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... Urinary 1-hydroxypyrene (1-OH-pyrene) is now largely considered to be a valuable biomarker of exposure of man and animals to pyrene and other polycyclic aromatic hydrocarbons (PAHs). However, from a practical and agronomic standpoint, the question remains whether such biomarking capability still holds when 1-OH-pyrene is analyzed in milk produced by ruminants. To assess this hypothesis, four goats ...
Adhikari Snehunsu; Chitrini Ghosal; Mamta Kandwal; Pramod K. Yadav; B. Satheesha Nayak; K. Raghavendra Rao; Shobha U. Kamath; Pabitra Sahoo; K.K. Srinivasan; Sareesh Naduvil Narayanan; Shiva Kumar; Alex Joseph
... Marsilea quadrifolia Linn. (MQ) has been used for insomnia and epileptic disorders in traditional Indian medicine. The present study is to isolate the active component responsible for antiepileptic property of MQ by evaluating its ability to minimize the reactive oxidative damage in brain due to chronic epilepsy in rat.1-Triacontanol cerotate (1TAC) was isolated after chromatography on a silica ge ...
... Cortinarius caperatus grows in the northern regions of Europe, North America and Asia and is widely collected by mushroom foragers across Europe. This study shows that in the last three decades since the Chernobyl nuclear accident, C. caperatus collected across much of Northern Poland exhibited high activity concentrations of radiocaesium (137Cs) - a long-lived radionuclide. The mushroom appears t ...
DNA barcoding; Pimephales promelas; community structure; diet; dietary exposure; digestive system; ecotoxicology; environment; fish health; genomics; intestinal microorganisms; juveniles; microbiome; pollution; polycyclic aromatic hydrocarbons; species diversity
Abstract:
... Activities of gut microbiomes are often overlooked in assessments of ecotoxicological effects of environmental contaminants. Effects of the polycyclic aromatic hydrocarbon, benzo[a]pyrene (BaP) on active gut microbiomes of juvenile fathead minnows (Pimephales promelas) were investigated. Fish were exposed for two weeks, to concentrations of 0, 1, 10, 100, or 1000 μg BaP g⁻¹ in the diet. The active ...
... Using a 1H NMR metabolomics approach, the effects of dietary exposure of bunker A heavy oil (0.01, 0.1, 1, and 5% in diet) on freshwater carp, Cyprinus carpio, were examined. Statistical analysis by PCA score plots showed that the amount of metabolites in exposure groups 0.1, 1, and 5% differed from those in the control group. Although no discernible effects on metabolites were noted in the 0.1% e ...
... 2,6‐Di‐tert‐butyl‐hydroxytoluene (BHT, E‐321) is a synthetic phenolic antioxidant which has been widely used as an additive in the food, cosmetic, and plastic industries for the last 70 y. Although it is considered safe for human health at authorized levels, its ubiquitous presence and the controversial toxicological data reported are of great concern for consumers. In recent years, special attent ...
air pollution; alluvial plains; dietary exposure; ecosystems; fish; floodplains; inhalation exposure; mercury; monitoring; precautionary principle; public health; remediation; rivers; runoff; sediments; soil; streams; surface water; surveys; vegetables; water pollution; Italy
Abstract:
... This paper reports the results of a joint project carried out by three regional environmental agencies of Italy to evaluate long-range mercury (Hg) transport from the abandoned Mt. Amiata Hg district in southern Tuscany (the third largest worldwide site for Hg production) to the fluvial ecosystems of the Paglia and Tiber rivers. Most of the work focused on stream sediments, surface waters and soil ...
Robert L. Sprando; Miriam E. Mossoba; Thomas Black; Zachary Keltner; Sanah Vohra; Nicholas Olejnik; Howard Toomer; Cynthia Stine; Eric Evans; Jessica L. Sprando; Martine Ferguson
... The acute oral toxicity of diglycolic acid (DGA) was evaluated. Groups of female rats (n = 8 rats/group) received 28 consecutive daily single doses of 0.3, 1.0, 3.0, 10.0, 30.0, 100.0 or 300.0 mg DGA/kg body weight by gastric intubation. One group of animals served as vehicle control. Tissues and blood serum were collected at necropsy on day 29. Select organs were weighed and fixed in formalin for ...
... Washing of iceberg lettuce with HOCl solutions in concentrations ranging from 1.41 to 141mg/L resulted in 0.69 to 2.05μg3-chlorotyrosine/g vegetable. As also six commercial ready-to-eat iceberg lettuces from different producers contained 3-chlorotyrosine from 1.00 to 2.24μg/g vegetable, a total of 122 ready-to-eat vegetable samples purchased in Belgian supermarkets were further screened for their ...
... Docosahexaenoic acid (DHA) and arachidonic acid (ARA) are components of human breast milk and commonly added to infant formula. The first DHA-containing algal oil for infant formulas was DHASCO® produced from the microalgae Crypthecodinium cohnii. Recently, new DHA-rich oil was obtained from the microalgae Schizochytrium sp., herein named DHASCO-B. The objectives of this study were to evaluate the ...
... Octenyl succinic anhydride (OSA)-modified starch functions as both an emulsifier and emulsion stabilizer in foods, and is intended for use in infant formula, follow-on formula, and formulae for special medical purposes. These formulae predominantly include extensively hydrolyzed protein or free amino acids, rather than intact protein, which otherwise would provide emulsifying functionality. The st ...
... One of the most abundant oligosaccharides found in human milk is 2′-fucosyllactose, a trisaccharide composed of fucose and lactose, and multiple studies have demonstrated a health benefit to this compound. Recent advances have allowed for the large-scale production of oligosaccharides via fermentation, including 2′-fucosyllactose. A neonatal piglet model was used to evaluate the tolerability of 2′ ...
... Type 2 diabetes (T2D) is among the leading causes of mortality and morbidity globally. Patients living with T2D are best managed with anti-diabetic agents concurrently with a lifestyle adjustment. AMP-activated protein kinase (AMPK) has been implicated in multiple pathways associated with obesity and diabetes, which makes it a target for drug discovery. 56DHK is naturally found in the rhizomes of ...
... Although sublethal dosages of insecticide to nontarget insects have never been an important issue, they are attracting more and more attention lately. It has been demonstrated that low dosages of the neonicotinoid insecticide imidacloprid may affect honey bee, Apis mellifera L., behavior. In this article, the foraging behavior of the honey bee workers was investigated to show the effects of imidac ...
... Perfluoroalkyl substances (PFASs), such as perfluorooctanoic acid (PFOA), are environmentally persistent industrial chemicals often found in biosolids. Application of these biosolids to pastures raises concern about the accumulation of PFOA in the edible tissues of food animals. Because data on the absorption, distribution, metabolism, and excretion (ADME) of PFOA in cattle were unavailable, a stu ...
... The compound 2,4,6-trinitrotoluene (TNT) is a persistent contaminant of some industrial and military sites. Biological bioremediation techniques typically rely on the immobilization of TNT reduction products rather than on TNT mineralization. We hypothesized that sheep ruminal microbes would be suitable for TNT destruction after phytoremediation of TNT-contaminated soils by cool-season grasses. Th ...
absorption; adults; algorithms; antibiotics; bioavailability; children; chronic diseases; colon; daidzein; dietary exposure; excretion; genistein; health status; intestinal microorganisms; metabolism; neoplasms; postmenopause; premenopause; small intestine; urine; women
Abstract:
... Soy is the major source of dietary exposure to isoflavonoids (IFLs). Accumulating evidence supports a role for soy and IFLs in the protection against many chronic diseases including cancer. After soy intake we found a biphasic IFL appearance pattern in plasma as well as in urine that we suggest to be due to IFL absorption in the small intestine (ca. 10%) during the first 2h after intake and IFL ab ...
... Herein, we report the abundance and prevalence of HMO-metabolizing genes, specifically those of Bifidobacterium infantis, in fecal samples from human infants. Forty dyads were enrolled, and each mother collected a fecal sample from her infant at six months of age. Genomic DNA was extracted, and quantitative real-time PCR was used to determine gene abundance. The mode of delivery was not associated ...
Vespa velutina; World Health Organization; adults; dietary exposure; human health; ingredients; larvae; monitoring; nests; pollution; polychlorinated dibenzodioxins; polychlorinated dibenzofurans; risk; risk assessment; social wasps; toxicity; South Korea
Abstract:
... Detecting polychlorinated dibenzo-p-dioxins (PCDDs) and polychlorinated dibenzofurans (PCDFs) in an organism's environment is ecologically significant. In particular, the detection of PCDD/Fs in organisms consumed as food suggests the possibility of human health risks. In South Korea, there is a unique custom in which social wasps, such as hornets, have been used as ingredients in traditional liqu ...
... The acaricidal activity of methanolic extracts from the leaves of Havardia albicans (Kunth Britton and Rose) and Caesalpinia gaumeri (Greenm) were tested on the larvae and adults of the cattle tick Rhipicephalus microplus Canestrini using the larval immersion test and the adult immersion test, respectively. The toxicity of these extracts was also evaluated on laboratory animals using toxicity bioa ...
... In search for low-cost, safe and environmentally benign plant-based alternatives to commercial pesticides, the efficacy of Lippia javanica aqueous leaf extracts in controlling ticks on cattle, acute oral toxicity in mice and phytochemistry were evaluated. L. javanica aqueous leaf extracts at 10% and 20% w/v were effective at controlling cattle ticks but not as good as an amitraz-based acaricide Ti ...
dogs; fentanyl; overdose; veterinary drugs; transdermal application; drug toxicity; case studies; dietary exposure; ingestion
Abstract:
... A 100-μg hour⁻¹ transdermal fentanyl patch was applied to a 29-kg, 6-year-old, intact male mixed breed dog to help manage postoperative pain after total ear canal ablation and lateral bulla osteotomy. Two days later, the dog was found extremely sedated, and the reservoir of the transdermal patch was open. It was suspected that the dog ingested the contents of the reservoir of the transdermal patch ...
... A rotation experiment was conducted in a greenhouse with three vegetable crops on red yellowish soil (RYS) and silt loamy soil (SLS) to study Cd accumulation in pak choi (Brassica chinensis L.), tomato (Lycopersicon esculentum), and radish (Raphanus sativus L.). Critical Cd concentrations in the two soils were evaluated for these vegetables based on human dietary toxicity. Cadmium was added as Cd( ...
... Vanisulfane is a novel plant antiviral agent with promising prospects to prevent and control viral crop diseases. However, human health risk assessment after vanisulfane exposure from animal-derived food products remains limited. To gain insight into the accumulation and biotransformation of vanisulfane in livestock, laying hens were dietary exposed to ¹⁴C-vanisulfane. Although more than 80 % of t ...
... The aim of this study was to investigate metal accumulation and detoxification processes in cattle from polluted and unpolluted areas. Therefore dairy cows from farms and free ranging Galloway cows from nature reserves were used as study animals. The concentrations of Ag, Cd, Pb, Al, Cr, Mn, Fe, Co, Ni, Cu, Zn and As were determined in muscle, kidney, liver and lungs of cattle from polluted and re ...
... The brominated flame retardant hexabromocyclododecane (HBCD) has been reported in environmental samples worldwide. The three diastereomers, α-, β- and γ-HBCD, behave differently in aquatic food webs; likely depending on different factors influencing assimilation efficiency and metabolism. In the present study, two oral exposure experiments with rainbow trout were performed to assess the role of se ...
... Environmental contamination by energetic compounds is an increasing international concern, although little is known of their accumulation in and affect on wildlife. Reptiles are often good models for contaminants studies due to natural history traits that increase their potential for exposure. We report a study to assess accumulation and effects of octahydro-1,3,5,7-tetranitro-1,3,5,7-tetrazocine ...
water pollution; endosulfan; dietary exposure; Salmo salar; salmon; fish culture; bioaccumulation; fish fillets
Abstract:
... The carry-over of dietary endosulfan to the fillet of farmed Atlantic salmon was studied. The uptake and elimination rate constants of the α and β isoform of endosulfan were determined in seawater adapted Atlantic salmon (initial weigh 173±25g) fed on endosulfan enriched diets (724 and 315μgkg-¹ for α- and β-endosulfan, respectively) for 92 days, followed by a 56 days depuration period with feedin ...
water pollution; methylmercury compounds; mercury; dietary exposure; bioaccumulation; fish culture; Salmo salar; salmon; Gadus morhua; cod (fish); muscles
Abstract:
... Methylmercury is known to bioaccumulate and biomagnify up the marine food chain. Fish from high levels of the marine food chain may contain relatively high concentrations of mercury, and most (>70%) of the mercury found in muscle is methylmercury. In aquaculture, marine protein (mainly fishmeal) is the dominant source of methylmercury, and this raises some concern with regards to fish welfare and ...
... Dietary and waterborne exposure to copper oxide (CuO) and zinc oxide (ZnO) nanoparticles (NPs) was conducted using a simplified model of an aquatic food chain consisting of zooplankton (Artemia salina) and goldfish (Carassius auratus) to determine bioaccumulation, toxic effects, and particle transport through trophic levels. Artemia contaminated with NPs were used as food in dietary exposure. Fish ...
Monte Carlo method; acceptable daily intake; average daily intake; breast feeding; breast milk; dibenzofuran; dietary exposure; pollution; polychlorinated biphenyls; polychlorinated dibenzodioxins; probability distribution; risk; seafoods; toxicity; China
Abstract:
... Breast milk samples were collected from 51 mothers in a seaside city Dalian, where the residents usually have higher dietary exposure to polychlorinated dibenzo-p-dioxins and dibenzofurans (PCDD/Fs) and polychlorinated biphenyls (PCBs) due to the larger consumption of seafood. The lipid-basis concentrations of ∑Cl₂–₈DD/Fs, ∑Cl₂–₁₀Bs, and total toxicity equivalent (WHO-TEQ) were measured to be in t ...
... Polycyclic aromatic hydrocarbons (PAHs) are widespread pollutants in marine ecosystems including threatened and potentially sensitive coral reefs. Lower organisms such as phytoplankton, known to bioconcentrate PAHs, could serve as potential entry points for these chemicals into higher trophic levels. Here, we present a novel method using a ¹³C-labelled PAH and cavity ring-down spectroscopy (CRDS) ...
... Dietary methylmercury (MeHg) uptake by fish in relation to life stage, species, and level of exposure is poorly understood in lower trophic levels, particularly in estuarine species. The authors compared accumulation of dietary MeHg as well as sensitivity (survival and growth) to dietary MeHg exposure in two species of estuarine forage fish, Cyprinodon variegatus and Menidia beryllina. Fish were f ...
... Juvenile king scallops Pecten maximus of 1.23 cm shell height were exposed to domoic acid (DA) and the toxin accumulation and effects of bearing this toxin were investigated. After feeding on a formulated feed containing about 0.19 pg DA per particle for 7 days, the juvenile scallops incorporated a relatively low DA burden of 15.9 ng g⁻¹, which was similar to those exposed to 10 and 50 ng ml⁻¹ dis ...
... The exposure risk of metal-based nanoparticles (NPs) to marine organisms and related food safety have attracted increasing attention, but the actual concentrations of these NPs in seawater and marine organisms are unknown. In this work, single particle inductively coupled plasma-mass spectrometry (spICP-MS) was used to quantify the concentrations and size distributions of NPs in different marine m ...
... Bioaccumulation of sediment‐associated polychlorinated biphenyls (PCBs) was examined in Atlantic cod (Gadus morhua) through direct diffusion from the sediment (via the water phase) and through the food chain (dietary exposure). To facilitate direct accumulation from the sediment, it was continuously resuspended. To study the dietary bioaccumulation of PCBs, cod were fed benthic polychaetes (Nereis ...
average daily intake; dietary exposure; fish; fish consumption; freshwater; ingestion; neoplasms; nutrition assessment; polychlorinated biphenyls; risk; socioeconomics; toxicity; India
Abstract:
... The objective of this study is to determine the concentrations of polychlorinated biphenyls (PCBs) in different fish species collected from fish outlets in the south Indian city of Hyderabad. The samples of fish extracted by using Quick, Easy, Cheap, Effective, Rugged, and Safe (QuEChERS) and concentrations of polychlorinated biphenyls (PCBs, 45 congeners) were determined by gas chromatography–mic ...
... Microplastics have become a worldwide pollutant, widely discovered in soil, air and aquatic environment. Microplastics have been found in habitats where crayfish (Procambarus clarkii) cultivated, but the impact of microplastics on crayfish remains unclear. In this study, after 21-day dietary exposure, polyethylene (PE) particles were found to accumulate in intestine, hepatopancreas, gills and hemo ...
... Reliable human health risk assessment associated with chlorinated paraffins (CPs) exposure is limited by the lack of data on the fate of this complex family of contaminants. To gain knowledge on the accumulation and distribution of CPs in biota after ingestion, laying hens were dietary exposed to technical mixtures of short- (SCCPs), medium- (MCCPs), or long-chain (LCCPs) CPs of various chlorine c ...
Micropogonias undulatus; climate change; diet; dietary exposure; estuarine fish; pellets; predators; reflexes; swimming; thyroid hormones; water temperature
Abstract:
... Rising water temperatures due to climate change may increase the uptake and effects of triclosan in aquatic organisms. Our objectives were to investigate the accumulation of dietary triclosan and its neuroendocrine effects in Atlantic croaker, an estuarine fish, under two temperatures and during depuration. A pilot study was used to select a dietary exposure of 50 mg/kg. For 10 days, fish were exp ...
additive effect; adults; anthropogenic activities; arsenic; average daily intake; cadmium; cattle; chickens; children; chromium; cobalt; copper; dietary exposure; environmental health; food intake; foods; gizzard; goats; heavy metals; human health; international policy and programs; iron; kidneys; lead; liver; manganese; mercury; muscles; nickel; pollutants; principal component analysis; risk; risk estimate; spectrometers; terrestrial ecosystems; tissues; urban population; zinc; Nigeria
Abstract:
... The use of free range animals for monitoring environmental health offers opportunities to detect exposure and assess the toxicological effects of pollutants in terrestrial ecosystems. Potential human health risk of dietary intake of metals and metalloid via consumption of offal and muscle of free range chicken, cattle and goats by the urban population in Benin City was evaluated. Muscle, gizzard, ...