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1. Curcumin stimulates exosome/microvesicle release in an in vitro model of intracellular lipid accumulation by increasing ceramide synthesis

Author:
David García-Seisdedos; Bohdan Babiy; Milagros Lerma; María E. Casado; Javier Martínez-Botas; Miguel A. Lasunción; Óscar Pastor; Rebeca Busto
Source:
Biochimica et biophysica acta 2020 v.1865 no.5 pp. 158638
ISSN:
1388-1981
Subject:
Curcuma longa; animal models; ceramides; curcumin; enzyme inhibitors; exosomes; fumonisin B1; hydrophobicity; mice; neuroglia; polyphenols; rhizomes; secretion; serine C-palmitoyltransferase; sphingosine N-acyltransferase
Abstract:
... Curcumin, a hydrophobic polyphenol found in the rhizome of Curcuma longa, has been shown to reduce intracellular lipid accumulation in mouse models of lysosomal storage diseases such as Niemann-Pick type C. Exosomes are small extracellular vesicles secreted by cells in response to changes in intracellular ceramide composition. Curcumin can induce exosome/microvesicle release in cellular models of ...
DOI:
10.1016/j.bbalip.2020.158638