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diabetes
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blood platelets
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- Author:
- Francesco Finamore; Jean-Luc Reny; Sarah Malacarne; Pierre Fontana; Jean-Charles Sanchez
- Source:
- Journal of proteomics 2019 v.192 pp. 258-266
- ISSN:
- 1874-3919
- Subject:
- acetylation; aspirin; blood platelets; cardiovascular diseases; diabetes; glucose; glycation; hyperglycemia; mass spectrometry; patients; prostaglandin synthase; proteins; risk factors; serine
- Abstract:
- ... Diabetes is a major risk factor for cardiovascular diseases. Although aspirin is considered a cornerstone of the prevention and treatment of atherothrombotic-related ischemic events, this antiplatelet drug appears to be less effective in patients with poorly controlled diabetes. It has been suggested that the glycation of platelet proteins plays a pivotal role in poor responsiveness to aspirin. Ho ...
- DOI:
- 10.1016/j.jprot.2018.09.007
- https://doi.org/10.1016/j.jprot.2018.09.007
- Author:
- Jung-Hae Shin; Muhammad Irfan; Man Hee Rhee; Hyuk-Woo Kwon
- Source:
- Applied biological chemistry 2021 v.64 no.1 pp. 4
- ISSN:
- 2468-0834
- Subject:
- Maclura tricuspidata; adhesion; assays; blood platelets; calcium; chemistry; cytotoxicity; diabetes; fibrinogen; fibronectins; flavonoids; humans; inflammation; measurement; neoplasms; obesity; platelet aggregation; research; sampling; thrombosis; xanthones; Asia
- Abstract:
- ... Cudrania tricuspidata (C. tricuspidata) is widespread throughout Asia and has known to have various physiological activities such as, inflammation, diabetes, obesity and tumor. Cudrania tricuspidata, a rich source of xanthones and flavonoids, have been investigated phytochemically and biologically. However, research of these compounds on platelets is limited. Therefore, we searched for a new subst ...
- DOI:
- 10.1186/s13765-020-00575-1
- https://doi.org/10.1186/s13765-020-00575-1
- Author:
- David Miaffo; Sylvie Léa Wansi; Fidèle Ntchapda; Albert Kamanyi
- Source:
- BMC complementary medicine and therapies 2020 v.20 no.1 pp. 106
- ISSN:
- 2662-7671
- Subject:
- Combretum; alanine transaminase; antioxidant activity; antioxidants; aspartate transaminase; blood platelets; blood sampling; blood serum; body weight; branches; catalase; creatinine; diabetes; electrolytes; enzyme activity; erythrocytes; glutathione; guidelines; hematocrit; hemoglobin; high density lipoprotein cholesterol; human health; laboratory animals; leukocytes; liver; low density lipoprotein cholesterol; malaria; malondialdehyde; mortality; poisoning; rats; renal clearance; shrubs; superoxide dismutase; therapeutics; toxicity; toxicity testing; traditional medicine; triacylglycerols; urinalysis; urine
- Abstract:
- ... BACKGROUND: Combretum molle R.B/G. Don (Combretaceae) is a graceful deciduous shrub, distributed especially in tropical Africa and used in traditional medicine in the treatment of malaria, diabetes, and bacterial, liver and cardiovascular deseases. To our knowledge, no long-term toxicity studies of C. molle has ever been realized yet. METHODS: The long-term toxicity study was conducted in accordan ...
- DOI:
- 10.1186/s12906-020-02896-6
- PubMed:
- 32248808
- PubMed Central:
- PMC7133017
- https://doi.org/10.1186/s12906-020-02896-6
- Author:
- Arraa M. Saghir Afifeh; Monica Verdoia; Matteo Nardin; Federica Negro; Filippo Viglione; Roberta Rolla; Giuseppe De Luca; Novara Atherosclerosis Study Group (NAS)
- Source:
- Nutrition, metabolism, and cardiovascular diseases 2021 v.31 no.1 pp. 36-43
- ISSN:
- 0939-4753
- Subject:
- C-reactive protein; age; angiography; biomarkers; blood platelets; calcitriol; cardiovascular diseases; chemiluminescence immunoassays; cholecalciferol; correlation; creatinine; diabetes; diuretics; exhibitions; fibrinogen; homocysteine; infection; metabolism; pandemic; patients; prediction; renal failure; risk; uric acid; variability; vitamin D deficiency
- Abstract:
- ... Vitamin D deficiency is a pandemic disorder affecting over 1 billion of subjects worldwide. Calcitriol (1,25(OH)2D) represents the perpetrator of the several systemic effects of vitamin D, including the anti-inflammatory, antithrombotic and anti-atherosclerotic actions, potentially preventing acute cardiovascular ischemic events. Variability in the transformation of vitamin D into 1,25(OH)2D has b ...
- DOI:
- 10.1016/j.numecd.2020.09.021
- https://doi.org/10.1016/j.numecd.2020.09.021
- Author:
- Boguslawa Luzak; Jacek Golanski; Tomasz Przygodzki; Magdalena Boncler; Dorota Sosnowska; Jan Oszmianski; Cezary Watala; Marcin Rozalski
- Source:
- Journal of functional foods 2016 v.22 pp. 257-269
- ISSN:
- 1756-4646
- Subject:
- Humulus lupulus; animal disease models; anticoagulant activity; blood platelets; coumaric acids; diabetes; endothelial cells; endothelium; flavanols; flavonols; glycosides; humans; placebos; platelet aggregation; proanthocyanidins; rats
- Abstract:
- ... Spent hop extract (SHE) is hypothesized to possess multifaceted anticoagulant effect and to reduce platelet reactivity in a direct manner and to improve the antiplatelet action of endothelium. The results demonstrated that SHE, rich in flavanols (50% of total phenolic compounds), hydroxycinnamic acids, proanthocyanidin oligomers, flavan-3-ol monomers, and flavonol glycosides, inhibited ADP-induced ...
- DOI:
- 10.1016/j.jff.2016.01.029
- https://doi.org/10.1016/j.jff.2016.01.029
- Author:
- Hui Min Tay; Wei Hseun Yeap; Rinkoo Dalan; Siew Cheng Wong; Han Wei Hou
- Source:
- Analytical chemistry 2018 v.90 no.24 pp. 14535-14542
- ISSN:
- 1520-6882
- Subject:
- atherosclerosis; biomarkers; blood platelets; cell viability; detection limit; diabetes; flow cytometry; fluorescent antibody technique; fractionation; image analysis; immune response; lymphocytes; macrophages; magnetism; microfluidic technology; monitoring; monocytes; patients; phagocytosis; point-of-care systems; risk assessment; thrombosis
- Abstract:
- ... Monocytes and platelets play key roles in atherosclerosis and thrombosis, and circulating monocyte–platelet aggregates (MPA) in blood have been widely proposed as surrogate biomarkers for cardiovascular risk stratification and monitoring antiplatelet therapies. However, conventional MPA characterization is based on whole-blood fixation and flow cytometry analysis which adversely affect cell viabil ...
- DOI:
- 10.1021/acs.analchem.8b04415
- https://doi.org/10.1021/acs.analchem.8b04415
- Author:
- Xinwei Jiang; Xusheng Li; Cuijuan Zhu; Jianxia Sun; Lingmin Tian; Wei Chen; Weibin Bai
- Source:
- Critical reviews in food science and nutrition 2019 v.59 no.6 pp. 921-946
- ISSN:
- 1549-7852
- Subject:
- adipocytes; anthocyanins; bioactive properties; blood platelets; chronic diseases; color; diabetes; endothelial cells; epidemiological studies; fatty liver; fruits; grains; hepatocytes; hypertension; intestinal microorganisms; intestines; islets of Langerhans; metabolic syndrome; metabolism; metabolites; myocytes; nutritional intervention; obesity; patients; skeletal muscle; structure-activity relationships; vegetables
- Abstract:
- ... Metabolic syndrome develops to several related chronic diseases, such as obesity, cardiovascular disease, hypertension, diabetes, and fatty liver disease. Diseases are outcomes of various cells dysfunction, which are especially acting with a network in metabolic syndrome. Anthocyanins are natural edible pigments widely existed in dark-colored fruits, vegetables, and grains. Epidemiological investi ...
- DOI:
- 10.1080/10408398.2018.1491022
- https://doi.org/10.1080/10408398.2018.1491022