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- Danilo Basili; Ji-Liang Zhang; John Herbert; Kevin Kroll; Nancy D. Denslow; Christopher J. Martyniuk; Francesco Falciani; Philipp Antczak
- Environmental science & technology 2018 v.52 no.13 pp. 7553-7565
- Micropterus salmoides; animal ovaries; databases; dynamic models; endocrine-disrupting chemicals; environmental science; estradiol; females; fish communities; gene expression; gene expression regulation; genes; gonadosomatic index; liver; males; ovarian development; prediction; quantitative polymerase chain reaction; quercetin; transcription (genetics); transcriptomics; vitellogenin
- ... In recent years, decreases in fish populations have been attributed, in part, to the effect of environmental chemicals on ovarian development. To understand the underlying molecular events we developed a dynamic model of ovary development linking gene transcription to key physiological end points, such as gonadosomatic index (GSI), plasma levels of estradiol (E2) and vitellogenin (VTG), in largemo ...
- Raju Prasad Sharma; Marta Schuhmacher; Vikas Kumar
- Environment international 2016 pp. -
- action potentials; case studies; developmental stages; dynamic models; endocrine-disrupting chemicals; female fertility; germ cells; homeostasis; mechanism of action; metabolism; risk; risk assessment; toxicity
- ... Endocrine disruptor compounds (EDCs) are environment chemicals that cause harmful effects through multiple mechanisms, interfering with hormone system resulting in alteration of homeostasis, reproduction and developmental effect. Many of these EDCs have concurrent exposure with crosstalk and common mechanisms which may lead to dynamic interactions. To carry out risk assessment of EDCs' mixture, it ...