U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Subject endocrine-disrupting chemicals Remove constraint Subject: endocrine-disrupting chemicals Subject term endocrine-disrupting chemicals Remove constraint Subject term: endocrine-disrupting chemicals Subject term dynamic models Remove constraint Subject term: dynamic models Text availability Citation in PubAg Remove constraint Text availability: Citation in PubAg
Start Over

Search

2  Search Results

1 - 2 of 2
Number of results to display per page

Search Results

1. In Silico Computational Transcriptomics Reveals Novel Endocrine Disruptors in Largemouth Bass (Micropterus salmoides)

Author:
Danilo Basili; Ji-Liang Zhang; John Herbert; Kevin Kroll; Nancy D. Denslow; Christopher J. Martyniuk; Francesco Falciani; Philipp Antczak
Source:
Environmental science & technology 2018 v.52 no.13 pp. 7553-7565
ISSN:
1520-5851
Subject:
Micropterus salmoides; animal ovaries; databases; dynamic models; endocrine-disrupting chemicals; environmental science; estradiol; females; fish communities; gene expression; gene expression regulation; genes; gonadosomatic index; liver; males; ovarian development; prediction; quantitative polymerase chain reaction; quercetin; transcription (genetics); transcriptomics; vitellogenin
Abstract:
... In recent years, decreases in fish populations have been attributed, in part, to the effect of environmental chemicals on ovarian development. To understand the underlying molecular events we developed a dynamic model of ovary development linking gene transcription to key physiological end points, such as gonadosomatic index (GSI), plasma levels of estradiol (E2) and vitellogenin (VTG), in largemo ...
DOI:
10.1021/acs.est.8b02805

2. Review on crosstalk and common mechanisms of endocrine disruptors: Scaffolding to improve PBPK/PD model of EDC mixture

Author:
Raju Prasad Sharma; Marta Schuhmacher; Vikas Kumar
Source:
Environment international 2016 pp. -
ISSN:
0160-4120
Subject:
action potentials; case studies; developmental stages; dynamic models; endocrine-disrupting chemicals; female fertility; germ cells; homeostasis; mechanism of action; metabolism; risk; risk assessment; toxicity
Abstract:
... Endocrine disruptor compounds (EDCs) are environment chemicals that cause harmful effects through multiple mechanisms, interfering with hormone system resulting in alteration of homeostasis, reproduction and developmental effect. Many of these EDCs have concurrent exposure with crosstalk and common mechanisms which may lead to dynamic interactions. To carry out risk assessment of EDCs' mixture, it ...
DOI:
10.1016/j.envint.2016.09.016