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You searched for: Subject demethylation Remove constraint Subject: demethylation Subject term DNA methylation Remove constraint Subject term: DNA methylation Subject term bisphenol A Remove constraint Subject term: bisphenol A
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1. Male exposure to bisphenol a impairs spermatogenesis and triggers histone hyperacetylation in zebrafish testes

Author:
S. González-Rojo; M. Lombó; C. Fernández-Díez; M.P. Herráez
Source:
Environmental pollution 2019 v.248 pp. 368-379
ISSN:
0269-7491
Subject:
DNA hypermethylation; Danio rerio; acetylation; adults; antagonists; apoptosis; bisphenol A; chromatin; demethylation; embryogenesis; endocrine-disrupting chemicals; enzyme activity; enzyme-linked immunosorbent assay; epigenetics; females; gene expression; gene expression regulation; hatching; histone acetyltransferase; histones; humans; immunocytochemistry; in vitro studies; males; meiosis; messenger RNA; progeny; quantitative polymerase chain reaction; receptors; reverse transcriptase polymerase chain reaction; spermatocytes; spermatogenesis; spermatozoa; surface water; testes; transcriptomics; water pollution
Abstract:
... Bisphenol A (BPA) is an endocrine disruptor whose ubiquitous presence in the environment has been related with impairment of male reproduction. BPA can cause both transcriptomic and epigenetic changes during spermatogenesis. To evaluate the potential effects of male exposure to BPA, adult zebrafish males were exposed during spermatogenesis to doses of 100 and 2000 μg/L, which were reported in cont ...
DOI:
10.1016/j.envpol.2019.01.127

2. Bisphenol A: What lies beneath its induced diabetes and the epigenetic modulation?

Author:
Soheila Rahmani; Nazila Pour Khalili; Fazlullah Khan; Shokoufeh Hassani; Elmira Ghafour-Boroujerdi; Mohammad Abdollahi
Source:
Life sciences 2018 v.214 pp. 136-144
ISSN:
0024-3205
Subject:
DNA methylation; adipocytes; animals; bisphenol A; demethylation; endocrine-disrupting chemicals; epigenetics; estrogenic properties; fatty liver; genes; glucose; histones; homeostasis; insulin; islets of Langerhans; lipids; liver; microRNA; noninsulin-dependent diabetes mellitus; obesity; pollution; skeletal muscle; toxicity
Abstract:
... Nowadays, endocrine disrupting chemical pollution has become one of the major concerns due to the potential role of these chemicals in provoking endocrine disorders especially type 2 diabetes. As a widespread endocrine disrupting chemical, Bisphenol A, with modest estrogenic activity can exert its detrimental effects in the different organs involved in type 2 diabetes such as pancreas, liver, adip ...
DOI:
10.1016/j.lfs.2018.10.044