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1. Aligned microchannel polymer-nanotube composites for peripheral nerve regeneration: Small molecule drug delivery

Author:
Ohan S. Manoukian; Michael R. Arul; Swetha Rudraiah; Ivo Kalajzic; Sangamesh G. Kumbar
Source:
Journal of controlled release 2019 v.296 pp. 54-67
ISSN:
0168-3659
Subject:
4-aminopyridine; Schwann cells; anisotropy; autografting; biocompatibility; biodegradability; brain; chitosan; dose response; drugs; electrical treatment; encapsulation; halloysite; histology; humans; in vivo studies; laboratory animals; mechanical properties; modulus of elasticity; molecular weight; nanotubes; nerve growth factor; nerve regeneration; nerve tissue; porosity; proteins; rats; stem cells
Abstract:
... Peripheral nerve injury accounts for roughly 2.8% of all trauma patients with an annual cost of 7 billion USD in the U.S. alone. Current treatment options rely on surgical intervention with the use of an autograft, despite associated shortcomings. Engineered nerve guidance conduits, stem cell therapies, and transient electrical stimulation have reported to increase speeds of functional recovery. A ...
DOI:
10.1016/j.jconrel.2019.01.013
PubMed:
30658124
PubMed Central:
PMC6379151

2. Ameliorative effect of chitosan-conjugated 17α-methyltestosterone on testicular development in Clarias batrachus

Author:
Ratnadeep Saha; Irfan Ahmed Bhat; Ravi Charan; Suresh Babu Padinhate Purayil; Gopal Krishna; Annam Pavan Kumar; Rupam Sharma
Source:
Animal reproduction science 2018 v.193 pp. 245-254
ISSN:
0378-4320
Subject:
Clarias batrachus; adults; body weight; chitosan; dose response; gonadosomatic index; gonads; histology; methyltestosterone; nanoparticles; spawning; spermatogenesis; testicular development
Abstract:
... Chitosan nanoparticles conjugated with 17α-methyltestosterone (CS + MT) were used for studying their effect on the testicular development of Clarias batrachus during different reproductive phases. The size of chitosan nanoparticles was 127.2 nm and the nano-conjugated 17α methyltestosterone (17α-MT) was 196.1 nm (20 mg/100 ml of chitosan). Single injections of CS + MT at different doses such as 0. ...
DOI:
10.1016/j.anireprosci.2018.04.078

3. Aminoethyl-chitosan inhibits LPS-induced inflammatory mediators, iNOS and COX-2 expression in RAW264.7 mouse macrophages

Author:
Young-Sook Cho; Sang-Hoon Lee; Se-Kwon Kim; Chang-Bum Ahn; Jae-Young Je
Source:
Process biochemistry 2011 v.46 no.2 pp. 465-470
ISSN:
1359-5113
Subject:
Western blotting; biodegradability; biopolymers; chitosan; dose response; genes; inducible nitric oxide synthase; inflammation; interleukin-1beta; interleukin-6; lipopolysaccharides; macrophages; mice; necrosis; nitric oxide; prostaglandin synthase; prostaglandins; reverse transcriptase polymerase chain reaction; toxicity; transcription (genetics); transcription factor NF-kappa B; translation (genetics); tumor necrosis factor-alpha; water solubility
Abstract:
... Chitosan, naturally occuring biopolymer, has received considerable attention as a phamaceutical applications because of biocompatible, biodegradable and less toxic nature. In this study, chemically modified chitosans, aminoethyl-chitosans (AECs), were prepared in order to improve both water-solubility and bioactivity, and the effects of AECs on lipopolysaccharides (LPS)-induced inflammation in RAW ...
DOI:
10.1016/j.procbio.2010.09.019

4. Anti-inflammatory effect of chitosan oligosaccharides in RAW 264.7 cells

Author:
Eun-Jin Yang; Jong-Gwan Kim; Ji-Young Kim; Seong Kim; Nam Lee; Chang-Gu Hyun
Source:
Open life sciences 2010 v.5 no.1 pp. 95-102
ISSN:
2391-5412
Subject:
adverse effects; anti-inflammatory activity; chitosan; cytotoxicity; dose response; enzyme-linked immunosorbent assay; humans; immunoblotting; inducible nitric oxide synthase; interleukin-1beta; lipopolysaccharides; macrophages; molecular weight; nitric oxide; oligosaccharides; prostaglandin synthase; prostaglandins; protein synthesis; topical application
Abstract:
... We examined the effects of chitosan oligosaccharides (COSs) with different molecular weights (COS-A, 10 kDa < MW < 20 kDa; COS-C, 1 kDa < MW < 3 kDa) on the lipopolysaccharide (LPS)-induced production of prostaglandin E2 and nitric oxide and on the expression of cyclooxygenase-2 and inducible nitric oxide synthase in RAW264.7 macrophages. COS-A (0.4%) and COS-C (0.2%) significantly inhibited PGE2 ...
DOI:
10.2478/s11535-009-0066-5

5. Anti-migraine activity of freeze-dried latex obtained from Calotropis gigantea Linn

Author:
Saurabh Bhatia; Ahmed Al-Harrasi; Arun Kumar; Tapan Behl; Aayush Sehgal; Sukhbir Singh; Neelam Sharma; Md. Khalid Anwer; Deepak Kaushik; Vineet Mittal; Sridevi Chigurupati; Pritam Babu Sharma; Lotfi Aleya; Celia Vargas-de-la-Cruz; Md. Tanvir Kabir
Source:
Environmental science and pollution research 2022 v.29 no.18 pp. 27460-27478
ISSN:
0944-1344
Subject:
Calotropis gigantea; chitosan; color; dopamine; dose response; flavonoids; freeze drying; headache; hygroscopicity; latex; microencapsulation; migraine; pollution; research; serotonin; shelf life; solubility; water activity
Abstract:
... Migraine which is characterized by a pulsating headache affected an estimated population of 12% worldwide. Herbal products like latex derived from Calotropis gigantea R. Br. (Asclepiadaceae) are a representative intervention to treat migraine traditionally. However, post-harvesting stability issues of latex affect its biological potential. Freeze-drying has been successfully employed for the encap ...
DOI:
10.1007/s11356-021-17810-x

6. Antiageing activities of water-soluble chitosan from Clanis bilineata larvae

Author:
Shengjun Wu; Mingsheng Lu; Shujun Wang
Source:
International journal of biological macromolecules 2017 pp. -
ISSN:
0141-8130
Subject:
dose response; hydroxyl radicals; humans; malondialdehyde; chitosan; superoxide dismutase; mice; glutathione peroxidase; animal models; larvae; superoxide anion; antioxidant activity; dietary supplements
Abstract:
... Water extracts were prepared using water-soluble chitosan from Clanis bilineata larva skin. This study also investigated antioxidant and antiageing activities of water-soluble chitosan. Water-soluble chitosan of Clanis bilineata larva skin (CBLSWSC) showed considerable scavenging activities on superoxide anion and hydroxyl radicals and reducing capacity. Different doses of CBLSWSC were intragastri ...
DOI:
10.1016/j.ijbiomac.2017.04.038

7. Antifouling performance of in situ synthesized chitosan-zinc oxide hydrogel film against alga M. aeruginosa

Author:
Xueqin Zhao; Sen Zeng; Hua Feng; Yunhua Wang; Shuo Li; Xi Zhou; Miao Wang; Lei Rei
Source:
International journal of biological macromolecules 2022 v.200 pp. 234-241
ISSN:
0141-8130
Subject:
antifouling activities; cell membranes; chitosan; chlorophyll; dose response; growth retardation; hydrogels; mechanical properties; microalgae; solvents; water uptake; zinc oxide
Abstract:
... The undesirable settlement and growth of microalgae on submerged installations is a universal problem in water environment. Soft hydrogels are promising fouling-resistant materials due to the inherent surface properties. Herein, a kind of chitosan hydrogels with increasing zinc oxide (ZnO) mineral phase content were prepared by in situ sol–gel and solvent casting method, to prevent growth of algae ...
DOI:
10.1016/j.ijbiomac.2021.12.159

8. Antimicrobial activities of chitosan nanoparticles against pathogenic microorganisms in Nile tilapia, Oreochromis niloticus

Author:
Nashwa Abdel-Razek
Source:
Aquaculture international 2019 v.27 no.5 pp. 1315-1330
ISSN:
0967-6120
Subject:
Aeromonas hydrophila; Aeromonas sobria; Aspergillus flavus; Aspergillus fumigatus; Aspergillus niger; Candida; Fusarium; Mucor; Oreochromis niloticus; Pseudomonas aeruginosa; Pseudomonas fluorescens; Staphylococcus aureus; Streptococcus agalactiae; antimicrobial properties; bacteria; cell membranes; chitosan; cytoplasm; diet; digestive system; dose response; fish; fish diseases; fungi; gelation; hemorrhage; intraperitoneal injection; lethal dose; minimum inhibitory concentration; mortality; nanoparticles; necrosis; septicemia; signs and symptoms (animals and humans); spleen; swimming; therapeutics; transmission electron microscopes; tripolyphosphates; virulent strains; zeta potential
Abstract:
... Nanotechnology is a recent unique technique generally used for nutrition and therapy purposes among others. In this respect, the present study was carried out to evaluate the antimicrobial activity of chitosan nanoparticles (CNP) against various microorganisms (fungi and bacteria) isolated from diseased or health Nile tilapia, Oreochromis niloticus. The CNP was prepared based on the ionic gelation ...
DOI:
10.1007/s10499-019-00388-0

9. Antimicrobial activity of chitosan and a chitosan oligomer against bacterial pathogens of warmwater fish

Author:
M. Yildirim‐Aksoy; B.H. Beck
Source:
Journal of applied microbiology 2017 v.122 no.6 pp. 1570-1578
ISSN:
1364-5072
Subject:
Aeromonas hydrophila; Edwardsiella ictaluri; Flavobacterium columnare; Gram-negative bacteria; adsorption; antibacterial properties; antibiotics; cell death; cell membranes; chitosan; disease outbreaks; dose response; farmed fish; growth retardation; ions; lactic acid; microbial growth; oligosaccharides; pathogens
Abstract:
... AIM: The antibacterial activities of chitosan (CS) and its derivative chitosan oligosaccharide lactate (COL) were evaluated against Aeromonas hydrophila, Edwardsiella ictaluri and Flavobacterium columnare, three highly pathogenic bacteria of warmwater finfish. METHODS AND RESULTS: The magnitude and mode of antimicrobial action on Gram‐negative bacterial pathogens was investigated with an emphasis ...
DOI:
10.1111/jam.13460
CHORUS:
10.1111/jam.13460

10. Antimicrobial and antioxidant AIE chitosan-based films incorporating a Pickering emulsion of lemon myrtle (Backhousia citriodora) essential oil

Author:
Lingdai Liu; Simon Swift; Cherie Tollemache; Janesha Perera; Paul A. Kilmartin
Source:
Food hydrocolloids 2022 v.133 pp. 107971
ISSN:
0268-005X
Subject:
Backhousia citriodora; antioxidants; chitosan; dose response; emulsions; essential oils; fluorescence; hydrocolloids; lignin; mechanical stress; pH; ultrasonic treatment
Abstract:
... Films based on chitosan (CS) and Lemon Myrtle (Backhousia citriodora) essential oil (LEO) were prepared that exhibited novel dose-dependent fluorescent patterns owing to aggregation-induced emission (AIE) effects. Specifically, chitosan-coated alkali lignin (CS@AL) colloid particles were obtained by a facile one-pot ultrasonication, and were used to prepare LEO-loaded Pickering emulsions (CS@ALPE) ...
DOI:
10.1016/j.foodhyd.2022.107971

11. Antimicrobial efficacy of tobramycin polymeric nanoparticles for Pseudomonas aeruginosa infections in cystic fibrosis: Formulation, characterisation and functionalisation with dornase alfa (DNase)

Author:
Jill Deacon; Sharif M. Abdelghany; Derek J. Quinn; Daniela Schmid; Julianne Megaw; Ryan F. Donnelly; David S. Jones; Adrien Kissenpfennig; J. Stuart Elborn; Brendan F. Gilmore; Clifford C. Taggart; Christopher J. Scott
Source:
Journal of controlled release 2015 v.198 pp. 55-61
ISSN:
0168-3659
Subject:
DNA; Galleria mellonella; Pseudomonas aeruginosa; adverse effects; alginates; antimicrobial properties; bacteria; calorimetry; chitosan; cystic fibrosis; deoxyribonuclease I; dose response; drugs; humans; inoculum; longevity; lungs; minimum inhibitory concentration; models; mucus; nanoparticles; patients; polymers; survival rate; therapeutics; titration; tobramycin; toxicity
Abstract:
... Inhaled antibiotics, such as tobramycin, for the treatment of Pseudomonas aeruginosa pulmonary infections are associated with the increase in life expectancy seen in cystic fibrosis (CF) patients over recent years. However, the effectiveness of this aminoglycoside is still limited by its inability to penetrate the thick DNA-rich mucus in the lungs of these patients, leading to low antibiotic expos ...
DOI:
10.1016/j.jconrel.2014.11.022

12. Antioxidant effects of a dietary supplement: Reduction of indices of oxidative stress in normal subjects by water-soluble chitosan

Author:
Anraku, Makoto; Fujii, Takeshi; Furutani, Nobuko; Kadowaki, Daisuke; Maruyama, Toru; Otagiri, Masaki; Gebicki, Janusz M.; Tomida, Hisao
Source:
Food and chemical toxicology 2009 v.47 no.1 pp. 104-109
ISSN:
0278-6915
Subject:
nutrient intake; water solubility; high density lipoprotein; carbonyl compounds; dose response; serum albumin; humans; oxidative stress; chitosan; dosage; free radical scavengers; antioxidant activity; polymers; volunteers; dietary supplements; hydroperoxides; chitin
DOI:
10.1016/j.fct.2008.10.015
PubMed:
18996432

13. Application of nanoadsorbents for removal of lead from water

Author:
M. Bhatia; R. Satish Babu; S. H. Sonawane; P. R. Gogate; A. Girdhar; E. R. Reddy; M. Pola
Source:
International journal of environmental science and technology 2017 v.14 no.5 pp. 1135-1154
ISSN:
1735-1472
Subject:
adsorbents; adsorption; aluminum oxide; carbon nanotubes; chitosan; copper; cost effectiveness; dose response; effluents; guidelines; heavy metals; hematite; industry; ion exchange; ions; iron; lead; magnetite; nanoclays; nanoparticles; pH; reverse osmosis; surface area; titanium; zinc oxide; zirconium
Abstract:
... Enormous increase in the application of various heavy metals including lead for commercial and non-commercial purposes has also led to their enhanced occurrence in the effluents from industries and domestic discharge creating substantial environmental concerns. The existing techniques for removal of these contaminants such as reverse osmosis and ion exchange suffer a few disadvantages and hence, t ...
DOI:
10.1007/s13762-016-1198-6

14. Arthrospira platensis transglutaminase derived antioxidant peptide-packed electrospun chitosan/ poly (vinyl alcohol) nanofibrous mat accelerates wound healing, in vitro, via inducing mouse embryonic fibroblast proliferation

Author:
Anbazahan Sannasimuthu; Madhura Ramani; Bilal Ahamad Paray; Mukesh Pasupuleti; Mohammad K. Al-Sadoon; Tamil Selvi Alagumuthu; Abdul Rahman Al-Mfarij; Aziz Arshad; Kanchana Mala; Jesu Arockiaraj
Source:
Colloids and surfaces 2020 v.193 pp. 111124
ISSN:
0927-7765
Subject:
Arthrospira platensis; X-ray diffraction; antioxidant activity; biopharmaceuticals; chitosan; cytotoxicity; dose response; encapsulation; fibroblasts; fluorescence microscopy; free radicals; humans; leukocytes; mice; nanofibers; peptides; polyvinyl alcohol; protein-glutamine gamma-glutamyltransferase; transcriptome
Abstract:
... In this present study, we have carried out the antioxidant function of transglutaminase (TG) identified from Arthrospira platensis (Ap) transcriptome. The antioxidant peptide ML11 (MLRSIGIPARL) has been predicted from the transglutaminase core domain and the peptide’s free radical scavenging potential was evaluated and it shows that it functions on a dose dependent manner. The ML11 peptide cell to ...
DOI:
10.1016/j.colsurfb.2020.111124

15. Ascorbic acid prevents cellular uptake and improves biocompatibility of chitosan nanoparticles

Author:
Hisham A. Elshoky; Taher A. Salaheldin; Maha A. Ali; Mohamed H. Gaber
Source:
International journal of biological macromolecules 2018 v.115 pp. 358-366
ISSN:
0141-8130
Subject:
acetic acid; ascorbic acid; biocompatibility; chitosan; colorectal neoplasms; confocal laser scanning microscopy; cytotoxicity; dose response; drugs; genes; human cell lines; humans; nanoparticles; neoplasm cells; pH; particle size
Abstract:
... Chitosan nanoparticles have many applications, such as gene and drug delivery, due to their biocompatibility. Chitosan nanoparticles are currently produced by dissolution in acetic acid that affects the biocompatibility at acidic pH. Here, we synthesized and characterized chitosan (CS) and ascorbate chitosan (AsCS) nanoparticles and investigated their cytotoxic effects, internalization, and distri ...
DOI:
10.1016/j.ijbiomac.2018.04.055

16. Assessment of Oligo-Chitosan Biocompatibility toward Human Spermatozoa

Author:
Ulrike Schimpf; Gilai Nachmann; Stephane Trombotto; Petr Houska; Hongji Yan; Lars Björndahl; Thomas Crouzier
Source:
ACS applied materials & interfaces 2019 v.11 no.50 pp. 46572-46584
ISSN:
1944-8252
Subject:
DNA damage; adenosine triphosphate; biocompatibility; biocompatible materials; chitosan; coatings; dose response; drug carriers; glycolysis; humans; mitochondria; plasma membrane; reactive oxygen species; spermatozoa; tissue engineering
Abstract:
... The many interesting properties of chitosan polysaccharides have prompted their extensive use as biomaterial building blocks, for instance as antimicrobial coatings, tissue engineering scaffolds, and drug delivery vehicles. The translation of these chitosan-based systems to the clinic still requires a deeper understanding of their safety profiles. For instance, the widespread claim that chitosans ...
DOI:
10.1021/acsami.9b17605

17. Biomolecule-loaded chitosan nanoparticles induce apoptosis and molecular changes in cancer cell line (SiHa)

Author:
Anbu Sujima Anbu; Palanivel Velmurugan; ​Jeong-Ho Lee; Byung-Taek Oh; Perumal Venkatachalam
Source:
International journal of biological macromolecules 2016 v.88 pp. 18-26
ISSN:
0141-8130
Subject:
Cinnamomum verum; Fourier transform infrared spectroscopy; Gymnema sylvestre; X-ray diffraction; apoptosis; bark; chitosan; cytotoxicity; dose response; humans; inhibitory concentration 50; leaf extracts; leaves; light scattering; methanol; nanoparticles; transmission electron microscopy; uterine cervical neoplasms
Abstract:
... The present study reports on the synthesis of chitosan nanoparticles (CNPs) using methanol extracts of Gymnema sylvestre (GS) leaves and Cinnamomum zeylanicum (CZ) bark. Biomolecule-loaded nanoparticles induced apoptosis in a human cervical cancer (SiHa) cell line, and experiments were carried out to elucidate the underlying molecular mechanisms. FT-IR and XRD showed possible functional groups of ...
DOI:
10.1016/j.ijbiomac.2016.03.042

18. CO-Induced apoptotic death of colorectal cancer cells by a luminescent photoCORM grafted on biocompatible carboxymethyl chitosan

Author:
Indranil Chakraborty; Jorge Jimenez; P. K. Mascharak
Source:
Chemical communications 2017 v.53 no.40 pp. 5519-5522
ISSN:
1364-548X
Subject:
antineoplastic agents; apoptosis; biodegradability; chitosan; colorectal neoplasms; condensation reactions; confocal microscopy; dose response; fluorescence; neoplasm cells; rhenium; schiff bases
Abstract:
... A photo-active luminescent rhenium carbonyl complex namely, [Re(CO)₃(phen)(pyAl)](CF₃SO₃) was grafted on a biocompatible carboxymethyl chitosan (CMC) matrix through Schiff base condensation reaction. The light-induced CO delivery from ReCMC has been shown to eradicate human colorectal adenocarcinoma cells (HT-29) very efficiently in a dose-dependent fashion. The onset of CO-induced apoptosis was r ...
DOI:
10.1039/c7cc02842c
PubMed:
28466932
PubMed Central:
PMC5728991

19. Caffeic acid-conjugated chitosan derivatives and their anti-tumor activity

Author:
Sang Joon Lee; Mi-Sun Kang; Jong-Suk Oh; Hee Sam Na; You Jin Lim; Young-Il Jeong; Hyun Chul Lee
Source:
Archives of pharmacal research 2013 v.36 no.12 pp. 1437-1446
ISSN:
0253-6269
Subject:
anticarcinogenic activity; apoptosis; caffeic acid; cell viability; chemical composition; chitosan; colorectal neoplasms; cytotoxicity; dose response; neoplasm cells; nuclear magnetic resonance spectroscopy
Abstract:
... In this study, we synthesized caffeic acid (CFA)-conjugated chitosan (ChitoCFA) as an anti-cancer compound. CFA was conjugated to the amine groups of chitosan (ChitoCFA) and its chemical composition was confirmed using ¹H nuclear magnetic resonance spectra, which indicates that specific peaks of CFA was observed at ChitoCFA conjugates. The anti-cancer effects of CFA and ChitoCFA were studied using ...
DOI:
10.1007/s12272-013-0139-x

20. Carboxymethyl chitosan modulates the genotoxic risk and oxidative stress of perfluorooctanoic acid in Nile tilapia (Oreochromis niloticus)

Author:
Fagr Kh. Abdel-Gawad; Wagdy K.B. Khalil; Ahmed A. El-Kady; Ahmed I. Waly; Mosaad A. Abdel-Wahhab
Source:
Journal of the Saudi Society of Agricultural Sciences 2016 v.15 no.1 pp. 57-66
ISSN:
1658-077X
Subject:
DNA; DNA damage; Oreochromis niloticus; alanine transaminase; albumins; antioxidant activity; aspartate transaminase; chitosan; creatinine; diet; dose response; exposure pathways; fish; genotoxicity; humans; oxidative stress; perfluorooctanoic acid; pollutants; polyacrylamide gel electrophoresis; protective effect; protein content; risk; tissues
Abstract:
... Perfluorooctanoic acid (PFOA) is one of the most commonly used perfluorinated compounds. Being a persistent environmental pollutant, it can accumulate in human tissues via various exposure routes. The aim of the current study was to evaluate the protective role of carboxymethyl chitosan (CMC) against PFOA-induced toxicity at the genetic and protein levels in Nile tilapia using the biochemistry ana ...
DOI:
10.1016/j.jssas.2014.04.005

21. Characterization and antibacterial activity of ruthenium-based shikimate cross-linked chitosan composites

Author:
Ran Tao; Yin Lu; Wubing Xia; Changwei Zhang; Chengzhang Wang
Source:
International journal of biological macromolecules 2022 v.217 pp. 890-901
ISSN:
0141-8130
Subject:
antibacterial properties; biofilm; calcium; cell membranes; chitosan; coordination polymers; crosslinking; dose response; homogenization; microwave treatment; photosensitivity; quaternary ammonium compounds; ruthenium; shikimic acid; zeta potential
Abstract:
... The unsustainable antibacterial activity of ruthenium antibacterial agents is an important factor limiting their applications. This present work attempts to prepare ruthenium (Ru) coordination polymer composites with chitosan quaternary ammonium polymers (CQ) and shikimic acid (SA) through the interaction of ionic bonds and covalent bonds by microwave-assisted high-pressure homogenization methods. ...
DOI:
10.1016/j.ijbiomac.2022.07.205

22. Characterization of the Vibriocidal Activity of Chitosan Microparticles: A Potential Therapeutic Agent for Emerging Multidrug-Resistant Cholera Infections

Author:
Thomas A. Weppelmann; Kwangcheol Casey Jeong; Afsar Ali
Source:
ACS applied materials & interfaces 2020 v.12 no.42 pp. 47278-47288
ISSN:
1944-8252
Subject:
Gram-negative bacteria; O-antigens; Vibrio cholerae O1; antibacterial properties; cell viability; chitosan; cholera; diarrhea; dose response; fluorescence; growth retardation; lipid A; metabolism; multiple drug resistance; pH; permeability; salt content; therapeutics
Abstract:
... Due to increasing reports of multidrug-resistant (MDR) Vibrio cholerae O1, the goal of this study was to characterize the in vitro antimicrobial activity of chitosan microparticles (CMs) to evaluate their potential as a novel therapeutic agent for cholera. We examined the antimicrobial activity of CMs against toxigenic V. cholerae O1 using direct enumeration, microscopy, and fluorescence microplat ...
DOI:
10.1021/acsami.0c14313
CHORUS:
10.1021/acsami.0c14313

23. Characterization of the elicitor-induced biosynthesis and secretion of genistein from roots of Lupinus luteus L

Author:
Kneer, R.; Poulev, A.A.; Olesinski, A.; Raskin, I.
Source:
Journal of experimental botany 1999 v.50 no.339 pp. 1553-1559
ISSN:
0022-0957
Subject:
Lupinus luteus; roots; biosynthesis; secretion; genistein; hydroponics; root exudates; salicylic acid; chitosan; potassium cyanide; glyphosate; dose response; jasmonic acid; sodium fluoride; chemical constituents of plants; duration
Abstract:
... Genistein is a multi-functional isoflavonoid naturally secreted from roots of hydroponically grown legume plants. Roots of hydroponically cultivated yellow lupin (Lupinus luteus L.) plants, transferred into water secreted minor amounts of genistein (about 5 microgram g-1 fr. wt.). Secretion of genistein from L. luteus roots (rhizosecretion) was stimulated dramatically to over 100 microgram g-1 roo ...
DOI:
10.1093/jxb/50.339.1553

24. Chitin and chitosan from the Norway lobster by-products: Antimicrobial and anti-proliferative activities

Author:
Nadhem Sayari; Assaâd Sila; Baha Eddine Abdelmalek; Rihab Ben Abdallah; Semia Ellouz-Chaabouni; Ali Bougatef; Rafik Balti
Source:
International journal of biological macromolecules 2016 v.87 pp. 163-171
ISSN:
0141-8130
Subject:
Fourier transform infrared spectroscopy; Nephrops norvegicus; acetylation; anti-infective properties; antineoplastic activity; byproducts; cell proliferation; chitin; chitosan; colorectal neoplasms; cytotoxicity; dose response; fungi; humans; inhibitory concentration 50; neoplasm cells; nuclear magnetic resonance spectroscopy
Abstract:
... Chitin was recovered through enzymatic deproteinization of the Norway lobster (Nephrops norvegicus) processing by-products. The obtained chitin was characterized and converted into chitosan by N-deacetylation, the acid-soluble form of chitin. Chitosan samples were then characterized by Fourier transform infrared spectroscopy (FTIR) and 13 Cross polarization magic angle spinning nuclear magnetic re ...
DOI:
10.1016/j.ijbiomac.2016.02.057

25. Chitins and chitosans for the removal of total ammonia of aquaculture effluents

Author:
Fernanda Bernardi; Izabel Volkweis Zadinelo; Helton José Alves; Fábio Meurer; Lilian Dena dos Santos
Source:
Aquaculture 2018 v.483 pp. 203-212
ISSN:
0044-8486
Subject:
adsorbents; adsorption; ammonia; aquaculture; chemical composition; chitin; chitosan; dose response; effluents; freshwater; porosity; shrimp; surface area; wastewater
Abstract:
... This study aimed to evaluate efficiency of adsorption of chitins of marine and freshwater shrimps, three commercial chitosan and chitosan produced in laboratory in the removal of total ammonia synthetic effluents with different initial concentrations of ammonia and natural aquaculture effluents. The adsorbents were characterized in relation to degree of deacetylation, specific surface area and por ...
DOI:
10.1016/j.aquaculture.2017.10.027

26. Chitosan Influences the Expression of P-gp and Metabolism of Norfloxacin in Grass Carp

Author:
Kun Hu; Xinyan Xie; Yi-Ni Zhao; Yi Li; Jiming Ruan; Hao-Ran Li; Tianyi Jin; Xian-Le Yang
Source:
Journal of Aquatic Animal Health 2015 v.27 no.2 pp. 104-111
ISSN:
1548-8667
Subject:
Ctenopharyngodon idella; bioavailability; chitosan; dose response; drugs; fish; glycoproteins; high performance liquid chromatography; immunohistochemistry; intestines; messenger RNA; norfloxacin; oral administration; permeability; pharmacokinetics; protein synthesis
Abstract:
... The aim of this study was to investigate the relationship between the administration of chitosan (CTS), expression of permeability glycoprotein (P-gp), and the metabolism of norfloxacin (NOR) in Grass Carp Ctenopharyngodon idella . Fish were administrated with a single dose of either NOR, CTS, 1:5 NOR–CTS or 1:10 NOR–CTS. The P-gp expression was analyzed by immunohistochemistry and real time-PCR. ...
DOI:
10.1080/08997659.2014.993484

27. Chitosan and metal salt coagulant impacts on Cryptosporidium and microsphere removal by filtration

Author:
Brown, Trevor J.; Emelko, Monica B.
Source:
Water research 2009 v.43 no.2 pp. 331-338
ISSN:
0043-1354
Subject:
Cryptosporidium parvum; oocysts; dose response; chitosan; alum; turbidity; microbial contamination; water treatment; coagulants; filtration; metals; drinking water; pathogens
DOI:
10.1016/j.watres.2008.10.035
PubMed:
18996552

28. Chitosan attenuates dibutyltin-induced apoptosis in PC12 cells through inhibition of the mitochondria-dependent pathway

Author:
Xiaorui Wang; Junqiu Miao; Chaoqun Yan; Rui Ge; Taigang Liang; Enli Liu; Qingshan Li
Source:
Carbohydrate polymers 2016 v.151 pp. 996-1005
ISSN:
0144-8617
Subject:
apoptosis; biocides; biopolymers; caspase-9; cell viability; chitosan; cytochrome c; dibutyltin; dose response; free radical scavengers; gene expression; lactate dehydrogenase; membrane potential; messenger RNA; mitochondrial membrane; neuroprotective effect; neurotoxins; protein synthesis; quantitative polymerase chain reaction; rats; reactive oxygen species
Abstract:
... Dibutyltin (DBT) which was widely used as biocide and plastic stabilizer has been described as a potent neurotoxicant. Chitosan (CS), a natural nontoxic biopolymer, possesses a variety of biological activities including antibacterial, antifungal, free radical scavenging and neuroprotective activities. The present study was undertaken to investigate the protective effects of CS against DBT-induced ...
DOI:
10.1016/j.carbpol.2016.06.053

29. Chitosan biostimulant controls infection of cucumber by Phytophthora capsici through suppression of asexual reproduction of the pathogen

Author:
Fatematuz Zohara; Musrat Zahan Surovy; Amena Khatun; Md. F. R. K. Prince; Md. Abdul Mannan Akanda; Mahfuzur Rahman; Md. Tofazzal Islam
Source:
Acta agrobotanica 2019 v.72 no.1 pp. aa.1763
ISSN:
2300-357X
Subject:
Phytophthora capsici; asexual reproduction; biopolymers; chitin; chitosan; cucumbers; damping off; disease resistance; dose response; growth promotion; mycelium; pesticides; plant growth; plant pathogenic fungi; roots; seed germination; seed treatment; seedlings; seeds; shoots; sporangia; zoospores
Abstract:
... The biopolymer chitosan is a derivative of chitin, which can promote plant growth and protect plants from phytopathogens. This study aimed to evaluate the efficacy of chitosan as a biostimulant and a biorational agent to protect cucumber plants from damping-off disease caused by Phytophthora capsici. Cucumber seeds were treated with a range of chitosan concentrations, viz. 0, 125, 250, and 500 ppm ...
DOI:
10.5586/aa.1763

30. Chitosan disrupts biofilm formation and promotes biofilm eradication in Staphylococcus species isolated from bovine mastitis

Author:
Verónica Felipe; María Laura Breser; Luciana Paola Bohl; Elizabete Rodrigues da Silva; Carolina Andrea Morgante; Silvia Graciela Correa; Carina Porporatto
Source:
International journal of biological macromolecules 2019 v.126 pp. 60-67
ISSN:
0141-8130
Subject:
Staphylococcus aureus; Staphylococcus xylosus; antibiotic resistance; antibiotics; antimicrobial properties; bacteria; biofilm; biopolymers; bovine mastitis; chitosan; dairy cattle; dose response; fungi; molecular weight; pathogens; plankton; staphylococcal infections; viability
Abstract:
... Staphylococci are the main pathogens associated with hard-to-control intramammary infections in dairy cattle, and bacterial biofilms are suspected to be responsible for the antimicrobial resistance and persistence of this disease. Biofilms have the ability to resist to higher levels of antibiotics and reduce their efficacy. It is thus necessary to develop strategies targeted to bacterial biofilm i ...
DOI:
10.1016/j.ijbiomac.2018.12.159

31. Chitosan extracted from Aspergillus flavus shows synergistic effect, eases quorum sensing mediated virulence factors and biofilm against nosocomial pathogen Pseudomonas aeruginosa

Author:
Sahira Nsayef Muslim; Israa M.S. AL Kadmy; Alaa Naseer Mohammed Ali; Batool Kadham Salman; Mohammad Ahmad; Saba Saadoon Khazaal; Nadheema Hammood Hussein; Sraa Nsayef Muslim
Source:
International journal of biological macromolecules 2017 pp. -
ISSN:
0141-8130
Subject:
Aspergillus flavus; Bacillus subtilis; Lactobacillus paracasei; Pseudomonas aeruginosa; adjuvants; antibacterial properties; antibiotics; bacterial infections; biofilm; chitosan; cross infection; dose response; gene expression; genes; pH; pathogens; phenotype; proteinases; pyocyanin; quorum sensing; scanning electron microscopy; solubility; staining; synergism; virulence
Abstract:
... The biological methods for extraction of chitosan were used as alternative procedures for chemical methods In biological methods, the chitosan was extracted from A. flavus by using of Lactobacillus paracasei for demineralization and Bacillus subtilis for deproteinization. The yield of extracted chitosan reached to 53.8%, pH was 7.8 and complete solubility in 1% acitic acid. Purified chitosan had t ...
DOI:
10.1016/j.ijbiomac.2017.08.146

32. Chitosan extracted from marine biowaste mitigates staphyloxanthin production and biofilms of Methicillin- resistant Staphylococcus aureus

Author:
Durairajan Rubini; Sanaulla Farisa Banu; B. Narayanan Veda Hari; Durai Ramya Devi; Shanmugaraj Gowrishankar; Shunmugiah Karutha Pandian; Paramasivam Nithyanand
Source:
Food and chemical toxicology 2018 v.118 pp. 733-744
ISSN:
0278-6915
Subject:
Portunus sanguinolentus; biofilm; cell lines; chitosan; confocal laser scanning microscopy; crabs; cytotoxicity; dose response; epithelial cells; exopolysaccharides; lungs; methicillin-resistant Staphylococcus aureus; multiple drug resistance; reactive oxygen species; scanning electron microscopy; toxicology; virulence; wastes
Abstract:
... Multidrug-resistant (MDR) Staphylococcus aureus is a major cause of biofilm-associated and indwelling device related infections. The present study explores the anti-virulent and antibiofilm potency of chitosan extracted from the shells of the marine crab Portunus sanguinolentus against Methicillin Resistant Staphylococcus aureus (MRSA). The chemical characterization results revealed that the extra ...
DOI:
10.1016/j.fct.2018.06.017

33. Chitosan nanoparticles enhance the antibacterial activity of the native polymer against bovine mastitis pathogens

Author:
María Soledad Orellano; Paula Isaac; Maria Laura Breser; Luciana Paola Bohl; Agustín Conesa; Rubén Dario Falcone; Carina Porporatto
Source:
Carbohydrate polymers 2019 pp. -
ISSN:
0144-8617
Subject:
Staphylococcus; antibacterial properties; antibiotics; bacteria; biofilm; bovine mastitis; chitosan; chronic diseases; dairy cows; dose response; innate immunity; nanocomposites; nanoparticles; pathogens; polymers; therapeutics; viability
Abstract:
... Staphylococcus is the most commonly isolated genus from animals with intramammary infections, and mastitis is the most prevalent disease that affects dairy cows in many countries. These pathogens can live in biofilms, a self-produced matrix, which allow them evade the innate immune system and the antibiotic therapy, thereby producing persistent infections. The aim of this study was to explore the ...
DOI:
10.1016/j.carbpol.2019.02.016

34. Chitosan nanoparticles for combined drug delivery and magnetic hyperthermia: From preparation to in vitro studies

Author:
Vanessa Zamora-Mora; Mar Fernández-Gutiérrez; Álvaro González-Gómez; Beatriz Sanz; Julio San Román; Gerardo F. Goya; Rebeca Hernández; Carmen Mijangos
Source:
Carbohydrate polymers 2017 v.157 pp. 361-370
ISSN:
0144-8617
Subject:
cell viability; chitosan; crosslinking; cytotoxicity; dose response; fever; fibroblasts; fluorouracil; humans; in vitro studies; nanocarriers; nanoparticles; neoplasm cells; neoplasms; tripolyphosphates
Abstract:
... Chitosan nanoparticles (CSNPs) ionically crosslinked with tripolyphosphate salts (TPP) were employed as nanocarriers in combined drug delivery and magnetic hyperthermia (MH) therapy. To that aim, three different ferrofluid concentrations and a constant 5-fluorouracil (5-FU) concentration were efficiently encapsulated to yield magnetic CSNPs with core-shell morphology. In vitro experiments using no ...
DOI:
10.1016/j.carbpol.2016.09.084

35. Chitosan nanoparticles reduce LPS-induced inflammatory reaction via inhibition of NF-κB pathway in Caco-2 cells

Author:
Jue Tu; Yinglei Xu; Jianqin Xu; Yun Ling; Yueqin Cai
Source:
International journal of biological macromolecules 2016 v.86 pp. 848-856
ISSN:
0141-8130
Subject:
Toll-like receptor 4; anti-inflammatory activity; chitosan; dose response; drug carriers; electrical resistance; epithelium; gene expression; gene expression regulation; human cell lines; inflammation; interleukin-8; messenger RNA; nanoparticles; permeability; polymerase chain reaction; secretion; signal transduction; transcription factor NF-kappa B; tumor necrosis factor-alpha
Abstract:
... Chitosan nanoparticles (CNP), an extensively oral-administered drug carrier, was investigated for the anti-inflammatory effects on LPS-inflamed Caco-2 cells and the relate mechanisms. CNP could alleviate the decrease of transepithelial electrical resistance (TEER) induced by LPS in Caco-2 monolayer, and significantly inhibit LPS-induced production of TNF-α, MIF, IL-8 and MCP-1 in a dose-dependent ...
DOI:
10.1016/j.ijbiomac.2016.02.015

36. Chitosan nanoparticles’ functionality as redox active drugs through cytotoxicity, radical scavenging and cellular behaviour

Author:
Sreelatha Sarangapani; Ajeetkumar Patil; Yoke Keng Ngeow; Rosmin Elsa Mohan; Anand Asundi; Matthew J. Lang
Source:
Integrative biology 2018 v.10 no.5 pp. 313-324
ISSN:
1757-9708
Subject:
antioxidant activity; apoptosis; biocompatibility; caspases; cell proliferation; chitosan; cytotoxicity; dose response; drugs; enzyme activity; free radical scavengers; glutathione; image analysis; nanoparticles; neoplasm cells; oxidative stress; propidium; reactive oxygen species; staining; stress response; therapeutics
Abstract:
... Targeting the oxidative stress response has recently emerged as a promising strategy for the development of therapeutic drugs for a broad spectrum of diseases. Supporting this strategy, we have reported that chitosan nanoparticles synthesized with a controlled size had selective cytotoxicity in leukemia cells through the mechanism related to reactive oxygen species (ROS) generation. Herein, we fou ...
DOI:
10.1039/c8ib00038g

37. Chitosan oligosaccharide inhibits EGF-induced cell growth possibly through blockade of epidermal growth factor receptor/mitogen-activated protein kinase pathway

Author:
Qingsong Xu; Wenjing Wang; Wen Yang; Yuguang Du; Linsheng Song
Source:
International journal of biological macromolecules 2017 v.98 pp. 502-505
ISSN:
0141-8130
Subject:
carcinogenesis; cell growth; chitosan; dose response; epidermal growth factor; epidermal growth factor receptors; epithelial cells; epithelium; metastasis; mitogen-activated protein kinase; neoplasms; oligosaccharides; phosphorylation; signal transduction
Abstract:
... Chitosan oligosaccharide (COS) has been shown to regulate various cellular and biological functions. Epidermal growth factor (EGF) plays a significant role in tumorigenesis and invasiveness of some cancers. The aim of this study was to evaluate the effects of COS on EGF-induced cell growth and the further mechanisms. The results demonstrated that COS could inhibit EGF-induced epithelial GE11 cells ...
DOI:
10.1016/j.ijbiomac.2017.02.021

38. Chitosan oligosaccharides inhibit epithelial cell migration through blockade of N-acetylglucosaminyltransferase V and branched GlcNAc structure

Author:
Qingsong Xu; Wenjing Wang; Chen Qu; Jianguo Gu; Heng Yin; Zhihao Jia; Linsheng Song; Yuguang Du
Source:
Carbohydrate polymers 2017 v.170 pp. 241-246
ISSN:
0144-8617
Subject:
Datura stramonium; N-acetylglucosamine; breast neoplasms; breasts; cell movement; chitosan; dose response; epithelial cells; lectins; metastasis; oligosaccharides; phytohemagglutinin; protein synthesis
Abstract:
... Chitosan oligosaccharides (COS) have been shown to regulate various cellular and biological functions. The aim of this study was to investigate the antimetastatic potency of COS and the underlying mechanism. Here, we established a stably N-acetylglucosaminyltransferase V (GnT-V)-overexpressed MCF10A cell line. As expected, GnT-V overexpression greatly promoted cell migration in the transfectants b ...
DOI:
10.1016/j.carbpol.2017.04.075

39. Chitosan-based polymer hybrids for thermo-responsive nanogel delivery of curcumin

Author:
Jittima Amie Luckanagul; Chutamart Pitakchatwong; Pahweenvaj Ratnatilaka Na Bhuket; Chawanphat Muangnoi; Pranee Rojsitthisak; Suwabun Chirachanchai; Qian Wang; Pornchai Rojsitthisak
Source:
Carbohydrate polymers 2018 v.181 pp. 1119-1127
ISSN:
0144-8617
Subject:
cell viability; chitosan; composite polymers; confocal microscopy; curcumin; cytotoxicity; dose response; fluorescence emission spectroscopy; hydrogels; nanoparticles; nuclear magnetic resonance spectroscopy; sonication; therapeutics; transmission electron microscopy; viability assays
Abstract:
... The purpose of this study is to design and develop thermoresponsive nano-sized hydrogel particles from a natural polymer, chitosan, as smart material platforms for curcumin delivery. Chitosan was used as the backbone material to be grafted with poly–(N-isopropylacrylamide) (pNIPAM) using an EDC/NHS coupling reaction. The conjugated products were characterized by ¹H NMR and TGA. Chitosan-grafted pN ...
DOI:
10.1016/j.carbpol.2017.11.027

40. Chitosan-graft-(PEI-β-cyclodextrin) copolymers and their supramolecular PEGylation for DNA and siRNA delivery

Author:
Yuan Ping; Chengde Liu; Zhongxing Zhang; Kerh Li Liu; Jianhai Chen; Jun Li
Source:
Biomaterials 2011 v.32 no.32 pp. 8328-8341
ISSN:
0142-9612
Subject:
beta-cyclodextrin; cations; chemical bonding; chitosan; composite polymers; cytotoxicity; dose response; ethylene glycol; gel chromatography; gene silencing; genes; luciferase; molecular weight; nanoparticles; nuclear magnetic resonance spectroscopy; plasmids; small interfering RNA; transfection
Abstract:
... Two water-soluble chitosan-graft-(polyethylenimine-β-cyclodextrin) (CPC) cationic copolymers were synthesized via reductive amination between oxidized chitosan (CTS) and low molecular weight polyethylenimine-modified β-cyclodextrin (β-CD-PEI). The two polycations, termed as CPC1 and CPC2, were characterized by proton nuclear magnetic resonance spectroscopy, gel permeation chromatography, and eleme ...
DOI:
10.1016/j.biomaterials.2011.07.038

41. Chitosan: a Safe Alternative to Synthetic Fungicides to Manage Dry Rot in Stored Potatoes

Author:
Pinky Raigond; Vinay Sagar; Tanuja Mishra; Asha Thakur; Brajesh Singh; Vinod Kumar; Vijai Kishor Gupta; Som Dutt; Sushil Sudhakar Changan
Source:
Potato research 2019 v.62 no.4 pp. 393-409
ISSN:
0014-3065
Subject:
Fusarium; chitosan; cold storage; color; cultivars; dose response; fungicides; incidence; postharvest losses; potatoes; processing quality; relative humidity; research; shelf life; storage time; sugars; temperature; tubers; weight loss
Abstract:
... Sub-tropicalisation of potato has increased the threat of dry rot during postharvest potato storage at elevated temperatures (10–12 °C). Potatoes meant for processing are generally stored at 10–12 °C, where not only sugars accumulate during prolonged storage, also Fusarium species affects the tuber quality and leads to more losses. Therefore, the present study aimed to reduce the physiological and ...
DOI:
10.1007/s11540-019-9421-8

42. Chitosan–Lysozyme Conjugates for Enzyme-Triggered Hydrogel Degradation in Tissue Engineering Applications

Author:
Soyon Kim; Zhong-Kai Cui; Bonhye Koo; Jiwen Zheng; Tara Aghaloo; Min Lee
Source:
ACS applied materials & interfaces 2018 v.10 no.48 pp. 41138-41145
ISSN:
1944-8252
Subject:
blue light; bone formation; cell proliferation; chitosan; crosslinking; dose response; encapsulation; enzyme substrates; hydrogels; irradiation; lysozyme; materials science; mesenchymal stromal cells; mice; moieties; porosity; riboflavin; scanning electron microscopy; tissue engineering; tissue repair
Abstract:
... Tuning hydrogel degradation enables effective and successful tissue regeneration by modulating cellular behaviors and matrix formation. In this work, we develop a novel degradable hydrogel scaffold on the basis of a unique enzyme–substrate complex by photocrosslinking. Chitosan and lysozyme are chemically modified with methacrylate moieties to be tethered in hydrogels, and in the presence of ribof ...
DOI:
10.1021/acsami.8b15591
PubMed:
30421603
PubMed Central:
PMC6453716

43. Chronic wound dressings – Pathogenic bacteria anti-biofilm treatment with bacterial cellulose-chitosan polymer or bacterial cellulose-chitosan dots composite hydrogels

Author:
Danica Z. Zmejkoski; Nemanja M. Zdravković; Dijana D. Trišić; Milica D. Budimir; Zoran M. Marković; Natalia O. Kozyrovska; Biljana M. Todorović Marković
Source:
International journal of biological macromolecules 2021 v.191 pp. 315-323
ISSN:
0141-8130
Subject:
absorption; biofilm; cellulose; chitosan; dose response; encapsulation; gamma radiation; hydrogels; irradiation; polymers; porosity; surface roughness
Abstract:
... Since the pathogenic bacteria biofilms are involved in 70% of chronic infections and their resistance to antibiotics is increased, the research in this field requires new healing agents.New composite hydrogels were designed as potential chronic wound dressings composed of bacterial cellulose (BC) with chitosan polymer (Chi) – BC-Chi and chitosan nanoparticles (nChiD) – BC-nChiD. nChiD were obtaine ...
DOI:
10.1016/j.ijbiomac.2021.09.118

44. Combined effect of chitosan and water activity on growth and fumonisin production by Fusarium verticillioides and Fusarium proliferatum on maize-based media

Author:
Laura V. Ferrochio; Eugenia Cendoya; Vanessa G.L. Zachetti; Maria C. Farnochi; Walter Massad; Maria L. Ramirez
Source:
International journal of food microbiology 2014 v.185 pp. 51-56
ISSN:
0168-1605
Subject:
Fusarium proliferatum; Fusarium verticillioides; animal and human health; chitosan; corn; dose response; food contamination; fumonisins; markets; molecular weight; water activity
Abstract:
... The objectives of the present study were to determine the in vitro efficacy of chitosan (0.5, 1.0, 2.0 and 3.0mg/mL) under different water availabilities (0.995, 0.99, 0.98, 0.96 and 0.93) at 25°C on lag phase, growth rate and fumonisin production by isolates of Fusarium verticillioides and Fusarium proliferatum. The presence of chitosan affected growth and fumonisin production, and this effect wa ...
DOI:
10.1016/j.ijfoodmicro.2014.05.011

45. Comparative antibacterial effects of cellulose nanofiber, chitosan nanofiber, chitosan/cellulose combination and chitosan alone against bacterial contamination of Iranian banknotes

Author:
Simin Zarayneh; Abbas Akhavan Sepahi; Mehdi Jonoobi; Hassan Rasouli
Source:
International journal of biological macromolecules 2018 v.118 pp. 1045-1054
ISSN:
0141-8130
Subject:
Bacillus pumilus; Bacillus subtilis; Brevibacterium; Escherichia coli; Gram-positive bacteria; Micrococcus; Staphylococcus aureus; Stenotrophomonas maltophilia; antibacterial properties; bacterial contamination; cellulose; chitosan; coatings; dose response; durability; nanofibers; synergism; toxicity
Abstract:
... The aims of the current study were to evaluate the antibacterial effects of cellulose nanofiber (CNF), chitosan nanofiber (ChNF), CNF/ChNF combination and chitosan alone (Ch) against the isolated bacterial contaminations from the surface of Iranian banknotes using biochemical, disc diffusion and molecular analyses. The results unveiled that the CNF did not show the significant antibacterial effect ...
DOI:
10.1016/j.ijbiomac.2018.06.160

46. Comparison of the ability of partially N-acetylated chitosan and chitooligosaccharides to elicit resistance reactions in wheat leaves

Author:
Vander, P.; Varum, K.M.; Domard, A.; El-Gueddari, N.E.; Moerschbacher, B.M.
Source:
Plant physiology 1998 v.118 no.4 pp. 1353-1359
ISSN:
0032-0889
Subject:
Triticum aestivum; leaves; plant pathogenic fungi; pathogenicity; disease resistance; chitosan; dose response; oligosaccharides; lignin; biosynthesis; polymerization
Abstract:
... Chitin, a linear polysaccharide composed of (1 leads to 4)-linked 2-acetamido-2-deoxy-beta-D-glucopyranose (GlcNAc) residues, and chitosan, the fully or partially N-acetylated, water-soluble derivative of chitin composed of (1 leads to 4)-linked GlcNAc and 2-amino-2-deoxy-beta-D-glucopyranose (GlcN), have been proposed as elicitors of defense reactions in higher plants. We tested and compared the ...

47. Construction and in vitro evaluation of enzyme nanoreactors based on carboxymethyl chitosan for arginine deprivation in cancer therapy

Author:
Tian Zeng; Yi Zhang; Qiongjiao Yan; Zhijun Huang; Ling Zhang; Xiaozhe Yi; Junrong Chen; Guanghua He; Yihua Yin
Source:
Carbohydrate polymers 2017 v.162 pp. 35-41
ISSN:
0144-8617
Subject:
aqueous solutions; arginine; blood plasma; chitosan; crosslinking; dose response; encapsulation; in vitro studies; micelles; mixing; neoplasms; permeability; therapeutics; transmission electron microscopy
Abstract:
... In this study, a pH-induced morphological transition from micelles to vesicles for an amphiphilic photo cross-linkable biocopolymer (Az-NaCMCS), synthesized by mixing azidobenzaldehyde (Az) and an aqueous solution of carboxymethyl chitosan sodium salt (NaCMCS), was used for encapsulation of l-arginine deiminase (ADI). The aqueous solution of enzyme-loaded vesicles obtained was followed by UV-irrad ...
DOI:
10.1016/j.carbpol.2017.01.023

48. Cross-linking effect of polyphenolic extracts of Lepidium sativum seedcake on physicochemical properties of chitosan films

Author:
Deepak Kadam; S.S. Lele
Source:
International journal of biological macromolecules 2018 v.114 pp. 1240-1247
ISSN:
0141-8130
Subject:
Fourier transform infrared spectroscopy; Lepidium sativum; absorbance; active food packaging; antioxidant activity; chitosan; composite films; composite materials; crosslinking; crystal structure; dose response; ethanol; melting point; oils; oilseed cakes; polyphenols; scanning electron microscopy; tannins; tensile strength; thermography; water content
Abstract:
... Lepidium sativum seedcake phenolic extract (LSE), as compared to tannic acid (TA), was evaluated for its effect on film forming ability of chitosan. The films were investigated for their structural, mechanical, optical, thermal and in vitro antioxidant activity release profile. At 5% (v/v of film-forming solution), LSE led to improved 32.2% of tensile strength and 109% elongation, compared to the ...
DOI:
10.1016/j.ijbiomac.2018.04.018

49. Data supporting regulating temporospatial dynamics of morphogen for structure formation of the lacrimal gland by chitosan biomaterials

Author:
Ya-Chuan Hsiao; Tsung-Lin Yang
Source:
Data in Brief 2017 v.10 pp. 108-115
ISSN:
2352-3409
Subject:
biocompatible materials; chitosan; data collection; dose response; epithelium; hepatocyte growth factor; lacrimal apparatus; mitogen-activated protein kinase; models; morphogenesis; non-specific serine/threonine protein kinase; phosphorylation; secretion
Abstract:
... The lacrimal gland is responsible for tear synthesis and secretion, and is derived from the epithelia of ocular surface and generated by branching morphogenesis. The dataset presented in this article is to support the research results of the effect of chitosan biomaterials on facilitating the structure formation of the lacrimal gland by regulating temporospatial dynamics of morphogen. The embryoni ...
DOI:
10.1016/j.dib.2016.11.042

50. Delivery of rosiglitazone from an injectable triple interpenetrating network hydrogel composed of naturally derived materials

Author:
Hanwei Zhang; Aisha Qadeer; Dennis Mynarcik; Weiliam Chen
Source:
Biomaterials 2011 v.32 no.3 pp. 890-898
ISSN:
0142-9612
Subject:
animal models; biodegradability; byproducts; cell culture; chitosan; cytotoxicity; dextran; dose response; drugs; fibroblasts; hydrocolloids; inflammation; necrosis; tissue repair
Abstract:
... An in situ gelable and biodegradable triple-interpenetrating network (3XN) hydrogel, completely devoid of potentially cytotoxic extraneous small molecule crosslinkers, is formulated from partially oxidized dextran (Odex), teleostean and N-carboxyethyl chitosan (CEC). Both the rheological profile and mechanical strength of the 3XN hydrogel approximate the combined characteristics of the three indiv ...
DOI:
10.1016/j.biomaterials.2010.09.053
PubMed:
20947157
PubMed Central:
PMC3013076

51. Design and development of a workflow for microbial spray formulations including decision criteria

Author:
Ana Bejarano; Ursula Sauer; Claudia Preininger
Source:
Applied microbiology and biotechnology 2017 v.101 no.19 pp. 7335-7346
ISSN:
0175-7598
Subject:
Gram-negative bacteria; additives; adhesion; biocompatibility; castor oil; cell viability; chitosan; contact angle; corn; decision making; dose response; endophytes; foliar spraying; gelatin; glycerol; hydrophobicity; juveniles; leaves; microbial growth; monitoring; phytotoxicity; plant protection; polyethylene; researchers; rhamnolipids; saponins; surfactants; talc; thickeners; waxes; xanthan gum
Abstract:
... Herein, we present a workflow for the development of talc-based microbial inoculants for foliar spray consisting of four steps. These include together with decision-making criteria (1) the selection of additives based on their capability to wet juvenile maize leaves, (2) their adhesion on the plant, (3) their interaction with the biological systems, and (4) the choice of thickener for good dispers ...
DOI:
10.1007/s00253-017-8447-6

52. Development and biological evaluation of protective effect of kidney targeted N-acetylated chitosan nanoparticles containing thymoquinone for the treatment of DNA damage in cyclophosphamide-induced haemorrhagic cystitis

Author:
Chaitali Prajapati; Yogeeta O. Agrawal; Vinit V. Agnihotri; Umesh B. Mahajan; Kalpesh R. Patil; Dipak D. Patil; Chandragouda R. Patil
Source:
International journal of biological macromolecules 2022 v.214 pp. 391-401
ISSN:
0141-8130
Subject:
DNA; DNA damage; Nigella sativa; anti-inflammatory activity; biological assessment; bladder; chitosan; cyclophosphamide; cystitis; cytokines; dose response; epithelium; essential oils; fluorescein; freeze drying; gelation; half life; hematuria; histology; intravenous injection; isothiocyanates; kidneys; pain; particle size; pharmacokinetics; protective effect; thymoquinone; toxicity; zeta potential
Abstract:
... Thymoquinone (TQ), the most prominent constituent of Nigella sativa seeds, essential oil, is reported to possess an organ protective effect via Nrf2 expression and activation of Phase-II antioxidant enzymes. Haemorrhagic cystitis is the sudden onset of haematuria combined with bladder pain and irritable bladder symptoms are the known toxic effects of cyclophosphamide (CYP) chemotherapy. The object ...
DOI:
10.1016/j.ijbiomac.2022.06.070

53. Development of a photoresponsive chitosan conjugated prodrug nano-carrier for controlled delivery of antitumor drug 5-fluorouracil

Author:
Himali Horo; Soumi Das; Bishnupada Mandal; Lal Mohan Kundu
Source:
International journal of biological macromolecules 2019 v.121 pp. 1070-1076
ISSN:
0141-8130
Subject:
adverse effects; chemical bonding; chitosan; dimethyl sulfoxide; dose response; fluorouracil; gelation; hydrogels; illicit drugs; models; molecular weight; nanocarriers; nanoparticles; polymers; ultraviolet radiation; water solubility
Abstract:
... Controlled drug delivery offers improved therapeutic efficacy of the drugs while minimizing side effects. Biocompatible polymers and nanomaterials have emerged as effective carriers for the controlled delivery of drugs. We have synthesized a prodrug of 5-fluorouracil (5FU) covalently conjugated to low molecular weight chitosan (LMWC) via a photocleavable linker. The conjugate was designed to be cl ...
DOI:
10.1016/j.ijbiomac.2018.10.095

54. Dietary chitosan affects metabolism of arachidonic acid in weaned piglets

Author:
J.-L. Li; Y.-Q. Xu; B.-L. Shi; D.-S. Sun; S.-M. Yan; X.-Y. Guo
Source:
Czech Journal of Animal Science v.62 no.2 pp. 58-66
ISSN:
1212-1819
Subject:
Duroc; animal science; arachidonic acid; blood serum; chitosan; diet; dose response; duodenum; gene expression; immune response; jejunum; landraces; prostaglandin synthase; prostaglandins
Abstract:
... The effects of chitosan on immune function via arachidonic acid (AA) pathway in weaned piglets were investigated. A total of 180 piglets (Duroc × Yorkshire × Landrace) were randomly assigned to 5 dietary treatments and fed a basal diet supplemented with 0 (control), 100, 500, 1000, and 2000 mg chitosan/kg feed, respectively. Results showed that serum AA, prostaglandin E2 (PGE2), and leukotriene B4 ...
DOI:
10.17221/39/2016-cjas

55. Dietary chitosan oligosaccharides improves health status in broilers for safe poultry meat production

Author:
Ummay Ayman; Latifa Akter; Rafiqul Islam; Sonali Bhakta; Md. Asabur Rahman; Mohammad Rafiqul Islam; Nasrin Sultana; Arman Sharif; Mir Rubayet Jahan; Md. Shahidur Rahman; Ziaul Haque
Source:
Annals of agricultural science 2022 v.67 no.1 pp. 90-98
ISSN:
0570-1783
Subject:
agricultural sciences; albumins; blood glucose; blood proteins; blood serum; body weight changes; cecum; chitosan; creatinine; diet; dose response; duodenum; feed additives; globulins; glucose; growth performance; health status; high density lipoprotein cholesterol; kidneys; liver; meat production; oligosaccharides; poultry health; poultry industry; poultry meat; poultry production; surface area; triacylglycerols; very low density lipoprotein; villi
Abstract:
... Feed additives are routinely used for improving poultry health and production worldwide. Chitosan oligosaccharides (COS) is a relatively new feed additive that is a derivative of chitosan, a non-toxic linear polysaccharide with many biological functions. To investigate the efficacy of COS on gut morphology and serum biochemical profile (lipid, protein, glucose, creatinine and enzymes), a total of ...
DOI:
10.1016/j.aoas.2022.05.003

56. Dietary oligochitosan supplementation enhances immune status of broilers

Author:
Huang, R.L.; Deng, Z.Y.; Yang, C.B.; Yin, Y.L.; Xie, M.Y.; Wu, G.Y.; Li, T.J.; Li, L.L.; Tang, Z.R.; Kang, P.
Source:
Journal of the science of food and agriculture 2007 v.87 no.1 pp. 153-159
ISSN:
0022-5142
Subject:
broiler chickens; animal nutrition; dose response; growth and development; poultry feeding; experimental diets; chitosan; chicks; immunoglobulins; animal organs; prebiotics; oligosaccharides; immune system; immune response; feed supplements
Abstract:
... Oligochitosan (COS) is a type of prebiotic, which favourably alters the intestinal microflora balance, inhibits the growth of harmful bacteria, promotes good digestion and boosts immune function. The effect of dietary COS supplementation on immune function in broilers was assessed by feeding graded levels (0, 50, 100, 150 mg kg⁻¹) of COS. Two thousand four hundred male commercial Avian broilers (1 ...
DOI:
10.1002/jsfa.2694

57. Differential induction of lipoxygenase isoforms in wheat upon treatment with rust fungus elicitor, chitin oligosaccharides, chitosan, and methyl jasmonate

Author:
Bohland, C.; Balkenhohl, T.; Loers, G.; Feussner, I.; Grambow, H.J.
Source:
Plant physiology 1997 v.114 no.2 pp. 679-685
ISSN:
0032-0889
Subject:
protein synthesis; dose response; chitosan; seedlings; jasmonic acid; linoleate 13S-lipoxygenase; Puccinia graminis; Triticum aestivum; leaves; plant pathogenic fungi; oligosaccharides; chitin; enzyme activity; isozymes; protein composition
Abstract:
... A glycopeptide elicitor prepared from germ tubes of the rust fungus Puccinia graminis Pers. f. sp. tritici Erikss. & Henn (Pgt),as well as chitin oligosaccharides, chitosan, and methyl jasmonate (MJ) stimulated lipoxygenase (LOX) activity (E.C. 1.13.11.12) in wheat (Triticum aestivum) leaves. Immunoblot analysis using anti-LOX antibodies revealed the induction of 92- and 103-kD LOX species after P ...

58. Diphtheria toxoid and N-trimethyl chitosan layer-by-layer coated pH-sensitive microneedles induce potent immune responses upon dermal vaccination in mice

Author:
Pim Schipper; Koen van der Maaden; Vincent Groeneveld; Mitchel Ruigrok; Stefan Romeijn; Sven Uleman; Cees Oomens; Gideon Kersten; Wim Jiskoot; Joke Bouwstra
Source:
Journal of Controlled Release 2017 pp. -
ISSN:
0168-3659
Subject:
adjuvants; aluminum phosphate; antigens; chitosan; coatings; dose response; immune response; median effective concentration; mice; surface area; vaccination
Abstract:
... Dermal immunization using antigen-coated microneedle arrays is a promising vaccination strategy. However, reduction of microneedle sharpness and the available surface area for antigen coating is a limiting factor. To overcome these obstacles, a layer-by-layer coating approach can be applied onto pH-sensitive microneedles. Following this approach, pH-sensitive microneedle arrays (positively charged ...
DOI:
10.1016/j.jconrel.2017.07.017

59. Dose response of chitosan on nutrient digestibility, blood metabolites and lactation performance in holstein dairy cows

Author:
R.D. Mingoti; J.E. Freitas; J.R. Gandra; R. Gardinal; G.D. Calomeni; R.V. Barletta; T.H.A. Vendramini; P.G. Paiva; F.P. Rennó
Source:
Livestock science 2016 v.187 pp. 35-39
ISSN:
1871-1413
Subject:
Holstein; anti-infective properties; biodegradability; biopolymers; blood; body weight; chitosan; crude protein; dairy cows; data collection; diet; digestibility; dose response; dry matter intake; excretion; fatty acid composition; fatty acids; humans; industry; lactation; metabolites; milk; milk fatty acids; milk yield; neutral detergent fiber; nitrogen; nitrogen balance; organic matter; urea nitrogen; veterinary medicine
Abstract:
... Chitosan (CHI), a non-toxic and biodegradable biopolymer has been successfully used in the food, human and veterinary medicine industries, especially because of its antimicrobial properties. This study aimed to investigate the effects of CHI on dry matter intake (DMI), nutrient digestibility, blood metabolites, milk yield and composition, and milk fatty acids profile of lactating dairy cows. Sixte ...
DOI:
10.1016/j.livsci.2016.02.008

60. Dose-response effects of chitosans on in vitro rumen digestion and fermentation of mixtures differing in forage-to-concentrate ratios

Author:
Goiri, I.; Oregui, L.M.; Garcia-Rodriguez, A.
Source:
Animal feed science and technology 2009 v.151 no.3-4 pp. 215-227
ISSN:
0377-8401
Subject:
antimicrobial properties; ruminant nutrition; in vitro digestion; dose response; forage composition; volatile fatty acids; chitosan; biopolymers; feed additives; rumen fermentation; feed concentrates; mixtures
Abstract:
... The in vitro gas production technique was used to study the dose-response effects of three chitosans on rumen fermentation of three mixtures differing in their forage-to-concentrate ratio (80:20, 50:50 and 20:80). Four concentrations (0, 325, 750 and 1500mg/l of culture fluid) for each chitosan (CHI1, CHI2, and CHI3) were incubated for 24h in diluted ruminal fluid with three different mixtures. Sa ...
DOI:
10.1016/j.anifeedsci.2009.01.016

61. Dual effect of selenium loaded chitosan nanoparticles on growth, antioxidant, immune related genes expression, transcriptomics modulation of caspase 1, cytochrome P450 and heat shock protein and Aeromonas hydrophila resistance of Nile Tilapia (Oreochromis niloticus)

Author:
Doaa Ibrahim; Ahmed N.F. Neamat-Allah; Seham M. Ibrahim; Hemmat M. Eissa; M.M. Fawzey; Doaa I.A. Mostafa; Shaimaa A. Abd El-Kader; S.I. Khater; Safaa I. Khater
Source:
Fish & shellfish immunology 2021 v.110 pp. 91-99
ISSN:
1050-4648
Subject:
Aeromonas hydrophila; Oreochromis niloticus; antioxidants; apoptosis; aquaculture; blood serum; caspase-1; catalase; chitosan; complement; cytochrome P-450; dose response; feed conversion; fish; genes; glutathione peroxidase; heat shock proteins; immunoglobulins; interleukin-10; interleukin-8; lysozyme; malondialdehyde; myeloperoxidase; myostatin; nanocomposites; selenium; shellfish; superoxide dismutase; survival rate; transcriptomics; water treatment
Abstract:
... Nowadays there is a great attention for nanotechnology in aquaculture production. It has an efficient role in nutrients and drugs delivery, ponds sterilization, water treatment and aquatic diseases reduction. Till now, there is no available data on impact of selenite-loaded chitosan nanoparticles (SeChNPs) on Nile tilapia. Hence, the current study investigated the effects of selenite-loaded chitos ...
DOI:
10.1016/j.fsi.2021.01.003

62. Edible Films Made of Dried Olive Leaf Extract and Chitosan: Characterization and Applications

Author:
Michela Famiglietti; Alessandro Savastano; Rosa Gaglione; Angela Arciello; Daniele Naviglio; Loredana Mariniello
Source:
Foods 2022 v.11 no.14 pp. -
ISSN:
2304-8158
Subject:
Olea europaea; antifungal properties; antioxidant activity; bioplastics; chitosan; dose response; food preservation; human health; leaf extracts; olives; paper; polyphenols; shelf life
Abstract:
... Nowadays a possible strategy in food preservation consists of the use of active and functional packaging to improve safety and ensure a longer shelf life of food products. Many studies refer to chitosan-based films because of the already-known chitosan (CH) antibacterial and antifungal activity. In this work, we developed CH-based films containing Dried Olive Leaf Extract (DOLE) obtained by Navigl ...
DOI:
10.3390/foods11142078

63. Effects of chitosan nanoparticle supplementation on growth performance, humoral immunity, gut microbiota and immune responses after lipopolysaccharide challenge in weaned pigs

Author:
Yinglei Xu; Huiling Mao; Caimei Yang; Huahua Du; Haifeng Wang; Jue Tu
Source:
Journal of animal physiology and animal nutrition 2020 v.104 no.2 pp. 597-605
ISSN:
0931-2439
Subject:
Escherichia coli; average daily gain; chitosan; cortisol; diarrhea; dietary supplements; dose response; ecology; feed additives; feed intake; growth performance; humoral immunity; immune response; immunoglobulin G; immunoglobulin M; interleukin-1beta; interleukin-6; intestinal microorganisms; intestines; lipopolysaccharides; nanoparticles; pathogens; piglets; prostaglandins; sodium chloride; tumor necrosis factor-alpha
Abstract:
... In this study, we aimed to determine the effects of dietary supplementation with chitosan nanoparticles (CNP) on growth performance, immune status, gut microbiota and immune responses after lipopolysaccharide challenge in weaned pigs. A total of 144 piglets were assigned to four groups receiving different dietary treatments, including basal diets supplemented with 0, 100, 200 and 400 mg/kg CNP fed ...
DOI:
10.1111/jpn.13283

64. Effects of chitosan on nitric oxide production and inducible nitric oxide synthase activity and mRNA expression in weaned piglets

Author:
J. Li; B. Shi; S. Yan; L. Jin; Y. Guo; T. Li
Source:
Czech Journal of Animal Science v.60 no.8 pp. 359-366
ISSN:
1212-1819
Subject:
animal science; blood serum; chitosan; diet; dose response; duodenum; gene expression; ileum; inducible nitric oxide synthase; jejunum; lipopolysaccharides; nitric oxide; piglets
Abstract:
... The effects of chitosan on nitric oxide (NO) production and inducible nitric oxide synthase (iNOS) activity and gene expression in vivo or vitro were investigated in weaned piglets. In vivo, 180 weaned piglets were assigned to five dietary treatments with six replicates. The piglets were fed on a basal diet supplemented with 0 (control), 100, 500, 1000, and 2000 mg chitosan/kg feed, respectively. ...
DOI:
10.17221/8405-cjas

65. Effects of chitosan on the physicochemical properties, in vitro starch digestibility, antimicrobial potentials, and antioxidant activities of purple highland barley noodles

Author:
Yongzhu Zhang; Liqing Yin; Hafiz Abdul Rasheed; Xiudong Xia; Mekonen Tekliye; Zhiyu Li; Jianzhong Li; Mingsheng Dong
Source:
Lebensmittel-Wissenschaft + Technologie 2020 v.132 pp. 109802
ISSN:
0023-6438
Subject:
antioxidants; barley; chitosan; digestible carbohydrates; dose response; glycemic index; hydrolysis; starch; texture; water holding capacity
Abstract:
... Chitosan is a natural additive widely used in food processing due to its functional properties, but few messages are available about the direct effects of chitosan on the quality of purple highland barley noodles (PHBN). Samples with 0.25%–2% (w/w) of chitosan addition were assessed in this study. Results indicated that the texture and water-holding capacity (WHC) of PHBN were significantly increa ...
DOI:
10.1016/j.lwt.2020.109802

66. Effects of quaternization and PEGylation on the biocompatibility, enzymatic degradability and antioxidant activity of chitosan derivatives

Author:
Liming Cui; Cui Tang; Chunhua Yin
Source:
Carbohydrate polymers 2012 v.87 no.4 pp. 2505-2511
ISSN:
0144-8617
Subject:
adsorption; antioxidant activity; biocompatibility; biodegradability; chemical bonding; chitosan; composite polymers; contact angle; cytotoxicity; dose response; ethylene glycol; hydrophilicity; lipid peroxidation; molecular weight; reducing sugars
Abstract:
... Chitosan-N-trimethylaminoethylmethacrylate chloride (CS-TM) copolymers with different quaternization degrees (DQ, 30 and 50%) were synthesized and further modified with methoxypoly(ethylene glycol) (mPEG) of different molecular weights (MW, 2 and 5kDa). The hydrophilicity of the resulting copolymers was significantly increased as evidenced by decreased contact angles. PEGylation with higher mPEG M ...
DOI:
10.1016/j.carbpol.2011.11.030

67. Efficacy of Coagulants and Ballast Compounds in Removal of Cyanobacteria (Microcystis) from Water of the Tropical Lagoon Jacarepaguá (Rio de Janeiro, Brazil)

Author:
Leonardo de Magalhães; Natália Pessoa Noyma; Luciana Lima Furtado; Maíra Mucci; Frank van Oosterhout; Vera L. M. Huszar; Marcelo Manzi Marinho; Miquel Lürling
Source:
Estuaries and coasts 2017 v.40 no.1 pp. 121-133
ISSN:
1559-2723
Subject:
Microcystis; aluminum; chitosan; chlorides; coagulants; coastal water; dose response; eutrophication; flocks; sediments; shrimp; soil; toxicity; water quality; Brazil
Abstract:
... Eutrophication is considered the most important water quality problem in freshwaters and coastal waters worldwide promoting frequent occurrence of blooms of potentially toxic cyanobacteria. Removal of cyanobacteria from the water column using a combination of coagulant and ballast is a promising technique for mitigation and an alternative to the use of algaecides. In laboratory, we tested experime ...
DOI:
10.1007/s12237-016-0125-x

68. Elicitor Actions of N-Acetylchitooligosaccharides and Laminarioligosaccharides for Chitinase and l-Phenylalanine Ammonia-lyase Induction in Rice Suspension Culture

Author:
Hiroshi Inui; Yasuhiro Yamaguchi; Shigehiro Hirano
Source:
Bioscience, biotechnology, and biochemistry 1997 v.61 no.6 pp. 975-978
ISSN:
1347-6947
Subject:
biotechnology; chitin; chitinase; chitosan; dose response; elicitors; oligosaccharides; phenylalanine; rice
Abstract:
... When a series of chitin oligosaccharides was added into a rice suspension culture, N-acetylchito- hexaose, N-acetylchitopentaose, and N-acetylchitotetraose caused an increase in extracellular chitinase activity, mainly due to induction of a class III chitinase. In the case of N-acetylchitohexaose, a substantial increase in the chitinase activity was observed at a concentration higher than 0.01 μg/ ...
DOI:
10.1271/bbb.61.975

69. Ellagic acid encapsulated chitosan nanoparticles for drug delivery system in human oral cancer cell line (KB)

Author:
V. Arulmozhi; K. Pandian; S. Mirunalini
Source:
Colloids and Surfaces B: Biointerfaces 2013 v.110 pp. 313-320
ISSN:
0927-7765
Subject:
DNA fragmentation; antineoplastic agents; chitosan; colloids; cytotoxicity; dose response; drug delivery systems; ellagic acid; gelation; humans; inhibitory concentration 50; models; mouth neoplasms; nanoparticles; particle size; water solubility
Abstract:
... Ellagic acid (EA), a naturally occurring polyphenolic compound is well documented for its anticancer property in numerous pre-clinical models. The properties like poor water solubility and limited oral bio-availability of ellagic acid has hampered its clinical applications. The present study, reports the preparation of ellagic acid encapsulated chitosan nanoparticles (EA@CS-NP) by ionic gelation m ...
DOI:
10.1016/j.colsurfb.2013.03.039

70. Enhanced cytotoxic and apoptotic potential in hepatic carcinoma cells of chitosan nanoparticles loaded with ginsenoside compound K

Author:
Jianmei Zhang; Yijun Wang; Yunyao Jiang; Tingwu Liu; Yanyan Luo; Enjie Diao; Yufeng Cao; Liang Chen; Liang Zhang; Qian Gu; Jinyi Zhou; Fengting Sun; Wancai Zheng; Jianxun Liu; Xueqin Li; Weicheng Hu
Source:
Carbohydrate polymers 2018 v.198 pp. 537-545
ISSN:
0144-8617
Subject:
antineoplastic activity; apoptosis; chitosan; cytotoxicity; dose response; drug carriers; drug therapy; drugs; fluorescence; human cell lines; humans; image analysis; inhibitory concentration 50; liver neoplasms; nanoparticles; neoplasm cells; surfactants; water solubility
Abstract:
... Ginsenoside compound K (CK) has been shown to exhibit anticancer properties. In this study, chitosan nanoparticles loaded with ginsenoside compound K (CK-NPs) were prepared as a delivery system using a self-assembly technique with amphipathic deoxycholic acid-O carboxymethyl chitosan as the carrier, which improved the water solubility of CK. By evaluating drug loading, entrapment efficiency, and i ...
DOI:
10.1016/j.carbpol.2018.06.121

71. Extraction and recovery response of Penaeus indicus chitosan against Aeromonas hydrophila Ah17 infected snakehead murrel Channa striata [Erratum: Apr. 2020, v.28(2), p.867]

Author:
Vignesh Samayanpaulraj; Vijay Velu; Muthukumar Sivaramapillai; Krishnaveni Govindaraj; Ramesh Uthandakalaipandiyan
Source:
Aquaculture international 2020 v.28 no.2 pp. 587-602
ISSN:
0967-6120
Subject:
Aeromonas hydrophila; Channa striata; Fenneropenaeus indicus; Fourier transform infrared spectroscopy; Portunus pelagicus; binding capacity; biocompatible materials; blood proteins; chitosan; crabs; disease control; dose response; exoskeleton; fish diseases; freshwater fish; gene expression; gene expression regulation; genes; immune system; in vivo studies; interleukin-8; liver; medicinal properties; physicochemical properties; seafood waste; shrimp; transforming growth factor beta; value added
Abstract:
... Chitosan is one of the most versatile value-added biomaterial obtained from the shell waste of crustaceans. The present study focused on chitosan extraction from the exoskeleton of crab, Portunus pelagicus (P. pelagicus), and shrimp, Penaeus indicus (P. indicus); further therapeutic properties were evaluated against the bacterial fish pathogen Aeromonas hydrophila Ah17 (A. hydrophila Ah17) in econ ...
DOI:
10.1007/s10499-019-00481-4

72. Extraction, characterization, and nematicidal activity of chitin and chitosan derived from shrimp shell wastes

Author:
Mohamed A. Radwan; Samia A. A. Farrag; Mahmoud M. Abu-Elamayem; Nabila S. Ahmed
Source:
Biology and fertility of soils 2012 v.48 no.4 pp. 463-468
ISSN:
0178-2762
Subject:
Fourier transform infrared spectroscopy; Meloidogyne incognita; chitin; chitosan; dose response; greenhouses; nematicidal properties; nematicides; nuclear magnetic resonance spectroscopy; oxamyl; phytotoxicity; root-knot nematodes; shrimp shells; soil; tomatoes
Abstract:
... Chitin has been chemically extracted from the Egyptian shrimp shell waste. The obtained chitin was transformed into the more soluble chitosan. Chitin and chitosan were characterized using Fourier-transform infrared spectroscopy and proton nuclear magnetic resonance spectrometry. These products were also characterized by their nematicidal potential against the root-knot nematode, Meloidogyne incogn ...
DOI:
10.1007/s00374-011-0632-7

73. Fabrication of chitosan-bis (4-formyl-2 methoxy phenyl carbonate) Schiff base nanoparticles and evaluation of their antioxidant and anticancer properties

Author:
P. Thyriyalakshmi; K. V. Radha
Source:
Molecular biology reports 2019 v.46 no.4 pp. 4333-4347
ISSN:
0301-4851
Subject:
X-ray diffraction; antineoplastic activity; antioxidants; carbon; carbonates; cell lines; chitosan; crosslinking; cytotoxicity; dose response; drugs; hydrolysis; moieties; nanoparticles; neoplasms; nuclear magnetic resonance spectroscopy; schiff bases; stable isotopes; therapeutics; thermal stability; thermogravimetry; transmission electron microscopy; vanillin
Abstract:
... The present study details on the mechanism of synthesis of bis (4-formyl-2 methoxy phenyl carbonate), using two green reagents dimethyl carbonate and vanillin for application as therapeutic agent. The synthesized FMPC was identified from the ¹³C nuclear magnetic resonance spectra. The novel modified Schiff base nanoparticles resulted from the crosslinking of FMPC with chitosan were confirmed by cr ...
DOI:
10.1007/s11033-019-04887-4

74. Facile synthesis and antibacterial activity of geraniol conjugated chitosan oligosaccharide derivatives

Author:
Ran Bi; Lin Yue; Sobia Niazi; Imran Mahmood Khan; Dan Sun; Bin Wang; Zhouping Wang; Qixing Jiang; Wenshui Xia
Source:
Carbohydrate polymers 2021 v.251 pp. 117099
ISSN:
0144-8617
Subject:
Escherichia coli; Staphylococcus aureus; antibacterial properties; chitosan; dose response; food industry; geraniol; oligosaccharides
Abstract:
... A new chitosan oligosaccharide derivative (COS-N-Ger), based on geraniol (Ger) modificated onto the NH₂ position of chitosan oligosaccharide (COS) via a facile method, was prepared and employed to evaluate in vitro antibacterial activity. The structures of COS-N-Ger derivatives were confirmed by FT-IR, ¹H, ¹³C NMR, and elemental analysis. The characterization results showed successful synthesis of ...
DOI:
10.1016/j.carbpol.2020.117099

75. Ferulago campestris Essential Oil as Active Ingredient in Chitosan Seed-Coating: Chemical Analyses, Allelopathic Effects, and Protective Activity against the Common Bean Pest Acanthoscelides obtectus

Author:
Roberta Ascrizzi; Guido Flamini; Stefano Bedini; Camilla Tani; Paolo Giannotti; Tiziana Lombardi; Barbara Conti; Daniele Fraternale
Source:
Agronomy 2021 v.11 no.8 pp. -
ISSN:
2073-4395
Subject:
Acanthoscelides obtectus; Papaver rhoeas; Phaseolus vulgaris; Poa annua; Setaria verticillata; Taraxacum; active ingredients; agronomy; beans; chitosan; dose response; essential oils; hydrodistillation; hydrogen peroxide; lipid peroxidation; myrcene; toxicity; weeds; Europe
Abstract:
... Ferulago campestris is an aromatic plant, distributed in Mediterranean Europe, and a source of essential oils (EOs) regarded as promising alternatives to synthetic herbicides and pesticides. F. campestris EO, hydrodistilled and analyzed, was tested for its antigerminative activity and for its effect on radicle elongation, hydrogen peroxide concentration, and lipid peroxidation on four infesting we ...
DOI:
10.3390/agronomy11081578

76. Fungal enzyme-mediated synthesis of chitosan nanoparticles and its biocompatibility, antioxidant and bactericidal properties

Author:
Kandasamy Saravanakumar; Ramachandran Chelliah; Davoodbasha MubarakAli; Elango Jeevithan; Deog-Hwan Oh; Kandasamy Kathiresan; Myeong-Hyeon Wang
Source:
International journal of biological macromolecules 2018 pp. -
ISSN:
0141-8130
Subject:
Fourier transform infrared spectroscopy; Salmonella Typhimurium; Staphylococcus aureus; Trichoderma harzianum; acridine orange; antibacterial properties; antioxidant activity; antioxidants; bacteria; biocompatibility; cell viability; chitosan; cytotoxicity; dose response; ethidium; fibroblasts; fungi; mice; moieties; nanoparticles; pH; particle size; solubility; staining; transmission electron microscopy; ultraviolet-visible spectroscopy
Abstract:
... This paper reports the synthesis of chitosan nanoparticles (T-CSNPs) using the fungal enzyme of Trichoderma harzianum and its biocompatible, antioxidant and bactericidal properties. This T-CSNPs synthesis was confirmed by strong plasma (Plasmon) resonance peak at 280 nm using UV–Vis spectrophotometer. T-CSNPs were of spherical shape, as evident by field emission transmission electron microscopic ( ...
DOI:
10.1016/j.ijbiomac.2018.06.198

77. Hepatitis B-surface antigen (HBsAg) vaccine fabricated chitosan-polyethylene glycol nanocomposite (HBsAg-CS-PEG- NC) preparation, immunogenicity, controlled release pattern, biocompatibility or non-target toxicity

Author:
Karthick Raja Namasivayam S; AN Nishanth; Arvind Bharani R S; Kiran Nivedh; Nawaz Hussain Syed; Rosario Samuel R
Source:
International journal of biological macromolecules 2020 v.144 pp. 978-994
ISSN:
0141-8130
Subject:
Brassica nigra; Fourier transform infrared spectroscopy; T-lymphocytes; Vigna mungo; Vigna radiata; animal models; antioxidant enzymes; atomic force microscopy; biocompatibility; blood proteins; chitosan; dose response; erythrocytes; gelation; germination; hemolysis; hepatitis; hepatitis B antigens; immunogenicity; macrophages; medicine; mice; monocytes; mortality; nanocomposites; nanomaterials; phagocytosis; phytotoxicity; polyethylene glycol; protein composition; roughness; seedlings; seeds; subacute toxicity; vaccines
Abstract:
... Antigen delivery framework utilising polymer-based nanomaterial is broadly used in biomedicine because of their high efficacy, antigenicity and biocompatibility. In this study, hepatitis B surface antigen fabricated chitosan-polyethylene glycol nanocomposite (HBsAg-CS-PEG NC) was prepared by in situ ionic gelation method which brought about highly stable nanoformulation that was characterised by e ...
DOI:
10.1016/j.ijbiomac.2019.09.175

78. Hyaluronic acid and chondrogenesis of murine bone marrow mesenchymal stem cells in chitosan sponges

Author:
Schwartz, Zeev; Griffon, Dominique J.; Fredericks, L. Page; Lee, Hae-Beom; Weng, Hsin-Yi
Source:
American journal of veterinary research 2011 v.72 no.1 pp. 42-50
ISSN:
0002-9645
Subject:
spatial distribution; chondrogenesis; scanning electron microscopy; cell differentiation; cell adhesion; dose response; fluorescence; DNA; bone marrow; molecular weight; chitosan; collagen; mice; stem cells; in vitro studies; hyaluronic acid; culture media; viability; dosage; chondrocytes
DOI:
10.2460/ajvr.72.1.42

79. Hyaluronic acid/chitosan nanoparticles for delivery of curcuminoid and its in vitro evaluation in glioma cells

Author:
Liu Yang; Shiya Gao; Sajid Asghar; Guihua Liu; Jue Song; Xuan Wang; Qineng Ping; Can Zhang; Yanyu Xiao
Source:
International journal of biological macromolecules 2015 v.72 pp. 1391-1401
ISSN:
0141-8130
Subject:
X-ray diffraction; brain; chitosan; cytotoxicity; dose response; drugs; electrolytes; encapsulation; endocytosis; hyaluronic acid; in vitro studies; ionic strength; nanoparticles; pH; temperature; therapeutics
Abstract:
... The aim of this work was to evaluate the potential of polyelectrolyte complex nanoparticles (PENPs) based on hyaluronic acid/chitosan (HA/CS) as carriers for water-insoluble curcuminoid (CUR) and explore in vitro performance against brain glioma cells. PENPs were observed to be affected by the order of addition, mass ratios and initial concentrations of the HA/CS, pH and ionic strength. PENPs rema ...
DOI:
10.1016/j.ijbiomac.2014.10.039

80. Hydrolysis of a Chitosan-induced Milk Aggregate by Pepsin, Trypsin and Pancreatic Lipase

Author:
Salvador F. AUSAR; Carlos A. LANDA; Ismael D. BIANCO; Leonardo F. CASTAGNA; Dante M. BELTRAMO
Source:
Bioscience, biotechnology, and biochemistry 2001 v.65 no.11 pp. 2412-2418
ISSN:
1347-6947
Subject:
absorbance; biotechnology; casein; chitosan; coagulation; dose response; hydrolysis; intestines; lipemic effect; micelles; milk fat; molecular weight; pepsin; peptides; triacylglycerol lipase; trypsin; whole milk
Abstract:
... The addition of chitosan to whole milk results in dose dependent destabilization and coagulation of the casein micelles and milk fat. The present study evaluates how the presence of chitosan could affect the hydrolysis of this chitosan-induced aggregate by different gastrointestinal proteases (pepsin and trypsin) and by pancreatic lipase. The chitosan-milk aggregate was hydrolyzed by pepsin and tr ...
DOI:
10.1271/bbb.65.2412

81. Hydroxypropyltrimethyl ammonium chloride chitosan activates RAW 264.7 macrophages through the MAPK and JAK-STAT signaling pathways

Author:
Yue Yang; Ronge Xing; Song Liu; Yukun Qin; Kecheng Li; Huahua Yu; Pengcheng Li
Source:
Carbohydrate polymers 2019 v.205 pp. 401-409
ISSN:
0144-8617
Subject:
Western blotting; chitosan; dose response; flow cytometry; immunostimulants; interleukin-6; macrophages; mitogen-activated protein kinase; molecular weight; nitric oxide; non-specific protein-tyrosine kinase; phosphorylation; quaternary ammonium compounds; reverse transcriptase polymerase chain reaction; signal transduction; transactivators; tumor necrosis factor-alpha; water solubility
Abstract:
... Hydroxypropyltrimethyl ammonium chloride chitosan (HACC) is a water-soluble derivative of chitosan. To investigate the immunostimulatory effects of HACC, quaternized chitosans with different molecular weights were prepared and their effects on RAW 264.7 macrophages were compared. The results showed that HACC promoted nitric oxide (NO) production in a molecular weight- and dose-dependent manner. Lo ...
DOI:
10.1016/j.carbpol.2018.10.101

82. Hypoglycemic activity of withanolides and elicitated Withania somnifera

Author:
Jonathan Gorelick; Rivka Rosenberg; Avinoam Smotrich; Lumír Hanuš; Nirit Bernstein
Source:
Phytochemistry 2015 v.116 pp. 283-289
ISSN:
0031-9422
Subject:
Withania somnifera; adipocytes; animal models; chitosan; diabetes; dose response; elicitors; glucose; glycemic effect; insulin secretion; islets of Langerhans; leaf extracts; leaves; methyl salicylate; myotubes; osmotic pressure; patients; physiological state; India
Abstract:
... Withania somnifera, known in India as Asghawhanda, is used traditionally to treat many medical problems including diabetes and has demonstrated therapeutic activity in various animal models as well as in diabetic patients. While much of W. somnifera’s therapeutic activity is attributed to withanolides, their role in the anti-diabetic activity of W. somnifera has not been adequately studied. In the ...
DOI:
10.1016/j.phytochem.2015.02.029

83. Immunostimulatory effect of dietary chitosan nanoparticles on the performance of Nile tilapia, Oreochromis niloticus (L.)

Author:
Mohsen Abdel-Tawwab; Nashwa Abdel Razek; Azza M. Abdel-Rahman
Source:
Fish & shellfish immunology 2019 v.88 pp. 254-258
ISSN:
1050-4648
Subject:
Oreochromis niloticus; antioxidant activity; catalase; chitosan; dose response; enzyme activity; feed supplements; fish; fish culture; growth performance; immunostimulants; innate immunity; lysozyme; malondialdehyde; nanoparticles; respiratory burst; superoxide dismutase
Abstract:
... Feed supplements to fish are generally used to overcome any expected diseases and stressors and to sustain eco-friendly fish farming. One of these feed supplements is chitosan, which stimulated growth and immune properties for many aquatic organisms. It is expected that the nano-sized materials may have stronger immune activation in fish than the ordinary size. Therefore, the current study was con ...
DOI:
10.1016/j.fsi.2019.02.063

84. Improvement of artemisinin production by chitosan in hairy root cultures of Artemisia annua L

Author:
Putalun, Waraporn; Luealon, Wanwimon; De-Eknamkul, Wanchai; Tanaka, Hiroyuki; Shoyama, Yukihiro
Source:
Biotechnology letters 2007 v.29 no.7 pp. 1143-1146
ISSN:
0141-5492
Subject:
Artemisia annua; artemisinin; chitosan; dose response; methyl jasmonate; roots; yeast extract
Abstract:
... Artemisinin production by hairy roots of Artemisia annua L. was increased 6-fold to 1.8 μg mg-¹ dry wt over 6 days by adding 150 mg chitosan l-¹. The increase was dose-dependent. Similar treatment of hairy roots with methyl jasmonate (0.2 mM) or yeast extract (2 mg ml-¹) increased artemisinin production to 1.5 and 0.9 μg mg-¹ dry wt, respectively. ...
DOI:
10.1007/s10529-007-9368-8
PubMed:
17426924

85. In vitro and in vivo evaluation of curcumin loaded lauroyl sulphated chitosan for enhancing oral bioavailability

Author:
R. Shelma; Chandra P. Sharma
Source:
Carbohydrate polymers 2013 v.95 no.1 pp. 441-448
ISSN:
0144-8617
Subject:
antineoplastic agents; antioxidant activity; bioavailability; chitosan; curcumin; cytotoxicity; dose response; encapsulation; in vivo studies; oral administration; pharmacokinetics; rats; solubility
Abstract:
... Curcumin has been demonstrated as a potent anticancer agent but its clinical application has been limited by its poor aqueous solubility and bioavailability. Here we describe encapsulation of curcumin in the lauroyl sulphated chitosan with a view to improve its bioavailability. In vitro antioxidant activity of extract of curcumin loaded matrix was investigated and exhibited dose dependent radical ...
DOI:
10.1016/j.carbpol.2013.02.029

86. In vitro antifungal efficacy of Aspergillus niger ATCC 9642 chitosan-AgNPs composite against post-harvest disease of citrus fruits

Author:
H. Al-Sheikh; R. S. Yehia
Source:
Applied biochemistry and microbiology 2016 v.52 no.4 pp. 413-420
ISSN:
0003-6838
Subject:
Aspergillus niger; DNA damage; Fourier transform infrared spectroscopy; Penicillium digitatum; Penicillium italicum; chitosan; citrus fruits; correlation; dose response; fungi; markets; molecular weight; postharvest diseases; shrimp; spore germination; viscosity
Abstract:
... Green and blue mold postharvest diseases are the most vital negative components influencing the local market of citrus fruits. Citrus fruits were collected, and fungi were isolated. Among the fungal isolates identified, Penicillium digitatum and Penicillium italicum recorded the highest occurrence of 39.5 and 25.6%, respectively. In this work, we extracted chitosan from Aspergillum niger ATCC 9642 ...
DOI:
10.1134/S0003683816040177

87. In vitro assessment of the antimicrobial efficacy of chitosan nanoparticles against major fish pathogens and their cytotoxicity to fish cell lines

Author:
Fatma Ahmed; Faiza M. Soliman; Mohamed A. Adly; Hamdy A.M. Soliman; Mansour El‐Matbouli; Mona Saleh
Source:
Journal of fish diseases 2020 v.43 no.9 pp. 1049-1063
ISSN:
0140-7775
Subject:
Oomycetes; antibacterial properties; antibiotics; aquaculture; bacterial growth; cell lines; cell membranes; cell viability; chitosan; cytotoxicity; disease prevention; dose response; fish; in vitro studies; minimum inhibitory concentration; nanoparticles; pathogens; transmission electron microscopy
Abstract:
... Nanotechnology is an emerging avenue employed in disease prevention and treatment. This study evaluated the antimicrobial efficacy of chitosan nanoparticles (CSNPs) against major bacterial and oomycete fish pathogens in comparison with chitosan suspension. Initially, the minimum inhibitory concentrations (MIC, MIC₉₀) were determined and the per cent inhibition of bacterial growth was calculated. S ...
DOI:
10.1111/jfd.13212

88. In vitro effects of crab shell chitosan against mycelial growth of Botrytis sp., Penicillium sp. and Pilidiella granati

Author:
K. Munhuweyi; C. L. Lennox; J. C. Meitz-Hopkins; O. J. Caleb; G. O. Sigge; U. L. Opara
Source:
Acta horticulturae 2016 v. no.1144 pp. 403-408
ISSN:
0567-7572
Subject:
Botrytis; Penicillium; antifungal properties; chitosan; crabs; dose response; fludioxonil; median effective concentration; mycelium; pathogens; pomegranates
Abstract:
... The antifungal activities of crab shell chitosan and fludioxonil (registered postharvest fungicide) were evaluated in vitro against Botrytis sp., Penicillium sp. and Pilidiella granati isolated from pomegranate fruit. Mycelial growth of the pathogens was inhibited by both chitosan and fludioxonil in a dose-dependent manner, with complete inhibition at 10 and 0.01 mg mL-1, respectively. The concent ...
DOI:
10.17660/ActaHortic.2016.1144.60

89. In vitro elicitation, isolation, and characterization of conessine biomolecule from Holarrhena antidysenterica (L.) Wall. callus and its larvicidal activity against malaria vector, Anopheles stephensi Liston

Author:
Dinesh Kumar; Gaurav Kumar; Ram Das; Ravindra Kumar; Veena Agrawal
Source:
Environmental science and pollution research international 2018 v.25 no.7 pp. 6783-6796
ISSN:
0944-1344
Subject:
2,4-D; Anopheles stephensi; Fourier transform infrared spectroscopy; Holarrhena pubescens; Mesocyclops; arsenic oxide; bark; bioassays; callus; callus culture; casein hydrolysates; chitosan; copper sulfate; dose response; elicitors; explants; high performance liquid chromatography; indole butyric acid; insect vectors; larvicides; lead; lethal concentration 50; malaria; methanol; naphthaleneacetic acid; nitrates; nuclear magnetic resonance spectroscopy; phenylalanine; proline; sodium chloride; solvents; sucrose; tryptophan; tyrosine; yeast extract
Abstract:
... In vitro elicitation of an important compound conessine has been done in the bark-derived callus culture of Holarrhena antidysenterica (L.) Wall. employing different elicitors. For induction of callus, green bark explants excised from field-grown plants were cultured on MS medium augmented with different concentrations (0, 1, 2.5, 5, and 10 μM) of various growth regulators such as BA, IBA, NAA, an ...
DOI:
10.1007/s11356-017-1038-3

90. In vitro evaluation of combination of Trichoderma harzianum and chitosan for the control of sapstain fungi

Author:
Chittenden, Colleen; Singh, Tripti
Source:
Biological control 2009 v.50 no.3 pp. 262-266
ISSN:
1049-9644
Subject:
fungal antagonists; temporal variation; sapstain fungi; application rate; dose response; chitosan; Leptographium; postharvest diseases; hyphae; disease control; dosage; microbial growth; sawlogs; Sphaeropsis; spore germination; Trichoderma lixii; culture media; in vitro studies; biological control
Abstract:
... In vitro assays were undertaken to evaluate the control of two sapstain fungi, Leptographium procerum and Sphaeropsis sapinea by a combination of chitosan or chitosan oligomer and an albino strain of Trichoderma harzianum. Spore germination and hyphal growth of the test fungi were assessed on media amended with chitosan or chitosan oligomer with and without T. harzianum using either simultaneous i ...
DOI:
10.1016/j.biocontrol.2009.04.015

91. In vitro immuno-modulatory ability of tryptic caseinate hydrolysate affected by prior caseinate glycation using the Maillard reaction or transglutaminase

Author:
Jia Shi; Xin-Huai Zhao
Source:
Food and agricultural immunology 2017 v.28 no.6 pp. 1029-1045
ISSN:
0954-0105
Subject:
Maillard reaction; amino acids; caseinates; catalytic activity; chitosan; cytokines; dose response; glycation; hydrolysates; hydrolysis; lactose; macrophages; natural killer cells; protein-glutamine gamma-glutamyltransferase; secretion; splenocytes; trypsin
Abstract:
... Caseinate was glycated by lactose and oligochitosan via the Maillard reaction and transglutaminase catalysis to yield two glycated caseinates (GC-I and GC-II), followed by trypsin hydrolysis to generate GC-I hydrolysate and GC-II hydrolysate, respectively. In comparison with caseinate hydrolysate, only GC-I hydrolysate showed decreased His, Lys, Tyr, and Val contents. All three hydrolysates in dos ...
DOI:
10.1080/09540105.2017.1325842

92. In vitro screening of natural feed additives from crustaceans, diatoms, seaweeds and plant extracts to manipulate rumen fermentation

Author:
Alejandro Belanche; Eva Ramos‐Morales; C Jamie Newbold
Source:
Journal of the science of food and agriculture 2016 v.96 no.9 pp. 3069-3078
ISSN:
0022-5142
Subject:
Ascophyllum nodosum; Bacillariophyceae; Crustacea; Laminaria; acetates; ammonia; animals; anti-infective properties; bacteria; butyrates; chitosan; dose response; feed additives; fermentation; fruit extracts; macroalgae; mechanism of action; methane; methane production; microbial ecology; neem oil; propionic acid; rumen fermentation; rumen microorganisms; saponins; screening
Abstract:
... BACKGROUND: Eight natural products from animal, unicellular algae, brown seaweed and plant origins were chosen according to their theoretical antimicrobial activity: Diatomaceous earths (DE), insoluble chitosan (ICHI), soluble chitosan (CHI), seaweed meal (SWM), Ascophyllum nodosum (ASC), Laminaria digitata (LAM), neem oil (NOIL) and an ivy fruit extract rich in saponins (IVY). Dose–response incub ...
DOI:
10.1002/jsfa.7481

93. In vitro tumor suppression properties of blueberry extracts in liquid and encapsulated forms

Author:
Aslihan Kazan; Canan Sevimli-Gur; Ozlem Yesil-Celiktas; Nurhan Tugut Dunford
Source:
European food research & technology 2017 v.243 no.6 pp. 1057-1063
ISSN:
1438-2377
Subject:
acetone; adenocarcinoma; anthocyanins; blueberries; breasts; cell proliferation; chemical composition; chitosan; dose response; encapsulation; humans; inhibitory concentration 50; lung neoplasms; neoplasm cells; particle size distribution; shelf life; solvents; thermal properties
Abstract:
... Blueberries are rich in anthocyanins. Short shelf life of fresh blueberries and chemical instability of anthocyanins make the handling of blueberries very challenging. Hence, the objectives of this study are to characterize anthocyanin contents of blueberry water and acetone extracts and to encapsulate the extracts with chitosan. The encapsulated material was analyzed for its particle size distrib ...
DOI:
10.1007/s00217-016-2819-5

94. Insecticidal action of mammalian galectin-1 against diamondback moth (Plutella xylostella)

Author:
Chen, Shiang Jiuun; Chen, Nien-Ting; Wang, Siou-Hua; Hsu, Ju Chun; Ding, Wang-Hsien; Kuo-Huang, Ling-Long; Huang, Rong Nan
Source:
Pest management science 2009 v.65 no.8 pp. 923-930
ISSN:
1526-498X
Subject:
Plutella xylostella; insect pests; animal proteins; insecticidal properties; insect anatomy; chitosan; chitin; mechanism of action; larvae; larval development; insect growth; recombinant proteins; histochemistry; epithelial cells; villi; ultrastructure; midgut; intestinal microorganisms; in vitro studies; dosage; dose response; protein binding
Abstract:
... BACKGROUND: Previous studies showed that mammalian galectin-1 (GAL1) could interact with chitosan or chitin, one component of the peritrophic membrane (PM). This finding suggests that the PM could be a target of GAL1, which prompted the authors to explore the effect of GAL1 on larval growth and its potential mechanism.RESULTS: The development of Plutella xylostella (L.) larvae was significantly di ...
DOI:
10.1002/ps.1775
PubMed:
19437454

95. Interactions of oligochitosan with blood components

Author:
Tong Sun; Xi Guo; Rui Zhong; Lu Ma; Hao Li; Zhipeng Gu; Junwen Guan; Hong Tan; Chao You; Meng Tian
Source:
International journal of biological macromolecules 2019 v.124 pp. 304-313
ISSN:
0141-8130
Subject:
Fourier transform infrared spectroscopy; bioactive properties; carbon; chemical structure; chitosan; coagulation; complement; dose response; erythrocytes; ethanol; fractionation; hemolysis; hydrogen peroxide; nuclear magnetic resonance spectroscopy; platelet activation; risk; stable isotopes
Abstract:
... Oligochitosan (OCHI) is known to have some specific biological activities. However, its interactions with blood components and related correlation with molecular structures remains to be clarified due to its growing use in biomedical areas. Herein, a series of OCHI were prepared by hydrogen peroxide induced degradation combined fractionation in ethanol solutions and their molecular structures were ...
DOI:
10.1016/j.ijbiomac.2018.11.109

96. Ionic liquid-mediated delivery of insulin to buccal mucosa

Author:
Amogh Vaidya; Samir Mitragotri
Source:
Journal of controlled release 2020 v.327 pp. 26-34
ISSN:
0168-3659
Subject:
bioadhesives; biodegradability; blood glucose; blood serum; chitosan; choline; confocal microscopy; dose response; drugs; gels; insulin; ionic liquids; models; modulus of elasticity; mucosa; patients; peptides; pharmacokinetics; proteins; rats; swine; therapeutics; viscoelasticity
Abstract:
... Buccal drug delivery offers a potential non-invasive means of delivering therapeutics to patients. Despite the promise, the feasibility of transporting proteins and peptides into systemic circulation from buccal administration remains a daunting challenge. Here, we report the fabrication of a biodegradable polymeric patch for buccal delivery of insulin using chitosan as the mucoadhesive matrix and ...
DOI:
10.1016/j.jconrel.2020.07.037

97. Marine polysaccharide laminarin embedded ZnO nanoparticles and their based chitosan capped ZnO nanocomposites: Synthesis, characterization and in vitro and in vivo toxicity assessment

Author:
Sekar Vijayakumar; Jingdi Chen; Viswanathan Kalaiselvi; Kanchanlata Tungare; Mustansir Bhori; Zaira I. González-Sánchez; Esteban F. Durán-Lara
Source:
Environmental research 2022 v.213 pp. 113655
ISSN:
0013-9351
Subject:
Danio rerio; Vigna radiata; chitosan; colorectal neoplasms; cytotoxicity; dose response; embryotoxicity; fibroblasts; humans; markets; nanocomposites; phytotoxicity; research; seed germination; survival rate; toxicity testing; viability
Abstract:
... In the current scenario where more and more products containing nanomaterials are on the technological or pharmaceutical market, it is crucial to have a thorough knowledge of their toxicity before proposing possible applications. A proper analysis of the toxicity of the nanoproducts should include both in vitro and in vivo biological approaches and should consider that the synthesis and purificati ...
DOI:
10.1016/j.envres.2022.113655

98. Marine-Derived Chitosan Nanoparticles Improved the Intestinal Histo-Morphometrical Features in Association with the Health and Immune Response of Grey Mullet (Liza ramada)

Author:
Mahmoud A.O. Dawood; Mahmoud S. Gewaily; Ali A. Soliman; Mustafa Shukry; Asem A. Amer; Elsayed M. Younis; Abdel-Wahab A. Abdel-Warith; Hien Van Doan; Adel H. Saad; Mohamed Aboubakr; Hany M.R. Abdel-Latif; Sabreen E. Fadl
Source:
Marine drugs 2020 v.18 no.12 pp. -
ISSN:
1660-3397
Subject:
Liza ramada; Petrorhagia; albumins; body weight; catalase; chitosan; correlation; diet; dosage; dose response; drugs; erythrocytes; exhibitions; feed conversion; fish; globulins; glutathione peroxidase; goblet cells; height; hematocrit; hemoglobin; histology; immune response; intestinal mucosa; lysozyme; malondialdehyde; microvilli; morphometry; nanoparticles; phagocytosis; protein content; serosa; specific growth rate; thickness; villi; weight gain; width
Abstract:
... Marine-derived substances are known for their beneficial influences on aquatic animals’ performances and are recommended to improve intestinal health, immunity, and anti-oxidative status. The present study investigates the role of chitosan nanoparticles on the intestinal histo-morphometrical features in association with the health and immune response of Grey Mullet (Liza ramada). Chitosan nanopart ...
DOI:
10.3390/md18120611

99. Microencapsulation of ergosterol and Agaricus bisporus L. extracts by complex coacervation using whey protein and chitosan: Optimization study using response surface methodology

Author:
Adenilson Renato Rudke; Sandrina A. Heleno; Isabel P. Fernandes; M.A. Prieto; Odinei Hess Gonçalves; Alírio E. Rodrigues; Isabel C.F.R. Ferreira; Maria Filomena Barreiro
Source:
Lebensmittel-Wissenschaft + Technologie 2019 v.103 pp. 228-237
ISSN:
0023-6438
Subject:
Agaricus bisporus; chitosan; dose response; ergosterol; microencapsulation; response surface methodology; temperature; whey protein
Abstract:
... In the present work microencapsulation was applied to an ergosterol enriched extract (EEE) from Agaricus bisporus L. and pure ergosterol (PE) using a complex coacervation process. The process was optimized following two steps: (i) using response surface methodology to optimize the conditions of temperature (T, 55 to 95 °C), protein-to-chitosan ratio (P/C, 0.5 to 10.5), maximizing yield (Y1, %, w/w ...
DOI:
10.1016/j.lwt.2019.01.018

100. Microwave-assisted synthesis of chitosan biguanidine hydrochloride and its regulation on InsR and GLUT2 in insulin resistant HepG2 cells

Author:
Shengsheng Zhang; Hai Zhang; Li Wang; Xiaofei Liu; Yuntang Wu
Source:
RSC advances 2017 v.7 no.17 pp. 10108-10117
ISSN:
2046-2069
Subject:
Fourier transform infrared spectroscopy; X-ray diffraction; chemical structure; chitosan; diabetes; dicyandiamide; dose response; glucose; hepatoma; human cell lines; humans; insulin receptors; insulin resistance; metformin; microwave radiation; microwave treatment; models; nuclear magnetic resonance spectroscopy; therapeutics; titration; transport proteins
Abstract:
... Insulin receptor (InsR) and GLUTs play a very important role in pathophysiological changes in terms of diabetes and insulin resistance, and metformin can regulate their expression and activity in order to alleviate insulin resistance. By reference to the molecular structure of metformin, chitosan biguanidine hydrochloride (CSGH) was synthesized by reacting chitosan (CS) with dicyandiamide under mi ...
DOI:
10.1039/c6ra25998g