U.S. flag

An official website of the United States government

Dot gov

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Https

Secure .gov websites use HTTPS
A lock ( ) or https:// means you’ve safely connected to the .gov website. Share sensitive information only on official, secure websites.

PubAg

Main content area

You searched for: Subject exosomes Remove constraint Subject: exosomes Subject bone marrow Remove constraint Subject: bone marrow
Start Over

Search

62  Search Results

« Previous | 1 - 20 of 62 |
Number of results to display per page

Search Results

1. The BMSC-derived exosomal lncRNA Mir9-3hg suppresses cardiomyocyte ferroptosis in ischemia-reperfusion mice via the Pum2/PRDX6 axis

Author:
Jian-Kai Zhang; Zhi Zhang; Zi-Ao Guo; Yuan Fu; Xiao-Jia Chen; Wei-Jie Chen; Hong-Fu Wu; Xiao-Jun Cui
Source:
Nutrition, metabolism, and cardiovascular diseases 2022 v.32 no.2 pp. 515-527
ISSN:
0939-4753
Subject:
bone marrow; cardiac output; cardiomyocytes; cell proliferation; chromatin immunoprecipitation; exosomes; ferroptosis; genes; glutathione; hypoxia; metabolism; mice; nutrition; peroxiredoxin; reactive oxygen species
Abstract:
... The exosomal long noncoding RNAs (lncRNAs) have been reported to have cardioprotective effects on ischemia-reperfusion (I/R) injury by hindering ferroptosis, but the role of lncRNA Mir9-3 host gene (Mir9-3hg) in cardiac I/R injury remains unclear.Exosomes were extracted from mouse bone marrow mesenchymal stem cells (BMSCs) and identified by detecting the exosome specific marker levels, and the res ...
DOI:
10.1016/j.numecd.2021.10.017

2. BMSCs overexpressed ISL1 reduces the apoptosis of islet cells through ANLN carrying exosome, INHBA, and caffeine

Author:
Ying Wang; Jiang-Wei Zhang; Jing-Wen Wang; Jia-Le Wang; Shu-Cong Zhang; Rui-Yang Ma; Jing Zhang; Yang Li; Pei-Jun Liu; Wu-Jun Xue; Jin Zheng; Xiao-Ming Ding
Source:
Cellular and molecular life sciences 2022 v.79 no.10 pp. 538
ISSN:
1420-682X
Subject:
angiogenesis; aniline; apoptosis; bone marrow; caffeine; exosomes; genes; inhibin; insulin; metabolomics; proteomics; streptozotocin; survival rate; transcription factors
Abstract:
... Early apoptosis of grafted islets is one of the main factors affecting the efficacy of islet transplantation. The combined transplantation of islet cells and bone marrow mesenchymal stem cells (BMSCs) can significantly improve the survival rate of grafted islets. Transcription factor insulin gene enhancer binding protein 1 (ISL1) is shown to promote the angiogenesis of grafted islets and the parac ...
DOI:
10.1007/s00018-022-04571-0

3. Bone marrow mesenchymal stem cells-derived exosomal microRNA-16-5p restrains epithelial-mesenchymal transition in breast cancer cells via EPHA1/NF-κB signaling axis

Author:
Yuan Zhang; Xiaofeng Lai; Qingfang Yue; Fei Cao; Yue Zhang; Yang Sun; Jun Tian; Yizhao Lu; Li He; Jun Bai; Yifang Wei
Source:
Genomics 2022 v.114 no.3 pp. 110341
ISSN:
0888-7543
Subject:
bone marrow; breast neoplasms; carcinogenesis; exosomes; gene overexpression; genomics; mice; xenotransplantation
Abstract:
... This study intends to conquer the mystery of microRNA-16-5p/erythropoietin-producing hepatocellular A1/nuclear factor-κB signaling (miR-16-5p/EPHA1/NF-κB signaling) in breast cancer. Expression of miR-16-5p, EPHA1 and NF-κB signaling-related proteins were detected. Gene overexpression or silencing was used to examine the biological roles of bone marrow mesenchymal stem cells (BMSCs)-derived exo-mi ...
DOI:
10.1016/j.ygeno.2022.110341

4. Cryptic erythrocytic infections in Plasmodium vivax, another challenge to its elimination

Author:
Carmen Fernandez-Becerra; Iris Aparici-Herraiz; Hernando A. del Portillo
Source:
Parasitology international 2022 v.87 pp. 102527
ISSN:
1383-5769
Subject:
Plasmodium vivax; antimalarials; bone marrow; exosomes; geographical distribution; humans; immune response; liver; malaria; parasitology; people; risk; spleen; Asia
Abstract:
... Human malaria caused by Plasmodium vivax infection (vivax malaria) is a major global health issue. It is the most geographically widespread form of the disease, accounting for 7 million annual clinical cases, the majority of cases in America and Asia and an estimation of over 2.5 billion people living under risk of infection. The general perception towards vivax malaria has shifted recently, follo ...
DOI:
10.1016/j.parint.2021.102527

5. Exosomal miR-9-5p derived from BMSCs alleviates apoptosis, inflammation and endoplasmic reticulum stress in spinal cord injury by regulating the HDAC5/FGF2 axis

Author:
Xin He; Jianan Zhang; Yunshan Guo; Xiaowei Yang; Yunfei Huang; Dingjun Hao
Source:
Molecular immunology 2022 v.145 pp. 97-108
ISSN:
0161-5890
Subject:
Western blotting; animal injuries; animal models; apoptosis; bone marrow; cytokines; data collection; endoplasmic reticulum stress; exosomes; fibroblast growth factor 2; histone deacetylase; histopathology; humans; inflammation; lipopolysaccharides; neurons; reporter genes; therapeutics; transmission electron microscopy
Abstract:
... Exosomes derived from human bone marrow mesenchymal stem cells (BMSCs) play potential protective roles in spinal cord injury (SCI). However, the underlying mechanisms remain not fully elucidated. Herein, we isolated exosomes from BMSCs, and exosome morphology and marker protein levels were identified by transmission electron microscopy (TEM) and Western blot, respectively. PC12 cells were treated ...
DOI:
10.1016/j.molimm.2022.03.007

6. Exosomes from bone marrow mesenchymal stem cells decrease chemosensitivity of acute myeloid leukemia cells via delivering miR-10a

Author:
Juan Wu; Yaqin Zhang; Xiaoyu Li; Jingyi Ren; Ling Chen; Jiadi Chen; Yingping Cao
Source:
Biochemical and biophysical research communications 2022 v.622 pp. 149-156
ISSN:
0006-291X
Subject:
bone marrow; coculture; exosomes; myeloid leukemia; research
Abstract:
... Bone marrow mesenchymal stem cells (BMSCs) are an integral part of the acute myeloid leukemia (AML) bone marrow microenvironment and contribute to AML progression. In this study, we explored the communication between BMSCs and AML cells via exosomes. The AML cells co-cultured with BMSCs-Exos were found to have lower chemosensitivity exposed to cytarabine, suggesting that BMSCs-Exos could protect A ...
DOI:
10.1016/j.bbrc.2022.07.017

7. Heme Oxygenase-1 targeting exosomes for temozolomide resistant glioblastoma synergistic therapy

Author:
Fawad Ur Rehman; Yang Liu; Qingshan Yang; Haoying Yang; Runhan Liu; Dongya Zhang; Pir Muhammad; Yanjie Liu; Sumaira Hanif; Muhammad Ismail; Meng Zheng; Bingyang Shi
Source:
Journal of controlled release 2022 v.345 pp. 696-708
ISSN:
0168-3659
Subject:
biomimetics; blood-brain barrier; bone marrow; brain; brain neoplasms; cytotoxicity; drug resistance; exosomes; glioblastoma; heme oxygenase (biliverdin-producing); nanocarriers; peptides
Abstract:
... Glioblastoma (GBM) is a highly fatal and recurrent brain cancer without a complete prevailing remedy. Although the synthetic nanotechnology-based approaches exhibit excellent therapeutic potential, the associated cytotoxic effects and organ clearance failure rest major obstacles from bench to clinics. Here, we explored allogeneic bone marrow mesenchymal stem cells isolated exosomes (BMSCEₓₒ) decor ...
DOI:
10.1016/j.jconrel.2022.03.036

8. LncRNA SNHG3 regulates the BMSC osteogenic differentiation in bone metastasis of breast cancer by modulating the miR-1273g-3p/BMP3 axis

Author:
Zijiu Sun; Jing Hu; Wei Ren; Yuting Fang; Kai Hu; Huomei Yu; Deyu Liao; Shiyan Liu; Lan Zhou; Tongchuan He; Yan Zhang
Source:
Biochemical and biophysical research communications 2022 v.594 pp. 117-123
ISSN:
0006-291X
Subject:
bone formation; bone marrow; breast neoplasms; exosomes; luciferase; metastasis; neoplasm cells; reporter genes; research
Abstract:
... Research on the role of lncRNAs in the process of bone metastasis in breast cancer (BM-BCa) has just begun at an early stage, and an increasing number of lncRNAs have been proved to play a regulatory role in the process of BM-BCa. Our study focused on the balance of osteogenic-osteoclast regulated by lncRNA-SNHG3 in bone metastasis microenvironment. SNHG3 level of clinical tissues and breast cance ...
DOI:
10.1016/j.bbrc.2021.12.075

9. Mesenchymal Stem Cell Mechanisms of Action and Clinical Effects in Osteoarthritis: A Narrative Review

Author:
Vilim Molnar; Eduard Pavelić; Kristijan Vrdoljak; Martin Čemerin; Emil Klarić; Vid Matišić; Roko Bjelica; Petar Brlek; Ivana Kovačić; Carlo Tremolada; Dragan Primorac
Source:
Genes 2022 v.13 no.6 pp. -
ISSN:
2073-4425
Subject:
adipose tissue; angiogenesis; apoptosis; autocrine signaling; biomedical research; bone marrow; disease progression; exosomes; fibrosis; mesenchymal stromal cells; mitosis; osteoarthritis; placenta
Abstract:
... With the insufficient satisfaction rates and high cost of operative treatment for osteoarthritis (OA), alternatives have been sought. Furthermore, the inability of current medications to arrest disease progression has led to rapidly growing clinical research relating to mesenchymal stem cells (MSCs). The availability and function of MSCs vary according to tissue source. The three primary sources i ...
DOI:
10.3390/genes13060949

10. MiR-145 enriched exosomes derived from bone marrow-derived mesenchymal stem cells protects against cerebral ischemia-reperfusion injury through downregulation of FOXO1

Author:
Hai Zhou; Jing Zhou; Hongwei Teng; Hua Yang; Jinsong Qiu; Xiangdong Li
Source:
Biochemical and biophysical research communications 2022 v.632 pp. 92-99
ISSN:
0006-291X
Subject:
animal models; apoptosis; bone marrow; brain; brain damage; cell communication; cell cycle checkpoints; exosomes; infarction; ischemia; microRNA; neuroglia; oxidative stress; phenotype; research; stroke
Abstract:
... Mesenchymal stem cells-derived exosomes (MSCs-Exo) were able to exert neuroprotective effects in brain injury after ischemic stroke (IS). In addition, exosomes containing microRNAs (miRNAs) can be transported to recipient cells to mediate intercellular communication. It has been shown that the level of miR-145 was significantly downregulated in brain tissues of rats subjected to middle cerebral ar ...
DOI:
10.1016/j.bbrc.2022.09.089

11. Neuroprotective effect of exosomes derived from bone marrow mesenchymal stem cells via activating TGR5 and suppressing apoptosis

Author:
Zhiqiang Liu; Xing Li; Zhongxing Ye; Hai Lin
Source:
Biochemical and biophysical research communications 2022 v.593 pp. 13-19
ISSN:
0006-291X
Subject:
apoptosis; bone marrow; cell cycle; exosomes; glucose; immunohistochemistry; infarction; mortality; neuroprotective effect; oxygen; rats; research; therapeutics
Abstract:
... Cerebral infarction has become one of the most common neurovascular diseases, and it leads to a high disability and death rate. The exosomes derived from bone marrow mesenchymal stem cells (BM-MSCs-exo) have been viewed as a potential therapeutic method for some diseases. However, the role of BM-MSCs-exo in cerebral infarction remains unclear. Middle cerebral artery occlusion (MCAO) rat and oxygen ...
DOI:
10.1016/j.bbrc.2022.01.039

12. Stem Cell Studies in Cardiovascular Biology and Medicine: A Possible Key Role of Macrophages

Author:
Nanako Kawaguchi; Toshio Nakanishi
Source:
Biology 2022 v.11 no.1 pp. -
ISSN:
2079-7737
Subject:
bone marrow; cardiomyocytes; chemokines; diagnostic techniques; exosomes; macrophages; medicine; microRNA; myocardial infarction; smooth muscle
Abstract:
... Stem cells are used in cardiovascular biology and biomedicine, and research in this field is expanding. Two types of stem cells have been used in research: induced pluripotent and somatic stem cells. Stem cell research in cardiovascular medicine has developed rapidly following the discovery of different types of stem cells. Induced pluripotent stem cells (iPSCs) possess potent differentiation abil ...
DOI:
10.3390/biology11010122

13. miR-223 in exosomes from bone marrow mesenchymal stem cells ameliorates rheumatoid arthritis via downregulation of NLRP3 expression in macrophages

Author:
Ying Huang; Daomin Lu; Wukai Ma; Jun Liu; Qiaoyi Ning; Fang Tang; Long Li
Source:
Molecular immunology 2022 v.143 pp. 68-76
ISSN:
0161-5890
Subject:
Western blotting; autoimmunity; bone marrow; computer software; exosomes; humans; immune response; immunogenicity; inflammasomes; interleukin-18; joints (animal); luciferase; macrophages; microRNA; necrosis; neoplasms; quantitative polymerase chain reaction; rheumatoid arthritis; synovitis; therapeutics
Abstract:
... Rheumatoid arthritis (RA) is an autoimmune disease with major clinical manifestations of human limb joint invasion, joint synovitis, and symmetrical lesions. In recent years, bone marrow mesenchymal stem cells (BMSCs) have been found to have low immunogenicity and immunomodulatory effects, which can regulate other types of cells through exosomes. However, the effect of BMSCs on immune response in ...
DOI:
10.1016/j.molimm.2022.01.002

14. microRNA-148a in Exosomes Derived from Bone Marrow Mesenchymal Stem Cells Alleviates Cardiomyocyte Apoptosis in Atrial Fibrillation by Inhibiting SMOC2

Author:
Weijuan Zhang; Yilong Man; Zhanghu Chen
Source:
Molecular biotechnology 2022 v.64 no.10 pp. 1076-1087
ISSN:
1073-6085
Subject:
Western blotting; apoptosis; atrial fibrillation; biomarkers; biotechnology; bone marrow; calcium-binding proteins; cardiomyocytes; caspase-3; cell viability; exosomes; flow cytometry; genes; microRNA; toxicity testing
Abstract:
... Exosomes-related microRNAs (miRNAs) have been considered to be the significant biomarkers contributing to the development of atrial fibrillation (AF). We observed the implicit mechanism of exosomes-miR-148a derived from bone marrow mesenchymal stem cells (BMSCs) in AF. The AF cell and mice models were established firstly. QRT-PCR and Western blot analysis were applied to detect the expression of m ...
DOI:
10.1007/s12033-022-00487-z

15. Analysis of Peripheral Blood Mononuclear Cells Gene Expression Highlights the Role of Extracellular Vesicles in the Immune Response following Hematopoietic Stem Cell Transplantation in Children

Author:
Wojciech Strojny; Kinga Kwiecińska; Przemysław Hałubiec; Wojciech Kowalczyk; Karol Miklusiak; Agnieszka Łazarczyk; Szymon Skoczeń
Source:
Genes 2021 v.12 no.12 pp. -
ISSN:
2073-4425
Subject:
B-lymphocytes; bioinformatics; bone marrow; cell transplantation; epigenetics; exosomes; gene expression; gene expression regulation; gene ontology; genes; hematopoietic stem cells; immune response; microarray technology; prospective studies; protein-protein interactions; risk
Abstract:
... Hematopoietic stem cell transplantation (HSCT) is an effective treatment method used in many neoplastic and non-neoplastic diseases that affect the bone marrow, blood cells, and immune system. The procedure is associated with a risk of adverse events, mostly related to the immune response after transplantation. The aim of our research was to identify genes, processes and cellular entities involved ...
DOI:
10.3390/genes12122008

16. Bone marrow mesenchymal stem cell-derived exosomes alleviate hyperoxia-induced lung injury via the manipulation of microRNA-425

Author:
Yunfei Wu; Jun Li; Rui Yuan; Zihui Deng; Xu Wu
Source:
Archives of biochemistry and biophysics 2021 v.697 pp. 108712
ISSN:
0003-9861
Subject:
apoptosis; biophysics; bone marrow; cell viability; exosomes; hyperoxia; luciferase; lungs; microRNA; protective effect; rats
Abstract:
... Hyperoxia-induced lung injury (HILI) is an acute lung injury (LI) induced by extended periods of exposure to hyperoxia. Alleviating LI by bone marrow mesenchymal stem cell-derived exosomes (BMSCs-Exos) and microRNAs (miRs) has been previously reported. This study is devised to probe the interaction between BMSCs-Exos and miR-425 in HILI.Firstly, BMSCs-Exos were isolated and identified. Then, HILI ...
DOI:
10.1016/j.abb.2020.108712

17. Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-1-5p reduces proliferation and raises apoptosis of bladder cancer cells via targeting ABL2

Author:
Dewang Fu; Ben Liu; Huamao Jiang; Zhaowei Li; Chenghui Fan; Li'e Zang
Source:
Genomics 2021 v.113 no.3 pp. 1338-1348
ISSN:
0888-7543
Subject:
apoptosis; bone marrow; cell communication; coculture; exosomes; genomics; microRNA; tyrosine; urinary bladder neoplasms
Abstract:
... Exosomes are involved in intercellular communication via specialized molecular cargo, such as microRNAs (miRNAs). However, the mechanisms underlying exosomal miR-19b-1-5p in bladder cancer remain largely unknown, thus, we aim to investigate the effect of exosomal miR-19b-1-5p on bladder cancer with the involvement of non-receptor protein tyrosine kinase Arg (ABL2). miR-19b-1-5p and ABL2 expression ...
DOI:
10.1016/j.ygeno.2021.03.011

18. Bone marrow mesenchymal stem cells-derived exosomal microRNA-19b-3p targets SOCS1 to facilitate progression of esophageal cancer

Author:
Yanchao Deng; Ainiwaer Julaiti; Wei Ran; Yao He
Source:
Life sciences 2021 v.278 pp. 119491
ISSN:
0024-3205
Subject:
apoptosis; bone marrow; cytokines; esophageal neoplasms; exosomes; luciferase; microRNA; reporter genes
Abstract:
... Exosomes can convey particular microRNAs (miRNAs) to affect biological functions of cancer cells. Nevertheless, the impact of bone marrow mesenchymal stem cells (BMSCs)-derived exosomes (BMSC-exos) transmitting miR-19b-3p on esophageal cancer (EC) progression remains scarcely studied. We aimed to explore the role of BMSC-exos mediating miR-19b-3p in EC cell growth. Eighty-three cases of EC patient ...
DOI:
10.1016/j.lfs.2021.119491

19. Contribution of extracellular vesicles in normal hematopoiesis and hematological malignancies

Author:
Soudeh Ghafouri-Fard; Vahid Niazi; Mohammad Taheri
Source:
Heliyon 2021 v.7 no.1 pp. e06030
ISSN:
2405-8440
Subject:
bone marrow; endosomes; exosomes; hematopoiesis; leukemia; lipids; medicine; megakaryocytes; myeloma; pathogenesis; plasma membrane; therapeutics
Abstract:
... Extracellular vesicles (EVs) are lipid bilayer-enclosed microparticles that have prominent roles in the intercellular crosstalk. EVs are secreted after fusion of endosomes with the plasma membrane (exosomes) or shed from the plasma membrane (microvesicles). These microparticles modulate bone marrow microenvironment and alter differentiation and expansion of normal hematopoietic cells. EVs originat ...
DOI:
10.1016/j.heliyon.2021.e06030

20. Early-senescent bone marrow mesenchymal stem cells promote C2C12 cell myogenic differentiation by preventing the nuclear translocation of FOXO3

Author:
Ji Che; Cuidi Xu; Yuanyuan Wu; Peiyu Jia; Qi Han; Yantao Ma; Xiaolei Wang; Yijie Du; Yongjun Zheng
Source:
Life sciences 2021 v.277 pp. 119520
ISSN:
0024-3205
Subject:
bone marrow; exosomes; fluorescent antibody technique; gene expression; mice; muscle development; muscles; myoblasts; myogenin; myosin heavy chains
Abstract:
... Mouse bone marrow mesenchymal stem cells (BMSCs) are pluripotent cells with self-renewal and differentiation abilities. Since the effects of senescent BMSCs on C2C12 cells are not fully clear, the present study aimed to elucidate these effects. Senescence-associated β-galactosidase staining and western blotting were performed to confirm the senescence of BMSCs. Immunofluorescence and western blott ...
DOI:
10.1016/j.lfs.2021.119520