U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Subject curcumin Remove constraint Subject: curcumin Subject animal models Remove constraint Subject: animal models Subject term Curcuma longa Remove constraint Subject term: Curcuma longa Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
Start Over

Search

19  Search Results

1 - 19 of 19
Number of results to display per page

Search Results

1. Gelatin-lecithin-F127 gel mediated self-assembly of curcumin vesicles for enhanced wound healing

Author:
Ram Pada Das; Vishwa V. Gandhi; Gunjan Verma; Juby K. Ajish; Beena G. Singh; Amit Kunwar
Source:
International journal of biological macromolecules 2022 v.210 pp. 403-414
ISSN:
0141-8130
Subject:
Curcuma longa; absorption; animal models; bioavailability; collagen; curcumin; gel strength; gelatin; gelation; histopathology; hydrophobicity; lecithins; porosity; solubility; solvents; storage modulus; temperature
Abstract:
... Curcumin, a principal component of Curcuma longa, has a long history of being used topically for wound healing. However, poor aqueous solubility of curcumin leads to poor topical absorption. Recently, gelatin based gel has been reported to overcome this issue. However, the release of curcumin from gelatin gel in the bioavailable or easily absorbable form is still a challenge. The present study rep ...
DOI:
10.1016/j.ijbiomac.2022.04.134

2. The Multifaced Actions of Curcumin in Pregnancy Outcome

Author:
Giovanni Tossetta; Sonia Fantone; Stefano Raffaele Giannubilo; Daniela Marzioni
Source:
Antioxidants 2021 v.10 no.1 pp. -
ISSN:
2076-3921
Subject:
Curcuma longa; adverse effects; animal models; anti-inflammatory agents; antioxidants; arthritis; clinical trials; curcumin; fetal development; gestational diabetes; human nutrition; humans; pathogenesis; pathogens; pre-eclampsia; pregnancy outcome; premature birth; rhizomes; toxicity
Abstract:
... Curcumin, also known as diferuloylmethane, is the main polyphenolic substance present in the rhizomes of Curcuma longa L. This plant showed many beneficial effects and has been used since ancient times for both food and pharmaceutical purposes. Due to its pleiotropic functions, curcumin consumption in the human diet has become very common thanks also to the fact that this natural compound is consi ...
DOI:
10.3390/antiox10010126

3. Calebin-A induced death of malignant peripheral nerve sheath tumor cells by activation of histone acetyltransferase

Author:
Ming-Jen Lee; Yi-Jane Tsai; May-Yao Lin; Huey-Ling You; Nagabhushanam Kalyanam; Chi-Tang Ho; Min-Hsiung Pan
Source:
Phytomedicine 2019 v.57 pp. 377-384
ISSN:
0944-7113
Subject:
Curcuma longa; DNA; Western blotting; analytical kits; animal models; curcumin; death; dose response; drug therapy; epigallocatechin gallate; epigenetics; flow cytometry; genes; histone acetyltransferase; histones; in vivo studies; interphase; neoplasm cells; neoplasms; pro-apoptotic proteins; quantitative polymerase chain reaction; signal transduction; turmeric
Abstract:
... Neurofibromatosis type 1 (NF1) is one of the most common hereditary neurocutaneous disorders. The malignant peripheral nerve sheath tumor (MPNST), transformed from NF1 related plexiform neurofibroma, is a rapidly growing and highly invasive tumor. No effective chemotherapeutic agent is currently available. Calebin-A is a derivative from turmeric Curcuma longa. Given the anti-inflammatory and antic ...
DOI:
10.1016/j.phymed.2019.01.001

4. Combinational effect of curcumin and metformin against gentamicin‐induced nephrotoxicity: Involvement of antioxidative, anti‐inflammatory and antiapoptotic pathway

Author:
Liying Cao; Dongyun Zhi; Jing Han; Sushil Kumar Sah; Yunhui Xie
Source:
Journal of food biochemistry 2019 v.43 no.7 pp. e12836
ISSN:
0145-8884
Subject:
Curcuma longa; Gram-negative bacteria; animal models; antioxidant enzymes; apoptosis; bacterial infections; caspase-3; curcumin; diabetes mellitus; gentamicin; inflammation; interleukin-6; kidney cells; kidneys; metabolites; metformin; nephrotoxicity; oxidative stress; signal transduction; synergism; tumor necrosis factor-alpha
Abstract:
... Gentamicin (GM) is an antibiotic related to aminoglycoside group that is used in treating Gram‐negative bacterial infections. However, treatment with gentamicin is considered to be limited as it induces an oxidative stress‐mediated apoptosis in kidney which causes a nephrotoxicity. Metformin is a well‐known biguanide that is used for treating diabetes mellitus, especially type 2. Supplement with p ...
DOI:
10.1111/jfbc.12836

5. Curcumin stimulates exosome/microvesicle release in an in vitro model of intracellular lipid accumulation by increasing ceramide synthesis

Author:
David García-Seisdedos; Bohdan Babiy; Milagros Lerma; María E. Casado; Javier Martínez-Botas; Miguel A. Lasunción; Óscar Pastor; Rebeca Busto
Source:
Biochimica et biophysica acta 2020 v.1865 no.5 pp. 158638
ISSN:
1388-1981
Subject:
Curcuma longa; animal models; ceramides; curcumin; enzyme inhibitors; exosomes; fumonisin B1; hydrophobicity; mice; neuroglia; polyphenols; rhizomes; secretion; serine C-palmitoyltransferase; sphingosine N-acyltransferase
Abstract:
... Curcumin, a hydrophobic polyphenol found in the rhizome of Curcuma longa, has been shown to reduce intracellular lipid accumulation in mouse models of lysosomal storage diseases such as Niemann-Pick type C. Exosomes are small extracellular vesicles secreted by cells in response to changes in intracellular ceramide composition. Curcumin can induce exosome/microvesicle release in cellular models of ...
DOI:
10.1016/j.bbalip.2020.158638

6. Curcumin: Could This Compound Be Useful in Pregnancy and Pregnancy-Related Complications?

Author:
Tiziana Filardi; Rosaria Varì; Elisabetta Ferretti; Alessandra Zicari; Susanna Morano; Carmela Santangelo
Source:
Nutrients 2020 v.12 no.10 pp. -
ISSN:
2072-6643
Subject:
Curcuma longa; administrative management; adverse effects; animal models; antioxidants; chronic diseases; curcumin; fetal development; functional foods; gestational diabetes; growth disorders; humans; in vitro studies; information; light; medicine; nutrients; pathophysiology; polyphenols; pre-eclampsia; pregnancy outcome; premature birth; tissues; turmeric
Abstract:
... Curcumin, the main polyphenol contained in turmeric root (Curcuma longa), has played a significant role in medicine for centuries. The growing interest in plant-derived substances has led to increased consumption of them also in pregnancy. The pleiotropic and multi-targeting actions of curcumin have made it very attractive as a health-promoting compound. In spite of the beneficial effects observed ...
DOI:
10.3390/nu12103179

7. Curcumin Plays Neuroprotection Activity by Modulation of Neurotrophic Factor BDNF, GAP-43 and GFAP in Mice with Traumatic Brain Injury (P06-043-19)

Author:
Nurhan Sahin; Ertugrul Kilic; Nilay Ates; Zeynep Balcikanli; Cemal Orhan; Mehmet Tuzcu; Kazim Sahin; Vijaya Juturu
Source:
Current developments in nutrition 2019 v.3 no.Supplement_1 pp. -
ISSN:
2475-2991
Subject:
Curcuma longa; animal models; brain; brain damage; cell adhesion molecules; cold; curcumin; infarction; interleukin-1beta; interleukin-6; intraperitoneal injection; males; mice; neuroprotective effect; rhizomes; transcription factor NF-kappa B
Abstract:
... Curcumin, extracted from the rhizome Curcuma longa, has been shown to be beneficial for neuroprotection in previous studies. In a recent study, a novel formulation of curcumin resulted in an increased relative absorption by 46 times (CurcuWIN®) of the total curcuminoids over the unformulated standard curcumin form. However, the exact mechanisms by which curcumin demonstrates its neuroprotective ef ...
DOI:
10.1093/cdn/nzz031.P06-043-19

8. A combined omics approach to evaluate the effects of dietary curcumin on colon inflammation in the Mdr1a−/− mouse model of inflammatory bowel disease

Author:
Janine M. Cooney; Matthew P.G. Barnett; Yvonne E.M. Dommels; Diane Brewster; Christine A. Butts; Warren C. McNabb; William A. Laing; Nicole C. Roy
Source:
Journal of nutritional biochemistry 2016 v.27 pp. 181-192
ISSN:
0955-2863
Subject:
animal models; anti-inflammatory activity; colon; curcumin; diet; gene expression regulation; humans; immune response; inflammation; inflammatory bowel disease; messenger RNA; mice; microarray technology; mitogen-activated protein kinase; neutrophils; nutritional intervention; phosphatidylinositol 3-kinase; protein synthesis; proteomics; transcription factors; transcriptomics; two-dimensional gel electrophoresis
Abstract:
... The aim of this study was to provide insight into how curcumin reduces colon inflammation in the Mdr1a⁻/⁻ mouse model of human inflammatory bowel disease using a combined transcriptomics and proteomics approach. Mdr1a⁻/⁻ and FVB control mice were randomly assigned to an AIN-76A (control) diet or AIN-76A+0.2% curcumin. At 21 or 24weeks of age, colonic histological injury score (HIS) was determined, ...
DOI:
10.1016/j.jnutbio.2015.08.030

9. Turmeric (Curcuma longa) attenuates food allergy symptoms by regulating type 1/type 2 helper T cells (Th1/Th2) balance in a mouse model of food allergy

Author:
Hee Soon Shin; Hye-Jeong See; Sun Young Jung; Dae Woon Choi; Da-Ae Kwon; Min-Jung Bae; Ki-Seung Sung; Dong-Hwa Shon
Source:
Journal of ethnopharmacology 2015 v.175 pp. 21-29
ISSN:
0378-8741
Subject:
Curcuma longa; alum; anaphylaxis; animal models; anti-allergic agents; arthritis; asthma; atopic dermatitis; bronchitis; curcumin; cytokines; diarrhea; fever; food allergies; immune response; immunoglobulin E; immunoglobulin G; mast cells; mice; ovalbumin; pain; traditional medicine; turmeric
Abstract:
... Turmeric (Curcuma longa) has traditionally been used to treat pain, fever, allergic and inflammatory diseases such as bronchitis, arthritis, and dermatitis. In particular, turmeric and its active component, curcumin, were effective in ameliorating immune disorders including allergies. However, the effects of turmeric and curcumin have not yet been tested on food allergies.Mice were immunized with ...
DOI:
10.1016/j.jep.2015.08.038

10. Characteristics of curcumin-loaded poly (lactic acid) nanofibers for wound healing

Author:
Thuy Thi Thu Nguyen; Chiranjit Ghosh; Seong-Gu Hwang; Lam Dai Tran; Jun Seo Park
Source:
Journal of materials science 2013 v.48 no.20 pp. 7125-7133
ISSN:
0022-2461
Subject:
Curcuma longa; animal models; anti-inflammatory activity; curcumin; functional properties; lactic acid; nanofibers; porosity; surface area; tissue repair
Abstract:
... Curcumin (Cur) is a well-known extract of the root of Curcuma longa L. that has multi biological functions such as anti-oxidation, anti-inflammatory, anti-cancer, and wound healing properties. In the present study, poly (lactic acid) (PLA) nanofibers were used as a carrier for Cur because PLA nanofibers are biocompatible and have a high-specific surface area and high porosity, which can enhance th ...
DOI:
10.1007/s10853-013-7527-y

11. New mechanisms and the anti-inflammatory role of curcumin in obesity and obesity-related metabolic diseases

Author:
Shehzad, Adeeb; Ha, Taewook; Subhan, Fazli; Lee, Young Sup
Source:
European journal of nutrition 2011 v.50 no.3 pp. 151-161
ISSN:
1436-6207
Subject:
herbs; anti-inflammatory activity; adiponectin; hyperlipidemia; leptin; resistin; signal transduction; noninsulin-dependent diabetes mellitus; obesity; risk; languages; macrophages; cytokines; human health; Curcuma longa; insulin resistance; obesity-related diseases; hyperglycemia; transcription factors; cell culture; myocytes; disease outbreaks; chronic diseases; curcumin; clinical trials; experimental design; hypertension; healthy diet; animal models
Abstract:
... Purpose A metabolic abnormality such as obesity is a major obstacle in the maintenance of the human health system and causes various chronic diseases including type 2 diabetes, hypertension, cardiovascular diseases, as well as various cancers. This study was designed to summarize the recent scientific knowledge regarding the anti-obesity role of curcumin (diferuloylmethane), which is isolated from ...
DOI:
10.1007/s00394-011-0188-1
PubMed:
21442412

12. A validated method for the quantification of curcumin in plasma and brain tissue by fast narrow-bore high-performance liquid chromatography with fluorescence detection

Author:
Schiborr, Christina; Eckert, Gunter P.; Rimbach, Gerald; Frank, Jan
Source:
Analytical and bioanalytical chemistry 2010 v.397 no.5 pp. 1917-1925
ISSN:
1618-2642
Subject:
Alzheimer disease; Curcuma longa; acetic acid; acetonitrile; animal models; brain; curcumin; detection limit; ethyl acetate; fluorescence; high performance liquid chromatography; human diseases; methanol; mice; polyphenols; rhizomes; turmeric; water
Abstract:
... Curcumin, a lipophilic polyphenol derived from the rhizome of the plant turmeric (Curcuma longa), might be useful in the prevention and treatment of a number of degenerative brain disorders, including glioma multiforma and Alzheimer's disease. Thus, there is growing interest in measuring curcumin concentrations in the brain and other target tissues in relevant animal models. We therefore developed ...
DOI:
10.1007/s00216-010-3719-3
PubMed:
20419505

13. Curcumin prevents oxidative renal damage induced by acetaminophen in rats

Author:
Cekmen, M.; Ilbey, Y.O.; Ozbek, E.; Simsek, A.; Somay, A.; Ersoz, C.
Source:
Food and chemical toxicology 2009 v.47 no.7 pp. 1480-1484
ISSN:
0278-6915
Subject:
curcumin; Curcuma longa; medicinal properties; antioxidants; protective effect; oxidative stress; nephrotoxins; acetaminophen; drug toxicity; nephrotoxicity; biochemical mechanisms; animal models; rats; antioxidant activity; enzyme activity; malondialdehyde; glutathione; kidneys; renal function; histopathology
DOI:
10.1016/j.fct.2009.03.034
PubMed:
19345714

14. The Role of Curcuma longa Against Doxorubicin (Adriamycin)-Induced Toxicity in Rats

Author:
Mohamad, Ragaa Hosny; El-Bastawesy, Amal Mohamad; Zekry, Zekry Khalid; Al-Mehdar, Hussain A.; Al-said, Mohamad Gamil Abdel Monaam; Aly, Soaad Shaker; Sharawy, Sabry Mohamed; El-Merzabani, Mahmuod M.
Source:
Journal of medicinal food 2009 v.12 no.2 pp. 394-402
ISSN:
1096-620X
Subject:
urine; medicinal plants; biomarkers; Curcuma longa; lactate dehydrogenase; hepatoprotective effect; blood lipids; body weight; turmeric; rats; curcumin; antioxidant activity; antioxidants; doxorubicin; creatine kinase; cholesterol; animal models; cardiovascular system; nephrotoxicity; hepatotoxicity
DOI:
10.1089/jmf.2007.0715
PubMed:
19459743

15. Anticancer properties of panduratin A isolated from Boesenbergia pandurata (Zingiberaceae)

Author:
Chandra Kirana; Graham Peter Jones; Ian Roland Record; Graeme Howie McIntosh
Source:
Natural medicines 2007 v.61 no.2 pp. 131-137
ISSN:
1340-3443
Subject:
Curcuma longa; Kaempferia; adenocarcinoma; animal models; antineoplastic agents; apoptosis; azoxymethane; body weight; breast neoplasms; chalcone; clinical trials; colon; colorectal neoplasms; curcumin; diet; dose response; humans; in vivo studies; ingredients; inhibitory concentration 50; interphase; males; neoplasm cells; propidium; protective effect; rats; rhizomes; toxicity; women; Indonesia
Abstract:
... Extract of Boesenbergia pandurata (Kaempferia pandurata) (Zingiberaceae) has been used as a replacement for K. rotunda, the main ingredient of a popular traditional tonic called “jamu” especially for women in Indonesia. From our previous study, ethanolic extract of B. pandurata showed strong inhibitory effects on the growth of cancer cells, similar to ethanolic extract of Curcuma longa. C. longa a ...
DOI:
10.1007/s11418-006-0100-0

16. Influence of tetrahydrocurcumin on erythrocyte membrane bound enzymes and antioxidant status in experimental type 2 diabetic rats

Author:
Murugan, P.; Pari, L.
Source:
Journal of ethnopharmacology 2007 v.113 no.3 pp. 479-486
ISSN:
0378-8741
Subject:
pancreas; Ca2-transporting ATPase; medicinal plants; cell membranes; glutathione; glutathione transferase; Curcuma longa; adenosinetriphosphatase; human diseases; superoxide dismutase; blood glucose; insulin; diabetes; curcumin; antioxidant activity; enzyme activity; rats; thiobarbituric acid-reactive substances; catalase; hemoglobin; erythrocytes; glutathione peroxidase; animal models
DOI:
10.1016/j.jep.2007.07.004

17. A two generation reproductive toxicity study with curcumin, turmeric yellow, in Wistar rats

Author:
Ganiger, S.; Malleshappa, H.N.; Krishnappa, H.; Rajashekhar, G.; Rao, V.R.; Sullivan, F.
Source:
Food and chemical toxicology 2007 v.45 no.1 pp. 64-69
ISSN:
0278-6915
Subject:
curcumin; turmeric; Curcuma longa; toxicity testing; safety testing; fetotoxicity; teratogenicity; genotoxicity; rats; animal models; maternal nutrition; experimental diets; dosage; adverse effects; progeny; pups; histopathology; signs and symptoms (animals and humans); mortality; weight gain; flavorings; chemical constituents of plants
DOI:
10.1016/j.fct.2006.07.016
PubMed:
16987575

18. Antitumor Activity of Extract of Zingiber aromaticum and Its Bioactive Sesquiterpenoid Zerumbone

Author:
Kirana, Chandra; McIntosh, Graeme H.; Record, Ian R.; Jones, Graham P.
Source:
Nutrition and cancer 2003 v.45 no.2 pp. 218-225
ISSN:
0163-5581
Subject:
Curcuma longa; Zingiber; animal models; anticarcinogenic activity; antineoplastic agents; apoptosis; azoxymethane; body weight; cell cycle; colon; colorectal neoplasms; curcumin; diet; inhibitory concentration 50; rats; rhizomes; tetrazolium
Abstract:
... The anticancer properties of zerumbone (2,6,9 humulatriene-8-one, a sesquiterpenoid) from Zingiber aromaticum were compared with those of curcumin from Curcuma longa in an in vitro MTT tetrazolium salt assay using HT-29, CaCo-2, and MCF-7 cancer cells and in an azoxymethane (AOM)-induced animal model of colon cancer using aberrant crypt foci (ACFs) as a preneoplastic marker. The IC50 of zerumbone ...
DOI:
10.1207/S15327914NC4502_12
PubMed:
12881017

19. Effects of curcumin on cyclosporine-induced cholestasis and hypercholesterolemia and on cyclosporine metabolism in the rat

Author:
Deters, M.; Klabunde, T.; Meyer, H.; Resch, K.; Kaever, V.
Source:
Planta medica 2003 v.69 no.4 pp. 337-343
ISSN:
0032-0943
Subject:
Curcuma longa; medicinal plants; plant extracts; chemical constituents of plants; curcumin; bioactive properties; cyclosporins; protein metabolism; cholestasis; hypercholesterolemia; rats; animal models; chemical structure; bile salts; cholesterol; bilirubin; metabolites; bile ducts; blood serum; lipid content; body weight; triacylglycerols
DOI:
10.1055/s-2003-38870
PubMed:
12709901