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You searched for: Subject cytokines Remove constraint Subject: cytokines Subject term cerebrospinal fluid Remove constraint Subject term: cerebrospinal fluid Subject term animal injuries Remove constraint Subject term: animal injuries
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1. Application of Autologous Peripheral Blood Mononuclear Cells into the Area of Spinal Cord Injury in a Subacute Period: A Feasibility Study in Pigs

Author:
Iliya Shulman; Sergei Ogurcov; Alexander Kostennikov; Alexander Rogozin; Ekaterina Garanina; Galina Masgutova; Mikhail Sergeev; Albert Rizvanov; Yana Mukhamedshina
Source:
Biology 2021 v.10 no.2 pp. -
ISSN:
2079-7737
Subject:
animal injuries; blood serum; cerebrospinal fluid; cytokines; feasibility studies; fibrin; models; spinal cord; swine; therapeutics
Abstract:
... Peripheral blood presents an available source of cells for both fundamental research and clinical use. In our study, we have evaluated the therapeutic potential of peripheral blood mononuclear cells (PBMCs) excluding the preliminary sorting or mobilization of peripheral blood stem cells. We have evaluated the regenerative potential of PBMCs embedded into a fibrin matrix (FM) in a model of pig spin ...
DOI:
10.3390/biology10020087

2. CD8 T cell-derived perforin aggravates secondary spinal cord injury through destroying the blood-spinal cord barrier

Author:
Zhaoxiang Liu; Hua Zhang; Hong Xia; Baocheng Wang; Renwen Zhang; Qun Zeng; Lingzhi Guo; Kui Shen; BaTa Wang; Yanheng Zhong; Zhizhong Li; Guodong Sun
Source:
Biochemical and biophysical research communications 2019 v.512 no.2 pp. 367-372
ISSN:
0006-291X
Subject:
CD8-positive T-lymphocytes; animal injuries; animal models; biotin; cerebrospinal fluid; cytokines; enzyme-linked immunosorbent assay; flow cytometry; humans; infectious diseases; inflammation; mice; permeability; spinal cord; staining
Abstract:
... Perforin plays an important role in autoimmune and infectious diseases, but its function in immune inflammatory responses after spinal cord injury (SCI) has received insufficient attention. The goal of this study is to determine the influence of perforin after spinal cord injury (SCI) on secondary inflammation. Compared recovery from SCI in perforin knockout (Prf1−/−) and wild-type(WT)mice, WT mic ...
DOI:
10.1016/j.bbrc.2019.03.002