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1. Acetaminophen Disrupts the Development of Pharyngeal Arch-Derived Cartilage and Muscle in Zebrafish

Author:
Derrick M. Glasco; Zhidong Wang; Seonwoo Kang; Avery T. Funkhouser
Source:
Journal of developmental biology 2022 v.10 no.3 pp. -
ISSN:
2221-3759
Subject:
Danio rerio; acetaminophen; apoptosis; cartilage; chondrogenesis; collagen; embryogenesis; lethal dose; liver; muscles; neural crest; pharynx
Abstract:
... Acetaminophen is a common analgesic, but its potential effects on early embryonic development are not well understood. Previous studies using zebrafish (Danio rerio) have described the effects of acetaminophen on liver development and physiology, and a few have described gross physiological and morphological defects. Using a high but non-embryonic lethal dose of acetaminophen, we probed for defect ...
DOI:
10.3390/jdb10030030

2. Biomaterial-mediated presentation of wnt5a mimetic ligands enhances chondrogenesis and metabolism of stem cells by activating non-canonical Wnt signaling

Author:
Yingrui Deng; Xiaoting Zhang; Rui Li; Zhuo Li; Boguang Yang; Peng Shi; Honglu Zhang; Chunming Wang; Chunyi Wen; Gang Li; Liming Bian
Source:
Biomaterials 2022 v.281 pp. 121316
ISSN:
0142-9612
Subject:
biocompatible materials; biomarkers; biosynthesis; cartilage; chondrogenesis; encapsulation; gene expression; glucose; humans; hyaluronic acid; hydrogels; hypertrophy; ligands; medicine; mitochondria; musculoskeletal system; peptides; tissue repair
Abstract:
... The presentation of development-relevant bioactive cues by biomaterial scaffolds is essential to the guided differentiation of seeded human mesenchymal stem cells (hMSCs) and subsequent tissue regeneration. Wnt5a is a critical non-canonical Wnt signaling ligand and plays a key role in the development of musculoskeletal tissues including cartilage. Herein we investigate the efficacy of biofunctiona ...
DOI:
10.1016/j.biomaterials.2021.121316

3. Chsy1 deficiency reduces extracellular matrix productions and aggravates cartilage injury in osteoarthritis

Author:
Zhaojie Lyu; Yifeng Da; Hongkai Liu; Zhihao Wang; Yong Zhu; Jing Tian
Source:
Gene 2022 v.827 pp. 146466
ISSN:
0378-1119
Subject:
biomarkers; bone formation; cartilage; cell lines; chondrocytes; chondrogenesis; chondroitin sulfate; extracellular matrix; genes; glycosyltransferases; hypertrophy; mice; osteoarthritis
Abstract:
... Osteoarthritis (OA) is a kind of degenerative joint disease marked by the destruction of articular cartilage due to the degeneration of chondrocytes. CHSY1, one of the glycosyltransferases, is involved in the synthesis of chondroitin sulfate. Herein, we found that the expression of Chsy1 was decreased in the knee cartilage of OA rats. In order to investigate the role of CHSY1 in chondrogenesis and ...
DOI:
10.1016/j.gene.2022.146466

4. Genetic basis investigation of wattle phenotype in goat using genome‐wide sequence data

Author:
Wei‐Yi Zhang; Ying Yuan; Hao‐Yuan Zhang; Yong‐Meng He; Cheng‐Li Liu; Lu Xu; Bai‐Gao Yang; Hang‐Xing Ren; Gao‐Fu Wang; Guang‐Xin E
Source:
Animal genetics 2022 v.53 no.5 pp. 700-705
ISSN:
0268-9146
Subject:
animal genetics; cartilage; chondrogenesis; chromosomes; ears; gene ontology; genome; genome-wide association study; goats; neck; phenotype
Abstract:
... In domestic goats, wattles often appear in even numbers, mostly on the neck and a few under the ear. Goat wattle is composed of ectopic cartilage tissue covered by skin and was reported as a dominant inheritance. Thirty‐eight goats from two Southwest Chinese breeds were studied to elucidate the genetic basis of wattle phenotype in goat. Their genomes were sequenced for wide‐genome selective sweep ...
DOI:
10.1111/age.13235

5. Geometric analysis of chondrogenic self-organisation of embryonic limb bud cells in micromass culture

Author:
Rebecca A. Rolfe; Claire A. Shea; Paula Murphy
Source:
Cell and tissue research 2022 v.388 no.1 pp. 49-62
ISSN:
0302-766X
Subject:
analytical methods; antagonists; bone formation; cartilage; chondrogenesis; gene expression; geometry; hypertrophy; ligands; models; research; vertebrates; wnt proteins
Abstract:
... Spatial and temporal control of chondrogenesis generates precise, species-specific patterns of skeletal structures in the developing vertebrate limb. The pattern-template is laid down when mesenchymal cells at the core of the early limb bud condense and undergo chondrogenic differentiation. Although the mechanisms involved in organising such complex patterns are not fully understood, the interplay ...
DOI:
10.1007/s00441-021-03564-y

6. Induction of chondrogenesis with a RANKL-binding peptide, WP9QY, in vitro and in vivo in a rabbit model

Author:
Yuriko Furuya; Hisashi Mera; Maki Itokazu; Shozaburo Terai; Hiroaki Nakamura; Shigeyuki Wakitani; Hisataka Yasuda
Source:
Biochemical and biophysical research communications 2022 v.602 pp. 98-104
ISSN:
0006-291X
Subject:
bone formation; cartilage; chondrocytes; chondrogenesis; drugs; humans; ligands; osteoarthritis; osteoblasts; osteoclasts; peptides; rabbits; research
Abstract:
... WP9QY (W9) is a receptor activator of nuclear factor-κB ligand (RANKL)-binding peptide that inhibits osteoclastogenesis by blunting the RANKL-RANK interaction, and also increases osteoblastogenesis via RANKL reverse signaling. W9 has dual effects on osteoclasts and osteoblasts; however, it is unknown whether the peptide has an effect on chondrocytes. Here, we report that W9 induces proliferation a ...
DOI:
10.1016/j.bbrc.2022.03.019

7. Maternal effect and dietary supplementation of estradiol-17β on female zebrafish (Danio rerio) affects the swimming behavior and stress-coping styles of its offspring

Author:
Su Mei Wu; Yu-Jen Tseng; Te-Hao Chen
Source:
Comparative biochemistry and physiology 2022 v.252 pp. 109211
ISSN:
1532-0456
Subject:
Danio rerio; cartilage; chondrogenesis; cold stress; cortisol; dietary supplements; fecundity; females; fish; juveniles; larvae; males; maternal effect; progeny
Abstract:
... Extrinsic estradiol-17β (E2) is an environmental hormone. Female fish exposure to waterborne E2 might affect the development of craniofacial cartilage of its offspring. The present study investigates the effects of maternal E2 on larval craniofacial cartilage development by administering oral feed containing E2 (F-E2) to female zebrafish, and examines whether the swimming behavior and their stress ...
DOI:
10.1016/j.cbpc.2021.109211

8. Mutation of foxl1 Results in Reduced Cartilage Markers in a Zebrafish Model of Otosclerosis

Author:
Alexia Hawkey-Noble; Justin A. Pater; Roshni Kollipara; Meriel Fitzgerald; Alexandre S. Maekawa; Christopher S. Kovacs; Terry-Lynn Young; Curtis R. French
Source:
Genes 2022 v.13 no.7 pp. -
ISSN:
2073-4425
Subject:
Danio rerio; bone density; bone formation; calcification; cartilage; chondrogenesis; collagen; genes; mammals; meta-analysis; middle ear; mineralization; models; mutants; mutation; osteoporosis; skeletal development; skeleton; transcription factors
Abstract:
... Bone diseases such as otosclerosis (conductive hearing loss) and osteoporosis (low bone mineral density) can result from the abnormal expression of genes that regulate cartilage and bone development. The forkhead box transcription factor FOXL1 has been identified as the causative gene in a family with autosomal dominant otosclerosis and has been reported as a candidate gene in GWAS meta-analyses f ...
DOI:
10.3390/genes13071107

9. Nitrogen-doped titanium dioxide films fabricated via magnetron sputtering for vascular stent biocompatibility improvement

Author:
Zhilei Sun; Igor A. Khlusov; Kirill E. Evdokimov; Maksim E. Konishchev; Oleg S. Kuzmin; Olga G. Khaziakhmatova; Vladimir V. Malashchenko; Larisa S. Litvinova; Sven Rutkowski; Johannes Frueh; Anna I. Kozelskaya; Sergei I. Tverdokhlebov
Source:
Journal of colloid and interface science 2022 v.626 pp. 101-112
ISSN:
0021-9797
Subject:
adipose tissue; biocompatibility; cell adhesion; cell proliferation; chondrogenesis; energy; films (materials); glass; humans; nitrogen; oxygen; titanium dioxide; wettability
Abstract:
... Nowadays, vascular stents are commonly used to treat cardiovascular diseases. This article focuses on the influence of nitrogen doping of titanium dioxide thin films, utilized for coating metallic stents to improve their biological properties and biocompatibility. The hereby-investigated titanium oxide thin films are fabricated by magnetron sputtering in a reactive gas atmosphere consisting of arg ...
DOI:
10.1016/j.jcis.2022.06.114

10. The Role of Protein Kinase CK2 in Development and Disease Progression: A Critical Review

Author:
Daniel Halloran; Venu Pandit; Anja Nohe
Source:
Journal of developmental biology 2022 v.10 no.3 pp. -
ISSN:
2221-3759
Subject:
adipogenesis; adulthood; bone formation; chondrogenesis; disease progression; embryonic mortality; evolution; immune response; neurogenesis; neurons; protein kinases; spermatogenesis; therapeutics; viability
Abstract:
... Protein kinase CK2 (CK2) is a ubiquitous holoenzyme involved in a wide array of developmental processes. The involvement of CK2 in events such as neurogenesis, cardiogenesis, skeletogenesis, and spermatogenesis is essential for the viability of almost all organisms, and its role has been conserved throughout evolution. Further into adulthood, CK2 continues to function as a key regulator of pathway ...
DOI:
10.3390/jdb10030031

11. Supplementation of articular cartilage-derived chondroprogenitors with bone morphogenic protein-9 enhances chondrogenesis without affecting hypertrophy

Author:
Kawin Padmaja; Soosai Manickam Amirtham; Grace Rebekah; Solomon Sathishkumar; Elizabeth Vinod
Source:
Biotechnology letters 2022 v.44 no.9 pp. 1037-1049
ISSN:
0141-5492
Subject:
adhesion; biotechnology; cell differentiation; chondrocytes; chondrogenesis; culture media; fibronectins; gene expression; glycosaminoglycans; growth models; humans; hypertrophy; osteoarthritis; parathyroid hormone; prostheses; qualitative analysis; therapeutics; toluidine blue
Abstract:
... INTRODUCTION: Chondroprogenitors (CPCs) have emerged as a promising cellular therapy for cartilage-related pathologies due to their inherent primed chondrogenic potential. Studies report that the addition of growth factors such as parathyroid hormone (PTH) and Bone Morphogenic Protein (BMP) enhance the chondroinducive potential in chondrocytes and mesenchymal stem cells. This study evaluated if su ...
DOI:
10.1007/s10529-022-03280-9

12. Temporospatial regulation of intraflagellar transport is required for the endochondral ossification in mice

Author:
Hiroyuki Yamaguchi; Megumi Kitami; Karin H. Uchima Koecklin; Li He; Jianbo Wang; William R. Lagor; Daniel S. Perrien; Yoshihiro Komatsu
Source:
Developmental biology 2022 v.482 pp. 91-100
ISSN:
0012-1606
Subject:
Erinaceidae; bone formation; chondrocytes; chondrogenesis; mutants
Abstract:
... Ciliogenic components, such as the family of intraflagellar transport (IFT) proteins, are recognized to play key roles in endochondral ossification, a critical process to form most bones. However, the unique functions and roles of each IFT during endochondral ossification remain unclear. Here, we show that IFT20 is required for endochondral ossification in mice. Utilizing osteo-chondrocyte lineage ...
DOI:
10.1016/j.ydbio.2021.12.004

13. A bioprintable gellan gum/lignin hydrogel: a smart and sustainable route for cartilage regeneration

Author:
Maria A. Bonifacio; Stefania Cometa; Andrea Cochis; Annachiara Scalzone; Piergiorgio Gentile; Alessandro C. Scalia; Lia Rimondini; Piero Mastrorilli; Elvira De Giglio
Source:
International journal of biological macromolecules 2022 v.216 pp. 336-346
ISSN:
0141-8130
Subject:
Staphylococcus epidermidis; antibacterial properties; ascorbic acid; cartilage; cell growth; chondrogenesis; collagen; crosslinking; gellan gum; hydrogels; lignin; magnesium
Abstract:
... In this work a hydrogel, based on a blend of two gellan gums with different acyl content embedding lignin (up to 0.4%w/v) and crosslinked with magnesium ions, was developed for cartilage regeneration. The physico-chemical characterizations established that no chemical interaction between lignin and polysaccharides was detected. Lignin achieved up to 80 % of ascorbic acid's radical scavenging activ ...
DOI:
10.1016/j.ijbiomac.2022.07.002

14. A sonication-induced silk-collagen hydrogel for functional cartilage regeneration

Author:
Shihe Long; Danyang Huang; Zihan Ma; Shuaiguang Shi; Yun Xiao; Xingdong Zhang
Source:
Journal of materials chemistry B 2022 v.10 no.26 pp. 5045-5057
ISSN:
2050-7518
Subject:
cartilage; cell culture; chondrogenesis; collagen; fibroins; gene expression; glycosaminoglycans; hydrogels; rabbits; shrinkage; sonication
Abstract:
... Cartilage tissue has limited self-regeneration capacity and current treatment methods often result in fibrocartilage formation. Although collagen has shown the ability to induce chondrogenesis of mesenchymal stem cells (MSCs) and regenerate hyaline cartilage, the application of a pure collagen hydrogel is inherently limited by its fast degradation, poor mechanical properties and excessive cell-med ...
DOI:
10.1039/d2tb00564f

15. 3D-Bioprinted Difunctional Scaffold for In Situ Cartilage Regeneration Based on Aptamer-Directed Cell Recruitment and Growth Factor-Enhanced Cell Chondrogenesis

Author:
Zhen Yang; Tianyuan Zhao; Cangjian Gao; Fuyang Cao; Hao Li; Zhiyao Liao; Liwei Fu; Pinxue Li; Wei Chen; Zhiqiang Sun; Shuangpeng Jiang; Zhuang Tian; Guangzhao Tian; Kangkang Zha; Tingting Pan; Xu Li; Xiang Sui; Zhiguo Yuan; Shuyun Liu; Quanyi Guo
Source:
ACS applied materials & interfaces 2021 v.13 no.20 pp. 23369-23383
ISSN:
1944-8252
Subject:
biodegradability; bioprinting; cartilage; cell adhesion; chondrogenesis; extracellular matrix; gelatin; oligonucleotides; polymers; rabbits; strength (mechanics); therapeutics
Abstract:
... Articular cartilage (AC) lesions are fairly common but remain an obstacle for clinicians and researchers due to their poor self-healing capacity. Recently, a promising therapy based on the recruitment of autologous mesenchymal stem cells (MSCs) has been developed for the regeneration of full-thickness cartilage defects in the knee joint. In this study, a 3D-bioprinted difunctional scaffold was dev ...
DOI:
10.1021/acsami.1c01844

16. 3D-Printed Porous Scaffolds of Hydrogels Modified with TGF-β1 Binding Peptides to Promote In Vivo Cartilage Regeneration and Animal Gait Restoration

Author:
Xiaoquan Ding; Jingming Gao; Xiaoye Yu; Jiayue Shi; Jun Chen; Lin Yu; Shiyi Chen; Jiandong Ding
Source:
ACS applied materials & interfaces 2022 v.14 no.14 pp. 15982-15995
ISSN:
1944-8252
Subject:
bone formation; cartilage; chemical bonding; chondrogenesis; gait; gelatin; hydrogels; hydroxyapatite; osteoarthritis; peptides; therapeutics; tissue repair
Abstract:
... The treatment of cartilage injury and osteoarthritis has been a classic problem for many years. The idea of in situ tissue regeneration paves a way for osteochondral repair in vivo. Herein, a hydrogel scaffold linked with bioactive peptides that can selectively adsorb transforming growth factor β1 (TGF-β1) was hypothesized to not only afford cell ingrowth space but also induce the endogenous TGF-β ...
DOI:
10.1021/acsami.2c00761

17. Altered microRNAs in C3H10T1/2 cells induced by p.E95K mutant IHH signaling

Author:
Wei Zhou; Luan Chen; Hao Wu; Ting Wang; Gang Ma; Baocheng Wang; Cong Wang; Na Zhang; Yingtian Zhang; Lin He; Shengying Qin; Xiaofang Sun; Hai Zhang; Lu Shen
Source:
Hereditas 2021 v.158 no.1 pp. 48
ISSN:
1601-5223
Subject:
Erinaceidae; cartilage; cell lines; chondrogenesis; gene expression; heterozygosity; microRNA; microarray technology; mutants; pathogenesis; reporter genes
Abstract:
... BACKGROUND: Indian Hedgehog (IHH), an important cell signaling protein, plays a key regulatory role in development of cartilage and chondrogenesis. Earlier studies have shown that heterozygous missense mutations in IHH gene may cause brachydactyly type A1 (BDA1), an autosomal dominant inheritance disease characterized by apparent shortness or absence of the middle phalanges of all digits. MicroRNA ...
DOI:
10.1186/s41065-021-00207-8

18. Anti-Inflammatory and Prochondrogenic In Situ-Formed Injectable Hydrogel Crosslinked by Strontium-Doped Bioglass for Cartilage Regeneration

Author:
Zhuochang Cai; Ying Li; Wei Song; Yaohua He; Haiyan Li; Xudong Liu
Source:
ACS applied materials & interfaces 2021 v.13 no.50 pp. 59772-59786
ISSN:
1944-8252
Subject:
biocompatible materials; bone marrow; cartilage; chondrogenesis; crosslinking; gene expression; glycosaminoglycans; humans; hydrogels; inflammation; macrophages; models; phenotype; secretion
Abstract:
... Directed differentiation of bone marrow mesenchymal stem cells (BMSCs) toward chondrogenesis plays a predominant role in cartilage repair. However, the uncontrolled inflammatory response to implants is found to impair the stability of scaffolds and the cartilage regeneration outcome. Herein, we fabricated an injectable hydrogel crosslinked by strontium-doped bioglass (SrBG) to modulate both human ...
DOI:
10.1021/acsami.1c20565

19. Assessment of a novel activity of Acacia nilotica leaf extract for chondrogenesis induction of Mesenchymal stem cells for dental applications

Author:
Yasir B. Fadhil; Mohammed Hadi Jaber; Hind M. Ahmed
Source:
Phytomedicine plus 2021 v.1 no.4 pp. 100087
ISSN:
2667-0313
Subject:
Acacia; Vachellia nilotica; cartilage; chondrocytes; chondrogenesis; collagen; ethanol; glycosaminoglycans; leaf extracts; orthopedics; protein synthesis; secondary metabolites; tooth pulp
Abstract:
... The Dearth of the self-rejuvenation capability of cartilage tissue is one of the frequent problems encountered by the dentist and orthopedic surgeons. Acacia nilotica commonly known as (babul, thorny acacia, Egyptian acacia or thorn mimosa) has wide range of medicinal uses. The current study was carried out to investigate the herbal-based chondrogenesis inducing ability of leaves extract of A. nil ...
DOI:
10.1016/j.phyplu.2021.100087

20. Bioinspired Injectable Hydrogels Dynamically Stiffen and Contract to Promote Mechanosensing-Mediated Chondrogenic Commitment of Stem Cells

Author:
Aman Mahajan; Akhilesh Singh; Dipak Datta; Dhirendra S. Katti
Source:
ACS applied materials & interfaces 2022 v.14 no.6 pp. 7531-7550
ISSN:
1944-8252
Subject:
Bombyx mori; carboxymethylcellulose; cartilage; chondrogenesis; fibroins; gelatin; hydrogels; mechanotransduction; silk
Abstract:
... Developing stiff and resilient injectable hydrogels that can mechanically support load-bearing joints while enabling chondrogenic differentiation of stem cells is a major challenge in the field of cartilage tissue engineering. In the present work, a triple-network injectable hydrogel system was engineered using Bombyx mori silk fibroin, carboxymethyl cellulose (CMC), and gelatin. The developed hyd ...
DOI:
10.1021/acsami.1c11840

21. Bioinspired polysaccharide hybrid hydrogel promoted recruitment and chondrogenic differentiation of bone marrow mesenchymal stem cells

Author:
Zhulian Li; Hongfu Cao; Yang Xu; Xing Li; XiaoWen Han; Yujiang Fan; Qing Jiang; Yong Sun; Xingdong Zhang
Source:
Carbohydrate polymers 2021 v.267 pp. 118224
ISSN:
0144-8617
Subject:
adhesion; adsorption; biomimetics; bone marrow; cartilage; catechol; chondrogenesis; collagen; dopamine; gene expression; hyaluronic acid; hydrogels; rabbits; secretion
Abstract:
... Cartilage regeneration by biomimetic cartilage matrix with synchronously recruited stem cells was one of ideal strategies. Inspired by catechol for proteins adhesion, dopamine modified polysaccharide hybrid hydrogel (HD-C) was prepared by integrating collagen I (Col I) and hyaluronic acid derivatives (HA-DN) with sulfhydryl modified polysaccharide hybrid hydrogel (HS-C) as control. Because of doub ...
DOI:
10.1016/j.carbpol.2021.118224

22. CRISPR activation of long non-coding RNA DANCR promotes bone regeneration

Author:
Nuong Thi Kieu Nguyen; Yu-Han Chang; Vu Anh Truong; Mu-Nung Hsu; Nam Ngoc Pham; Chin-Wei Chang; Yi-Hsiu Wu; Yi-Hao Chang; Hung Li; Yu-Chen Hu
Source:
Biomaterials 2021 v.275 pp. 120965
ISSN:
0142-9612
Subject:
Staphylococcus aureus; Streptococcus pyogenes; biocompatible materials; cartilage; chondrogenesis; non-coding RNA; rats; skull; therapeutics
Abstract:
... Healing of large calvarial bone defects in adults adopts intramembranous pathway and is difficult. Implantation of adipose-derived stem cells (ASC) that differentiate towards chondrogenic lineage can switch the bone repair pathway and improve calvarial bone healing. Long non-coding RNA DANCR was recently uncovered to promote chondrogenesis, but its roles in rat ASC (rASC) chondrogenesis and bone h ...
DOI:
10.1016/j.biomaterials.2021.120965

23. Calcium peroxide aids tyramine-alginate gel to crosslink with tyrosinase for efficient cartilage repair

Author:
Chin-Chean Wong; Chu-Xuan Lu; Er-Chen Cho; Po-Wei Lee; Nai-Wen Chi; Po-Yen Lin; Pei-Ru Jheng; Hsin-Lung Chen; Bradley W. Mansel; Yu-Ming Chen; Chih-Hwa Chen; Er-Yuan Chuang
Source:
International journal of biological macromolecules 2022 v.208 pp. 299-313
ISSN:
0141-8130
Subject:
alginates; bioadhesion; bioadhesives; calcium; calcium peroxide; cartilage; cell viability; chondrocytes; chondrogenesis; crosslinking; encapsulation; extracellular matrix; gels; oxygen; strength (mechanics); therapeutics; tyramine
Abstract:
... The innate cartilage extracellular matrix is avascular and plays a vital role in innate chondrocytes. Recapping the crucial components of the extracellular matrix in engineered organs via polymeric gels and bioinspired approaches is promising for improving the regenerative aptitude of encapsulated cartilage/chondrocytes. Conventional gel formation techniques for polymeric materials rely on employi ...
DOI:
10.1016/j.ijbiomac.2022.03.044

24. Carboxymethyl chitosan-assisted MnOx nanoparticles: Synthesis, characterization, detection and cartilage repair in early osteoarthritis

Author:
Ting Lin; Yang Zhao; Jieli Chen; Cuixi Wu; Zhan Li; Yumei Cao; Rong Lu; Jinwei Zhang; Chen Zhao; Yao Lu
Source:
Carbohydrate polymers 2022 v.294 pp. 119821
ISSN:
0144-8617
Subject:
biocompatibility; cartilage; chitosan; chondrogenesis; magnetism; manganese monoxide; osteoarthritis; peptides; rats; therapeutics
Abstract:
... While the early detection and repair of cartilage lesions are crucial in the treatment of osteoarthritis (OA), they remain challenging because neither clinically used medicines nor magnetic resonance (MR) contrast agents can achieve detection and repair simultaneously. Here, we conjugated carboxymethyl chitosan (CMC) with a cartilage-targeting peptide (WYRGRL, termed WY) and then synthesized CMC-a ...
DOI:
10.1016/j.carbpol.2022.119821

25. Cartilage from human-induced pluripotent stem cells: comparison with neo-cartilage from chondrocytes and bone marrow mesenchymal stromal cells

Author:
Alejandro Rodríguez Ruiz; Amanda Dicks; Margo Tuerlings; Koen Schepers; Melissa van Pel; Rob G. H. H. Nelissen; Christian Freund; Christine L. Mummery; Valeria Orlova; Farshid Guilak; Ingrid Meulenbelt; Yolande F. M. Ramos
Source:
Cell and tissue research 2021 v.386 no.2 pp. 309-320
ISSN:
0302-766X
Subject:
bone marrow; cartilage; chondrocytes; chondrogenesis; collagen; flow cytometry; humans; immunohistochemistry; medicine; research
Abstract:
... Cartilage has little intrinsic capacity for repair, so transplantation of exogenous cartilage cells is considered a realistic option for cartilage regeneration. We explored whether human-induced pluripotent stem cells (hiPSCs) could represent such unlimited cell sources for neo-cartilage comparable to human primary articular chondrocytes (hPACs) or human bone marrow-derived mesenchymal stromal cel ...
DOI:
10.1007/s00441-021-03498-5

26. Chitosan hydrogel/3D-printed poly(ε‐caprolactone) hybrid scaffold containing synovial mesenchymal stem cells for cartilage regeneration based on tetrahedral framework nucleic acid recruitment

Author:
Pinxue Li; Liwei Fu; Zhiyao Liao; Yu Peng; Chao Ning; Cangjian Gao; Daxu Zhang; Xiang Sui; Yunfeng Lin; Shuyun Liu; Chunxiang Hao; Quanyi Guo
Source:
Biomaterials 2021 v.278 pp. 121131
ISSN:
0142-9612
Subject:
DNA; biocompatible materials; cartilage; cell proliferation; chitosan; chondrogenesis; therapeutics
Abstract:
... Articular cartilage (AC) injury repair has always been a difficult problem for clinicians and researchers. Recently, a promising therapy based on mesenchymal stem cells (MSCs) has been developed for the regeneration of cartilage defects. As endogenous articular stem cells, synovial MSCs (SMSCs) possess strong chondrogenic differentiation ability and articular specificity. In this study, a cartilag ...
DOI:
10.1016/j.biomaterials.2021.121131

27. Chitosan/polycaprolactone multilayer hydrogel: A sustained Kartogenin delivery model for cartilage regeneration

Author:
Arezou Baharlou Houreh; Elahe Masaeli; Mohammad Hossein Nasr-Esfahani
Source:
International journal of biological macromolecules 2021 v.177 pp. 589-600
ISSN:
0141-8130
Subject:
cartilage; chitosan; chondrogenesis; gene expression; histology; hydrogels; hypertrophy; infrared spectroscopy; models; synergism; therapeutics
Abstract:
... Cartilage regeneration using biomaterial-guided delivery systems presents improved therapeutic efficacy of the biomolecules while minimizing side effects. Here, our hypothesis was to design a multilayer scaffold of chitosan (CS) hydrogel and polycaprolactone (PCL) mat to enhance the mechanical properties, integrity and stability of CS, especially for subsequent in vivo transplantation. After conju ...
DOI:
10.1016/j.ijbiomac.2021.02.122

28. Chondrocyte secretome enriched microparticles encapsulated with the chondrocyte membrane to facilitate the chondrogenesis of BMSCs and reduce hypertrophy

Author:
Zizhao Tang; Yan Lu; Shixin Zhang; Jing Wang; Qiguang Wang; Yumei Xiao; Xingdong Zhang
Source:
Journal of materials chemistry B 2021 v.9 no.48 pp. 9989-10002
ISSN:
2050-7518
Subject:
bone marrow; cartilage; cell proliferation; chemistry; chondrocytes; chondrogenesis; coculture; cytokines; encapsulation; gene expression; hypertrophy; phenotype; secretion
Abstract:
... Co-culture of chondrocytes and mesenchymal stem cells (MSCs) represents an effective way to stimulate the chondrogenesis of MSCs and reduce hypertrophy, but the limited donor site supply and the requirement of two-stage operations are among the major barriers of using autologous chondrocytes in clinical settings. With recent evidence indicating that the chondrogenic effects of the above co-culture ...
DOI:
10.1039/d1tb02319e

29. Citrate-based mussel-inspired magnesium whitlockite composite adhesives augmented bone-to-tendon healing

Author:
Xiaowei Yuan; Yitao Zhao; Jintao Li; Xuncai Chen; Zhihui Lu; Lianyong Li; Jinshan Guo
Source:
Journal of materials chemistry B 2021 v.9 no.39 pp. 8202-8210
ISSN:
2050-7518
Subject:
anterior cruciate ligament; bone formation; chemistry; chondrogenesis; magnesium
Abstract:
... Citrate-based mussel-inspired whitlockite composite adhesives (CMWAs) were developed and administered to the bone–tendon interface in anterior cruciate ligament (ACL) reconstruction. CMWAs could improve the initial bone–tendon bonding strength, promote the bony inward growth from the bone tunnel and enhance the chondrogenesis and osteogenesis of the bone–tendon interface, thus augmenting bone-to-t ...
DOI:
10.1039/d1tb01710a

30. Conditioned medium from mesenchymal stem cells improves condylar resorption induced by mandibular distraction osteogenesis in a rat model

Author:
Wataru Katagiri; Satoshi Endo; Ryoko Takeuchi; Daisuke Suda; Naoaki Saito; Tadaharu Kobayashi
Source:
Heliyon 2021 v.7 no.3 pp. e06530
ISSN:
2405-8440
Subject:
aesthetics; animal models; bone formation; cartilage; caudal vein; chondrogenesis; gene expression; head; micro-computed tomography; quantitative polymerase chain reaction; rats; resorption; surgery
Abstract:
... Condylar resorption (CR) after surgical orthognathic treatment is defined as dysfunctional remodeling of the temporomandibular joint manifested by morphological changes with decreased condylar head volume that cause occlusal and esthetic changes. Although both conservative and surgical treatment strategies have been employed for the treatment of CR, effective procedures have not been established t ...
DOI:
10.1016/j.heliyon.2021.e06530

31. Development of chimeric forms of the matrix metalloproteinase 2 collagen binding domain as artificial membrane binding proteins for targeting stem cells to cartilage lesions in osteoarthritic joints

Author:
Anais Dabbadie; Anna Salerno; Adam Perriman; Lu-Yun Lian; Anthony P. Hollander
Source:
Biomaterials 2022 v.285 pp. 121547
ISSN:
0142-9612
Subject:
amino acids; biocompatible materials; cartilage; chondrogenesis; collagen; gelatin; gelatinase A; ligands; solubility; stem cells
Abstract:
... Targeting stem cells to cartilage lesions has the potential to enhance engraftment and chondrogenesis. Denatured type II collagen fibrils (gelatin) are exposed in lesions at the surface of osteoarthritic articular cartilage and are therefore ideal target sites. We have designed and investigated chimeric mutants of the three modules of the MMP-2 collagen binding domain (CBD) as potential ligands fo ...
DOI:
10.1016/j.biomaterials.2022.121547

32. Dysregulated BMP signaling through ACVR1 impairs digit joint development in fibrodysplasia ossificans progressiva (FOP)

Author:
O. Will Towler; Sun H. Peck; Frederick S. Kaplan; Eileen M. Shore
Source:
Developmental biology 2021 v.470 pp. 136-146
ISSN:
0012-1606
Subject:
abnormal development; bone formation; bone morphogenetic proteins; cartilage; chondrogenesis; embryogenesis; genetic disorders; humans; mice; morphogenesis; mutation; phenotype; skeletal development; skeleton; stem cells
Abstract:
... The development of joints in the mammalian skeleton depends on the precise regulation of multiple interacting signaling pathways including the bone morphogenetic protein (BMP) pathway, a key regulator of joint development, digit patterning, skeletal growth, and chondrogenesis. Mutations in the BMP receptor ACVR1 cause the rare genetic disease fibrodysplasia ossificans progressiva (FOP) in which ex ...
DOI:
10.1016/j.ydbio.2020.11.004

33. Electrospun polycaprolactone/hydroxyapatite/ZnO films as potential biomaterials for application in bone-tendon interface repair

Author:
Xi He; Zongwang Huang; Wenbin Liu; Yanling Liu; Hu Qian; Ting Lei; Long Hua; Yihe Hu; Yi Zhang; Pengfei Lei
Source:
Colloids and surfaces 2021 v.204 pp. 111825
ISSN:
0927-7765
Subject:
biocompatible materials; bone formation; cell adhesion; chondrogenesis; hydroxyapatite; mice; tenocytes
Abstract:
... The bone-tendon interface (BTI) is a graded structure consisting of bone, mineralized and nonmineralized fibrocartilage, and tendons. Due to the complexity of the BTI structure, BTI healing is particularly challenging. To achieve a better material for BTI healing, polycaprolactone (PCL)/hydroxyapatite (HA)/ZnO films were constructed by the electrospinning method; in addition, the relevant material ...
DOI:
10.1016/j.colsurfb.2021.111825

34. Exosome-mediated delivery of kartogenin for chondrogenesis of synovial fluid-derived mesenchymal stem cells and cartilage regeneration

Author:
Xiao Xu; Yujie Liang; Xingfu Li; Kan Ouyang; Manyi Wang; Tong Cao; Wencui Li; Jianquan Liu; Jianyi Xiong; Biquan Li; Jiang Xia; Daping Wang; Li Duan
Source:
Biomaterials 2021 v.269 pp. 120539
ISSN:
0142-9612
Subject:
biocompatible materials; cartilage; chondrocytes; chondrogenesis; cytosol; exosomes; membrane proteins; models; osteoarthritis; peptides; rats; stem cells; therapeutics; water solubility
Abstract:
... Transplantation of synovial fluid-derived mesenchymal stem cells (SF-MSCs) is a viable therapy for cartilage degeneration of osteoarthritis (OA). But controlling chondrogenic differentiation of the transplanted SF-MSCs in the joints remains a challenge. Kartogenin (KGN) is a small molecule that has been discovered to induce differentiation of SF-MSCs to chondrocytes both in vitro and in vivo. The ...
DOI:
10.1016/j.biomaterials.2020.120539

35. Expression Profile of New Gene Markers Involved in Differentiation of Canine Adipose-Derived Stem Cells into Chondrocytes

Author:
Maurycy Jankowski; Mariusz Kaczmarek; Grzegorz Wąsiatycz; Aneta Konwerska; Claudia Dompe; Dorota Bukowska; Paweł Antosik; Paul Mozdziak; Bartosz Kempisty
Source:
Genes 2022 v.13 no.9 pp. -
ISSN:
2073-4425
Subject:
RNA; adipose tissue; cartilage; chondrocytes; chondrogenesis; diabetes; dogs; genes; heart diseases; medicine; models; osteoarthritis; spinal cord; stem cells; stroke; transcriptomics; veterinary clinics
Abstract:
... The interest in stem cell research continuously increased over the last decades, becoming one of the most important trends in the 21st century medicine. Stem cell-based therapies have a potential to become a solution for a range of currently untreatable diseases, such as spinal cord injuries, type I diabetes, Parkinson’s disease, heart disease, stroke, and osteoarthritis. Hence, this study, based ...
DOI:
10.3390/genes13091664

36. Fibrodysplasia Ossificans Progressiva: A Challenging Diagnosis

Author:
Daniele De Brasi; Francesca Orlando; Valeria Gaeta; Maria De Liso; Fabio Acquaviva; Luigi Martemucci; Augusto Mastrominico; Maja Di Rocco
Source:
Genes 2021 v.12 no.8 pp. -
ISSN:
2073-4425
Subject:
abnormal development; adrenal cortex hormones; bone formation; bone morphogenetic proteins; chondrogenesis; genes; heterozygosity; inflammation; phenotype; skeleton
Abstract:
... Fibrodysplasia ossificans progressiva (FOP) is an ultrarare genetic condition characterized by extraskeletal bone formation. Most of the musculoskeletal characteristics of FOP are related to dysregulated chondrogenesis, with heterotopic ossification being the most typical feature. Activating mutations of activin receptor A type I (ACVR1), a bone morphogenetic protein (BMP) type I receptor, are res ...
DOI:
10.3390/genes12081187

37. FoxO3a cooperates with RUNX1 to promote chondrogenesis and terminal hypertrophic of the chondrogenic progenitor cells

Author:
Shun Yuan; Lang Zhang; Lianru Ji; Sufang Zhong; Liyun Jiang; Yang Wan; Yonggui Song; Changhua Zhang; Rikang Wang
Source:
Biochemical and biophysical research communications 2022 v.589 pp. 41-47
ISSN:
0006-291X
Subject:
cartilage; chondrocytes; chondrogenesis; homeostasis; immunohistochemistry; neonates; osteoarthritis; osteoblasts; precipitin tests; research; therapeutics; transcription factors
Abstract:
... FoxO transcription factors (FoxOs) have recently been shown to protect against chondrocyte dysfunction and modulate cartilage homeostasis in osteoarthritis. The mechanism underlying of FoxOs regulate chondrocyte differentiation remains unknown. Runt related transcription factor 1 (RUNX1) mediated both chondrocyte and osteoblast differentiation. Our data showed that FoxO3a and RUNX1 are co-expresse ...
DOI:
10.1016/j.bbrc.2021.12.008

38. Genistein inhibits chondrogenic differentiation and mineralization of ATDC5 cells

Author:
Aya Kitagawa; Mana Yamaguchi; Aki Fujiwara; Muneshige Shimizu; Azusa Takahashi; Hideyuki Sone; Shin Kamiyama
Source:
Biochemical and biophysical research communications 2021 v.566 pp. 123-128
ISSN:
0006-291X
Subject:
Fabaceae; calcification; calcium; chondrogenesis; collagen; daidzein; genistein; mineralization; plant estrogens; proteoglycans; research
Abstract:
... Isoflavones are phytoestrogens abundant in leguminous crops and are used to prevent a variety of hormonal disorders. In the present study, the effects of genistein and daidzein on the chondrogenic differentiation of ATDC5 cells were investigated. Genistein (10 μM) treatment markedly reduced production of sulfated proteoglycans and collagen fibers in the ATDC5 cells. Genistein suppressed the expres ...
DOI:
10.1016/j.bbrc.2021.05.101

39. Highly effective rheumatoid arthritis therapy by peptide-promoted nanomodification of mesenchymal stem cells

Author:
Yao Lu; Zhan Li; Lihua Li; Jieli Chen; Xingyi Xu; Zefeng Lin; Tao Zhang; Ye Zhu; Changhai Ding; Chuanbin Mao
Source:
Biomaterials 2022 v.283 pp. 121474
ISSN:
0142-9612
Subject:
biocompatible materials; cartilage; catalase; cell movement; chondrogenesis; inflammation; intravenous injection; metformin; oxidation; peptides; rats; rheumatoid arthritis; stem cells; superoxide dismutase
Abstract:
... Traditional medication is not satisfied in rheumatoid arthritis (RA) therapy due to its long-term side effects and failure in cartilage repair. Nanomodification of mesenchymal stem cells (MSCs) holds promise for lifting such hurdles but delivering therapeutic nanomaterials (NPs) into MSCs remains challenging in this new strategy. Here, we show that CuS@MnO₂ NPs functionalized with a short phage-se ...
DOI:
10.1016/j.biomaterials.2022.121474

40. In situ biomimetic lyotropic liquid crystal gel for full-thickness cartilage defect regeneration

Author:
Hui Wang; Tingting Peng; Haofeng Wu; Jintian Chen; Minglong Chen; Liling Mei; Feng Li; Wenhao Wang; Chuanbin Wu; Xin Pan
Source:
Journal of controlled release 2021 v.338 pp. 623-632
ISSN:
0168-3659
Subject:
biomimetics; bones; cartilage; chondrogenesis; drug delivery systems; drugs; gels; histology; liquid crystals; lubrication; micro-computed tomography; pharmacodynamics; strength (mechanics)
Abstract:
... There is a great challenge in regenerating cartilage defects, which usually involve absent bearing capacity and poor adaptation to joint movement, further exacerbating subchondral bone damage. Therefore, ideal tissue-engineering cartilage scaffolds should be endowed with biomimetic and sustained-release function for promoting long-term chondrogenesis while protecting subchondral bone. Herein, in s ...
DOI:
10.1016/j.jconrel.2021.08.062

41. Integrated analysis of miRNA and mRNA transcriptomic reveals antler growth regulatory network

Author:
Boyin Jia; Linlin Zhang; Yifan Zhang; Chenxia Ge; Fuhe Yang; Rui Du; Hengxing Ba
Source:
Molecular genetics and genomics 2021 v.296 no.3 pp. 689-703
ISSN:
1617-4615
Subject:
bone formation; carcinogenesis; chondrogenesis; fibroblast growth factor receptor 1; genomics; microRNA; sequence analysis; transcriptomics; unigenes
Abstract:
... The growth of antler is driven by endochondral ossification in the growth center of the apical region. Antler grows faster than cancer tissues, but it can be stably regulated and regenerated periodically. To elucidate the molecular mechanisms of how antler grows rapidly without carcinogenesis, in this study, we used RNA-seq technology to evaluate the changes of miRNA and mRNA profiles in antler at ...
DOI:
10.1007/s00438-021-01776-z

42. Jellyfish Collagen: A Biocompatible Collagen Source for 3D Scaffold Fabrication and Enhanced Chondrogenicity

Author:
Zara Ahmed; Lydia C. Powell; Navid Matin; Andrew Mearns-Spragg; Catherine A. Thornton; Ilyas M. Khan; Lewis W. Francis
Source:
Marine drugs 2021 v.19 no.8 pp. -
ISSN:
1660-3397
Subject:
Rhizostoma; biocompatibility; biocompatible materials; bovine spongiform encephalopathy; cartilage; cattle; cell death; chondrogenesis; collagen; cytokines; extracellular matrix; histology; leukocytes; medicine; morbidity; osteoarthritis; strength (mechanics); swine
Abstract:
... Osteoarthritis (OA) is a multifactorial disease leading to degeneration of articular cartilage, causing morbidity in approximately 8.5 million of the UK population. As the dense extracellular matrix of articular cartilage is primarily composed of collagen, cartilage repair strategies have exploited the biocompatibility and mechanical strength of bovine and porcine collagen to produce robust scaffo ...
DOI:
10.3390/md19080405

43. Lizard Blastema Organoid Model Recapitulates Regenerated Tail Chondrogenesis

Author:
Ariel C. Vonk; Sarah C. Hasel-Kolossa; Gabriela A. Lopez; Megan L. Hudnall; Darian J. Gamble; Thomas P. Lozito
Source:
Journal of developmental biology 2022 v.10 no.1 pp. -
ISSN:
2221-3759
Subject:
Anolis carolinensis; Erinaceidae; cartilage; chondrogenesis; collagenase; dissociation; histology; hybridization; lizards; models; organoids; tail; tissue repair
Abstract:
... (1) Background: Lizard tail regeneration provides a unique model of blastema-based tissue regeneration for large-scale appendage replacement in amniotes. Green anole lizard (Anolis carolinensis) blastemas contain fibroblastic connective tissue cells (FCTCs), which respond to hedgehog signaling to create cartilage in vivo. However, an in vitro model of the blastema has not previously been achieved ...
DOI:
10.3390/jdb10010012

44. Long-term dynamic compression enhancement TGF-β3-induced chondrogenesis in bovine stem cells: a gene expression analysis

Author:
Jishizhan Chen; Lidan Chen; Jia Hua; Wenhui Song
Source:
BMC genomic data 2021 v.22 no.1 pp. 13
ISSN:
2730-6844
Subject:
Toll-like receptors; bioinformatics; cartilage; cattle; chondrogenesis; computer software; data collection; gene expression; gene expression regulation; gene ontology; genes; genomics; interleukin-6; protein-protein interactions; sensation
Abstract:
... BACKGROUND: Bioengineering has demonstrated the potential of utilising mesenchymal stem cells (MSCs), growth factors, and mechanical stimuli to treat cartilage defects. However, the underlying genes and pathways are largely unclear. This is the first study on screening and identifying the hub genes involved in mechanically enhanced chondrogenesis and their potential molecular mechanisms. METHODS: ...
DOI:
10.1186/s12863-021-00967-2

45. Oct4 facilitates chondrogenic differentiation of mesenchymal stem cells by mediating CIP2A expression

Author:
Lexiang Li; Qiwei Fu; Jiahua Shao; Bo Wang; Zheru Ding; Shuai Yuan; Jinhui Peng; Wei Xin; Jun Zhu; Yi Chen
Source:
Cell and tissue research 2022 v.389 no.1 pp. 11-21
ISSN:
0302-766X
Subject:
cartilage; chondrogenesis; gene expression regulation; microarray technology; phosphoprotein phosphatase; phosphorylation; quantitative polymerase chain reaction; research; skeletal development; transcription factors
Abstract:
... Bone development and cartilage formation require strict modulation of gene expression for mesenchymal stem cells (MSCs) to progress through their differentiation stages. Octamer-binding transcription factor 4 (Oct4) expression is generally restricted to developing embryonic pluripotent cells, but its role in chondrogenic differentiation (CD) of MSCs remains unclear. We therefore investigated the r ...
DOI:
10.1007/s00441-022-03619-8

46. Pharmaceutical therapeutics for articular regeneration and restoration: state-of-the-art technology for screening small molecular drugs

Author:
Yishan Chen; Heng Sun; Xudong Yao; Yeke Yu; Tian Tian; Weiyang Xu; Yujie Zhou; Hongwei Ouyang
Source:
Cellular and molecular life sciences 2021 v.78 no.24 pp. 8127-8155
ISSN:
1420-682X
Subject:
cartilage; chondrocytes; chondrogenesis; cost effectiveness; disease progression; epigenetics; inflammation; metabolism; osteoarthritis; phenotype; therapeutics
Abstract:
... Articular cartilage damage caused by sports injury or osteoarthritis (OA) has gained increased attention as a worldwide health burden. Pharmaceutical treatments are considered cost-effective means of promoting cartilage regeneration, but are limited by their inability to generate sufficient functional chondrocytes and modify disease progression. Small molecular chemical compounds are an abundant s ...
DOI:
10.1007/s00018-021-03983-8

47. Protein-reactive nanofibrils decorated with cartilage-derived decellularized extracellular matrix for osteochondral defects

Author:
Hye Sung Kim; Nandin Mandakhbayar; Hae-Won Kim; Kam W. Leong; Hyuk Sang Yoo
Source:
Biomaterials 2021 v.269 pp. 120214
ISSN:
0142-9612
Subject:
biocompatible materials; cartilage; cattle; chondrogenesis; epoxides; extracellular matrix; genes; mesenchymal stromal cells; nanofibers; polymerization; polymers; texture
Abstract:
... Cartilage defect is difficult to heal due to its avascular properties. Implantation of mesenchymal stem cell is one of the most promising approach for regenerating cartilage defects. Here we prepared polymeric nanofibrils decorated with cartilage-derived decellularized extracellular matrix (dECM) as a chondroinductive scaffold material for cartilage repair. To fabricate nanofibrils, eletrospun PCL ...
DOI:
10.1016/j.biomaterials.2020.120214

48. Single-cell profiles of human bone marrow-derived mesenchymal stromal cells after IFN-γ and TNF-α licensing

Author:
Shuanglong Lu; Xiaohong Qiao
Source:
Gene 2021 v.771 pp. 145347
ISSN:
0378-1119
Subject:
adipogenesis; bone formation; cell cycle; chemokines; chondrogenesis; gene expression; genes; genetic markers; humans; mesenchymal stromal cells; sequence analysis
Abstract:
... Pre-licensing mesenchymal stromal cells (MSCs) with IFN-γ and TNF-α can empower their immune fate and induce a more effective immune regulation. However, the cellular heterogeneity of MSCs limits our understanding of this inflammatory licensing.The publicly available Gene Expression Omnibus single-cell RNA sequencing (scRNA-seq) data of human bone marrow-derived MSCs with or without IFN-γ and TNF- ...
DOI:
10.1016/j.gene.2020.145347

49. Spatial organization of biochemical cues in 3D-printed scaffolds to guide osteochondral tissue engineering

Author:
Paula Camacho; Anne Behre; Matthew Fainor; Kelly B. Seims; Lesley W. Chow
Source:
Biomaterials science 2021 v.9 no.20 pp. 6813-6829
ISSN:
2047-4849
Subject:
biocompatible materials; bone formation; cartilage; chondrocytes; chondrogenesis; humans; hyaluronic acid; peptides; synergism; tissue repair
Abstract:
... Functional repair of osteochondral (OC) tissue remains challenging because the transition from bone to cartilage presents gradients in biochemical and physical properties necessary for joint function. Osteochondral regeneration requires strategies that restore the spatial composition and organization found in the native tissue. Several biomaterial approaches have been developed to guide chondrogen ...
DOI:
10.1039/d1bm00859e

50. Substrate stiffness and sequence dependent bioactive peptide hydrogels influence the chondrogenic differentiation of human mesenchymal stem cells

Author:
Mohiuddin Mohammed; Tsung-Sheng Lai; Hsin-Chieh Lin
Source:
Journal of materials chemistry B 2021 v.9 no.6 pp. 1676-1685
ISSN:
2050-7518
Subject:
amino acid sequences; cadherins; cartilage; cell culture; cell differentiation; chondrogenesis; glycoproteins; glycosaminoglycans; humans; hydrogels; nanofibers; pH; peptides; serine; stem cells
Abstract:
... N-Cadherin is a transmembrane glycoprotein that plays a crucial role in the condensation of mesenchymal cells by enhancing cell–cell interactions during the process of chondrogenesis. The biophysical and biochemical signals can incite enhanced cell–cell contact which ultimately determines the fate of stem cells. The role of cadherin mimetic peptides on the differentiation of mesenchymal stem cells ...
DOI:
10.1039/d0tb02008g