Subject: curcumin / Subject term: ceramides / Text availability: Citation in PubAg / Text Availability: Citation in PubAg

Author:: David García-Seisdedos; Bohdan Babiy; Milagros Lerma; María E. Casado; Javier Martínez-Botas; Miguel A. Lasunción; Óscar Pastor; Rebeca Busto
Source:: Biochimica et biophysica acta 2020 v.1865 no.5 pp. 158638
ISSN:: 1388-1981
Subject:: Curcuma longa; animal models; ceramides; curcumin; enzyme inhibitors; exosomes; fumonisin B1; hydrophobicity; mice; neuroglia; polyphenols; rhizomes; secretion; serine C-palmitoyltransferase; sphingosine N-acyltransferase
Abstract:: ... Curcumin, a hydrophobic polyphenol found in the rhizome of Curcuma longa, has been shown to reduce intracellular lipid accumulation in mouse models of lysosomal storage diseases such as Niemann-Pick type C. Exosomes are small extracellular vesicles secreted by cells in response to changes in intracellular ceramide composition. Curcumin can induce exosome/microvesicle release in cellular models of ...
DOI:: 10.1016/j.bbalip.2020.158638
: https://doi.org/10.1016/j.bbalip.2020.158638

Author:: Abo Bakr Abdel Shakor; Mona Atia; Ismail Ahmed Ismail; Ali Alshehri; Hesham El-Refaey; Katarzyna Kwiatkowska; Andrzej Sobota
Source:: BBA - Molecular and Cell Biology of Lipids 2014 v.1841 pp. 1672-1682
ISSN:: 1388-1981
Subject:: P-glycoproteins; antineoplastic agents; apoptosis; caspase-3; cell viability; ceramides; curcumin; cyclosporine; genes; humans; leukemia; multiple drug resistance; neoplasm cells; sphingomyelins
Abstract:: ... Most anti-cancer agents induce apoptosis, however, a development of multidrug resistance in cancer cells and defects in apoptosis contribute often to treatment failure. Here, the mechanism of curcumin-induced apoptosis was investigated in human leukemia HL60 cells and their HL60/VCR multidrug-resistant counterparts. In both cell lines curcumin induced a bi-phasic ceramide generation with a slow ph ...
DOI:: 10.1016/j.bbalip.2014.09.006
: https://doi.org/10.1016/j.bbalip.2014.09.006

Author:: Ying Qiu; Teng Yu; Wei Wang; Kun Pan; Dongmei Shi; Hui Sun
Source:: Biochemical and biophysical research communications 2014 v.448 pp. 15-21
ISSN:: 0006-291X
Subject:: apoptosis; ceramides; curcumin; cyclosporine; cytochrome c; cytotoxicity; melanoma; membrane potential; mitochondria; mitochondrial membrane; permeability; small interfering RNA
Abstract:: ... Here we studied the role of mitochondrial permeability transition pore (mPTP) opening in curcumin’s cytotoxicity in melanoma cells. In cultured WM-115 melanoma cells, curcumin induced mitochondrial membrane potential (MPP) decrease, cyclophilin-D (CyPD)-adenine nucleotide translocator 1 (ANT-1) (two mPTP components) mitochondrial association and cytochrome C release, indicating mPTP opening. The m ...
DOI:: 10.1016/j.bbrc.2014.04.024
: https://doi.org/10.1016/j.bbrc.2014.04.024

Author:: Sindhu Thangavel; Toru Yoshitomi; Meena Kishore Sakharkar; Yukio Nagasaki
Source:: Journal of Controlled Release 2015 v.209 pp. 110-119
ISSN:: 0168-3659
Subject:: apoptosis; caspases; ceramides; chemical elements; composite polymers; curcumin; drug carriers; encapsulation; free radicals; hydrophobicity; intravenous injection; nanoparticles; prostatic neoplasms; reactive oxygen species
Abstract:: ... Curcumin is a phytochemical with diverse molecular targets and is well known for its anti-tumor potential. However, it has limited application in cancer therapy because curcumin undergoes rapid oxidative degradation at physiological conditions resulting in poor stability and bio-availability. In this study, we were able to suppress curcumin's oxidative degradation by encapsulating it in a nanopart ...
DOI:: 10.1016/j.jconrel.2015.04.025
: https://doi.org/10.1016/j.jconrel.2015.04.025

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