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1. A rapid capillary-channeled polymer (C-CP) fiber spin-down tip approach for the isolation of plant-derived extracellular vesicles (PDEVs) from 20 common fruit and vegetable sources

Author:
Kaylan K. Jackson; Carolina Mata; R. Kenneth Marcus
Source:
Talanta 2023 v.252 pp. 123779
ISSN:
0039-9140
Subject:
absorbance; biochemical compounds; cell communication; enzyme-linked immunosorbent assay; exosomes; fruits; humans; hydrophobic interaction chromatography; isolation techniques; polymers; solid phase extraction; therapeutics; transmission electron microscopy; vegetables
Abstract:
... In the emerging field of phyto-nanotechnology, 30–200 nm plant-derived extracellular vesicles (PDEVs) are now known to contain active biomolecules that mediate cell-to-cell communication processes in a manner very similar to exosomes in mammalian cells. The ability to deliver cargo across cellular membranes suggests that botanical systems could be used in the mass production of therapeutic vectors ...
DOI:
10.1016/j.talanta.2022.123779

2. ASIC1a promotes hepatic stellate cell activation through the exosomal miR-301a-3p/BTG1 pathway

Author:
Shao-hua Luan; Yu-qing Yang; Man-ping Ye; Hui Liu; Qiu-fan Rao; Jin-ling Kong; Fan-rong Wu
Source:
International journal of biological macromolecules 2022 v.211 pp. 128-139
ISSN:
0141-8130
Subject:
B-lymphocytes; exosomes; genes; information exchange; ion channels; liver cirrhosis; microRNA; transcriptome
Abstract:
... Activation of hepatic stellate cells (HSCs) is a key cause of liver fibrosis. However, the mechanisms leading to the activation of HSCs are not fully understood. In the pathological process, acid-sensing ion channel 1a (ASIC1a) is widely involved in the development of inflammatory diseases, suggesting that ASIC1a may play an important role in liver fibrosis. We found that in an acidic environment, ...
DOI:
10.1016/j.ijbiomac.2022.05.041

3. Acetylation of Sesquiterpenyl Epoxy-Cyclohexenoids Regulates Fungal Growth, Stress Resistance, Endocytosis, and Pathogenicity of Nematode-Trapping Fungus Arthrobotrys oligospora via Metabolism and Transcription

Author:
Yong-Hong Chen; Long-Long Zhang; Li-Jun Wang; Xu-Tong Yue; Qun-Fu Wu; Yang Jiang; Ke-Qin Zhang; Xue-Mei Niu
Source:
Journal of agricultural and food chemistry 2022 v.70 no.20 pp. 6145-6155
ISSN:
1520-5118
Subject:
Arthrobotrys oligospora; DNA; acetylation; autophagosomes; biosynthesis; endocytosis; exosomes; food chemistry; fungal growth; glutamine; mutants; nematophagous fungi; pathogenicity; phenylpropanoids; polyketides; soil; stress tolerance; transcription (genetics); viruses
Abstract:
... Sesquiterpenyl epoxy-cyclohexenoids (SECs) that depend on a polyketide synthase–terpenoid synthase (PKS–TPS) pathway are widely distributed in plant pathogenic fungi. However, the biosynthesis and function of the acetylated SECs still remained cryptic. Here, we identified that AOL_s00215g 273 (273) was responsible for the acetylation of SECs in Arthrobotrys oligospora via the construction of Δ273, ...
DOI:
10.1021/acs.jafc.2c01914

4. Adipocytes‐Derived Exosomal microRNA‐1224 Inhibits M2 Macrophage Polarization in Obesity‐Induced Adipose Tissue Inflammation via MSI2‐Mediated Wnt/β‐Catenin Axis

Author:
Dongdong Zhang; Xiaoyan Yao; Yaqin Teng; Tiantian Zhao; Liangyan Lin; Yuanyuan Li; Hongxia Shang; Yongjun Jin; Qingsong Jin
Source:
Molecular nutrition & food research 2022 v.66 no.18 pp. e2100889
ISSN:
1613-4125
Subject:
RNA; adipocytes; coculture; epididymis; exosomes; flow cytometry; food research; high fat diet; immunohistochemistry; inflammation; macrophages; phenotype; white adipose tissue
Abstract:
... SCOPE: Phenotypic switch of macrophage polarization in adipose tissue has been associated with obesity‐induced adipose tissue inflammation (OATI). Therefore, this study aims to explore the possible mechanism of adipocytes‐derived exosomes (ADEs) carrying microRNA‐1224 (miR‐1224) in M2 macrophage polarization of OATI. METHODS AND RESULTS: miR‐1224‐knockout (miR‐1224‐KO) mice for this study, and iso ...
DOI:
10.1002/mnfr.202100889

5. Adipose mesenchymal stem cell–derived exosomal microRNAs ameliorate polycystic ovary syndrome by protecting against metabolic disturbances

Author:
Maosheng Cao; Yun Zhao; Tong Chen; Zijiao Zhao; Boqi Zhang; Chenfeng Yuan; Xin Wang; Lu Chen; Nan Wang; Chunjin Li; Xu Zhou
Source:
Biomaterials 2022 v.288 pp. 121739
ISSN:
0142-9612
Subject:
B-lymphocytes; animal models; biocompatible materials; cytokines; exosomes; genes; immunity; liver; metabolic diseases; metabolism; microRNA; non-coding RNA; phenotype; polycystic ovary syndrome; rats; reproduction
Abstract:
... Polycystic ovary syndrome (PCOS) is the most common endocrine and metabolic disorder in women of childbearing age. Adipose mesenchymal stem cells (AMSCs) secrete cytokines involved in the regulation of metabolism and immunity. However, it remains unclear whether exosomes secreted by AMSCs (AMSC-EXOs) can rescue the polycystic phenotype and metabolic dysfunction in PCOS ovaries. Here, we show that ...
DOI:
10.1016/j.biomaterials.2022.121739

6. Administration of circRNA_0075932 shRNA exhibits a therapeutic effect on burn-associated infection in obese rats

Author:
Haidong Wu; Sheng He; Wei Zhang; Ying Huang; Qiang Zhang; Dan Liu
Source:
Biochemical and biophysical research communications 2022 v.608 pp. 82-89
ISSN:
0006-291X
Subject:
adipose tissue; exosomes; heat stress; hospitals; inflammation; luciferase; obesity; quantitative polymerase chain reaction; rats; research; therapeutics; transcription factor NF-kappa B
Abstract:
... miR-495 and miR-142–3p suppress inflammatory response. Circ_0075932 is overexpressed in the burned skin of obese individuals and is involved in the regulation of PUM2 and AuroraA kinase, thus activating the NF-kB pathway. Obesity significantly influences the length of hospital stay for paediatric burn patients, who present symptoms of slower healing or greater functional impairment. In this study, ...
DOI:
10.1016/j.bbrc.2022.03.145

7. Advanced approaches for improving bioavailability and controlled release of anthocyanins

Author:
Yixiao Shen; Ning Zhang; Jinlong Tian; Guang Xin; Ling Liu; Xiyun Sun; Bin Li
Source:
Journal of controlled release 2022 v.341 pp. 285-299
ISSN:
0168-3659
Subject:
anthocyanins; bioavailability; color; exosomes; humans; intestinal absorption; polysaccharides; protective effect; risk; solubility
Abstract:
... Anthocyanins are a group of phytochemicals responsible for the purple or red color of plants. Additionally, they are recognized to have health promoting functions including anti-cardiovascular, anti-thrombotic, anti-diabetic, antimicrobial, neuroprotective, and visual protective effect as well as anti-cancer activities. Thus, consumption of anthocyanin supplement or anthocyanin-rich foods has been ...
DOI:
10.1016/j.jconrel.2021.11.031

8. Advanced on-site and in vitro signal amplification biosensors for biomolecule analysis

Author:
Yuning Wang; Bin Li; Tongtong Tian; Yujie Liu; Juxiang Zhang; Kun Qian
Source:
Trends in analytical chemistry 2022 v.149 pp. 116565
ISSN:
0165-9936
Subject:
analytical chemistry; biomarkers; biosensors; early diagnosis; electrochemistry; exosomes; fluorescence; mass spectrometry; metabolites; neoplasms
Abstract:
... Point-of-care testing (POCT), as one part of in vitro diagnostic (IVD), has been gradually used in early diagnosis and personalized treatment in the clinics. Accurate and sensitive detection of clinically related biomarkers is valuable, especially using the methods with simple, rapid, high throughput, miniaturization, and low cost. Nowadays, various biomolecules have been regarded as biomarkers fo ...
DOI:
10.1016/j.trac.2022.116565

9. Affinity-based isolation of extracellular vesicles by means of single-domain antibodies bound to macroporous methacrylate-based copolymer

Author:
Lidija Filipović; Milica Spasojević; Radivoje Prodanović; Aleksandra Korać; Suzana Matijaševic; Goran Brajušković; Ario de Marco; Milica Popović
Source:
New biotechnology 2022 v.69 pp. 36-48
ISSN:
1871-6784
Subject:
biomarkers; biotechnology; cell culture; chromatography; composite polymers; culture media; exosomes; fractionation; humans; lipoproteins; porous media
Abstract:
... Correct elucidation of physiological and pathological processes mediated by extracellular vesicles (EV) is highly dependent on the reliability of the method used for their purification. Currently available chemical/physical protocols for sample fractionation are time-consuming, often scarcely reproducible and their yields are low. Immuno-capture based approaches could represent an effective purifi ...
DOI:
10.1016/j.nbt.2022.03.001

10. All-in-One Strategy for Downstream Molecular Profiling of Tumor-Derived Exosomes

Author:
Shurong Wang; Ying He; Jiayin Lu; Yuqing Wang; Xiaofeng Wu; Guoquan Yan; Xiaoni Fang; Baohong Liu
Source:
ACS applied materials & interfaces 2022 v.14 no.32 pp. 36341-36352
ISSN:
1944-8252
Subject:
biomarkers; cell culture; cost effectiveness; culture media; exosomes; hydrophilicity; nanopores; proteolysis; proteomics; stomach neoplasms
Abstract:
... In light of the significance of exosomes in cancer diagnosis and treatment, it is important to understand the components and functions of exosomes. Herein, an all-in-one strategy has been proposed for comprehensive characterization of exosomal proteins based on nanoporous TiO₂ clusters acting as both an extractor for exosome isolation and a nanoreactor for downstream molecular profiling. With the ...
DOI:
10.1021/acsami.2c07143

11. Analysis of Keratinocytic Exosomes from Diabetic and Nondiabetic Mice by Charge Detection Mass Spectrometry

Author:
Brooke A. Brown; Poornachander R. Guda; Xuyao Zeng; Adam Anthony; Andrew Couse; Lauren F. Barnes; Edie M. Sharon; Jonathan C. Trinidad; Chandan K. Sen; Martin F. Jarrold; Subhadip Ghatak; David E. Clemmer
Source:
Analytical chemistry 2022 v.94 no.25 pp. 8909-8918
ISSN:
1520-6882
Subject:
RNA; analytical chemistry; electron microscopy; exosomes; fluorescent antibody technique; genome; heterozygosity; inflammation; mass spectrometry; mice; proteomics
Abstract:
... Unresolved inflammation compromises diabetic wound healing. Recently, we reported that inadequate RNA packaging in murine wound-edge keratinocyte-originated exosomes (Exoκ) leads to persistent inflammation [Zhou, X.ACS Nano2020, 14(10), 12732−12748]. Herein, we use charge detection mass spectrometry (CDMS) to analyze intact Exoκ isolated from a 5 day old wound-edge tissue of diabetic mice and a he ...
DOI:
10.1021/acs.analchem.2c00453

12. Anti-infection roles of miR-155-5p packaged in exosomes secreted by dendritic cells infected with Toxoplasma gondii

Author:
Dan Jiang; Shuizhen Wu; Liqing Xu; Guantai Xie; Dongliang Li; Hongjuan Peng
Source:
Parasites & vectors 2022 v.15 no.1 pp. 3
ISSN:
1756-3305
Subject:
Protozoa; Toxoplasma gondii; Western blotting; cell communication; exosomes; genes; interleukin-6; macrophages; mice; pregnancy; secretion; tachyzoites; toxoplasmosis; transmission electron microscopy; ultracentrifugation
Abstract:
... BACKGROUND: Toxoplasma gondii is a zoonotic intracellular protozoon that is estimated to infect about 30% of the world’s population, resulting in toxoplasmosis in immunocompromised patients and adverse outcomes in cases of primary infection during pregnancy. Exosomes are tubular vesicles secreted by cells, and function in intercellular communication. It has been reported that the exosomes secreted ...
DOI:
10.1186/s13071-021-05003-x

13. Antiadhesive nanosome elicits role of glycocalyx of tumor cell-derived exosomes in the organotropic cancer metastasis

Author:
Ryosuke Koide; Nozomi Hirane; Daiki Kambe; Yasuhiro Yokoi; Michiru Otaki; Shin-Ichiro Nishimura
Source:
Biomaterials 2022 v.280 pp. 121314
ISSN:
0142-9612
Subject:
biocompatible materials; biogenesis; exosomes; fluorescence; glycosylation; metastasis; models; neoplasm cells; neoplasms
Abstract:
... Despite emerging importance of tumor cells-derived exosomes in cancer metastasis, the heterogeneity of exosome populations has largely hampered systemic characterization of their molecular composition, biogenesis, and functions. This study communicates a novel method for predicting and targeting pre-metastatic sites based on an exosome model “fluorescent cancer glyconanosomes” displaying N-glycans ...
DOI:
10.1016/j.biomaterials.2021.121314

14. Apoptotic bodies for advanced drug delivery and therapy

Author:
Min Zhou; Yong-Jiang Li; Yu-Cheng Tang; Xin-Yan Hao; Wen-Jie Xu; Da-Xiong Xiang; Jun-Yong Wu
Source:
Journal of controlled release 2022 v.351 pp. 394-406
ISSN:
0168-3659
Subject:
apoptosis; biochemical compounds; biocompatibility; disease diagnosis; drugs; exosomes; immunotherapy
Abstract:
... Extracellular vesicles (EVs) have emerged as promising candidates for multiple biomedical applications. Major types of EVs include exosomes, microvesicles, and apoptotic bodies (ABs). ABs are conferred most properties from parent cells in the final stages of apoptosis. A wide variety of sources and stable morphological features are endowed to ABs by the rigorous apoptotic program. ABs accommodate ...
DOI:
10.1016/j.jconrel.2022.09.045

15. Application and prospect of exosomes combined with Chinese herbal medicine in orthopedics

Author:
Qianxin Liang; Chaoxin Jiang; Qing Zhao; Zhaodi Guo; Manlin Xie; Yanfang Zou; Xiuping Cai; Jing Su; Zhiliang He; Kewei Zhao
Source:
Journal of herbal medicine 2022 v.35 pp. 100589
ISSN:
2210-8033
Subject:
angiogenesis; cell communication; exosomes; herbal medicines; immunity; modernization; orthopedics
Abstract:
... Exosomes are vesicle-like bodies of that are actively secreted by cells to the extracellular surrounding with a diameter of 40–100 nm. They have several physiological functions, such as cell-cell communication, antitumor immunity, and angiogenesis promotion. Exosomes have many important roles and are extensively distributed in various fluids throughout the body, and therefore, they are of signific ...
DOI:
10.1016/j.hermed.2022.100589

16. Aptamer-Initiated Catalytic Hairpin Assembly Fluorescence Assay for Universal, Sensitive Exosome Detection

Author:
Jiaqi Zhou; Qiuyuan Lin; Zhipeng Huang; Huiwen Xiong; Bin Yang; Hui Chen; Jilie Kong
Source:
Analytical chemistry 2022 v.94 no.15 pp. 5723-5728
ISSN:
1520-6882
Subject:
analytical chemistry; biomarkers; blood serum; calibration; cell communication; detection limit; exosomes; fluorescence
Abstract:
... Cancer-cell-derived exosomes are regarded as noninvasive biomarkers for early cancer diagnosis because of their critical roles in intercellular communication and molecular exchange. A robust aptamer-initiated catalytic hairpin assembly (AICHA) fluorescence assay is proposed for universal, sensitive detection of cancer-derived exosomes. The AICHA was verified with the specific detection of MCF-7 ce ...
DOI:
10.1021/acs.analchem.2c00231

17. Assessment of microRNA profiles in small extracellular vesicles isolated from bovine colostrum with different immunoglobulin G concentrations

Author:
T. Ma; W. Li; Y. Chen; E.R. Cobo; C. Windeyer; L. Gamsjäger; Q. Diao; Y. Tu; L.L. Guan
Source:
JDS communications 2022 pp. -
ISSN:
2666-9102
Subject:
axons; bioinformatics; cow colostrum; exosomes; focal adhesions; immunoglobulin G; microRNA; neonates; passive immunity; standard deviation; urine
Abstract:
... The consumption of bovine colostrum by newborn calves during the first days of life is essential to ensure the transfer of passive immunity. In addition to critical IgG, colostrum also contains non-IgG biomolecules, including microRNA (miRNA). The present study investigated the profiles of miRNA in small extracellular vesicles (sEV) isolated from bovine colostrum with high (256.5 ± 5.7 mg/mL, mean ...
DOI:
10.3168/jdsc.2022-0225

18. Astrocytes promote the proliferation of oligodendrocyte precursor cells through connexin 47-mediated LAMB2 secretion in exosomes

Author:
Nannan Cheng; Yuanfeng Xiong; Wenjin Zhang; Xiaohong Wu; Zhongxiang Sun; Lei Zhang; Hong Wu; Yong Tang; Yan Peng
Source:
Molecular biology reports 2022 v.49 no.8 pp. 7263-7273
ISSN:
0301-4851
Subject:
DNA replication; Western blotting; astrocytes; brain; coculture; connexins; cyclins; exosomes; gene ontology; interphase; mass spectrometry; molecular biology; oligodendroglia; secretion; transcriptome; transmission electron microscopy
Abstract:
... BACKGROUND: Oligodendrocyte precursor cells (OPCs) can proliferate and differentiate into oligodendrocytes, the only myelin-forming cells in the central nervous system. Proliferating OPCs promotes remyelination in neurodegenerative diseases. Astrocytes (ASTs) are the most widespread cells in the brain and play a beneficial role in the proliferation of OPCs. Connexin 47 (Cx47) is the main component ...
DOI:
10.1007/s11033-022-07508-9

19. Autophagy induced by Schwann cell-derived exosomes promotes recovery after spinal cord injury in rats

Author:
Dayu Pan; Shibo Zhu; Weixin Zhang; Zhijian Wei; Fuhan Yang; Zhenglong Guo; Guangzhi Ning; Shiqing Feng
Source:
Biotechnology letters 2022 v.44 no.1 pp. 129-142
ISSN:
0141-5492
Subject:
acetylation; animal injuries; apoptosis; autophagy; biotechnology; exosomes; microtubules; polymerization
Abstract:
... Spinal cord injury (SCI) is catastrophic to humans and society. However, there is currently no effective treatment for SCI. Autophagy is known to serve critical roles in both the physiological and pathological processes of the body, but its facilitatory and/or deleterious effects in SCI are yet to be completely elucidated. This study aimed to use primary Schwann cell-derived exosomes (SCDEs) to tr ...
DOI:
10.1007/s10529-021-03198-8

20. BMAL1 induces colorectal cancer metastasis by stimulating exosome secretion

Author:
Pengjuan Dong; Yaping Wang; Yutong Liu; Chunting Zhu; Jiaxin Lin; Ruizhe Qian; Luchun Hua; Chao Lu
Source:
Molecular biology reports 2022 v.49 no.1 pp. 373-384
ISSN:
0301-4851
Subject:
Western blotting; centrifugation; circadian clocks; circadian rhythm; colorectal neoplasms; exosomes; humans; luciferase; metastasis; molecular biology; secretion; transcription (genetics); transmission electron microscopy
Abstract:
... BACKGROUND: To adapt to daily changes in the external environment, organisms have developed circadian rhythm systems with a period of approximately 24 h. Many studies have reported that both circadian rhythms and exosomes play important roles in the development and metastasis of tumors. However, whether circadian clock genes can affect the progression of tumors by regulating exosomes remains uncle ...
DOI:
10.1007/s11033-021-06883-z