
- Lee Eunhye; Bang Jiyun; Kwon Jisook; Yu Chan-Mo
- Source:
- Journal of organic chemistry 2015 v.80 no.20 pp. 10359-10363
- ISSN:
- 1520-6904
- Subject:
- chemical reactions; chemical structure; enantioselective synthesis; enantioselectivity; lignans; organic chemistry; tetrahydrofuran
- Abstract:
- ... A synthesis of natural tetrahydrofuran lignan (+)-sylvone is achieved starting from methyl allenoate in 5 steps. The synthesis begins from an enantioselective aldol reaction of methyl allenoate with 3,4-dimethoxybenzaldehyde to afford α-addition aldol adduct. Key steps for the synthesis of sylvone include an oxacyclization of the α-hydroxy allenyl adduct followed by a Michael addition of a 1,3-dit ...
- DOI:
- 10.1021/acs.joc.5b01677
- https://doi.org/10.1021/acs.joc.5b01677
- Author:
- Pilkington Lisa I.; Wagoner Jessica; Polyak Stephen J.; Barker David
- Source:
- Organic letters 2015 v.17 no.4 pp. 1046-1049
- ISSN:
- 1523-7052
- Subject:
- chemical reactions; chemical structure; enantioselective synthesis; lignans; models; stereochemistry
- Abstract:
- ... The enantioselective synthesis and chiroptic analysis of all members of the rodgersinine family of 1,4-benzodioxane neolignans has been achieved. ECD spectra and optical rotation analysis determined that the previously published stereochemistry of trans-rodgersinines A and B was incorrect. The cis-rodgersinines A and B did not follow the model ECD study commonly used to assign the absolute stereoc ...
- DOI:
- 10.1021/acs.orglett.5b00189
- https://doi.org/10.1021/acs.orglett.5b00189
- Author:
- Ye-Jin Jung; Ji-Hae Park; Jin-Gyeong Cho; Kyeong-Hwa Seo; Dong-Sung Lee; Youn-Chul Kim; Hee-Cheol Kang; Myoung-Chong Song; Nam-In Baek
- Source:
- Archives of pharmacal research 2015 v.38 no.2 pp. 178-185
- ISSN:
- 0253-6269
- Subject:
- Zea mays; anti-inflammatory activity; butanol; cell death; chemical structure; corn stover; ethyl acetate; flavonoids; lignans; lipopolysaccharides; macrophages; methanol; neuroprotective effect; nitric oxide; nuclear magnetic resonance spectroscopy; stems
- Abstract:
- ... The stems of Zea mays L., otherwise known as cornstalks, were extracted with 80 % aqueous MeOH, and the concentrated extract was successively partitioned with ethyl acetate (EtOAc), normal butanol, and water. From the EtOAc fraction, a new lignan along with three known flavonoids, tricin (1), salcolin A (2), and salcolin B (3), were isolated. The chemical structure of the lignan was determined to ...
- DOI:
- 10.1007/s12272-014-0387-4
- https://doi.org/10.1007/s12272-014-0387-4
- Author:
- Gui-Yun Cao; Wei Xu; Xiu-Wei Yang; Frank J. Gonzalez; Fei Li
- Source:
- Food chemistry 2015 v.173 pp. 231-237
- ISSN:
- 0308-8146
- Subject:
- Myristica fragrans; anti-inflammatory agents; chemical structure; inducible nitric oxide synthase; inhibitory concentration 50; lignans; messenger RNA; nitric oxide; quantitative polymerase chain reaction; seeds; spectroscopy
- Abstract:
- ... Five new 8-O-4′ type neolignans, named myrifralignan A–E (1–5), together with five known analogues (6–10), were isolated from the seeds of Myristica fragrans Houtt. Their chemical structures were determined using several spectroscopic methods. Compounds 3–10 exhibited potent inhibitory activity against the production of nitric oxide (NO) in the RAW264.7 cell line stimulated by lipopolysaccaride. M ...
- DOI:
- 10.1016/j.foodchem.2014.09.170
- PubMed:
- 25466017
- PubMed Central:
- PMC6338084
- https://doi.org/10.1016/j.foodchem.2014.09.170
- Author:
- Lee Ik-Soo; Jung Seung-Hyun; Lee Yun Mi; Choi So-Jin; Sun Hang; Kim Jin Sook
- Source:
- Journal of natural products 2015 v.78 no.9 pp. 2249-2254
- ISSN:
- 1520-6025
- Subject:
- Danio rerio; Osteomeles; aldehyde reductase; branches; chemical structure; enzyme inhibition; eye lens; glucose; glycosides; inhibitory concentration 50; larvae; leaves; lignans; rats; spectral analysis
- Abstract:
- ... Three new phenolic biphenyl derivatives (1–3) and one new lignan glycoside (4) were isolated from the leaves and twigs of Osteomeles schwerinae. The structures of the new compounds were established by spectroscopic data interpretation. The inhibitory effects of 1–4 on rat lens aldose reductase in vitro were examined, and compounds 1–3 markedly inhibited the enzyme with IC₅₀ values of 3.8 to 13.8 μ ...
- DOI:
- 10.1021/acs.jnatprod.5b00469
- https://doi.org/10.1021/acs.jnatprod.5b00469
- Author:
- Naresh Gunaganti; Kant Ruchir; Narender Tadigoppula
- Source:
- Organic letters 2015 v.17 no.14 pp. 3446-3449
- ISSN:
- 1523-7052
- Subject:
- alkynes; chemical reactions; chemical structure; lignans; regioselectivity; silver; solvents
- Abstract:
- ... A novel route has been developed for regioselective synthesis of highly substituted α-naphthols, binaphthols, and anthracenol through silver(I) catalyzed C(sp³)–H/C(sp)–H, C(sp²)–H/C(sp)–H functionalization of β-ketoesters and alkynes, respectively, in a single step using water as a solvent. This protocol exhibited broad substrate scope and paved the way for synthesis of anticancer arylnaphthalene ...
- DOI:
- 10.1021/acs.orglett.5b01477
- https://doi.org/10.1021/acs.orglett.5b01477
- Author:
- Seijiro Takada; Kiitsu Iwata; Toshihide Yubune; Yoshinori Nishii
- Source:
- Tetrahedron letters 2016 v.57 pp. 2422-2425
- ISSN:
- 0040-4039
- Subject:
- chemical reactions; chemical structure; lactones; lignans; phenols; stereochemistry
- Abstract:
- ... Stereoselective oxy-homo-Michael (OHM) addition of alcohols, phenols, and carboxylic acid to optically active bicyclic donor–acceptor cyclopropanes such as (1S,5R,6S)-6-aryl-1-methoxycarbonyl-3-oxabicyclo[3,1,0]hexan-2-ones proceeded to give trans-α,β-disubstituted γ-butyrolactones, which possess three serial chiral centers, in good to high yields with excellent dr and ee. Increasing the loading o ...
- DOI:
- 10.1016/j.tetlet.2016.04.076
- https://doi.org/10.1016/j.tetlet.2016.04.076
- Author:
- Faisal Hayat; Lien Kang; Chang-Yong Lee; Dongyun Shin
- Source:
- Tetrahedron 2015 v.71 pp. 2945-2950
- ISSN:
- 0040-4020
- Subject:
- antiviral properties; chemical reactions; chemical structure; lactones; lignans; naphthalene
- Abstract:
- ... Arylnaphthalene lactones, which are natural lignans and isolated from a wide range of plants, exhibit significant biological activity, including anticancer and antiviral activities. In this work, we have developed a versatile and convergent synthetic method for arylnaphthalene lactones, which involves the use of benzoin condensation and thermal intramolecular cyclization for preparing the key inte ...
- DOI:
- 10.1016/j.tet.2015.03.023
- https://doi.org/10.1016/j.tet.2015.03.023
- Author:
- Eun-Kyung Jung; Nora Dittrich; Lisa I. Pilkington; Claire E. Rye; Euphemia Leung; David Barker
- Source:
- Tetrahedron 2015 v.71 pp. 9439-9456
- ISSN:
- 0040-4020
- Subject:
- active ingredients; breast neoplasms; chemical reactions; chemical structure; humans; inhibitory concentration 50; lignans; morpholine; tetrahydrofuran
- Abstract:
- ... The synthesis of novel aza-derivatives of THF lignan natural products has been achieved. This synthesis originates in the use of a highly selective acyl-Claisen reaction to provide a syn morpholine amide which ultimately determines a trans relationship at the 3- and 4-positions on the central ring. Initial attempts at the synthesis resulted in premature cyclisation, producing either dihydro-pyrrol ...
- DOI:
- 10.1016/j.tet.2015.10.050
- https://doi.org/10.1016/j.tet.2015.10.050
- Author:
- Nai-Dan Zhang; Ting Han; Bao-Kang Huang; Khalid Rahman; Yi-Ping Jiang; Hong-Tao Xu; Lu-Ping Qin; Hai-Liang Xin; Qiao-Yan Zhang; Yi-min Li
- Source:
- Journal of ethnopharmacology 2016 v.189 pp. 61-80
- ISSN:
- 0378-8741
- Subject:
- Oriental traditional medicine; active ingredients; animal experimentation; chemical structure; databases; flavonoids; herbal medicines; herbs; iridoid glycosides; lignans; mechanism of action; mitogen-activated protein kinase; mothers against decapentaplegic homolog proteins; osteoblasts; osteoclasts; osteoporosis; saponins; therapeutics
- Abstract:
- ... Osteoporosis is a chronic epidemic which can leads to enhanced bone fragility and consequent an increase in fracture risk. Traditional Chinese medicine (TCM) formulas have a long history of use in the prevention and treatment of osteoporosis. Antiosteoporotic TCM formulas have conspicuous advantage over single drugs. Systematic data mining of the existing antiosteoporotic TCM formulas database can ...
- DOI:
- 10.1016/j.jep.2016.05.025
- https://doi.org/10.1016/j.jep.2016.05.025
- Author:
- Kanok-on Rayanil; Wirunya Sutassanawichanna; Oranart Suntornwat; Pittaya Tuntiwachwuttikul
- Source:
- Natural product research 2016 v.30 no.23 pp. 2675-2681
- ISSN:
- 1478-6427
- Subject:
- Annonaceae; acarbose; acetates; acids; alpha-glucosidase; chemical structure; enzyme inhibition; enzyme inhibitors; hypoglycemic agents; leaves; lignans; nuclear magnetic resonance spectroscopy; spectral analysis
- Abstract:
- ... A new dihydrobenzofuran lignan, (2 R ,3 S)-2-(3′,4′-dimethoxyphenyl)-5-(3-hydroxypropyl)-7-methoxy-2,3-dihydrobenzofuran-3-methyl acetate, named as mitredrusin (1), was isolated from the leaves of Mitrephora teysmannii (Annonaceae) together with 12 known compounds including a related dihydrobenzofuran lignan: (−)-3′,4-di- O -methylcedrusin (2), four polyacetylenic acids: 13(E)-octadecene-9,11-diyn ...
- DOI:
- 10.1080/14786419.2016.1143830
- https://doi.org/10.1080/14786419.2016.1143830
- Author:
- Thi Hoai Nguyen; Viet Duc Ho; Thi Thao Do; Huu Tai Bui; Van Kiem Phan; Katrin Sak; Ain Raal
- Source:
- Natural product research 2015 v.29 no.3 pp. 247-252
- ISSN:
- 1478-6427
- Subject:
- Uvaria; adenocarcinoma; aerial parts; catechin; chemical structure; cytotoxicity; epicatechin; glycosides; humans; lignans; nuclear magnetic resonance spectroscopy; Vietnam
- Abstract:
- ... Chemical investigation of the aerial parts of Uvaria rufa (Dunal) Blume collected from Vietnam yielded one new lignan glycoside, ufaside (1), along with six known compounds, oxoanolobine (2), ergosta-4,6,8(14),22-tetraen-3-one (3), catechin (4), epicatechin (5), daucosterol (6) and glutin-5-en-3-one (7). Their chemical structures were determined by using NMR, HR-MS spectroscopic analyses and in co ...
- DOI:
- 10.1080/14786419.2014.971790
- https://doi.org/10.1080/14786419.2014.971790
- Author:
- Liu Yixi; Young Kelly; Rakotondraibe L. Harinantenaina; Brodie Peggy J.; Wiley Jessica D.; Cassera Maria B.; Callmander Martin W.; Rakotondrajaona R.; Rakotobe Etienne; Rasamison Vincent E.; TenDyke Karen; Shen Yongchun; Kingston David G. I.
- Source:
- Journal of natural products 2015 v.78 no.7 pp. 1543-1547
- ISSN:
- 1520-6025
- Subject:
- Cleistanthus; anticarcinogenic activity; chemical structure; colorectal neoplasms; humans; inhibitory concentration 50; lignans; melanoma; metastasis; neoplasm cells; ovarian neoplasms; spectroscopy; Madagascar
- Abstract:
- ... The two new lignans 3α-O-(β-d-glucopyranosyl)desoxypodophyllotoxin (1) and 4-O-(β-d-glucopyranosyl)dehydropodophyllotoxin (2) were isolated from Cleistanthus boivinianus, together with the known lignans deoxypicropodophyllotoxin (3), (±)-β-apopicropodophyllin (4), (−)-desoxypodophyllotoxin (5), (−)-yatein (6), and β-peltatin-5-O-β-d-glucopyranoside (7). The structures of all compounds were charact ...
- DOI:
- 10.1021/np501020m
- PubMed:
- 26091020
- PubMed Central:
- PMC4517784
- CHORUS:
- 10.1021/np501020m
- Chorus Open Access:
- 10.1021/np501020m
- https://doi.org/10.1021/np501020m
- Author:
- Li Huilin; Zhang Yuanyuan; Xie Xingang; Ma Haichen; Zhao Changgui; Zhao Gaoyuan; She Xuegong
- Source:
- Organic letters 2014 v.16 no.17 pp. 4440-4443
- ISSN:
- 1523-7052
- Subject:
- biochemical pathways; chemical reactions; chemical structure; lignans; phenol
- Abstract:
- ... Bioinspired total synthesis of gymnothelignan N was accomplished in 13 steps and 6.7% overall yield. The synthesis features a syn Evans aldol reaction, an intramolecular hydrogenative dehydration reaction, and a phenol oxidative dearomatization/Friedel–Crafts reaction, which provides a new plausible biosynthetic pathway for the gymnothelignans and other symbiotic members. Meanwhile, another tetrah ...
- DOI:
- 10.1021/ol501960j
- https://doi.org/10.1021/ol501960j
- Author:
- Jin Hyo Kim; Woo Duck Seo; Seong Kyu Lee; Yong Bok Lee; Choon Hwa Park; Hyung Won Ryu; Jin Hwan Lee
- Source:
- Journal of functional foods 2014 v.7 pp. 495-505
- ISSN:
- 1756-4646
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Sesamum indicum; acetonitrile; antioxidant activity; chemical structure; color; cultivars; lignans; nuclear magnetic resonance spectroscopy; oils; seeds; sesame seed; solvents
- Abstract:
- ... The compositional components (lignan, protein, and oil) as well as antioxidant properties of white and black sesame seeds from different crop years were evaluated. Various solvent extracts of sesame seeds possessed two major peaks and their chemical structures were confirmed as sesamin (1) and sesamolin (2) using NMR spectroscopy and HPLC–DAD–ESI/MS technique. Moreover, their optimal extraction wa ...
- DOI:
- 10.1016/j.jff.2014.01.006
- https://doi.org/10.1016/j.jff.2014.01.006
- Author:
- Kocsis Laura S.; Brummond Kay M.
- Source:
- Organic letters 2014 v.16 no.16 pp. 4158-4161
- ISSN:
- 1523-7052
- Subject:
- chemical reactions; chemical structure; lactones; lignans; solvents
- Abstract:
- ... Intramolecular dehydro-Diels–Alder (DDA) reactions are performed affording arylnaphthalene or aryldihydronaphthalene lactones selectively as determined by choice of reaction solvent. This constitutes the first report of an entirely selective formation of arylnaphthalene lactones utilizing DDA reactions of styrene-ynes. The synthetic utility of the DDA reaction is demonstrated by the synthesis of t ...
- DOI:
- 10.1021/ol501853y
- PubMed:
- 25061845
- PubMed Central:
- PMC4136723
- https://doi.org/10.1021/ol501853y
- Author:
- Kim Chung Sub; Subedi Lalita; Kim Sun Yeou; Choi Sang Un; Kim Ki Hyun; Lee Kang Ro
- Source:
- Journal of natural products 2015 v.78 no.5 pp. 1174-1178
- ISSN:
- 1520-6025
- Subject:
- Pseudocydonia sinensis; bioactive properties; branches; chemical structure; gas chromatography-mass spectrometry; glycosides; inhibitory concentration 50; lignans; mice; nerve growth factor; neuroglia; nitric oxide; nuclear magnetic resonance spectroscopy; rats; secretion
- Abstract:
- ... Phytochemical investigation of the twigs of Chaenomeles sinensis led to the isolation and identification of six new lignan glycosides, chaenomiside A–F (1–6), along with five known ones (7–11). Their chemical structures were determined by spectroscopic methods, including NMR, MS, ECD, and GC/MS analyses. All the isolated compounds (1–11) were tested for their inhibitory effects on nitric oxide (NO ...
- DOI:
- 10.1021/acs.jnatprod.5b00090
- https://doi.org/10.1021/acs.jnatprod.5b00090
- Author:
- Yan-Ni Shi; Yi-Ming Shi; Lian Yang; Xing-Cong Li; Jin-Hua Zhao; Yan Qu; Hong-Tao Zhu; Dong Wang; Rong-Rong Cheng; Chong-Ren Yang; Min Xu; Ying-Jun Zhang
- Source:
- Journal of ethnopharmacology 2015 v.162 pp. 87-96
- ISSN:
- 0378-8741
- Subject:
- Danio rerio; Piper wallichii; acid hydrolysis; active ingredients; air drying; aldehydes; aspirin; biphenyl; blood; chemical structure; circular dichroism spectroscopy; density functional theory; glycosides; high performance liquid chromatography; infarction; inhibitory concentration 50; lignans; medicinal plants; models; platelet aggregation; platelet-activating factor; rheumatoid arthritis; spectral analysis; stems; traditional medicine; China
- Abstract:
- ... Piper wallichii (Miq.) Hand.-Mazz. is a medicinal plant used widely for the treatment of rheumatoid arthritis, inflammatory diseases, cerebral infarction and angina in China. Previous study showed that lignans and neolignans from Piper spp. had potential inhibitory activities on platelet aggregation. In the present study, we investigated the chemical constituents of Piper wallichii and their antit ...
- DOI:
- 10.1016/j.jep.2014.12.038
- https://doi.org/10.1016/j.jep.2014.12.038
- Author:
- Seo-Ji In; Kyeong-Hwa Seo; Na-Young Song; Dong-Sung Lee; Youn-Chul Kim; Nam-In Baek
- Source:
- Archives of pharmacal research 2015 v.38 no.1 pp. 26-34
- ISSN:
- 0253-6269
- Subject:
- Viburnum; alcohols; anti-inflammatory activity; cell death; chemical structure; chromatography; lignans; neuroprotective effect; nitric oxide; nuclear magnetic resonance spectroscopy; silica gel; stems
- Abstract:
- ... A new lignan, (7′S,8S,8′S)-3,5′-dimethoxy-3′,4,9′-trihydroxy-7′,9-epoxy-8,8′-lignan, named vibruresinol (1), was isolated from the stems of Viburnum erosum by silica gel, ODS, and Sephadex LH-20 column chromatography. In addition, four other known lignans, (7′R,8S,8′S)-3,5′-dimethoxy-3′,4,8′,9′-tetrahydroxy-7′,9-epoxy-8,8′-lignan (2), (+)-syringaresinol (3), (+)-pinoresinol (4), and (+)-pinoresino ...
- DOI:
- 10.1007/s12272-014-0358-9
- https://doi.org/10.1007/s12272-014-0358-9
- Author:
- László Juhász; Zoltán Dinya; Sándor Antus; Tamás E. Gunda
- Source:
- Zeitschrift für Naturforschung 2014 v.56 no.6 pp. 554
- ISSN:
- 0932-0776
- Subject:
- bioactive properties; chemical reactions; chemical structure; lignans; synthesis
- Abstract:
- ... A new synthesis of the racemates of two naturally occurring neolignans 1 and 2 was achieved via the 2,3-dihydrobenzo[b]furan derivative 3, starting from the commercially available materials o-vanillin (6) and acetovanillone (9). ...
- DOI:
- 10.1515/znb-2001-0612
- https://doi.org/10.1515/znb-2001-0612
- Author:
- Qing Ma; Haihui Xie; Yueming Jiang; Xiaoyi Wei
- Source:
- Journal of functional foods 2014 v.9 pp. 156-161
- ISSN:
- 1756-4646
- Subject:
- benzophenones; sesquiterpenoids; pericarp; 2,2-diphenyl-1-picrylhydrazyl; Litchi chinensis; chemical structure; lignans; antioxidant activity; spectroscopy; antioxidants; metabolites
- Abstract:
- ... The pericarp of Litchi chinensis was reported to be a rich source of antioxidants. This study aimed to identify the chemical structures present in litchi pericarp with antioxidant activity. Four lignans, (+)-isolariciresinol 9-O-α-l-arabinopyranoside (1), burselignan 9-O-α-l-arabinopyranoside (2), (−)-secoisolariciresinol 9-O-α-l-arabinopyranoside (3), and sisymbrifolin (4), a chromane, 2α-methoxy ...
- DOI:
- 10.1016/j.jff.2014.04.020
- https://doi.org/10.1016/j.jff.2014.04.020
- Author:
- Cui Hui; Xu Bo; Wu Taizong; Xu Jun; Yuan Yan; Gu Qiong
- Source:
- Journal of natural products 2014 v.77 no.1 pp. 100-110
- ISSN:
- 1520-6025
- Subject:
- fractionation; antiviral properties; humans; cytotoxicity; Saururus chinensis; viruses; lignans; pathogenesis; median effective concentration; roots; chemical structure; Human gammaherpesvirus 4
- Abstract:
- ... Epstein–Barr virus (EBV) is a member of the γ-herpes virus subfamily and has been implicated in the pathogenesis of several human malignancies. Bioassay-guided fractionation was conducted on an EtOAc-soluble extract of the roots of Saururus chinensis and monitored using an EBV lytic replication assay. This led to the isolation of 19 new (1–19) and nine known (20–28) lignans. The absolute configura ...
- DOI:
- 10.1021/np400757k
- https://doi.org/10.1021/np400757k
- Author:
- Teerayut Sriyatep; Suda Chakthong; Sukanlaya Leejae; Supayang P. Voravuthikunchai
- Source:
- Tetrahedron 2014 v.70 pp. 1773-1779
- ISSN:
- 0040-4020
- Subject:
- alkaloids; biochemical pathways; branches; chemical reactions; chemical structure; cytotoxicity; flavanones; inhibitory concentration 50; lignans; neoplasms; spectroscopy
- Abstract:
- ... Four new compounds, two lignans; lucidenal and lucidanin (1 and 2), one alkaloid (3), and one flavanone (4) together with 26 known compounds (5–30), were isolated from the twigs of Feroniella lucida. The structures of the new compounds were determined on the basis of spectroscopic analyses. Lucidenal 1 showed cytotoxicity against HuCCA-1, A549, MOLT-3 and HepG2 cancer cell lines with IC50 values o ...
- DOI:
- 10.1016/j.tet.2014.01.023
- https://doi.org/10.1016/j.tet.2014.01.023
- Author:
- Yan-Ping Gao; Yun-Heng Shen; Xi-Ke Xu; Jun-Mian Tian; Hua-Wu Zeng; Sheng Lin; Chun-Mei Liu; Wei-Dong Zhang
- Source:
- Journal of Asian natural products research 2014 v.16 no.7 pp. 724-729
- ISSN:
- 1477-2213
- Subject:
- Gaultheria; anti-inflammatory activity; chemical structure; interleukin-6; lignans; macrophages; nitric oxide; nuclear magnetic resonance spectroscopy; tumor necrosis factor-alpha
- Abstract:
- ... Two new lignans, 9-salicyl-(+)-isolariciresinol (1) and gaultheroside G (2), together with seven known compounds, were isolated from the ethanolic extract of the whole plant of Gaultheria yunnanensis . Their structures were determined by extensive NMR and MS analyses. Gaultheroside G (2) was found to have an unusual ether linkage between the 2 and 9′ positions of aryl-tetralin lignan skeleton. All ...
- DOI:
- 10.1080/10286020.2014.898634
- https://doi.org/10.1080/10286020.2014.898634
- Author:
- Shi-Ji Xiao; Xin-Xiang Lei; Bing Xia; Dan-Qing Xu; Hong-Ping Xiao; Hong-Xi Xu; Fang Chen; Li-Sheng Ding; Yan Zhou
- Source:
- Tetrahedron letters 2014 v.55 no.43 pp. 5949-5951
- ISSN:
- 0040-4039
- Subject:
- antiviral properties; chemical reactions; chemical structure; indigenous species; inhibitory concentration 50; lignans; plants (botany); spectral analysis
- Abstract:
- ... Two novel lignans, gymnothespirolignans A (1) and B (2), possessing a rare polycyclic spiro skeleton, were isolated from the endemic plant of Gymnotheca involucrata Pei. Their structures were determined by spectroscopic evidences and the absolute configurations were confirmed by single crystal X-ray diffraction analysis. Compounds 1 and 2 showed promising antiviral activities against RSV with an I ...
- DOI:
- 10.1016/j.tetlet.2014.09.044
- https://doi.org/10.1016/j.tetlet.2014.09.044
- Author:
- Yang Jin; Liang Qian; Wang Mei; Jeffries Cynthia; Smithson David; Tu Ying; Boulos Nidal; Jacob Melissa R.; Shelat Anang A.; Wu Yunshan; Ravu Ranga Rao; Gilbertson Richard; Avery Mitchell A.; Khan Ikhlas A.; Walker Larry A.; Guy R. Kiplin; Li Xing-Cong
- Source:
- Journal of natural products 2014 v.77 no.4 pp. 902-909
- ISSN:
- 1520-6025
- Subject:
- Eriodictyon; Thuja occidentalis; X-ray diffraction; active ingredients; bark; chemical structure; databases; diterpenoids; fractionation; hesperetin; leaves; lignans; spectral analysis
- Abstract:
- ... The generation of natural product libraries containing column fractions, each with only a few small molecules, using a high-throughput, automated fractionation system, has made it possible to implement an improved dereplication strategy for selection and prioritization of leads in a natural product discovery program. Analysis of databased UPLC-MS-ELSD-PDA information of three leads from a biologic ...
- DOI:
- 10.1021/np4009706
- PubMed:
- 24617915
- PubMed Central:
- PMC4784093
- https://doi.org/10.1021/np4009706
- Author:
- Yi-Xing Li; Wen-Jian Zuo; Xiao-Na Li; Wen-Li Mei; Hao-Fu Dai
- Source:
- Journal of Asian natural products research 2014 v.16 no.5 pp. 549-553
- ISSN:
- 1477-2213
- Subject:
- chemical structure; glycosides; lignans; nuclear magnetic resonance spectroscopy; stems
- Abstract:
- ... Phytochemical investigation on the stems of Trigonostemon heterophyllus led to the isolation of a new lariciresinol-based lignan glycoside, trigonoheteran (1), together with a known lignan glycoside, aviculin (2). Their structures were elucidated by spectroscopic methods including 1D and 2D NMR (HMQC, ¹H– ¹H COSY, HMBC, and NOESY). ...
- DOI:
- 10.1080/10286020.2014.914503
- https://doi.org/10.1080/10286020.2014.914503
- Author:
- Hyun Gyu Choi; Yeon Ho Choi; Ji Hyang Kim; Hui-Hun Kim; Sang-Hyun Kim; Jeong Ah Kim; Sang Myung Lee; MinKyun Na; Seung Ho Lee
- Source:
- Archives of pharmacal research 2014 v.37 no.4 pp. 467-472
- ISSN:
- 0253-6269
- Subject:
- Lindera; anti-inflammatory activity; chemical analysis; chemical structure; esterification; genes; histamine; humans; interleukin-6; lignans; mast cells; medicinal plants; spectroscopy; stems; tumor necrosis factor-alpha
- Abstract:
- ... A new neolignan, linderin A (1), together with six known lignans, (+)-xanthoxyol (2), pluviatilol (3), actiforin (4), (+)-syringaresinol (5), (+)-(7S,8R,8′R)-acuminatolide (6), and (+)-9′-O-trans-feruloyl-5,5′-dimethoxylariciresinol (7) were isolated from the stems of Lindera obtusiloba Blume (Lauraceae). Their chemical structures were elucidated by a combination of spectroscopic analysis and chem ...
- DOI:
- 10.1007/s12272-013-0239-7
- https://doi.org/10.1007/s12272-013-0239-7
- Author:
- Darunee Soorukram; Jaray Panmuang; Patoomratana Tuchinda; Chutima Kuhakarn; Vichai Reutrakul; Manat Pohmakotr
- Source:
- Tetrahedron 2014 v.70 pp. 7577-7583
- ISSN:
- 0040-4020
- Subject:
- chemical reactions; chemical structure; lignans; stereochemistry
- Abstract:
- ... A stereoselective approach to secolignans is described. The key synthetic strategy involves an asymmetric aldol reaction to control the creation of the stereogenic center at the β-carbon of the target secolignans. In the present work, peperomin C and its analogues, i.e., 2,6-didehydropeperomin C and 2-epi-peperomin C were successfully synthesized in good yields with high stereoselectivities. ...
- DOI:
- 10.1016/j.tet.2014.07.101
- https://doi.org/10.1016/j.tet.2014.07.101
- Author:
- Deepti Yadav; Nusrat Masood; Suaib Luqman; Pemaiah Brindha; Madan M. Gupta
- Source:
- Industrial crops and products 2013 v.41 pp. 397-402
- ISSN:
- 0926-6690
- Subject:
- Premna; acids; antioxidant activity; bark; catalpol; chemical structure; free radical scavengers; lignans; nuclear magnetic resonance spectroscopy; stems
- Abstract:
- ... Two new furofuran lignans premnadimer (1) and 4β-hydroxyasarinin-1-O-β-glucopyranoside (2) along with 9 known compounds have been isolated from the stem bark of Premna integrifolia. Their chemical structures were elucidated using detailed spectroscopic studies. Their relative configurations were established using analysis of NOESY correlations and coupling constants observed in 1H NMR. Compounds 1 ...
- DOI:
- 10.1016/j.indcrop.2012.04.044
- https://doi.org/10.1016/j.indcrop.2012.04.044
- Author:
- Saumen Hajra; Abhisek Mandal; Sunit Hazra
- Source:
- Tetrahedron letters 2013 v.54 pp. 2171-2173
- ISSN:
- 0040-4039
- Subject:
- alkylation; chemical structure; lignans
- Abstract:
- ... A competent and general asymmetric synthesis of 7′-hydroxydibenzylbutyrolactone lignans such as (7′S)-hydroxymatairesinol and (7′S)-hydroxyarctigenin has been reported from N-succinyl-2-oxazolidinone in six steps where diastereoselective aldol reaction and stereoselective alkylation serve as the key steps. ...
- DOI:
- 10.1016/j.tetlet.2013.02.044
- https://doi.org/10.1016/j.tetlet.2013.02.044
- Author:
- Ying Huang; Yan-Li Hao; Xiao-Yan Mai
- Source:
- Journal of Asian natural products research 2013 v.15 no.4 pp. 319-324
- ISSN:
- 1477-2213
- Subject:
- Solidago canadensis; chemical composition; chemical structure; hamsters; high fat diet; lignans; lipemic effect; nuclear magnetic resonance spectroscopy; spectral analysis
- Abstract:
- ... Two new compounds, 8-dehydroxymethylvisanol (1) and 9-O-[3-O-acetyl-β-d-glucopyranosyl]-4-hydroxy-cinnamic acid (4), together with two known lignans, visanol (2) and 9-aldehydevibsanol (3), were isolated from the 80% EtOH extract of Solidago canadensis. The structures of the two new compounds were elucidated on the basis of 1D, 2D NMR, and mass spectral analysis. All the lignans exhibited moderate ...
- DOI:
- 10.1080/10286020.2012.753059
- https://doi.org/10.1080/10286020.2012.753059
100. Lignans from the Fruit of Schisandra glaucescens with Antioxidant and Neuroprotective Properties
- Author:
- Yu Heng-Yi; Chen Zu-Yu; Sun Bin; Liu Junjun; Meng Fan-Yu; Liu Ye; Tian Tian; Jin An; Ruan Han-Li
- Source:
- Journal of natural products 2014 v.77 no.6 pp. 1311-1320
- ISSN:
- 1520-6025
- Subject:
- 2,2-diphenyl-1-picrylhydrazyl; Schisandra; antioxidant activity; antioxidants; cell death; chemical structure; circular dichroism spectroscopy; glycosides; hydrolysis; inhibitory concentration 50; lignans; neuroprotective effect
- Abstract:
- ... Two rare 7,8-seco-lignans (1, 2), three new lignan glycosides (3, 4a, 4b), and 10 known lignans (5–14) were isolated from the fruit of Schisandra glaucescens Diels. The absolute configurations of 1 and 2 were determined by comparing their experimental and calculated electronic circular dichroism spectra. The molecular structures of the new compounds (3, 4a, and 4b), including their absolute config ...
- DOI:
- 10.1021/np4010536
- https://doi.org/10.1021/np4010536
- « Previous
- Next »
- 1
- 2
- 3
- 4