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1. 24-h Nitrogen dioxide concentration is associated with cooking behaviors and an increase in rescue medication use in children with asthma

Author:
Laura M. Paulin; D.’Ann L. Williams; Roger Peng; Gregory B. Diette; Meredith C. McCormack; Patrick Breysse; Nadia N. Hansel
Source:
Environmental research 2017 v.159 pp. 118-123
ISSN:
0013-9351
Subject:
asthma; byproducts; children; combustion; cooking; drug therapy; education; furnaces; heaters; longitudinal studies; lung function; morbidity; multivariate analysis; nitrogen dioxide; ovens
Abstract:
... Exposure to nitrogen dioxide (NO2), a byproduct of combustion, is associated with poor asthma control in children. We sought to determine whether gas-fueled kitchen appliance use is associated with 24-h indoor NO2 concentrations and whether these concentrations are associated with asthma morbidity in children. Children aged 5–12 years old with asthma were eligible. Mean 24-h NO2 concentration was ...
DOI:
10.1016/j.envres.2017.07.052
PubMed:
28797886
PubMed Central:
PMC5623630

2. 25-Hydroxvitamin D concentrations are not lower in children with bronchial asthma, atopic dermatitis, obesity, or attention-deficient/hyperactivity disorder than in healthy children

Author:
Thomas Reinehr; Christian Langrock; Eckard Hamelmann; Thomas Lücke; Cordula Koerner-Rettberg; Martin Holtmann; Tanja Legenbauer; Stephanie Gest; Mirjam Frank; Börge Schmidt; Katharina Radkowski; Karl-Heinz Jöckel
Source:
Nutrition research 2018 v.52 pp. 39-47
ISSN:
0271-5317
Subject:
adipose tissue; asthma; atopic dermatitis; blood sampling; body mass index; bone metabolism; boys; brain; children; lungs; obesity; parathyroid hormone; pathogenesis; questionnaires; receptors; regression analysis; standard deviation; vitamin D
Abstract:
... Vitamin D (vitD) is involved in immune regulation, and its receptor has been identified in several tissues including lung, adipose tissue, brain, and skin. Based on these observations, it has been suggested that vitD has an essential role not only in bone metabolism but also in other diseases such as atopic dermatitis (AD), bronchial asthma (BA), attention-deficit/hyperactivity disorder (ADHD), an ...
DOI:
10.1016/j.nutres.2018.01.002

3. 25-Hydroxyvitamin D concentrations, asthma and eczema in childhood: The generation R study

Author:
Ilse I.M. Tromp; Oscar H. Franco; Edith H. van den Hooven; Annemieke C. Heijboer; Vincent W.V. Jaddoe; Liesbeth Duijts; Johan C. de Jongste; Henriëtte A. Moll; Jessica C. Kiefte-de Jong
Source:
Clinical nutrition 2018 v.37 no.1 pp. 169-176
ISSN:
0261-5614
Subject:
asthma; blood serum; childhood; children; cohort studies; eczema; inflammation; nitric oxide; risk; risk reduction; vitamin D
Abstract:
... A role of vitamin D in the development of respiratory and allergic disease in children remains unclear. It may be likely that vitamin D has an effect on airway inflammation, but only few studies examined the effect in children. We aimed to examine whether serum 25-hydroxyvitamin D (25(OH) vitamin D) concentrations are associated with the fraction of exhaled nitric oxide (FeNO), airway interrupter ...
DOI:
10.1016/j.clnu.2016.11.019

4. A Medical Nutrition Therapy Primer for Childhood Asthma: Current and Emerging Perspectives

Author:
McCloud, Emily; Papoutsakis, Constantina
Source:
Journal of the American Dietetic Association 2011 v.111 no.7 pp. 1052-1064
ISSN:
0002-8223
Subject:
foods; drug therapy; bronchodilators; gastroesophageal reflux; chest; adrenal cortex hormones; eating habits; mouth; risk factors; disease control; children; chronic diseases; asthma; nutrition assessment; childhood obesity; childhood; food allergies; weight control; cough; healthy diet; Mediterranean diet; diet therapy; United States
Abstract:
... Asthma is the most common chronic disease in children. Prevalence has increased in the past 2 decades and has reached a plateau of approximately 9% of children in the United States, affecting about 6.7 million children. The increased prevalence of childhood asthma has paralleled the increased prevalence in childhood obesity. Changes in diet have also been implicated in the increased prevalence of ...
DOI:
10.1016/j.jada.2011.04.005
PubMed:
21703384

5. A US postmarketing evaluation of the frequency and safety of live attenuated influenza vaccine use in nonrecommended children younger than 5 years: 2009–2010 season

Author:
Patricia Tennis; Seth L. Toback; Elizabeth B. Andrews; Lisa J. McQuay; Christopher S. Ambrose
Source:
Vaccine 2012 v.30 no.42 pp. 6099-6102
ISSN:
0264-410X
Subject:
asthma; children; immunocompetence; influenza; risk; vaccination; vaccines; United States
Abstract:
... The 2007 US approval for use of Ann Arbor strain live attenuated influenza vaccine (LAIV) in children aged 24 through 59 months included precautions against use in (1) children <24 months and children aged 24 through 59 months with (2) asthma, (3) recurrent wheezing, and (4) altered immunocompetence. Results from the third season (2009–2010) of a 3-year study postmarketing commitment to monitor LA ...
DOI:
10.1016/j.vaccine.2012.07.031

6. A combined cohort analysis of prenatal exposure to phthalate mixtures and childhood asthma

Author:
Margaret A. Adgent; Kecia N. Carroll; Marnie F. Hazlehurst; Christine T. Loftus; Adam A. Szpiro; Catherine J. Karr; Emily S. Barrett; Kaja Z. LeWinn; Nicole R. Bush; Frances A. Tylavsky; Kurunthachalam Kannan; Sheela Sathyanarayana
Source:
Environment international 2020 v.143 pp. 105970
ISSN:
0160-4120
Subject:
asthma; childhood; children; confidence interval; drug therapy; environment; maternal exposure; metabolites; odds ratio; phthalates; regression analysis; urine
Abstract:
... Previous studies of prenatal phthalate exposure and childhood asthma are inconsistent. These studies typically model phthalates as individual, rather than co-occurring, exposures. We investigated whether prenatal phthalates are associated with childhood wheeze and asthma using a mixtures approach.We studied dyads from two prenatal cohorts in the ECHO-PATHWAYS consortium: CANDLE, recruited 2006–201 ...
DOI:
10.1016/j.envint.2020.105970

7. A multi-site feasibility study to assess fever and wheezing in children after influenza vaccines using text messaging

Author:
Melissa S. Stockwell; Colin D. Marchant; A. Patrica Wodi; Elizabeth D. Barnett; Karen R. Broder; Kathleen Jakob; Paige Lewis; Meyer Kattan; Anne Marie Rezendes; Angela Barrett; Devindra Sharma; Nadira Fernandez; Philip LaRussa
Source:
Vaccine 2017 v.35 no.50 pp. 6941-6948
ISSN:
0264-410X
Subject:
asthma; chest; children; confidence interval; cough; feasibility studies; fever; influenza; influenza vaccines; monitoring; pandemic; parents; vaccination; Massachusetts; New York
Abstract:
... Using text messaging for vaccine safety monitoring, particularly for non-medically attended events, would be valuable for pandemic influenza and emergency vaccination program preparedness. We assessed the feasibility and acceptability of text messaging to evaluate fever and wheezing post-influenza vaccination in a prospective, observational, multi-site pediatric study.Children aged 2–11 years old, ...
DOI:
10.1016/j.vaccine.2017.10.073
PubMed:
29089191
PubMed Central:
PMC6693331

8. A multistrain probiotic formulation attenuates skin symptoms of atopic dermatitis in a mouse model through the generation of CD4⁺Foxp3⁺ T cells

Author:
Joo-Hyun Shin; Myung-Jun Chung; Jae-Gu Seo
Source:
Food & nutrition research 2016 v.60 no.1 pp. 32550
ISSN:
1654-661X
Subject:
Bifidobacterium; CD4-positive T-lymphocytes; animal models; asthma; atopic dermatitis; blood serum; children; cytokines; genes; hosts; humans; immunoglobulin E; infants; inflammation; intestines; lactic acid bacteria; mice; probiotics; rhinitis; skin lesions; therapeutics
Abstract:
... Atopic dermatitis (AD) is characterized by chronic inflammation of the skin. AD develops mainly in infants and young children. It induces skin disorders and signals the initiation of the allergic march including allergic asthma and rhinitis. Probiotics modify intestinal microbial populations in a beneficial way for human and animal hosts by reducing inflammatory cytokines. As a result of their imm ...
DOI:
10.3402/fnr.v60.32550

9. A national burden assessment of estimated pediatric asthma emergency department visits that may be attributed to elevated ozone levels associated with the presence of smoke

Author:
Jacob R. Pratt; Ryan W. Gan; Bonne Ford; Steven Brey; Jeffrey R. Pierce; Emily V. Fischer; Sheryl Magzamen
Source:
Environmental monitoring and assessment 2019 v.191 no.Supplement 2 pp. 269
ISSN:
0167-6369
Subject:
asthma; children; nitrogen oxides; oxidation; ozone; pollutants; smoke; volatile organic compounds; wildfires; United States
Abstract:
... Asthma is the most common pediatric disease in the USA. It has been consistently demonstrated that asthma symptoms are exacerbated by exposure to ozone. Ozone (O₃) is a secondary pollutant produced when volatile organic compounds (VOCs) are oxidized in the atmosphere in the presence of nitrogen oxides (NOₓ). At ground level, elevated ozone is typically formed as a result of human activities. Howev ...
DOI:
10.1007/s10661-019-7420-5

10. A pilot randomised controlled trial investigating a Mediterranean diet intervention in pregnant women for the primary prevention of allergic diseases in infants

Author:
D. A. Sewell; V. S. Hammersley; A. Robertson; G. Devereux; A. Stoddart; C. J. Weir; A. Worth; A. Sheikh
Source:
Journal of human nutrition and dietetics 2017 v.30 no.5 pp. 604-614
ISSN:
0952-3871
Subject:
Mediterranean diet; asthma; children; confidence interval; infants; nutritional intervention; observational studies; pregnancy; pregnant women; protective effect; United Kingdom
Abstract:
... BACKGROUND: Observational studies suggest a potentially protective role of the Mediterranean diet (MD) in allergic diseases, including asthma. Large scale randomised controlled trials (RCTs) are needed to test the hypothesised allergy‐prevention benefits of a MD during pregnancy. The present two‐arm pilot RCT in pregnant women at high‐risk of having a child who would develop allergic disease inves ...
DOI:
10.1111/jhn.12469

11. A population-based birth cohort study of the association between childhood-onset asthma and exposure to industrial air pollutant emissions

Author:
Stéphane Buteau; Mariève Doucet; Louis-François Tétreault; Philippe Gamache; Michel Fournier; Allan Brand; Tom Kosatsky; Audrey Smargiassi
Source:
Environment international 2018 v.121 pp. 23-30
ISSN:
0160-4120
Subject:
air pollution; asthma; children; cohort studies; databases; emissions; gender; industry; models; particulates; regression analysis; risk; second hand smoke; sulfur dioxide; Quebec
Abstract:
... Studies of the association between air pollution and asthma onset have mostly focused on urban and traffic-related air pollution. We investigated the associations between exposure to industrial emissions and childhood-onset asthma in a population-based birth cohort in Quebec, Canada, 2002–2011.The cohort was built from administrative health databases. We developed separately for PM2.5 and SO2 diff ...
DOI:
10.1016/j.envint.2018.08.040

12. A postlicensure evaluation of the safety of Ann Arbor strain live attenuated influenza vaccine in children 24–59 months of age

Author:
Seth L. Toback; Christopher S. Ambrose; Abigail Eaton; John Hansen; Laurie Aukes; Ned Lewis; Xionghua Wu; Roger Baxter
Source:
Vaccine 2013 v.31 no.14 pp. 1812-1818
ISSN:
0264-410X
Subject:
anaphylaxis; asthma; children; clinical trials; influenza; vaccination; vaccines; United States
Abstract:
... In the United States, live attenuated influenza vaccine (LAIV) was initially approved for use in individuals aged 5–49 years in 2003, which was extended to individuals aged 2–49 years in 2007. At that time, a postlicensure commitment was made to describe the safety of LAIV within a cohort of eligible children aged 2–5 years.A prospective observational postmarketing study was conducted to evaluate ...
DOI:
10.1016/j.vaccine.2013.01.055

13. A postmarketing evaluation of the frequency of use and safety of live attenuated influenza vaccine use in nonrecommended children younger than 5 years

Author:
Patricia Tennis; Seth L. Toback; Elizabeth Andrews; Lisa J. McQuay; Christopher S. Ambrose
Source:
Vaccine 2011 v.29 no.31 pp. 4947-4952
ISSN:
0264-410X
Subject:
asthma; children; databases; guidelines; health insurance; immunocompetence; influenza; vaccination; vaccines; United States
Abstract:
... The 2007 US approval for use of live attenuated influenza vaccine (LAIV) in children aged 24–59 months included precautions against use in (1) children <24 months and children aged 24–59 months with (2) asthma, (3) recurrent wheezing, and (4) altered immunocompetence. A postmarketing commitment was initiated to monitor LAIV use and the frequency of select safety outcomes in these cohorts. Vaccinat ...
DOI:
10.1016/j.vaccine.2011.04.113

14. A postmarketing evaluation of the safety of Ann Arbor strain live attenuated influenza vaccine in children 5 through 17 years of age

Author:
Roger Baxter; Seth L. Toback; Frangiscos Sifakis; John Hansen; Joan Bartlett; Laurie Aukes; Ned Lewis; Xionghua Wu; Christopher S. Ambrose
Source:
Vaccine 2012 v.30 no.19 pp. 2989-2998
ISSN:
0264-410X
Subject:
anaphylaxis; asthma; children; clinical trials; influenza; vaccines; United States
Abstract:
... BACKGROUND: Live attenuated influenza vaccine (LAIV) was licensed in 2003 in the United States for use in individuals aged 5–49 years. METHODS: A prospective observational postmarketing study was conducted to evaluate the safety of LAIV. Rates of medically attended events (MAEs) and serious adverse events (SAEs) in eligible children aged 5–17 years receiving LAIV as part of routine care from Octob ...
DOI:
10.1016/j.vaccine.2012.02.039

15. A spatial-temporal regression model to predict daily outdoor residential PAH concentrations in an epidemiologic study in Fresno, CA

Author:
Elizabeth M. Noth; S. Katharine Hammond; Gregory S. Biging; Ira B. Tager
Source:
Atmospheric environment 2011 v.45 no.14 pp. 2394-2403
ISSN:
1352-2310
Subject:
air pollution; asthma; atmospheric chemistry; children; combustion; epidemiological studies; fuels; heat; land use; landforms; meteorological data; models; polycyclic aromatic hydrocarbons; regression analysis; risk; traffic; California
Abstract:
... BACKGROUND: Polycyclic aromatic hydrocarbons (PAHs) are generated as a byproduct of combustion, and are associated with respiratory symptoms and increased risk of asthma attacks. OBJECTIVES: To assign daily, outdoor exposures to participants in the Fresno Asthmatic Children’s Environment Study (FACES) using land use regression models for the sum of 4-, 5- and 6-ring PAHs (PAH456). METHODS: PAH dat ...
DOI:
10.1016/j.atmosenv.2011.02.014

16. Acute Care Costs in Overweight Children: A Pediatric Urban Cohort Study

Author:
Fleming-Dutra Katherine E.; Mao Jingnan; Leonard Julie C.
Source:
Childhood obesity 2013 v.9 no.4 pp. 338-345
ISSN:
2153-2176
Subject:
asthma; childhood obesity; children; cohort studies; health care costs; models; obesity-related diseases; patients; regression analysis; urban areas
Abstract:
... Background: Evidence indicates obese children have increased health care utilization. It is unknown if this is true within the emergency department (ED) setting. Our purpose is to determine if overweight children presenting for emergency care have increased resource utilization over normal weight peers.Methods: We conducted a retrospective cohort study of children 2 to <18 years old presenting to ...
DOI:
10.1089/chi.2012.0134

17. Acute effects of air pollution on pediatric asthma exacerbation: Evidence of association and effect modification

Author:
E. Samoli; P.T. Nastos; A.G. Paliatsos; K. Katsouyanni; K.N. Priftis
Source:
Environmental research 2011 v.111 no.3 pp. 418-424
ISSN:
0013-9351
Subject:
acute effects; air pollution; asthma; children; confidence interval; hospitals; influenza; monitoring; nitrogen dioxide; ozone; particulates; regression analysis; spring; sulfur dioxide; summer; weather; winter; Greece
Abstract:
... We investigated the short-term effects of particulate matter with aerodynamic diameter <10μg/m³ (PM₁₀), sulfur dioxide (SO₂), nitrogen dioxide (NO₂) and ozone (O₃) on pediatric asthma emergency admissions in Athens, Greece over the period 2001–2004. We explored effect modification patterns by season, sex, age and by the presence of desert dust transported mainly from the Sahara area. We used daily ...
DOI:
10.1016/j.envres.2011.01.014

18. Acute effects of ambient air pollution on lower respiratory infections in Hanoi children: An eight-year time series study

Author:
Nguyen Thi Trang Nhung; Christian Schindler; Tran Minh Dien; Nicole Probst-Hensch; Laura Perez; Nino Künzli
Source:
Environment international 2017 pp. -
ISSN:
0160-4120
Subject:
acute effects; air; air pollutants; air pollution; asthma; bronchitis; children; databases; developing countries; disease outbreaks; gender; hospitals; infants; influenza; issues and policy; meteorological parameters; models; nitrogen dioxide; ozone; pneumonia; regression analysis; seasonal variation; sulfur dioxide; time series analysis; Vietnam
Abstract:
... Lower respiratory diseases are the most frequent causes of hospital admission in children worldwide, particularly in developing countries. Daily levels of air pollution are associated with lower respiratory diseases, as documented in many time–series studies. However, investigations in low-and-middle-income countries, such as Vietnam, remain sparse.This study investigated the short-term associatio ...
DOI:
10.1016/j.envint.2017.10.024

19. Acute effects of black carbon and PM2.5 on children asthma admissions: A time-series study in a Chinese city

Author:
Jing Hua; Yong Yin; Li Peng; Li Du; Fuhai Geng; Liping Zhu
Source:
Science of the total environment 2014 v.481 pp. 433-438
ISSN:
0048-9697
Subject:
acute effects; air; air quality; asthma; carbon; childhood; children; dose response; models; nitrogen dioxide; sulfur dioxide; time series analysis; China
Abstract:
... Epidemiologic evidence for an association between black carbon (BC) and health outcomes is limited. We estimated associations and exposure–response relationships between childhood asthma admission and concentration of BC and PM2.5 (particle less than 2.5mm in aerodynamic diameter) in ambient air in Shanghai using a lag distributed model. The PM2.5 and the BC were significantly associated with chil ...
DOI:
10.1016/j.scitotenv.2014.02.070

20. Adenylyl cyclase type 9 gene polymorphisms are associated with asthma and allergy in Brazilian children

Author:
Helena M.P. Teixeira; Neuza M. Alcantara-Neves; Maurício Barreto; Camila A. Figueiredo; Ryan S. Costa
Source:
Molecular immunology 2017 v.82 pp. 137-145
ISSN:
0161-5890
Subject:
immunomodulation; ancestry; cyclic AMP; genes; computer software; second messengers; phenotype; cytokines; respiratory system; adenylate cyclase; genotyping; skin prick tests; helminthiasis; humans; children; immunoglobulin E; asthma; immune response; single nucleotide polymorphism; social change; regression analysis; environmental factors; genetic variation; Latin America; Brazil
Abstract:
... Asthma is a chronic inflammatory disease of the respiratory tract. This heterogeneous disease is caused by the interaction of interindividual genetic variability and environmental factors. The gene adenylyl cyclase type 9 (ADCY9) encodes a protein called adenylyl cyclase (AC), responsible for producing the second messenger cyclic AMP (cAMP). cAMP is produced by T regulatory cells and is involved i ...
DOI:
10.1016/j.molimm.2017.01.001

21. Admixture of beneficial and unfavourable variants of GLCCI1 and FCER2 in Roma samples can implicate different clinical response to corticosteroids

Author:
Renata Szalai; Petra Matyas; Dalma Varszegi; Marton Melegh; Lili Magyari; Luca Jaromi; Katalin Sumegi; Balazs Duga; Erzsebet Kovesdi; Kinga Hadzsiev; Bela Melegh
Source:
Molecular biology reports 2014 v.41 no.11 pp. 7665-7669
ISSN:
0301-4851
Subject:
adrenal cortex hormones; alleles; asthma; children; ethnic differences; gene frequency; homozygosity; immunoglobulin E; linkage disequilibrium; polymerase chain reaction; single nucleotide polymorphism
Abstract:
... Variants of glucocorticoid induced transcript 1 (GLCCI1) result decreased response to inhaled corticosteroids, while intronic variant of low-affinity IgE receptor (FCER2) is associated with exacerbation rates in children with asthma. We examined the ethnic differences, allele and genotype frequencies of two linked single nucleotide polymorphisms (rs37972, rs37973) of GLCCI1 and rs28364072 intronic ...
DOI:
10.1007/s11033-014-3659-7
PubMed:
25091946

22. Adverse health effects of ferronickel manufacturing factory on local residents: An interrupted time series analysis

Author:
Changwoo Han; Yun-Chul Hong
Source:
Environment international 2018 v.114 pp. 288-296
ISSN:
0160-4120
Subject:
adverse effects; asthma; children; cities; databases; dermatitis; disease incidence; dust; ferrous alloys; heavy metals; hospitals; iron; manufacturing; men; nickel; pruritus; regression analysis; rhinitis; risk estimate; slags; time series analysis; women; South Korea
Abstract:
... The first ferronickel manufacturing factory of the Republic of Korea was opened in Gwangyang City on October, 23rd, 2008. There has been public concern regarding heavy metal dust blown from the factory and slag disposal site. Therefore, we evaluated the health impact of the ferronickel factory on Gwangyang City residents by using interrupted time series analysis. We analyzed the monthly incidence ...
DOI:
10.1016/j.envint.2018.02.045

23. Aeroallergen sensitization in Lebanese asthmatic children: the results of a cohort national study

Author:
Hala Feghali Abiad; Valeria Modica Alameddine; Souheil Hallit; Paul-Henry Torbey; Salman Mroueh; Nelly Yazbek; Edgard Asmar; Pierre Hage; George Abi Fares; Marie Samarani; Marie-Claude Fadous Khalife
Source:
Environmental science and pollution research international 2020 v.27 no.5 pp. 5597-5605
ISSN:
0944-1344
Subject:
Alternaria; Anthoxanthum odoratum; Aspergillus fumigatus; Blattella germanica; Cupressaceae; Dactylis glomerata; Dermatophagoides pteronyssinus; Lolium; Parietaria; allergens; altitude; asthma; barley; childhood; children; corn; dogs; dust mites; grasses; meadows; national surveys; oats; olives; patients; prognosis; skin prick tests; wheat; Lebanon
Abstract:
... Atopic asthma is characterized by the presence of sensitization to common aeroallergens, which tends to have a worse prognosis than non-atopic asthma. The objectives were to determine the prevalence of aeroallergens sensitization in the Lebanese pediatric asthmatic population and determine the relationship between allergens sensitization (indoor and outdoor) and age, area of residence and altitude ...
DOI:
10.1007/s11356-019-07234-z

24. Air pollution and asthma attacks in children: A case–crossover analysis in the city of Chongqing, China

Author:
Ling Ding; Daojuan Zhu; Donghong Peng; Yao Zhao
Source:
Environmental pollution 2017 v.220 pp. 348-353
ISSN:
0269-7491
Subject:
acute exposure; air; air pollution; asthma; carbon monoxide; children; hospitals; nitrogen; nitrogen dioxide; ozone; particulates; pollutants; regression analysis; sodium; China
Abstract:
... Data on particulate matter of diameter <2.5 μm (PM2.5) in the city of Chongqing were first announced in 2013. We wished to assess the effects of pollutants on asthmatic children in Chongqing, China. Daily numbers of hospital visits because of asthma attacks in children aged 0–18 years in 2013 were collected from the Children's Hospital of Chongqing Medical University. Data on pollutants were acces ...
DOI:
10.1016/j.envpol.2016.09.070

25. Air pollution and childhood bronchitis: Interaction with xenobiotic, immune regulatory and DNA repair genes

Author:
Rakesh Ghosh; Pavel Rossner; Katerina Honkova; Miroslav Dostal; Radim J. Sram; Irva Hertz-Picciotto
Source:
Environment international 2016 v.87 pp. 94-100
ISSN:
0160-4120
Subject:
DNA repair; acute course; air; air pollution; alleles; asthma; bronchitis; childhood; children; equations; genotype-environment interaction; genotyping; interleukin-10; medical records; neoplasms; particulates; pathogenesis; pollutants; polycyclic aromatic hydrocarbons; regression analysis; single nucleotide polymorphism; xenobiotics
Abstract:
... Gene–environment interactions have been investigated for diseases such as asthma, chronic obstructive pulmonary disease, cancer etc. but acute disease like bronchitis has rarely been studied. We investigated interactions between air pollution (polycyclic aromatic hydrocarbons (PAH) and particulate matter <2.5μm (PM2.5)) and single nucleotide polymorphisms (SNP) in EPHX1, IL10, STAT4 and XPC genes ...
DOI:
10.1016/j.envint.2015.10.002

26. Air pollution and cytokine responsiveness in asthmatic and non-asthmatic children

Author:
Claudia Klümper; Ursula Krämer; Irina Lehmann; Andrea von Berg; Dietrich Berdel; Gunda Herberth; Christina Beckmann; Elke Link; Joachim Heinrich; Barbara Hoffmann; Roel P.F. Schins
Source:
Environmental Research 2015 v.138 pp. 381-390
ISSN:
0013-9351
Subject:
interferon-gamma; cohort studies; land use; inflammation; interleukin-6; regression analysis; confidence interval; tumor necrosis factor-alpha; children; chemokine CCL2; asthma; interleukin-10; nitrogen dioxide; air pollution; particulates; blood; oxidative stress; interleukin-8
Abstract:
... Epidemiological studies indicate that asthmatic children are more susceptible to traffic-related air pollution exposure than non-asthmatic children. Local and systemic inflammation in combination with oxidative stress have been suggested as a possible susceptibility factor.We investigated effect modification by asthma status for the association between air pollution exposure and systemic effects u ...
DOI:
10.1016/j.envres.2015.02.034

27. Air pollution and health impacts during the COVID-19 lockdowns in Grenoble, France

Author:
Marie-Laure Aix; Pascal Petit; Dominique J. Bicout
Source:
Environmental pollution 2022 v.303 pp. 119134
ISSN:
0269-7491
Subject:
COVID-19 infection; air; air pollution; air quality; asthma; children; human health; low birth weight; lung neoplasms; mortality; public health; traffic; France
Abstract:
... It is undeniable that exposure to outdoor air pollution impacts the health of populations and therefore constitutes a public health problem. Any actions or events causing variations in air quality have repercussions on populations’ health. Faced with the worldwide COVID-19 health crisis that began at the end of 2019, the governments of several countries were forced, in the beginning of 2020, to pu ...
DOI:
10.1016/j.envpol.2022.119134

28. Air pollution and respiratory hospital admissions in Shiraz, Iran, 2009 to 2015

Author:
Zahra Soleimani; Ali Darvishi Boloorani; Reza Khalifeh; Pari Teymouri; Alireza Mesdaghinia; Dale W. Griffin
Source:
Atmospheric environment 2019 v.209 pp. 233-239
ISSN:
1352-2310
Subject:
acute exposure; air pollutants; air pollution; asthma; atmospheric chemistry; carbon monoxide; children; cities; demographic statistics; hospitals; linear models; nitrogen dioxide; ozone; particulates; patients; pneumonia; principal component analysis; relative humidity; relative risk; sulfur dioxide; temperature; urban areas; Iran
Abstract:
... Air pollution has been identified as one of the most challenging health issues in urban areas worldwide.The aim of this study was to investigate the association between short-term exposure to ambient air pollution and respiratory disease over a long-term period in Shiraz, one of the largest cities in Iran. Methods: hospital admissions due to respiratory diseases (asthma, pneumonia, chronic obstruc ...
DOI:
10.1016/j.atmosenv.2019.04.030

29. Air pollution and respiratory symptoms among children with asthma: Vulnerability by corticosteroid use and residence area

Author:
Toby C. Lewis; Thomas G. Robins; Graciela B. Mentz; Xiaohui Zhang; Bhramar Mukherjee; Xihong Lin; Gerald J. Keeler; J. Timothy Dvonch; Fuyuen Y. Yip; Marie S. O'Neill; Edith A. Parker; Barbara A. Israel; Paul T. Max; Angela Reyes
Source:
Science of the total environment 2013 v.448 pp. 48-55
ISSN:
0048-9697
Subject:
African Americans; Latinos; air pollution; air quality; asthma; at-risk population; children; cities; drug therapy; equations; exposure assessment; logit analysis; models; ozone; particulates; pollutants; prospective studies; risk reduction; steroids; Michigan
Abstract:
... Information on how ambient air pollution affects susceptible populations is needed to ensure protective air quality standards.To estimate the effect of community-level ambient particulate matter (PM) and ozone (O3) on respiratory symptoms among primarily African-American and Latino, lower-income asthmatic children living in Detroit, Michigan and to evaluate factors associated with heterogeneity in ...
DOI:
10.1016/j.scitotenv.2012.11.070
PubMed:
23273373
PubMed Central:
PMC4327853

30. Air pollution from industries and asthma onset in childhood: A population-based birth cohort study using dispersion modeling

Author:
Stéphane Buteau; Maryam Shekarrizfard; Marianne Hatzopolou; Philippe Gamache; Ling Liu; Audrey Smargiassi
Source:
Environmental research 2020 v.185 pp. 109180
ISSN:
0013-9351
Subject:
air pollutants; air pollution; algorithms; asthma; childhood; children; cohort studies; databases; emissions; industry; models; nitrogen dioxide; particulates; risk; sulfur dioxide; Quebec
Abstract:
... Despite evidence that ambient air pollution may play a role in the development of asthma, little is known about the potential contribution of industrial emissions.We used a population-based birth cohort to investigate the association between asthma onset in childhood and residential exposure to industrial emissions, estimated from atmospheric dispersion modeling.The study population comprised all ...
DOI:
10.1016/j.envres.2020.109180

31. Air quality trends and potential health effects – Development of an aggregate risk index

Author:
Pierre Sicard; Olivia Lesne; Nicolas Alexandre; Antoine Mangin; Rémy Collomp
Source:
Atmospheric environment 2011 v.45 no.5 pp. 1145-1153
ISSN:
1352-2310
Subject:
Mediterranean climate; additive effect; adverse effects; air; air pollution; air quality; asthma; atmospheric chemistry; cerebrovascular disorders; children; data collection; emissions; health hazards; heart diseases; models; morbidity; mortality; nitrogen dioxide; ozone; pollutants; prediction; public health; relative risk; sulfur dioxide; traffic; warm season; France
Abstract:
... The “Provence Alpes Côte d’Azur” (PACA) region, in the South East of France, is one of Europe’s regions most influenced by the atmospheric pollution. During the last 15 years, the industrial emissions decrease caused an evolution of the atmospheric pollution nature. Nowadays, atmospheric pollution is more and more influenced by the road traffic, the dominating pollution source in urban zones for t ...
DOI:
10.1016/j.atmosenv.2010.12.052

32. Allelic polymorphism C-590T of the IL4 gene as a probable genetic marker for the increased predisposition to the development of recurrent episodes of acute obstructive bronchitis in children

Author:
O. V. Kens; N. V. Vishtak; H. R. Acopyan; V. I. Bergtravm
Source:
Cytology and genetics 2016 v.50 no.3 pp. 173-177
ISSN:
0095-4527
Subject:
asthma; blood serum; bronchitis; children; genes; genetic markers; genotype; immunoglobulin E; interleukin-4; loci; risk
Abstract:
... Acute respiratory infections (ARIs) hold the first place among all infections throughout the world. ARIs are frequently complicated by the development of acute obstructive bronchitis (AOB). According to different authors, the frequency of developing AOB due to ARIs in children ranges from 5 to 40%. The growing occurrences of ARIs in children and the formation of bronchoobstructive syndrome that fr ...
DOI:
10.3103/S0095452716030051

33. Allergen-specific immunotherapy, novel drugs and biologicals: hopes from the difficult-to-treat allergic child

Author:
Carla Mastrorilli; Angelica Santoro; Carlo Caffarelli
Source:
Aerobiologia 2020 v.36 no.1 pp. 95-98
ISSN:
0393-5965
Subject:
allergens; asthma; atopic dermatitis; childhood; children; diagnostic techniques; drugs; immunotherapy; monoclonal antibodies; patients; phenotype; urticaria
Abstract:
... In the last decades, significant progresses have been reached in the management of atopic diseases in childhood. Several approaches have been proposed in patients affected by moderate-to-severe atopic diseases. Severe asthma and atopic dermatitis are poorly known with different underlying phenotypes and endotypes, and they may require further cares with biological therapies. Omalizumab, anti-IgE m ...
DOI:
10.1007/s10453-019-09573-3

34. Allergic asthma exhaled breath metabolome: A challenge for comprehensive two-dimensional gas chromatography

Author:
M. Caldeira; R. Perestrelo; A.S. Barros; M.J. Bilelo; A. Morête; J.S. Câmara; S.M. Rocha
Source:
Journal of chromatography 2012 v.1254 no. pp. 87-97
ISSN:
0021-9673
Subject:
asthma; biochemistry; children; comprehensive two-dimensional gas chromatography; decane; equipment; inflammation; lungs; mass spectrometry; metabolome; metabolomics; models; multivariate analysis; oxidative stress; rhinitis
Abstract:
... Allergic asthma represents an important public health issue, most common in the paediatric population, characterized by airway inflammation that may lead to changes in volatiles secreted via the lungs. Thus, exhaled breath has potential to be a matrix with relevant metabolomic information to characterize this disease. Progress in biochemistry, health sciences and related areas depends on instrumen ...
DOI:
10.1016/j.chroma.2012.07.023

35. Alt a 1 from Alternaria interacts with PR5 thaumatin-like proteins

Author:
Cristina Gómez-Casado; Amaya Murua-García; María Garrido-Arandia; Pablo González-Melendi; Rosa Sánchez-Monge; Domingo Barber; Luis F. Pacios; Araceli Díaz-Perales
Source:
FEBS letters 2014 v.588 no.9 pp. 1501-1508
ISSN:
0014-5793
Subject:
proteins; spores; food contamination; hyphae; human health; kiwifruit; children; asthma; Alternaria alternata; genes; patients; enzyme activity; gene expression regulation; virulence; pulp
Abstract:
... Alt a 1 is a protein found in Alternaria alternata spores related to virulence and pathogenicity and considered to be responsible for chronic asthma in children. We found that spores of Alternaria inoculated on the outer surface of kiwifruits did not develop hyphae. Nevertheless, the expression of Alt a 1 gene was upregulated, and the protein was detected in the pulp where it co-localized with kiw ...
DOI:
10.1016/j.febslet.2014.02.044

36. Altered vulnerability to asthma at various levels of ambient Benzo[a]Pyrene by CTLA4, STAT4 and CYP2E1 polymorphisms

Author:
Hyunok Choi; Nana Tabashidze; Pavel Rossner; Miroslav Dostal; Anna Pastorkova; Sek Won Kong; Hans Gmuender; Radim J. Sram
Source:
Environmental pollution 2017 v.231 pp. 1134-1144
ISSN:
0269-7491
Subject:
DNA; air; asthma; benzo(a)pyrene; carcinogens; children; genes; genotype; genotype-environment interaction; genotyping; models; monitoring; risk factors; screening; single nucleotide polymorphism; urban areas; Czech Republic
Abstract:
... Within fossil- and solid-fuel dependent geographic locations, mechanisms of air pollution-induced asthma remains unknown. In particular, sources of greater genetic susceptibility to airborne carcinogen, namely, benzo[a]pyrene (B[a]P) has never been investigated beyond that of a few well known genes.To deepen our understanding on how the genotypic variations within the candidate genes contribute to ...
DOI:
10.1016/j.envpol.2017.07.057

37. Ambient Air Pollution and Daily Pediatric Hospitalizations for Asthma (5 pp)

Author:
James Regens
Source:
Environmental science and pollution research international 2007 v.14 no.1 pp. 19-23
ISSN:
0944-1344
Subject:
adverse effects; air; air pollution; air quality; asthma; children; cities; environmental exposure; health services; hospitals; human health; mortality; nitrogen dioxide; pollutants; public health; regression analysis; relative risk; risk factors; scientists; smoking (habit); temperature; time series analysis; Europe; Oklahoma
Abstract:
... BACKGROUND, AIM AND SCOPE: A series of severe air pollution episodes in Europe and North America prior to 1960 have focused scientific and regulatory attention on the adverse effects of air pollution on human health. As a consequence of significant reductions in ambient air pollution levels in the intervening years, scientists and public health officials have become more concerned with the potenti ...
DOI:
10.1065/espr2006.08.333

38. Ambient air pollution and low birth weight - are some women more vulnerable than others?

Author:
Nadja Westergaard; Ulrike Gehring; Rémy Slama; Marie Pedersen
Source:
Environment international 2017 pp. -
ISSN:
0160-4120
Subject:
air; air pollution; asthma; body mass index; children; epidemiological studies; human health; infants; low birth weight; odds ratio; overweight; pregnancy; pregnant women; risk factors; socioeconomic status; underweight
Abstract:
... Ambient air pollution is controllable, and it is one of the greatest environmental threats to human health. Studies conducted worldwide have provided evidence that maternal exposure to ambient air pollution during pregnancy enhances the risk of low birth weight at term (TLBW, <2500g among infants born ≥37 completed weeks of gestation), a maker of intrauterine growth restriction (IUGR), and suggest ...
DOI:
10.1016/j.envint.2017.03.026

39. Ambient daily pollen levels in association with asthma exacerbation among children in Philadelphia, Pennsylvania

Author:
Anneclaire J. De Roos; Chén C. Kenyon; Yuzhe Zhao; Kari Moore; Steve Melly; Rebecca A. Hubbard; Sarah E. Henrickson; Christopher B. Forrest; Ana V. Diez Roux; Mitchell Maltenfort; Leah H. Schinasi
Source:
Environment international 2020 v.145 pp. 106138
ISSN:
0160-4120
Subject:
allergic rhinitis; asthma; children; environment; grasses; hospitals; human health; nationalities and ethnic groups; pollen; regression analysis; relative humidity; telemedicine; temperature; trees; vegetation; Pennsylvania
Abstract:
... Pollen from trees, grasses, and weeds can trigger asthma exacerbation in sensitized individuals. However, there are gaps in knowledge about the effects, such as the relative risks from different plant taxa and threshold levels of effect. We aimed to describe the local association between pollen and asthma exacerbation among children in the City of Philadelphia, and to evaluate whether effects are ...
DOI:
10.1016/j.envint.2020.106138

40. An evaluation of the air quality health index program on respiratory diseases in Hong Kong: An interrupted time series analysis

Author:
Tonya G. Mason; C. Mary Schooling; King Pan Chan; Linwei Tian
Source:
Atmospheric environment 2019 v.211 pp. 151-158
ISSN:
1352-2310
Subject:
air pollutants; air pollution; air quality; asthma; at-risk population; atmospheric chemistry; behavior change; children; confidence interval; hospitals; humidity; issues and policy; morbidity; nitrogen dioxide; ozone; particulates; pneumonia; relative risk; sulfur dioxide; temperature; time series analysis; China
Abstract:
... On December 30th, 2013, the Hong Kong government implemented the Air Quality Health Index (AQHI) alert programme warnings designed to reduce short-term effects of air pollution on population health. However, whether air quality alert programme warnings, such as the AQHI, reduce morbidity is still questionable. Using a quasi-experimental design, we conducted the first evaluation of the AQHI in Hong ...
DOI:
10.1016/j.atmosenv.2019.05.013

41. An exploratory study of the associations between maternal iron status in pregnancy and childhood wheeze and atopy

Author:
Bright I. Nwaru; Helen Hayes; Lorraine Gambling; Leone C. A. Craig; Keith Allan; Nanda Prabhu; Steven W. Turner; Geraldine McNeill; Maijaliisa Erkkola; Anthony Seaton; Harry J. McArdle; Graham Devereux
Source:
British journal of nutrition 2014 v.112 no.12 pp. 2018-2027
ISSN:
1475-2662
Subject:
asthma; atopy; blood serum; childhood; children; eczema; ferritin; iron; longitudinal studies; lung function; nutritional status; parents; pregnancy; risk; transferrin; ultrasonics; umbilical cord
Abstract:
... Maternal nutritional status during pregnancy has been reported to be associated with childhood asthma and atopic disease. The Avon Longitudinal Study of Parents and Children has reported associations between reduced umbilical cord Fe status and childhood wheeze and eczema; however, follow-up was short and lung function was not measured. In the present study, the associations between maternal Fe st ...
DOI:
10.1017/S0007114514003122
PubMed:
25342229

42. An obesity-preventive lifestyle score is negatively associated with pediatric asthma

Author:
Constantina Papoutsakis; Eleni Papadakou; Maria Chondronikola; Georgios Antonogeorgos; Vasiliki Matziou; Maria Drakouli; Evanthia Konstantaki; Kostas N. Priftis
Source:
European journal of nutrition 2018 v.57 no.4 pp. 1605-1613
ISSN:
1436-6207
Subject:
asthma; body mass index; case-control studies; childhood; children; food intake; lifestyle; medical history; obesity; pediatrics; physical activity; risk; waist circumference
Abstract:
... PURPOSE: Lifestyle (diet and physical activity) may increase asthma risk, but evidence in this area is lacking. The aims of the present study were to calculate an obesity-preventive lifestyle score comprising of eating and physical activity behaviors and investigate the overall effect of lifestyle on asthma in children. METHODS: A cross-sectional case–control study was carried out in 514 children ...
DOI:
10.1007/s00394-017-1446-7

43. Anthropogenic or non-anthropogenic particulate matter: Which one is more dangerous and how to differentiate between the effects?

Author:
Lena Novack; Yorye Shenkar; Alexandra Shtein; Itai Kloog; Batia Sarov; Victor Novack
Source:
Chemosphere 2020 v.240 pp. 124954
ISSN:
0045-6535
Subject:
anthropogenic activities; asthma; chemical composition; children; models; monitoring; nitrogen dioxide; particulates; pollutants
Abstract:
... The authors have observed that the function linking health outcomes with exposure to particulate-matter (PM) follows a biphasic pattern. It peaks around levels of PM10≤100 μg/m3, then weakens and rises again at PM10 levels in the range of hundreds. This could be due to a different nature of PM, the first peak reflecting a stronger anthropogenic and the second - weaker non-anthropogenic particles' ...
DOI:
10.1016/j.chemosphere.2019.124954

44. Apoptosis of Eosinophil Granulocytes

Author:
Martina Zustakova; Lucie Kratochvilova; Petr Slama
Source:
Biology 2020 v.9 no.12 pp. -
ISSN:
2079-7737
Subject:
adults; apoptosis; asthma; children; dermatitis; eosinophilia; eosinophils; food allergies; glucocorticoids; half life; infants; inflammation; knowledge; medicine; people; pollen; Czech Republic
Abstract:
... In the past 10 years, the number of people in the Czech Republic with allergies has doubled to over three million. Allergic pollen catarrh, constitutional dermatitis and asthma are the allergic disorders most often diagnosed. Genuine food allergies today affect 6–8% of nursing infants, 3–5% of small children, and 2–4% of adults. These disorders are connected with eosinophil granulocytes and their ...
DOI:
10.3390/biology9120457

45. Arachidonic acid intake and asthma risk in children and adults: a systematic review of observational studies

Author:
Saki Kakutani; Kahori Egawa; Kayo Saito; Toshihide Suzuki; Chika Horikawa; Tomohiro Rogi; Hiroshi Kawashima; Hiroshi Shibata; Satoshi Sasaki
Source:
Journal of nutritional science 2014 v.3 pp. -
ISSN:
2048-6790
Subject:
adults; arachidonic acid; asthma; blood; children; meta-analysis; observational studies; patients; risk; systematic review
Abstract:
... The effect of arachidonic acid (ARA) intake on asthma risk is unclear. The objective of the present review was to systematically evaluate available observational studies on the relationship between ARA exposure and asthma risk in children and adults. A PubMed search was conducted on 22 October 2013 and seventy-three publications were checked against predefined criteria for eligibility. To identify ...
DOI:
10.1017/jns.2014.9
PubMed:
25191604
PubMed Central:
PMC4153330

46. Assessment of Hymenoptera and Non-Hymenoptera Insect Bite and Sting Allergy Among Patients of Tropical Region of West Bengal, India

Author:
Arghya Laha; Tania Sarkar; Debarati Dey; Priti Mondal; Srijit Bhattacharya; Saibal Moitra; Goutam Kumar Saha; Sanjoy Podder; David Florin
Source:
Journal of medical entomology 2020 v.57 no.1 pp. 1-7
ISSN:
1938-2928
Subject:
Aedes aegypti; Apis cerana indica; Formica fusca; Lasius niger; Musca domestica; Periplaneta americana; Solenopsis invicta; Vespula vulgaris; adolescents; adults; allergens; asthma; bites and stings; children; farmers; females; fire ants; grasshoppers; humans; males; occupations; patients; skin prick tests; tropics; venoms; worker honey bees; India
Abstract:
... West Bengal, India, is inhabited by abundance and variety of insects that triggers sensitization in some humans to inhalant allergens and/or insect stings/venoms. Lack of research on this topic prevented accurate diagnosis and proper follow-up treatments to patients suffering from insect-induced allergies. The aim of our study was to identify the allergy-causing insects and evaluate resulting sens ...
DOI:
10.1093/jme/tjz088

47. Association Between CD14 Polymorphism (−1145G/A) and Childhood Bronchial Asthma

Author:
Enas Samir Nabih; Hala Fawzy M. Kamel; Terez Boshra Kamel
Source:
Biochemical genetics 2016 v.54 no.1 pp. 50-60
ISSN:
0006-2928
Subject:
alleles; asthma; atopy; blood serum; childhood; children; enzyme-linked immunosorbent assay; genotype; genotyping; immunoglobulin E; patients; promoter regions; quantitative polymerase chain reaction
Abstract:
... Polymorphisms in the promoter region of CD14 gene have been associated with asthma and atopy although the findings between cohorts have not been uniform. We aimed at investigating the association between CD14 gene (−1145G/A) polymorphism and bronchial asthma in Egyptian children. Genotyping of CD14 gene (−1145G/A) polymorphism was done by real-time PCR in 192 asthmatic children (atopic, n = 100 an ...
DOI:
10.1007/s10528-015-9699-4

48. Association between Breastfeeding and Childhood Obesity: Analysis of a Linked Longitudinal Study of Rural Appalachian Fifth-Grade Children

Author:
Umer Amna; Hamilton Candice; Britton Cris M.; Mullett Martha D.; John Collin; Neal William; Lilly Christa L.
Source:
Childhood obesity 2015 v.11 no.4 pp. 449-455
ISSN:
2153-2176
Subject:
Department of Health and Human Services; adolescence; asthma; birth weight; body mass index; breast feeding; childhood; childhood obesity; children; data collection; diabetes; education; health insurance; hypercholesterolemia; longitudinal studies; regression analysis; Appalachian region; West Virginia
Abstract:
... Introduction: Although breastfeeding is associated with improving numerous health outcomes for the child, its role in reducing childhood obesity is contested. Despite this controversy, both the CDC and the US Department of Health and Human Services promote breastfeeding as one of the strategies for reducing childhood obesity. Rural Appalachia has one of the highest rates of childhood obesity and l ...
DOI:
10.1089/chi.2015.0026

49. Association between Frequency of Consumption of Fruit, Vegetables, Nuts and Pulses and BMI: Analyses of the International Study of Asthma and Allergies in Childhood (ISAAC)

Author:
Clare R. Wall; Alistair W. Stewart; Robert J. Hancox; Rinki Murphy; Irene Braithwaite; Richard Beasley; Edwin A. Mitchell; The ISAAC Phase Three Study Group
Source:
Nutrients 2018 v.10 no.3 pp. -
ISSN:
2072-6643
Subject:
vegetables; linear models; fruits; parents; ideal body weight; children; asthma; fruit consumption; adolescents; food frequency questionnaires; nuts; childhood; body mass index; plant-based foods; vegetable consumption; dietary recommendations
Abstract:
... Diets which emphasize intakes of plant-based foods are recommended to reduce disease risk and for promoting healthy weight. The aim of this study was to examine the association between fruit, vegetables, pulses and nut intake and body mass index (BMI) across countries in adolescents (13–14 years) and children (6–7 years). Data from the International Study of Asthma and Allergies in Childhood; 77,2 ...
DOI:
10.3390/nu10030316
PubMed:
29518923
PubMed Central:
PMC5872734

50. Association between prenatal metal exposure and adverse respiratory symptoms in childhood

Author:
Nia McRae; Chris Gennings; Nadya Rivera Rivera; Marcela Tamayo-Ortiz; Ivan Pantic; Chitra Amarasiriwardena; Lourdes Schnaas; Rosalind Wright; Martha M. Tellez-Rojo; Robert O. Wright; Maria José Rosa
Source:
Environmental research 2022 v.205 pp. 112448
ISSN:
0013-9351
Subject:
asthma; blood; childhood; children; education; lead; manganese; maternal exposure; obesity; odds ratio; research; second hand smoke; statistical models; surveys; Mexico
Abstract:
... Manganese and lead have been cross-sectionally associated with adverse respiratory outcomes in childhood but there is limited data on their combined effects starting in utero. We examined associations between in utero exposure to metals and childhood respiratory symptoms. We assessed 633 mother-child dyads enrolled in the Programming Research in Obesity, Growth, Environment, and Social Stressors ( ...
DOI:
10.1016/j.envres.2021.112448

51. Association between β+252 tumour necrosis factor polymorphism and asthma in western Saudi children

Author:
Essam H. Jiffri; Nasser A. Elhawary
Source:
Saudi journal of biological sciences 2011 v.18 no.1 pp. 107-111
ISSN:
1319-562X
Subject:
alleles; asthma; childhood; children; genotype; genotyping; infants; introns; loci; lymphotoxin; pathogenesis; polymerase chain reaction; restriction fragment length polymorphism; risk; Saudi Arabia
Abstract:
... There is strong evidence that supports the role of tumour necrosis factors (TNF-alpha/beta) as common genetic factors, located on 6p21.1–6p21.3 loci, in the pathogenesis of asthma disease. In this study, we extended our research work on TNFA to include the genotyping of Saudi asthmatic children as regards to TNFB gene (namely as lymphotoxin-α, LTA). We examined 60 asthmatic Saudi children compared ...
DOI:
10.1016/j.sjbs.2010.10.006
PubMed:
23961111
PubMed Central:
PMC3730738

52. Association of Childhood Obesity and the Immune System: A Systematic Review of Reviews

Author:
Kelishadi Roya; Roufarshbaf Mohammad; Soheili Sina; Payghambarzadeh Farzaneh; Masjedi Mohsen
Source:
Childhood obesity 2017 v.13 no.4 pp. 332-346
ISSN:
2153-2176
Subject:
asthma; atopic dermatitis; autoimmune diseases; blood serum; childhood; childhood obesity; children; cytokines; databases; immune system; microorganisms; proteins; risk; sleep apnea; systematic review; vaccines
Abstract:
... The growing prevalence of childhood obesity has become a serious health problem over the past decades. As the immune system is greatly affected by excess weight, in this review of reviews, we discuss the findings of review articles about the relationship between childhood/maternal obesity and children's immune system. We searched English-language articles in PubMed, Scopus, ISI Thomson Reuters, an ...
DOI:
10.1089/chi.2016.0176

53. Association of Polymorphisms of STAT6 and SO₂ with Chinese Childhood Asthma: a Case-control Study

Author:
Qiang WANG; Xue Tao BAI; Dong Qun XU; Hong LI; Chun Yu XU; Jian Long FANG
Source:
Biomedical and environmental sciences 2011 v.24 no.6 pp. 670-677
ISSN:
0895-3988
Subject:
Chinese people; air; air pollution; alleles; asthma; case-control studies; childhood; children; computer software; exons; gene frequency; genotype; influenza; nitrogen dioxide; pollutants; risk factors; single nucleotide polymorphism; statistical analysis; sulfur dioxide
Abstract:
... OBJECTIVE: To investigate the association of polymorphisms of STAT6 gene and air pollutants of PM₁₀, NO₂, and SO₂, with asthma in Chinese children. METHODS: 418 subjects aged 14 years and under were recruited in a case-control study. The association between STAT6 polymorphisms and childhood asthma were tested by allele frequency, genotype analysis, and MDR analysis. Exposure to outdoor air polluta ...
DOI:
10.3967/0895-3988.2011.06.012

54. Association of filaggrin gene mutations and childhood eczema and wheeze with phthalates and phosphorus flame retardants in house dust: The Hokkaido study on Environment and Children's Health

Author:
Yu Ait Bamai; Atsuko Araki; Toshifumi Nomura; Toshio Kawai; Tazuru Tsuboi; Sumitaka Kobayashi; Chihiro Miyashita; Masae Takeda; Hiroshi Shimizu; Reiko Kishi
Source:
Environment international 2018 v.121 pp. 102-110
ISSN:
0160-4120
Subject:
drug therapy; flame retardants; odds ratio; genes; phosphorus; Japanese people; blood sampling; phosphates; gas chromatography-mass spectrometry; mutation; eczema; risk factors; phthalates; children; asthma; dust; childhood; lifestyle; cross-sectional studies; questionnaires; child health; experimental design; regression analysis; environmental factors; Japan
Abstract:
... Exposure to phthalates and phosphorus flame retardants (PFRs) is considered to be a risk factor for asthma and allergies. However, little is known about the contribution of loss-of-function mutations in the gene encoding filaggrin (FLG) gene, which are considered to be predisposing factors for eczema and asthma, to these associations. We investigated the associations between exposure to phthalates ...
DOI:
10.1016/j.envint.2018.08.046

55. Association of perfluoroalkyl substances exposure with impaired lung function in children

Author:
Xiao-Di Qin; Zhengmin (Min) Qian; Shyamali C. Dharmage; Jennifer Perret; Sarah Dee Geiger; Steven E. Rigdon; Steven Howard; Xiao-Wen Zeng; Li-Wen Hu; Bo-Yi Yang; Yang Zhou; Meng Li; Shu-Li Xu; Wen-Wen Bao; Ya-Zhi Zhang; Ping Yuan; Jia Wang; Chuan Zhang; Yan-Peng Tian; Min Nian; Xiang Xiao; Wen Chen; Yungling Leo Lee; Guang-Hui Dong
Source:
Environmental research 2017 v.155 pp. 15-21
ISSN:
0013-9351
Subject:
asthma; biomarkers; blood serum; case-control studies; childhood; children; confidence interval; lung function; odds ratio; perfluorocarbons; perfluorooctane sulfonic acid; perfluorooctanoic acid; questionnaires; regression analysis
Abstract:
... Previous studies have demonstrated associations between serum levels of perfluoroalkyl substances (PFASs) and asthma or asthma related-biomarkers. However, no studies have reported a possible relationship between PFASs exposure and lung function among children. The objective of the present study is to test the association between PFASs exposure and lung function in children from a high exposure ar ...
DOI:
10.1016/j.envres.2017.01.025

56. Association of phthalate exposure with thyroid function during pregnancy

Author:
Arash Derakhshan; Huan Shu; Maarten A.C. Broeren; Christian H. Lindh; Robin P. Peeters; Andreas Kortenkamp; Barbara Demeneix; Carl-Gustaf Bornehag; Tim I.M. Korevaar
Source:
Environment international 2021 v.157 pp. 106795
ISSN:
0160-4120
Subject:
asthma; blood serum; children; cyclohexanes; dicarboxylic acids; environment; humans; metabolites; phthalates; pregnancy; thyroid function; triiodothyronine
Abstract:
... The extent of thyroid disruptive effects of phthalates during pregnancy remains unclear.To investigate the association of maternal urinary phthalates with markers of the thyroid system during early pregnancy.Urinary concentrations of phthalate metabolites and serum concentrations of thyroid stimulating hormone (TSH), free and total thyroxine (FT4 and TT4) and free and total triiodothyronine (FT3 a ...
DOI:
10.1016/j.envint.2021.106795

57. Association of short-term increases in ambient air pollution and timing of initial asthma diagnosis among medicaid-enrolled children in a metropolitan area

Author:
Judy K. Wendt; Elaine Symanski; Thomas H. Stock; Wenyaw Chan; Xianglin L. Du
Source:
Environmental Research 2014 v.131 pp. 50-58
ISSN:
0013-9351
Subject:
air pollution; asthma; children; cold season; confidence interval; models; nitrogen dioxide; odds ratio; ozone; particulates; pollutants; regression analysis; urban population; warm season; Texas
Abstract:
... We investigated associations of short-term changes in ambient ozone (O3), fine particulate matter (PM2.5) and nitrogen dioxide (NO2) concentrations and the timing of new-onset asthma, using a large, high-risk population in an area with historically high ozone levels.The study population included 18,289 incident asthma cases identified among Medicaid-enrolled children in Harris County Texas between ...
DOI:
10.1016/j.envres.2014.02.013
PubMed:
24657516
PubMed Central:
PMC4502952

58. Association of time–location patterns with urinary cotinine among asthmatic children under household environmental tobacco smoke exposure

Author:
Kuan-Yen Tung; Kuen-Yuh Wu; Ching-Hui Tsai; Ming-Wei Su; Chien-Han Chen; Ming-Hung Lin; Yang-Ching Chen; Wen-Chia Wu; Yungling Leo Lee
Source:
Environmental Research 2013 v.124 pp. 7-12
ISSN:
0013-9351
Subject:
adults; air; asthma; atherosclerosis; biomarkers; childhood; children; cotinine; creatinine; gender; liquid chromatography; otitis media; phenotype; questionnaires; risk; smoking (habit); tandem mass spectrometry
Abstract:
... Environmental tobacco smoke (ETS) is a hazardous component of indoor air, and may increase the risk of respiratory diseases, atherosclerosis and otitis media in children. In this study, we explored the relationship between time inside the house, ETS exposure and urinary cotinine level, and also determined the association of time inside the house on asthma phenotypes when children exposed to ETS.A ...
DOI:
10.1016/j.envres.2013.03.002

59. Association of urban particle numbers and sources with lung function among children with asthma or allergies

Author:
Ya-Ru Li; Li-Ting Feng; Bing-Yu Chen; Ho Kim; Seung-Muk Yi; Yue Leon Guo; Chang-Fu Wu
Source:
Science of the total environment 2016 v.542 pp. 841-844
ISSN:
0048-9697
Subject:
schools; lung function; aerosols; ozone; confidence interval; children; pollution; asthma; air; Taiwan
Abstract:
... Previous studies have reported sources of particle number pollution in urban air, but have not evaluated relationships between respiratory health and these sources. We compared, among children with asthma or allergies, the associations of spirometric lung functions with increased exposure to source-specific versus size-segregated particle number concentrations (PNC). Hourly measurements of PNC wer ...
DOI:
10.1016/j.scitotenv.2015.10.098

60. Association of urinary bisphenols and triclosan with thyroid function during early pregnancy

Author:
Arash Derakhshan; Huan Shu; Robin P. Peeters; Andreas Kortenkamp; Christian H. Lindh; Barbara Demeneix; Carl-Gustaf Bornehag; Tim I.M. Korevaar
Source:
Environment international 2019 pp. -
ISSN:
0160-4120
Subject:
bisphenol F; bisphenol A; blood serum; bisphenol S; humans; triclosan; uncertainty; thyrotropin; triiodothyronine; pregnancy; children; asthma; gestational age; thyroid function; enzyme activity
Abstract:
... Bisphenols and triclosan are considered as potential thyroid disruptors. While mild alterations in maternal thyroid function can result in adverse pregnancy and child developmental outcomes, there is still uncertainty whether bisphenols can interfere with thyroid function during pregnancy.We aimed to investigate the association of urinary bisphenol A (BPA), bisphenol S (BPS), bisphenol F (BPF) and ...
DOI:
10.1016/j.envint.2019.105123

61. Association of urinary levels of bisphenols F and S used as bisphenol A substitutes with asthma and hay fever outcomes

Author:
Angelico Mendy; Pӓivi M. Salo; Jesse Wilkerson; Lydia Feinstein; Kelly K. Ferguson; Michael B. Fessler; Peter S. Thorne; Darryl C. Zeldin
Source:
Environmental research 2020 v.183 pp. 108944
ISSN:
0013-9351
Subject:
National Health and Nutrition Examination Survey; asthma; bisphenol A; bisphenol S; children; confidence interval; data analysis; hay fever; men; odds ratio; products and commodities; prospective studies; regression analysis; urine; United States
Abstract:
... Bisphenols F (BPF) and S (BPS) are bisphenol A (BPA) analogs used as substitutes in consumer products. Despite previous reports of BPA's association with asthma, no studies have examined its structural analogs in relation to asthma and allergy outcomes.To examine the association of urinary BPF, BPS, and BPA with asthma and hay fever in a US representative sample.We analyzed data from 3,538 partici ...
DOI:
10.1016/j.envres.2019.108944
PubMed:
31911000
PubMed Central:
PMC7167336

62. Associations between air pollution and pediatric eczema, rhinoconjunctivitis and asthma: A meta-analysis of European birth cohorts

Author:
Elaine Fuertes; Jordi Sunyer; Ulrike Gehring; Daniela Porta; Francesco Forastiere; Giulia Cesaroni; Martine Vrijheid; Mònica Guxens; Isabella Annesi-Maesano; Rémy Slama; Dieter Maier; Manolis Kogevinas; Jean Bousquet; Leda Chatzi; Aitana Lertxundi; Mikel Basterrechea; Ana Esplugues; Amparo Ferrero; John Wright; Dan Mason; Rosie McEachan; Judith Garcia-Aymerich; Bénédicte Jacquemin
Source:
Environment international 2020 v.136 pp. 105474
ISSN:
0160-4120
Subject:
absorbance; adverse effects; air pollution; asthma; children; confidence interval; eczema; exposure models; meta-analysis; nitrogen dioxide; odds ratio; particulates; regression analysis
Abstract:
... Uncertainly continues to exist regarding the role of air pollution on pediatric asthma and allergic conditions, especially as air pollution levels have started to decrease in recent decades.We examined associations of long-term air pollution levels at the home address with pediatric eczema, rhinoconjunctivitis and asthma prevalences in five birth cohorts (BIB, EDEN, GASPII, RHEA and INMA) from sev ...
DOI:
10.1016/j.envint.2020.105474

63. Associations between personal exposure to air pollutants and lung function tests and cardiovascular indices among children with asthma living near an industrial complex and petroleum refineries

Author:
Audrey Smargiassi; Mark S. Goldberg; Amanda J. Wheeler; Céline Plante; Marie-France Valois; Gary Mallach; Lisa Marie Kauri; Robin Shutt; Susan Bartlett; Marie Raphoz; Ling Liu
Source:
Environmental Research 2014 v.132 pp. 38-45
ISSN:
0013-9351
Subject:
air pollution; air quality; asthma; autocorrelation; benzene; blood pressure; children; drug therapy; emissions; environmental factors; heart rate; industry; lung function; monitoring; nationalities and ethnic groups; nitrogen dioxide; oxygen; particulates; petroleum; pollutants; polycyclic aromatic hydrocarbons; regression analysis; sulfur dioxide; temperature; Quebec
Abstract:
... The acute cardiorespiratory effects of air quality among children living in areas with considerable heavy industry have not been well investigated. We conducted a panel study of children with asthma living in proximity to an industrial complex housing two refineries in Montreal, Quebec, in order to assess associations between their personal daily exposure to air pollutants and changes in pulmonary ...
DOI:
10.1016/j.envres.2014.03.030

64. Associations between prenatal maternal urinary concentrations of personal care product chemical biomarkers and childhood respiratory and allergic outcomes in the CHAMACOS study

Author:
Kimberly Berger; Brenda Eskenazi; John Balmes; Nina Holland; Antonia M. Calafat; Kim G. Harley
Source:
Environment international 2018 v.121 pp. 538-549
ISSN:
0160-4120
Subject:
Bayesian theory; CD4-positive T-lymphocytes; asthma; biomarkers; childhood; children; cytokines; eczema; lung function; metabolites; molecular weight; personal care products; phenols; phthalates; pregnancy; risk; urine; women
Abstract:
... Personal care product chemicals may be contributing to risk for asthma and other atopic illnesses. The existing literature is conflicting, and many studies do not control for multiple chemical exposures.We quantified concentrations of three phthalate metabolites, three parabens, and four other phenols in urine collected twice during pregnancy from 392 women. We measured T helper 1 (Th1) and T help ...
DOI:
10.1016/j.envint.2018.09.027
PubMed:
30293015
PubMed Central:
PMC6239199

65. Associations between urban air pollution and pediatric asthma control in El Paso, Texas

Author:
Jennifer E. Zora; Stefanie Ebelt Sarnat; Amit U. Raysoni; Brent A. Johnson; Wen-Whai Li; Roby Greenwald; Fernando Holguin; Thomas H. Stock; Jeremy A. Sarnat
Source:
Science of the total environment 2013 v.448 pp. 56-65
ISSN:
0048-9697
Subject:
schools; carbon; nitrogen dioxide; toluene; benzene; adrenal cortex hormones; arid zones; weather; air; air quality; lung function; models; ozone; pollutants; children; particulates; asthma; immune response; temperature; traffic; questionnaires; surveys; air pollution; environmental indicators; Texas
Abstract:
... Exposure to traffic-related pollutants poses a serious health threat to residents of major urban centers around the world. In El Paso, Texas, this problem is exacerbated by the region's arid weather, frequent temperature inversions, heavy border traffic, and an aged, poorly maintained vehicle fleet. The impact of exposure to traffic pollution, particularly on children with asthma, is poorly unders ...
DOI:
10.1016/j.scitotenv.2012.11.067
PubMed:
23312496

66. Associations of Food Allergy and Other Allergic Conditions with Attention Deficit/Hyperactivity Disorder in US Children (P16-032-19)

Author:
Guifeng Xu; Buyun Liu; Wei Bao
Source:
Current developments in nutrition 2019 v.3 no.Supplement_1 pp. -
ISSN:
2475-2991
Subject:
asthma; children; confidence interval; data analysis; dermatitis; educational status; food allergies; household income; nationalities and ethnic groups; odds ratio; questionnaires; regression analysis; rhinitis; surveys; United States
Abstract:
... Association between allergic conditions and attention deficit/hyperactivity disorder (ADHD) is still debated. Although there are several studies confirmed associations between ADHD and allergic rhinitis and asthma, little is known about the association between food allergy and ADHD. We examined the association of food allergy and other allergic conditions with ADHD in US children. We analyzed data ...
DOI:
10.1093/cdn/nzz050.P16-032-19

67. Associations of air pollution, obesity and cardiometabolic health in young adults: The Meta-AIR study

Author:
Jeniffer S. Kim; Zhanghua Chen; Tanya L. Alderete; Claudia Toledo-Corral; Fred Lurmann; Kiros Berhane; Frank D. Gilliland
Source:
Environment international 2019 pp. -
ISSN:
0160-4120
Subject:
abdominal fat; adiposity; aerodynamics; air pollutants; air pollution; asthma; blood lipids; body mass index; child health; childhood; children; fasting; glucose; high density lipoprotein cholesterol; insulin; lipid composition; lipid metabolism; low density lipoprotein cholesterol; models; nitrogen dioxide; obesity; ozone; particulates; regression analysis; risk; roads; standard deviation; total nitrogen; triacylglycerols; very low density lipoprotein; young adults
Abstract:
... Growing evidence indicates exposure to air pollution contributes to obesity and cardiometabolic disease risk in children and adults, however studies are lacking in young adulthood, an important transitional period in the life course. The aim of this study was to examine the associations of short- and long-term regional ambient and near-roadway air pollution (NRAP) exposures on adiposity and cardio ...
DOI:
10.1016/j.envint.2019.105180
PubMed:
31622905
PubMed Central:
PMC6884139

68. Associations of household renovation materials and periods with childhood asthma, in China: A retrospective cohort study

Author:
Jialing Zhang; Chanjuan Sun; Wei Liu; Zhijun Zou; Yinping Zhang; Baizhan Li; Zhuohui Zhao; Qihong Deng; Xu Yang; Xin Zhang; Hua Qian; Yuexia Sun; Jan Sundell; Chen Huang
Source:
Environment international 2018 v.113 pp. 240-248
ISSN:
0160-4120
Subject:
asthma; cellulose; cement; childhood; children; cities; cohort studies; confidence interval; cough; demographic statistics; floors; furniture; health status; home furnishings; odds ratio; pregnancy; questionnaires; regression analysis; risk factors; wood; China
Abstract:
... Childhood asthma is prevalent in China. However, there is a lack of evidence on whether household renovation, including the materials used and the periods, are associated with the disease.To investigate the associations between household decoration materials and renovation periods, and childhood asthma and its related symptoms.During 2010–2012, a retrospective cohort study was initiated in seven c ...
DOI:
10.1016/j.envint.2018.02.001

69. Associations of personal exposure to air pollutants with airway mechanics in children with asthma

Author:
Linchen He; Zhen Li; Yanbo Teng; Xiaoxing Cui; Karoline K. Barkjohn; Christina Norris; Lin Fang; Lili Lin; Qian Wang; Xiaojian Zhou; Jianguo Hong; Feng Li; Yinping Zhang; James J. Schauer; Marilyn Black; Michael H. Bergin; Junfeng (Jim) Zhang
Source:
Environment international 2020 v.138 pp. 105647
ISSN:
0160-4120
Subject:
air; air flow; air pollutants; air pollution; air quality; asthma; blood; children; filtration; inflammation; lung function; models; ozone; particulates; suburban areas; China
Abstract:
... The importance of airway mechanics has been increasingly recognized in pediatric asthma. However, no studies have examined responses of airway mechanics to air pollution exposure in asthmatic children.In this panel study involving indoor air filtration manipulation that created a large gradient of personal exposure to PM₂.₅, the airway mechanics and lung function of 43 asthmatic children 5–13 year ...
DOI:
10.1016/j.envint.2020.105647

70. Associations of residential exposure to agricultural pesticides with asthma prevalence in adolescence: The PIAMA birth cohort

Author:
Joseph S. Bukalasa; Bert Brunekreef; Maartje Brouwer; Gerard H. Koppelman; Alet H. Wijga; Anke Huss; Ulrike Gehring
Source:
Environment international 2018 v.121 pp. 435-442
ISSN:
0160-4120
Subject:
adolescence; agricultural land; asthma; bulbs; childhood; children; cohort studies; confidence interval; corn; cough; cross-sectional studies; dyspnea; floriculture; irritant properties; odds ratio; pesticide application; pesticides; potatoes; questionnaires; regression analysis; respiratory system; risk; spatial data
Abstract:
... It has been suggested that children who are exposed to agricultural pesticides have an increased risk of asthma, but evidence for associations betweeen residential pesticide exposure and childhood asthma is inconsistent.To investigate the associations of residential pesticide exposure with the prevalence of asthma and related symptoms within a Dutch birth cohort study.In this cross-sectional analy ...
DOI:
10.1016/j.envint.2018.09.029

71. Associations of serum perfluoroalkyl acid levels with T-helper cell-specific cytokines in children: By gender and asthma status

Author:
Yu Zhu; Xiao-Di Qin; Xiao-Wen Zeng; Gunther Paul; Lidia Morawska; Ming-Wei Su; Ching-Hui Tsai; Si-Quan Wang; Yungling Leo Lee; Guang-Hui Dong
Source:
Science of the total environment 2016 v.559 pp. 166-173
ISSN:
0048-9697
Subject:
T-lymphocytes; acids; asthma; biomarkers; blood serum; childhood; children; females; humans; inflammation; interferon-gamma; interleukin-2; interleukin-4; interleukin-5; males; odds ratio; wildlife; Taiwan
Abstract:
... Perfluoroalkyl acids (PFAAs) are a group of common chemicals that ubiquitously exist in wildlife and humans. Experimental data suggest that they may alter T-lymphocyte functioning in situ by preferentially enhancing the development of T-helper 2 (TH2)- and inhibiting TH1-lymphocyte development and might increase allergic inflammation, but few human studies have been conducted. To evaluate the asso ...
DOI:
10.1016/j.scitotenv.2016.03.187

72. Associations of wildfire smoke PM2.5 exposure with cardiorespiratory events in Colorado 2011–2014

Author:
Jennifer D. Stowell; Guannan Geng; Eri Saikawa; Howard H. Chang; Joshua Fu; Cheng-En Yang; Qingzhao Zhu; Yang Liu; Matthew J. Strickland
Source:
Environment international 2019 pp. -
ISSN:
0160-4120
Subject:
adults; aerodynamics; asthma; bronchitis; cardiovascular diseases; chemical composition; children; climate change; epidemiological studies; exposure models; particulates; regression analysis; smoke; spatial data; wildfires; Colorado
Abstract:
... Substantial increases in wildfire activity have been recorded in recent decades. Wildfires influence the chemical composition and concentration of particulate matter ≤2.5 μm in aerodynamic diameter (PM2.5). However, relatively few epidemiologic studies focus on the health impacts of wildfire smoke PM2.5 compared with the number of studies focusing on total PM2.5 exposure.We estimated the associati ...
DOI:
10.1016/j.envint.2019.105151

73. Asthma and asthma related symptoms in 23,326 Chinese children in relation to indoor and outdoor environmental factors: The Seven Northeastern Cities (SNEC) Study

Author:
Fan Liu; Yang Zhao; Yu-Qin Liu; Yang Liu; Jing Sun; Mei-Meng Huang; Yi Liu; Guang-Hui Dong
Source:
Science of the total environment 2014 v.497-498 pp. 10-17
ISSN:
0048-9697
Subject:
Chinese people; air; air pollution; asthma; children; cities; confidence interval; cross-sectional studies; environmental factors; factories; monitoring; morbidity; nitrogen; nitrogen dioxide; odds ratio; ozone; pets; pollutants; regression analysis; sulfur dioxide; China
Abstract:
... Both the levels and patterns of outdoor and indoor air pollutants have changed dramatically during the last decade in China. However, few studies have evaluated the effects of the present air pollution on the health of Chinese children. This study examines the association between outdoor and indoor air pollution and respiratory diseases among children living in Liaoning, a heavy industrial provinc ...
DOI:
10.1016/j.scitotenv.2014.07.096

74. Asthma and body weight change: a 20-year prospective community study of young adults

Author:
Hasler, G.; Gergen, P.J.; Ajdacic, V.; Gamma, A.; Eich, D.; Rossler, W.; Angst, J.
Source:
International journal of obesity 2006 v.30 no.7 pp. 1111-1118
ISSN:
0307-0565
Subject:
weight gain; adolescence; morbidity; risk factors; children; asthma; obesity; weight loss; adults; disease incidence
Abstract:
... Objective: There is increasing evidence for an association between asthma and body weight change. The objectives of these analyses were to examine the temporal relationships of this association and to explore the role of childhood depression as an explanatory factor. Methods: Data were derived from six subsequent semistructured interviews on health habits and health conditions from a single-age co ...
DOI:
10.1038/sj.ijo.0803215
PubMed:
16491113

75. Asthma and obesity in childhood: on the road ahead

Author:
Peroni, D.G.; Pietrobelli, A.; Boner, A.L.
Source:
International journal of obesity 2010 v.34 no.4 pp. 599-605
ISSN:
0307-0565
Subject:
human diseases; phenotype; physical activity; inflammation; signs and symptoms (animals and humans); children; chronic diseases; asthma; obesity; lungs; breathing; child nutrition; disease diagnosis
Abstract:
... Epidemiological data show a link between asthma and obesity, suggesting many different mechanisms that may underlie the association. However, diagnosis of asthma is often self-reported by patients or caregivers. Definition of asthma is crucial, particularly in childhood. Obesity can be associated with symptoms commonly attributed to asthma, such as wheezing, dyspnoea and sleep apnoea. Obese subjec ...
DOI:
10.1038/ijo.2009.273
PubMed:
20065975

76. Asthma disease as cause of admission to hospitals due to exposure to ambient oxidants in Mashhad, Iran

Author:
Hamid Reza Ghaffari; Hamideh Ebrahimi Aval; Ahmad Alahabadi; Adel Mokammel; Ramzanali Khamirchi; Samira Yousefzadeh; Ehsan Ahmadi; Abolfazl Rahmani-Sani; Mehdi Estaji; Amin Ghanbarnejad; Abdolmajid Gholizadeh; Mahmoud Taghavi; Mohammad Miri
Source:
Environmental science and pollution research international 2017 v.24 no.35 pp. 27402-27408
ISSN:
0944-1344
Subject:
acute exposure; air pollutants; air pollution; antioxidants; asthma; children; cities; computer software; hospitals; models; monitoring; nitrogen dioxide; oxidants; ozone; sulfur dioxide; Iran
Abstract:
... Nowadays, asthma is one of the most common chronic respiratory diseases, worldwide. Many reports have emphasized the correlation between the short-term exposure to the ambient air pollutants and acute respiratory diseases, especially among children with asthmatic symptoms. The aim of this study was to evaluate the relationship between the exposure to three atmospheric antioxidants (NO₂, SO₂, and O ...
DOI:
10.1007/s11356-017-0226-5

77. Asthma exacerbations among asthmatic children receiving live attenuated versus inactivated influenza vaccines

Author:
G. Thomas Ray; Ned Lewis; Kristin Goddard; Pat Ross; Jonathan Duffy; Frank DeStefano; Roger Baxter; Nicola P. Klein
Source:
Vaccine 2017 v.35 no.20 pp. 2668-2675
ISSN:
0264-410X
Subject:
asthma; children; immunization; influenza vaccines; risk; risk reduction; California
Abstract:
... To investigate whether there is a difference in the risk of asthma exacerbations between children with pre-existing asthma who receive live attenuated influenza vaccine (LAIV) compared with inactivated influenza vaccine (IIV).We identified IIV and LAIV immunizations occurring between July 1, 2007 and March 31, 2014 among Kaiser Permanente Northern California members aged 2 to <18years with a histo ...
DOI:
10.1016/j.vaccine.2017.03.082
PubMed:
28404355
PubMed Central:
PMC6636629

78. Asthma, respiratory symptoms and lung function in children living near a petrochemical site

Author:
Enric Rovira; Anna Cuadras; Xavier Aguilar; Leonardo Esteban; Alícia Borràs-Santos; Jan-Paul Zock; Jordi Sunyer
Source:
Environmental Research 2014 v.133 pp. 156-163
ISSN:
0013-9351
Subject:
questionnaires; lung function; industry; residential areas; cough; pollutants; children; asthma; environmental hazards; adolescents; childhood; traffic; Spain
Abstract:
... Residential proximity to environmental hazards has been related to adverse health outcomes. Respiratory health and allergies in children living near petrochemical sites have not been extensively studied. We evaluated the association between residential proximity to the petrochemical site of Tarragona (Catalonia, Spain) and the prevalence of asthma, respiratory symptoms and lung function in childre ...
DOI:
10.1016/j.envres.2014.05.022

79. Astragalus membranaceus improves therapeutic efficacy of asthmatic children by regulating the balance of Treg/Th17 cells

Author:
Wei WANG; Qing-Bin LIU; Wei JING
Source:
Chinese journal of natural medicines 2019 v.17 no.4 pp. 252-263
ISSN:
1875-5364
Subject:
Astragalus membranaceus; Oriental traditional medicine; asthma; blood serum; childhood; children; density gradient centrifugation; flow cytometry; formononetin; genistein; high performance liquid chromatography; immunoglobulin E; interleukin-17; interleukin-23; isoquercitrin; isorhamnetin; kaempferol; lung function; mononuclear leukocytes; quercetin; remission; swine; therapeutics; transforming growth factor beta
Abstract:
... Astragalus membranaceus may be a potential therapy for childhood asthma but its driving mechanism remains elusive. The main components of A. membranaceus were identified by HPLC. The children with asthma remission were divided into two combination group (control group, the combination of budesonide and terbutaline) and A. membranaceus group (treatment group, the combination of budesonide, terbutal ...
DOI:
10.1016/S1875-5364(19)30029-9

80. Atopic heredity modifies the association between maternal vitamin D status in pregnancy and the risk of atopic disease in childhood: an observational study

Author:
Anna Amberntsson; Ellinor Carlson Kjellberg; Jenny van Odijk; Andrea Mikkelsen; Linnea Bärebring; Hanna Augustin
Source:
Nutrition journal 2022 v.21 no.1 pp. 32
ISSN:
1475-2891
Subject:
asthma; blood serum; childhood; children; eczema; food allergies; food frequency questionnaires; inheritance (genetics); observational studies; pregnancy; regression analysis; risk
Abstract:
... BACKGROUND: The relationship between maternal vitamin D status in pregnancy and the development of atopic diseases in the offspring has been frequently studied, but with contradictory results. Previous studies have found an inverse relation between maternal vitamin D in pregnancy and the risk of atopic diseases in the child. In contrast, others have found a higher maternal 25OHD to be related to a ...
DOI:
10.1186/s12937-022-00787-9

81. Atopic march, food allergy and food hypersensitivity in children and adolescents suffering from atopic dermatitis

Author:
Jarmila Čelakovská
Source:
Food and agricultural immunology 2015 v.26 no.4 pp. 590-600
ISSN:
0954-0105
Subject:
adolescence; adolescents; adulthood; antigens; asthma; atopic dermatitis; childhood; children; food allergies; rhinitis; risk
Abstract:
... Increases in allergic diseases have been well documented worldwide. Approximately one-third of children with severe atopic dermatitis (AD) were reported to suffer from IgE-mediated food allergy as well. Data sources concerning the food allergy, AD, and atopic march were accessed from Pubmed/MEDLINE. This review provides a summary of findings concerning the food allergy, food hypersensitivity react ...
DOI:
10.1080/09540105.2014.998636

82. Atopy history and the genomics of wheezing after influenza vaccination in children 6–59 months of age

Author:
E. Kathryn Miller; Logan Dumitrescu; Chelsea Cupp; Stacy Dorris; Sallee Taylor; Robert Sparks; Diane Fawkes; Virginia Frontiero; Anne M. Rezendes; Colin Marchant; Kathryn M. Edwards; Dana C. Crawford
Source:
Vaccine 2011 v.29 no.18 pp. 3431-3437
ISSN:
0264-410X
Subject:
DNA; asthma; atopy; children; clinical trials; genomics; influenza; risk factors; single nucleotide polymorphism; surveys; vaccination; vaccines; United States
Abstract:
... BACKGROUND: A multinational clinical trial compared the safety and efficacy of intranasal trivalent live attenuated influenza vaccine (LAIV) with intramuscular trivalent inactivated vaccine (TIV) in very young children prior to the 2004–5 influenza season [1]. Wheezing was noted more often in recipients of LAIV and laboratory-confirmed influenza infection was noted more often in recipients of TIV. ...
DOI:
10.1016/j.vaccine.2011.02.071
PubMed:
21396408
PubMed Central:
PMC3334304

83. Bayesian analysis of the short-term association of NO2 exposure with local burden of asthmatic symptoms in children

Author:
Vera van Zoest; Gerard Hoek; Frank Osei; Alfred Stein
Source:
Science of the total environment 2020 v.720 pp. 137544
ISSN:
0048-9697
Subject:
Bayesian theory; acute exposure; air pollution; air quality; asthma; burden of disease; children; cough; drug therapy; kriging; meta-analysis; models; nitrogen dioxide; odds ratio; Netherlands
Abstract:
... Short-term exposure to air pollution has been associated with exacerbation of respiratory diseases such as asthma. Substantial heterogeneity in effect estimates has been observed between previous studies. This study aims to quantify the local burden of daily asthma symptoms in asthmatic children in a medium-sized city. Air pollution exposure was estimated using the nearest sensor in a fine resolut ...
DOI:
10.1016/j.scitotenv.2020.137544

84. Bayesian integrative model for multi-omics data with missingness

Author:
Zhou Fang; Tianzhou Ma; Gong Tang; Li Zhu; Qi Yan; Ting Wang; Juan C Celedón; Wei Chen; George C Tseng; John Hancock
Source:
Bioinformatics 2018 v.34 no.22 pp. 3801-3808
ISSN:
1460-2059
Subject:
Bayesian theory; asthma; children; data collection; gene expression; genomics; methylation; models; multiomics; prediction; sample size; uncertainty
Abstract:
... Integrative analysis of multi-omics data from different high-throughput experimental platforms provides valuable insight into regulatory mechanisms associated with complex diseases, and gains statistical power to detect markers that are otherwise overlooked by single-platform omics analysis. In practice, a significant portion of samples may not be measured completely due to insufficient tissues or ...
DOI:
10.1093/bioinformatics/bty775
PubMed:
30184058
PubMed Central:
PMC6223369

85. Before the first breath: prenatal exposures to air pollution and lung development

Author:
Mariana Matera Veras; Nilmara de Oliveira Alves; Lais Fajersztajn; Paulo Saldiva
Source:
Cell and tissue research 2017 v.367 no.3 pp. 445-455
ISSN:
0302-766X
Subject:
DNA; adulthood; air pollutants; air pollution; asthma; childhood; children; hypoxia; inflammation; low birth weight; lungs; maternal exposure; oxidative stress; pregnancy complications; premature birth; urban areas
Abstract:
... Various environmental contaminants are known to impair the growth trajectories of major organs, indirectly (gestational exposure) or directly (postnatal exposure). Evidence associates pre-gestational and gestational exposure to air pollutants with adverse birth outcomes (e.g., low birth weight, prematurity) and with a wide range of diseases in childhood and later in life. In this review, we explor ...
DOI:
10.1007/s00441-016-2509-4

86. Benefits of influenza vaccination on the associations between ambient air pollution and allergic respiratory diseases in children and adolescents: New insights from the Seven Northeastern Cities study in China

Author:
Kangkang Liu; Shanshan Li; Zhengmin (Min) Qian; Shyamali C. Dharmage; Michael S. Bloom; Joachim Heinrich; Bin Jalaludin; Iana Markevych; Lidia Morawska; Luke D. Knibbs; Leslie Hinyard; Hong Xian; Shan Liu; Shao Lin; Ari Leskinen; Mika Komppula; Pasi Jalava; Marjut Roponen; Li-Wen Hu; Xiao-Wen Zeng; Wenbiao Hu; Gongbo Chen; Bo-Yi Yang; Yuming Guo; Guang-Hui Dong
Source:
Environmental pollution 2020 v.256 pp. 113434
ISSN:
0269-7491
Subject:
adolescents; aerodynamics; air pollutants; air pollution; allergic rhinitis; artificial intelligence; asthma; childhood; children; chronic exposure; cities; cross-sectional studies; influenza vaccination; influenza vaccines; issues and policy; models; nitrogen dioxide; particulates; questionnaires; risk; schools; surveys; China
Abstract:
... Little information exists on interaction effects between air pollution and influenza vaccination on allergic respiratory diseases. We conducted a large population-based study to evaluate the interaction effects between influenza vaccination and long-term exposure to ambient air pollution on allergic respiratory diseases in children and adolescents.A cross-sectional study was investigated during 20 ...
DOI:
10.1016/j.envpol.2019.113434

87. Benzo[a]pyrene is associated with dysregulated myelo-lymphoid hematopoiesis in asthmatic children

Author:
Hyunok Choi; Won-min Song; Minghui Wang; Radim J. Sram; Bin Zhang
Source:
Environment international 2019 v.128 pp. 218-232
ISSN:
0160-4120
Subject:
CD8-positive T-lymphocytes; DNA methylation; GATA transcription factors; artificial intelligence; asthma; benzo(a)pyrene; biosynthesis; childhood; children; data analysis; epigenetics; gene expression; glutathione transferase; hematopoiesis; heme; inflammation; regulator genes; stem cells; transcription (genetics); transcription factor NF-kappa B; umbilical cord; urban areas; urban population; Czech Republic
Abstract:
... The extent to which ambient benzo[a]pyrene (B[a]P) contributes to mechanistically distinct de novo asthma remains unknown.To identify molecular signatures and regulatory networks underlying childhood exposure to ambient B[a]P and asthma, using robust and unbiased systems biology approaches.Clinically confirmed asthmatic (n = 191) vs. control (n = 194) children (aged, 7–15) were enrolled from a pol ...
DOI:
10.1016/j.envint.2019.04.052

88. Biochemical effects of ozone on asthma during postnatal development

Author:
Richard L. Auten; W. Michael Foster
Source:
Biochimica et biophysica acta 2011 v.1810 no.11 pp. 1114-1119
ISSN:
0304-4165
Subject:
adults; antioxidants; asthma; children; infancy; ozone; postnatal development; respiratory physiology
Abstract:
... BACKGROUND: Ozone exposure during early life has the potential to contribute to the development of asthma as well as to exacerbate underlying allergic asthma. SCOPE OF REVIEW: Developmentally regulated aspects of sensitivity to ozone exposure and downstream biochemical and cellular responses. MAJOR CONCLUSIONS: Developmental differences in antioxidant defense responses, respiratory physiology, and ...
DOI:
10.1016/j.bbagen.2011.01.008
PubMed:
21276837
PubMed Central:
PMC3106122

89. Birch pollen-associated peanut allergies in children

Author:
Tamara Voskresensky Baričić; Slavica Dodig
Source:
Aerobiologia 2013 v.29 no.1 pp. 85-93
ISSN:
0393-5965
Subject:
Arachis hypogaea; Betula pendula; allergens; asthma; children; cross reaction; food plants; hay fever; immunoglobulin E; microarray technology; patients; peanuts; pollen; urticaria
Abstract:
... Panallergens show structural similarities, and they are responsible for many cross-reactions between pollen and plant food sources. The aim of the present study was to investigate IgE reactivity to peanut allergen components in children with birch pollen allergy. Patients experienced symptoms of allergic asthma, allergic rhinitis, and urticaria, and they underwent a complete diagnostic evaluation, ...
DOI:
10.1007/s10453-012-9265-z

90. Body composition in children with chronic inflammatory diseases: A systematic review

Author:
Noora Houttu; Marko Kalliomäki; Minna-Maija Grönlund; Harri Niinikoski; Merja Nermes; Kirsi Laitinen
Source:
Clinical nutrition 2020 v.39 no.9 pp. 2647-2662
ISSN:
0261-5614
Subject:
Crohn disease; adiposity; arthritis; asthma; celiac disease; children; children at risk; databases; guidelines; inflammation; juveniles; lean body mass; systematic review; ulcerative colitis
Abstract:
... Aberrations in body composition are expected in children suffering from chronic inflammatory conditions. The objective is to examine whether children with inflammatory bowel disease (IBD: Crohn's disease and ulcerative colitis), coeliac disease, asthma and juvenile idiopathic arthritis (JIA) have an altered body composition as compared to healthy children.A systematic review, registered in Prosper ...
DOI:
10.1016/j.clnu.2019.12.027

91. Boys with high body masses have an increased risk of developing asthma: findings from the National Longitudinal Survey of Youth (NLSY)

Author:
Mannino, D.M.; Mott, J.; Ferdinands, J.M.; Camargo, C.A. Jr.; Friedman, M.; Greves, H.M.; Redd, S.C.
Source:
International journal of obesity and related metabolic disorders : journal of the International Association for the Study of Obesity 2006 v.30 no.1 pp. 6-13
ISSN:
0307-0565
Subject:
boys; body mass index; asthma; risk factors; risk assessment; disease incidence; children; gender differences; girls
Abstract:
... Objective: To determine the relation between body mass index and the development of asthma in children. Design: Prospective study of 4393 asthma-free children followed for up to 14 years. Setting: Children of participants in the National Longitudinal Survey of Youth. Methods: Analysis was limited to children who were followed from birth and were asthma-free during the first 24 months of life. The ...
PubMed:
16344843

92. Breast feeding, hydrolysate formulas and delayed introduction of selected foods in the prevention of food hypersensitivity and allergic disease

Author:
Chandra, Ranjit Kumar
Source:
Nutrition research 2002 v.22 no.1-2 pp. 125-135
ISSN:
0271-5317
Subject:
asthma; breast feeding; children; eczema; eggs; fish; food allergies; foods; hydrolysates; hydrolysis; infants; lactation; morbidity; mortality; peanuts
Abstract:
... Allergy and atopic disease is a major cause of morbidity and mortality, particularly in young children. In all infants, especially in those with parental history of allergy, exclusive breast feeding for 4 months or longer, dietary precautions by the lactating mother, use of a hydrolyzed formula, and delayed introduction of egg, fish, and peanut have considerable value in preventing food allergy, e ...

93. Breast-feeding and hospitalization for asthma in early childhood: a nationwide longitudinal survey in Japan

Author:
Michiyo Yamakawa; Takashi Yorifuji; Tsuguhiko Kato; Yoshitada Yamauchi; Hiroyuki Doi
Source:
Public health nutrition 2015 v.18 no.10 pp. 1756-1761
ISSN:
1475-2727
Subject:
asthma; breast feeding; childhood; children; infancy; longitudinal studies; odds ratio; protective effect; regression analysis; risk reduction; siblings; smoking (habit); Japan
Abstract:
... Whether or not breast-feeding is protective against asthma among children is still controversial. Therefore, we examined the effects of breast-feeding on hospitalization for asthma in early childhood. Secondary data analyses of a nationwide longitudinal survey of children in Japan ongoing since 2001, with results collected from 2001 to 2004. We used logistic regression models to evaluate the assoc ...
DOI:
10.1017/S1368980014002407
PubMed:
25373365

94. Breastfeeding and Its Relationship to Childhood Respiratory Allergies and Allergic Asthma a Longitudinal Study (P11-104-19)

Author:
Galya Bigman
Source:
Current developments in nutrition 2019 v.3 no.Supplement_1 pp. -
ISSN:
2475-2991
Subject:
asthma; breast feeding; childhood; children; complementary foods; hypersensitivity; infant feeding; longitudinal studies; mothers; questionnaires; risk reduction; siblings; smoking (habit)
Abstract:
... Breastfeeding might be associated with respiratory allergy and asthma subtypes(i.e., allergic asthma), but such relations have never been examined yet in the US. Therefore, the aims of the study were: To examined the association between breastfeeding and respiratory allergy in children aged six years. To examined the association between breastfeeding and asthma including asthma subtypes (allergic) ...
DOI:
10.1093/cdn/nzz048.P11-104-19

95. Burden of higher lead exposure in African-Americans starts in utero and persists into childhood

Author:
Andrea E. Cassidy-Bushrow; Alexandra R. Sitarik; Suzanne Havstad; Sung Kyun Park; Lawrence F. Bielak; Christine Austin; Christine Cole Johnson; Manish Arora
Source:
Environment international 2017 v.108 pp. 221-227
ISSN:
0160-4120
Subject:
manganese; planning; at-risk population; lead; urban areas; Whites; blood; risk; public health; women; biomarkers; fetal development; neurotoxicity; toxic substances; pregnancy; children; asthma; childhood; growth rings; African Americans; longitudinal studies; Michigan
Abstract:
... Recent public health lead crises in urban areas emphasize the need to better understand exposure to environmental toxicants, particularly in higher risk groups. Although African-American children have the highest prevalence of elevated blood lead levels in the United States, little is known about when this trajectory of disproportionate burden of lead exposure first emerges.Using tooth-matrix biom ...
DOI:
10.1016/j.envint.2017.08.021
PubMed:
28886415
PubMed Central:
PMC5623116

96. Cadherin-related family member 3, a childhood asthma susceptibility gene product, mediates rhinovirus C binding and replication

Author:
Yury A. Bochkov; Kelly Watters; Shamaila Ashraf; Theodor F. Griggs; Mark K. Devries; Daniel J. Jackson; Ann C. Palmenberg; James E. Gern
Source:
Proceedings of the National Academy of Sciences of the United States of America 2015 v.112 no.17 pp. 5485-5490
ISSN:
0027-8424
Subject:
Rhinovirus C; asthma; binding sites; capsid; childhood; children; genes; genetic techniques and protocols; humans; models; single nucleotide polymorphism; transmembrane proteins
Abstract:
... Members of rhinovirus C (RV-C) species are more likely to cause wheezing illnesses and asthma exacerbations compared with other rhinoviruses. The cellular receptor for these viruses was heretofore unknown. We report here that expression of human cadherin-related family member 3 (CDHR3) enables the cells normally unsusceptible to RV-C infection to support both virus binding and replication. A codin ...
DOI:
10.1073/pnas.1421178112
PubMed:
25848009
PubMed Central:
PMC4418890

97. Can Early Omega-3 Fatty Acid Exposure Reduce Risk of Childhood Allergic Disease?

Author:
Elizabeth A. Miles; Philip C. Calder
Source:
Nutrients 2017 v.9 no.7 pp. -
ISSN:
2072-6643
Subject:
adolescence; allergens; arachidonic acid; asthma; atopic dermatitis; blood; childhood; children; epidemiological studies; fatty fish; fish consumption; fish oils; infants; omega-3 fatty acids; omega-6 fatty acids; pregnancy; pregnant women; risk reduction
Abstract:
... A causal link between increased intake of omega-6 (n-6) polyunsaturated fatty acids (PUFAs) and increased incidence of allergic disease has been suggested. This is supported by biologically plausible mechanisms, related to the roles of eicosanoid mediators produced from the n-6 PUFA arachidonic acid. Fish and fish oils are sources of long chain omega-3 (n-3) PUFAs. These fatty acids act to oppose ...
DOI:
10.3390/nu9070784
PubMed:
28754005
PubMed Central:
PMC5537898

98. Can the Pelargonium sidoides root extract EPs® 7630 prevent asthma attacks during viral infections of the upper respiratory tract in children?

Author:
Fulya Tahan; Melih Yaman
Source:
Phytomedicine 2013 v.20 pp. 148-150
ISSN:
0944-7113
Subject:
Pelargonium sidoides; asthma; chi-square distribution; children; chronic diseases; cough; fever; inflammation; muscles; nose; patients; therapeutics
Abstract:
... Asthma is a chronic disease characterized by airway inflammation. Viral infection initiates an immune inflammatory response that may produce asthma attacks. There is no effective preventing therapy for asthma attack during upper respiratory tract viral infections.To investigate the efficacy of 5 days of Pelargonium sidoides therapy for preventing asthma attack during upper respiratory tract viral ...
DOI:
10.1016/j.phymed.2012.09.022

99. Carers' perspectives on an effective Indigenous health model for childhood asthma in the Torres Strait

Author:
Patricia C. Valery; Lisa J. Whop; Noritta Morseu‐Diop; Gail Garvey; Ian B. Masters; Anne B. Chang
Source:
Australian journal of rural health 2016 v.24 no.3 pp. 170-175
ISSN:
1038-5282
Subject:
asthma; childhood; children; education; health services; models; parents; physicians; rural health; Queensland
Abstract:
... OBJECTIVE: To describe parents'/carers' views of the characteristics of a clinical service model shown to improve asthma outcomes. DESIGN: A randomised controlled study on education intervention for childhood asthma by Indigenous health care workers. SETTING: Thursday Island, Horn Island and Bamaga. PARTICIPANTS: Thirty‐five children received the intervention and 53 were in the control group. At t ...
DOI:
10.1111/ajr.12257

100. Changes in NADPH oxidase mRNA level can be detected in blood at inhaled corticosteroid treated asthmatic children

Author:
Zsuzsanna Ökrös; Emoke Endreffy; Zoltan Novak; Zoltan Maroti; Peter Monostori; Ilona Sz. Varga; Agnes Király; Sandor Turi
Source:
Life sciences 2012 v.91 no.19-20 pp. 907-911
ISSN:
0024-3205
Subject:
agonists; antioxidants; asthma; childhood; children; gene expression; heme oxygenase (biliverdin-producing); inflammation; isozymes; leukocytes; medical treatment; messenger RNA; oxidative stress; patients; quantitative polymerase chain reaction; thiobarbituric acid-reactive substances
Abstract:
... AIM: Oxidative stress, observed in the asthmatic airways, is not localized only to the bronchial system. It would be a great advantage to monitor the oxidative stress markers from blood especially in childhood asthma following the inflammation. Our aim was to measure the levels of antioxidants and the oxidatively damaged biomolecules. We were also interested in the gene expression alterations of t ...
DOI:
10.1016/j.lfs.2012.08.039