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1. Adipose Tissue Macrophage-Derived Exosomal miRNAs Can Modulate In Vivo and In Vitro Insulin Sensitivity

Author:
Wei Ying; Matthew Riopel; Gautam Bandyopadhyay; Yi Dong; Amanda Birmingham; Jong Bae Seo; Jachelle M. Ofrecio; Joshua Wollam; Angelina Hernandez-Carretero; Wenxian Fu; Pingping Li; Jerrold M. Olefsky
Source:
Cell 2017 v.171 pp. 372-384.e12
ISSN:
0092-8674
Subject:
adipose tissue; animal disease models; bone marrow; exosomes; glucose; glucose tolerance; homeostasis; insulin; insulin resistance; macrophages; mice; microRNA; obesity; phenotype
Abstract:
... MiRNAs are regulatory molecules that can be packaged into exosomes and secreted from cells. Here, we show that adipose tissue macrophages (ATMs) in obese mice secrete miRNA-containing exosomes (Exos), which cause glucose intolerance and insulin resistance when administered to lean mice. Conversely, ATM Exos obtained from lean mice improve glucose tolerance and insulin sensitivity when administered ...
DOI:
10.1016/j.cell.2017.08.035

2. Adipose mesenchymal stem cell-derived exosomes ameliorate hypoxia/serum deprivation-induced osteocyte apoptosis and osteocyte-mediated osteoclastogenesis in vitro

Author:
Lin Ren; Zi-jun Song; Qing-wei Cai; Rui-xin Chen; Yang Zou; Qiang Fu; Yuan-yuan Ma
Source:
Biochemical and biophysical research communications 2019 v.508 no.1 pp. 138-144
ISSN:
0006-291X
Subject:
acid phosphatase; age; apoptosis; blood serum; bone marrow; bone resorption; caspase-3; caspase-9; cell lines; cytochrome c; exosomes; genes; hypoxia; mesenchymal stromal cells; messenger RNA; models; monocytes; osteoclasts; protein content; staining; therapeutics
Abstract:
... Age-related skeletal changes is closely associated with imbalanced bone remodeling characterized by elevated osteocyte apoptosis and osteoclast activation. Since osteocytes are the commander of bone remodeling, attenuating increased osteocyte apoptosis may improve age-related bone loss. Exosomes, derived from mesenchymal stem cells, hold promising potential for cell-free therapy due to multiple ab ...
DOI:
10.1016/j.bbrc.2018.11.109

3. Adult mesenchymal stem cells and their exosomes: Sources, characteristics, and application in regenerative medicine

Author:
Maria Maqsood; Mingzhu Kang; Xiaotao Wu; Jinghua Chen; Liping Teng; Lipeng Qiu
Source:
Life sciences 2020 v.256 pp. 118002
ISSN:
0024-3205
Subject:
adults; biocompatible materials; bone marrow; exosomes; genomics; humans; medicine; therapeutics; umbilical cord
Abstract:
... Human mesenchymal stem cells (MSCs) have become a hot topic in the development of cell therapies and bioengineering. All kinds of MSCs are genomic stable and have the self-renewal ability. Main sources of MSCs are bone marrow, adipose tissues, umbilical cord and placental tissues. MSCs can be cultured in many undifferentiated passages to grow into more specialized cells, produce secretory factors ...
DOI:
10.1016/j.lfs.2020.118002

4. Analysis of Peripheral Blood Mononuclear Cells Gene Expression Highlights the Role of Extracellular Vesicles in the Immune Response following Hematopoietic Stem Cell Transplantation in Children

Author:
Wojciech Strojny; Kinga Kwiecińska; Przemysław Hałubiec; Wojciech Kowalczyk; Karol Miklusiak; Agnieszka Łazarczyk; Szymon Skoczeń
Source:
Genes 2021 v.12 no.12 pp. -
ISSN:
2073-4425
Subject:
B-lymphocytes; bioinformatics; bone marrow; cell transplantation; epigenetics; exosomes; gene expression; gene expression regulation; gene ontology; genes; hematopoietic stem cells; immune response; microarray technology; prospective studies; protein-protein interactions; risk
Abstract:
... Hematopoietic stem cell transplantation (HSCT) is an effective treatment method used in many neoplastic and non-neoplastic diseases that affect the bone marrow, blood cells, and immune system. The procedure is associated with a risk of adverse events, mostly related to the immune response after transplantation. The aim of our research was to identify genes, processes and cellular entities involved ...
DOI:
10.3390/genes12122008

5. The BMSC-derived exosomal lncRNA Mir9-3hg suppresses cardiomyocyte ferroptosis in ischemia-reperfusion mice via the Pum2/PRDX6 axis

Author:
Jian-Kai Zhang; Zhi Zhang; Zi-Ao Guo; Yuan Fu; Xiao-Jia Chen; Wei-Jie Chen; Hong-Fu Wu; Xiao-Jun Cui
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 v.32 no.2 pp. 515-527
ISSN:
0939-4753
Subject:
bone marrow; cardiac output; cardiomyocytes; cell proliferation; chromatin immunoprecipitation; exosomes; ferroptosis; genes; glutathione; hypoxia; metabolism; mice; nutrition; peroxiredoxin; reactive oxygen species
Abstract:
... The exosomal long noncoding RNAs (lncRNAs) have been reported to have cardioprotective effects on ischemia-reperfusion (I/R) injury by hindering ferroptosis, but the role of lncRNA Mir9-3 host gene (Mir9-3hg) in cardiac I/R injury remains unclear.Exosomes were extracted from mouse bone marrow mesenchymal stem cells (BMSCs) and identified by detecting the exosome specific marker levels, and the res ...
DOI:
10.1016/j.numecd.2021.10.017

6. BMSC-derived exosomes alleviate smoke inhalation lung injury through blockade of the HMGB1/NF-κB pathway

Author:
Bin Xu; Chun-xia Gan; Si-si Chen; Jia-qi Li; Ming-zhuo Liu; Guang-hua Guo
Source:
Life sciences 2020 v.257 pp. 118042
ISSN:
0024-3205
Subject:
Western blotting; bone marrow; breathing; exosomes; lungs; mesenchymal stromal cells; nucleoproteins; smoke; therapeutics; transmission electron microscopy
Abstract:
... To investigate the role of bone marrow mesenchymal stem cell (BMSC)-derived exosomes in smoke inhalation lung injury. In this study, we initially isolated exosomes from BMSCs and identified them by western blot and transmission electron microscopy. BMSC-derived exosomes were then used to treat in vitro and in vivo models of smoke inhalation lung injury. Pathologic alterations in lung tissue, the l ...
DOI:
10.1016/j.lfs.2020.118042

7. BMSCs overexpressed ISL1 reduces the apoptosis of islet cells through ANLN carrying exosome, INHBA, and caffeine

Author:
Ying Wang; Jiang-Wei Zhang; Jing-Wen Wang; Jia-Le Wang; Shu-Cong Zhang; Rui-Yang Ma; Jing Zhang; Yang Li; Pei-Jun Liu; Wu-Jun Xue; Jin Zheng; Xiao-Ming Ding
Source:
Cellular and molecular life sciences 2022 v.79 no.10 pp. 538
ISSN:
1420-682X
Subject:
angiogenesis; aniline; apoptosis; bone marrow; caffeine; exosomes; genes; inhibin; insulin; metabolomics; proteomics; streptozotocin; survival rate; transcription factors
Abstract:
... Early apoptosis of grafted islets is one of the main factors affecting the efficacy of islet transplantation. The combined transplantation of islet cells and bone marrow mesenchymal stem cells (BMSCs) can significantly improve the survival rate of grafted islets. Transcription factor insulin gene enhancer binding protein 1 (ISL1) is shown to promote the angiogenesis of grafted islets and the parac ...
DOI:
10.1007/s00018-022-04571-0

8. BMSCs-derived miR-223-containing exosomes contribute to liver protection in experimental autoimmune hepatitis

Author:
Lu Chen; Feng-bin Lu; Da-zhi Chen; Jin-lu Wu; En-de Hu; Lan-man Xu; Ming-hua Zheng; Hui Li; Yu Huang; Xiao-ya Jin; Yue-wen Gong; Zhuo Lin; Xiao-dong Wang; Yong-ping Chen
Source:
Molecular Immunology 2018 v.93 pp. 38-46
ISSN:
0161-5890
Subject:
adenosine triphosphate; alanine transaminase; antigens; aspartate transaminase; autoimmune diseases; autoimmune hepatitis; beta-galactosidase; blood serum; bone marrow; caspase-1; cell death; cytokines; exosomes; hepatocytes; histology; inflammation; liver; liver cirrhosis; messenger RNA; mice; models; stem cells; ultracentrifugation
Abstract:
... Autoimmune hepatitis is a chronic inflammatory disease in the liver with potential to the development of liver fibrosis. Recent evidences suggest that bone marrow derived mesenchymal stem cells (BMSCs) may exert its therapeutic activity through exosomes. Moreover, miR-223 is highly expressed in BMSCs and plays an important role in autoimmune diseases. Therefore, in this study, hepatoprotective rol ...
DOI:
10.1016/j.molimm.2017.11.008

9. Bone marrow mesenchymal stem cell-derived exosomes alleviate hyperoxia-induced lung injury via the manipulation of microRNA-425

Author:
Yunfei Wu; Jun Li; Rui Yuan; Zihui Deng; Xu Wu
Source:
Archives of biochemistry and biophysics 2021 v.697 pp. 108712
ISSN:
0003-9861
Subject:
apoptosis; biophysics; bone marrow; cell viability; exosomes; hyperoxia; luciferase; lungs; microRNA; protective effect; rats
Abstract:
... Hyperoxia-induced lung injury (HILI) is an acute lung injury (LI) induced by extended periods of exposure to hyperoxia. Alleviating LI by bone marrow mesenchymal stem cell-derived exosomes (BMSCs-Exos) and microRNAs (miRs) has been previously reported. This study is devised to probe the interaction between BMSCs-Exos and miR-425 in HILI.Firstly, BMSCs-Exos were isolated and identified. Then, HILI ...
DOI:
10.1016/j.abb.2020.108712

10. Bone marrow mesenchymal stem cell-derived exosomes attenuate cardiac hypertrophy and fibrosis in pressure overload induced remodeling

Author:
Fu Chen; Xueling Li; Jinxuan Zhao; Jin Geng; Jun Xie; Biao Xu
Source:
In vitro cellular & developmental biology 2020 v.56 no.7 pp. 567-576
ISSN:
1071-2690
Subject:
apoptosis; bone marrow; cardiac output; cardiomyocytes; centrifugation; echocardiography; exosomes; fibrosis; fluorescence; heart failure; histology; hypertrophy; mice; reverse transcriptase polymerase chain reaction; therapeutics
Abstract:
... The multiple therapeutic effects of bone marrow mesenchymal stem cells (BM-MSCs) have been verified in ischemic and reperfusion diseases. Exosomes are thought to play vital roles in MSCs-related cardioprotective effects. Recently, more and more evidences indicated that apoptosis and fibrosis were crucial pathological mechanisms in cardiac remodeling. Whether MSCs-derived exosomes could regulate ca ...
DOI:
10.1007/s11626-020-00481-2

11. Bone marrow mesenchymal stem cell-derived exosomes enhance osteoclastogenesis during alveolar bone deterioration in rats

Author:
Shuyu Xu; Zuolin Wang
Source:
RSC advances 2017 v.7 no.34 pp. 21153-21163
ISSN:
2046-2069
Subject:
animal models; bone marrow; bone resorption; cell lines; coculture; dentures; elderly; exosomes; females; mesenchymal stromal cells; osteoclasts; osteoporosis; ovariectomy; pathogenesis; patients; rats; synergism
Abstract:
... Healthy and functional alveolar bones to support implants or dentures are fundamental for dental restoration. Osteoporosis, which leads to alveolar bone resorption, is a common disease, especially in elderly patients with tooth loss. Enhanced osteoclastogenesis is the main pathogenesis of bone resorption, which is related to the paracrine regulation of BMMSCs (bone marrow mesenchymal stem cells). ...
DOI:
10.1039/c6ra27931g

12. Bone marrow mesenchymal stem cells-derived exosomal microRNA-16-5p restrains epithelial-mesenchymal transition in breast cancer cells via EPHA1/NF-κB signaling axis

Author:
Yuan Zhang; Xiaofeng Lai; Qingfang Yue; Fei Cao; Yue Zhang; Yang Sun; Jun Tian; Yizhao Lu; Li He; Jun Bai; Yifang Wei
Source:
Genomics 2022 v.114 no.3 pp. 110341
ISSN:
0888-7543
Subject:
bone marrow; breast neoplasms; carcinogenesis; exosomes; gene overexpression; genomics; mice; xenotransplantation
Abstract:
... This study intends to conquer the mystery of microRNA-16-5p/erythropoietin-producing hepatocellular A1/nuclear factor-κB signaling (miR-16-5p/EPHA1/NF-κB signaling) in breast cancer. Expression of miR-16-5p, EPHA1 and NF-κB signaling-related proteins were detected. Gene overexpression or silencing was used to examine the biological roles of bone marrow mesenchymal stem cells (BMSCs)-derived exo-mi ...
DOI:
10.1016/j.ygeno.2022.110341

13. Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-1-5p reduces proliferation and raises apoptosis of bladder cancer cells via targeting ABL2

Author:
Dewang Fu; Ben Liu; Huamao Jiang; Zhaowei Li; Chenghui Fan; Li'e Zang
Source:
Genomics 2021 v.113 no.3 pp. 1338-1348
ISSN:
0888-7543
Subject:
apoptosis; bone marrow; cell communication; coculture; exosomes; genomics; microRNA; tyrosine; urinary bladder neoplasms
Abstract:
... Exosomes are involved in intercellular communication via specialized molecular cargo, such as microRNAs (miRNAs). However, the mechanisms underlying exosomal miR-19b-1-5p in bladder cancer remain largely unknown, thus, we aim to investigate the effect of exosomal miR-19b-1-5p on bladder cancer with the involvement of non-receptor protein tyrosine kinase Arg (ABL2). miR-19b-1-5p and ABL2 expression ...
DOI:
10.1016/j.ygeno.2021.03.011

14. Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-3p targets SOCS1 to facilitate progression of esophageal cancer

Author:
Yanchao Deng; Ainiwaer Julaiti; Wei Ran; Yao He
Source:
Life sciences 2021 v.278 pp. 119491
ISSN:
0024-3205
Subject:
apoptosis; bone marrow; cytokines; esophageal neoplasms; exosomes; luciferase; microRNA; reporter genes
Abstract:
... Exosomes can convey particular microRNAs (miRNAs) to affect biological functions of cancer cells. Nevertheless, the impact of bone marrow mesenchymal stem cells (BMSCs)-derived exosomes (BMSC-exos) transmitting miR-19b-3p on esophageal cancer (EC) progression remains scarcely studied. We aimed to explore the role of BMSC-exos mediating miR-19b-3p in EC cell growth. Eighty-three cases of EC patient ...
DOI:
10.1016/j.lfs.2021.119491

15. Bone marrow mesenchymal stem cell–derived exosomes alleviate high phosphorus-induced vascular smooth muscle cells calcification by modifying microRNA profiles

Author:
Yan Guo; Shumin Bao; Wang Guo; Zongli Diao; Liyan Wang; Xue Han; Weikang Guo; Wenhu Liu
Source:
Functional & integrative genomics 2019 v.19 no.4 pp. 633-643
ISSN:
1438-793X
Subject:
alkaline phosphatase; bone marrow; calcification; calcium; cardiovascular diseases; exosomes; gene expression; gene expression regulation; genes; humans; kidney diseases; mesenchymal stromal cells; microRNA; mitogen-activated protein kinase; mortality; myocytes; patients; phosphorus; signal transduction; smooth muscle; therapeutics
Abstract:
... Vascular calcification is a common complication in patients with chronic kidney disease (CKD). It is an important predictor of cardiovascular disease and all-cause mortality. Previous studies have confirmed that bone marrow mesenchymal stem cell (BMSC) therapy can reduce vascular calcification, but the specific mechanism is still controversial. In this study, we aimed to investigate the mechanisms ...
DOI:
10.1007/s10142-019-00669-0

16. Canine colostrum exosomes: characterization and influence on the canine mesenchymal stem cell secretory profile and fibroblast anti-oxidative capacity

Author:
Antonio J. Villatoro; María del Carmen Martín-Astorga; Cristina Alcoholado; José Becerra
Source:
BMC veterinary research 2020 v.16 no.1 pp. 417
ISSN:
1746-6148
Subject:
Western blotting; adipose tissue; angiogenesis; antioxidant activity; bone marrow; chemotaxis; colostrum; dogs; exosomes; fibroblasts; hematopoiesis; immunity; immunoglobulins; mammary glands; mesenchymal stromal cells; milk; neonates; neurogenesis; proteomics; reactive oxygen species; secretion; veterinary medicine
Abstract:
... BACKGROUND: Canine colostrum milk (CCM) is a specific secretion of the mammary gland that is fundamental for the survival of the newborn. CCM has many described components (immunoglobulins, proteins or fat), but its small vesicles, named exosomes, are largely unknown. RESULTS: A characterization of CCM exosomes was performed. Exosomes were abundant in CCM and appeared with the characteristic cup-s ...
DOI:
10.1186/s12917-020-02623-w

17. Comparative analysis and characterization of soluble factors and exosomes from cultured adipose tissue and bone marrow mesenchymal stem cells in canine species

Author:
A.J. Villatoro; C. Alcoholado; M.C. Martín-Astorga; V. Fernández; M. Cifuentes; J. Becerra
Source:
Veterinary immunology and immunopathology 2019 v.208 pp. 6-15
ISSN:
0165-2427
Subject:
adipose tissue; bioactive compounds; bone marrow; dogs; exosomes; immunomodulators; interferon-gamma; interleukin-10; interleukin-12; interleukin-2; interleukin-6; interleukin-8; mechanism of action; mesenchymal stromal cells; mitogens; nitric oxide; proteins; proteomics; secretion; therapeutics; tissue repair; transforming growth factor beta; vascular endothelial growth factor A
Abstract:
... The two main sources of mesenchymal stem cell (MSCs) in the canine species are bone marrow (cBM-MSCs) and adipose tissue (cAd-MSCs). The secretion of multitude bioactive molecules, included under the concept of secretome and found in the cultured medium, play a predominant role in the mechanism of action of these cells on tissue regeneration. Although certain features of its characterization are w ...
DOI:
10.1016/j.vetimm.2018.12.003

18. Contribution of extracellular vesicles in normal hematopoiesis and hematological malignancies

Author:
Soudeh Ghafouri-Fard; Vahid Niazi; Mohammad Taheri
Source:
Heliyon 2021 v.7 no.1 pp. e06030
ISSN:
2405-8440
Subject:
bone marrow; endosomes; exosomes; hematopoiesis; leukemia; lipids; medicine; megakaryocytes; myeloma; pathogenesis; plasma membrane; therapeutics
Abstract:
... Extracellular vesicles (EVs) are lipid bilayer-enclosed microparticles that have prominent roles in the intercellular crosstalk. EVs are secreted after fusion of endosomes with the plasma membrane (exosomes) or shed from the plasma membrane (microvesicles). These microparticles modulate bone marrow microenvironment and alter differentiation and expansion of normal hematopoietic cells. EVs originat ...
DOI:
10.1016/j.heliyon.2021.e06030

19. Cryptic erythrocytic infections in Plasmodium vivax, another challenge to its elimination

Author:
Carmen Fernandez-Becerra; Iris Aparici-Herraiz; Hernando A. del Portillo
Source:
Parasitology international 2022 v.87 pp. 102527
ISSN:
1383-5769
Subject:
Plasmodium vivax; antimalarials; bone marrow; exosomes; geographical distribution; humans; immune response; liver; malaria; parasitology; people; risk; spleen; Asia
Abstract:
... Human malaria caused by Plasmodium vivax infection (vivax malaria) is a major global health issue. It is the most geographically widespread form of the disease, accounting for 7 million annual clinical cases, the majority of cases in America and Asia and an estimation of over 2.5 billion people living under risk of infection. The general perception towards vivax malaria has shifted recently, follo ...
DOI:
10.1016/j.parint.2021.102527

20. Do tumor exosome integrins alone determine organotropic metastasis?

Author:
E. S. Grigoryeva; O. E. Savelieva; N. O. Popova; N. V. Cherdyntseva; V. M. Perelmuter
Source:
Molecular biology reports 2020 v.47 no.10 pp. 8145-8157
ISSN:
0301-4851
Subject:
T-lymphocytes; adhesion; algorithms; bone marrow; endothelium; exosomes; inflammation; integrins; ligands; metastasis; molecular biology; neoplasms; therapeutics
Abstract:
... Metastasis is the most life-threatening event in cancer patients, so the key strategy to treat cancer should be preventing tumor spread. Predicting the site of probable hematogenous metastasis is important for determining the therapeutic algorithm that could prevent the spread of tumor cells. Certain hopes for solving this problem appeared owing to study showing the association between specific in ...
DOI:
10.1007/s11033-020-05826-4