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You searched for: Subject diabetes Remove constraint Subject: diabetes Subject term cardiovascular diseases Remove constraint Subject term: cardiovascular diseases Subject term blood platelets Remove constraint Subject term: blood platelets
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1. A high glucose level is associated with decreased aspirin-mediated acetylation of platelet cyclooxygenase (COX)-1 at serine 529: A pilot study

Author:
Francesco Finamore; Jean-Luc Reny; Sarah Malacarne; Pierre Fontana; Jean-Charles Sanchez
Source:
Journal of proteomics 2019 v.192 pp. 258-266
ISSN:
1874-3919
Subject:
acetylation; aspirin; blood platelets; cardiovascular diseases; diabetes; glucose; glycation; hyperglycemia; mass spectrometry; patients; prostaglandin synthase; proteins; risk factors; serine
Abstract:
... Diabetes is a major risk factor for cardiovascular diseases. Although aspirin is considered a cornerstone of the prevention and treatment of atherothrombotic-related ischemic events, this antiplatelet drug appears to be less effective in patients with poorly controlled diabetes. It has been suggested that the glycation of platelet proteins plays a pivotal role in poor responsiveness to aspirin. Ho ...
DOI:
10.1016/j.jprot.2018.09.007

2. Determinants of vitamin D activation in patients with acute coronary syndromes and its correlation with inflammatory markers

Author:
Arraa M. Saghir Afifeh; Monica Verdoia; Matteo Nardin; Federica Negro; Filippo Viglione; Roberta Rolla; Giuseppe De Luca; Novara Atherosclerosis Study Group (NAS)
Source:
Nutrition, metabolism, and cardiovascular diseases 2021 v.31 no.1 pp. 36-43
ISSN:
0939-4753
Subject:
C-reactive protein; age; angiography; biomarkers; blood platelets; calcitriol; cardiovascular diseases; chemiluminescence immunoassays; cholecalciferol; correlation; creatinine; diabetes; diuretics; exhibitions; fibrinogen; homocysteine; infection; metabolism; pandemic; patients; prediction; renal failure; risk; uric acid; variability; vitamin D deficiency
Abstract:
... Vitamin D deficiency is a pandemic disorder affecting over 1 billion of subjects worldwide. Calcitriol (1,25(OH)2D) represents the perpetrator of the several systemic effects of vitamin D, including the anti-inflammatory, antithrombotic and anti-atherosclerotic actions, potentially preventing acute cardiovascular ischemic events. Variability in the transformation of vitamin D into 1,25(OH)2D has b ...
DOI:
10.1016/j.numecd.2020.09.021